@article{MTMT:31260011, title = {Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States}, url = {https://m2.mtmt.hu/api/publication/31260011}, author = {Kiss, Dávid Sándor and Tóth, István and Jócsák, Gergely and Bartha, Tibor and Frenyó V., László and Bárány, Zoltán Balázs and Horváth, Tamás and Zsarnovszky, Attila}, doi = {10.1007/s43032-019-00131-3}, journal-iso = {REPROD SCI}, journal = {REPRODUCTIVE SCIENCES}, volume = {27}, unique-id = {31260011}, issn = {1933-7191}, year = {2020}, eissn = {1933-7205}, pages = {1197-1205}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @article{MTMT:31399182, title = {Functional Aspects of Hypothalamic Asymmetry}, url = {https://m2.mtmt.hu/api/publication/31399182}, author = {Kiss, Dávid Sándor and Tóth, István and Jócsák, Gergely and Bárány, Zoltán Balázs and Bartha, Tibor and Frenyó V., László and Horvath, Tamas L. and Zsarnovszky, Attila}, doi = {10.3390/brainsci10060389}, journal-iso = {BRAIN SCI}, journal = {BRAIN SCIENCES}, volume = {10}, unique-id = {31399182}, abstract = {Anatomically, the brain is a symmetric structure. However, growing evidence suggests that certain higher brain functions are regulated by only one of the otherwise duplicated (and symmetric) brain halves. Hemispheric specialization correlates with phylogeny supporting intellectual evolution by providing an ergonomic way of brain processing. The more complex the task, the higher are the benefits of the functional lateralization (all higher functions show some degree of lateralized task sharing). Functional asymmetry has been broadly studied in several brain areas with mirrored halves, such as the telencephalon, hippocampus, etc. Despite its paired structure, the hypothalamus has been generally considered as a functionally unpaired unit, nonetheless the regulation of a vast number of strongly interrelated homeostatic processes are attributed to this relatively small brain region. In this review, we collected all available knowledge supporting the hypothesis that a functional lateralization of the hypothalamus exists. We collected and discussed findings from previous studies that have demonstrated lateralized hypothalamic control of the reproductive functions and energy expenditure. Also, sporadic data claims the existence of a partial functional asymmetry in the regulation of the circadian rhythm, body temperature and circulatory functions. This hitherto neglected data highlights the likely high-level ergonomics provided by such functional asymmetry.}, year = {2020}, eissn = {2076-3425}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @article{MTMT:31208464, title = {The anterior insular cortex unilaterally controls feeding in response to aversive visceral stimuli in mice}, url = {https://m2.mtmt.hu/api/publication/31208464}, author = {Wu, Y. and Chen, C. and Chen, M. and Qian, K. and Lv, X. and Wang, H. and Jiang, L. and Yu, L. and Zhuo, M. and Qiu, S.}, doi = {10.1038/s41467-020-14281-5}, journal-iso = {NAT COMMUN}, journal = {NATURE COMMUNICATIONS}, volume = {11}, unique-id = {31208464}, issn = {2041-1723}, abstract = {Reduced food intake is common to many pathological conditions, such as infection and toxin exposure. However, cortical circuits that mediate feeding responses to these threats are less investigated. The anterior insular cortex (aIC) is a core region that integrates interoceptive states and emotional awareness and consequently guides behavioral responses. Here, we demonstrate that the right-side aIC CamKII+ (aICCamKII) neurons in mice are activated by aversive visceral signals. Hyperactivation of the right-side aICCamKII neurons attenuates food consumption, while inhibition of these neurons increases feeding and reverses aversive stimuli-induced anorexia and weight loss. Similar manipulation at the left-side aIC does not cause significant behavioral changes. Furthermore, virus tracing reveals that aICCamKII neurons project directly to the vGluT2+ neurons in the lateral hypothalamus (LH), and the right-side aICCamKII-to-LH pathway mediates feeding suppression. Our studies uncover a circuit from the cortex to the hypothalamus that senses aversive visceral signals and controls feeding behavior. © 2020, The Author(s).}, keywords = {INHIBITION; VIRUS; pathology; food intake; Mus; behavioral response; rodent; TOXIN; food consumption; cell component; Biostimulation}, year = {2020}, eissn = {2041-1723} } @article{MTMT:31103723, title = {Higher body mass index is linked to altered hypothalamic microstructure}, url = {https://m2.mtmt.hu/api/publication/31103723}, author = {Thomas, K. and Beyer, F. and Lewe, G. and Zhang, R. and Schindler, S. and Schoenknecht, P. and Stumvoll, M. and Villringer, A. and Witte, A. V.