TY - JOUR AU - Paulk, A.C. AU - Salami, P. AU - Zelmann, R. AU - Cash, S.S. TI - Electrode Development for Epilepsy Diagnosis and Treatment JF - NEUROSURGERY CLINICS OF NORTH AMERICA J2 - NEUROSURG CLIN N AM VL - 35 PY - 2024 IS - 1 SP - 135 EP - 149 PG - 15 SN - 1042-3680 DO - 10.1016/j.nec.2023.09.003 UR - https://m2.mtmt.hu/api/publication/34479998 ID - 34479998 N1 - Export Date: 05 January 2024; Cited By: 0; Correspondence Address: A.C. Paulk; Department of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital and Harvard Medical School, Boston, 55 Fruit Street, 02114, United States; email: apaulk@mgh.harvard.edu; CODEN: NCNAF LA - English DB - MTMT ER - TY - JOUR AU - Sandoval-Pistorius, S.S. AU - Hacker, M.L. AU - Waters, A.C. AU - Wang, J. AU - Provenza, N.R. AU - de, Hemptinne C. AU - Johnson, K.A. AU - Morrison, M.A. AU - Cernera, S. TI - Advances in Deep Brain Stimulation: From Mechanisms to Applications JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 43 PY - 2023 IS - 45 SP - 7575 EP - 7586 PG - 12 SN - 0270-6474 DO - 10.1523/JNEUROSCI.1427-23.2023 UR - https://m2.mtmt.hu/api/publication/34539411 ID - 34539411 N1 - Department of Neurological Surgery, University of California–San Francisco, San Francisco, CA 94143, United States Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, United States Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States Department of Neurology, University of Minnesota, Minneapolis, MN 55455, United States Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, United States Department of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL 32608, United States Department of Radiology and Biomedical Imaging, University of California–San Francisco, San Francisco, CA 94143, United States Export Date: 29 January 2024 CODEN: JNRSD Correspondence Address: Sandoval-Pistorius, S.S.; Department of Neurological Surgery, United States; email: stephanie.sandovalpistorius@ucsf.edu LA - English DB - MTMT ER - TY - JOUR AU - Shelchkova, N.D. AU - Downey, J.E. AU - Greenspon, C.M. AU - Okorokova, E.V. AU - Sobinov, A.R. AU - Verbaarschot, C. AU - He, Q. AU - Sponheim, C. AU - Tortolani, A.F. AU - Moore, D.D. AU - Kaufman, M.T. AU - Lee, R.C. AU - Satzer, D. AU - Gonzalez-Martinez, J. AU - Warnke, P.C. AU - Miller, L.E. AU - Boninger, M.L. AU - Gaunt, R.A. AU - Collinger, J.L. AU - Hatsopoulos, N.G. AU - Bensmaia, S.J. TI - Microstimulation of human somatosensory cortex evokes task-dependent, spatially patterned responses in motor cortex JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 14 PY - 2023 IS - 1 SN - 2041-1723 DO - 10.1038/s41467-023-43140-2 UR - https://m2.mtmt.hu/api/publication/34539410 ID - 34539410 N1 - Committee on Computational Neuroscience, University of Chicago, Chicago, IL, United States Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL, United States Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, United States Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands Neuroscience Institute, University of Chicago, Chicago, IL, United States Schwab Rehabilitation Hospital, Chicago, IL, United States Department of Neurological Surgery, University of Chicago, Chicago, IL, United States Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, United States Department of Physiology, Northwestern University, Chicago, IL, United States Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, United States Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States Cited By :1 Export Date: 29 January 2024 Correspondence Address: Downey, J.E.; Department of Organismal Biology and Anatomy, United States; email: johndowney@uchicago.edu LA - English DB - MTMT ER - TY - JOUR AU - Aron, Olivier AU - Krieg, Julien AU - Brissart, Helene AU - Abdallah, Chifaou AU - Colnat-Coulbois, Sophie AU - Jonas, Jacques AU - Maillard, Louis TI - Naming impairments evoked by focal cortical electrical stimulation in the ventral temporal cortex correlate with increased functional connectivity JF - NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY J2 - NEUROPHYSIOL CLIN VL - 52 PY - 2022 IS - 4 SP - 312 EP - 322 PG - 11 SN - 0987-7053 DO - 10.1016/j.neucli.2022.06.002 UR - https://m2.mtmt.hu/api/publication/33229863 ID - 33229863 N1 - Department of Neurology, University Hospital of Nancy, Lorraine University, Nancy, F-54000, France Department of Neurosurgery, University Hospital of Nancy, Lorraine University, Nancy, F-54000, France Research Center for Automatic Control of Nancy (CRAN), Lorraine University, CNRS, UMR, Vandoeuvre, 7039, France Neurology and Neurosurgery Department, Montreal Neurological Institute (C.A.) McGill University, Montreal, QC, Canada Export Date: 29 January 2024 CODEN: NCLIE Correspondence Address: Aron, O.; Université de Lorraine, France; email: o.aron@chru-nancy.fr AB - Background: High-frequency cortical electrical stimulations (HF-CES) are the gold standard for presurgical functional mapping. In the dominant ventral temporal cortex (VTC) HF-CES can elicit transient naming impairment (eloquent sites), defining a basal temporal language area (BTLA).Objective: Whether naming impairments induced by HF-CES within the VTC are related to a spe-cific pattern of connectivity of the BTLA within the temporal lobe remains unknown. We addressed this issue by comparing the connectivity of eloquent and non-eloquent sites from the VTC using cortico-cortical evoked potentials (CCEP).Methods: Low frequency cortical electrical stimulations (LF-CES) were used to evoke CCEP in nine individual brains explored with Stereo-Electroencephalography. We compared the connec-tivity of eloquent versus non eloquent sites within the VTC using Pearson's correlation matrix.Results: Overall, within the VTC, eloquent sites were associated with increased functional con-nectivity compared to non-eloquent sites. Among the VTC structures, this pattern holds true for the inferior temporal gyrus and the parahippocampal gyrus while the fusiform gyrus specifically showed a high connectivity in both non eloquent and eloquent sites.Conclusions: Our findings suggest that the cognitive effects of focal HF-CES are related to the functional connectivity properties of the stimulated sites, and therefore to the disturbance of a wide cortical network. They further suggest that functional specialization of a cortical region emerges from its specific pattern of functional connectivity. Cortical electrical stimulation func-tional mapping protocols including LF coupled to HF-CES could provide valuable data character-izing both local and distant functional architecture.(c) 2022 The Authors. Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). LA - English DB - MTMT ER - TY - JOUR AU - Dickey, Adam S. AU - Alwaki, Abdulrahman AU - Kheder, Ammar AU - Willie, Jon T. AU - Drane, Daniel L. AU - Pedersen, Nigel P. TI - The Referential Montage Inadequately Localizes Corticocortical Evoked Potentials in Stereoelectroencephalography JF - JOURNAL OF CLINICAL NEUROPHYSIOLOGY J2 - J CLIN NEUROPHYSIOL VL - 39 PY - 2022 IS - 5 SP - 412 EP - 418 PG - 7 SN - 0736-0258 DO - 10.1097/WNP.0000000000000792 UR - https://m2.mtmt.hu/api/publication/33006262 ID - 33006262 N1 - Department of Neurology, Emory University, Emory Epilepsy Center, Atlanta, GA, United States Departments of Pediatrics and Neurology, Atlanta, GA, United States Department of Neurosurgery, Emory University, Atlanta, GA, United States Emory Neuromodulation Technology Innovation Center, Emory University, Georgia Institute of Technology, Atlanta, GA, United States Cited By :1 Export Date: 29 January 2024 CODEN: JCNEE Correspondence Address: Pedersen, N.P.; Department of Neurosurgery, 101 Woodruff Circle, WMB 6107, United States; email: npeders@emory.edu AB - Purpose: Corticocortical evoked potentials (CCEPs) resulting from single pulse electrical stimulation are increasingly used to understand seizure networks, as well as normal brain connectivity. However, we observed that when using depth electrodes, traditional measures of CCEPs amplitude using a referential montage can be falsely localizing, often to white matter. Methods: We pooled 27 linear electrode arrays targeting the amygdala, hippocampus, or cingulate cortex from eight participants. Using postoperative imaging, we classified contacts as being in gray matter, white matter, or bordering each and measured the amplitude using the root-mean-squared deviation from baseline in a referential, common average, bipolar, or Laplacian montage. Results: Of 27 electrode contacts, 25 (93%) had a significantly higher mean amplitude when in gray matter than in white matter using a Laplacian montage, which was significantly more than the 12 of 27 electrodes (44%) when using a referential montage (P = 0.0003, Fisher exact test). The area under the curve for a receiver operating characteristic classifying contacts as gray or white matter was significantly higher for either the Laplacian (0.79) or the bipolar (0.72) montage when compared with either the common average (0.56) or the referential (0.51) montage (P <= 0.005, bootstrap). Conclusions: Both the Laplacian and bipolar montages were superior to the common average or referential montage in localizing CCEPs to gray matter. These montages may be more appropriate for interpreting CCEPs when using depth electrodes than the referential montage, which has typically been used in prior studies of CCEPs with subdural grids. LA - English DB - MTMT ER - TY - JOUR AU - Smith, Ezra E. AU - Choi, Ki Sueng AU - Veerakumar, Ashan AU - Obatusin, Mosadoluwa AU - Howell, Bryan AU - Smith, Andrew H. AU - Tiruvadi, Vineet AU - Crowell, Andrea L. AU - Riva-Posse, Patricio AU - Alagapan, Sankaraleengam AU - Rozell, Christopher J. AU - Mayberg, Helen S. AU - Waters, Allison C. TI - Time-frequency signatures evoked by single-pulse deep brain stimulation to the subcallosal cingulate JF - FRONTIERS IN HUMAN NEUROSCIENCE J2 - FRONT HUM NEUROSCI VL - 16 PY - 2022 PG - 11 SN - 1662-5161 DO - 10.3389/fnhum.2022.939258 UR - https://m2.mtmt.hu/api/publication/33167384 ID - 33167384 N1 - Private Practice, Pima, Tucson, AZ, United States Departments of Psychiatry, Neuroscience, Neurology, Neurosurgery and Radiology, Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States Department of Psychiatry, Schulich School of Medicine and Dentistry, London, ON, Canada Department of Biomedical Engineering, Duke University, Durham, NC, United States Emory University School of Medicine, Atlanta, GA, United States Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA, United States Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States Cited By :3 Export Date: 31 October 2023 Correspondence Address: Waters, A.C.; Departments of Psychiatry, United States; email: allison.waters@mssm.edu AB - Precision targeting of specific white matter bundles that traverse the subcallosal cingulate (SCC) has been linked to efficacy of deep brain stimulation (DBS) for treatment resistant depression (TRD). Methods to confirm optimal target engagement in this heterogenous region are now critical to establish an objective treatment protocol. As yet unexamined are the time-frequency features of the SCC evoked potential (SCC-EP), including spectral power and phase-clustering. We examined these spectral features-evoked power and phase clustering-in a sample of TRD patients (n = 8) with implanted SCC stimulators. Electroencephalogram (EEG) was recorded during wakeful rest. Location of electrical stimulation in the SCC target region was the experimental manipulation. EEG was analyzed at the surface level with an average reference for a cluster of frontal sensors and at a time window identified by prior study (50-150 ms). Morlet wavelets generated indices of evoked power and inter-trial phase clustering. Enhanced phase clustering at theta frequency (4-7 Hz) was observed in every subject and was significantly correlated with SCC-EP magnitude, but only during left SCC stimulation. Stimulation to dorsal SCC evinced stronger phase clustering than ventral SCC. There was a weak correlation between phase clustering and white matter density. An increase in evoked delta power (2-4 Hz) was also coincident with SCC-EP, but was less consistent across participants. DBS evoked time-frequency features index mm-scale changes to the location of stimulation in the SCC target region and correlate with structural characteristics implicated in treatment optimization. Results also imply a shared generative mechanism (inter-trial phase clustering) between evoked potentials evinced by electrical stimulation and evoked potentials evinced by auditory/visual stimuli and behavioral tasks. Understanding how current injection impacts downstream cortical activity is essential to building new technologies that adapt treatment parameters to individual differences in neurophysiology. LA - English DB - MTMT ER - TY - JOUR AU - Togo, Masaya AU - Matsumoto, Riki AU - Usami, Kiyohide AU - Kobayashi, Katsuya AU - Takeyama, Hirofumi AU - Nakae, Takuro AU - Shimotake, Akihiro AU - Kikuchi, Takayuki AU - Yoshida, Kazumichi AU - Matsuhashi, Masao AU - Kunieda, Takeharu AU - Miyamoto, Susumu AU - Takahashi, Ryosuke AU - Ikeda, Akio TI - Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential JF - NEUROIMAGE J2 - NEUROIMAGE VL - 263 PY - 2022 PG - 14 SN - 1053-8119 DO - 10.1016/j.neuroimage.2022.119639 UR - https://m2.mtmt.hu/api/publication/33229822 ID - 33229822 N1 - Funding Agency and Grant Number: Ministry of Education, Culture, Sports, Science and Technology (MEXT) KAKENHI; Ministry of Education, Culture, Sports, Science and Technology (MEXT) KAKENHI [18K19514, 20H05471, 22H04777, 22H02945, 20K16575, 19H03574] Funding text: This work was supported by the Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) KAKENHI. RM reports grants from MEXT, KAKENHI 18K19514, 20H05471, 22H04777, 22H02945, MT reports grants from 20K16575, and AI reports grants from 19H03574. We would like to thank Prof. Naoyuki Sato for his technical advice and help in performing the per-mutation test. AB - The medial parietal cortices are components of the default mode network (DMN), which are active in the resting state. The medial parietal cortices include the precuneus and the dorsal posterior cingulate cortex (dPCC). Few studies have mentioned differences in the connectivity in the medial parietal cortices, and these differences have not yet been precisely elucidated. Electrophysiological connectivity is essential for understanding cortical function or functional differences. Since little is known about electrophysiological connections from the medial parietal cortices in humans, we evaluated distinct connectivity patterns in the medial parietal cortices by constructing a standardized connectivity map using cortico-cortical evoked potential (CCEP). This study included nine patients with partial epilepsy or a brain tumor who underwent chronic intracranial electrode placement covering the medial parietal cortices. Single-pulse electrical stimuli were delivered to the medial parietal cortices (38 pairs of electrodes). Responses were standardized using the z-score of the baseline activity, and a response density map was constructed in the Montreal Neurological Institutes (MNI) space. The precuneus tended to connect with the inferior parietal lobule (IPL), the occipital cortex, superior parietal lobule (SPL), and the dorsal premotor area (PMd) (the four most active regions, in descending order), while the dPCC tended to connect to the middle cingulate cortex, SPL, precuneus, and IPL. The connectivity pattern differs significantly between the precuneus and dPCC stimulation ( p < 0.05). Regarding each part of the medial parietal cortices, the distributions of parts of CCEP responses resembled those of the functional connectivity database. Based on how the dPCC was connected to the medial frontal area, SPL, and IPL, its connectivity pattern could not be explained by DMN alone, but suggested a mixture of DMN and the frontoparietal cognitive network. These findings improve our understanding of the connectivity profile within the medial parietal cortices. The electrophysiological connectivity is the basis of propagation of electrical activities in patients with epilepsy. In addition, it helps us to better understand the epileptic