TY - JOUR AU - Cinege, Gyöngyi Ilona AU - Magyar, Lilla Brigitta AU - Kovács, Henrietta AU - Varga, Viktória AU - Bodai, László AU - Zsindely, Nóra AU - Nagy, Gábor AU - Hegedűs, Zoltán AU - Hultmark, Dan AU - Andó, István TI - Distinctive features of Zaprionus indianus hemocyte differentiation and function revealed by transcriptomic analysis JF - FRONTIERS IN IMMUNOLOGY J2 - FRONT IMMUNOL VL - 14 PY - 2023 PG - 14 SN - 1664-3224 DO - 10.3389/fimmu.2023.1322381 UR - https://m2.mtmt.hu/api/publication/34446740 ID - 34446740 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Verster, Kirsten I. AU - Cinege, Gyöngyi Ilona AU - Lipinszki, Zoltán AU - Magyar, Lilla Brigitta AU - Kurucz, Judit Éva AU - Tarnopol, Rebecca L. AU - Ábrahám, Edit AU - Darula, Zsuzsanna AU - Karageorgi, Marianthi AU - Tamsil, Josephine A. AU - Akalu, Saron M. AU - Andó, István AU - Whiteman, Noah K. TI - Evolution of insect innate immunity through domestication of bacterial toxins JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 120 PY - 2023 IS - 16 PG - 9 SN - 0027-8424 DO - 10.1073/pnas.2218334120 UR - https://m2.mtmt.hu/api/publication/33744872 ID - 33744872 N1 - Department of Integrative Biology, University of California, Berkeley, CA 94720, United States Innate Immunity Group, Institute of Genetics, Biological Research Centre, Eötvös Loránd Research Network, Szeged, 6726, Hungary MTA SZBK Lendület Laboratory of Cell Cycle Regulation, Institute of Biochemistry, Biological Research Centre, Eötvös Loránd Research Network, Szeged, 6726, Hungary Doctoral School of Biology, University of Szeged, Szeged, 6720, Hungary Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, United States Single Cell Omics Advanced Core Facility, Hungarian Centre of Excellence for Molecular Medicine, Szeged, 6728, Hungary Laboratory of Proteomics Research, Biological Research Centre, Eötvös Loránd Research Network, Szeged, 6726, Hungary Department of Biology, Stanford University, Palo Alto, CA 94305, United States Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, United States Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, United States Cited By :2 Export Date: 10 July 2023 CODEN: PNASA Correspondence Address: Andó, I.; Innate Immunity Group, Hungary; email: ando@brc.hu Correspondence Address: Whiteman, N.K.; Department of Integrative Biology, United States; email: whiteman@berkeley.edu AB - Toxin cargo genes are often horizontally transferred by phages between bacterial species and are known to play an important role in the evolution of bacterial pathogenesis. Here, we show how these same genes have been horizontally transferred from phage or bacteria to animals and have resulted in novel adaptations. We discovered that two widespread bacterial genes encoding toxins of animal cells, cytolethal distending toxin subunit B ( cdtB ) and apoptosis-inducing protein of 56 kDa ( aip56) , were captured by insect genomes through horizontal gene transfer from bacteria or phages. To study the function of these genes in insects, we focused on Drosophila ananassae as a model. In the D. ananassae subgroup species, cdtB and aip56 are present as singular ( cdtB ) or fused copies ( cdtB::aip56 ) on the second chromosome. We found that cdtB and aip56 genes and encoded proteins were expressed by immune cells, some proteins were localized to the wasp embryo’s serosa, and their expression increased following parasitoid wasp infection. Species of the ananassae subgroup are highly resistant to parasitoid wasps, and we observed that D. ananassae lines carrying null mutations in cdtB and aip56 toxin genes were more susceptible to parasitoids than the wild type. We conclude that toxin cargo genes were captured by these insects millions of years ago and integrated as novel modules into their innate immune system. These modules now represent components of a heretofore undescribed defense response and are important for resistance to parasitoid wasps. Phage or bacterially derived eukaryotic toxin genes serve as macromutations that can spur the instantaneous evolution of novelty in animals. LA - English DB - MTMT ER - TY - JOUR AU - Cinege, Gyöngyi Ilona AU - Magyar, Lilla Brigitta AU - Kovács, Attila Lajos AU - Lerner, Zita AU - Juhász, Gábor AU - Lukacsovich, David AU - Winterer, Jochen AU - Lukacsovich, Tamás AU - Hegedűs, Zoltán AU - Kurucz, Judit Éva AU - Hultmark, Dan AU - Földy, Csaba AU - Andó, István TI - Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids JF - JOURNAL OF INNATE IMMUNITY J2 - J INNATE IMMUN VL - 14 PY - 2022 IS - 4 SP - 335 EP - 354 PG - 20 SN - 1662-811X DO - 10.1159/000520110 UR - https://m2.mtmt.hu/api/publication/32524824 ID - 32524824 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Gwokyalya, Rehemah AU - Herren, Jeremy K. K. AU - Weldon, Christopher W. W. AU - Khamis, Fathiya M. M. AU - Ndlela, Shepard AU - Mohamed, Samira Abuelgasim TI - Differential immune responses in new and old fruit fly-parasitoid associations: Implications for their management JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 13 PY - 2022 PG - 16 SN - 1664-042X DO - 10.3389/fphys.2022.945370 UR - https://m2.mtmt.hu/api/publication/33181516 ID - 33181516 AB - The oriental fruit fly, Bactrocera dorsalis (Hendel), and marula fruit fly, Ceratitis cosyra (Walker), are major fruit-infesting tephritids across sub-Saharan Africa. Biological control of these pests using parasitic wasps has been widely adopted but with varying levels of success. Most studies investigating host-parasitoid models have focused on functional and evolutionary aspects leaving a knowledge gap about the physiological mechanisms underpinning the efficacy of parasitoids as biocontrol agents of tephritids. To better understand these physiological mechanisms, we investigated changes in the cellular immune responses of C. cosyra and B. dorsalis when exposed to the parasitic wasps, Diachasmimorpha longicaudata (Ashmaed) and Psyttalia cosyrae (Wilkinson). We found that B. dorsalis was more resistant to parasitisation, had a higher hemocyte count, and encapsulated more parasitoid eggs compared to C. cosyra, achieving up to 100% encapsulation when exposed to P. cosyrae. Exposing B. dorsalis to either parasitoid species induced the formation of a rare cell type, the giant multinucleated hemocyte, which was not observed in C. cosyra. Furthermore, compared to P. cosyrae-parasitized larvae, those of both host species parasitized by D. longicaudata had lower encapsulation rates, hemocyte counts and spreading abilities and yielded a higher number of parasitoid progeny with the highest parasitoid emergence (72.13%) recorded in C. cosyra. These results demonstrate that cellular immune responses are central to host-parasitoid interaction in tephritid fruit flies and further suggest that D. longicaudata presents greater potential as a biocontrol agent of B. dorsalis and C. cosyra in horticultural cropping systems. LA - English DB - MTMT ER - TY - JOUR AU - Hultmark, Dan AU - Andó, István TI - Hematopoietic plasticity mapped in Drosophila and other insects JF - ELIFE J2 - ELIFE VL - 11 PY - 2022 PG - 36 SN - 2050-084X DO - 10.7554/eLife.78906 UR - https://m2.mtmt.hu/api/publication/33039275 ID - 33039275 N1 - Funding Agency and Grant Number: Vetenskapsradet [2018-05114]; Hungarian Science Foundation [K135877] Funding text: Vetenskapsradet 2018-05114 Dan HultmarkHungarian Science Foundation K135877 Istvan AndoThe funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. LA - English DB - MTMT ER - TY - JOUR AU - von, Bredow Y.M. AU - Müller, A. AU - Popp, P.F. AU - Iliasov, D. AU - von, Bredow C.-R. TI - Characterization and mode of action analysis of black soldier fly (Hermetia illucens) larva-derived hemocytes JF - INSECT SCIENCE J2 - INSECT SCI VL - 29 PY - 2022 IS - 4 SP - 1071 EP - 1095 PG - 25 SN - 1672-9609 DO - 10.1111/1744-7917.12977 UR - https://m2.mtmt.hu/api/publication/32601764 ID - 32601764 N1 - Justus-Liebig-Universität Gießen, Institut für Allgemeine Zoologie und Entwicklungsbiologie, Zelluläre Erkennungs– und Abwehrprozesse, Gießen, Germany Technische Universität Dresden, Fakultät Biologie, Institut für Zoologie, Dresden, Germany Technische Universität Dresden, Fakultät Biologie, Institut für Mikrobiologie, Dresden, Germany Philipp F. Popp, Institute for Biology-Bacterial Physiology, Humboldt-Universität zu Berlin, Berlin, Germany Export Date: 19 January 2022 Correspondence Address: von Bredow, C.