TY - JOUR AU - Kiss, Dávid Sándor AU - Tóth, István AU - Jócsák, Gergely AU - Bartha, Tibor AU - Frenyó V., László AU - Bárány, Zoltán Balázs AU - Horváth, Tamás AU - Zsarnovszky, Attila TI - Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States JF - REPRODUCTIVE SCIENCES J2 - REPROD SCI VL - 27 PY - 2020 IS - 5 SP - 1197 EP - 1205 PG - 9 SN - 1933-7191 DO - 10.1007/s43032-019-00131-3 UR - https://m2.mtmt.hu/api/publication/31260011 ID - 31260011 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Dávid Sándor AU - Tóth, István AU - Jócsák, Gergely AU - Bárány, Zoltán Balázs AU - Bartha, Tibor AU - Frenyó V., László AU - Horvath, Tamas L. AU - Zsarnovszky, Attila TI - Functional Aspects of Hypothalamic Asymmetry JF - BRAIN SCIENCES J2 - BRAIN SCI VL - 10 PY - 2020 IS - 6 PG - 14 SN - 2076-3425 DO - 10.3390/brainsci10060389 UR - https://m2.mtmt.hu/api/publication/31399182 ID - 31399182 AB - Anatomically, the brain is a symmetric structure. However, growing evidence suggests that certain higher brain functions are regulated by only one of the otherwise duplicated (and symmetric) brain halves. Hemispheric specialization correlates with phylogeny supporting intellectual evolution by providing an ergonomic way of brain processing. The more complex the task, the higher are the benefits of the functional lateralization (all higher functions show some degree of lateralized task sharing). Functional asymmetry has been broadly studied in several brain areas with mirrored halves, such as the telencephalon, hippocampus, etc. Despite its paired structure, the hypothalamus has been generally considered as a functionally unpaired unit, nonetheless the regulation of a vast number of strongly interrelated homeostatic processes are attributed to this relatively small brain region. In this review, we collected all available knowledge supporting the hypothesis that a functional lateralization of the hypothalamus exists. We collected and discussed findings from previous studies that have demonstrated lateralized hypothalamic control of the reproductive functions and energy expenditure. Also, sporadic data claims the existence of a partial functional asymmetry in the regulation of the circadian rhythm, body temperature and circulatory functions. This hitherto neglected data highlights the likely high-level ergonomics provided by such functional asymmetry. LA - English DB - MTMT ER - TY - JOUR AU - Wu, Y. AU - Chen, C. AU - Chen, M. AU - Qian, K. AU - Lv, X. AU - Wang, H. AU - Jiang, L. AU - Yu, L. AU - Zhuo, M. AU - Qiu, S. TI - The anterior insular cortex unilaterally controls feeding in response to aversive visceral stimuli in mice JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 11 PY - 2020 IS - 1 SN - 2041-1723 DO - 10.1038/s41467-020-14281-5 UR - https://m2.mtmt.hu/api/publication/31208464 ID - 31208464 N1 - Center for Neuroscience and Department of Anesthesiology of Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, ON M5S 1A8, Canada Export Date: 6 March 2020 Correspondence Address: Qiu, S.; Center for Neuroscience and Department of Anesthesiology of Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of MedicineChina; email: qiushly@zju.edu.cn Funding details: Fundamental Research Funds for the Central Universities, 2019XZZX001-01-14 Funding details: National Science Fund for Distinguished Young Scholars, LR16C090001 Funding details: B13026 Funding details: China Postdoctoral Science Foundation, PJT-148648, 2018M630665, MOP-124807 Funding details: National Natural Science Foundation of China, NSFC, 81471125, 91732102, 81671049, 31900722 Funding text 1: This work was supported by the National Natural Science Foundation of China (91732102, 81471125, and 81671049 to S.Q., 31900722 to Y.W.), the Zhejiang Science Fund for Distinguished Young Scholars (LR16C090001 to S.Q.), the Fundamental Research Funds for the Central Universities of China (2019XZZX001-01-14 to S.Q.), the Chinese Ministry of Education Project 111 Program (B13026 to S.Q.), and Certificate of China Postdoctoral Science Foundation Grant (2018M630665 to Y.W.). CIHR operating grant (MOP-124807) and project grant (PJT-148648), Azrieli Neu-rodevelopmental Research Program and Brain Canada (M.Z.). We thank Dr. Shumin Duan (Zhejiang University) for providing us with Slc17a6-ires-Cre mice and Dr. Jianhong Luo (Zhejiang University) for providing us with Camk2a-Cre mice. We thank Yudong Zhou (Zhejiang University), Hailan Hu (Zhejiang University), and Tatiana Korotkova (Max Planck Institute for Metabolism Research) for valuable discussion. We also thank the technical support by the Core Facilities, Zhejiang University School of Medicine. Center for Neuroscience and Department of Anesthesiology of Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, ON M5S 1A8, Canada Cited By :1 Export Date: 24 May 2020 