network arising from the medial parietal cortices. LA - English DB - MTMT ER - TY - JOUR AU - Crocker, Britni AU - Ostrowski, Lauren AU - Williams, Ziv M. AU - Dougherty, Darin D. AU - Eskandar, Emad N. AU - Widge, Alik S. AU - Chu, Catherine J. AU - Cash, Sydney S. AU - Paulk, Angelique C. TI - Local and distant responses to single pulse electrical stimulation reflect different forms of connectivity JF - NEUROIMAGE J2 - NEUROIMAGE VL - 237 PY - 2021 PG - 11 SN - 1053-8119 DO - 10.1016/j.neuroimage.2021.118094 UR - https://m2.mtmt.hu/api/publication/32277679 ID - 32277679 N1 - Funding Agency and Grant Number: NINDS [K24-NS08856801A1]; Tiny Blue Dot Foundation; United States Department of Energy Computational Sciences Graduate Fellowship [DE-FG0297ER25308]; U.S. Army Research Office and Defense Advanced Research Projects Agency (DARPA) [W911NF-14-2-0045] Funding text: We would like to especially thank the patients who participated for their time and help. We thank Erica Johnson, Gavin Belok, Kara Farnes, Jessica Chang, Daniel Soper, and Mia Borzello for technical assistance, particularly in the MRI reconstruction and registration, and Enterprise Research Infrastructure & Services at Partners Healthcare for their indepth support and for the provision of the ERISOne Linux Computing Cluster. This work was supported by NINDS-K24 [K24-NS08856801A1]; the Tiny Blue Dot Foundation; and the United States Department of Energy Computational Sciences Graduate Fellowship [DE-FG0297ER25308] to BC. This research was sponsored by the U.S. Army Research Office and Defense Advanced Research Projects Agency (DARPA) under Cooperative Agreement Number W911NF-14-2-0045 issued by ARO contracting office in support of DARPA's SUBNETS Program. The views, opinions, and/or findings expressed are those of the authors and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. AB - Measuring connectivity in the human brain involves innumerable approaches using both noninvasive (fMRI, EEG) and invasive (intracranial EEG or iEEG) recording modalities, including the use of external probing stimuli, such as direct electrical stimulation. To examine how different measures of connectivity correlate with one another, we compared 'passive' measures of connectivity during resting state conditions to the more 'active' probing measures of connectivity with single pulse electrical stimulation (SPES). We measured the network engagement and spread of the cortico-cortico evoked potential (CCEP) induced by SPES at 53 out of 104 total sites across the brain, including cortical and subcortical regions, in patients with intractable epilepsy (N = 11) who were undergoing intracranial recordings as a part of their clinical care for identifying seizure onset zones. We compared the CCEP network to functional, effective, and structural measures of connectivity during a resting state in each patient. Functional and effective connectivity measures included correlation or Granger causality measures applied to stereoEEG (sEEGs) recordings. Structural connectivity was derived from diffusion tensor imaging (DTI) acquired before intracranial electrode implant and monitoring (N = 8). The CCEP network was most similar to the resting state voltage correlation network in channels near to the stimulation location. In contrast, the distant CCEP network was most similar to the DTI network. Other connectivity measures were not as similar to the CCEP network. These results demonstrate that different connectivity measures, including those derived from active stimulation-based probing, measure different, complementary aspects of regional interrelationships in the brain. LA - English DB - MTMT ER - TY - JOUR AU - Giampiccolo, D. AU - Parmigiani, S. AU - Basaldella, F. AU - Russo, S. AU - Pigorini, A. AU - Rosanova, M. AU - Cattaneo, L. AU - Sala, F. TI - Recording cortico-cortical evoked potentials of the human arcuate fasciculus under general anaesthesia JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 132 PY - 2021 IS - 8 SP - 1966 EP - 1973 PG - 8 SN - 1388-2457 DO - 10.1016/j.clinph.2021.03.044 UR - https://m2.mtmt.hu/api/publication/32277265 ID - 32277265 N1 - Funding Agency and Grant Number: Fondazione Cariverona (Progetto Neuro-Connect); University of Verona (Bando Ricerca di Base); European Union's Horizon 2020 Framework Programme for Research and Innovation [945539]; Tiny Blue Dot Foundation Funding text: This work was supported by Fondazione Cariverona (Progetto Neuro-Connect), the University of Verona (Bando Ricerca di Base), the European Union's Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No.945539 (Human Brain Project SGA3 to S.P., A.P., S.R. and M.R.), and from the Tiny Blue Dot Foundation (to S.P., A.P., S.R. and M.R.). AB - Objective: We examined the feasibility of using cortico-cortical evoked potentials (CCEPs) to monitor the major cortical white matter tract involved in language, the arcuate fasciculus (AF), during surgery under general anaesthesia.Methods: We prospectively recruited nine patients undergoing surgery for lesions in the left peri-sylvian cortex, for whom awake surgery was not indicated. High angular resolution diffusion imaging (HARDI) tractography was used to localise frontal and temporal AF terminations, which guided intraoperative cortical strip placement.Results: CCEPs were successfully evoked in 5/9 patients, showing a positive potential (P1) at 12 ms and a negative component (N1) at 21 ms when stimulating from the frontal lobe and recording in the temporal lobe. CCEP responses peaked in the posterior middle temporal gyrus. No CCEPs were evoked when stimulating temporal sites and recording from frontal contacts.Conclusion: For the first time, we show that CCEPs can be evoked from the peri-sylvian cortices also in adult patients who are not candidates for awake procedures. Our results are akin to those described in the awake setting and suggest the recorded activity is conveyed by the arcuate fasciculus.Significance: This intraoperative approach may have promising implications in reducing deficits in patients that require surgery in language areas under general anesthesia. (C) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Gronlier, Eloise AU - Vendramini, Estelle AU - Volle, Julien AU - Wozniak-Kwasniewska, Agata AU - Santos, Noelia Anton AU - Coizet, Veronique AU - Duveau, Venceslas AU - David, Olivier TI - Single-pulse electrical stimulation methodology in freely moving rat JF - JOURNAL OF NEUROSCIENCE METHODS J2 - J NEUROSCI METH VL - 353 PY - 2021 PG - 9 SN - 0165-0270 DO - 10.1016/j.jneumeth.2021.109092 UR - https://m2.mtmt.hu/api/publication/32277683 ID - 32277683 N1 - Funding Agency and Grant Number: European Research Council [790093]; Region Auvergne-Rhone-Alpes; "Association Nationale Recherche Technologie" (ANRT, CIFRE, France) [2017/1269] Funding text: Authors gratefully acknowledge the support of European Research Council (ERC-2017-PoC, Grant ID 790093, "EXCITATOR: Active probing of brain excitability by electrical micro-stimulations for drug discovery"). This work was funded by Region Auvergne-Rhone-Alpes under the grant agreement 2017 FRI Transfert EXCILAB. The study was also supported by "Association Nationale Recherche Technologie" (ANRT, CIFRE no 2017/1269, France). AB - Background: Cortico-cortical evoked potentials (CCEP) are becoming popular to infer brain connectivity and cortical excitability in implanted refractory epilepsy patients. Our goal was to transfer this methodology to the freely moving rodent.New method: CCEP were recorded on freely moving Sprague-Dawley rats, from cortical and subcortical areas using depth electrodes. Electrical stimulation was applied using 1 ms biphasic current pulse, cathodic first, at a frequency of 0.5 Hz, with intensities ranging from 0.2 to 0.8 mA. Data were then processed in a similar fashion to human clinical studies, which included epoch selection, artefact correction and smart averaging.Results: For a large range of tested intensities, we recorded CCEPs with very good signal to noise ratio and reproducibility between animals, without any behavioral modification. The CCEP were composed of different components according to recorded and stimulated sites, similarly to human recordings. Comparison with existing methods: We minimally adapted a clinically-motivated methodology to a freely moving rodent model to achieve high translational relevance of future preclinical studies.Conclusions: Our results indicate that the CCEP methodology can be applied to freely moving rodents and transferred to preclinical research. This will be of interest to address various neuroscientific questions, in physiological and pathological conditions. LA - English DB - MTMT ER - TY - JOUR AU - Herrero, Jose L. AU - Smith, Alexander AU - Mishra, Akash AU - Markowitz, Noah AU - Mehta, Ashesh D. AU - Bickel, Stephan TI - Inducing neuroplasticity through intracranial theta-burst stimulation in the human sensorimotor cortex JF - JOURNAL OF NEUROPHYSIOLOGY J2 - J NEUROPHYSIOL VL - 126 PY - 2021 IS - 5 SP - 1723 EP - 1739 PG - 17 SN - 0022-3077 DO - 10.1152/jn.00320.2021 UR - https://m2.mtmt.hu/api/publication/33006202 ID - 33006202 N1 - Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States Department of Neurosurgery, Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, United States Department of Neurology, Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, United States Export Date: 21 October 2022 CODEN: JONEA Correspondence Address: Herrero, J.L.; Feinstein Institutes for Medical Research, United States; email: jherreroru@northwell.edu Chemicals/CAS: carbamazepine, 298-46-4, 8047-84-5; cenobamate, 913088-80-9; clobazam, 22316-47-8; clonazepam, 1622-61-3; felbamate, 25451-15-4; lacosamide, 175481-36-4; lamotrigine, 84057-84-1; levetiracetam, 102767-28-2; perampanel, 380917-97-5; primidone, 125-33-7; topiramate, 97240-79-4 Tradenames: Grass S12D, Grass; Xltek Quantum 256, Natus Manufacturers: Grass; Natus AB - The progress of therapeutic neuromodulation greatly depends on improving stimulation parameters to most efficiently induce neuroplasticity effects. Intermittent theta-burst stimulation (iTBS), a form of electrical stimulation that mimics natural brain activity patterns, has proved to efficiently induce such effects in animal studies and rhythmic transcranial magnetic stimulation studies in humans. However, little is known about the potential neuroplasticity effects of iTBS applied through intracranial electrodes in humans. This study characterizes the physiological effects of intracranial iTBS in humans and compare them with alpha-frequency stimulation, another frequently used neuromodulatory pattern. We applied these two stimulation patterns to well-defined regions in the sensorimotor cortex, which elicited contralateral hand muscle contractions during clinical mapping, in patients with epilepsy implanted with intracranial electrodes. Treatment effects were evaluated using oscillatory coherence across areas connected to the treatment site, as defined with corticocortical-evoked potentials. Our results show that iTBS increases coherence in the beta-frequency band within the sensorimotor network indicating a potential neuroplasticity effect. The effect is specific to the sensorimotor system, the beta band, and the stimulation pattern and outlasted the stimulation period by similar to 3 min. The effect occurred in four out of seven subjects depending on the buildup of the effect during iTBS treatment and other patterns of oscillatory activity related to ceiling effects within the beta band and to preexistent coherence within the alpha band. By characterizing the neurophysiological effects of iTBS within well-defined cortical networks, we hope to provide an electrophysiological framework that allows clinicians/researchers to optimize brain stimulation protocols which may have translational value.NEW & NOTEWORTHY theta-Burst stimulation (TBS) protocols in transcranial magnetic stimulation studies have shown improved treatment efficacy in a variety of neuropsychiatric disorders. The optimal protocol to induce neuroplasticity in invasive direct electrical stimulation approaches is not known. We report that intracranial TBS applied in human sensorimotor cortex increases local coherence of preexistent beta rhythms. The effect is specific to the stimulation frequency and the stimulated network and outlasts the stimulation period by similar to 3 min. LA - English DB - MTMT ER - TY - JOUR AU - Kobayashi, Katsuya AU - Matsumoto, Riki AU - Usami, Kiyohide AU - Matsuhashi, Masao AU - Shimotake, Akihiro AU - Kikuchi, Takayuki AU - Yoshida, Kazumichi AU - Kunieda, Takeharu AU - Miyamoto, Susumu AU - Takahashi, Ryosuke AU - Ikeda, Akio TI - Cortico-cortical evoked potential by single-pulse electrical stimulation is a generally safe procedure JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 132 PY - 2021 IS - 5 SP - 1033 EP - 1040 PG - 8 SN - 1388-2457 DO - 10.1016/j.clinph.2020.12.022 UR - https://m2.mtmt.hu/api/publication/32277682 ID - 32277682 N1 - Department of Neurology, Kyoto University Graduate School of Medicine, Japan Department of Epilepsy, Neurological Institute, Cleveland Clinic, United States Division of Neurology, Kobe University Graduate School of Medicine, Japan Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Japan Department of Neurosurgery, Kyoto University Graduate School of Medicine, Japan Department of Neurosurgery, Ehime University Graduate School of Medicine, Japan Cited By :6 Export Date: 29 January 2024 CODEN: CNEUF Correspondence Address: Matsumoto, R.; Division of Neurology, 7-5-1 Kusunoki-cho, Japan; email: matsumot@med.kobe-u.ac.jp AB - Objective: Cortico-cortical evoked potential (CCEP) by single-pulse electrical stimulation (SPES) is useful to investigate effective connectivity and cortical excitability. We aimed to clarify the safety of CCEPs.Methods: We retrospectively analyzed 29 consecutive patients with intractable partial epilepsy undergoing chronic subdural grid implantation and CCEP recording. Repetitive SPES (1 Hz) was systematically applied to a pair of adjacent electrodes over almost all electrodes. We evaluated the incidences of after discharges (ADs) and clinical seizures.Results: Out of 1283 electrode pairs, ADs and clinical seizures were observed in 12 and 5 pairs (0.94% and 0.39%, per electrode pair) in 7 and 3 patients (23.3% and 10.0%, per patient), respectively. Of the 18-82 pairs per patient, ADs and clinical seizures were induced in 0-4 and 0-3 pairs, respectively. Stimulating 4 SOZ (seizure onset zone) (2.5%) and 8 non-SOZ pairs (0.75%) resulted in ADs. We observed clinical seizures in stimulating 4 SOZ (2.5%) and 1 non-SOZ pair (0.09%). The incidence of clinical seizures varied significantly between SOZ and non-SOZ stimulations (p = 0.001), while the difference in AD incidence tended towards significance (p = 0.058).Conclusion: Although caution should be taken in stimulating SOZ, CCEP is a safe procedure for presurgical evaluation. Significance: CCEP is safe under the established protocol.