TY - JOUR AU - Jia, Shanshan AU - Zhang, Qiang AU - Wang, Yu AU - Wei, Xiaowei AU - Gu, Hui AU - Liu, Dan AU - Ma, Wei AU - He, Yiwen AU - Luo, Wenting AU - Yuan, Zhengwei TI - Identification by RNA-Seq of let-7 clusters as prenatal biomarkers for nonsyndromic cleft lip with palate JF - ANNALS OF THE NEW YORK ACADEMY OF SCIENCES J2 - ANN NY ACAD SCI VL - 1516 PY - 2022 IS - 1 SP - 234 EP - 246 PG - 13 SN - 0077-8923 DO - 10.1111/nyas.14868 UR - https://m2.mtmt.hu/api/publication/33034103 ID - 33034103 LA - Chinese DB - MTMT ER - TY - JOUR AU - Reza Karimzadeh, Mohammad AU - Ehtesham, Naeim AU - Mortazavi, Deniz AU - Azhdari, Sara AU - Mosallaei, Meysam AU - Nezamnia, Maria TI - Alterations of epigenetic landscape in Down syndrome carrying pregnancies: a systematic review of case-control studies JF - EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY J2 - EUR J OBSTET GYN R B (EJOG) VL - 264 PY - 2021 SP - 189 EP - 199 PG - 11 SN - 0301-2115 DO - 10.1016/j.ejogrb.2021.06.027 UR - https://m2.mtmt.hu/api/publication/32098164 ID - 32098164 LA - English DB - MTMT ER - TY - JOUR AU - Biró, Orsolya AU - Rigó, János AU - Nagy, Bálint TI - Noninvasive prenatal testing for congenital heart disease - cell-free nucleic acid and protein biomarkers in maternal blood. JF - JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE J2 - J MATERN-FETAL NEO M VL - 33 PY - 2020 IS - 6 SP - 1044 EP - 1050 PG - 8 SN - 1476-7058 DO - 10.1080/14767058.2018.1508437 UR - https://m2.mtmt.hu/api/publication/3421053 ID - 3421053 AB - CONTEXT: Congenital heart disease (CHD) is the most common fetal malformation. Prenatal ultrasonography is routinely applied for the screening of CHD but many factors influence its diagnostic accuracy. The introduction of new biomarkers could facilitate the identification of high-risk pregnancies. OBJECTIVE: In our review, our aim was to collect expression studies of cell-free nucleic acids and proteins in maternal circulation. Syndromic CHDs which can be detected by noninvasive prenatal testing (NIPT) techniques were also discussed. METHODS: PubMed and Web of Science databases were screened for studies where the levels of potential CHD biomarkers were measured in maternal blood samples. Available NIPT tests were collected from the providers' resources. RESULTS: There are nine CHD-associated chromosomal abnormalities, five aneuploidies, and four microdeletions, which are included in NIPT panels. We found eight articles from which five included the analysis of specific cell-free RNA expression and three measurements of protein levels. CONCLUSION: Most of the common heart-related chromosomal aberrations can be diagnosed by NIPT. Specific cell-free RNAs and circulating proteins seem to be potential biomarkers for fetal CHDs. The application of these new biomarkers could improve the detection rate at early pregnancy, making it possible to provide optimal perinatal and perioperative management. LA - English DB - MTMT ER - TY - JOUR AU - Huang, Tianchu AU - Gu, Hui AU - Yuan, Zhengwei TI - 胎儿先天性心脏病无创性产前筛查分子 标志物的研究进展 JF - Journal of Developmental Medicine J2 - J Dev Med VL - 8 PY - 2020 IS - 3 SP - 267 EP - 271 PG - 5 SN - 2095-5340 DO - 10.3969/j.issn.2095-5340.2020.03.014 UR - https://m2.mtmt.hu/api/publication/33059695 ID - 33059695 LA - Chinese DB - MTMT ER - TY - JOUR AU - Ma, Lifei AU - Zhou, Huixia AU - Zhou, Xiaoguang AU - Cao, Hualin AU - Liu, Dehong AU - Tao, Tian TI - Clinical study of laparoscopic Lich-Gregoir technique for the treatment of primary vesicoureteral reflux in children JF - Journal of Developmental Medicine J2 - J Dev Med VL - 8 PY - 2020 IS - 3 SP - 262 EP - 271 PG - 10 SN - 2095-5340 DO - 10.3969/j.issn.2095-5340.2020.03.013 UR - https://m2.mtmt.hu/api/publication/33059706 ID - 33059706 LA - Chinese DB - MTMT ER - TY - JOUR AU - Rahat, Beenish AU - Ali, Taqveema AU - Sapehia, Divika AU - Mahajan, Aatish AU - Kaur, Jyotdeep TI - Circulating Cell-Free Nucleic Acids as Epigenetic Biomarkers in Precision Medicine JF - FRONTIERS IN GENETICS J2 - FRONT GENET VL - 11 PY - 2020 PG - 20 SN - 1664-8021 DO - 10.3389/fgene.2020.00844 UR - https://m2.mtmt.hu/api/publication/31710184 ID - 31710184 AB - The circulating cell-free nucleic acids (ccfNAs) are a mixture of single- or double-stranded nucleic acids, released into the blood plasma/serum by different tissues via apoptosis, necrosis, and secretions. Under healthy conditions, ccfNAs originate from the hematopoietic system, whereas under various clinical scenarios, the concomitant tissues release ccfNAs into the bloodstream. These ccfNAs include DNA, RNA, microRNA (miRNA), long non-coding RNA (lncRNA), fetal DNA/RNA, and mitochondrial DNA/RNA, and act as potential biomarkers in various clinical conditions. These are associated with different epigenetic modifications, which show disease-related variations and so finding their role as epigenetic biomarkers in clinical settings. This field has recently emerged as the latest advance in precision medicine because of its clinical relevance in diagnostic, prognostic, and predictive values. DNA methylation detected in ccfDNA has been widely used in personalized clinical diagnosis; furthermore, there is also the emerging role of ccfRNAs like miRNA and lncRNA as epigenetic biomarkers. This review focuses on the novel approaches for exploring ccfNAs as epigenetic biomarkers in personalized clinical diagnosis and prognosis, their potential as therapeutic targets and disease progression monitors, and reveals the tremendous potential that epigenetic biomarkers present to improve precision medicine. We explore the latest techniques for both quantitative and qualitative detection of epigenetic modifications in ccfNAs. The data on epigenetic modifications on ccfNAs are complex and often milieu-specific posing challenges for its understanding. Artificial intelligence and deep networks are the novel approaches for decoding complex data and providing insight into the decision-making in precision medicine. LA - English DB - MTMT ER - TY - JOUR AU - Videira, Raquel Figuinha AU - da Costa Martins, Paula A. AU - Falcão-Pires, Inês TI - Non-Coding RNAs as Blood-Based Biomarkers in Cardiovascular Disease JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 21 PY - 2020 IS - 23 SN - 1661-6596 DO - 10.3390/ijms21239285 UR - https://m2.mtmt.hu/api/publication/31782877 ID - 31782877 LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Bálint TI - Cell-free nucleic acids in prenatal diagnosis and pregnancy-associated diseases JF - ELECTRONIC JOURNAL OF THE INTERNATIONAL FEDERATION OF CLINICAL CHEMISTRY AND LABORATORY MEDICINE J2 - E JIFCC VL - 30 PY - 2019 IS - 2 SP - 215 EP - 223 PG - 9 SN - 1650-3414 UR - https://m2.mtmt.hu/api/publication/30758075 ID - 30758075 N1 - Export Date: 3 August 2019 Correspondence Address: Nagy, B.; Department of Human Genetics, Faculty of Medicine, University of Debrecen, Egyetem tér 1, Hungary; email: nagy.balint@med.unideb.hu AB - There is a great effort to find out the biological role of cell-free nucleic acids (cfNAs). They are considered very promising targets in the diagnosis of genetic diseases. Non-invasive sampling (liquid biopsy) has recently become a very popular method, and new molecular biological techniques have been developed for these types of samples. Application of next-generation sequencing (NGS) and massively parallel sequencing (MPS) is spreading fast. These are the part of the arsenal of the modern prenatal genetic diagnostic laboratories by now. Cell-free DNA based noninvasive prenatal testing accounts for more than half of the prenatal genetic tests performed, it is gradually replacing the invasive amniocentesis or chorionic villus sample-based diagnostics. Besides that, new non-coding RNAs are taking more attention: microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) are in the focus of the clinical research to detect the most common pregnancy-associated diseases, like preeclampsia, fetal growth restriction, congenital