@article{MTMT:33893472,
	title = {Comprehensive Assessment of the Safety of Eucommia ulmoides Leaf Extract for Consumption as a Traditional Chinese Health Food},
	url = {https://m2.mtmt.hu/api/publication/33893472},
	author = {Fu, Huiling and Peng, Mijun and Tang, Qiuwen and Liang, Haojun and Liang, Yanli and Fang, Jiali and Wang, Xuesong},
	doi = {10.32604/jrm.2023.026689},
	journal-iso = {J RENEW MATERIALS},
	journal = {JOURNAL OF RENEWABLE MATERIALS},
	unique-id = {33893472},
	issn = {2164-6325},
	abstract = {To ensure the export quality of Eucommia ulmoides leaf extract (ELE) and facilitate E. ulmoides leaf inclusion in the directory of traditional Chinese health foods, an overall safety assessment of ELE was performed, including genotoxicity and long-term toxicity, according to the national food safety standards of China. No variations in the reverse mutation number of the nominal bacterial strains were observed under ELE treatment in comparison with the solvent control. Additionally, the micronucleus rates of in vivo mammalian erythrocytes and in vitro mammalian cells under ELE treatment were equivalent to or significantly lower than those of the solvent control. The fold change in the trifluorothymidine resistance mutation frequency of the thymidine kinase gene under ELE treatment was less than three times in comparison with the solvent control, suggesting that ELE did not cause genotoxicity. Moreover, animal experiments showed that the growth performance of rats under ELE treatment was enhanced because the body weights of rats increased. No oxidative injury or inflammatory responses were induced and no histopathological lesions of tissues were detected under ELE treatment. In addition, plasma triglycerides and low-density lipoprotein cholesterol levels significantly decreased, and plasma high-density lipoprotein cholesterol levels significantly increased with ELE treatment, suggesting that ELE was health-promoting. Furthermore, moderate to excellent antimicrobial activities, a favorable anticancer capacity, and superior antioxidant abilities of ELE were found, implying ELE possesses good bioactivities. Therefore, we affirmed ELE is safe to consume as a traditional Chinese health food.},
	keywords = {genotoxicity; BIOACTIVITY; Growth performance; Long-term toxicity; Eucommia ulmoides leaf extract},
	year = {2023},
	eissn = {2164-6341}
}

@article{MTMT:34610196,
	title = {Mass Spectrometric Identification of Metabolites after Magnetic-Pulse Treatment of Infected Pyrus communis L. Microplants},
	url = {https://m2.mtmt.hu/api/publication/34610196},
	author = {Upadyshev, Mikhail and Ivanova, Bojidarka and Motyleva, Svetlana},
	doi = {10.3390/ijms242316776},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34610196},
	issn = {1661-6596},
	abstract = {The major goal of this study is to create a venue for further work on the effect of pulsed magnetic fields on plant metabolism. It deals with metabolite synthesis in the aforementioned conditions in microplants of Pyrus communis L. So far, there have been glimpses into the governing factors of plant biochemistry in vivo, and low-frequency pulsed magnestatic fields have been shown to induce additional electric currents in plant tissues, thus perturbing the value of cell membrane potential and causing the biosynthesis of new metabolites. In this study, sixty-seven metabolites synthesized in microplants within 3-72 h after treatment were identified and annotated. In total, thirty-one metabolites were produced. Magnetic-pulse treatment caused an 8.75-fold increase in the concentration of chlorogenic acid (RT = 8.33 +/- 0.01(97) min) in tissues and the perturbation of phenolic composition. Aucubin, which has antiviral and antistress biological activity, was identified as well. This study sheds light on the effect of magnetic fields on the biochemistry of low-molecular-weight metabolites of pear plants in vitro, thus providing in-depth metabolite analysis under optimized synthetic conditions. This study utilized high-resolution gas chromatography-mass spectrometry, metabolomics methods, stochastic dynamics mass spectrometry, quantum chemistry, and chemometrics, respectively. Stochastic dynamics uses the relationships between measurands and molecular structures of silylated carbohydrates, showing virtually identical mass spectra and comparable chemometrics parameters.},
	keywords = {CHROMATOGRAPHY; Structural analysis; Pyrus communis L.; mass spectrometric metabolomics; magnetic-pulse irradiation},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Ivanova, Bojidarka/0000-0002-5788-4404}
}