(c) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Sala, Francesco AU - Giampiccolo, Davide AU - Cattaneo, Luigi TI - Novel Asleep Techniques for Intraoperative Assessment of Brain Connectivity JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 12 PY - 2021 PG - 5 SN - 1664-2295 DO - 10.3389/fneur.2021.687030 UR - https://m2.mtmt.hu/api/publication/32277268 ID - 32277268 N1 - Funding Agency and Grant Number: Fondazione Cassa di Risparmio di Verona Funding text: This work was supported by the grant NEUROCONNECT issued to FS by the Fondazione Cassa di Risparmio di Verona. LA - English DB - MTMT ER - TY - JOUR AU - Arbune, A.A. AU - Popa, I. AU - Mindruta, I. AU - Beniczky, Sándor AU - Donos, C. AU - Daneasa, A. AU - Mălîia, M.D. AU - Băjenaru, O.A. AU - Ciurea, J. AU - Barborica, A. TI - Sleep modulates effective connectivity: A study using intracranial stimulation and recording JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 131 PY - 2020 IS - 2 SP - 529 EP - 541 PG - 13 SN - 1388-2457 DO - 10.1016/j.clinph.2019.09.010 UR - https://m2.mtmt.hu/api/publication/31406152 ID - 31406152 N1 - Department of Neurology, University Emergency Hospital, Bucharest, Romania Department of Clinical Neurosciences, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania Brain Research Group, Romanian Academy, Bucharest, Romania Department of Clinical Neurophysiology, Danish Epilepsy Centre, Dianalund, Denmark and, Department of Clinical Neurophysiology, Aarhus University Hospital; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark Physics Department, University of Bucharest, Bucharest, Romania Neurosurgery Department, Bagdasar-Arseni Hospital, Bucharest, Romania FHC Inc., Bowdoin, ME, United States Cited By :3 Export Date: 18 August 2020 CODEN: CNEUF Correspondence Address: Barborica, A.; Physics Department, Bucharest University, P.O. Box MG-11, Romania; email: andrei.barborica@fizica.unibuc.ro LA - English DB - MTMT ER - TY - CHAP AU - Brogna, C. AU - Pereira, N. AU - Ribas, E.C. AU - Jones, H. AU - Vergani, F. AU - Bassi, S. AU - Ashkan, K. AU - Bhangoo, R. ED - Andreas, Lehrer ED - Kristin, Mueller TI - BRAIN MAPPING AND NEURO-MONITORING IN LOW GRADE GLIOMA SURGERY: CURRENT CHALLENGES AND FUTURE PERSPECTIVES T2 - Encyclopedia of Surgery: Volume 1: (22 Volume Set) VL - 1 PB - Nova Science Publishers, Inc. CY - New York, New York SN - 9781536183290 PY - 2020 SP - 7097 EP - 7116 PG - 20 UR - https://m2.mtmt.hu/api/publication/34539414 ID - 34539414 LA - English DB - MTMT ER - TY - JOUR AU - File, Bálint AU - Nánási, Tibor AU - Tóth, E. AU - Bokodi, Virág AU - Tóth, Brigitta AU - Hajnal, Boglárka Zsófia AU - Balogh-Kardos, Zsófia Klára AU - Entz, László AU - Erőss, Loránd AU - Ulbert, István AU - Fabó, Dániel TI - Reorganization of Large-Scale Functional Networks during Low-Frequency Electrical Stimulation of the Cortical Surface JF - INTERNATIONAL JOURNAL OF NEURAL SYSTEMS J2 - INT J NEURAL SYST VL - 30 PY - 2020 IS - 3 PG - 15 SN - 0129-0657 DO - 10.1142/S0129065719500229 UR - https://m2.mtmt.hu/api/publication/30868010 ID - 30868010 N1 - Funding Agency and Grant Number: Hungarian Brain Research Program Grants [2017-1.2.1-NKP-2017-00002]; European Social Fund [EFOP-3.6.3-VEKOP-16-2017-00002] Funding text: BF is supported by the Hungarian Brain Research Program Grants (Grant Nos. 2017-1.2.1-NKP-2017-00002) and the European Social Fund (EFOP-3.6.3-VEKOP-16-2017-00002). The authors are willing to share their data upon personal request. First and second authors contributed equally. LA - English DB - MTMT ER - TY - JOUR AU - Hebbink, Jurgen AU - Huiskamp, Geertjan AU - van Gils, Stephan A. AU - Leijten, Frans S. S. AU - Meijer, Hil G. E. TI - Pathological responses to single-pulse electrical stimuli in epilepsy: The role of feedforward inhibition JF - EUROPEAN JOURNAL OF NEUROSCIENCE J2 - EUR J NEUROSCI VL - 51 PY - 2020 IS - 4 SP - 1122 EP - 1136 PG - 15 SN - 0953-816X DO - 10.1111/ejn.14562 UR - https://m2.mtmt.hu/api/publication/31023490 ID - 31023490 N1 - Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Centre Utrecht, Utrecht, Netherlands Department of Applied Mathematics and Technical Medical Centre, University of Twente, Enschede, Netherlands Cited By :1 Export Date: 18 August 2020 CODEN: EJONE Correspondence Address: Hebbink, J.; Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Centre UtrechtNetherlands; email: g.j.hebbink@utwente.nl AB - Delineation of epileptogenic cortex in focal epilepsy patients may profit from single-pulse electrical stimulation during intracranial EEG recordings. Single-pulse electrical stimulation evokes early and delayed responses. Early responses represent connectivity. Delayed responses are a biomarker for epileptogenic cortex, but up till now, the precise mechanism generating delayed responses remains elusive. We used a data-driven modelling approach to study early and delayed responses. We hypothesized that delayed responses represent indirect responses triggered by early response activity and investigated this for 11 patients. Using two coupled neural masses, we modelled early and delayed responses by combining simulations and bifurcation analysis. An important feature of the model is the inclusion of feedforward inhibitory connections. The waveform of early responses can be explained by feedforward inhibition. Delayed responses can be viewed as second-order responses in the early response network which appear when input to a neural mass falls below a threshold forcing it temporarily to a spiking state. The combination of the threshold with noisy background input explains the typical stochastic appearance of delayed responses. The intrinsic excitability of a neural mass and the strength of its input influence the probability at which delayed responses to occur. Our work gives a theoretical basis for the use of delayed responses as a biomarker for the epileptogenic zone, confirming earlier clinical observations. The combination of early responses revealing effective connectivity, and delayed responses showing intrinsic excitability, makes single-pulse electrical stimulation an interesting tool to obtain data for computational models of epilepsy surgery. LA - English DB - MTMT ER - TY - JOUR AU - Lalwani, A.M. AU - Yilmaz, A. AU - Bisgin, H. AU - Ugur, Z. AU - Akyol, S. AU - Graham, S.F. TI - The biochemical profile of post-mortem brain from people who suffered from epilepsy reveals novel insights into the etiopathogenesis of the disease JF - METABOLITES J2 - METABOLITES VL - 10 PY - 2020 IS - 6 SP - 1 EP - 16 PG - 16 SN - 2218-1989 DO - 10.3390/metabo10060261 UR - https://m2.mtmt.hu/api/publication/31406149 ID - 31406149 N1 - Export Date: 18 August 2020 Correspondence Address: Graham, S.F.; Department of Obstetrics and Gynecology, Beaumont Health System, Oakland University-William Beaumont School of Medicine, Beaumont Research Institute, Beaumont Health, 3601 W. 13 Mile Road, United States; email: stewart.graham@beaumont.edu Export Date: 8 September 2020 Correspondence Address: Graham, S.F.; Department of Obstetrics and Gynecology, Beaumont Health System, Oakland University-William Beaumont School of Medicine, Beaumont Research Institute, Beaumont Health, 3601 W. 13 Mile Road, United States; email: stewart.graham@beaumont.edu LA - English DB - MTMT ER - TY - JOUR AU - Nakae, Takuro AU - Matsumoto, Riki AU - Kunieda, Takeharu AU - Arakawa, Yoshiki AU - Kobayashi, Katsuya AU - Shimotake, Akihiro AU - Yamao, Yukihiro AU - Kikuchi, Takayuki AU - Aso, Toshihiko AU - Matsuhashi, Masao AU - Yoshida, Kazumichi AU - Ikeda, Akio AU - Takahashi, Ryosuke AU - Ralph, Matthew A. Lambon AU - Miyamoto, Susumu TI - Connectivity Gradient in the Human Left Inferior Frontal Gyrus: Intraoperative Cortico-Cortical Evoked Potential Study JF - CEREBRAL CORTEX J2 - CEREB CORTEX VL - 30 PY - 2020 IS - 8 SP - 4633 EP - 4650 PG - 18 SN - 1047-3211 DO - 10.1093/cercor/bhaa065 UR - https://m2.mtmt.hu/api/publication/31685308 ID - 31685308 N1 - Funding Agency and Grant Number: Ministry of Education, Culture, Sports, Science, and Technology [15H05874, 17H05907]; Japan Society for the Promotion of Science [17K10892, 18H02709, 18K19514, 19K17033, 19K18424]; Medical Research Council, UK [MR/R023883/1]; MRC [MR/R023883/1] Funding Source: UKRI Funding text: Ministry of Education, Culture, Sports, Science, and Technology (grant numbers 15H05874, 17H05907); Japan Society for the Promotion of Science (grant numbers 17K10892, 18H02709, 18K19514, 19K17033, 19K18424); Medical Research Council, UK (MR/R023883/1 to M.A.L.R.). AB - In the dual-stream model of language processing, the exact connectivity of the ventral stream to the anterior temporal lobe remains elusive. To investigate the connectivity between the inferior frontal gyrus (IFG) and the lateral part of the temporal and parietal lobes, we integrated spatiotemporal profiles of cortico-cortical evoked potentials (CCEPs) recorded intraoperatively in 14 patients who had undergone surgical resection for a brain tumor or epileptic focus. Four-dimensional visualization of the combined CCEP data showed that the pars opercularis (Broca's area) is connected to the posterior temporal cortices and the supramarginal gyrus, whereas the pars orbitalis is connected to the anterior lateral temporal cortices and angular gyrus. Quantitative topographical analysis of CCEP connectivity confirmed an anterior-posterior gradient of connectivity from IFG stimulus sites to the temporal response sites. Reciprocality analysis indicated that the anterior part of the IFG is bidirectionally connected to the temporal or parietal area. This study shows that each IFG subdivision has different connectivity to the temporal lobe with an anterior-posterior gradient and supports the classical connectivity concept of Dejerine; that is, the frontal lobe is connected to the temporal lobe through the arcuate fasciculus and also a double fan-shaped structure anchored at the limen insulae. LA - English DB - MTMT ER - TY - JOUR AU - Novitskaya, Y. AU - Dümpelmann, M. AU - Vlachos, A. AU - Reinacher, P.C. AU - Schulze-Bonhage, A. TI - In vivo-assessment of the human temporal network: Evidence for asymmetrical effective connectivity JF - NEUROIMAGE J2 - NEUROIMAGE VL - 214 PY - 2020 SN - 1053-8119 DO - 10.1016/j.neuroimage.2020.116769 UR - https://m2.mtmt.hu/api/publication/31295717 ID - 31295717 N1 - Epilepsy Center, Department of Neurosurgery, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, Freiburg, 79106, Germany Department of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, Albert Strasse 17, Freiburg, 79104, Germany Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, Freiburg, 79106, Germany Center for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, Freiburg, 79106, Germany Export Date: 30 April 2020 CODEN: NEIME Correspondence Address: Novitskaya, Y.; Epilepsy Center, Department of Neurosurgery, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, Germany; email: yuliya.novitskaya@gmail.com Funding details: Albert-Ludwigs-Universität Freiburg Funding text 1: This research was supported by the Human Brain Project (Grant: 650003 : Medical informatics platform for stereoelectroencephalography SEEGMIP). The article processing charge was funded by the University of Freiburg in the funding programme Open Access Publishing. LA - English DB - MTMT ER - TY - JOUR AU - Oane, I. AU - Barborica, A. AU - Chetan, F. AU - Donos, C. AU - Maliia, M.D. AU - Arbune, A.A. AU - Daneasa, A. AU - Pistol, C. AU - Nica, A.E. AU - Bajenaru, O.A. AU - Mindruta, I. TI - Cingulate cortex function and multi-modal connectivity mapped using intracranial stimulation JF - NEUROIMAGE J2 - NEUROIMAGE VL - 220 PY - 2020 SN - 1053-8119 DO - 10.1016/j.neuroimage.2020.117059 UR - https://m2.mtmt.hu/api/publication/31406146 ID - 31406146 N1 - Epilepsy Monitoring Unit, Neurology Department, Emergency University Hospital Bucharest, 169 Splaiul Independentei Street, Bucharest, Romania Neurology Department, Medical Faculty, Carol Davila University of Medicine and Pharmacy Bucharest, 8 Eroii Sanitari Boulevard 8, Bucharest, Romania Physics Department, University of Bucharest, 405 Atomistilor Street, Bucharest, Romania Intensive Care Unit Department, Emergency University Hospital Bucharest, 169 Splaiul Independentei Street, Bucharest, Romania Brain Research Group, Romanian Academy, 125 Calea Victoriei Street, Bucharest, Romania Export Date: 18 August 2020 CODEN: NEIME Correspondence Address: Barborica, A.; Physics Department, University of Bucharest, P.O. Box MG-11, Magurele, Romania; email: andrei.barborica@fizica.unibuc.ro Epilepsy Monitoring Unit, Neurology Department, Emergency University Hospital Bucharest, 169 Splaiul Independentei Street, Bucharest, Romania Neurology Department, Medical Faculty, Carol Davila University of Medicine and Pharmacy Bucharest, 8 Eroii Sanitari Boulevard 8, Bucharest, Romania Physics Department, University of Bucharest, 405 Atomistilor Street, Bucharest, Romania Intensive Care Unit Department, Emergency University Hospital Bucharest, 169 Splaiul Independentei Street, Bucharest, Romania Brain Research Group, Romanian Academy, 125 Calea Victoriei Street, Bucharest, Romania Export Date: 8 September 2020 CODEN: NEIME Correspondence Address: Barborica, A.; Physics Department, University of Bucharest, P.O. Box MG-11, Magurele, Romania; email: andrei.barborica@fizica.unibuc.ro LA - English DB - MTMT ER - TY - JOUR AU - Prime, D. AU - Woolfe, M. AU - O'Keefe, S. AU - Rowlands, D. AU - Dionisio, S. TI - Quantifying volume conducted potential using stimulation artefact in cortico-cortical evoked potentials JF - JOURNAL OF NEUROSCIENCE METHODS J2 - J NEUROSCI METH VL - 337 PY - 2020 SN - 0165-0270 DO - 10.1016/j.jneumeth.2020.108639 UR - https://m2.mtmt.hu/api/publication/31406150 ID - 31406150 N1 - Griffith University School of Engineering, Nathan, QLD, Australia Mater Advanced Epilepsy Unit, Brisbane, QLD, Australia Export Date: 18 August 2020 CODEN: JNMED Correspondence Address: Prime, D.; Advanced Epilepsy Unit, Level 8, Salmon Building, Mater Adult Hospital Brisbane, Australia; email: dave.prime@griffithuni.edu.au LA - English DB - MTMT ER - TY - JOUR AU - Silverstein, B.H. AU - Asano, E. AU - Sugiura, A. AU - Sonoda, M. AU - Lee, M.-H. AU - Jeong, J.-W. TI - Dynamic tractography: Integrating cortico-cortical evoked potentials and diffusion imaging JF - NEUROIMAGE J2 - NEUROIMAGE VL - 215 PY - 2020 SN - 1053-8119 DO - 10.1016/j.neuroimage.2020.116763 UR - https://m2.mtmt.hu/api/publication/31295716 ID - 31295716 N1 - Translational Neuroscience Program, Wayne State University, Detroit, MI, United States Dept. of Pediatrics, Wayne State University, Children's Hospital of Michigan, Detroit, MI, United States Dept. of Neurology, Wayne State University, Children's Hospital of Michigan, Detroit, MI, United States Translational Imaging Laboratory, Wayne State University, Detroit, MI, United States Export Date: 30 April 2020 CODEN: NEIME Correspondence Address: Jeong, J.-W.; Neurology and Translational Neuroscience Program Wayne State University School of Medicine Translational Imaging Laboratory, PET Center, Children's Hospital of Michigan 3901 Beaubien Street DetroitUnited States; email: jjeong@med.wayne.edu Funding details: National Institutes of Health, NIH, R01 NS089659, R01 NS064033 Funding text 1: This work was supported by grants from the National Institutes of Health ( R01 NS089659 to J.J. and R01 NS064033 to E.A.). LA - English DB - MTMT ER - TY - JOUR AU - Sugiura, A. AU - Silverstein, B.H. AU - Jeong, J.-W. AU - Nakai, Y. AU - Sonoda, M. AU - Motoi, H. AU - Asano, E. TI - Four-dimensional map of direct effective connectivity from posterior visual areas JF - NEUROIMAGE J2 - NEUROIMAGE VL - 210 PY - 2020 SN - 1053-8119 DO - 10.1016/j.neuroimage.2020.116548 UR - https://m2.mtmt.hu/api/publication/31406151 ID - 31406151 N1 - Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, United States Department of Neurology, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, United States Translational Neuroscience Program, Wayne State University, Detroit, MI 48201, United States Department of Neurological Surgery, Wakayama Medical University, Wakayama-shi, 6418509, Japan Cited By :1 Export Date: 18 August 2020 CODEN: NEIME Correspondence Address: Asano, E.; Department of Neurodiagnostics, Children's Hospital of Michigan, Wayne State University, Detroit Medical Center. 