Correspondence Address: Qiu, S.; Center for Neuroscience and Department of Anesthesiology of Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of MedicineChina; email: qiushly@zju.edu.cn Chemicals/CAS: calcium calmodulin dependent protein kinase II, 141467-21-2; Aversive Agents; Calcium-Calmodulin-Dependent Protein Kinase Type 2 Funding details: Fundamental Research Funds for the Central Universities, 2019XZZX001-01-14 Funding details: National Science Fund for Distinguished Young Scholars, LR16C090001 Funding details: B13026 Funding details: China Postdoctoral Science Foundation, PJT-148648, 2018M630665, MOP-124807 Funding details: National Natural Science Foundation of China, NSFC, 81471125, 91732102, 81671049, 31900722 Funding text 1: This work was supported by the National Natural Science Foundation of China (91732102, 81471125, and 81671049 to S.Q., 31900722 to Y.W.), the Zhejiang Science Fund for Distinguished Young Scholars (LR16C090001 to S.Q.), the Fundamental Research Funds for the Central Universities of China (2019XZZX001-01-14 to S.Q.), the Chinese Ministry of Education Project 111 Program (B13026 to S.Q.), and Certificate of China Postdoctoral Science Foundation Grant (2018M630665 to Y.W.). CIHR operating grant (MOP-124807) and project grant (PJT-148648), Azrieli Neu-rodevelopmental Research Program and Brain Canada (M.Z.). We thank Dr. Shumin Duan (Zhejiang University) for providing us with Slc17a6-ires-Cre mice and Dr. Jianhong Luo (Zhejiang University) for providing us with Camk2a-Cre mice. We thank Yudong Zhou (Zhejiang University), Hailan Hu (Zhejiang University), and Tatiana Korotkova (Max Planck Institute for Metabolism Research) for valuable discussion. We also thank the technical support by the Core Facilities, Zhejiang University School of Medicine. Center for Neuroscience and Department of Anesthesiology of Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, ON M5S 1A8, Canada Cited By :3 Export Date: 22 March 2021 Correspondence Address: Qiu, S.; Center for Neuroscience and Department of Anesthesiology of Second Affiliated Hospital, China; email: qiushly@zju.edu.cn Chemicals/CAS: calcium calmodulin dependent protein kinase II, 141467-21-2; Aversive Agents; Calcium-Calmodulin-Dependent Protein Kinase Type 2 Funding details: MOP-124807, PJT-148648 Funding details: B13026 Funding details: National Natural Science Foundation of China, NSFC, 31900722 Funding details: China Postdoctoral Science Foundation, 2018M630665 Funding details: Natural Science Foundation of Zhejiang Province, LR16C090001 Funding details: National Natural Science Foundation of China-Yunnan Joint Fund, NSFC-Yunnan Joint Fund, 81471125, 81671049, 91732102 Funding details: Fundamental Research Funds for the Central Universities, 2019XZZX001-01-14 Funding text 1: This work was supported by the National Natural Science Foundation of China (91732102, 81471125, and 81671049 to S.Q., 31900722 to Y.W.), the Zhejiang Science Fund for Distinguished Young Scholars (LR16C090001 to S.Q.), the Fundamental Research Funds for the Central Universities of China (2019XZZX001-01-14 to S.Q.), the Chinese Ministry of Education Project 111 Program (B13026 to S.Q.), and Certificate of China Postdoctoral Science Foundation Grant (2018M630665 to Y.W.). CIHR operating grant (MOP-124807) and project grant (PJT-148648), Azrieli Neu-rodevelopmental Research Program and Brain Canada (M.Z.). We thank Dr. Shumin Duan (Zhejiang University) for providing us with Slc17a6-ires-Cre mice and Dr. Jianhong Luo (Zhejiang University) for providing us with Camk2a-Cre mice. We thank Yudong Zhou (Zhejiang University), Hailan Hu (Zhejiang University), and Tatiana Korotkova (Max Planck Institute for Metabolism Research) for valuable discussion. We also thank the technical support by the Core Facilities, Zhejiang University School of Medicine. AB - Reduced food intake is common to many pathological conditions, such as infection and toxin exposure. However, cortical circuits that mediate feeding responses to these threats are less investigated. The anterior insular cortex (aIC) is a core region that integrates interoceptive states and emotional awareness and consequently guides behavioral responses. Here, we demonstrate that the right-side aIC CamKII+ (aICCamKII) neurons in mice are activated by aversive visceral signals. Hyperactivation of the right-side aICCamKII neurons attenuates food consumption, while inhibition of these neurons increases feeding and reverses aversive stimuli-induced anorexia and weight loss. Similar manipulation at the left-side aIC does not cause significant behavioral changes. Furthermore, virus tracing reveals that aICCamKII neurons project directly to the vGluT2+ neurons in the lateral hypothalamus (LH), and the right-side aICCamKII-to-LH pathway mediates feeding suppression. Our studies