@article{MTMT:33034103,
	title = {Identification by RNA-Seq of let-7 clusters as prenatal biomarkers for nonsyndromic cleft lip with palate},
	url = {https://m2.mtmt.hu/api/publication/33034103},
	author = {Jia, Shanshan and Zhang, Qiang and Wang, Yu and Wei, Xiaowei and Gu, Hui and Liu, Dan and Ma, Wei and He, Yiwen and Luo, Wenting and Yuan, Zhengwei},
	doi = {10.1111/nyas.14868},
	journal-iso = {ANN NY ACAD SCI},
	journal = {ANNALS OF THE NEW YORK ACADEMY OF SCIENCES},
	volume = {1516},
	unique-id = {33034103},
	issn = {0077-8923},
	keywords = {Prenatal Diagnosis; RNA sequencing; sonic hedgehog signaling; let-7 cluster; nonsyndromic cleft lip with palate},
	year = {2022},
	eissn = {1749-6632},
	pages = {234-246}
}

@article{MTMT:32098164,
	title = {Alterations of epigenetic landscape in Down syndrome carrying pregnancies: a systematic review of case-control studies},
	url = {https://m2.mtmt.hu/api/publication/32098164},
	author = {Reza Karimzadeh, Mohammad and Ehtesham, Naeim and Mortazavi, Deniz and Azhdari, Sara and Mosallaei, Meysam and Nezamnia, Maria},
	doi = {10.1016/j.ejogrb.2021.06.027},
	journal-iso = {EUR J OBSTET GYN R B (EJOG)},
	journal = {EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY},
	volume = {264},
	unique-id = {32098164},
	issn = {0301-2115},
	year = {2021},
	eissn = {1872-7654},
	pages = {189-199},
	orcid-numbers = {Ehtesham, Naeim/0000-0002-1769-6329}
}

@article{MTMT:3421053,
	title = {Noninvasive prenatal testing for congenital heart disease - cell-free nucleic acid and protein biomarkers in maternal blood.},
	url = {https://m2.mtmt.hu/api/publication/3421053},
	author = {Biró, Orsolya and Rigó, János and Nagy, Bálint},
	doi = {10.1080/14767058.2018.1508437},
	journal-iso = {J MATERN-FETAL NEO M},
	journal = {JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE},
	volume = {33},
	unique-id = {3421053},
	issn = {1476-7058},
	abstract = {CONTEXT: Congenital heart disease (CHD) is the most common fetal malformation. Prenatal ultrasonography is routinely applied for the screening of CHD but many factors influence its diagnostic accuracy. The introduction of new biomarkers could facilitate the identification of high-risk pregnancies. OBJECTIVE: In our review, our aim was to collect expression studies of cell-free nucleic acids and proteins in maternal circulation. Syndromic CHDs which can be detected by noninvasive prenatal testing (NIPT) techniques were also discussed. METHODS: PubMed and Web of Science databases were screened for studies where the levels of potential CHD biomarkers were measured in maternal blood samples. Available NIPT tests were collected from the providers' resources. RESULTS: There are nine CHD-associated chromosomal abnormalities, five aneuploidies, and four microdeletions, which are included in NIPT panels. We found eight articles from which five included the analysis of specific cell-free RNA expression and three measurements of protein levels. CONCLUSION: Most of the common heart-related chromosomal aberrations can be diagnosed by NIPT. Specific cell-free RNAs and circulating proteins seem to be potential biomarkers for fetal CHDs. The application of these new biomarkers could improve the detection rate at early pregnancy, making it possible to provide optimal perinatal and perioperative management.},
	year = {2020},
	eissn = {1476-4954},
	pages = {1044-1050},
	orcid-numbers = {Biró, Orsolya/0000-0002-4300-3602; Rigó, János/0000-0003-2762-6516; Nagy, Bálint/0000-0002-0295-185X}
}

@article{MTMT:33059695,
	title = {胎儿先天性心脏病无创性产前筛查分子 标志物的研究进展},
	url = {https://m2.mtmt.hu/api/publication/33059695},
	author = {Huang, Tianchu and Gu, Hui and Yuan, Zhengwei},
	doi = {10.3969/j.issn.2095-5340.2020.03.014},
	journal-iso = {J Dev Med},
	journal = {Journal of Developmental Medicine},
	volume = {8},
	unique-id = {33059695},
	issn = {2095-5340},
	year = {2020},
	pages = {267-271}
}

