@article{MTMT:34479998, title = {Electrode Development for Epilepsy Diagnosis and Treatment}, url = {https://m2.mtmt.hu/api/publication/34479998}, author = {Paulk, A.C. and Salami, P. and Zelmann, R. and Cash, S.S.}, doi = {10.1016/j.nec.2023.09.003}, journal-iso = {NEUROSURG CLIN N AM}, journal = {NEUROSURGERY CLINICS OF NORTH AMERICA}, volume = {35}, unique-id = {34479998}, issn = {1042-3680}, year = {2024}, eissn = {1558-1349}, pages = {135-149} } @article{MTMT:34539411, title = {Advances in Deep Brain Stimulation: From Mechanisms to Applications}, url = {https://m2.mtmt.hu/api/publication/34539411}, author = {Sandoval-Pistorius, S.S. and Hacker, M.L. and Waters, A.C. and Wang, J. and Provenza, N.R. and de, Hemptinne C. and Johnson, K.A. and Morrison, M.A. and Cernera, S.}, doi = {10.1523/JNEUROSCI.1427-23.2023}, journal-iso = {J NEUROSCI}, journal = {JOURNAL OF NEUROSCIENCE}, volume = {43}, unique-id = {34539411}, issn = {0270-6474}, year = {2023}, eissn = {1529-2401}, pages = {7575-7586} } @article{MTMT:34539410, title = {Microstimulation of human somatosensory cortex evokes task-dependent, spatially patterned responses in motor cortex}, url = {https://m2.mtmt.hu/api/publication/34539410}, author = {Shelchkova, N.D. and Downey, J.E. and Greenspon, C.M. and Okorokova, E.V. and Sobinov, A.R. and Verbaarschot, C. and He, Q. and Sponheim, C. and Tortolani, A.F. and Moore, D.D. and Kaufman, M.T. and Lee, R.C. and Satzer, D. and Gonzalez-Martinez, J. and Warnke, P.C. and Miller, L.E. and Boninger, M.L. and Gaunt, R.A. and Collinger, J.L. and Hatsopoulos, N.G. and Bensmaia, S.J.}, doi = {10.1038/s41467-023-43140-2}, journal-iso = {NAT COMMUN}, journal = {NATURE COMMUNICATIONS}, volume = {14}, unique-id = {34539410}, issn = {2041-1723}, year = {2023}, eissn = {2041-1723} } @article{MTMT:33229863, title = {Naming impairments evoked by focal cortical electrical stimulation in the ventral temporal cortex correlate with increased functional connectivity}, url = {https://m2.mtmt.hu/api/publication/33229863}, author = {Aron, Olivier and Krieg, Julien and Brissart, Helene and Abdallah, Chifaou and Colnat-Coulbois, Sophie and Jonas, Jacques and Maillard, Louis}, doi = {10.1016/j.neucli.2022.06.002}, journal-iso = {NEUROPHYSIOL CLIN}, journal = {NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY}, volume = {52}, unique-id = {33229863}, issn = {0987-7053}, abstract = {Background: High-frequency cortical electrical stimulations (HF-CES) are the gold standard for presurgical functional mapping. In the dominant ventral temporal cortex (VTC) HF-CES can elicit transient naming impairment (eloquent sites), defining a basal temporal language area (BTLA).Objective: Whether naming impairments induced by HF-CES within the VTC are related to a spe-cific pattern of connectivity of the BTLA within the temporal lobe remains unknown. We addressed this issue by comparing the connectivity of eloquent and non-eloquent sites from the VTC using cortico-cortical evoked potentials (CCEP).Methods: Low frequency cortical electrical stimulations (LF-CES) were used to evoke CCEP in nine individual brains explored with Stereo-Electroencephalography. We compared the connec-tivity of eloquent versus non eloquent sites within the VTC using Pearson's correlation matrix.Results: Overall, within the VTC, eloquent sites were associated with increased functional con-nectivity compared to non-eloquent sites. Among the VTC structures, this pattern holds true for the inferior temporal gyrus and the parahippocampal gyrus while the fusiform gyrus specifically showed a high connectivity in both non eloquent and eloquent sites.Conclusions: Our findings suggest that the cognitive effects of focal HF-CES are related to the functional connectivity properties of the stimulated sites, and therefore to the disturbance of a wide cortical network. They further suggest that functional specialization of a cortical region emerges from its specific pattern of functional connectivity. Cortical electrical stimulation func-tional mapping protocols including LF coupled to HF-CES could provide valuable data character-izing both local and distant functional architecture.(c) 2022 The Authors. Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).}, keywords = {functional connectivity; fusiform gyrus; drug resistant epilepsy; Cortico-cortical evoked potentials; Basal temporal lan-guage area; Stereo-electro-encephalography}, year = {2022}, eissn = {1769-7131}, pages = {312-322}, orcid-numbers = {Aron, Olivier/0000-0003-2620-0951} } @article{MTMT:33006262, title = {The Referential Montage Inadequately Localizes Corticocortical Evoked Potentials in Stereoelectroencephalography}, url = {https://m2.mtmt.hu/api/publication/33006262}, author = {Dickey, Adam S. and Alwaki, Abdulrahman and Kheder, Ammar and Willie, Jon T. and Drane, Daniel L. and Pedersen, Nigel P.}, doi = {10.1097/WNP.0000000000000792}, journal-iso = {J CLIN NEUROPHYSIOL}, journal = {JOURNAL OF CLINICAL NEUROPHYSIOLOGY}, volume = {39}, unique-id = {33006262}, issn = {0736-0258}, abstract = {Purpose: Corticocortical evoked potentials (CCEPs) resulting from single pulse electrical stimulation are increasingly used to understand seizure networks, as well as normal brain connectivity. However, we observed that when using depth electrodes, traditional measures of CCEPs amplitude using a referential montage can be falsely localizing, often to white matter. Methods: We pooled 27 linear electrode arrays targeting the amygdala, hippocampus, or cingulate cortex from eight participants. Using postoperative imaging, we classified contacts as being in gray matter, white matter, or bordering each and measured the amplitude using the root-mean-squared deviation from baseline in a referential, common average, bipolar, or Laplacian montage. Results: Of 27 electrode contacts, 25 (93%) had a significantly higher mean amplitude when in gray matter than in white matter using a Laplacian montage, which was significantly more than the 12 of 27 electrodes (44%) when using a referential montage (P = 0.0003, Fisher exact test). The area under the curve for a receiver operating characteristic classifying contacts as gray or white matter was significantly higher for either the Laplacian (0.79) or the bipolar (0.72) montage when compared with either the common average (0.56) or the referential (0.51) montage (P <= 0.005, bootstrap). Conclusions: Both the Laplacian and bipolar montages were superior to the common average or referential montage in localizing CCEPs to gray matter. These montages may be more appropriate for interpreting CCEPs when using depth electrodes than the referential montage, which has typically been used in prior studies of CCEPs with subdural grids.}, keywords = {Stereoelectroencephalography; Brain connectivity; single pulse electrical stimulation; Corticocortical evoked potentials; Laplacian montage}, year = {2022}, eissn = {1537-1603}, pages = {412-418} } @article{MTMT:33167384, title = {Time-frequency signatures evoked by single-pulse deep brain stimulation to the subcallosal cingulate}, url = {https://m2.mtmt.hu/api/publication/33167384}, author = {Smith, Ezra E. and Choi, Ki Sueng and Veerakumar, Ashan and Obatusin, Mosadoluwa and Howell, Bryan and Smith, Andrew H. and Tiruvadi, Vineet and Crowell, Andrea L. and Riva-Posse, Patricio and Alagapan, Sankaraleengam and Rozell, Christopher J. and Mayberg, Helen S. and Waters, Allison C.