@article{MTMT:33006867,
	title = {IRIDOIDS AND CYTOTOXIC TERPENES FROM Lindenbergia indica},
	url = {https://m2.mtmt.hu/api/publication/33006867},
	author = {Aziz, Farina and Al Noman, Md Abdullah and Hasan, Choudhury Mahmood and Ahsan, Monira},
	doi = {10.1007/s10600-022-03706-w},
	journal-iso = {CHEM NAT COMPD},
	journal = {CHEMISTRY OF NATURAL COMPOUNDS},
	volume = {58},
	unique-id = {33006867},
	issn = {0009-3130},
	abstract = {A new iridoid aglycone, I-acetylscyphiphin B-2 along with two known iridoid aglycones and three triterpenes, was isolated from the whole plant of Lindenbergia indica. The known compounds were identified as scyphiphin B-1, 1 beta,6 beta,7 alpha,8 alpha,10-pentahydroxy-cis-2-oxabicyclo[4.3.0]nonane, salacianol, 20-hydroxylupan-3-one, and acetylursolic acid, all of which constitute the first record of such compounds from this species. The isolation of iridoids from this plant supports the taxonomic position within the tribe Gratioleae. Salacianol and acetylursolic acid exhibited moderate cytotoxic activity on all tested stomach cancer cell lines.},
	keywords = {IRIDOIDS; Terpenoids; Scrophulariaceae; Lindenbergia indica},
	year = {2022},
	eissn = {1573-8388},
	pages = {450-454}
}

@article{MTMT:33006866,
	title = {The antihypertensive effects of Eucommia ulmoides leaf water/ethanol extracts are chlorogenic acid dependent},
	url = {https://m2.mtmt.hu/api/publication/33006866},
	author = {Wang, Xue-song and Peng, Mi-jun and He, Chun-tao},
	doi = {10.1016/j.jff.2022.105129},
	journal-iso = {J FUNCT FOODS},
	journal = {JOURNAL OF FUNCTIONAL FOODS},
	volume = {94},
	unique-id = {33006866},
	issn = {1756-4646},
	abstract = {The antihypertensive effects of Eucommia ulmoides were determined between normal rats and spontaneously hypertensive rats daily gavaged with leaf extracts, bark extract, chlorogenic acid (CGA), and captopril. Significant composition difference between leaf and bark extracts were noted since CGA was only detected in leaf extract. The overall antihypertensive effects ranked as captopril > CGA > leaf extracts > bark extract, indicating the antihypertensive effect of E. ulmoides extract was CGA-dependent. The hypertension related targets of CGA were screened out and ten KEGG pathways of these targets were significantly enriched, indicating CGA took function in antihypertension via multiple biological processes. Molecular docking revealed CGA bound more tightly to hypertension related targets than captopril, indicating CGA positively participated in antihypertension. However, drug-likeness evaluation displayed the bioavailability of CGA was 5 times lower than captopril, which was consistent with dosage difference in animal experimental. Hence, the antihypertensive effect of CGA was bioavailability limited.},
	keywords = {NETWORK PHARMACOLOGY; antihypertension; Eucommia ulmoides extract; Chlorogenic acid (CGA); Drug-likeness evaluation},
	year = {2022},
	eissn = {2214-9414}
}

@article{MTMT:33006868,
	title = {Determining the in vitro Anti-Aging Effect of the Characteristic Components from Eucommia ulmoides},
	url = {https://m2.mtmt.hu/api/publication/33006868},
	author = {Wang, Xuesong and Wang, Zhihong and Yang, Qiuling and Peng, Sheng and Peng, Mijun},
	doi = {10.32604/jrm.2022.020204},
	journal-iso = {J RENEW MATERIALS},
	journal = {JOURNAL OF RENEWABLE MATERIALS},
	unique-id = {33006868},
	issn = {2164-6325},
	abstract = {To evaluate the potential anti-aging ability of Eucommia ulmoides, four characteristic components (chlorogenic acid, geniposidic acid, aucubin, quercetin) were selected to assess their effects on H2O2-induced oxidative damage model of human umbilical vein endothelial cell (HUVEC). Oxidative damage indexes, inflammatory factors, cell cycle, cell apoptosis, cell senescence, and their related proteins were analyzed by methyl thiazolyl tetrazolium (MTT) assay, enzyme-linked immunosorbent assay (ELISA), propidium iodide (PI) staining, annexin V-FITC/ PI double staining, SA beta-galactosidase staining, and western blotting (WB). The results showed that H2O2-induced cell growth inhibition rate decreased as supplementation with characteristic components when compared to H2O2 group. Meanwhile, the contents of antioxidant indexes (reactive oxygen species, lactate dehydrogenase, molondialdehyde, superoxide dismutase, glutathione), inflammatory factors (nuclear factor kappa-B, intercellular cell adhesion molecule-1, vascular cell adhesion protein 1), and functional factors (NO, Endothelin-1) in charac-teristic components treated groups improved if comparison with H2O2 group, suggesting the characteristic com-ponents of E. ulmoides could alleviate H2O2-induced oxidative damage. Moreover, cell cycle, cell apoptosis, cell senescence, and their related proteins under characteristic components treatment exhibited a better effect than under H2O2 treatment, implying the characteristic components could participate in anti-aging via multiple path-ways. These results manifested that the characteristic components of E. ulmoides posses the capacity of anti-aging, which provided a basis for investigating the anti-aging ability of E. ulmoides itself.},
	keywords = {OXIDATIVE DAMAGE; cell senescence; Anti-aging; Eucommia ulmoides; characteristic components},
	year = {2022},
	eissn = {2164-6341}
}