}, doi = {10.1038/s41598-019-53578-4}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {9}, unique-id = {31103723}, issn = {2045-2322}, abstract = {Animal studies suggest that obesity-related diets induce structural changes in the hypothalamus, a key brain area involved in energy homeostasis. Whether this translates to humans is however largely unknown. Using a novel multimodal approach with manual segmentation, we here show that a higher body mass index (BMI) selectively predicted higher proton diffusivity within the hypothalamus, indicative of compromised microstructure in the underlying tissue, in a well-characterized population-based cohort (n(1) = 338, 48% females, age 21-78 years, BMI 18-43 kg/m(2)). Results were independent from confounders and confirmed in another independent sample (n(2) = 236). In addition, while hypothalamic volume was not associated with obesity, we identified a sexual dimorphism and larger hypothalamic volumes in the left compared to the right hemisphere. Using two large samples of the general population, we showed that a higher BMI specifically relates to altered microstructure in the hypothalamus, independent from confounders such as age, sex and obesity-associated co-morbidities. This points to persisting microstructural changes in a key regulatory area of energy homeostasis occurring with excessive weight. Our findings may help to better understand the pathomechanisms of obesity and other eating-related disorders.}, year = {2019}, eissn = {2045-2322} } @article{MTMT:27263356, title = {Sex differences in brain mitochondrial metabolism: influence of endogenous steroids and stroke}, url = {https://m2.mtmt.hu/api/publication/27263356}, author = {Gaignard, P and Fréchou, M and Liere, P and Thérond, P and Schumacher, M and Slama, A and Guennoun, R}, doi = {10.1111/jne.12497}, journal-iso = {J NEUROENDOCRINOL}, journal = {JOURNAL OF NEUROENDOCRINOLOGY}, volume = {30}, unique-id = {27263356}, issn = {0953-8194}, year = {2018}, eissn = {1365-2826} } @article{MTMT:3170837, title = {A zearalenon, mint mikotoxin káros hatásai az emlős szervezetben: az utóbbi évtizedek eredményeinek rövid áttekintése}, url = {https://m2.mtmt.hu/api/publication/3170837}, author = {Jócsák, Gergely and Kiss, Dávid Sándor and Tóth, István and Barany, Z and Zsarnovszky, Attila and Frenyó V., László}, journal-iso = {MAGY ALLATORVOSOK}, journal = {MAGYAR ÁLLATORVOSOK LAPJA}, volume = {139}, unique-id = {3170837}, issn = {0025-004X}, abstract = {The authors present their study on the summarized effects of zearalenone (ZEA) on the mammalian neuroendocrine system. Oestrogen and oestrogen receptors play a key role in mammalian physiology. Endocrine disruptors, such as ZEA have the ability to interfere with hormonal regulatory pathways due to their oestrogenlike molecular structure. The aim of the present review is to discuss the best known effects of ZEA poisoning. ZEA is a well-known mycotoxin, usually found in contaminated unprocessed maize and other cereal kernel. The contamination begins at the growing area, however it can also spread during improper storage, causing a contamination in the feed. This is still a serious problem in animal husbandry and in the industrial production of meat. After ingestion, the toxin can easily get into the body. ZEA can directly induce apoptosis, thus causing cell loss in specific organs (mostly in the liver and the immune system) resulting in a decreased, weakened function. In addition to the cellular effects, ZEA also acts as endocrine disruptor, it alters the physiological neuroendocrine regulation, thus disrupting the physiological action of the organs requiring oestrogen modulation. ZEA has a serious impact on the production of the cellular components of the blood; the quality, and cellular quantity of the immune response; the homeostasis and the functions during detoxification of the liver and kidneys; the neuroendocrine organ functions (disrupting the regulative characteristics of specific parts of the hormonal milieu in the animals) and even on the central nervous system. Most importantly ZEA can interfere with the reproductive physiology of animals (due to the disruption on the neuroendocrine regulation), thus lowering the possible productivity of the livestock, causing major economic losses.