TY - JOUR AU - Fu, Huiling AU - Peng, Mijun AU - Tang, Qiuwen AU - Liang, Haojun AU - Liang, Yanli AU - Fang, Jiali AU - Wang, Xuesong TI - Comprehensive Assessment of the Safety of Eucommia ulmoides Leaf Extract for Consumption as a Traditional Chinese Health Food JF - JOURNAL OF RENEWABLE MATERIALS J2 - J RENEW MATERIALS PY - 2023 PG - 24 SN - 2164-6325 DO - 10.32604/jrm.2023.026689 UR - https://m2.mtmt.hu/api/publication/33893472 ID - 33893472 AB - To ensure the export quality of Eucommia ulmoides leaf extract (ELE) and facilitate E. ulmoides leaf inclusion in the directory of traditional Chinese health foods, an overall safety assessment of ELE was performed, including genotoxicity and long-term toxicity, according to the national food safety standards of China. No variations in the reverse mutation number of the nominal bacterial strains were observed under ELE treatment in comparison with the solvent control. Additionally, the micronucleus rates of in vivo mammalian erythrocytes and in vitro mammalian cells under ELE treatment were equivalent to or significantly lower than those of the solvent control. The fold change in the trifluorothymidine resistance mutation frequency of the thymidine kinase gene under ELE treatment was less than three times in comparison with the solvent control, suggesting that ELE did not cause genotoxicity. Moreover, animal experiments showed that the growth performance of rats under ELE treatment was enhanced because the body weights of rats increased. No oxidative injury or inflammatory responses were induced and no histopathological lesions of tissues were detected under ELE treatment. In addition, plasma triglycerides and low-density lipoprotein cholesterol levels significantly decreased, and plasma high-density lipoprotein cholesterol levels significantly increased with ELE treatment, suggesting that ELE was health-promoting. Furthermore, moderate to excellent antimicrobial activities, a favorable anticancer capacity, and superior antioxidant abilities of ELE were found, implying ELE possesses good bioactivities. Therefore, we affirmed ELE is safe to consume as a traditional Chinese health food. LA - English DB - MTMT ER - TY - JOUR AU - Upadyshev, Mikhail AU - Ivanova, Bojidarka AU - Motyleva, Svetlana TI - Mass Spectrometric Identification of Metabolites after Magnetic-Pulse Treatment of Infected Pyrus communis L. Microplants JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 23 PG - 30 SN - 1661-6596 DO - 10.3390/ijms242316776 UR - https://m2.mtmt.hu/api/publication/34610196 ID - 34610196 AB - The major goal of this study is to create a venue for further work on the effect of pulsed magnetic fields on plant metabolism. It deals with metabolite synthesis in the aforementioned conditions in microplants of Pyrus communis L. So far, there have been glimpses into the governing factors of plant biochemistry in vivo, and low-frequency pulsed magnestatic fields have been shown to induce additional electric currents in plant tissues, thus perturbing the value of cell membrane potential and causing the biosynthesis of new metabolites. In this study, sixty-seven metabolites synthesized in microplants within 3-72 h after treatment were identified and annotated. In total, thirty-one metabolites were produced. Magnetic-pulse treatment caused an 8.75-fold increase in the concentration of chlorogenic acid (RT = 8.33 +/- 0.01(97) min) in tissues and the perturbation of phenolic composition. Aucubin, which has antiviral and antistress biological activity, was identified as well. This study sheds light on the effect of magnetic fields on the biochemistry of low-molecular-weight metabolites of pear plants in vitro, thus providing in-depth metabolite analysis under optimized synthetic conditions. This study utilized high-resolution gas chromatography-mass spectrometry, metabolomics methods, stochastic dynamics mass spectrometry, quantum chemistry, and