-R.; Technische Universität Dresden, Germany; email: christoph.von.bredow@mail.de AB - With the growing importance of the black soldier fly (Hermetia illucens) for both sustainable food production and waste management as well as for science, a great demand of understanding its immune system arises. Here, we present the first description of the circulating larval hemocytes with special emphasis on uptake of microorganisms and distinguishing hemocyte types. With histological, zymographic, and cytometric methods and with a set of hemocyte binding lectins and antibodies, the hemocytes of H. illucens are identified as plasmatocytes, crystal cells, and putative prohemocytes. Total hemocyte counts (THC) are determined, and methods for THC determination are compared. Approximately 1100 hemocytes per microliter hemolymph are present in naive animals, while hemocyte density decreases dramatically shortly after wounding, indicating a role of hemocytes in response to wounding (and immune response in general). The determination of the relative abundance of each hemocyte type (differential hemocyte count, DHC) revealed that plasmatocytes are highly abundant, whereas prohemocytes and crystal cells make up only a small percentage of the circulating cells. Plasmatocytes are not only the most abundant but also the professional phagocytes in H. illucens. They rapidly engulf and take up bacteria both in vivo and in vitro, indicating a very potent cellular defense against invading pathogens. Larger bioparticles such as yeasts are also removed from circulation by phagocytosis, but slower than bacteria. This is the first analysis of the potent cellular immune response in the black soldier fly, and a first toolbox that helps to identify hemocyte (types) is presented. © 2021 The Authors. Insect Science published by John Wiley & Sons Australia, Ltd on behalf of Institute of Zoology, Chinese Academy of Sciences LA - English DB - MTMT ER - TY - JOUR AU - Wertheim, B. TI - Adaptations and counter-adaptations in Drosophila host–parasitoid interactions: advances in the molecular mechanisms JF - CURRENT OPINION IN INSECT SCIENCE J2 - CURR OPIN INSECT SCI VL - 51 PY - 2022 SN - 2214-5745 DO - 10.1016/j.cois.2022.100896 UR - https://m2.mtmt.hu/api/publication/32876692 ID - 32876692 N1 - Export Date: 14 June 2022 AB - Both hosts and parasitoids evolved a diverse array of traits and strategies for their antagonistic interactions, affecting their chances of encounter, attack and survival after parasitoid attack. This review summarizes the recent progress that has been made in elucidating the molecular mechanisms of these adaptations and counter-adaptations in various Drosophila host–parasitoid interactions. For the hosts, it focuses on the neurobiological and genetic control of strategies in Drosophila adults and larvae of avoidance or escape behaviours upon sensing the parasitoids, and the immunological defences involving diverse classes of haemocytes. For the parasitoids, it highlights their behavioural strategies in host finding, as well as the rich variety of venom components that evolved and were partially acquired through horizontal gene transfer. Recent studies revealed the mechanisms by which these venom components manipulate their parasitized hosts in exhibiting escape behaviour to avoid superparasitism, and their counter-strategies to evade or obstruct the hosts’ immunological defences. © 2022 The Author(s) LA - English DB - MTMT ER - TY - JOUR AU - Csordás, Gábor AU - Gábor, Erika AU - Honti, Viktor TI - There and back again: The mechanisms of differentiation and transdifferentiation in Drosophila blood cells JF - DEVELOPMENTAL BIOLOGY J2 - DEV BIOL VL - 469 PY - 2021 SP - 135 EP - 143 PG - 9 SN - 0012-1606 DO - 10.1016/j.ydbio.2020.10.006 UR - https://m2.mtmt.hu/api/publication/31743832 ID - 31743832 N1 - Cited By :5 Export Date: 14 June 2022 