}, doi = {10.3389/fnhum.2022.939258}, journal-iso = {FRONT HUM NEUROSCI}, journal = {FRONTIERS IN HUMAN NEUROSCIENCE}, volume = {16}, unique-id = {33167384}, issn = {1662-5161}, abstract = {Precision targeting of specific white matter bundles that traverse the subcallosal cingulate (SCC) has been linked to efficacy of deep brain stimulation (DBS) for treatment resistant depression (TRD). Methods to confirm optimal target engagement in this heterogenous region are now critical to establish an objective treatment protocol. As yet unexamined are the time-frequency features of the SCC evoked potential (SCC-EP), including spectral power and phase-clustering. We examined these spectral features-evoked power and phase clustering-in a sample of TRD patients (n = 8) with implanted SCC stimulators. Electroencephalogram (EEG) was recorded during wakeful rest. Location of electrical stimulation in the SCC target region was the experimental manipulation. EEG was analyzed at the surface level with an average reference for a cluster of frontal sensors and at a time window identified by prior study (50-150 ms). Morlet wavelets generated indices of evoked power and inter-trial phase clustering. Enhanced phase clustering at theta frequency (4-7 Hz) was observed in every subject and was significantly correlated with SCC-EP magnitude, but only during left SCC stimulation. Stimulation to dorsal SCC evinced stronger phase clustering than ventral SCC. There was a weak correlation between phase clustering and white matter density. An increase in evoked delta power (2-4 Hz) was also coincident with SCC-EP, but was less consistent across participants. DBS evoked time-frequency features index mm-scale changes to the location of stimulation in the SCC target region and correlate with structural characteristics implicated in treatment optimization. Results also imply a shared generative mechanism (inter-trial phase clustering) between evoked potentials evinced by electrical stimulation and evoked potentials evinced by auditory/visual stimuli and behavioral tasks. Understanding how current injection impacts downstream cortical activity is essential to building new technologies that adapt treatment parameters to individual differences in neurophysiology.}, keywords = {Deep brain stimulation; stimulation evoked potential; single pulse electrical stimulation; subcallosal cingulate; time frequency analyses; treatment resistant depression (TRD); inter-trial phase clustering; perturbation mapping}, year = {2022}, eissn = {1662-5161} } @article{MTMT:33229822, title = {Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential}, url = {https://m2.mtmt.hu/api/publication/33229822}, author = {Togo, Masaya and Matsumoto, Riki and Usami, Kiyohide and Kobayashi, Katsuya and Takeyama, Hirofumi and Nakae, Takuro and Shimotake, Akihiro and Kikuchi, Takayuki and Yoshida, Kazumichi and Matsuhashi, Masao and Kunieda, Takeharu and Miyamoto, Susumu and Takahashi, Ryosuke and Ikeda, Akio}, doi = {10.1016/j.neuroimage.2022.119639}, journal-iso = {NEUROIMAGE}, journal = {NEUROIMAGE}, volume = {263}, unique-id = {33229822}, issn = {1053-8119}, abstract = {The medial parietal cortices are components of the default mode network (DMN), which are active in the resting state. The medial parietal cortices include the precuneus and the dorsal posterior cingulate cortex (dPCC). Few studies have mentioned differences in the connectivity in the medial parietal cortices, and these differences have not yet been precisely elucidated. Electrophysiological connectivity is essential for understanding cortical function or functional differences. Since little is known about electrophysiological connections from the medial parietal cortices in humans, we evaluated distinct connectivity patterns in the medial parietal cortices by constructing a standardized connectivity map using cortico-cortical evoked potential (CCEP). This study included nine patients with partial epilepsy or a brain tumor who underwent chronic intracranial electrode placement covering the medial parietal cortices. Single-pulse electrical stimuli were delivered to the medial parietal cortices (38 pairs of electrodes). Responses were standardized using the z-score of the baseline activity, and a response density map was constructed in the Montreal Neurological Institutes (MNI) space. The precuneus tended to connect with the inferior parietal lobule (IPL), the occipital cortex, superior parietal lobule (SPL), and the dorsal premotor area (PMd) (the four most active regions, in descending order), while the dPCC tended to connect to the middle cingulate cortex, SPL, precuneus, and IPL. The connectivity pattern differs significantly between the precuneus and dPCC stimulation ( p < 0.05). Regarding each part of the medial parietal cortices, the distributions of parts of CCEP responses resembled those of the functional connectivity database. Based on how the dPCC was connected to the medial frontal area, SPL, and IPL, its connectivity pattern could not be explained by DMN alone, but suggested a mixture of DMN and the frontoparietal cognitive network. These findings improve our understanding of the connectivity profile within the medial parietal cortices. The electrophysiological connectivity is the basis of propagation of electrical activities in patients with epilepsy. In addition, it helps us to better understand the epileptic network arising from the medial parietal cortices.}, keywords = {default mode network; posterior cingulate cortex; Precuneus; Medial parietal cortices; Cortico-cortical evoked potential (CCEP)}, year = {2022}, eissn = {1095-9572}, orcid-numbers = {Usami, Kiyohide/0000-0003-2257-8279; Nakae, Takuro/0000-0002-3574-1744; Kikuchi, Takayuki/0000-0002-6295-5510; Yoshida, Kazumichi/0000-0002-8898-079X} } @article{MTMT:32277679, title = {Local and distant responses to single pulse electrical stimulation reflect different forms of connectivity}, url = {https://m2.mtmt.hu/api/publication/32277679}, author = {Crocker, Britni and Ostrowski, Lauren and Williams, Ziv M. and Dougherty, Darin D. and Eskandar, Emad N. and Widge, Alik S. and Chu, Catherine J. and Cash, Sydney S. and Paulk, Angelique C.}, doi = {10.1016/j.neuroimage.2021.118094}, journal-iso = {NEUROIMAGE}, journal = {NEUROIMAGE}, volume = {237}, unique-id = {32277679}, issn = {1053-8119}, abstract = {Measuring connectivity in the human brain involves innumerable approaches using both noninvasive (fMRI, EEG) and invasive (intracranial EEG or iEEG) recording modalities, including the use of external probing stimuli, such as direct electrical stimulation. To examine how different measures of connectivity correlate with one another, we compared 'passive' measures of connectivity during resting state conditions to the more 'active' probing measures of connectivity with single pulse electrical stimulation (SPES). We measured the network engagement and spread of the cortico-cortico evoked potential (CCEP) induced by SPES at 53 out of 104 total sites across the brain, including cortical and subcortical regions, in patients with intractable epilepsy (N = 11) who were undergoing intracranial recordings as a part of their clinical care for identifying seizure onset zones. We compared the CCEP network to functional, effective, and structural measures of connectivity during a resting state in each patient. Functional and effective connectivity measures included correlation or Granger causality measures applied to stereoEEG (sEEGs) recordings. Structural connectivity was derived from diffusion tensor imaging (DTI) acquired before intracranial electrode implant and monitoring (N = 8). The CCEP network was most similar to the resting state voltage correlation network in channels near to the stimulation location. In contrast, the distant CCEP network was most similar to the DTI network. Other connectivity measures were not as similar to the CCEP network. These results demonstrate that different connectivity measures, including those derived from active stimulation-based probing, measure different, complementary aspects of regional interrelationships in the brain.}, keywords = {Connectivity; diffusion tensor imaging; Intracranial; SEEG; direct electrical stimulation}, year = {2021}, eissn = {1095-9572}, orcid-numbers = {Ostrowski, Lauren/0000-0002-8377-4751} } @article{MTMT:32277265, title = {Recording cortico-cortical evoked potentials of the human arcuate fasciculus under general anaesthesia}, url = {https://m2.mtmt.hu/api/publication/32277265}, author = {Giampiccolo, D. and Parmigiani, S. and Basaldella, F. and Russo, S. and Pigorini, A. and Rosanova, M. and Cattaneo, L. and Sala, F.