uncover a circuit from the cortex to the hypothalamus that senses aversive visceral signals and controls feeding behavior. © 2020, The Author(s). LA - English DB - MTMT ER - TY - JOUR AU - Thomas, K. AU - Beyer, F. AU - Lewe, G. AU - Zhang, R. AU - Schindler, S. AU - Schoenknecht, P. AU - Stumvoll, M. AU - Villringer, A. AU - Witte, A. V. TI - Higher body mass index is linked to altered hypothalamic microstructure JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 9 PY - 2019 PG - 11 SN - 2045-2322 DO - 10.1038/s41598-019-53578-4 UR - https://m2.mtmt.hu/api/publication/31103723 ID - 31103723 AB - Animal studies suggest that obesity-related diets induce structural changes in the hypothalamus, a key brain area involved in energy homeostasis. Whether this translates to humans is however largely unknown. Using a novel multimodal approach with manual segmentation, we here show that a higher body mass index (BMI) selectively predicted higher proton diffusivity within the hypothalamus, indicative of compromised microstructure in the underlying tissue, in a well-characterized population-based cohort (n(1) = 338, 48% females, age 21-78 years, BMI 18-43 kg/m(2)). Results were independent from confounders and confirmed in another independent sample (n(2) = 236). In addition, while hypothalamic volume was not associated with obesity, we identified a sexual dimorphism and larger hypothalamic volumes in the left compared to the right hemisphere. Using two large samples of the general population, we showed that a higher BMI specifically relates to altered microstructure in the hypothalamus, independent from confounders such as age, sex and obesity-associated co-morbidities. This points to persisting microstructural changes in a key regulatory area of energy homeostasis occurring with excessive weight. Our findings may help to better understand the pathomechanisms of obesity and other eating-related disorders. LA - English DB - MTMT ER - TY - JOUR AU - Gaignard, P AU - Fréchou, M AU - Liere, P AU - Thérond, P AU - Schumacher, M AU - Slama, A AU - Guennoun, R TI - Sex differences in brain mitochondrial metabolism: influence of endogenous steroids and stroke JF - JOURNAL OF NEUROENDOCRINOLOGY J2 - J NEUROENDOCRINOL VL - 30 PY - 2018 IS - 2 SN - 0953-8194 DO - 10.1111/jne.12497 UR - https://m2.mtmt.hu/api/publication/27263356 ID - 27263356 N1 - U1195 Inserm and University Paris-Sud and University Paris-Saclay, Kremlin-Bicêtre, France Biochemistry Laboratory, Bicêtre Hospital, Assistance-Publique Hôpitaux de Paris, Kremlin-Bicêtre, France Cited By :10 Export Date: 11 July 2019 CODEN: JOUNE Correspondence Address: Guennoun, R.; U1195 Inserm and University Paris-Sud and University Paris-SaclayFrance; email: rachida.guennoun@inserm.fr Chemicals/CAS: estradiol, 50-28-2; progesterone, 57-83-0 LA - English DB - MTMT ER - TY - JOUR AU - Jócsák, Gergely AU - Kiss, Dávid Sándor AU - Tóth, István AU - Barany, Z AU - Zsarnovszky, Attila AU - Frenyó V., László TI - A zearalenon, mint mikotoxin káros hatásai az emlős szervezetben: az utóbbi évtizedek eredményeinek rövid áttekintése JF - MAGYAR ÁLLATORVOSOK LAPJA J2 - MAGY ALLATORVOSOK VL - 139 PY - 2017 IS - 1 SP - 55 EP - 64 PG - 10 SN - 0025-004X UR - https://m2.mtmt.hu/api/publication/3170837 ID - 3170837 AB - The authors present their study on the summarized effects of zearalenone (ZEA) on the mammalian neuroendocrine system. Oestrogen and oestrogen receptors play a key role in mammalian physiology. Endocrine disruptors, such as ZEA have the ability to interfere with hormonal regulatory pathways due to their oestrogenlike molecular structure. The aim of the present review is to discuss the best known effects of ZEA poisoning. ZEA is a well-known mycotoxin, usually found in contaminated unprocessed maize and other cereal kernel. The contamination begins at the growing area, however it can also spread during improper storage, causing a contamination in the feed. This is still a serious problem in animal husbandry and in the industrial production of meat. After ingestion, the toxin can easily get into the body. ZEA can directly induce apoptosis, thus causing cell loss in specific organs (mostly in the liver and the immune system) resulting in a decreased, weakened function. In addition to the cellular effects, ZEA also acts as endocrine disruptor, it alters the physiological neuroendocrine regulation, thus disrupting the physiological action of the organs requiring oestrogen modulation. ZEA has a serious impact on the production of the cellular components of the blood; the quality, and cellular quantity of the immune response; the homeostasis and the functions during detoxification of the liver and kidneys; the neuroendocrine organ functions (disrupting the regulative characteristics of specific parts of the hormonal milieu in the animals) and even on the central nervous system. Most importantly ZEA can interfere with the reproductive physiology of animals (due to the disruption on the neuroendocrine regulation), thus lowering the possible productivity of the livestock, causing major economic losses. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tóth, István AU - Kiss, Dávid Sándor AU - Frenyó V., László AU - Zsarnovszky, Attila TI - A reprodukció és táplálékfelvétel centrális irányítása: a hipotalamusz aszimmetrikus működése. Central regulation of reproduction and food-intake: functional asymmetry in the hypothalamus TS - Central regulation of reproduction and food-intake: functional asymmetry in the hypothalamus JF - MAGYAR ÁLLATORVOSOK LAPJA J2 - MAGY ALLATORVOSOK VL - 139 PY - 2017 IS - 4 SP - 235 EP - 245 PG - 10 SN - 0025-004X UR - https://m2.mtmt.hu/api/publication/3285991 ID - 3285991 AB - Background: The hypothalamus is the highest center and the main crossroad of numerous homeostatic regulatory pathways including reproductive and hunger-satiety cycles Histologically, the left and right hypothalamic sides are sym-metrical still ,it has been considered as an unpaired midline structure in which the indentical circuits of the two sides regulate exactly the same biological functions, Hoeever .it has been known for higher, morphologically aslo symmetric brain areas that usually the left and right sides and have distinct physiological roles providing a solution for the "ergonomic" use of brain resources Objective: The main goal of this article is to shortly sum up our present knowledge on the hypothalamic funtions related to the regulation of food -intake and reproduction, Furthermore ,the authors aslo review the asymmetric function of the central nervous system in which a special focus is put on the hyporthalamus Discussion and conclusion: Function of the central nervous system from the spinal cord to the cerebral cartex are more specfied to certain functions, and function show lateralization to different degrees. This evolutionary process of lateralization would provide a much more effective use brain resources Based on the presented data in this article, we can state that the hypothalamus, similar to the cortex, shows asymmetric function and it seems to be rightful to re-name the hypothalamic sides to hypothalamic hemispheres. This novel aspect on the hypothalamic hemispheres change our current view on the regulation of female reproduction and food-intake and provides new perspectives for the bettar understanding of these hypotalamus -driven physiological processes. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tóth, István AU - Kiss, Dávid Sándor AU - Jócsák, Gergely AU - Somogyi, Virág AU - Toronyi, Éva AU - Bartha, Tibor AU - Frenyó V., László AU - Horváth, Tamás AU - Zsarnovszky, Attila TI - Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats. JF - PLOS ONE J2 - PLOS ONE VL - 10 PY - 2015 IS - 9 PG - 11 SN - 1932-6203 DO - 10.1371/journal.pone.0137462 UR - https://m2.mtmt.hu/api/publication/2940248 ID - 2940248 AB - Hypothalamus is the highest center and the main crossroad of numerous homeostatic regulatory pathways including reproduction and energy metabolism. Previous reports indicate that some of these functions may be driven by the synchronized but distinct functioning of the left and right hypothalamic sides. However, the nature of interplay between the hemispheres with regard to distinct hypothalamic functions is still unclear. Here we investigated the metabolic asymmetry between the left and right hypothalamic sides of ovariectomized female rats by measuring mitochondrial respiration rates, a parameter that reflects the intensity of cell and tissue metabolism. Ovariectomized (saline injected) and ovariectomized+estrogen injected animals were fed ad libitum or fasted to determine 1) the contribution of estrogen to metabolic asymmetry of hypothalamus; and 2) whether the hypothalamic asymmetry is modulated by the satiety state. Results show that estrogen-priming significantly increased both the proportion of animals with detected hypothalamic lateralization and the degree of metabolic difference between the hypothalamic sides causing a right-sided dominance during state 3 mitochondrial respiration (St3) in ad libitum fed animals. After 24 hours of fasting, lateralization in St3 values was clearly maintained; however, instead of the observed right-sided dominance that was detected in ad libitum fed animals here appeared in form of either right- or left-sidedness. In conclusion, our results revealed estrogen- and satiety state-dependent metabolic differences between the two hypothalamic hemispheres in female rats showing that the hypothalamic hemispheres drive the reproductive and satiety state related functions in an asymmetric manner. LA - English DB - MTMT ER -