@article{MTMT:30969586,
	title = {In vitro antimicrobial and antioxidant activity evaluation of melampyrum arvense l. var. elatius boiss. and sedum spurium m. bieb. extracts},
	url = {https://m2.mtmt.hu/api/publication/30969586},
	author = {Karadağ, Ayşe Esra and Tosun, Fatma},
	doi = {10.23893/1307-2080.APS.05712},
	journal-iso = {Acta Pharmaceutica Sciencia},
	journal = {Acta Pharmaceutica Sciencia},
	volume = {57},
	unique-id = {30969586},
	issn = {2636-8552},
	year = {2019},
	eissn = {1307-2080},
	pages = {193-201}
}

@article{MTMT:3347203,
	title = {Anti-inflammatory Activity of Melampyrum barbatum and Isolation of Iridoid and Flavonoid Compounds},
	url = {https://m2.mtmt.hu/api/publication/3347203},
	author = {Háznagyné Radnai, Erzsébet and Fási, Laura and Wéber, Edit and Pinke, Gyula and Király, Botond Gergely and Sztojkov-Ivanov, Anita and Gáspár, Róbert and Hohmann, Judit},
	doi = {10.1177/1934578x1801300301},
	journal-iso = {NAT PROD COMMUN},
	journal = {NATURAL PRODUCT COMMUNICATIONS},
	volume = {13},
	unique-id = {3347203},
	issn = {1934-578X},
	abstract = {Melampyrum barbatum Waldst. & Kit. ex Willd. (Scrophulariaceae) has been used in traditional medicine for the treatment of rheumatic complaints and different skin diseases. In the course of our study the anti-inflammatory activity of the aerial parts of M barbatum was evaluated. A MeOH extract was prepared and consecutively partitioned with CHCl3, EtOAc and n-BuOH. The fractions were assayed in in vivo carrageenan-induced rat paw oedema model. The intraperitoneally administered n-BuOH phase exerted marked inhibitory effect (33.6 %, p < 0.01). Multistep chromatographic separation afforded mussaenoside and aucubine from n-BuOH fraction. Moreover, 8-epiloganin, loganic acid and mussaenoside were obtained from EtOAc fraction and apigenin, luteolin, benzoic acid and galactitol from CHCl3 fraction. These data validate the ethnomedicinal use of M barbatum for the treatment of inflammatory diseases and reveal that iridoids and flavonoids could be responsible for the anti-inflammatory effect of this species.},
	keywords = {Flavonoids; IRIDOIDS; anti-inflammatory activity; Melampyrum barbatum; Scrophulariaceae},
	year = {2018},
	eissn = {1555-9475},
	pages = {235-236},
	orcid-numbers = {Háznagyné Radnai, Erzsébet/0000-0003-4034-5989; Wéber, Edit/0000-0002-5904-0619; Pinke, Gyula/0000-0002-9956-1363; Király, Botond Gergely/0000-0002-8439-2616; Gáspár, Róbert/0000-0002-1571-7579; Hohmann, Judit/0000-0002-2887-6392}
}

@article{MTMT:27166178,
	title = {Four New Acylated Iridoid Glycosides from the Aerial Part of Veronicastrum sibiricum and Their Antioxidant Response Element-Inducing Activity},
	url = {https://m2.mtmt.hu/api/publication/27166178},
	author = {Kim, MI and Kim, CY},
	doi = {10.1002/cbdv.201700447},
	journal-iso = {CHEM BIODIVERS},
	journal = {CHEMISTRY & BIODIVERSITY},
	volume = {15},
	unique-id = {27166178},
	issn = {1612-1872},
	year = {2018},
	eissn = {1612-1880}
}

@article{MTMT:26647816,
	title = {Structural identification of iridoids from leaves of Hydrangea macrophylla},
	url = {https://m2.mtmt.hu/api/publication/26647816},
	author = {CHEN, Ya-jun WANG Zhi-bin YU Ying GAO Yan YANG Chun-juan BI Xue-yan KUANG Hai-xue},
	doi = {10.7501/j.issn.0253-2670.2017.02.002},
	journal-iso = {CHINESE TRADITIONAL AND HERBAL DRUGS},
	journal = {CHINESE TRADITIONAL AND HERBAL DRUGS},
	volume = {48},
	unique-id = {26647816},
	issn = {0253-2670},
	year = {2017},
	pages = {232-235}
}