}, doi = {10.1016/j.clinph.2021.03.044}, journal-iso = {CLIN NEUROPHYSIOL}, journal = {CLINICAL NEUROPHYSIOLOGY}, volume = {132}, unique-id = {32277265}, issn = {1388-2457}, abstract = {Objective: We examined the feasibility of using cortico-cortical evoked potentials (CCEPs) to monitor the major cortical white matter tract involved in language, the arcuate fasciculus (AF), during surgery under general anaesthesia.Methods: We prospectively recruited nine patients undergoing surgery for lesions in the left peri-sylvian cortex, for whom awake surgery was not indicated. High angular resolution diffusion imaging (HARDI) tractography was used to localise frontal and temporal AF terminations, which guided intraoperative cortical strip placement.Results: CCEPs were successfully evoked in 5/9 patients, showing a positive potential (P1) at 12 ms and a negative component (N1) at 21 ms when stimulating from the frontal lobe and recording in the temporal lobe. CCEP responses peaked in the posterior middle temporal gyrus. No CCEPs were evoked when stimulating temporal sites and recording from frontal contacts.Conclusion: For the first time, we show that CCEPs can be evoked from the peri-sylvian cortices also in adult patients who are not candidates for awake procedures. Our results are akin to those described in the awake setting and suggest the recorded activity is conveyed by the arcuate fasciculus.Significance: This intraoperative approach may have promising implications in reducing deficits in patients that require surgery in language areas under general anesthesia. (C) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.}, keywords = {LANGUAGE; neurosurgery; Intraoperative Neurophysiological Monitoring; Brain tumour; asleep surgery; CCEPs}, year = {2021}, eissn = {1872-8952}, pages = {1966-1973} } @article{MTMT:32277683, title = {Single-pulse electrical stimulation methodology in freely moving rat}, url = {https://m2.mtmt.hu/api/publication/32277683}, author = {Gronlier, Eloise and Vendramini, Estelle and Volle, Julien and Wozniak-Kwasniewska, Agata and Santos, Noelia Anton and Coizet, Veronique and Duveau, Venceslas and David, Olivier}, doi = {10.1016/j.jneumeth.2021.109092}, journal-iso = {J NEUROSCI METH}, journal = {JOURNAL OF NEUROSCIENCE METHODS}, volume = {353}, unique-id = {32277683}, issn = {0165-0270}, abstract = {Background: Cortico-cortical evoked potentials (CCEP) are becoming popular to infer brain connectivity and cortical excitability in implanted refractory epilepsy patients. Our goal was to transfer this methodology to the freely moving rodent.New method: CCEP were recorded on freely moving Sprague-Dawley rats, from cortical and subcortical areas using depth electrodes. Electrical stimulation was applied using 1 ms biphasic current pulse, cathodic first, at a frequency of 0.5 Hz, with intensities ranging from 0.2 to 0.8 mA. Data were then processed in a similar fashion to human clinical studies, which included epoch selection, artefact correction and smart averaging.Results: For a large range of tested intensities, we recorded CCEPs with very good signal to noise ratio and reproducibility between animals, without any behavioral modification. The CCEP were composed of different components according to recorded and stimulated sites, similarly to human recordings. Comparison with existing methods: We minimally adapted a clinically-motivated methodology to a freely moving rodent model to achieve high translational relevance of future preclinical studies.Conclusions: Our results indicate that the CCEP methodology can be applied to freely moving rodents and transferred to preclinical research. This will be of interest to address various neuroscientific questions, in physiological and pathological conditions.}, keywords = {rodent; local field potential (LFP); Cortico-cortical evoked potentials (CCEP); intracranial electroencephalography (iEEG); Direct electrical stimulation (DES)}, year = {2021}, eissn = {1872-678X}, orcid-numbers = {David, Olivier/0000-0003-0776-0216} } @article{MTMT:33006202, title = {Inducing neuroplasticity through intracranial theta-burst stimulation in the human sensorimotor cortex}, url = {https://m2.mtmt.hu/api/publication/33006202}, author = {Herrero, Jose L. and Smith, Alexander and Mishra, Akash and Markowitz, Noah and Mehta, Ashesh D. and Bickel, Stephan}, doi = {10.1152/jn.00320.2021}, journal-iso = {J NEUROPHYSIOL}, journal = {JOURNAL OF NEUROPHYSIOLOGY}, volume = {126}, unique-id = {33006202}, issn = {0022-3077}, abstract = {The progress of therapeutic neuromodulation greatly depends on improving stimulation parameters to most efficiently induce neuroplasticity effects. Intermittent theta-burst stimulation (iTBS), a form of electrical stimulation that mimics natural brain activity patterns, has proved to efficiently induce such effects in animal studies and rhythmic transcranial magnetic stimulation studies in humans. However, little is known about the potential neuroplasticity effects of iTBS applied through intracranial electrodes in humans. This study characterizes the physiological effects of intracranial iTBS in humans and compare them with alpha-frequency stimulation, another frequently used neuromodulatory pattern. We applied these two stimulation patterns to well-defined regions in the sensorimotor cortex, which elicited contralateral hand muscle contractions during clinical mapping, in patients with epilepsy implanted with intracranial electrodes. Treatment effects were evaluated using oscillatory coherence across areas connected to the treatment site, as defined with corticocortical-evoked potentials. Our results show that iTBS increases coherence in the beta-frequency band within the sensorimotor network indicating a potential neuroplasticity effect. The effect is specific to the sensorimotor system, the beta band, and the stimulation pattern and outlasted the stimulation period by similar to 3 min. The effect occurred in four out of seven subjects depending on the buildup of the effect during iTBS treatment and other patterns of oscillatory activity related to ceiling effects within the beta band and to preexistent coherence within the alpha band. By characterizing the neurophysiological effects of iTBS within well-defined cortical networks, we hope to provide an electrophysiological framework that allows clinicians/researchers to optimize brain stimulation protocols which may have translational value.NEW & NOTEWORTHY theta-Burst stimulation (TBS) protocols in transcranial magnetic stimulation studies have shown improved treatment efficacy in a variety of neuropsychiatric disorders. The optimal protocol to induce neuroplasticity in invasive direct electrical stimulation approaches is not known. We report that intracranial TBS applied in human sensorimotor cortex increases local coherence of preexistent beta rhythms. The effect is specific to the stimulation frequency and the stimulated network and outlasts the stimulation period by similar to 3 min.}, keywords = {Neuronal Plasticity; Intracranial EEG; Direct electrical brain stimulation; iTBS; beta oscillations in sensorimotor cortex}, year = {2021}, eissn = {1522-1598}, pages = {1723-1739}, orcid-numbers = {Markowitz, Noah/0000-0001-9826-575X} } @article{MTMT:32277682, title = {Cortico-cortical evoked potential by single-pulse electrical stimulation is a generally safe procedure}, url = {https://m2.mtmt.hu/api/publication/32277682}, author = {Kobayashi, Katsuya and Matsumoto, Riki and Usami, Kiyohide and Matsuhashi, Masao and Shimotake, Akihiro and Kikuchi, Takayuki and Yoshida, Kazumichi and Kunieda, Takeharu and Miyamoto, Susumu and Takahashi, Ryosuke and Ikeda, Akio}, doi = {10.1016/j.clinph.2020.12.022}, journal-iso = {CLIN NEUROPHYSIOL}, journal = {CLINICAL NEUROPHYSIOLOGY}, volume = {132}, unique-id = {32277682}, issn = {1388-2457}, abstract = {Objective: Cortico-cortical evoked potential (CCEP) by single-pulse electrical stimulation (SPES) is useful to investigate effective connectivity and cortical excitability. We aimed to clarify the safety of CCEPs.Methods: We retrospectively analyzed 29 consecutive patients with intractable partial epilepsy undergoing chronic subdural grid implantation and CCEP recording. Repetitive SPES (1 Hz) was systematically applied to a pair of adjacent electrodes over almost all electrodes. We evaluated the incidences of after discharges (ADs) and clinical seizures.Results: Out of 1283 electrode pairs, ADs and clinical seizures were observed in 12 and 5 pairs (0.94% and 0.39%, per electrode pair) in 7 and 3 patients (23.3% and 10.0%, per patient), respectively. Of the 18-82 pairs per patient, ADs and clinical seizures were induced in 0-4 and 0-3 pairs, respectively. Stimulating 4 SOZ (seizure onset zone) (2.5%) and 8 non-SOZ pairs (0.75%) resulted in ADs. We observed clinical seizures in stimulating 4 SOZ (2.5%) and 1 non-SOZ pair (0.09%). The incidence of clinical seizures varied significantly between SOZ and non-SOZ stimulations (p = 0.001), while the difference in AD incidence tended towards significance (p = 0.058).Conclusion: Although caution should be taken in stimulating SOZ, CCEP is a safe procedure for presurgical evaluation. Significance: CCEP is safe under the established protocol.