@article{MTMT:33059706,
	title = {Clinical study of laparoscopic Lich-Gregoir technique for the treatment of primary vesicoureteral reflux in children},
	url = {https://m2.mtmt.hu/api/publication/33059706},
	author = {Ma, Lifei and Zhou, Huixia and Zhou, Xiaoguang and Cao, Hualin and Liu, Dehong and Tao, Tian},
	doi = {10.3969/j.issn.2095-5340.2020.03.013},
	journal-iso = {J Dev Med},
	journal = {Journal of Developmental Medicine},
	volume = {8},
	unique-id = {33059706},
	issn = {2095-5340},
	year = {2020},
	pages = {262-271}
}

@article{MTMT:31710184,
	title = {Circulating Cell-Free Nucleic Acids as Epigenetic Biomarkers in Precision Medicine},
	url = {https://m2.mtmt.hu/api/publication/31710184},
	author = {Rahat, Beenish and Ali, Taqveema and Sapehia, Divika and Mahajan, Aatish and Kaur, Jyotdeep},
	doi = {10.3389/fgene.2020.00844},
	journal-iso = {FRONT GENET},
	journal = {FRONTIERS IN GENETICS},
	volume = {11},
	unique-id = {31710184},
	abstract = {The circulating cell-free nucleic acids (ccfNAs) are a mixture of single- or double-stranded nucleic acids, released into the blood plasma/serum by different tissues via apoptosis, necrosis, and secretions. Under healthy conditions, ccfNAs originate from the hematopoietic system, whereas under various clinical scenarios, the concomitant tissues release ccfNAs into the bloodstream. These ccfNAs include DNA, RNA, microRNA (miRNA), long non-coding RNA (lncRNA), fetal DNA/RNA, and mitochondrial DNA/RNA, and act as potential biomarkers in various clinical conditions. These are associated with different epigenetic modifications, which show disease-related variations and so finding their role as epigenetic biomarkers in clinical settings. This field has recently emerged as the latest advance in precision medicine because of its clinical relevance in diagnostic, prognostic, and predictive values. DNA methylation detected in ccfDNA has been widely used in personalized clinical diagnosis; furthermore, there is also the emerging role of ccfRNAs like miRNA and lncRNA as epigenetic biomarkers. This review focuses on the novel approaches for exploring ccfNAs as epigenetic biomarkers in personalized clinical diagnosis and prognosis, their potential as therapeutic targets and disease progression monitors, and reveals the tremendous potential that epigenetic biomarkers present to improve precision medicine. We explore the latest techniques for both quantitative and qualitative detection of epigenetic modifications in ccfNAs. The data on epigenetic modifications on ccfNAs are complex and often milieu-specific posing challenges for its understanding. Artificial intelligence and deep networks are the novel approaches for decoding complex data and providing insight into the decision-making in precision medicine.},
	keywords = {SERUM; Autoimmune Diseases; cancer diagnosis; Precision Medicine; epigenetic biomarkers; circulating nucleic acids in plasma; prenatal and genetic diagnostics; circulating cell free nucleic acids},
	year = {2020},
	eissn = {1664-8021},
	orcid-numbers = {Mahajan, Aatish/0000-0002-5064-6921}
}

@article{MTMT:31782877,
	title = {Non-Coding RNAs as Blood-Based Biomarkers in Cardiovascular Disease},
	url = {https://m2.mtmt.hu/api/publication/31782877},
	author = {Videira, Raquel Figuinha and da Costa Martins, Paula A. and Falcão-Pires, Inês},
	doi = {10.3390/ijms21239285},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {21},
	unique-id = {31782877},
	issn = {1661-6596},
	year = {2020},
	eissn = {1422-0067}
}

@article{MTMT:30758075,
	title = {Cell-free nucleic acids in prenatal diagnosis and pregnancy-associated diseases},
	url = {https://m2.mtmt.hu/api/publication/30758075},
	author = {Nagy, Bálint},
	journal-iso = {E JIFCC},
	journal = {ELECTRONIC JOURNAL OF THE INTERNATIONAL FEDERATION OF CLINICAL CHEMISTRY AND LABORATORY MEDICINE},
	volume = {30},
	unique-id = {30758075},
	issn = {1650-3414},
	abstract = {There is a great effort to find out the biological role of cell-free nucleic acids (cfNAs). They are considered very promising targets in the diagnosis of genetic diseases. Non-invasive sampling (liquid biopsy) has recently become a very popular method, and new molecular biological techniques have been developed for these types of samples. Application of next-generation sequencing (NGS) and massively parallel sequencing (MPS) is spreading fast. These are the part of the arsenal of the modern prenatal genetic diagnostic laboratories by now. Cell-free DNA based noninvasive prenatal testing accounts for more than half of the prenatal genetic tests performed, it is gradually replacing the invasive amniocentesis or chorionic villus sample-based diagnostics. Besides that, new non-coding RNAs are taking more attention: microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) are in the focus of the clinical research to detect the most common pregnancy-associated diseases, like preeclampsia, fetal growth restriction, congenital heart diseases and gestational diabetes. The research is at advanced stage on the use of microRNAs, while lncRNAs and circRNAs are still promising targets. In this review, comprehensive information is given about the recent developments on this field.},
	year = {2019},
	pages = {215-223},
	orcid-numbers = {Nagy, Bálint/0000-0002-0295-185X}
}