}, year = {2017}, pages = {55-64}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @article{MTMT:3285991, title = {A reprodukció és táplálékfelvétel centrális irányítása: a hipotalamusz aszimmetrikus működése. Central regulation of reproduction and food-intake: functional asymmetry in the hypothalamus}, url = {https://m2.mtmt.hu/api/publication/3285991}, author = {Tóth, István and Kiss, Dávid Sándor and Frenyó V., László and Zsarnovszky, Attila}, journal-iso = {MAGY ALLATORVOSOK}, journal = {MAGYAR ÁLLATORVOSOK LAPJA}, volume = {139}, unique-id = {3285991}, issn = {0025-004X}, abstract = {Background: The hypothalamus is the highest center and the main crossroad of numerous homeostatic regulatory pathways including reproductive and hunger-satiety cycles Histologically, the left and right hypothalamic sides are sym-metrical still ,it has been considered as an unpaired midline structure in which the indentical circuits of the two sides regulate exactly the same biological functions, Hoeever .it has been known for higher, morphologically aslo symmetric brain areas that usually the left and right sides and have distinct physiological roles providing a solution for the "ergonomic" use of brain resources Objective: The main goal of this article is to shortly sum up our present knowledge on the hypothalamic funtions related to the regulation of food -intake and reproduction, Furthermore ,the authors aslo review the asymmetric function of the central nervous system in which a special focus is put on the hyporthalamus Discussion and conclusion: Function of the central nervous system from the spinal cord to the cerebral cartex are more specfied to certain functions, and function show lateralization to different degrees. This evolutionary process of lateralization would provide a much more effective use brain resources Based on the presented data in this article, we can state that the hypothalamus, similar to the cortex, shows asymmetric function and it seems to be rightful to re-name the hypothalamic sides to hypothalamic hemispheres. This novel aspect on the hypothalamic hemispheres change our current view on the regulation of female reproduction and food-intake and provides new perspectives for the bettar understanding of these hypotalamus -driven physiological processes.}, year = {2017}, pages = {235-245}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @article{MTMT:2940248, title = {Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats.}, url = {https://m2.mtmt.hu/api/publication/2940248}, author = {Tóth, István and Kiss, Dávid Sándor and Jócsák, Gergely and Somogyi, Virág and Toronyi, Éva and Bartha, Tibor and Frenyó V., László and Horváth, Tamás and Zsarnovszky, Attila}, doi = {10.1371/journal.pone.0137462}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {10}, unique-id = {2940248}, issn = {1932-6203}, abstract = {Hypothalamus is the highest center and the main crossroad of numerous homeostatic regulatory pathways including reproduction and energy metabolism. Previous reports indicate that some of these functions may be driven by the synchronized but distinct functioning of the left and right hypothalamic sides. However, the nature of interplay between the hemispheres with regard to distinct hypothalamic functions is still unclear. Here we investigated the metabolic asymmetry between the left and right hypothalamic sides of ovariectomized female rats by measuring mitochondrial respiration rates, a parameter that reflects the intensity of cell and tissue metabolism. Ovariectomized (saline injected) and ovariectomized+estrogen injected animals were fed ad libitum or fasted to determine 1) the contribution of estrogen to metabolic asymmetry of hypothalamus; and 2) whether the hypothalamic asymmetry is modulated by the satiety state. Results show that estrogen-priming significantly increased both the proportion of animals with detected hypothalamic lateralization and the degree of metabolic difference between the hypothalamic sides causing a right-sided dominance during state 3 mitochondrial respiration (St3) in ad libitum fed animals. After 24 hours of fasting, lateralization in St3 values was clearly maintained; however, instead of the observed right-sided dominance that was detected in ad libitum fed animals here appeared in form of either right- or left-sidedness. In conclusion, our results revealed estrogen- and satiety state-dependent metabolic differences between the two hypothalamic hemispheres in female rats showing that the hypothalamic hemispheres drive the reproductive and satiety state related functions in an asymmetric manner.}, year = {2015}, eissn = {1932-6203}, orcid-numbers = {Tóth, István/0000-0002-0168-4753; Toronyi, Éva/0000-0002-6284-6373} }