(c) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.}, keywords = {Cortico-cortical evoked potential; afterdischarge; single-pulse electrical stimulation; Clinical seizure}, year = {2021}, eissn = {1872-8952}, pages = {1033-1040}, orcid-numbers = {Kikuchi, Takayuki/0000-0002-6295-5510; Yoshida, Kazumichi/0000-0002-8898-079X; Miyamoto, Susumu/0000-0002-3648-3572} } @article{MTMT:32277268, title = {Novel Asleep Techniques for Intraoperative Assessment of Brain Connectivity}, url = {https://m2.mtmt.hu/api/publication/32277268}, author = {Sala, Francesco and Giampiccolo, Davide and Cattaneo, Luigi}, doi = {10.3389/fneur.2021.687030}, journal-iso = {FRONT NEUR}, journal = {FRONTIERS IN NEUROLOGY}, volume = {12}, unique-id = {32277268}, issn = {1664-2295}, keywords = {Brain Mapping; Intraoperative Neurophysiological Monitoring; Neuro-oncology; surgical; Cortico-cortical evoked potentials; Motor evoked potentials}, year = {2021}, eissn = {1664-2295} } @article{MTMT:31406152, title = {Sleep modulates effective connectivity: A study using intracranial stimulation and recording}, url = {https://m2.mtmt.hu/api/publication/31406152}, author = {Arbune, A.A. and Popa, I. and Mindruta, I. and Beniczky, Sándor and Donos, C. and Daneasa, A. and Mălîia, M.D. and Băjenaru, O.A. and Ciurea, J. and Barborica, A.}, doi = {10.1016/j.clinph.2019.09.010}, journal-iso = {CLIN NEUROPHYSIOL}, journal = {CLINICAL NEUROPHYSIOLOGY}, volume = {131}, unique-id = {31406152}, issn = {1388-2457}, year = {2020}, eissn = {1872-8952}, pages = {529-541} } @{MTMT:34539414, title = {BRAIN MAPPING AND NEURO-MONITORING IN LOW GRADE GLIOMA SURGERY: CURRENT CHALLENGES AND FUTURE PERSPECTIVES}, url = {https://m2.mtmt.hu/api/publication/34539414}, author = {Brogna, C. and Pereira, N. and Ribas, E.C. and Jones, H. and Vergani, F. and Bassi, S. and Ashkan, K. and Bhangoo, R.}, booktitle = {Encyclopedia of Surgery: Volume 1: (22 Volume Set)}, volume = {1}, unique-id = {34539414}, year = {2020}, pages = {7097-7116} } @article{MTMT:30868010, title = {Reorganization of Large-Scale Functional Networks during Low-Frequency Electrical Stimulation of the Cortical Surface}, url = {https://m2.mtmt.hu/api/publication/30868010}, author = {File, Bálint and Nánási, Tibor and Tóth, E. and Bokodi, Virág and Tóth, Brigitta and Hajnal, Boglárka Zsófia and Balogh-Kardos, Zsófia Klára and Entz, László and Erőss, Loránd and Ulbert, István and Fabó, Dániel}, doi = {10.1142/S0129065719500229}, journal-iso = {INT J NEURAL SYST}, journal = {INTERNATIONAL JOURNAL OF NEURAL SYSTEMS}, volume = {30}, unique-id = {30868010}, issn = {0129-0657}, year = {2020}, eissn = {1793-6462}, orcid-numbers = {Erőss, Loránd/0000-0002-5796-5546; Ulbert, István/0000-0001-9941-9159; Fabó, Dániel/0000-0001-5141-5351} } @article{MTMT:31023490, title = {Pathological responses to single-pulse electrical stimuli in epilepsy: The role of feedforward inhibition}, url = {https://m2.mtmt.hu/api/publication/31023490}, author = {Hebbink, Jurgen and Huiskamp, Geertjan and van Gils, Stephan A. and Leijten, Frans S. S. and Meijer, Hil G. E.}, doi = {10.1111/ejn.14562}, journal-iso = {EUR J NEUROSCI}, journal = {EUROPEAN JOURNAL OF NEUROSCIENCE}, volume = {51}, unique-id = {31023490}, issn = {0953-816X}, abstract = {Delineation of epileptogenic cortex in focal epilepsy patients may profit from single-pulse electrical stimulation during intracranial EEG recordings. Single-pulse electrical stimulation evokes early and delayed responses. Early responses represent connectivity. Delayed responses are a biomarker for epileptogenic cortex, but up till now, the precise mechanism generating delayed responses remains elusive. We used a data-driven modelling approach to study early and delayed responses. We hypothesized that delayed responses represent indirect responses triggered by early response activity and investigated this for 11 patients. Using two coupled neural masses, we modelled early and delayed responses by combining simulations and bifurcation analysis. An important feature of the model is the inclusion of feedforward inhibitory connections. The waveform of early responses can be explained by feedforward inhibition. Delayed responses can be viewed as second-order responses in the early response network which appear when input to a neural mass falls below a threshold forcing it temporarily to a spiking state. The combination of the threshold with noisy background input explains the typical stochastic appearance of delayed responses. The intrinsic excitability of a neural mass and the strength of its input influence the probability at which delayed responses to occur. Our work gives a theoretical basis for the use of delayed responses as a biomarker for the epileptogenic zone, confirming earlier clinical observations. The combination of early responses revealing effective connectivity, and delayed responses showing intrinsic excitability, makes single-pulse electrical stimulation an interesting tool to obtain data for computational models of epilepsy surgery.}, keywords = {focal epilepsy; neural mass model; single-pulse electrical stimulation; delayed responses; early responses}, year = {2020}, eissn = {1460-9568}, pages = {1122-1136} } @article{MTMT:31406149, title = {The biochemical profile of post-mortem brain from people who suffered from epilepsy reveals novel insights into the etiopathogenesis of the disease}, url = {https://m2.mtmt.hu/api/publication/31406149}, author = {Lalwani, A.M. and Yilmaz, A. and Bisgin, H. and Ugur, Z. and Akyol, S. and Graham, S.F.}, doi = {10.3390/metabo10060261}, journal-iso = {METABOLITES}, journal = {METABOLITES}, volume = {10}, unique-id = {31406149}, issn = {2218-1989}, year = {2020}, eissn = {2218-1989}, pages = {1-16} } @article{MTMT:31685308, title = {Connectivity Gradient in the Human Left Inferior Frontal Gyrus: Intraoperative Cortico-Cortical Evoked Potential Study}, url = {https://m2.mtmt.hu/api/publication/31685308}, author = {Nakae, Takuro and Matsumoto, Riki and Kunieda, Takeharu and Arakawa, Yoshiki and Kobayashi, Katsuya and Shimotake, Akihiro and Yamao, Yukihiro and Kikuchi, Takayuki and Aso, Toshihiko and Matsuhashi, Masao and Yoshida, Kazumichi and Ikeda, Akio and Takahashi, Ryosuke and Ralph, Matthew A. Lambon and Miyamoto, Susumu}, doi = {10.1093/cercor/bhaa065}, journal-iso = {CEREB CORTEX}, journal = {CEREBRAL CORTEX}, volume = {30}, unique-id = {31685308}, issn = {1047-3211}, abstract = {In the dual-stream model of language processing, the exact connectivity of the ventral stream to the anterior temporal lobe remains elusive. To investigate the connectivity between the inferior frontal gyrus (IFG) and the lateral part of the temporal and parietal lobes, we integrated spatiotemporal profiles of cortico-cortical evoked potentials (CCEPs) recorded intraoperatively in 14 patients who had undergone surgical resection for a brain tumor or epileptic focus. Four-dimensional visualization of the combined CCEP data showed that the pars opercularis (Broca's area) is connected to the posterior temporal cortices and the supramarginal gyrus, whereas the pars orbitalis is connected to the anterior lateral temporal cortices and angular gyrus. Quantitative topographical analysis of CCEP connectivity confirmed an anterior-posterior gradient of connectivity from IFG stimulus sites to the temporal response sites. Reciprocality analysis indicated that the anterior part of the IFG is bidirectionally connected to the temporal or parietal area. This study shows that each IFG subdivision has different connectivity to the temporal lobe with an anterior-posterior gradient and supports the classical connectivity concept of Dejerine; that is, the frontal lobe is connected to the temporal lobe through the arcuate fasciculus and also a double fan-shaped structure anchored at the limen insulae.}, keywords = {Cortico-cortical evoked potential; 4D visualization; dual-stream language model; fronto-temporal radiation}, year = {2020}, eissn = {1460-2199}, pages = {4633-4650} } @article{MTMT:31295717, title = {In vivo-assessment of the human temporal network: Evidence for asymmetrical effective connectivity}, url = {https://m2.mtmt.hu/api/publication/31295717}, author = {Novitskaya, Y. and Dümpelmann, M. and Vlachos, A. and Reinacher, P.C. and Schulze-Bonhage, A.