heart diseases and gestational diabetes. The research is at advanced stage on the use of microRNAs, while lncRNAs and circRNAs are still promising targets. In this review, comprehensive information is given about the recent developments on this field. LA - English DB - MTMT ER - TY - CHAP AU - Simeoni, Umberto AU - Saliba, Elie TI - The fetus and the neonate: Immediate, short-, and long-term impact T2 - New Technologies and Perinatal Medicine: Prediction and Prevention of Pregnancy Complications PB - CRC Press CY - Boca Raton, Florida SN - 9781315201955 T3 - New Technol. and Perinat. Med.: Predict. and Prev. of Pregnancy Complicat. PY - 2019 SP - 56 EP - 59 PG - 4 UR - https://m2.mtmt.hu/api/publication/33034100 ID - 33034100 LA - English DB - MTMT ER - TY - JOUR AU - Vizitiu, A.-C. AU - Stambouli, D. AU - Pavel, A.-G. AU - Muresan, M.-C. AU - Anastasiu, D.M. AU - Bejinar, C. AU - Alexa, A. AU - Marian, C. AU - Sirbu, I.O. AU - Sima, L. TI - Mature miR-99a upregulation in the amniotic fluid samples from female fetus down syndrome pregnancies: A pilot study JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 55 PY - 2019 IS - 11 SN - 1010-660X DO - 10.3390/medicina55110728 UR - https://m2.mtmt.hu/api/publication/31356837 ID - 31356837 N1 - Export Date: 22 June 2020 LA - English DB - MTMT ER - TY - JOUR AU - Chen, Lizhu AU - Guan, Johnny AU - Wei, Qiuju AU - Yuan, Zhengwei AU - Zhang, Mo TI - Potential role of "omics" technique in prenatal diagnosis of congenital heart defects JF - CLINICA CHIMICA ACTA J2 - CLIN CHIM ACTA VL - 482 PY - 2018 SP - 185 EP - 190 PG - 6 SN - 0009-8981 DO - 10.1016/j.cca.2018.04.011 UR - https://m2.mtmt.hu/api/publication/27592695 ID - 27592695 N1 - Export Date: 22 June 2020 CODEN: CCATA LA - English DB - MTMT ER - TY - JOUR AU - Hu, Yue AU - Xu, Yuanyuan AU - Hao, Yan AU - Meng, Xianfang TI - 21q21.1-21.3 micrornas JF - Acta Medicinae Universitatis Scientiae et Technologiae Huazhong J2 - Acta Medicinae Universitatis Scientiae et Technologiae Huazhong VL - 47 PY - 2018 IS - 6 SP - 755 EP - 758 PG - 4 SN - 1672-0741 UR - https://m2.mtmt.hu/api/publication/33034113 ID - 33034113 LA - Chinese DB - MTMT ER - TY - JOUR AU - Li, Wei AU - Qin, Jun AU - Wang, Hui AU - Chen, Liao-Bin TI - Research progress of epigenetic biomarkers in the early diagnosis and treatment of human diseases. JF - YICHUAN / HEREDITAS (BEIJING) J2 - YICHUAN / HEREDITAS (BEIJING) VL - 40 PY - 2018 IS - 2 SP - 104 EP - 115 PG - 12 SN - 0253-9772 DO - 10.16288/j.yczz.17-220 UR - https://m2.mtmt.hu/api/publication/33034108 ID - 33034108 LA - English DB - MTMT ER - TY - JOUR AU - Siddeek, B. AU - Mauduit, C. AU - Yzydorczyk, C. AU - Benahmed, M. AU - Simeoni, U. TI - At the heart of programming: the role of micro-RNAs JF - JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE J2 - J DEV ORIG HLTH DIS VL - 9 PY - 2018 IS - 6 SP - 615 EP - 631 PG - 17 SN - 2040-1744 DO - 10.1017/S2040174418000387 UR - https://m2.mtmt.hu/api/publication/30557864 ID - 30557864 N1 - Export Date: 22 June 2020 AB - Epidemiological and experimental observations tend to prove that environment, lifestyle or nutritional challenges influence heart functions together with genetic factors. Furthermore, when occurring during sensitive windows of heart development, these environmental challenges can induce an 'altered programming' of heart development and shape the future heart disease risk. In the etiology of heart diseases driven by environmental challenges, epigenetics has been highlighted as an underlying mechanism, constituting a bridge between environment and heart health. In particular, micro-RNAs which are involved in each step of heart development and functions seem to play a crucial role in the unfavorable programming of heart diseases. This review describes the latest advances in micro-RNA research in heart diseases driven by early exposure to challenges and discusses the use of micro-RNAs as potential targets in the reversal of the pathophysiology. LA - English DB - MTMT ER - TY - JOUR AU - Siddeek, Benazir AU - Mauduit, Claire AU - Simeoni, Umberto AU - Benahmed, Mohamed TI - Sperm epigenome as a marker of environmental exposure and lifestyle, at the origin of diseases inheritance JF - MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH J2 - MUTAT RES-REV MUTAT VL - 778 PY - 2018 SP - 38 EP - 44 PG - 7 SN - 1383-5742 DO - 10.1016/j.mrrev.2018.09.001 UR - https://m2.mtmt.hu/api/publication/30557866 ID - 30557866 N1 - Export Date: 22 June 2020 CODEN: MRRRF AB - Paternal exposure to environmental challenges plays a critical role in the offspring's future health and the transmission of acquired traits through generations. This review summarizes our current knowledge in the new field of epigenomic paternal transmission of health and disease. Epidemiological studies identified that paternal ageing or challenges (imbalanced diets, stress, toxicants, cigarette smoke, alcohol) increased the risk of offspring to develop diseases such as cancer, metabolic, cardiovascular, and neurological diseases. These data were confirmed and deepened in animal models of exposure to challenges including low-protein, low-folate, high-fat diets, exposure to chemicals such as pesticides and herbicides. Even though some toxicants have mutagenic effect on sperm DNA, changes in sperm epigenome seem to be a common thread between different types of challenges. Indeed, epigenetic changes (DNA methylation, chromatin remodeling, small non-coding RNA) in sperm are described as new mechanisms of intergenerational transmission as demonstrated for dioxin, for example. Those epimutations induce dysregulation in genes expression involved in key cellular pathways such as reactive oxygen species and genome stability regulation, in brain-derived neurotrophic factor, calcium and glucocorticoid signaling, and in lipid and glucose metabolism, leading to diseases in offspring. Finally, since each type of environmental challenges has its own signature by inducing epimutations at specific genomic loci, the sperm epigenome might be used as a biomarker in toxicological and risk assessments. LA - English DB - MTMT ER - TY - JOUR AU - Colvin, Kelley L AU - Yeager, Michael E TI - What people with Down Syndrome can teach us about cardiopulmonary disease JF - EUROPEAN RESPIRATORY REVIEW J2 - EUR RESPIR REV VL - 26 PY - 2017 IS - 143 PG - 16 SN - 0905-9180 DO - 10.1183/16000617.0098-2016 UR - https://m2.mtmt.hu/api/publication/26581822 ID - 26581822 N1 - Export Date: 22 June 2020 CODEN: EREWE LA - English DB - MTMT ER - TY - JOUR AU - Ai, Feng AU - Zhang, Yanwei AU - Peng, Bangtian TI - miR-20a regulates proliferation, differentiation and apoptosis in P19 cell model of cardiac differentiation by targeting Smoothened JF - BIOLOGY OPEN J2 - BIOL OPEN VL - 5 PY - 2016 IS - 9 SP - 1260 EP - 1265 PG - 6 SN - 2046-6390 DO - 10.1242/bio.019182 UR - https://m2.mtmt.hu/api/publication/26338034 ID - 26338034 N1 - Export Date: 22 June 2020 LA - English DB - MTMT ER - TY - JOUR AU - Radhakrishna, Uppala AU - Albayrak, Samet AU - Alpay-Savasan, Zeynep AU - Zeb, Amna AU - Turkoglu, Onur AU - Sobolewski, Paul AU - Bahado-Singh, Ray O TI - Genome-Wide DNA Methylation Analysis and Epigenetic Variations Associated with Congenital Aortic Valve Stenosis (AVS) JF - PLOS ONE J2 - PLOS ONE VL - 11 PY - 2016 IS - 5 PG - 13 SN - 1932-6203 DO - 10.1371/journal.pone.0154010 UR - https://m2.mtmt.hu/api/publication/26338035 ID - 26338035 N1 - Export Date: 22 June 2020 CODEN: POLNC LA - English DB - MTMT ER - TY - JOUR AU - Yang, S.-Y. AU - Wang, Y.-Q. AU - Gao, H.-M. AU - Wang, B. AU - He, Q. TI - The clinical value of circulating MIR-99a in plasma of patients with acute myocardial infarction JF - EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES J2 - EUR REV MED PHARMACOL SCI VL - 20 PY - 2016 IS - 24 SP - 5193 EP - 5197 PG - 5 SN - 1128-3602 UR - https://m2.mtmt.hu/api/publication/31356838 ID - 31356838 N1 - Export Date: 22 June 2020 CODEN: RESFD LA - English DB - MTMT ER -