CODEN: DEBIA LA - English DB - MTMT ER - TY - JOUR AU - Herbath, M. AU - Fabry, Z. AU - Sandor, M. TI - Current concepts in granulomatous immune responses JF - BIOLOGIA FUTURA J2 - BIOL FUTURA VL - 72 PY - 2021 IS - 1 SP - 61 EP - 68 PG - 8 SN - 2676-8615 DO - 10.1007/s42977-021-00077-1 UR - https://m2.mtmt.hu/api/publication/32000172 ID - 32000172 N1 - Export Date: 5 May 2021 Correspondence Address: Herbath, M.; Department of Pathology and Laboratory Medicine, United States; email: herbath@wisc.edu Export Date: 10 May 2021 Correspondence Address: Herbath, M.; Department of Pathology and Laboratory Medicine, United States; email: herbath@wisc.edu AB - Persistent irritants that are resistant to innate and cognate immunity induce granulomas. These macrophage-dominated lesions that partially isolate the healthy tissue from the irritant and the irritant induced inflammation. Particles, toxins, autoantigens and infectious agents can induce granulomas. The corresponding lesions can be protective for the host but they can also cause damage and such damage has been associated with the pathology of more than a hundred human diseases. Recently, multiple molecular mechanisms underlying how normal macrophages transform into granuloma-inducing macrophages have been discovered and new information has been gathered, indicating how these lesions are initiated, spread and regulated. In this review, differences between the innate and cognate granuloma pathways are discussed by summarizing how the dendritic cell-T cell axis changes granulomatous immunity. Granuloma lesions are highly dynamic and depend on continuous cell replacement. This feature provides new therapeutic approaches to treat granulomatous diseases. © 2021, Akadémiai Kiadó Zrt. LA - English DB - MTMT ER - TY - JOUR AU - Salazar-Jaramillo, L. AU - Wertheim, B. TI - Does Drosophila sechellia escape parasitoid attack by feeding on a toxic resource? JF - PEERJ J2 - PEERJ VL - 9 PY - 2021 SN - 2167-8359 DO - 10.7717/peerj.10528 UR - https://m2.mtmt.hu/api/publication/31866341 ID - 31866341 N1 - Export Date: 11 February 2021 Correspondence Address: Salazar-Jaramillo, L.; Vidarium-Nutrition, Colombia; email: lauraalazar@gmail.com AB - Host shifts can drastically change the selective pressures that animals experience from their environment. Drosophila sechellia is a species restricted to the Seychelles islands, where it specializes on the fruit Morinda citrifolia (noni). This fruit is known to be toxic to closely related Drosophila species, including D. melanogaster and D. simulans, releasing D. sechellia from interspecific competition when breeding on this substrate. Previously, we showed that larvae of D. sechellia are unable to mount an effective immunological response against wasp attack, while larvae of closely-related species can defend themselves from parasitoid attack by melanotic encapsulation. We hypothesized that this inability constitutes a trait loss due to a reduced risk of parasitoid attack in noni. Here we present a lab experiment and field survey aimed to test the hypothesis that specialization on noni has released D. sechellia from the antagonistic interaction with its larval parasitoids. Our results from the lab experiment suggest that noni may be harmful to parasitoid wasps. Our results from the field survey indicate that D. sechellia was found in ripe noni, whereas another Drosophila species, D. malerkotliana, was present in unripe and overripe stages. Parasitic wasps of the species Leptopilina boulardi emerged from overripe noni, where D. malerkotliana was the most abundant host, but not from ripe noni. These results indicate that the specialization of D. sechellia on noni has indeed drastically altered its ecological interactions, leading to a relaxation in the selection pressure to maintain parasitoid resistance. Copyright 2021 Salazar-Jaramillo and Wertheim LA - English DB - MTMT ER - TY - JOUR AU - Yang, L. AU - Qiu, L.-M. AU - Fang, Q. AU - Stanley, D.W. AU - Ye, G.