}, doi = {10.1016/j.neuroimage.2020.116769}, journal-iso = {NEUROIMAGE}, journal = {NEUROIMAGE}, volume = {214}, unique-id = {31295717}, issn = {1053-8119}, keywords = {Adult; Adolescent; Female; Middle Aged; Male; hippocampus; EPILEPSY; ARTICLE; human; priority journal; cohort analysis; nuclear magnetic resonance imaging; evoked cortical response; Parahippocampal Gyrus; clinical article; Temporal Lobe; Young Adult; in vivo study; clinical assessment; brain asymmetry; ASYMMETRY; nerve cell network; functional connectivity; spatiotemporal analysis; Effective connectivity; CCEP; neuromuscular electrical stimulation; Human temporal lobe; Reciprocal connectivity; amygdala}, year = {2020}, eissn = {1095-9572} } @article{MTMT:31406146, title = {Cingulate cortex function and multi-modal connectivity mapped using intracranial stimulation}, url = {https://m2.mtmt.hu/api/publication/31406146}, author = {Oane, I. and Barborica, A. and Chetan, F. and Donos, C. and Maliia, M.D. and Arbune, A.A. and Daneasa, A. and Pistol, C. and Nica, A.E. and Bajenaru, O.A. and Mindruta, I.}, doi = {10.1016/j.neuroimage.2020.117059}, journal-iso = {NEUROIMAGE}, journal = {NEUROIMAGE}, volume = {220}, unique-id = {31406146}, issn = {1053-8119}, year = {2020}, eissn = {1095-9572} } @article{MTMT:31406150, title = {Quantifying volume conducted potential using stimulation artefact in cortico-cortical evoked potentials}, url = {https://m2.mtmt.hu/api/publication/31406150}, author = {Prime, D. and Woolfe, M. and O'Keefe, S. and Rowlands, D. and Dionisio, S.}, doi = {10.1016/j.jneumeth.2020.108639}, journal-iso = {J NEUROSCI METH}, journal = {JOURNAL OF NEUROSCIENCE METHODS}, volume = {337}, unique-id = {31406150}, issn = {0165-0270}, year = {2020}, eissn = {1872-678X} } @article{MTMT:31295716, title = {Dynamic tractography: Integrating cortico-cortical evoked potentials and diffusion imaging}, url = {https://m2.mtmt.hu/api/publication/31295716}, author = {Silverstein, B.H. and Asano, E. and Sugiura, A. and Sonoda, M. and Lee, M.-H. and Jeong, J.-W.}, doi = {10.1016/j.neuroimage.2020.116763}, journal-iso = {NEUROIMAGE}, journal = {NEUROIMAGE}, volume = {215}, unique-id = {31295716}, issn = {1053-8119}, keywords = {electrocorticography; Effective connectivity; epilepsy surgery; Functional brain mapping; diffusion-weighted imaging tractography; Cortico-cortical evoked potentials (CCEP)}, year = {2020}, eissn = {1095-9572} } @article{MTMT:31406151, title = {Four-dimensional map of direct effective connectivity from posterior visual areas}, url = {https://m2.mtmt.hu/api/publication/31406151}, author = {Sugiura, A. and Silverstein, B.H. and Jeong, J.-W. and Nakai, Y. and Sonoda, M. and Motoi, H. and Asano, E.}, doi = {10.1016/j.neuroimage.2020.116548}, journal-iso = {NEUROIMAGE}, journal = {NEUROIMAGE}, volume = {210}, unique-id = {31406151}, issn = {1053-8119}, year = {2020}, eissn = {1095-9572} } @article{MTMT:31138680, title = {Does single stimulus elucidate the complex mystery of sleep?}, url = {https://m2.mtmt.hu/api/publication/31138680}, author = {Usami, K.}, doi = {10.1016/j.clinph.2019.11.010}, journal-iso = {CLIN NEUROPHYSIOL}, journal = {CLINICAL NEUROPHYSIOLOGY}, volume = {131}, unique-id = {31138680}, issn = {1388-2457}, year = {2020}, eissn = {1872-8952}, pages = {463-464} } @article{MTMT:30388857, title = {A quantitative method for evaluating cortical responses to electrical stimulation}, url = {https://m2.mtmt.hu/api/publication/30388857}, author = {Crowther, Lawrence J. and Brunner, Peter and Kapeller, Christoph and Guger, Christoph and Kamada, Kyousuke and Bunch, Marjorie E. and Frawley, Bridget K. and Lynch, Timothy M. and Ritaccio, Anthony L. and Schalk, Gerwin}, doi = {10.1016/j.jneumeth.2018.09.034}, journal-iso = {J NEUROSCI METH}, journal = {JOURNAL OF NEUROSCIENCE METHODS}, volume = {311}, unique-id = {30388857}, issn = {0165-0270}, abstract = {Background: Electrical stimulation of the cortex using subdurally implanted electrodes can causally reveal structural connectivity by eliciting cortico-cortical evoked potentials (CCEPs). While many studies have demonstrated the potential value of CCEPs, the methods to evaluate them were often relatively subjective, did not consider potential artifacts, and did not lend themselves to systematic scientific investigations.}, keywords = {electrocorticography; Connectivity; electrical stimulation; Cortico-cortical evoked potentials}, year = {2019}, eissn = {1872-678X}, pages = {67-75}, orcid-numbers = {Brunner, Peter/0000-0002-2588-2754} } @article{MTMT:31021978, title = {A Comparison of Evoked and Non-evoked Functional Networks}, url = {https://m2.mtmt.hu/api/publication/31021978}, author = {Hebbink, Jurgen and van Blooijs, Dorien and Huiskamp, Geertjan and Leijten, Frans S. S. and van Gils, Stephan A. and Meijer, Hil G. E.}, doi = {10.1007/s10548-018-0692-1}, journal-iso = {BRAIN TOPOGR}, journal = {BRAIN TOPOGRAPHY}, volume = {32}, unique-id = {31021978}, issn = {0896-0267}, abstract = {The growing interest in brain networks to study the brain's function in cognition and diseases has produced an increase in methods to extract these networks. Typically, each method yields a different network. Therefore, one may ask what the resulting networks represent. To address this issue we consider electrocorticography (ECoG) data where we compare three methods. We derive networks from on-going ECoG data using two traditional methods: cross-correlation (CC) and Granger causality (GC). Next, connectivity is probed actively using single pulse electrical stimulation (SPES). We compare the overlap in connectivity between these three methods as well as their ability to reveal well-known anatomical connections in the language circuit. We find that strong connections in the CC network form more or less a subset of the SPES network. GC and SPES are related more weakly, although GC connections coincide more frequently with SPES connections compared to non-existing SPES connections. Connectivity between the two major hubs in the language circuit, Broca's and Wernicke's area, is only found in SPES networks. Our results are of interest for the use of patient-specific networks obtained from ECoG. In epilepsy research, such networks form the basis for methods that predict the effect of epilepsy surgery. For this application SPES networks are interesting as they disclose more physiological connections compared to CC and GC networks.}, keywords = {electrocorticography; functional connectivity; BRAIN NETWORKS; Cortico-cortical evoked potentials; single pulse electrical stimulation}, year = {2019}, eissn = {1573-6792}, pages = {405-417}, orcid-numbers = {van Blooijs, Dorien/0000-0002-7998-414X} } @article{MTMT:31020318, title = {Intracortical Dynamics Underlying Repetitive Stimulation Predicts Changes in Network Connectivity}, url = {https://m2.mtmt.hu/api/publication/31020318}, author = {Huang, Yuhao and Hajnal, Boglárka Zsófia and Entz, László and Fabó, Dániel and Herrero, Jose L. and Mehta, Ashesh D. and Keller, Corey J.}, doi = {10.1523/JNEUROSCI.0535-19.2019}, journal-iso = {J NEUROSCI}, journal = {JOURNAL OF NEUROSCIENCE}, volume = {39}, unique-id = {31020318}, issn = {0270-6474}, abstract = {Targeted stimulation can be used to modulate the activity of brain networks. Previously we demonstrated that direct electrical stimulation produces predictable poststimulation changes in brain excitability. However, understanding the neural dynamics during stimulation and its relationship to poststimulation effects is limited but critical for treatment optimization. Here, we applied 10 Hz direct electrical stimulation across several cortical regions in 14 human subjects (6 males) implanted with intracranial electrodes for seizure monitoring. The stimulation train was characterized by a consistent increase in high gamma (70 -170 Hz) power. Immediately post-train, low-frequency (1-8 Hz) power increased, resulting in an evoked response that was highly correlated with the neural response during stimulation. Using two measures of network connectivity, corticocortical evoked potentials (indexing effective connectivity), and theta coherence (indexing functional connectivity), we found a stronger response to stimulation in regions that were highly connected to the stimulation site. In these regions, repeated cycles of stimulation trains and rest progressively altered the stimulation response. Finally, after just 2 min (similar to 10%) of repetitive stimulation, we were able to predict poststimulation connectivity changes with high disc rim inability. Together, this work reveals a relationship between stimulation dynamics and poststimulation connectivity changes in humans. Thus, measuring neural activity during stimulation can inform future plasticity-inducing protocols.