@{MTMT:33034100,
	title = {The fetus and the neonate: Immediate, short-, and long-term impact},
	url = {https://m2.mtmt.hu/api/publication/33034100},
	author = {Simeoni, Umberto and Saliba, Elie},
	booktitle = {New Technologies and Perinatal Medicine: Prediction and Prevention of Pregnancy Complications},
	unique-id = {33034100},
	year = {2019},
	pages = {56-59}
}

@article{MTMT:31356837,
	title = {Mature miR-99a upregulation in the amniotic fluid samples from female fetus down syndrome pregnancies: A pilot study},
	url = {https://m2.mtmt.hu/api/publication/31356837},
	author = {Vizitiu, A.-C. and Stambouli, D. and Pavel, A.-G. and Muresan, M.-C. and Anastasiu, D.M. and Bejinar, C. and Alexa, A. and Marian, C. and Sirbu, I.O. and Sima, L.},
	doi = {10.3390/medicina55110728},
	journal-iso = {MED LITH},
	journal = {MEDICINA-LITHUANIA},
	volume = {55},
	unique-id = {31356837},
	issn = {1010-660X},
	year = {2019},
	eissn = {1648-9144}
}

@article{MTMT:27592695,
	title = {Potential role of "omics" technique in prenatal diagnosis of congenital heart defects},
	url = {https://m2.mtmt.hu/api/publication/27592695},
	author = {Chen, Lizhu and Guan, Johnny and Wei, Qiuju and Yuan, Zhengwei and Zhang, Mo},
	doi = {10.1016/j.cca.2018.04.011},
	journal-iso = {CLIN CHIM ACTA},
	journal = {CLINICA CHIMICA ACTA},
	volume = {482},
	unique-id = {27592695},
	issn = {0009-8981},
	year = {2018},
	eissn = {1873-3492},
	pages = {185-190}
}

@article{MTMT:33034113,
	title = {21q21.1-21.3 micrornas},
	url = {https://m2.mtmt.hu/api/publication/33034113},
	author = {Hu, Yue and Xu, Yuanyuan and Hao, Yan and Meng, Xianfang},
	journal-iso = {Acta Medicinae Universitatis Scientiae et Technologiae Huazhong},
	journal = {Acta Medicinae Universitatis Scientiae et Technologiae Huazhong},
	volume = {47},
	unique-id = {33034113},
	issn = {1672-0741},
	year = {2018},
	pages = {755-758}
}

@article{MTMT:33034108,
	title = {Research progress of epigenetic biomarkers in the early diagnosis and treatment of human diseases.},
	url = {https://m2.mtmt.hu/api/publication/33034108},
	author = {Li, Wei and Qin, Jun and Wang, Hui and Chen, Liao-Bin},
	doi = {10.16288/j.yczz.17-220},
	journal-iso = {YICHUAN / HEREDITAS (BEIJING)},
	journal = {YICHUAN / HEREDITAS (BEIJING)},
	volume = {40},
	unique-id = {33034108},
	issn = {0253-9772},
	year = {2018},
	pages = {104-115}
}

@article{MTMT:30557864,
	title = {At the heart of programming: the role of micro-RNAs},
	url = {https://m2.mtmt.hu/api/publication/30557864},
	author = {Siddeek, B. and Mauduit, C. and Yzydorczyk, C. and Benahmed, M. and Simeoni, U.},
	doi = {10.1017/S2040174418000387},
	journal-iso = {J DEV ORIG HLTH DIS},
	journal = {JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE},
	volume = {9},
	unique-id = {30557864},
	issn = {2040-1744},
	abstract = {Epidemiological and experimental observations tend to prove that environment, lifestyle or nutritional challenges influence heart functions together with genetic factors. Furthermore, when occurring during sensitive windows of heart development, these environmental challenges can induce an 'altered programming' of heart development and shape the future heart disease risk. In the etiology of heart diseases driven by environmental challenges, epigenetics has been highlighted as an underlying mechanism, constituting a bridge between environment and heart health. In particular, micro-RNAs which are involved in each step of heart development and functions seem to play a crucial role in the unfavorable programming of heart diseases. This review describes the latest advances in micro-RNA research in heart diseases driven by early exposure to challenges and discusses the use of micro-RNAs as potential targets in the reversal of the pathophysiology.},
	keywords = {REVERSAL; programming; micro-RNAs; cardio-metabolic dysfunctions},
	year = {2018},
	eissn = {2040-1752},
	pages = {615-631}
}