chemometrics, respectively. Stochastic dynamics uses the relationships between measurands and molecular structures of silylated carbohydrates, showing virtually identical mass spectra and comparable chemometrics parameters. LA - English DB - MTMT ER - TY - JOUR AU - Aziz, Farina AU - Al Noman, Md Abdullah AU - Hasan, Choudhury Mahmood AU - Ahsan, Monira TI - IRIDOIDS AND CYTOTOXIC TERPENES FROM Lindenbergia indica JF - CHEMISTRY OF NATURAL COMPOUNDS J2 - CHEM NAT COMPD VL - 58 PY - 2022 IS - 3 SP - 450 EP - 454 PG - 5 SN - 0009-3130 DO - 10.1007/s10600-022-03706-w UR - https://m2.mtmt.hu/api/publication/33006867 ID - 33006867 AB - A new iridoid aglycone, I-acetylscyphiphin B-2 along with two known iridoid aglycones and three triterpenes, was isolated from the whole plant of Lindenbergia indica. The known compounds were identified as scyphiphin B-1, 1 beta,6 beta,7 alpha,8 alpha,10-pentahydroxy-cis-2-oxabicyclo[4.3.0]nonane, salacianol, 20-hydroxylupan-3-one, and acetylursolic acid, all of which constitute the first record of such compounds from this species. The isolation of iridoids from this plant supports the taxonomic position within the tribe Gratioleae. Salacianol and acetylursolic acid exhibited moderate cytotoxic activity on all tested stomach cancer cell lines. LA - English DB - MTMT ER - TY - JOUR AU - Wang, Xue-song AU - Peng, Mi-jun AU - He, Chun-tao TI - The antihypertensive effects of Eucommia ulmoides leaf water/ethanol extracts are chlorogenic acid dependent JF - JOURNAL OF FUNCTIONAL FOODS J2 - J FUNCT FOODS VL - 94 PY - 2022 PG - 10 SN - 1756-4646 DO - 10.1016/j.jff.2022.105129 UR - https://m2.mtmt.hu/api/publication/33006866 ID - 33006866 AB - The antihypertensive effects of Eucommia ulmoides were determined between normal rats and spontaneously hypertensive rats daily gavaged with leaf extracts, bark extract, chlorogenic acid (CGA), and captopril. Significant composition difference between leaf and bark extracts were noted since CGA was only detected in leaf extract. The overall antihypertensive effects ranked as captopril > CGA > leaf extracts > bark extract, indicating the antihypertensive effect of E. ulmoides extract was CGA-dependent. The hypertension related targets of CGA were screened out and ten KEGG pathways of these targets were significantly enriched, indicating CGA took function in antihypertension via multiple biological processes. Molecular docking revealed CGA bound more tightly to hypertension related targets than captopril, indicating CGA positively participated in antihypertension. However, drug-likeness evaluation displayed the bioavailability of CGA was 5 times lower than captopril, which was consistent with dosage difference in animal experimental. Hence, the antihypertensive effect of CGA was bioavailability limited. LA - English DB - MTMT ER - TY - JOUR AU - Wang, Xuesong AU - Wang, Zhihong AU - Yang, Qiuling AU - Peng, Sheng AU - Peng, Mijun TI - Determining the in vitro Anti-Aging Effect of the Characteristic Components from Eucommia ulmoides JF - JOURNAL OF RENEWABLE MATERIALS J2 - J RENEW MATERIALS PY - 2022 PG - 15 SN - 2164-6325 DO - 10.32604/jrm.2022.020204 UR - https://m2.mtmt.hu/api/publication/33006868 ID - 33006868 AB - To evaluate the potential anti-aging ability of Eucommia ulmoides, four characteristic components (chlorogenic acid, geniposidic acid, aucubin, quercetin) were selected to assess their effects on H2O2-induced oxidative damage model of human umbilical vein endothelial cell (HUVEC). Oxidative damage indexes, inflammatory factors, cell cycle, cell apoptosis, cell senescence, and their related proteins were analyzed by methyl thiazolyl tetrazolium (MTT) assay, enzyme-linked immunosorbent assay (ELISA), propidium iodide (PI) staining, annexin V-FITC/ PI double staining, SA beta-galactosidase staining, and western blotting (WB). The results showed that H2O2-induced cell growth inhibition rate decreased