}, keywords = {electrocorticography; PLASTICITY; electrical stimulation; neuromodulation; Cortico-cortical evoked potentials; Repetitive stimulation}, year = {2019}, eissn = {1529-2401}, pages = {6122-6135}, orcid-numbers = {Fabó, Dániel/0000-0001-5141-5351} } @article{MTMT:31025419, title = {A Human Induced Pluripotent Stem Cell-Derived Tissue Model of a Cerebral Tract Connecting Two Cortical Regions}, url = {https://m2.mtmt.hu/api/publication/31025419}, author = {Kirihara, Takaaki and Luo, Zhongyue and Chow, Siu Yu A. and Misawa, Ryuji and Kawada, Jiro and Shibata, Shinsuke and Khoyratee, Farad and Vollette, Carole Anne and Volz, Valentine and Levi, Timothee and Fujii, Teruo and Ikeuchi, Yoshiho}, doi = {10.1016/j.isci.2019.03.012}, journal-iso = {ISCIENCE}, journal = {ISCIENCE}, volume = {14}, unique-id = {31025419}, abstract = {Cerebral tracts connect separated regions within a brain and serve as fundamental structures that support integrative brain functions. However, understanding the mechanisms of cerebral tract development, macro-circuit formation, and related disorders has been hampered by the lack of an in vitro model. Here, we developed a human stem cell-derived model of cerebral tracts, which is composed of two spheroids of cortical neurons and a robust fascicle of axons linking these spheroids reciprocally. In a microdevice, two spheroids of cerebral neurons extended axons into a microchannel between the spheroids and spontaneously formed an axon fascicle, mimicking a cerebral tract. We found that the formation of axon fascicle was significantly promoted when two spheroids extended axons toward each other compared with axons extended from only one spheroid. The two spheroids were able to communicate electrically through the axon fascicle. This model tissue could facilitate studies of cerebral tract development and diseases.}, year = {2019}, eissn = {2589-0042}, pages = {301-+} } @article{MTMT:31021974, title = {Validation of corpus callosotomy after laser interstitial thermal therapy: a multimodal approach}, url = {https://m2.mtmt.hu/api/publication/31021974}, author = {Lehner, Kurt R. and Yeagle, Erin M. and Argyelan, Miklos and Klimaj, Zoltan and Du, Victor and Megevand, Pierre and Hwang, Sean T. and Mehta, Ashesh D.}, doi = {10.3171/2018.4.JNS172588}, journal-iso = {J NEUROSURG}, journal = {JOURNAL OF NEUROSURGERY}, volume = {131}, unique-id = {31021974}, issn = {0022-3085}, abstract = {OBJECTIVE Disconnection of the cerebral hemispheres by corpus callosotomy (CC) is an established means to palliate refractory generalized epilepsy. Laser interstitial thermal therapy (LITT) is gaining acceptance as a minimally invasive approach to treating epilepsy, but this method has not been evaluated in clinical series using established methodologies to assess connectivity. The goal in this study was to demonstrate the safety and feasibility of MRI-guided LITT for CC and to assess disconnection by using electrophysiology- and imaging-based methods.METHODS Retrospective chart and imaging review was performed in 5 patients undergoing LITT callosotomy at a single center. Diffusion tensor imaging and resting functional MRI were performed in all patients to assess anatomical and functional connectivity. In 3 patients undergoing simultaneous intracranial electroencephalography monitoring, corticocortical evoked potentials and resting electrocorticography were used to assess electrophysiological correlates.RESULTS All patients had generalized or multifocal seizure onsets. Three patients with preoperative evidence for possible lateralization underwent stereoelectroencephalography depth electrode implantation during the perioperative period. LITT ablation of the anterior corpus callosum was completed in a single procedure in 4 patients. One complication involving misplaced devices required a second procedure. Adequacy of the anterior callosotomy was confirmed using contrast-enhanced MRI and diffusion tensor imaging. Resting functional MRI, corticocortical evoked potentials, and resting electrocorticography demonstrated functional disconnection of the hemispheres. Postcallosotomy monitoring revealed lateralization of the seizures in all 3 patients with preoperatively suspected occult lateralization. Four of 5 patients experienced > 80% reduction in generalized seizure frequency. Two patients undergoing subsequent focal resection are free of clinical seizures at 2 years. One patient developed a 9-mm intraparenchymal hematoma at the site of entry and continued to have seizures after the procedure.CONCLUSIONS MRI-guided LITT provides an effective minimally invasive alternative method for CC in the treatment of seizures associated with drop attacks, bilaterally synchronous onset, and rapid secondary generalization. The disconnection is confirmed using anatomical and functional neuroimaging and electrophysiological measures.}, keywords = {surgical technique; Magnetic Resonance Imaging; LASERS; corpus callosum; Drug-resistant epilepsy}, year = {2019}, eissn = {1933-0693}, pages = {1095-1105} } @article{MTMT:31021981, title = {Cortical Responses to Input From Distant Areas are Modulated by Local Spontaneous Alpha/Beta Oscillations}, url = {https://m2.mtmt.hu/api/publication/31021981}, author = {Usami, Kiyohide and Milsap, Griffin W. and Korzeniewska, Anna and Collard, Maxwell J. and Wang, Yujing and Lesser, Ronald P. and Anderson, William S. and Crone, Nathan E.}, doi = {10.1093/cercor/bhx361}, journal-iso = {CEREB CORTEX}, journal = {CEREBRAL CORTEX}, volume = {29}, unique-id = {31021981}, issn = {1047-3211}, abstract = {Any given area in human cortex may receive input from multiple, functionally heterogeneous areas, potentially representing different processing threads. Alpha (8-13 Hz) and beta oscillations (13-20 Hz) have been hypothesized by other investigators to gate local cortical processing, but their influence on cortical responses to input from other cortical areas is unknown. To study this, we measured the effect of local oscillatory power and phase on cortical responses elicited by single-pulse electrical stimulation (SPES) at distant cortical sites, in awake human subjects implanted with intracranial electrodes for epilepsy surgery. In 4 out of 5 subjects, the amplitudes of corticocortical evoked potentials (CCEPs) elicited by distant SPES were reproducibly modulated by the power, but not the phase, of local oscillations in alpha and beta frequencies. Specifically, CCEP amplitudes were higher when average oscillatory power just before distant SPES (-110 to -10 ms) was high. This effect was observed in only a subset (0-33%) of sites with CCEPs and, like the CCEPs themselves, varied with stimulation at different distant sites. Our results suggest that although alpha and beta oscillations may gate local processing, they may also enhance the responsiveness of cortex to input from distant cortical sites.}, keywords = {BETA; ALPHA; CCEP; high gamma; single-pulse electrical stimulation}, year = {2019}, eissn = {1460-2199}, pages = {777-787} } @article{MTMT:31021975, title = {The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation}, url = {https://m2.mtmt.hu/api/publication/31021975}, author = {Usami, Kiyohide and Korzeniewska, Anna and Matsumoto, Riki and Kobayashi, Katsuya and Hitomi, Takefumi and Matsuhashi, Masao and Kunieda, Takeharu and Mikuni, Nobuhiro and Kikuchi, Takayuki and Yoshida, Kazumichi and Miyamoto, Susumu and Takahashi, Ryosuke and Ikeda, Akio and Crone, Nathan E.