-Y. TI - Cellular and humoral immune interactions between Drosophila and its parasitoids JF - INSECT SCIENCE J2 - INSECT SCI VL - 28 PY - 2021 IS - 5 SP - 1208 EP - 1227 PG - 20 SN - 1672-9609 DO - 10.1111/1744-7917.12863 UR - https://m2.mtmt.hu/api/publication/31596046 ID - 31596046 N1 - State Key Laboratory of Rice Biology & Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China USDA Agricultural Research Service, Biological Control of Insects Research Laboratory, Columbia, MO, United States Cited By :28 Export Date: 15 February 2024 Correspondence Address: Ye, G.-Y.; State Key Laboratory of Rice Biology & Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, China; email: chu@zju.edu.cn AB - The immune interactions occurring between parasitoids and their host insects, especially in Drosophila–wasp models, have long been the research focus of insect immunology and parasitology. Parasitoid infestation in Drosophila is counteracted by its multiple natural immune defense systems, which include cellular and humoral immunity. Occurring in the hemocoel, cellular immune responses involve the proliferation, differentiation, migration and spreading of host hemocytes and parasitoid encapsulation by them. Contrastingly, humoral immune responses rely more heavily on melanization and on the Toll, Imd and Jak/Stat immune pathways associated with antimicrobial peptides along with stress factors. On the wasps’ side, successful development is achieved by introducing various virulence factors to counteract immune responses of Drosophila. Some or all of these factors manipulate the host's immunity for successful parasitism. Here we review current knowledge of the cellular and humoral immune interactions between Drosophila and its parasitoids, focusing on the defense mechanisms used by Drosophila and the strategies evolved by parasitic wasps to outwit it. © 2020 Institute of Zoology, Chinese Academy of Sciences LA - English DB - MTMT ER - TY - JOUR AU - Cinege, Gyöngyi Ilona AU - Lerner, Zita AU - Magyar, Lilla Brigitta AU - Soós, Bálint AU - Tóth, Renáta AU - Kristó, Ildikó AU - Vilmos, Péter AU - Juhász, Gábor AU - Kovács, Attila Lajos AU - Hegedűs, Zoltán AU - Sensen, Christoph W. AU - Kurucz, Judit Éva AU - Andó, István TI - Cellular Immune Response Involving Multinucleated Giant Hemocytes with Two-Step Genome Amplification in the Drosophilid Zaprionus indianus JF - JOURNAL OF INNATE IMMUNITY J2 - J INNATE IMMUN VL - 12 PY - 2020 IS - 3 SP - 257 EP - 272 PG - 16 SN - 1662-811X DO - 10.1159/000502646 UR - https://m2.mtmt.hu/api/publication/30819399 ID - 30819399 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Gábor, Erika AU - Cinege, Gyöngyi Ilona AU - Csordás, Gábor AU - Rusvai, Miklós AU - Honti, Viktor AU - Kolics, Balázs AU - Török, Tibor AU - Williams, Michael J AU - Kurucz, Judit Éva AU - Andó, István TI - Identification of reference markers for characterizing honey bee (Apis mellifera) hemocyte classes JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 109 PY - 2020 SP - 103701 PG - 5 SN - 0145-305X DO - 10.1016/j.dci.2020.103701 UR - https://m2.mtmt.hu/api/publication/31302837 ID - 31302837 N1 - The publication is supported by the EFOP-3.6.3-VEKOP-16-2017-00008 project. The project is co-financed by the European Union and the European Social Fund. Immunology Unit, Institute of Genetics, Biological Research Centre, P.O.Box 521, Szeged, H-6701, Hungary University of Veterinary Medicine, István u. 2., Budapest, 1078, Hungary Department of Plant Science and Biotechnology, University of Pannonia, Georgikon Faculty, Deák F. u. 16., Keszthely, 8360, Hungary Department of Genetics, University of Szeged, Közép Fasor 52, Szeged, 6726, Hungary Functional Pharmacology, Department of Neuroscience, Uppsala University, Husargatan 3, Box 593, Uppsala, 751 24, Sweden Export Date: 10 December 2020 CODEN: DCIMD Correspondence Address: Andó, I.; Immunology Unit, Institute of Genetics, Biological Research Centre, P.O.Box 521, Hungary; email: ando@brc.hu AB - Cell mediated immunity of the honey bee (Apis mellifera) involves the activity of several hemocyte populations, currently defined by morphological features and lectin binding characteristics. The objective of the present study