3901 Beaubien St., United States; email: easano@med.wayne.edu LA - English DB - MTMT ER - TY - JOUR AU - Usami, K. TI - Does single stimulus elucidate the complex mystery of sleep? JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 131 PY - 2020 IS - 2 SP - 463 EP - 464 PG - 2 SN - 1388-2457 DO - 10.1016/j.clinph.2019.11.010 UR - https://m2.mtmt.hu/api/publication/31138680 ID - 31138680 N1 - Export Date: 23 January 2020 CODEN: CNEUF Correspondence Address: Usami, K.; Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Japan; email: ukiyo@kuhp.kyoto-u.ac.jp Export Date: 30 April 2020 CODEN: CNEUF Correspondence Address: Usami, K.; Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Japan; email: ukiyo@kuhp.kyoto-u.ac.jp Funding details: Japan Society for the Promotion of Science, JSPS, KAKENHI 19K21210 Funding details: Eisai Funding details: Nihon Medi-Physics, NMP Funding details: Kanagawa University, KU Funding details: Otsuka Pharmaceutical, OPC Funding text 1: I thank Prof. Riki Matsumoto (the Department of Neurology, Kobe University, Japan) for his insightful input. This work is supported by JSPS KAKENHI 19K21210 to KU. Funding text 2: The Department of Epilepsy, Movement Disorders and Physiology, which KU belongs to, is an Industry-Academia Collaboration Course supported by a grant from Eisai Company, NIHON KOHDEN CORPORATION, Otsuka Pharmaceutical Co., and UCB Japan Co., Ltd. Export Date: 18 August 2020 CODEN: CNEUF Correspondence Address: Usami, K.; Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Japan; email: ukiyo@kuhp.kyoto-u.ac.jp Export Date: 8 September 2020 CODEN: CNEUF Correspondence Address: Usami, K.; Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Japan; email: ukiyo@kuhp.kyoto-u.ac.jp LA - English DB - MTMT ER - TY - JOUR AU - Crowther, Lawrence J. AU - Brunner, Peter AU - Kapeller, Christoph AU - Guger, Christoph AU - Kamada, Kyousuke AU - Bunch, Marjorie E. AU - Frawley, Bridget K. AU - Lynch, Timothy M. AU - Ritaccio, Anthony L. AU - Schalk, Gerwin TI - A quantitative method for evaluating cortical responses to electrical stimulation JF - JOURNAL OF NEUROSCIENCE METHODS J2 - J NEUROSCI METH VL - 311 PY - 2019 SP - 67 EP - 75 PG - 9 SN - 0165-0270 DO - 10.1016/j.jneumeth.2018.09.034 UR - https://m2.mtmt.hu/api/publication/30388857 ID - 30388857 N1 - National Center for Adaptive Neurotechnologies, Wadsworth Center, New York State Department of Health, Albany, NY, United States Department of Neurology, Albany Medical College, Albany, NY, United States g.tec Guger Technologies OG, Graz, Austria Department of Neurosurgery, Asahikawa Medical University, Asahikawa, Japan Department of Biomedical Sciences, State University of New York at Albany, Albany, NY, United States Department of Neurology, Mayo Clinic, Jacksonville, FL, United States Cited By :8 Export Date: 18 August 2020 CODEN: JNMED Correspondence Address: Schalk, G.; National Center for Adaptive Neurotechnologies, Wadsworth Center, New York State Department of HealthUnited States; email: gschalk@neurotechcenter.org AB - Background: Electrical stimulation of the cortex using subdurally implanted electrodes can causally reveal structural connectivity by eliciting cortico-cortical evoked potentials (CCEPs). While many studies have demonstrated the potential value of CCEPs, the methods to evaluate them were often relatively subjective, did not consider potential artifacts, and did not lend themselves to systematic scientific investigations. LA - English DB - MTMT ER - TY - JOUR AU - Hebbink, Jurgen AU - van Blooijs, Dorien AU - Huiskamp, Geertjan AU - Leijten, Frans S. S. AU - van Gils, Stephan A. AU - Meijer, Hil G. E. TI - A Comparison of Evoked and Non-evoked Functional Networks JF - BRAIN TOPOGRAPHY J2 - BRAIN TOPOGR VL - 32 PY - 2019 IS - 3 SP - 405 EP - 417 PG - 13 SN - 0896-0267 DO - 10.1007/s10548-018-0692-1 UR - https://m2.mtmt.hu/api/publication/31021978 ID - 31021978 N1 - Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, Netherlands Department of Applied Mathematics, MIRA Institute for Biomedical Engineering and Technical Medicine, University of Twente, Drienerlolaan 5, Enschede, 7500 AE, Netherlands Cited By :7 Export Date: 18 August 2020 CODEN: BRTOE Correspondence Address: Hebbink, J.; Department of Applied Mathematics, MIRA Institute for Biomedical Engineering and Technical Medicine, University of Twente, Drienerlolaan 5, Netherlands; email: g.j.hebbink@utwente.nl AB - The growing interest in brain networks to study the brain's function in cognition and diseases has produced an increase in methods to extract these networks. Typically, each method yields a different network. Therefore, one may ask what the resulting networks represent. To address this issue we consider electrocorticography (ECoG) data where we compare three methods. We derive networks from on-going ECoG data using two traditional methods: cross-correlation (CC) and Granger causality (GC). Next, connectivity is probed actively using single pulse electrical stimulation (SPES). We compare the overlap in connectivity between these three methods as well as their ability to reveal well-known anatomical connections in the language circuit. We find that strong connections in the CC network form more or less a subset of the SPES network. GC and SPES are related more weakly, although GC connections coincide more frequently with SPES connections compared to non-existing SPES connections. Connectivity between the two major hubs in the language circuit, Broca's and Wernicke's area, is only found in SPES networks. Our results are of interest for the use of patient-specific networks obtained from ECoG. In epilepsy research, such networks form the basis for methods that predict the effect of epilepsy surgery. For this application SPES networks are interesting as they disclose more physiological connections compared to CC and GC networks. LA - English DB - MTMT ER - TY - JOUR AU - Huang, Yuhao AU - Hajnal, Boglárka Zsófia AU - Entz, László AU - Fabó, Dániel AU - Herrero, Jose L. AU - Mehta, Ashesh D. AU - Keller, Corey J. TI - Intracortical Dynamics Underlying Repetitive Stimulation Predicts Changes in Network Connectivity JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 39 PY - 2019 IS - 31 SP - 6122 EP - 6135 PG - 14 SN - 0270-6474 DO - 10.1523/JNEUROSCI.0535-19.2019 UR - https://m2.mtmt.hu/api/publication/31020318 ID - 31020318 N1 - Funding Agency and Grant Number: National Institute of Neurological Disorders and Stroke [F31NS080357-01, T32-GM007288]; Stanford Society of Physician Scholars Collaborative Research Fellowship; Alpha Omega Alpha Postgraduate Research Award; Hungarian National Research, Development, and Innovation Office [2017-1.2.1-NKP-2017-00002]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007288] Funding Source: NIH RePORTER Funding text: This work was supported by the National Institute of Neurological Disorders and Stroke (F31NS080357-01 and T32-GM007288), Stanford Society of Physician Scholars Collaborative Research Fellowship, and Alpha Omega Alpha Postgraduate Research Award to C.J.K., and by the Hungarian National Research, Development, and Innovation Office (2017-1.2.1-NKP-2017-00002) to D.F. We thank Maria Fini and Victor Du for help with data collection, Pierre Megevand and Erin Yeagle for help with technical considerations of the experimental design, and Wei Wu for comments on the paper. All authors discussed the data, analysis, and methods and contributed to the paper. The authors are enormously indebted to the patients who participated in this study, as well as the nursing and physician staff at North Shore University Hospital (Manhassat, NY) and the National Institute of Clinical Neurosciences (Budapest, Hungary). AB - Targeted stimulation can be used to modulate the activity of brain networks. Previously we demonstrated that direct electrical stimulation produces predictable poststimulation changes in brain excitability. However, understanding the neural dynamics during stimulation and its relationship to poststimulation effects is limited but critical for treatment optimization. Here, we applied 10 Hz direct electrical stimulation across several cortical regions in 14 human subjects (6 males) implanted with intracranial electrodes for seizure monitoring. The stimulation train was characterized by a consistent increase in high gamma (70 -170 Hz) power. Immediately post-train, low-frequency (1-8 Hz) power increased, resulting in an evoked response that was highly correlated with the neural response during stimulation. Using two measures of network connectivity, corticocortical evoked potentials (indexing effective connectivity), and theta coherence (indexing functional connectivity), we found a stronger response to stimulation in regions that were highly connected to the stimulation site. In these regions, repeated cycles of stimulation trains and rest progressively altered the stimulation response. Finally, after just 2 min (similar to 10%) of repetitive stimulation, we were able to predict poststimulation connectivity changes with high disc rim inability. Together, this work reveals a relationship between stimulation dynamics and poststimulation connectivity changes in humans. Thus, measuring neural activity during stimulation can inform future plasticity-inducing protocols. LA - English DB - MTMT ER - TY - JOUR AU - Kirihara, Takaaki AU - Luo, Zhongyue AU - Chow, Siu Yu A. AU - Misawa, Ryuji AU - Kawada, Jiro AU - Shibata, Shinsuke AU - Khoyratee, Farad AU - Vollette, Carole Anne AU - Volz, Valentine AU - Levi, Timothee AU - Fujii, Teruo AU - Ikeuchi, Yoshiho TI - A Human Induced Pluripotent Stem Cell-Derived Tissue Model of a Cerebral Tract Connecting Two Cortical Regions JF - ISCIENCE J2 - ISCIENCE VL - 14 PY - 2019 SP - 301 EP - + PG - 22 SN - 2589-0042 DO - 10.1016/j.isci.2019.03.012 UR - https://m2.mtmt.hu/api/publication/31025419 ID - 31025419 N1 - Institute of Industrial Science, The University of Tokyo, Tokyo, Japan Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo, Japan Laboratoire de l'Intégration du Matériau au Système (IMS), University Bordeaux, Bordeaux INP, CNRS, UMR 5218, Talence, France Electron Microscope Laboratory, Keio University School of Medicine, Tokyo, Japan Cited By :3 Export Date: 18 August 2020 Correspondence Address: Ikeuchi, Y.; Institute of Industrial Science, The University of TokyoJapan; email: yikeuchi@iis.u-tokyo.ac.jp AB - Cerebral tracts connect separated regions within a brain and serve as fundamental structures that support integrative brain functions. However, understanding the mechanisms of cerebral tract development, macro-circuit formation, and related disorders has been hampered by the lack of an in vitro model. Here, we developed a human stem cell-derived model of cerebral tracts, which is composed of two spheroids of cortical neurons and a robust fascicle of axons linking these spheroids reciprocally. In a microdevice, two spheroids of cerebral neurons extended axons into a microchannel between the spheroids and spontaneously formed an axon fascicle, mimicking a cerebral tract. We found that the formation of axon fascicle was significantly promoted when two spheroids extended axons toward each other compared with axons extended from only one spheroid. The two spheroids were able to communicate electrically through the axon fascicle. This model tissue could facilitate studies of cerebral tract development and diseases. LA - English DB - MTMT ER - TY - JOUR AU - Lehner, Kurt R. AU - Yeagle, Erin M. AU - Argyelan, Miklos AU - Klimaj, Zoltan AU - Du, Victor AU - Megevand, Pierre AU - Hwang, Sean T. AU - Mehta, Ashesh D. TI - Validation of corpus callosotomy after laser interstitial thermal therapy: a multimodal approach JF - JOURNAL OF NEUROSURGERY J2 - J NEUROSURG VL - 131 PY - 2019 IS - 4 SP - 1095 EP - 1105 PG - 11 SN - 0022-3085 DO - 10.3171/2018.4.JNS172588 UR - https://m2.mtmt.hu/api/publication/31021974 ID - 31021974 N1 - Department of Neurosurgery, Hofstra Northwell School of Medicine, United States Feinstein Institute for Medical Research, United States Department of Neurology, North Shore University Hospital, Manhasset, NY, United States Cited By :5 Export Date: 18 August 2020 CODEN: JONSA Correspondence Address: Mehta, A.D.; Hofstra Northwell School of Medicine, Feinstein Institute for Medical ResearchUnited States; email: amehta@northwell.edu AB - OBJECTIVE Disconnection of the cerebral hemispheres by corpus callosotomy (CC) is an established means to palliate refractory generalized epilepsy. Laser interstitial thermal therapy (LITT) is gaining acceptance as a minimally invasive approach to treating epilepsy, but this method has not been evaluated in clinical series using established methodologies to assess connectivity. The goal in this study was to demonstrate the safety and feasibility of MRI-guided LITT for CC and to assess disconnection by using electrophysiology- and imaging-based methods.METHODS Retrospective chart and imaging review was performed in 5 patients undergoing LITT callosotomy at a single center. Diffusion tensor imaging and resting functional MRI were performed in all patients to assess anatomical and functional connectivity. In 3 patients undergoing simultaneous intracranial electroencephalography monitoring, corticocortical evoked potentials and resting electrocorticography were used to assess electrophysiological correlates.RESULTS All patients had generalized or multifocal seizure onsets. Three patients with preoperative evidence for possible lateralization underwent stereoelectroencephalography depth electrode implantation during the perioperative period. LITT ablation of the anterior corpus callosum was completed in a single procedure in 4 patients. One complication involving misplaced devices required a second procedure. Adequacy of the anterior callosotomy was confirmed using contrast-enhanced MRI and diffusion tensor imaging. Resting functional MRI, corticocortical evoked potentials, and resting electrocorticography demonstrated functional disconnection of the hemispheres. Postcallosotomy monitoring revealed lateralization of the seizures in all 3 patients with preoperatively suspected occult lateralization. Four of 5 patients experienced > 80% reduction in generalized seizure frequency. Two patients undergoing subsequent focal resection are free of clinical seizures at 2 years. One patient developed a 9-mm intraparenchymal hematoma at the site of entry and continued to have seizures after the procedure.CONCLUSIONS MRI-guided LITT provides an effective minimally invasive alternative method for CC in the treatment of seizures associated with drop attacks, bilaterally synchronous onset, and rapid secondary generalization. The disconnection is confirmed using anatomical and functional neuroimaging and electrophysiological measures. LA - English DB - MTMT ER - TY - JOUR AU - Usami, Kiyohide AU - Milsap, Griffin W. AU - Korzeniewska, Anna AU - Collard, Maxwell J. AU - Wang, Yujing AU - Lesser, Ronald P. AU - Anderson, William S. AU - Crone, Nathan E. TI - Cortical Responses to Input From Distant Areas are Modulated by Local Spontaneous Alpha/Beta Oscillations JF - CEREBRAL CORTEX J2 - CEREB CORTEX VL - 29 PY - 2019 IS - 2 SP - 777 EP - 787 PG - 11 SN - 1047-3211 DO - 10.1093/cercor/bhx361 UR - https://m2.mtmt.hu/api/publication/31021981 ID - 31021981 N1 - Department of Neurology, Johns Hopkins University, School of Medicine, 600N. Wolfe St., Baltimore, MD 21287, United States Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, United States Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, United States Department of Neurosurgery, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, United States Cited By :4 Export Date: 18 August 2020 CODEN: CECOE Correspondence Address: Crone, N.E.; Department of Neurology, Johns Hopkins University, School of Medicine, 600N. Wolfe St., United States; email: ncrone@jhmi.edu AB - Any given area in human cortex may receive input from multiple, functionally heterogeneous areas, potentially representing different processing threads. Alpha (8-13 Hz) and beta oscillations (13-20 Hz) have been hypothesized by other investigators to gate local cortical processing, but their influence on cortical responses to input from other cortical areas is unknown. To study this, we measured the effect of local oscillatory power and phase on cortical responses elicited by single-pulse electrical stimulation (SPES) at distant cortical sites, in awake human subjects implanted with intracranial electrodes for epilepsy surgery. In 4 out of 5 subjects, the amplitudes of corticocortical evoked potentials (CCEPs) elicited by distant SPES were reproducibly modulated by the power, but not the phase, of local oscillations in alpha and beta frequencies. Specifically, CCEP amplitudes were higher when average oscillatory power just before distant SPES (-110 to -10 ms) was high. This effect was observed in only a subset (0-33%) of sites with CCEPs and, like the CCEPs themselves, varied with stimulation at different distant sites. Our results suggest that although alpha and beta oscillations may gate local processing, they may also enhance the responsiveness of cortex to input from distant cortical sites. LA - English DB - MTMT ER - TY - JOUR AU - Usami, Kiyohide AU - Korzeniewska, Anna AU - Matsumoto, Riki AU - Kobayashi, Katsuya AU - Hitomi, Takefumi AU - Matsuhashi, Masao AU - Kunieda, Takeharu AU - Mikuni, Nobuhiro AU - Kikuchi, Takayuki AU - Yoshida, Kazumichi AU - Miyamoto, Susumu AU - Takahashi, Ryosuke AU - Ikeda, Akio AU - Crone, Nathan E. TI - The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation JF - SLEEP J2 - SLEEP VL - 42 PY - 2019 IS - 6 PG - 9 SN - 0161-8105 DO - 10.1093/sleep/zsz050 UR - https://m2.mtmt.hu/api/publication/31021975 ID - 31021975 N1 - Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States Department of Neurology, Kyoto University, Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan Department of Clinical Laboratory Medicine, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto, Japan Department of Respiratory Care and Sleep Control Medicine, Kyoto University, Graduate School of Medicine, Sakyoku, Kyoto, Japan Research and Educational Unit of Leaders for Integrated Medical System, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto, Japan Human Brain Research Center, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto, Japan Department of Neurosurgery, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto, Japan Department of Neurosurgery, Ehime University, Graduate School of Medicine, Shizukawa Toon city, Ehime, Japan Department of Neurosurgery, Sapporo Medical University, Chuo-ku, Sapporo, Japan Department of Epilepsy, Movement Disorders and Physiology, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto, Japan Cited By :5 Export Date: 18 August 2020 CODEN: SLEED Correspondence Address: Usami, K.; Department of Neurology, Kyoto University, Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Japan; email: ukiyo@kuhp.kyoto-u.ac.jp AB - Wakefulness and sleep arise from global changes in brain physiology that may also govern the flow of neural activity between cortical regions responsible for perceptual processing versus planning and action. To test whether and how the sleep/wake cycle affects the overall propagation of neural activity in large-scale brain networks, we applied single-pulse electrical stimulation (SPES) in patients implanted with intracranial EEG electrodes for epilepsy surgery. SPES elicited cortico-cortical spectral responses at high-gamma frequencies (CCSRHG, 80-150 Hz), which indexes changes in neuronal population firing rates. Using event-related causality (ERC) analysis, we found that the overall patterns of neural propagation among sites with CCSRHG were different during wakefulness and different sleep stages. For example, stimulation of frontal lobe elicited greater propagation toward parietal lobe during slow-wave sleep than during wakefulness. During REM sleep, we observed a decrease in propagation within frontal lobe, and an increase in propagation within parietal lobe, elicited by frontal and parietal stimulation, respectively. These biases in the directionality of large-scale cortical network dynamics during REM sleep could potentially account for some of the unique experiential aspects of this sleep stage. Together these findings suggest that the regulation of conscious awareness and sleep is associated with differences in the balance of neural propagation across large-scale frontal-parietal networks. LA - English DB - MTMT ER - TY - JOUR AU - Wei, Wei AU - Li, Yuandong AU - Xie, Zhiying AU - Deegan, Anthony J. AU - Wang, Ruikang K. TI - Spatial and Temporal Heterogeneities of Capillary Hemodynamics and Its Functional Coupling During Neural Activation JF - IEEE TRANSACTIONS ON MEDICAL IMAGING J2 - IEEE T MED IMAGING VL - 38 PY - 2019 IS - 5 SP - 1295 EP - 1303 PG - 9 SN - 0278-0062 DO - 10.1109/TMI.2018.2883244 UR - https://m2.mtmt.hu/api/publication/31019262 ID - 31019262 N1 - Department of Bioengineering, University of Washington, Seattle, WA 98195, United States Department of Biology, University of Washington, Seattle, WA 98195, United States Cited By :2 Export Date: 18 August 2020 CODEN: ITMID Correspondence Address: Wang, R.K.; Department of Bioengineering, University of WashingtonUnited States; email: wangrk@uw.edu AB - The cerebral vascular system provides a means to meet the constant metabolic needs of neuronal activities in the brain. Within the cerebral capillary bed, the interactions of spatial and temporal hemodynamics play a deterministic role in oxygen diffusion, however, the progression of which remains unclear. Taking the advantages of high-spatiotemporal resolution of optical coherence tomography capillary velocimetry designed with the eigen-decomposition statistical analysis, we investigated intrinsic red blood cell (RBC) velocities and their spatiotemporal adjustment within the capillaries permeating mouse cerebral cortex during electrical stimulation of contralateral hind paw. We found that the mean capillary transit velocity (mCTV) is increased and its temporal fluctuation bandwidth (TFB) is broadened within hind-paw somatosensory cortex. In addition, the degree to which the mCTV is increased negatively correlates with resting state mCTV, and the degree to which the TFB is increased negatively correlates with both the resting state mCTV and the TFB. In order to confirm the changes are due to hemodynamic regulation, we performed angiographic analyses and found that the vessel density remains almost constant, suggesting the observed functional activation does not involve recruitment of reserved capillaries. To further differentiate the contributions of the mCTV and the TFB to the spatiotemporally coupled hemodynamics, changes in the mCTV and TBF of the capillary flow were modeled and investigated through a Monte Carlo simulation. The results suggest that neural activation evokes the spatial transit time homogenization within the capillary bed, which is regulated via both the heterogeneous acceleration of RBC flow and the heterogeneous increase of temporal RBC fluctuation, ensuring sufficient oxygenation during functional hyperemia. LA - English DB - MTMT ER - TY - JOUR AU - Yoshimoto, Tetsuyuki AU - Maruichi, Katsuhiko AU - Itoh, Yasuhiro AU - Takamiya, Soichiro AU - Kaneko, Tetsuya TI - Monitoring Corticocortical Evoked Potentials During Intracranial Vascular Surgery JF - WORLD NEUROSURGERY J2 - WORLD NEUROSURG VL - 122 PY - 2019 SP - E947 EP - E954 PG - 8 SN - 1878-8750 DO - 10.1016/j.wneu.2018.10.179 UR - https://m2.mtmt.hu/api/publication/30512872 ID - 30512872 N1 - Department of Neurosurgery, Kashiwaba Neurosurgical Hospital, Sapporo, Japan Department of Neurophysiology, Kashiwaba Neurosurgical Hospital, Sapporo, Japan Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo, Japan Export Date: 18 August 2020 Correspondence Address: Yoshimoto, T.; Department of Neurosurgery, Kashiwaba Neurosurgical HospitalJapan; email: yossikamer@me.com AB - BACKGROUND: Monitoring of corticocortical evoked potentials (CCEPs) during brain tumor surgery of patients under anesthesia was recently reported to be effective in assisting in preservation of speech function. The aim of this study was to investigate whether CCEPs can be reproducibly measured between the frontal and temporal lobes during standard intracranial vascular surgery under general anesthesia; whether dynamic changes in CCEPs caused by reduced focal cerebral blood flow can be measured; and whether CCEPs can be used to monitor speech function, particularly associated with the left side of the brain. LA - English DB - MTMT ER - TY - JOUR AU - Zhao, Cui AU - Liang, Ying AU - Li, Chunlin AU - Gao, Runshi AU - Wei, Jing AU - Zuo, Rui AU - Zhong, Yihua AU - Ren, Zhaohui AU - Geng, Xinling AU - Zhang, Guojun AU - Zhang, Xu TI - Localization of Epileptogenic Zone Based on Cortico-Cortical Evoked Potential (CCEP): A Feature Extraction and Graph Theory Approach JF - FRONTIERS IN NEUROINFORMATICS J2 - FRONT NEUROINFORM VL - 13 PY - 2019 PG - 9 SN - 1662-5196 DO - 10.3389/fninf.2019.00031 UR - https://m2.mtmt.hu/api/publication/31025416 ID - 31025416 N1 - Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing, China School of Biomedical Engineering, Capital Medical University, Beijing, China Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China Export Date: 18 August 2020 Correspondence Address: Zhang, X.; Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical UniversityChina; email: zhangxu@ccmu.edu.cn AB - Objective: Epilepsy is a chronic brain disease, which is prone to relapse and affects individuals of all ages worldwide, particularly the very young and elderly. Up to one-third of these patients are medically intractable and require resection surgery. However, the outcomes of epilepsy surgery rely upon the clear identification of epileptogenic zone (EZ). The combination of cortico-cortical evoked potential (CCEP) and electrocorticography (ECoG) provides an opportunity to observe the connectivity of human brain network and more comprehensive information that may help the clinicians localize the epileptogenic focus more precisely. However, there is no standard analysis method in the clinical application of CCEPs, especially for the quantitative analysis of abnormal connectivity of epileptic networks. The aim of this paper was to present an approach on the batch processing of CCEPs and provide information relating to the localization of EZ for clinical study.Methods: Eight medically intractable epilepsy patients were included in this study. Each patient was implanted with subdural grid electrodes and electrical stimulations were applied directly to their cortex to induce CCEPs. After signal preprocessing, we constructed three effective brain networks at different spatial scales for each patient, regarding the amplitudes of CCEPs as the connection weights. Graph theory was then applied to analyze the brain network topology of epileptic patients, and the topological metrics of EZ and non-EZ (NEZ) were compared.Results: The effective connectivity network reconstructed from CCEPs was asymmetric, both the number and the amplitudes of effective CCEPs decreased with increasing distance between stimulating and recording sites. Besides, the distribution of CCEP responses was associated with the locations of EZ which tended to have higher degree centrality (DC) and nodal shortest path length (NLP) than NEZ.Conclusion: Our results indicated that the brain networks of epileptics were asymmetric and mainly composed of short-distance connections. The DC and NLP were highly consistent to the distribution of the EZ, and these topological parameters have great potential to be readily applied to the clinical localization of the EZ. LA - English DB - MTMT ER - TY - JOUR AU - Bauer, Adam Q AU - Kraft, Andrew W AU - Baxter, Grant A AU - Wright, Patrick W AU - Reisman, Matthew D AU - Bice, Annie R AU - Park, Jasmine J AU - Bruchas, Michael R AU - Snyder, Abraham Z AU - Lee, Jin-Moo AU - Culver, Joseph P TI - Effective Connectivity Measured Using Optogenetically Evoked Hemodynamic Signals Exhibits Topography Distinct from Resting State Functional Connectivity in the Mouse JF - CEREBRAL CORTEX J2 - CEREB CORTEX VL - 28 PY - 2018 IS - 1 SP - 370 EP - 386 PG - 17 SN - 1047-3211 DO - 10.1093/cercor/bhx298 UR - https://m2.mtmt.hu/api/publication/27302984 ID - 27302984 N1 - Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, United States Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, United States Department of Biomedical Engineering, Washington University School of Medicine, Saint Louis, MO 63110, United States Department of Physics, Washington University School of Medicine, Saint Louis, MO 63110, United States Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO 63110, United States Department of Neuroscience, Washington University School of Medicine, Saint Louis, MO 63110, United States Washington University School of Medicine, Scott McKinley Research Building, 4515 McKinley Ave, Saint Louis, MO 63110, United States Cited By :13 Export Date: 18 August 2020 CODEN: CECOE Correspondence Address: Bauer, A.Q.; Department of Radiology, Washington University School of MedicineUnited States; email: aqbauer@wustl.edu LA - English DB - MTMT ER - TY - JOUR AU - Fox, Kieran C R AU - Foster, Brett L AU - Kucyi, Aaron AU - Daitch, Amy L AU - Parvizi, Josef TI - Intracranial Electrophysiology of the Human Default Network JF - TRENDS IN COGNITIVE SCIENCES J2 - TRENDS COGN SCI VL - 22 PY - 2018 IS - 4 SP - 307 EP - 324 PG - 18 SN - 1364-6613 DO - 10.1016/j.tics.2018.02.002 UR - https://m2.mtmt.hu/api/publication/27302990 ID - 27302990 N1 - Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States Stanford Human Intracranial Cognitive Electrophysiology Program (SHICEP), Stanford, CA, United States Departments of Neurosurgery and Neuroscience, Baylor College of Medicine, Houston, TX, United States Stanford University School of Medicine, Stanford University, Stanford, CA, United States Cited By :21 Export Date: 18 August 2020 CODEN: TCSCF Correspondence Address: Fox, K.C.R.; Stanford Human Intracranial Cognitive Electrophysiology Program (SHICEP)United States; email: kcrfox@stanford.edu LA - English DB - MTMT ER - TY - JOUR AU - Keller, Corey J AU - Huang, Yuhao AU - Herrero, Jose L AU - Fini, Maria E AU - Du, Victor AU - Lado, Fred A AU - Honey, Christopher J AU - Mehta, Ashesh D TI - Induction and Quantification of Excitability Changes in Human Cortical Networks JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 38 PY - 2018 IS - 23 SP - S384 EP - S398 PG - 15 SN - 0270-6474 DO - 10.1523/JNEUROSCI.1088-17.2018 UR - https://m2.mtmt.hu/api/publication/27555163 ID - 27555163 N1 - Department of Neurosurgery, Feinstein Institute for Medical Research, Manhasset, NY 11030, United States Department of Neurology, Hofstra Northwell School of Medicine, Feinstein Institute for Medical Research, Manhasset, NY 11030, United States Department of Psychiatry and Behavioral Sciences, Stanford, CA 94305, United States Stanford Neuroscience Institute, Stanford University, Stanford, CA 94305, United States Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA 94394, United States Departments of Neuroscience and Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, United States Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, United States Cited By :14 Export Date: 18 August 2020 CODEN: JNRSD Correspondence Address: Keller, C.J.; Stanford University, 401 Quarry Road, United States; email: ckeller1@stanford.edu LA - English DB - MTMT ER - TY - JOUR AU - Lennartz, C AU - Schiefer, J AU - Rotter, S AU - Hennig, J AU - LeVan, P TI - Sparse estimation of resting-state effective connectivity from fMRI cross-spectra JF - FRONTIERS IN NEUROSCIENCE J2 - FRONT NEUROSCI-SWITZ VL - 12 PY - 2018 IS - MAY SN - 1662-4548 DO - 10.3389/fnins.2018.00287 UR - https://m2.mtmt.hu/api/publication/27416490 ID - 27416490 N1 - Department of Radiology, Medical Physics, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg, Germany Bernstein Center Freiburg and Faculty of Biology, University of Freiburg, Freiburg, Germany Cited By :2 Export Date: 18 August 2020 Correspondence Address: Lennartz, C.; Department of Radiology, Medical Physics, Medical Center, University of Freiburg, Faculty of Medicine, University of FreiburgGermany; email: carolin.lennartz@uniklinik-freiburg.de LA - English DB - MTMT ER - TY - JOUR AU - Parker, CS AU - Clayden, JD AU - Cardoso, MJ AU - Rodionov, R AU - Duncan, JS AU - Scott, C AU - Diehl, B AU - Ourselin, S TI - Structural and effective connectivity in focal epilepsy JF - NEUROIMAGE-CLINICAL J2 - NEUROIMAGE-CLIN VL - 17 PY - 2018 SP - 943 EP - 952 PG - 10 SN - 2213-1582 DO - 10.1016/j.nicl.2017.12.020 UR - https://m2.mtmt.hu/api/publication/27051926 ID - 27051926 N1 - Translational Imaging Group, Centre for Medical Image Computing, University College London, London, United Kingdom Developmental Imaging and Biophysics Unit, UCL Great Ormond Street Institute of Child Health, London, United Kingdom UCL Institute of Neurology, Department of Clinical and Experimental Epilepsy, Department of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom Cited By :11 Export Date: 18 August 2020 Correspondence Address: Parker, C.S.; Translational Imaging Group, Centre for Medical Image Computing, University College LondonUnited Kingdom; email: christopher.parker.10@ucl.ac.uk LA - English DB - MTMT ER - TY - JOUR AU - Trebaul, Lena AU - Deman, Pierre AU - Tuyisenge, Viateur AU - Jedynak, Maciej AU - Hugues, Etienne AU - Rudrauf, David AU - Bhattacharjee, Manik AU - Tadel, Francois AU - Chanteloup-Foret, Blandine AU - Saubat, Carole AU - Mejia, Gina Catalina Reyes AU - Adam, Claude AU - Nica, Anca AU - Pail, Martin AU - Dubeau, Francois AU - Rheims, Sylvain AU - Trebuchon, Agnes AU - Wang, Haixiang AU - Liu, Sinclair AU - Blauwblomme, Thomas AU - Garces, Mercedes AU - De Palma, Luca AU - Valentin, Antonio AU - Metsahonkala, Eeva-Liisa AU - Petrescu, Ana Maria AU - Landre, Elizabeth AU - Szurhaj, William AU - Hirsch, Edouard AU - Valton, Luc AU - Rocamora, Rodrigo AU - Schulze-Bonhage, Andreas AU - Mindruta, Ioana AU - Francione, Stefano AU - Maillard, Louis AU - Taussig, Delphine AU - Kahane, Philippe AU - David, Olivier TI - Probabilistic functional tractography of the human cortex revisited JF - NEUROIMAGE J2 - NEUROIMAGE VL - 181 PY - 2018 SP - 414 EP - 429 PG - 16 SN - 1053-8119 DO - 10.1016/j.neuroimage.2018.07.039 UR - https://m2.mtmt.hu/api/publication/30387610 ID - 30387610 N1 - Inserm, U1216, Grenoble, F-38000, France Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, F-38000, France Epilepsy Unit, Dept of Neurology, Pitié-Salpêtrière Hospital, APHP, Paris, France Neurology Department, CHU, Rennes, France Brno Epilepsy Center, Department of Neurology, St. Anne's University Hospital and Medical Faculty of Masaryk University, Brno, Czech Republic Montreal Neurological Institute and Hospital, Montreal, Canada Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and University of Lyon, Lyon, France Service de Neurophysiologie Clinique, APHM, Hôpitaux de la Timone, Marseille, France Yuquan Hospital Epilepsy Center, Tsinghua University, Beijing, China Canton Sanjiu Brain Hospital Epilepsy Center, Jinan University, Guangzhou, China Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, Université Paris V Descartes, Sorbonne Paris Cité, Paris, France Multidisciplinary Epilepsy Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain Department of Neuroscience, Bambino Gesù Children's Hospital, IRRCS, Rome, Italy Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), London, United Kingdom Epilepsy Unit, Hospital for Children and Adolescents, Helsinki, Finland Neurophysiology and Epilepsy Unit, Bicêtre Hospital, France Department of Neurosurgery, Sainte-Anne Hospital, Paris, France Epilepsy Unit, Department of Clinical Neurophysiology, Lille University Medical Center, Lille, France University Hospital, Department of Neurology, Strasbourg, France University Hospital, Department of Neurology, Toulouse, France Epilepsy Monitoring Unit, Department of Neurology, Hospital del Mar-IMIM, Barcelona, Spain Epilepsy Center, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany Neurology Department, University Emergency Hospital, Bucharest, Romania Epilepsy Surgery Center Niguarda Hospital, Milan, Italy Centre Hospitalier Universitaire de Nancy, Nancy, France Service de neurochirurgie pédiatrique, Fondation Rothschild, Paris, France CHU Grenoble Alpes, Neurology Department, Grenoble, France Cited By :16 Export Date: 18 August 2020 CODEN: NEIME Correspondence Address: David, O.; Grenoble Institut des Neurosciences, Chemin Fortuné Ferrini, Bât EJ Safra, France; email: Olivier.David@inserm.fr AB - In patients with pharmaco-resistant focal epilepsies investigated with intracranial electroencephalography (iEEG), direct electrical stimulations of a cortical region induce cortico-cortical evoked potentials (CCEP) in distant cerebral cortex, which properties can be used to infer large scale brain connectivity. In 2013, we proposed a new probabilistic functional tractography methodology to study human brain connectivity. We have now been revisiting this method in the F-TRACT project (f-tract.eu) by developing a large multicenter CCEP database of several thousand stimulation runs performed in several hundred patients, and associated processing tools to create a probabilistic atlas of human cortico-cortical connections. Here, we wish to present a snapshot of the methods and data of F-TRACT using a pool of 213 epilepsy patients, all studied by stereo-encephalography with intracerebral depth electrodes. The CCEPs were processed using an automated pipeline with the following consecutive steps: detection of each stimulation run from stimulation artifacts in raw intracranial EEG (iEEG) files, bad channels detection with a machine learning approach, model-based stimulation artifact correction, robust averaging over stimulation pulses. Effective connectivity between the stimulated and recording areas is then inferred from the properties of the first CCEP component, i.e. onset and peak latency, amplitude, duration and integral of the significant part. Finally, group statistics of CCEP features are implemented for each brain parcel explored by iEEG electrodes. The localization (coordinates, white/gray matter relative positioning) of electrode contacts were obtained from imaging data (anatomical MRI or CT scans before and after electrodes implantation). The iEEG contacts were repositioned in different brain parcellations from the segmentation of patients' anatomical MRI or from templates in the MNI coordinate system. The F-TRACT database using the first pool of 213 patients provided connectivity probability values for 95% of possible intrahemispheric and 56% of interhemispheric connections and CCEP features for 78% of intrahemisheric and 14% of interhemispheric connections. In this report, we show some examples of anatomo-functional connectivity matrices, and associated directional maps. We also indicate how CCEP features, especially latencies, are related to spatial distances, and allow estimating the velocity distribution of neuronal signals at a large scale. Finally, we describe the impact on the estimated connectivity of the stimulation charge and of the contact localization according to the white or gray matter. The most relevant maps for the scientific community are available for download on f-tract. eu (David et al., 2017) and will be regularly updated during the following months with the addition of more data in the F-TRACT database. This will provide an unprecedented knowledge on the dynamical properties of large fiber tracts in human. LA - English DB - MTMT ER - TY - JOUR AU - Waters, Allison C. AU - Veerakumar, Ashan AU - Choi, Ki Sueng AU - Howell, Bryan AU - Tiruvadi, Vineet AU - Bijanki, Kelly R. AU - Crowell, Andrea AU - Riva-Posse, Patricio AU - Mayberg, Helen S. TI - Test-retest reliability of a stimulation-locked evoked response to deep brain stimulation in subcallosal cingulate for treatment resistant depression JF - HUMAN BRAIN MAPPING J2 - HUM BRAIN MAPP VL - 39 PY - 2018 IS - 12 SP - 4844 EP - 4856 PG - 13 SN - 1065-9471 DO - 10.1002/hbm.24327 UR - https://m2.mtmt.hu/api/publication/30387613 ID - 30387613 N1 - Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, United States Cited By :5 Export Date: 18 August 2020 CODEN: HBMAE Correspondence Address: Waters, A.C.; Department of Psychiatry and Behavioral Sciences, Emory University School of MedicineUnited States; email: alliwaters@emory.edu AB - Deep brain stimulation (DBS) to the subcallosal cingulate cortex (SCC) is an emerging therapy for treatment resistant depression. Precision targeting of specific white matter fibers is now central to the model of SCC DBS treatment efficacy. A method to confirm SCC DBS target engagement is needed to reduce procedural variance across treatment providers and to optimize DBS parameters for individual patients. We examined the reliability of a novel cortical evoked response that is time-locked to a 2 Hz DBS pulse and shows the propagation of signal from the DBS target. The evoked response was detected in four individuals as a stereotyped series of components within 150 ms of a 6 V DBS pulse, each showing coherent topography on the head surface. Test-retest reliability across four repeated measures over 14 months met or exceeded standards for valid test construction in three of four patients. Several observations in this pilot sample demonstrate the prospective utility of this method to confirm surgical target engagement and instruct parameter selection. The topography of an orbital frontal component on the head surface showed specificity for patterns of forceps minor activation, which may provide a means to confirm DBS location with respect to key white matter structures. A divergent cortical response to unilateral stimulation of left (vs. right) hemisphere underscores the need for feedback acuity on the level of a single electrode, despite bilateral presentation of therapeutic stimulation. Results demonstrate viability of this method to explore patient-specific cortical responsivity to DBS for brain-circuit pathologies. LA - English DB - MTMT ER - TY - THES AU - Dombovári, Balázs Gábor TI - In vivo validation and software control of active intracortical microelectrodes PB - Pázmány Péter Katolikus Egyetem (PPKE) PY - 2017 SP - 93 DO - 10.15774/PPKE.ITK.2017.001 UR - https://m2.mtmt.hu/api/publication/3241331 ID - 3241331 N1 - Megjegyzés-26837091 PázmányPéterKatolikusEgyetem LA - English DB - MTMT ER - TY - CHAP AU - Donos, Cristian AU - Barborica, Andrei AU - Mindruta, Ioana AU - Maliia, Mihai AU - Popa, Irina AU - Ciurea, Jean ED - Opris, I ED - Casanova, M TI - Connectomics in Patients with Temporal Lobe Epilepsy T2 - THE PHYSICS OF THE MIND AND BRAIN DISORDERS PB - Springer Netherlands CY - Cham SN - 9783319296722 T3 - Springer Series in Cognitive and Neural Systems ; Vol. 11. PY - 2017 SP - 447 EP - 468 PG - 22 DO - 10.1007/978-3-319-29674-6_20 UR - https://m2.mtmt.hu/api/publication/31406154 ID - 31406154 LA - English DB - MTMT ER - TY - JOUR AU - Gkogkidis, C Alexis AU - Wang, Xi AU - Schubert, Tobias AU - Gierthmuehlen, Mortimer AU - Kohler, Fabian AU - Schulze-Bonhage, Andreas AU - Burgard, Wolfram AU - Rickert, Joern AU - Haberstroh, Joerg AU - Schuettler, Martin AU - Stieglitz, Thomas AU - Ball, Tonio TI - Closed-loop interaction with the cerebral cortex using a novel micro-ECoG-based implant: the impact of beta vs. gamma stimulation frequencies on corticocortical spectral responses JF - BRAIN-COMPUTER INTERFACES J2 - BRAIN-COMP INTERF VL - 4 PY - 2017 IS - 4 SP - 214 EP - 224 PG - 11 SN - 2326-263X DO - 10.1080/2326263X.2017.1381829 UR - https://m2.mtmt.hu/api/publication/27302995 ID - 27302995 N1 - Translational Neurotechnology Lab, Department of Neurosurgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering, Faculty of Engineering, University of Freiburg, Freiburg, Germany Department of Computer Science, Faculty of Engineering, University of Freiburg, Freiburg, Germany Department of Neurosurgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany CorTec GmbH, Freiburg, Germany Epilepsy Center, Department of Neurosurgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany CEMT, Experimental Surgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany Cited By :5 Export Date: 30 April 2020 Correspondence Address: Gkogkidis, C.A.; Translational Neurotechnology Lab, Department of Neurosurgery, Medical Center, Faculty of Medicine, University of FreiburgGermany; email: alexis.gkogkidis@uniklinik-freiburg.de Funding details: Deutsche Forschungsgemeinschaft, DFG, EXC1086 BrainLinks-BrainTools Funding details: Bundesministerium für Bildung und Forschung, BMBF, 13GW0053D MotorBic, 01GQ1510 OptiStim Funding text 1: This work was supported by the Deutsche Forschungsgemein-schaft, DFG [grant number EXC1086 BrainLinks-BrainTools]; German Federal Ministry of Education and Research, BMBF [grant number 13GW0053D MotorBic], [grant number 01GQ1510 OptiStim]. Translational Neurotechnology Lab, Department of Neurosurgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering, Faculty of Engineering, University of Freiburg, Freiburg, Germany Department of Computer Science, Faculty of Engineering, University of Freiburg, Freiburg, Germany Department of Neurosurgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany CorTec GmbH, Freiburg, Germany Epilepsy Center, Department of Neurosurgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany CEMT, Experimental Surgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany Cited By :5 Export Date: 18 August 2020 Correspondence Address: Gkogkidis, C.A.; Translational Neurotechnology Lab, Department of Neurosurgery, Medical Center, Faculty of Medicine, University of FreiburgGermany; email: alexis.gkogkidis@uniklinik-freiburg.de Translational Neurotechnology Lab, Department of Neurosurgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering, Faculty of Engineering, University of Freiburg, Freiburg, Germany Department of Computer Science, Faculty of Engineering, University of Freiburg, Freiburg, Germany Department of Neurosurgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany CorTec GmbH, Freiburg, Germany Epilepsy Center, Department of Neurosurgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany CEMT, Experimental Surgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany Cited By :6 Export Date: 19 January 2021 Correspondence Address: Gkogkidis, C.A.; Translational Neurotechnology Lab, Department of Neurosurgery, Medical Center, Faculty of Medicine, University of FreiburgGermany; email: alexis.gkogkidis@uniklinik-freiburg.de LA - English DB - MTMT ER - TY - JOUR AU - Keller, Corey J AU - Davidesco, Ido AU - Megevand, Pierre AU - Lado, Fred A AU - Malach, Rafael AU - Mehta, Ashesh D TI - Tuning Face Perception with Electrical Stimulation of the Fusiform Gyrus JF - HUMAN BRAIN MAPPING J2 - HUM BRAIN MAPP VL - 38 PY - 2017 IS - 6 SP - 2830 EP - 2842 PG - 13 SN - 1065-9471 DO - 10.1002/hbm.23543 UR - https://m2.mtmt.hu/api/publication/26741212 ID - 26741212 N1 - Cited By :7 Export Date: 30 April 2020 CODEN: HBMAE Correspondence Address: Mehta, A.D.; Department of Neurosurgery, Hofstra Northwell School of Medicine, and Feinstein Institute for Medical ResearchUnited States; email: amehta@northwell.edu Cited By :9 Export Date: 18 August 2020 CODEN: HBMAE Correspondence Address: Mehta, A.D.; Department of Neurosurgery, Hofstra Northwell School of Medicine, and Feinstein Institute for Medical ResearchUnited States; email: amehta@northwell.edu Cited By :10 Export Date: 19 January 2021 CODEN: HBMAE Correspondence Address: Mehta, A.D.; Department of Neurosurgery, Hofstra Northwell School of Medicine, and Feinstein Institute for Medical ResearchUnited States; email: amehta@northwell.edu LA - English DB - MTMT ER - TY - JOUR AU - Kobayashi, Katsuya AU - Matsumoto, Riki AU - Matsuhashi, Masao AU - Usami, Kiyohide AU - Shimotake, Akihiro AU - Kunieda, Takeharu AU - Kikuchi, Takayuki AU - Yoshida, Kazumichi AU - Mikuni, Nobuhiro AU - Miyamoto, Susumu AU - Fukuyama, Hidenao AU - Takahashi, Ryosuke AU - Ikeda, Akio TI - High frequency activity overriding cortico-cortical evoked potentials reflects altered excitability in the human epileptic focus JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 128 PY - 2017 IS - 9 SP - 1673 EP - 1681 PG - 9 SN - 1388-2457 DO - 10.1016/j.clinph.2017.06.249 UR - https://m2.mtmt.hu/api/publication/27277945 ID - 27277945 N1 - Department of Neurology, Kyoto University Graduate School of Medicine, 54, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan Human Brain Research Center, Kyoto University Graduate School of Medicine, 54, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, 54, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan Department of Neurosurgery, Ehime University Graduate School of Medicine, Shizukawa Toon CityEhime 791-0295, Japan Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan Department of Neurosurgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, 060-8543, Japan Cited By :5 Export Date: 30 April 2020 CODEN: CNEUF Correspondence Address: Matsumoto, R.; Department of Neurology, Kyoto University Graduate School of Medicine, 54, Shogoin-Kawaharacho, Sakyo-ku, Japan; email: matsumot@kuhp.kyoto-u.ac.jp Department of Neurology, Kyoto University Graduate School of Medicine, 54, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan Human Brain Research Center, Kyoto University Graduate School of Medicine, 54, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, 54, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan Department of Neurosurgery, Ehime University Graduate School of Medicine, Shizukawa Toon CityEhime 791-0295, Japan Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan Department of Neurosurgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, 060-8543, Japan Cited By :8 Export Date: 18 August 2020 CODEN: CNEUF Correspondence Address: Matsumoto, R.; Department of Neurology, Kyoto University Graduate School of Medicine, 54, Shogoin-Kawaharacho, Sakyo-ku, Japan; email: matsumot@kuhp.kyoto-u.ac.jp Department of Neurology, Kyoto University Graduate School of Medicine, 54, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan Human Brain Research Center, Kyoto University Graduate School of Medicine, 54, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, 54, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan Department of Neurosurgery, Ehime University Graduate School of Medicine, Shizukawa Toon CityEhime 791-0295, Japan Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan Department of Neurosurgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, 060-8543, Japan Cited By :9 Export Date: 19 January 2021 CODEN: CNEUF Correspondence Address: Matsumoto, R.; Department of Neurology, Kyoto University Graduate School of Medicine, 54, Shogoin-Kawaharacho, Sakyo-ku, Japan; email: matsumot@kuhp.kyoto-u.ac.jp LA - English DB - MTMT ER - TY - JOUR AU - Krieg, Julien AU - Koessler, Laurent AU - Jonas, Jacques AU - Colnat-Coulbois, Sophie AU - Vignal, Jean-Pierre AU - Benar, Christian G AU - Maillard, Louis G TI - Discrimination of a medial functional module within the temporal lobe using an effective connectivity model: A CCEP study JF - NEUROIMAGE J2 - NEUROIMAGE VL - 161 PY - 2017 SP - 219 EP - 231 PG - 13 SN - 1053-8119 DO - 10.1016/j.neuroimage.2017.07.061 UR - https://m2.mtmt.hu/api/publication/27072839 ID - 27072839 N1 - Université de Lorraine, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, Vandœuvre-lès-Nancy, 54500, France CNRS, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, Vandœuvre-lès-Nancy, 54500, France Service de Neurologie, Centre Hospitalier Universitaire de Nancy, 29 Avenue Du Maréchal de Lattre de Tassigny, Nancy, 54000, France Service de Neurochirurgie, Centre Hospitalier Universitaire de Nancy, 29 Avenue Du Maréchal de Lattre de Tassigny, Nancy, 54000, France Faculté de Médecine de Nancy, Université de Lorraine, 9 Avenue de La Forêt de Haye, Vandœuvre-lès-Nancy, 54500, France Université Catholique de Louvain, 10 Place Du Cardinal Mercier, Louvain-La-Neuve, 1348, Belgium Aix Marseille Université, Institut de Neurosciences des Systèmes, Marseille, F-13005, France INSERM, UMR 1106, Marseille, 13005, France Cited By :4 Export Date: 30 April 2020 CODEN: NEIME Correspondence Address: Krieg, J.; Université de Lorraine, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, France; email: julien.krieg@univ-lorraine.fr Université de Lorraine, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, Vandœuvre-lès-Nancy, 54500, France CNRS, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, Vandœuvre-lès-Nancy, 54500, France Service de Neurologie, Centre Hospitalier Universitaire de Nancy, 29 Avenue Du Maréchal de Lattre de Tassigny, Nancy, 54000, France Service de Neurochirurgie, Centre Hospitalier Universitaire de Nancy, 29 Avenue Du Maréchal de Lattre de Tassigny, Nancy, 54000, France Faculté de Médecine de Nancy, Université de Lorraine, 9 Avenue de La Forêt de Haye, Vandœuvre-lès-Nancy, 54500, France Université Catholique de Louvain, 10 Place Du Cardinal Mercier, Louvain-La-Neuve, 1348, Belgium Aix Marseille Université, Institut de Neurosciences des Systèmes, Marseille, F-13005, France INSERM, UMR 1106, Marseille, 13005, France Cited By :5 Export Date: 18 August 2020 CODEN: NEIME Correspondence Address: Krieg, J.; Université de Lorraine, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, France; email: julien.krieg@univ-lorraine.fr Université de Lorraine, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, Vandœuvre-lès-Nancy, 54500, France CNRS, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, Vandœuvre-lès-Nancy, 54500, France Service de Neurologie, Centre Hospitalier Universitaire de Nancy, 29 Avenue Du Maréchal de Lattre de Tassigny, Nancy, 54000, France Service de Neurochirurgie, Centre Hospitalier Universitaire de Nancy, 29 Avenue Du Maréchal de Lattre de Tassigny, Nancy, 54000, France Faculté de Médecine de Nancy, Université de Lorraine, 9 Avenue de La Forêt de Haye, Vandœuvre-lès-Nancy, 54500, France Université Catholique de Louvain, 10 Place Du Cardinal Mercier, Louvain-La-Neuve, 1348, Belgium Aix Marseille Université, Institut de Neurosciences des Systèmes, Marseille, F-13005, France INSERM, UMR 1106, Marseille, 13005, France Cited By :6 Export Date: 19 January 2021 CODEN: NEIME Correspondence Address: Krieg, J.; Université de Lorraine, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, France; email: julien.krieg@univ-lorraine.fr LA - English DB - MTMT ER - TY - JOUR AU - Matsumoto, Riki AU - Kunieda, Takeharu AU - Nair, Dileep TI - Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy JF - SEIZURE-EUROPEAN JOURNAL OF EPILEPSY J2 - SEIZURE-EUR J EPILEP VL - 44 PY - 2017 SP - 27 EP - 36 PG - 10 SN - 1059-1311 DO - 10.1016/j.seizure.2016.11.003 UR - https://m2.mtmt.hu/api/publication/27277950 ID - 27277950 N1 - Cited By :30 Export Date: 30 April 2020 CODEN: SEIZE Correspondence Address: Matsumoto, R.; Department of Neurology, Kyoto University Graduate School of MedicineJapan; email: matsumot@kuhp.kyoto-u.ac.jp Funding details: Kyoto University, R01NS089212 Funding details: Japan Epilepsy Research Foundation, JERF Funding details: National Institutes of Health, NIH Funding details: Ministry of Education, Culture, Sports, Science and Technology, MEXT Funding details: Ministry of Education, Culture, Sports, Science and Technology, MEXT Funding details: Cleveland Clinic Foundation, CCF, 15H01664, KAKENHI17790578, 23591273, 15H05874, 20591022, 26282218, 15K10361, 26560465 Funding details: National Institute of Neurological Disorders and Stroke, NINDS Funding text 1: The authors would like to thank Professors Hiroshi Shibasaki, Hans L?ders, and Akio Ikeda for their long-standing supports and advices for establishment of CCEP methodology. A series of CCEP studies have been partly supported by the Advanced International Clinical Fellowship Award from the Cleveland Clinic Foundation, KAKENHI17790578, 20591022, 23591273, 26282218, 26560465, 15H01664, 15H05874, 15K10361 from the Japan Ministry of Education, Culture, Sports, Science and Technology (MEXT), the Research Grants from the Japan Epilepsy Research Foundation, SPIRITS (Supporting Program for Interaction-based Initiative Team Studies) from Kyoto University, and R01NS089212 from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health. Cited By :36 Export Date: 18 August 2020 CODEN: SEIZE Correspondence Address: Matsumoto, R.; Department of Neurology, Kyoto University Graduate School of MedicineJapan; email: matsumot@kuhp.kyoto-u.ac.jp Cited By :44 Export Date: 19 January 2021 CODEN: SEIZE Correspondence Address: Matsumoto, R.; Department of Neurology, Kyoto University Graduate School of MedicineJapan; email: matsumot@kuhp.kyoto-u.ac.jp LA - English DB - MTMT ER - TY - JOUR AU - Mégevand, P AU - Groppe, DM AU - Bickel, S AU - Mercier, MR AU - Goldfinger, MS AU - Keller, CJ AU - Entz, László AU - Mehta, AD TI - The Hippocampus and Amygdala Are Integrators of Neocortical Influence: A CorticoCortical Evoked Potential Study JF - BRAIN CONNECTIVITY J2 - BRAIN CONNECT VL - 7 PY - 2017 IS - 10 SP - 648 EP - 660 PG - 13 SN - 2158-0014 DO - 10.1089/brain.2017.0527 UR - https://m2.mtmt.hu/api/publication/27052168 ID - 27052168 N1 - Funding Agency and Grant Number: Swiss National Science Foundation [P300P3_148388]; KTIA [NAP_13-1-20130001]; Page and Otto Marx Jr. Foundation; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007288] Funding Source: NIH RePORTER Funding text: We thank the patients for their participation and Willie Walker, Jr., the physicians, and other professionals of the Neurosurgery and Neurology departments of North Shore University Hospital for their assistance. We thank Michael D. Fox for helpful comments on the article. This work was supported by the Swiss National Science Foundation (grant P300P3_148388 to P.M.), KTIA (grant NAP_13-1-20130001 to L.E.), and the Page and Otto Marx Jr. Foundation. LA - English DB - MTMT ER - TY - JOUR AU - Shimada, Seijiro AU - Kunii, Naoto AU - Kawai, Kensuke AU - Matsuo, Takeshi AU - Ishishita, Yohei AU - Ibayashi, Kenji AU - Saito, Nobuhito TI - Impact of volume-conducted potential in interpretation of cortico-cortical evoked potential: Detailed analysis of high-resolution electrocorticography using two mathematical approaches JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 128 PY - 2017 IS - 4 SP - 549 EP - 557 PG - 9 SN - 1388-2457 DO - 10.1016/j.clinph.2017.01.012 UR - https://m2.mtmt.hu/api/publication/27277949 ID - 27277949 N1 - Department of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-kuTokyo 113-8655, Japan Department of Neurosurgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan Department of Neurosurgery, NTT Medical Center Tokyo, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo 141-8625, Japan Cited By :7 Export Date: 30 April 2020 CODEN: CNEUF Correspondence Address: Kunii, N.; Department of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Japan; email: nkunii-tky@umin.ac.jp Manufacturers: Unique Medical, Japan Funding details: Japan Society for the Promotion of Science, JSPS Funding text 1: This work was supported in part by Grant-in-Aid No. 26242040 for Scientific Research (A), No. 26462221 for Scientific Research (C), No. 16H06260 for Young Scientists (A), and No. 26861140 for Young Scientists (B) from the Japan Society for the Promotion of Science. Department of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-kuTokyo 113-8655, Japan Department of Neurosurgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan Department of Neurosurgery, NTT Medical Center Tokyo, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo 141-8625, Japan Cited By :7 Export Date: 18 August 2020 CODEN: CNEUF Correspondence Address: Kunii, N.; Department of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Japan; email: nkunii-tky@umin.ac.jp Department of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-kuTokyo 113-8655, Japan Department of Neurosurgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan Department of Neurosurgery, NTT Medical Center Tokyo, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo 141-8625, Japan Cited By :12 Export Date: 19 January 2021 CODEN: CNEUF Correspondence Address: Kunii, N.; Department of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Japan; email: nkunii-tky@umin.ac.jp LA - English DB - MTMT ER - TY - JOUR AU - Alagapan, Sankaraleengam AU - Schmidt, Stephen L AU - Lefebvre, Jeremie AU - Hadar, Eldad AU - Shin, Hae Won AU - Froehlich, Flavio TI - Modulation of Cortical Oscillations by Low-Frequency Direct Cortical Stimulation Is State-Dependent JF - PLOS BIOLOGY J2 - PLOS BIOL VL - 14 PY - 2016 IS - 3 PG - 21 SN - 1544-9173 DO - 10.1371/journal.pbio.1002424 UR - https://m2.mtmt.hu/api/publication/25830237 ID - 25830237 N1 - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Krembil Research Institute, University Health Network, Toronto, ON, Canada Department of Mathematics, University of Toronto, Toronto, ON, Canada Department of Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Neurobiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Cited By :57 Export Date: 18 August 2020 CODEN: PBLIB Correspondence Address: Frӧhlich, F.; Department of Psychiatry, University of North Carolina at Chapel HillUnited States; email: flavio_frohlich@med.unc.edu LA - English DB - MTMT ER - TY - JOUR AU - Boulogne, S AU - Ryvlin, P AU - Rheims, S TI - Single and paired-pulse electrical stimulation during invasive EEG recordings JF - REVUE NEUROLOGIQUE J2 - REV NEUROL-FRANCE VL - 172 PY - 2016 IS - 3 SP - 174 EP - 181 PG - 8 SN - 0035-3787 DO - 10.1016/j.neurol.2016.02.004 UR - https://m2.mtmt.hu/api/publication/26022699 ID - 26022699 N1 - Cited By :2 Export Date: 30 April 2020 CODEN: RENEA Correspondence Address: Rheims, S.; Lyon's Research Neuroscience Center, Inserm U1028/CNRS UMPR 5292, CH Le Vinatier, 95, boulevard Pinel, France; email: sylvain.rheims@univ-lyon1.fr Cited By :2 Export Date: 18 August 2020 CODEN: RENEA Correspondence Address: Rheims, S.; Lyon's Research Neuroscience Center, Inserm U1028/CNRS UMPR 5292, CH Le Vinatier, 95, boulevard Pinel, France; email: sylvain.rheims@univ-lyon1.fr Cited By :2 Export Date: 19 January 2021 CODEN: RENEA Correspondence Address: Rheims, S.; Lyon's Research Neuroscience Center, Inserm U1028/CNRS UMPR 5292, CH Le Vinatier, 95, boulevard Pinel, France; email: sylvain.rheims@univ-lyon1.fr LA - English DB - MTMT ER - TY - JOUR AU - Donos, Cristian AU - Maliia, Mihai Dragos AU - Mindruta, Ioana AU - Popa, Irina AU - Ene, Mirela AU - Balanescu, Bogdan AU - Ciurea, Ana AU - Barborica, Andrei TI - A connectomics approach combining structural and effective connectivity assessed by intracranial electrical stimulation JF - NEUROIMAGE J2 - NEUROIMAGE VL - 132 PY - 2016 SP - 344 EP - 358 PG - 15 SN - 1053-8119 DO - 10.1016/j.neuroimage.2016.02.054 UR - https://m2.mtmt.hu/api/publication/26022712 ID - 26022712 N1 - Physics Department, University of Bucharest, Bucharest, Romania Neurology Department, University Emergency Hospital, Bucharest, Romania Neurology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Neurosurgery Department, Bagdasar-Arseni Emergency Hospital, Bucharest, Romania Neurology and Neurovascular Diseases National Institute, Bucharest, Romania FHC Inc, Bowdoin, ME, United States Cited By :24 Export Date: 30 April 2020 CODEN: NEIME Correspondence Address: Barborica, A.; Physics Department, Bucharest University, Electricity, Solid State and Biophysics Section, P.O. Box MG-11, Romania; email: andrei.barborica@fizica.unibuc.ro Funding details: Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii, UEFISCDI, PN-II-ID-PCE-2011-3-0240 Funding text 1: We would like to thank Jean Ciurea, MD, Alin Rasina, MD, for their contribution to the surgical procedures. This work was supported by Romanian Government UEFISCDI research grant PN-II-ID-PCE-2011-3-0240 . Ana Ciurea received support through POSDRU/159/1.5/S/133652 . Physics Department, University of Bucharest, Bucharest, Romania Neurology Department, University Emergency Hospital, Bucharest, Romania Neurology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Neurosurgery Department, Bagdasar-Arseni Emergency Hospital, Bucharest, Romania Neurology and Neurovascular Diseases National Institute, Bucharest, Romania FHC Inc, Bowdoin, ME, United States Cited By :26 Export Date: 18 August 2020 CODEN: NEIME Correspondence Address: Barborica, A.; Physics Department, Bucharest University, Electricity, Solid State and Biophysics Section, P.O. Box MG-11, Romania; email: andrei.barborica@fizica.unibuc.ro Physics Department, University of Bucharest, Bucharest, Romania Neurology Department, University Emergency Hospital, Bucharest, Romania Neurology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Neurosurgery Department, Bagdasar-Arseni Emergency Hospital, Bucharest, Romania Neurology and Neurovascular Diseases National Institute, Bucharest, Romania FHC Inc, Bowdoin, ME, United States Cited By :27 Export Date: 19 January 2021 CODEN: NEIME Correspondence Address: Barborica, A.; Physics Department, Bucharest University, Electricity, Solid State and Biophysics Section, P.O. Box MG-11, Romania; email: andrei.barborica@fizica.unibuc.ro LA - English DB - MTMT ER - TY - JOUR AU - Tamura, Yukie AU - Ogawa, Hiroshi AU - Kapeller, Christoph AU - Prueckl, Robert AU - Takeuchi, Fumiya AU - Anei, Ryogo AU - Ritaccio, Anthony AU - Guger, Christoph AU - Kamada, Kyousuke TI - Passive language mapping combining real-time oscillation analysis with cortico-cortical evoked potentials for awake craniotomy JF - JOURNAL OF NEUROSURGERY J2 - J NEUROSURG VL - 125 PY - 2016 IS - 6 SP - 1580 EP - 1588 PG - 9 SN - 0022-3085 DO - 10.3171/2015.4.JNS15193 