}, doi = {10.1093/sleep/zsz050}, journal-iso = {SLEEP}, journal = {SLEEP}, volume = {42}, unique-id = {31021975}, issn = {0161-8105}, abstract = {Wakefulness and sleep arise from global changes in brain physiology that may also govern the flow of neural activity between cortical regions responsible for perceptual processing versus planning and action. To test whether and how the sleep/wake cycle affects the overall propagation of neural activity in large-scale brain networks, we applied single-pulse electrical stimulation (SPES) in patients implanted with intracranial EEG electrodes for epilepsy surgery. SPES elicited cortico-cortical spectral responses at high-gamma frequencies (CCSRHG, 80-150 Hz), which indexes changes in neuronal population firing rates. Using event-related causality (ERC) analysis, we found that the overall patterns of neural propagation among sites with CCSRHG were different during wakefulness and different sleep stages. For example, stimulation of frontal lobe elicited greater propagation toward parietal lobe during slow-wave sleep than during wakefulness. During REM sleep, we observed a decrease in propagation within frontal lobe, and an increase in propagation within parietal lobe, elicited by frontal and parietal stimulation, respectively. These biases in the directionality of large-scale cortical network dynamics during REM sleep could potentially account for some of the unique experiential aspects of this sleep stage. Together these findings suggest that the regulation of conscious awareness and sleep is associated with differences in the balance of neural propagation across large-scale frontal-parietal networks.}, keywords = {Brain Waves; Effective connectivity; human electrocorticography; high-gamma activity; causal interactions}, year = {2019}, eissn = {1550-9109}, orcid-numbers = {Matsumoto, Riki/0000-0003-3985-9210} } @article{MTMT:31019262, title = {Spatial and Temporal Heterogeneities of Capillary Hemodynamics and Its Functional Coupling During Neural Activation}, url = {https://m2.mtmt.hu/api/publication/31019262}, author = {Wei, Wei and Li, Yuandong and Xie, Zhiying and Deegan, Anthony J. and Wang, Ruikang K.}, doi = {10.1109/TMI.2018.2883244}, journal-iso = {IEEE T MED IMAGING}, journal = {IEEE TRANSACTIONS ON MEDICAL IMAGING}, volume = {38}, unique-id = {31019262}, issn = {0278-0062}, abstract = {The cerebral vascular system provides a means to meet the constant metabolic needs of neuronal activities in the brain. Within the cerebral capillary bed, the interactions of spatial and temporal hemodynamics play a deterministic role in oxygen diffusion, however, the progression of which remains unclear. Taking the advantages of high-spatiotemporal resolution of optical coherence tomography capillary velocimetry designed with the eigen-decomposition statistical analysis, we investigated intrinsic red blood cell (RBC) velocities and their spatiotemporal adjustment within the capillaries permeating mouse cerebral cortex during electrical stimulation of contralateral hind paw. We found that the mean capillary transit velocity (mCTV) is increased and its temporal fluctuation bandwidth (TFB) is broadened within hind-paw somatosensory cortex. In addition, the degree to which the mCTV is increased negatively correlates with resting state mCTV, and the degree to which the TFB is increased negatively correlates with both the resting state mCTV and the TFB. In order to confirm the changes are due to hemodynamic regulation, we performed angiographic analyses and found that the vessel density remains almost constant, suggesting the observed functional activation does not involve recruitment of reserved capillaries. To further differentiate the contributions of the mCTV and the TFB to the spatiotemporally coupled hemodynamics, changes in the mCTV and TBF of the capillary flow were modeled and investigated through a Monte Carlo simulation. The results suggest that neural activation evokes the spatial transit time homogenization within the capillary bed, which is regulated via both the heterogeneous acceleration of RBC flow and the heterogeneous increase of temporal RBC fluctuation, ensuring sufficient oxygenation during functional hyperemia.}, keywords = {Spatial heterogeneity; Neural activation; optical coherence tomography angiography; Capillary hemodynamics; hind-pawelectrical stimulation; mean capillary transit velocity; temporal RBC fluctuation}, year = {2019}, eissn = {1558-0062}, pages = {1295-1303}, orcid-numbers = {Wei, Wei/0000-0002-1731-9339} } @article{MTMT:30512872, title = {Monitoring Corticocortical Evoked Potentials During Intracranial Vascular Surgery}, url = {https://m2.mtmt.hu/api/publication/30512872}, author = {Yoshimoto, Tetsuyuki and Maruichi, Katsuhiko and Itoh, Yasuhiro and Takamiya, Soichiro and Kaneko, Tetsuya}, doi = {10.1016/j.wneu.2018.10.179}, journal-iso = {WORLD NEUROSURG}, journal = {WORLD NEUROSURGERY}, volume = {122}, unique-id = {30512872}, issn = {1878-8750}, abstract = {BACKGROUND: Monitoring of corticocortical evoked potentials (CCEPs) during brain tumor surgery of patients under anesthesia was recently reported to be effective in assisting in preservation of speech function. The aim of this study was to investigate whether CCEPs can be reproducibly measured between the frontal and temporal lobes during standard intracranial vascular surgery under general anesthesia; whether dynamic changes in CCEPs caused by reduced focal cerebral blood flow can be measured; and whether CCEPs can be used to monitor speech function, particularly associated with the left side of the brain.}, keywords = {ISCHEMIA; BYPASS; clipping; CCEP; Speech function}, year = {2019}, eissn = {1878-8769}, pages = {E947-E954} } @article{MTMT:31025416, title = {Localization of Epileptogenic Zone Based on Cortico-Cortical Evoked Potential (CCEP): A Feature Extraction and Graph Theory Approach}, url = {https://m2.mtmt.hu/api/publication/31025416}, author = {Zhao, Cui and Liang, Ying and Li, Chunlin and Gao, Runshi and Wei, Jing and Zuo, Rui and Zhong, Yihua and Ren, Zhaohui and Geng, Xinling and Zhang, Guojun and Zhang, Xu}, doi = {10.3389/fninf.2019.00031}, journal-iso = {FRONT NEUROINFORM}, journal = {FRONTIERS IN NEUROINFORMATICS}, volume = {13}, unique-id = {31025416}, abstract = {Objective: Epilepsy is a chronic brain disease, which is prone to relapse and affects individuals of all ages worldwide, particularly the very young and elderly. Up to one-third of these patients are medically intractable and require resection surgery. However, the outcomes of epilepsy surgery rely upon the clear identification of epileptogenic zone (EZ). The combination of cortico-cortical evoked potential (CCEP) and electrocorticography (ECoG) provides an opportunity to observe the connectivity of human brain network and more comprehensive information that may help the clinicians localize the epileptogenic focus more precisely. However, there is no standard analysis method in the clinical application of CCEPs, especially for the quantitative analysis of abnormal connectivity of epileptic networks. The aim of this paper was to present an approach on the batch processing of CCEPs and provide information relating to the localization of EZ for clinical study.Methods: Eight medically intractable epilepsy patients were included in this study. Each patient was implanted with subdural grid electrodes and electrical stimulations were applied directly to their cortex to induce CCEPs. After signal preprocessing, we constructed three effective brain networks at different spatial scales for each patient, regarding the amplitudes of CCEPs as the connection weights. Graph theory was then applied to analyze the brain network topology of epileptic patients, and the topological metrics of EZ and non-EZ (NEZ) were compared.Results: The effective connectivity network reconstructed from CCEPs was asymmetric, both the number and the amplitudes of effective CCEPs decreased with increasing distance between stimulating and recording sites. Besides, the distribution of CCEP responses was associated with the locations of EZ which tended to have higher degree centrality (DC) and nodal shortest path length (NLP) than NEZ.Conclusion: Our results indicated that the brain networks of epileptics were asymmetric and mainly composed of short-distance connections. The DC and NLP were highly consistent to the distribution of the EZ, and these topological parameters have great potential to be readily applied to the clinical localization of the EZ.