as supplementation with characteristic components when compared to H2O2 group. Meanwhile, the contents of antioxidant indexes (reactive oxygen species, lactate dehydrogenase, molondialdehyde, superoxide dismutase, glutathione), inflammatory factors (nuclear factor kappa-B, intercellular cell adhesion molecule-1, vascular cell adhesion protein 1), and functional factors (NO, Endothelin-1) in charac-teristic components treated groups improved if comparison with H2O2 group, suggesting the characteristic com-ponents of E. ulmoides could alleviate H2O2-induced oxidative damage. Moreover, cell cycle, cell apoptosis, cell senescence, and their related proteins under characteristic components treatment exhibited a better effect than under H2O2 treatment, implying the characteristic components could participate in anti-aging via multiple path-ways. These results manifested that the characteristic components of E. ulmoides posses the capacity of anti-aging, which provided a basis for investigating the anti-aging ability of E. ulmoides itself. LA - English DB - MTMT ER - TY - JOUR AU - Karadağ, Ayşe Esra AU - Tosun, Fatma TI - In vitro antimicrobial and antioxidant activity evaluation of melampyrum arvense l. var. elatius boiss. and sedum spurium m. bieb. extracts JF - Acta Pharmaceutica Sciencia J2 - Acta Pharmaceutica Sciencia VL - 57 PY - 2019 IS - 2 SP - 193 EP - 201 PG - 9 SN - 2636-8552 DO - 10.23893/1307-2080.APS.05712 UR - https://m2.mtmt.hu/api/publication/30969586 ID - 30969586 LA - English DB - MTMT ER - TY - JOUR AU - Háznagyné Radnai, Erzsébet AU - Fási, Laura AU - Wéber, Edit AU - Pinke, Gyula AU - Király, Botond Gergely AU - Sztojkov-Ivanov, Anita AU - Gáspár, Róbert AU - Hohmann, Judit TI - Anti-inflammatory Activity of Melampyrum barbatum and Isolation of Iridoid and Flavonoid Compounds JF - NATURAL PRODUCT COMMUNICATIONS J2 - NAT PROD COMMUN VL - 13 PY - 2018 IS - 3 SP - 235 EP - 236 PG - 2 SN - 1934-578X DO - 10.1177/1934578x1801300301 UR - https://m2.mtmt.hu/api/publication/3347203 ID - 3347203 AB - Melampyrum barbatum Waldst. & Kit. ex Willd. (Scrophulariaceae) has been used in traditional medicine for the treatment of rheumatic complaints and different skin diseases. In the course of our study the anti-inflammatory activity of the aerial parts of M barbatum was evaluated. A MeOH extract was prepared and consecutively partitioned with CHCl3, EtOAc and n-BuOH. The fractions were assayed in in vivo carrageenan-induced rat paw oedema model. The intraperitoneally administered n-BuOH phase exerted marked inhibitory effect (33.6 %, p < 0.01). Multistep chromatographic separation afforded mussaenoside and aucubine from n-BuOH fraction. Moreover, 8-epiloganin, loganic acid and mussaenoside were obtained from EtOAc fraction and apigenin, luteolin, benzoic acid and galactitol from CHCl3 fraction. These data validate the ethnomedicinal use of M barbatum for the treatment of inflammatory diseases and reveal that iridoids and flavonoids could be responsible for the anti-inflammatory effect of this species. LA - English DB - MTMT ER - TY - JOUR AU - Kim, MI AU - Kim, CY TI - Four New Acylated Iridoid Glycosides from the Aerial Part of Veronicastrum sibiricum and Their Antioxidant Response Element-Inducing Activity JF - CHEMISTRY & BIODIVERSITY J2 - CHEM BIODIVERS VL - 15 PY - 2018 IS - 1 SN - 1612-1872 DO - 10.1002/cbdv.201700447 UR - https://m2.mtmt.hu/api/publication/27166178 ID - 27166178 LA - English DB - MTMT ER - TY - JOUR AU - CHEN, Ya-jun WANG Zhi-bin YU Ying GAO Yan YANG Chun-juan BI Xue-yan KUANG Hai-xue TI - Structural identification of iridoids from leaves of Hydrangea macrophylla JF - CHINESE TRADITIONAL AND HERBAL DRUGS J2 - CHINESE TRADITIONAL AND HERBAL DRUGS VL - 48 PY - 2017 IS - 2 SP - 232 EP - 235 PG - 4 SN - 0253-2670 DO - 10.7501/j.issn.0253-2670.2017.02.002 UR - https://m2.mtmt.hu/api/publication/26647816 ID - 26647816 LA - English DB - MTMT ER -