was to identify molecular markers capable of characterizing subsets of honey bee hemocytes. We developed and employed monoclonal antibodies with restricted reactions to functionally distinct hemocyte subpopulations. Melanizing cells, known as oenocytoids, were defined by an antibody to prophenoloxidase, aggregating cells were identified by the expression of Hemolectin, and phagocytic cells were identified by a marker expressed on granulocytes. We anticipate that this combination of antibodies not only allows for the detection of functionally distinct hemocyte subtypes, but will help to further the exploration of hematopoietic compartments, as well as reveal details of the honey bee cellular immune defense against parasites and microbes. LA - English DB - MTMT ER - TY - JOUR AU - Kim-Jo, Chami AU - Gatti, Jean-Luc AU - Poirie, Marylene TI - Drosophila Cellular Immunity Against Parasitoid Wasps: A Complex and Time-Dependent Process JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 10 PY - 2019 PG - 8 SN - 1664-042X DO - 10.3389/fphys.2019.00603 UR - https://m2.mtmt.hu/api/publication/30907275 ID - 30907275 N1 - Cited By :19 Export Date: 19 January 2022 Correspondence Address: Poirié, M.; INRA, France; email: marylene.poirie@univ-cotedazur.fr AB - Host-parasitoid interactions are among the most studied interactions between invertebrates because of their fundamental interest - the evolution of original traits in parasitoids - and applied, parasitoids being widely used in biological control. Immunity, and in particular cellular immunity, is central in these interactions, the host encapsulation response being specific for large foreign bodies such as parasitoid eggs. Although already well studied in this species, recent data on Drosophila melanogaster have unquestionably improved knowledge of invertebrate cellular immunity. At the same time, the venomics of parasitoids has expanded, notably those of Drosophila. Here, we summarize and discuss these advances, with a focus on an emerging "time-dependent" view of interactions outcome at the intra- and interspecific level. We also present issues still in debate and prospects for study. Data on the Drosophila-parasitoid model paves the way to new concepts in insect immunity as well as parasitoid wasp strategies to overcome it. LA - English DB - MTMT ER - TY - JOUR AU - Bozler, Julianna AU - Kacsoh, Balint Z AU - Bosco, Giovanni TI - Nematocytes: Discovery and characterization of a novel anculeate hemocyte in Drosophila falleni and Drosophila phalerata JF - PLOS ONE J2 - PLOS ONE VL - 12 PY - 2017 IS - 11 PG - 17 SN - 1932-6203 DO - 10.1371/journal.pone.0188133 UR - https://m2.mtmt.hu/api/publication/27048633 ID - 27048633 N1 - Cited By :3 Export Date: 19 January 2022 CODEN: POLNC Correspondence Address: Bozler, J.; Department of Molecular and Systems Biology, United States; email: Julianna.E.Bozler.GR@Dartmouth.edu LA - English DB - MTMT ER - TY - JOUR AU - Gábor, Erika AU - Cinege, Gyöngyi Ilona AU - Csordás, Gábor AU - Török, Tibor AU - Medzihradszky F., Katalin AU - Darula, Zsuzsanna AU - Andó, István AU - Kurucz, Judit Éva TI - Hemolectin expression reveals functional heterogeneity in honey bee (Apis mellifera) hemocytes JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 76 PY - 2017 SP - 403 EP - 411 PG - 9 SN - 0145-305X DO - 10.1016/j.dci.2017.07.013 UR - https://m2.mtmt.hu/api/publication/3249751 ID - 3249751 N1 - Megjegyzés-27090701 Megjegyzés-26822333 OA No LA - English DB - MTMT ER - TY - JOUR AU - Herwald, Heiko AU - Egesten, Arne TI - Bystander Cells Taking Action JF - JOURNAL OF INNATE IMMUNITY J2 - J INNATE IMMUN VL - 9 PY - 2017 IS - 6 SP - 527 EP - 528 PG - 2 SN - 1662-811X DO - 10.1159/000484305 UR - https://m2.mtmt.hu/api/publication/27048635 ID - 27048635 N1 - Export Date: 19 January 2022 LA - English DB - MTMT ER - TY - JOUR AU - Salazar-Jaramillo, L AU - Jalvingh, KM AU - de Haan, A AU - Kraaijeveld, K AU - Buermans, H AU - Wertheim, B TI - Inter- and intra-species variation in genome-wide gene expression of Drosophila in response to parasitoid wasp attack JF - BMC GENOMICS J2 - BMC GENOMICS VL - 18 PY - 2017 IS - 1 SN - 1471-2164 DO - 10.1186/s12864-017-3697-3 UR - https://m2.mtmt.hu/api/publication/26674068 ID - 26674068 N1 - Cited By :17 Export Date: 19 January 2022 CODEN: BGMEE Correspondence Address: Salazar-Jaramillo, L.; The University of Edinburgh, Charlotte Auerbach Road, United Kingdom; email: lauraalazar@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Anderl, I AU - Vesala, L AU - Ihalainen, TO AU - Vanha-Aho, LM AU - Andó, István AU - Ramet, M AU - Hultmark, D TI - Transdifferentiation and Proliferation in Two Distinct Hemocyte Lineages in Drosophila melanogaster Larvae after Wasp Infection. JF - PLOS PATHOGENS J2 - PLOS PATHOG VL - 12 PY - 2016 IS - 7 SP - e1005746 SN - 1553-7366 DO - 10.1371/journal.ppat.1005746 UR - https://m2.mtmt.hu/api/publication/3096913 ID - 3096913 N1 - WoS:hiba:000383366400030 2019-03-03 19:41 első oldal nem egyezik AB - Cellular immune responses require the generation and recruitment of diverse blood cell types that recognize and kill pathogens. In Drosophila melanogaster larvae, immune-inducible lamellocytes participate in recognizing and killing parasitoid wasp eggs. However, the sequence of events required for lamellocyte generation remains controversial. To study the cellular immune system, we developed a flow cytometry approach using in vivo reporters for lamellocytes as well as for plasmatocytes, the main hemocyte type in healthy larvae. We found that two different blood cell lineages, the plasmatocyte and lamellocyte lineages, contribute to the generation of lamellocytes in a demand-adapted hematopoietic process. Plasmatocytes transdifferentiate into lamellocyte-like cells in situ directly on the wasp egg. In parallel, a novel population of infection-induced cells, which we named lamelloblasts, appears in the circulation. Lamelloblasts proliferate vigorously and develop into the major class of circulating lamellocytes. Our data indicate that lamellocyte differentiation upon wasp parasitism is a plastic and dynamic process. Flow cytometry with in vivo hemocyte reporters can be used to study this phenomenon in detail. LA - English DB - MTMT ER - TY - JOUR AU - Chaplinska, M AU - Gerritsma, S AU - Dini-Andreote, F AU - Salles, JF AU - Wertheim, B TI - Bacterial communities differ among drosophila melanogaster populations and affect host resistance against parasitoids JF - PLOS ONE J2 - PLOS ONE VL - 11 PY - 2016 IS - 12 SN - 1932-6203 DO - 10.1371/journal.pone.0167726 UR - https://m2.mtmt.hu/api/publication/26674070 ID - 26674070 N1 - Evolutionary Genetics, Development and Behaviour, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, Netherlands Genomics Research in Ecology and Evolution in Nature, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, Netherlands Cited By :14 Export Date: 19 January 2022 CODEN: POLNC Correspondence Address: Wertheim, B.; Evolutionary Genetics, Netherlands; email: b.wertheim@rug.nl LA - English DB - MTMT ER - TY - JOUR AU - Fors, Lisa AU - Markus, Robert AU - Theopold, Ulrich AU - Ericson, Lars AU - Hamback, Peter A TI - Geographic variation and trade-offs in parasitoid virulence JF - JOURNAL OF ANIMAL ECOLOGY J2 - J ANIM ECOL VL - 85 PY - 2016 IS - 6 SP - 1595 EP - 1604 PG - 10 SN - 0021-8790 DO - 10.1111/1365-2656.12579 UR - https://m2.mtmt.hu/api/publication/26376779 ID - 26376779 N1 - Megjegyzés-26322879 N1 Funding details: IG2011-2042, STINT, Swedish Foundation for International Cooperation in Research and Higher Education N1 Funding text: This work was supported by grants VR-2009-4943 and VR-2012-3578 from the Swedish Research Council Vetenskapsrådet (to PAH), VR-2010-5988 from the Swedish Research Council Vetenskapsrådet (to U.T.) and (IG2011-2042) from the Swedish Foundation for International Cooperation in Research and Higher Education (to U.T.). LA - English DB - MTMT ER - TY - JOUR AU - Herwald, Heiko AU - Egesten, Arne TI - The Origin of a Paradigm JF - JOURNAL OF INNATE IMMUNITY J2 - J INNATE IMMUN VL - 8 PY - 2016 IS - 3 SP - 221 EP - 222 PG - 2 SN - 1662-811X DO - 10.1159/000445282 UR - https://m2.mtmt.hu/api/publication/26015600 