UR - https://m2.mtmt.hu/api/publication/27278320 ID - 27278320 N1 - Department of Neurosurgery, Asahikawa Medical University, 2-1, Midorigaoka-Higashi, Asahikawa, Hokkaido, 078-8510, Japan Guger Technologies OG, Graz, Austria Center for Advanced Research and Education, School of Medicine, Asahikawa Medical University, Hokkaido, Japan Department of Neurology, Albany Medical Center, Albany, NY, United States Cited By :25 Export Date: 30 April 2020 CODEN: JONSA Correspondence Address: Kamada, K.; Department of Neurosurgery, Asahikawa Medical University, 2-1, Midorigaoka-Higashi, Japan; email: kamady-k@umin.ac.jp Funding details: European Commission, EC, 269356 Funding details: Ministry of Education, Culture, Sports, Science and Technology, MEXT Funding details: Japan Society for the Promotion of Science, JSPS, 15H01657 Funding details: Ministry of Education, Culture, Sports, Science and Technology, MEXT Funding details: Seventh Framework Programme, FP7, 257695 Funding text 1: This work was supported in part by a Grant-in-Aid for Scientific Research (B) No. 24390337 (2012-2015) and a Grant-in-Aid for Exploratory Research No. 26670633 (2014-2016) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and JSPS KAKENHI Grant Number 15H01657, as well as the European Union FP7 Integrated Project VERE No. 257695 and the EU project "High Profile" No. 269356. Department of Neurosurgery, Asahikawa Medical University, 2-1, Midorigaoka-Higashi, Asahikawa, Hokkaido, 078-8510, Japan Guger Technologies OG, Graz, Austria Center for Advanced Research and Education, School of Medicine, Asahikawa Medical University, Hokkaido, Japan Department of Neurology, Albany Medical Center, Albany, NY, United States Cited By :26 Export Date: 18 August 2020 CODEN: JONSA Correspondence Address: Kamada, K.; Department of Neurosurgery, Asahikawa Medical University, 2-1, Midorigaoka-Higashi, Japan; email: kamady-k@umin.ac.jp Department of Neurosurgery, Asahikawa Medical University, 2-1, Midorigaoka-Higashi, Asahikawa, Hokkaido, 078-8510, Japan Guger Technologies OG, Graz, Austria Center for Advanced Research and Education, School of Medicine, Asahikawa Medical University, Hokkaido, Japan Department of Neurology, Albany Medical Center, Albany, NY, United States Cited By :30 Export Date: 19 January 2021 CODEN: JONSA Correspondence Address: Kamada, K.; Department of Neurosurgery, Asahikawa Medical University, 2-1, Midorigaoka-Higashi, Japan; email: kamady-k@umin.ac.jp LA - English DB - MTMT ER - TY - THES AU - Tóth, Emília TI - Development of multimodal diagnostic tools for epilepsy patients implanted with intracranial micro-and macroelectrodes PY - 2016 SP - 112 UR - https://m2.mtmt.hu/api/publication/26421929 ID - 26421929 N1 - PázmányPéterKatolikusEgyetem Megjegyzés-26833503 PBPázmányPéterKatolikusEgyetem Megjegyzés-26421872 Pázmány Péter Katolikus Egyetem LA - English DB - MTMT ER - TY - JOUR AU - Trebaul, Lena AU - Rudrauf, David AU - Job, Anne-Sophie AU - Maliia, Mihai Dragos AU - Popa, Irina AU - Barborica, Andrei AU - Minotti, Lorella AU - Mindruta, Ioana AU - Kahane, Philippe AU - David, Olivier TI - Stimulation artifact correction method for estimation of early cortico-cortical evoked potentials JF - JOURNAL OF NEUROSCIENCE METHODS J2 - J NEUROSCI METH VL - 264 PY - 2016 SP - 94 EP - 102 PG - 9 SN - 0165-0270 DO - 10.1016/j.jneumeth.2016.03.002 UR - https://m2.mtmt.hu/api/publication/26022698 ID - 26022698 N1 - Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, F-38000, France Inserm, U1216, Grenoble, F-38000, France Laboratoire de Neurophysiopathologie de l'Epilepsie, Centre Hospitalier Universitaire Grenoble-Alpes, Grenoble, France Neurology Department, University Emergency Hospital, Bucharest, Romania Physics Department, University of Bucharest, Bucharest, Romania FHC Inc, Bowdoin, ME, United States Neurology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Cited By :13 Export Date: 30 April 2020 CODEN: JNMED Correspondence Address: David, O.; Grenoble Institut des Neurosciences, Chemin Fortuné Ferrini, Bât EJ Safra, CHU Grenoble-AlpesFrance; email: Olivier.David@inserm.fr Funding details: Seventh Framework Programme, FP7, FP/2007-2013 Funding details: European Research Council, ERC Funding details: Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii, UEFISCDI, PN-II-ID-PCE-2011-3-0240 Funding details: DRCI 1325 Funding details: European Research Council, ERC, 616268 F-TRACT Funding text 1: The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme ( FP/2007-2013 )/ ERC Grant Agreement no. 616268 F-TRACT . This work was also funded by Romanian UEFISCDI Grant PN-II-ID-PCE-2011-3-0240 , and by a Grenoble-Alpes University Hospital grant ( DRCI 1325 , EPISTIM study). Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, F-38000, France Inserm, U1216, Grenoble, F-38000, France Laboratoire de Neurophysiopathologie de l'Epilepsie, Centre Hospitalier Universitaire Grenoble-Alpes, Grenoble, France Neurology Department, University Emergency Hospital, Bucharest, Romania Physics Department, University of Bucharest, Bucharest, Romania FHC Inc, Bowdoin, ME, United States Neurology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Cited By :15 Export Date: 18 August 2020 CODEN: JNMED Correspondence Address: David, O.; Grenoble Institut des Neurosciences, Chemin Fortuné Ferrini, Bât EJ Safra, CHU Grenoble-AlpesFrance; email: Olivier.David@inserm.fr Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, F-38000, France Inserm, U1216, Grenoble, F-38000, France Laboratoire de Neurophysiopathologie de l'Epilepsie, Centre Hospitalier Universitaire Grenoble-Alpes, Grenoble, France Neurology Department, University Emergency Hospital, Bucharest, Romania Physics Department, University of Bucharest, Bucharest, Romania FHC Inc, Bowdoin, ME, United States Neurology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Cited By :15 Export Date: 19 January 2021 CODEN: JNMED Correspondence Address: David, O.; Grenoble Institut des Neurosciences, Chemin Fortuné Ferrini, Bât EJ Safra, CHU Grenoble-AlpesFrance; email: Olivier.David@inserm.fr LA - English DB - MTMT ER - TY - JOUR AU - Yamao, Y AU - Kunieda, T AU - Matsumoto, R TI - Probing functional brain networks with cortical electrical stimulation JF - JAPANESE JOURNAL OF NEUROSURGERY J2 - JAPANESE JOURNAL OF NEUROSURGERY VL - 25 PY - 2016 IS - 5 SP - 411 EP - 420 PG - 10 SN - 0917-950X DO - 10.7887/jcns.25.411 UR - https://m2.mtmt.hu/api/publication/27305090 ID - 27305090 N1 - Export Date: 30 April 2020 CODEN: JJNEE Correspondence Address: Matsumoto, R.; Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Japan Export Date: 18 August 2020 CODEN: JJNEE Correspondence Address: Matsumoto, R.; Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Japan Export Date: 19 January 2021 CODEN: JJNEE Correspondence Address: Matsumoto, R.; Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Japan LA - Japanese DB - MTMT ER - TY - CHAP AU - Alexopoulos, A.V. AU - Jones, S.E. ED - Elaine, Wyllie ED - Barry, E Gidal TI - Focal motor seizures T2 - Wyllie's Treatment of Epilepsy: Principles and Practice: Sixth Edition PB - Wolters Kluwer Health CY - Philadelphia (PA) SN - 9781496300546 PY - 2015 SP - n EP - a UR - https://m2.mtmt.hu/api/publication/31295718 ID - 31295718 N1 - Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States Cleveland Clinic Lerner College of Medicine, Cleveland, OH, United States Imaging and Neurological Institutes, Cleveland Clinic, Cleveland, OH, United States Export Date: 30 April 2020 Correspondence Address: Alexopoulos, A.V.; Cleveland Clinic Lerner Research InstituteUnited States Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States Cleveland Clinic Lerner College of Medicine, Cleveland, OH, United States Imaging and Neurological Institutes, Cleveland Clinic, Cleveland, OH, United States Export Date: 19 January 2021 Correspondence Address: Alexopoulos, A.V.; Cleveland Clinic Lerner Research InstituteUnited States LA - English DB - MTMT ER - TY - THES AU - Entz, László TI - Mapping the human brain with cortical electrical stimulation PB - Semmelweis Egyetem PY - 2015 DO - 10.14753/SE.2015.1798 UR - https://m2.mtmt.hu/api/publication/3143095 ID - 3143095 LA - English DB - MTMT ER - TY - JOUR AU - Kobayashi, Katsuya AU - Matsumoto, Riki AU - Matsuhashi, Masao AU - Usami, Kiyohide AU - Shimotake, Akihiro AU - Kunieda, Takeharu AU - Kikuchi, Takayuki AU - Mikuni, Nobuhiro AU - Miyamoto, Susumu AU - Fukuyama, Hidenao AU - Takahashi, Ryosuke AU - Ikeda, Akio TI - Different Mode of Afferents Determines the Frequency Range of High Frequency Activities in the Human Brain: Direct Electrocorticographic Comparison between Peripheral Nerve and Direct Cortical Stimulation JF - PLOS ONE J2 - PLOS ONE VL - 10 PY - 2015 IS - 6 PG - 17 SN - 1932-6203 DO - 10.1371/journal.pone.0130461 UR - https://m2.mtmt.hu/api/publication/27277952 ID - 27277952 N1 - Department of Neurology, Kyoto University Graduate, School of Medicine, Kyoto, Japan Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate, School of Medicine, Kyoto, Japan Human Brain Research Center, Kyoto University Graduate, School of Medicine, Kyoto, Japan Department of Neurosurgery, Kyoto University Graduate, School of Medicine, Kyoto, Japan Department of Neurosurgery, Sapporo Medical University, School of Medicine, Sapporo, Hokkaido, Japan Cited By :7 Export Date: 30 April 2020 CODEN: POLNC Department of Neurology, Kyoto University Graduate, School of Medicine, Kyoto, Japan Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate, School of Medicine, Kyoto, Japan Human Brain Research Center, Kyoto University Graduate, School of Medicine, Kyoto, Japan Department of Neurosurgery, Kyoto University Graduate, School of Medicine, Kyoto, Japan Department of Neurosurgery, Sapporo Medical University, School of Medicine, Sapporo, Hokkaido, Japan Cited By :7 Export Date: 18 August 2020 CODEN: POLNC Department of Neurology, Kyoto University Graduate, School of Medicine, Kyoto, Japan Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate, School of Medicine, Kyoto, Japan Human Brain Research Center, Kyoto University Graduate, School of Medicine, Kyoto, Japan Department of Neurosurgery, Kyoto University Graduate, School of Medicine, Kyoto, Japan Department of Neurosurgery, Sapporo Medical University, School of Medicine, Sapporo, Hokkaido, Japan Cited By :7 Export Date: 19 January 2021 CODEN: POLNC LA - English DB - MTMT ER - TY - JOUR AU - Kunieda, Takeharu AU - Yamao, Yukihiro AU - Kikuchi, Takayuki AU - Matsumoto, Riki TI - New Approach for Exploring Cerebral Functional Connectivity: Review of Cortico-cortical Evoked Potential JF - NEUROLOGIA MEDICO-CHIRURGICA J2 - NEUROL MED-CHIR VL - 55 PY - 2015 IS - 5 SP - 374 EP - 382 PG - 9 SN - 0470-8105 DO - 10.2176/nmc.ra.2014-0388 UR - https://m2.mtmt.hu/api/publication/27277953 ID - 27277953 N1 - Departments of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan Departments of Epilepsy and Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan Cited By :17 Export Date: 30 April 2020 CODEN: NMCHB Correspondence Address: Kunieda, T.; Departments of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Shogoinkawahara-cho, Japan; email: kuny@kuhp.kyoto-u.ac.jp Departments of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan Departments of Epilepsy and Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan Cited By :21 Export Date: 18 August 2020 CODEN: NMCHB Correspondence Address: Kunieda, T.; Departments of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Shogoinkawahara-cho, Japan; email: kuny@kuhp.kyoto-u.ac.jp Departments of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan Departments of Epilepsy and Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan Cited By :23 Export Date: 19 January 2021 CODEN: NMCHB Correspondence Address: Kunieda, T.; Departments of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Shogoinkawahara-cho, Japan; email: kuny@kuhp.kyoto-u.ac.jp LA - English DB - MTMT ER - TY - THES AU - Lee, Steven T TI - Wireless tools for neuromodulation PY - 2015 SP - 184 UR - https://m2.mtmt.hu/api/publication/26837082 ID - 26837082 N1 - PurdueUniversity LA - English DB - MTMT ER - TY - JOUR AU - Yaffe, Robert B AU - Borger, Philip AU - Megevand, Pierre AU - Groppe, David M AU - Kramer, Mark A AU - Chu, Catherine J AU - Santaniello, Sabato AU - Meisel, Christian AU - Mehta, Ashesh D AU - Sarma, Sridevi V TI - Physiology of functional and effective networks in epilepsy JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 126 PY - 2015 IS - 2 SP - 227 EP - 236 PG - 10 SN - 1388-2457 DO - 10.1016/j.clinph.2014.09.009 UR - https://m2.mtmt.hu/api/publication/27277954 ID - 27277954 N1 - Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, United States Department of Neurosurgery, Hofstra North Shore-LIJ School of Medicine and Feinstein Institute for Medical Research, Manhasset, NY 11030, United States Department of Mathematics and Statistics, Boston University, Boston, MA 02215, United States Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, United States Harvard Medical School, Boston, MA 02115, United States National Institute of Mental Health, Bethesda, MD 20892, United States Cited By :49 Export Date: 18 August 2020 CODEN: CNEUF Correspondence Address: Yaffe, R.B.; Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Hackerman Hall, 3400 North Charles Street, United States Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, United States Department of Neurosurgery, Hofstra North Shore-LIJ School of Medicine and Feinstein Institute for Medical Research, Manhasset, NY 11030, United States Department of Mathematics and Statistics, Boston University, Boston, MA 02215, United States Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, United States Harvard Medical School, Boston, MA 02115, United States National Institute of Mental Health, Bethesda, MD 20892, United States Cited By :55 Export Date: 19 January 2021 CODEN: CNEUF Correspondence Address: Yaffe, R.B.; Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Hackerman Hall, 3400 North Charles Street, United States; email: yaffer@jhu.edu LA - English DB - MTMT ER - TY - JOUR AU - Keller, CJ AU - Honey, CJ AU - Mégevand, P AU - Entz, László AU - Ulbert, István AU - Mehta, AD TI - Mapping human brain networks with cortico-cortical evoked potentials JF - PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B - BIOLOGICAL SCIENCES J2 - PHILOS T ROY SOC B VL - 369 PY - 2014 IS - 1653 PG - 14 SN - 0962-8436 DO - 10.1098/rstb.2013.0528 UR - https://m2.mtmt.hu/api/publication/2736859 ID - 2736859 N1 - Megjegyzés-24592695 SU SI AB - The cerebral cortex forms a sheet of neurons organized into a network of interconnected modules that is highly expanded in humans and presumably enables our most refined sensory and cognitive abilities. The links of this network form a fundamental aspect of its organization, and a great deal of research is focusing on understanding how information flows within and between different regions. However, an often-overlooked element of this connectivity regards a causal, hierarchical structure of regions, whereby certain nodes of the cortical network may exert greater influence over the others. While this is difficult to ascertain non-invasively, patients undergoing invasive electrode monitoring for epilepsy provide a unique window into this aspect of cortical organization. In this review, we highlight the potential for corticocortical evoked potential (CCEP) mapping to directly measure neuronal propagation across large-scale brain networks with spatio-temporal resolution that is superior to traditional neuroimaging methods.We first introduce effective connectivity and discuss the mechanisms underlying CCEP generation. Next, we highlight how CCEP mapping has begun to provide insight into the neural basis of non-invasive imaging signals. Finally, we present a novel approach to perturbing and measuring brain network function during cognitive processing. The direct measurement of CCEPs in response to electrical stimulation represents a potentially powerful clinical and basic science tool for probing the large-scale networks of the human cerebral cortex. © 2014 The Author(s) Published by the Royal Society. All rights reserved. LA - English DB - MTMT ER -