@article{MTMT:30557866,
	title = {Sperm epigenome as a marker of environmental exposure and lifestyle, at the origin of diseases inheritance},
	url = {https://m2.mtmt.hu/api/publication/30557866},
	author = {Siddeek, Benazir and Mauduit, Claire and Simeoni, Umberto and Benahmed, Mohamed},
	doi = {10.1016/j.mrrev.2018.09.001},
	journal-iso = {MUTAT RES-REV MUTAT},
	journal = {MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH},
	volume = {778},
	unique-id = {30557866},
	issn = {1383-5742},
	abstract = {Paternal exposure to environmental challenges plays a critical role in the offspring's future health and the transmission of acquired traits through generations. This review summarizes our current knowledge in the new field of epigenomic paternal transmission of health and disease. Epidemiological studies identified that paternal ageing or challenges (imbalanced diets, stress, toxicants, cigarette smoke, alcohol) increased the risk of offspring to develop diseases such as cancer, metabolic, cardiovascular, and neurological diseases. These data were confirmed and deepened in animal models of exposure to challenges including low-protein, low-folate, high-fat diets, exposure to chemicals such as pesticides and herbicides. Even though some toxicants have mutagenic effect on sperm DNA, changes in sperm epigenome seem to be a common thread between different types of challenges. Indeed, epigenetic changes (DNA methylation, chromatin remodeling, small non-coding RNA) in sperm are described as new mechanisms of intergenerational transmission as demonstrated for dioxin, for example. Those epimutations induce dysregulation in genes expression involved in key cellular pathways such as reactive oxygen species and genome stability regulation, in brain-derived neurotrophic factor, calcium and glucocorticoid signaling, and in lipid and glucose metabolism, leading to diseases in offspring. Finally, since each type of environmental challenges has its own signature by inducing epimutations at specific genomic loci, the sperm epigenome might be used as a biomarker in toxicological and risk assessments.},
	keywords = {SPERM; Environment; epigenome; intergenerational},
	year = {2018},
	eissn = {1388-2139},
	pages = {38-44}
}

@article{MTMT:26581822,
	title = {What people with Down Syndrome can teach us about cardiopulmonary disease},
	url = {https://m2.mtmt.hu/api/publication/26581822},
	author = {Colvin, Kelley L and Yeager, Michael E},
	doi = {10.1183/16000617.0098-2016},
	journal-iso = {EUR RESPIR REV},
	journal = {EUROPEAN RESPIRATORY REVIEW},
	volume = {26},
	unique-id = {26581822},
	issn = {0905-9180},
	year = {2017},
	eissn = {1600-0617}
}

@article{MTMT:26338034,
	title = {miR-20a regulates proliferation, differentiation and apoptosis in P19 cell model of cardiac differentiation by targeting Smoothened},
	url = {https://m2.mtmt.hu/api/publication/26338034},
	author = {Ai, Feng and Zhang, Yanwei and Peng, Bangtian},
	doi = {10.1242/bio.019182},
	journal-iso = {BIOL OPEN},
	journal = {BIOLOGY OPEN},
	volume = {5},
	unique-id = {26338034},
	issn = {2046-6390},
	year = {2016},
	eissn = {2046-6390},
	pages = {1260-1265}
}

@article{MTMT:26338035,
	title = {Genome-Wide DNA Methylation Analysis and Epigenetic Variations Associated with Congenital Aortic Valve Stenosis (AVS)},
	url = {https://m2.mtmt.hu/api/publication/26338035},
	author = {Radhakrishna, Uppala and Albayrak, Samet and Alpay-Savasan, Zeynep and Zeb, Amna and Turkoglu, Onur and Sobolewski, Paul and Bahado-Singh, Ray O},
	doi = {10.1371/journal.pone.0154010},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {11},
	unique-id = {26338035},
	issn = {1932-6203},
	year = {2016},
	eissn = {1932-6203}
}

@article{MTMT:31356838,
	title = {The clinical value of circulating MIR-99a in plasma of patients with acute myocardial infarction},
	url = {https://m2.mtmt.hu/api/publication/31356838},
	author = {Yang, S.-Y. and Wang, Y.-Q. and Gao, H.-M. and Wang, B. and He, Q.},
	journal-iso = {EUR REV MED PHARMACOL SCI},
	journal = {EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES},
	volume = {20},
	unique-id = {31356838},
	issn = {1128-3602},
	year = {2016},
	eissn = {2284-0729},
	pages = {5193-5197}
}