ID - 26015600 N1 - Export Date: 19 January 2022 LA - English DB - MTMT ER - TY - JOUR AU - Kari, Beáta AU - Csordás, Gábor AU - Honti, Viktor AU - Cinege, Gyöngyi Ilona AU - Williams, MJ AU - Andó, István AU - Kurucz, Judit Éva TI - The raspberry Gene Is Involved in the Regulation of the Cellular Immune Response in Drosophila melanogaster JF - PLOS ONE J2 - PLOS ONE VL - 11 PY - 2016 IS - 3 PG - 13 SN - 1932-6203 DO - 10.1371/journal.pone.0150910 UR - https://m2.mtmt.hu/api/publication/3045263 ID - 3045263 N1 - Biological Research Centre of Hungarian Academy of Sciences, Immunology Unit, Institute of Genetics, Szeged, Hungary Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden Cited By :6 Export Date: 14 February 2021 CODEN: POLNC AB - Drosophila is an extremely useful model organism for understanding how innate immune mechanisms defend against microbes and parasitoids. Large foreign objects trigger a potent cellular immune response in Drosophila larva. In the case of endoparasitoid wasp eggs, this response includes hemocyte proliferation, lamellocyte differentiation and eventual encapsulation of the egg. The encapsulation reaction involves the attachment and spreading of hemocytes around the egg, which requires cytoskeletal rearrangements, changes in adhesion properties and cell shape, as well as melanization of the capsule. Guanine nucleotide metabolism has an essential role in the regulation of pathways necessary for this encapsulation response. Here, we show that the Drosophila inosine 5'-monophosphate dehydrogenase (IMPDH), encoded by raspberry (ras), is centrally important for a proper cellular immune response against eggs from the parasitoid wasp Leptopilina boulardi. Notably, hemocyte attachment to the egg and subsequent melanization of the capsule are deficient in hypomorphic ras mutant larvae, which results in a compromised cellular immune response and increased survival of the parasitoid. LA - English DB - MTMT ER - TY - JOUR AU - Yu, Ying AU - Cao, Yueqing AU - Xia, Yuxian AU - Liu, Feihong TI - Wright-Giemsa staining to observe phagocytes in Locusta migratoria infected with Metarhizium acridum JF - JOURNAL OF INVERTEBRATE PATHOLOGY J2 - J INVERTEBR PATHOL VL - 139 PY - 2016 SP - 19 EP - 24 PG - 6 SN - 0022-2011 DO - 10.1016/j.jip.2016.06.009 UR - https://m2.mtmt.hu/api/publication/26203047 ID - 26203047 N1 - Cited By :12 Export Date: 19 January 2022 CODEN: JIVPA Correspondence Address: Yu, Y.; College of Pharmacy and Bioengineering, China; email: xxyy@cqut.edu.cn LA - English DB - MTMT ER - TY - JOUR AU - Dudzic, JP AU - Kondo, S AU - Ueda, R AU - Bergman, CM AU - Lemaitre, B TI - Drosophila innate immunity: Regional and functional specialization of prophenoloxidases JF - BMC BIOLOGY J2 - BMC BIOL VL - 13 PY - 2015 IS - 1 SN - 1741-7007 DO - 10.1186/s12915-015-0193-6 UR - https://m2.mtmt.hu/api/publication/25258801 ID - 25258801 N1 - Hiányzó Jelleg: 'JOUR\n\nArticle' LA - English DB - MTMT ER - TY - JOUR AU - Herwald, H AU - Egesten, A TI - Foodies of Innate Immunity JF - JOURNAL OF INNATE IMMUNITY J2 - J INNATE IMMUN VL - 7 PY - 2015 IS - 4 SP - 331 EP - 332 PG - 2 SN - 1662-811X DO - 10.1159/000430800 UR - https://m2.mtmt.hu/api/publication/24982070 ID - 24982070 N1 - Export Date: 19 January 2022 LA - English DB - MTMT ER - TY - JOUR AU - Honti, Viktor AU - Kurucz, Judit Éva AU - Cinege, Gyöngyi Ilona AU - Csordás, Gábor AU - Andó, István TI - Innate immunity JF - ACTA BIOLOGICA SZEGEDIENSIS J2 - ACTA BIOL SZEGED VL - 59 PY - 2015 IS - Suppl. 1 SP - 1 EP - 15 PG - 15 SN - 1588-385X UR - https://m2.mtmt.hu/api/publication/2993019 ID - 2993019 N1 - Export Date: 19 January 2022 CODEN: ABSCC Correspondence Address: Andó, I.; Immunology Unit, Hungary; email: ando@brc.hu LA - English DB - MTMT ER - TY - JOUR AU - Wertheim, B TI - Genomic basis of evolutionary change: Evolving immunity JF - FRONTIERS IN GENETICS J2 - FRONT GENET VL - 6 PY - 2015 IS - JUN SN - 1664-8021 DO - 10.3389/fgene.2015.00222 UR - https://m2.mtmt.hu/api/publication/25139200 ID - 25139200 N1 - Cited By :5 Export Date: 14 June 2022 LA - English DB - MTMT ER -