}, keywords = {EPILEPSY; ECoG; Graph theory; CCEP; effective connection}, year = {2019}, eissn = {1662-5196} } @article{MTMT:27302984, title = {Effective Connectivity Measured Using Optogenetically Evoked Hemodynamic Signals Exhibits Topography Distinct from Resting State Functional Connectivity in the Mouse}, url = {https://m2.mtmt.hu/api/publication/27302984}, author = {Bauer, Adam Q and Kraft, Andrew W and Baxter, Grant A and Wright, Patrick W and Reisman, Matthew D and Bice, Annie R and Park, Jasmine J and Bruchas, Michael R and Snyder, Abraham Z and Lee, Jin-Moo and Culver, Joseph P}, doi = {10.1093/cercor/bhx298}, journal-iso = {CEREB CORTEX}, journal = {CEREBRAL CORTEX}, volume = {28}, unique-id = {27302984}, issn = {1047-3211}, year = {2018}, eissn = {1460-2199}, pages = {370-386} } @article{MTMT:27302990, title = {Intracranial Electrophysiology of the Human Default Network}, url = {https://m2.mtmt.hu/api/publication/27302990}, author = {Fox, Kieran C R and Foster, Brett L and Kucyi, Aaron and Daitch, Amy L and Parvizi, Josef}, doi = {10.1016/j.tics.2018.02.002}, journal-iso = {TRENDS COGN SCI}, journal = {TRENDS IN COGNITIVE SCIENCES}, volume = {22}, unique-id = {27302990}, issn = {1364-6613}, year = {2018}, eissn = {1879-307X}, pages = {307-324} } @article{MTMT:27555163, title = {Induction and Quantification of Excitability Changes in Human Cortical Networks}, url = {https://m2.mtmt.hu/api/publication/27555163}, author = {Keller, Corey J and Huang, Yuhao and Herrero, Jose L and Fini, Maria E and Du, Victor and Lado, Fred A and Honey, Christopher J and Mehta, Ashesh D}, doi = {10.1523/JNEUROSCI.1088-17.2018}, journal-iso = {J NEUROSCI}, journal = {JOURNAL OF NEUROSCIENCE}, volume = {38}, unique-id = {27555163}, issn = {0270-6474}, year = {2018}, eissn = {1529-2401}, pages = {S384-S398} } @article{MTMT:27416490, title = {Sparse estimation of resting-state effective connectivity from fMRI cross-spectra}, url = {https://m2.mtmt.hu/api/publication/27416490}, author = {Lennartz, C and Schiefer, J and Rotter, S and Hennig, J and LeVan, P}, doi = {10.3389/fnins.2018.00287}, journal-iso = {FRONT NEUROSCI-SWITZ}, journal = {FRONTIERS IN NEUROSCIENCE}, volume = {12}, unique-id = {27416490}, issn = {1662-4548}, year = {2018}, eissn = {1662-453X} } @article{MTMT:27051926, title = {Structural and effective connectivity in focal epilepsy}, url = {https://m2.mtmt.hu/api/publication/27051926}, author = {Parker, CS and Clayden, JD and Cardoso, MJ and Rodionov, R and Duncan, JS and Scott, C and Diehl, B and Ourselin, S}, doi = {10.1016/j.nicl.2017.12.020}, journal-iso = {NEUROIMAGE-CLIN}, journal = {NEUROIMAGE-CLINICAL}, volume = {17}, unique-id = {27051926}, issn = {2213-1582}, year = {2018}, eissn = {2213-1582}, pages = {943-952} } @article{MTMT:30387610, title = {Probabilistic functional tractography of the human cortex revisited}, url = {https://m2.mtmt.hu/api/publication/30387610}, author = {Trebaul, Lena and Deman, Pierre and Tuyisenge, Viateur and Jedynak, Maciej and Hugues, Etienne and Rudrauf, David and Bhattacharjee, Manik and Tadel, Francois and Chanteloup-Foret, Blandine and Saubat, Carole and Mejia, Gina Catalina Reyes and Adam, Claude and Nica, Anca and Pail, Martin and Dubeau, Francois and Rheims, Sylvain and Trebuchon, Agnes and Wang, Haixiang and Liu, Sinclair and Blauwblomme, Thomas and Garces, Mercedes and De Palma, Luca and Valentin, Antonio and Metsahonkala, Eeva-Liisa and Petrescu, Ana Maria and Landre, Elizabeth and Szurhaj, William and Hirsch, Edouard and Valton, Luc and Rocamora, Rodrigo and Schulze-Bonhage, Andreas and Mindruta, Ioana and Francione, Stefano and Maillard, Louis and Taussig, Delphine and Kahane, Philippe and David, Olivier}, doi = {10.1016/j.neuroimage.2018.07.039}, journal-iso = {NEUROIMAGE}, journal = {NEUROIMAGE}, volume = {181}, unique-id = {30387610}, issn = {1053-8119}, abstract = {In patients with pharmaco-resistant focal epilepsies investigated with intracranial electroencephalography (iEEG), direct electrical stimulations of a cortical region induce cortico-cortical evoked potentials (CCEP) in distant cerebral cortex, which properties can be used to infer large scale brain connectivity. In 2013, we proposed a new probabilistic functional tractography methodology to study human brain connectivity. We have now been revisiting this method in the F-TRACT project (f-tract.eu) by developing a large multicenter CCEP database of several thousand stimulation runs performed in several hundred patients, and associated processing tools to create a probabilistic atlas of human cortico-cortical connections. Here, we wish to present a snapshot of the methods and data of F-TRACT using a pool of 213 epilepsy patients, all studied by stereo-encephalography with intracerebral depth electrodes. The CCEPs were processed using an automated pipeline with the following consecutive steps: detection of each stimulation run from stimulation artifacts in raw intracranial EEG (iEEG) files, bad channels detection with a machine learning approach, model-based stimulation artifact correction, robust averaging over stimulation pulses. Effective connectivity between the stimulated and recording areas is then inferred from the properties of the first CCEP component, i.e. onset and peak latency, amplitude, duration and integral of the significant part. Finally, group statistics of CCEP features are implemented for each brain parcel explored by iEEG electrodes. The localization (coordinates, white/gray matter relative positioning) of electrode contacts were obtained from imaging data (anatomical MRI or CT scans before and after electrodes implantation). The iEEG contacts were repositioned in different brain parcellations from the segmentation of patients' anatomical MRI or from templates in the MNI coordinate system. The F-TRACT database using the first pool of 213 patients provided connectivity probability values for 95% of possible intrahemispheric and 56% of interhemispheric connections and CCEP features for 78% of intrahemisheric and 14% of interhemispheric connections. In this report, we show some examples of anatomo-functional connectivity matrices, and associated directional maps. We also indicate how CCEP features, especially latencies, are related to spatial distances, and allow estimating the velocity distribution of neuronal signals at a large scale. Finally, we describe the impact on the estimated connectivity of the stimulation charge and of the contact localization according to the white or gray matter. The most relevant maps for the scientific community are available for download on f-tract. eu (David et al., 2017) and will be regularly updated during the following months with the addition of more data in the F-TRACT database. This will provide an unprecedented knowledge on the dynamical properties of large fiber tracts in human.}, keywords = {EPILEPSY; Brain atlas; Intracranial electroencephalogram; Cortico-cortical evoked potentials; Connectivity mapping}, year = {2018}, eissn = {1095-9572}, pages = {414-429}, orcid-numbers = {David, Olivier/0000-0003-0776-0216} } @article{MTMT:30387613, title = {Test-retest reliability of a stimulation-locked evoked response to deep brain stimulation in subcallosal cingulate for treatment resistant depression}, url = {https://m2.mtmt.hu/api/publication/30387613}, author = {Waters, Allison C. and Veerakumar, Ashan and Choi, Ki Sueng and Howell, Bryan and Tiruvadi, Vineet and Bijanki, Kelly R. and Crowell, Andrea and Riva-Posse, Patricio and Mayberg, Helen S.}, doi = {10.1002/hbm.24327}, journal-iso = {HUM BRAIN MAPP}, journal = {HUMAN BRAIN MAPPING}, volume = {39}, unique-id = {30387613}, issn = {1065-9471}, abstract = {Deep brain stimulation (DBS) to the subcallosal cingulate cortex (SCC) is an emerging therapy for treatment resistant depression. Precision targeting of specific white matter fibers is now central to the model of SCC DBS treatment efficacy. A method to confirm SCC DBS target engagement is needed to reduce procedural variance across treatment providers and to optimize DBS parameters for individual patients. We examined the reliability of a novel cortical evoked response that is time-locked to a 2 Hz DBS pulse and shows the propagation of signal from the DBS target. The evoked response was detected in four individuals as a stereotyped series of components within 150 ms of a 6 V DBS pulse, each showing coherent topography on the head surface. Test-retest reliability across four repeated measures over 14 months met or exceeded standards for valid test construction in three of four patients. Several observations in this pilot sample demonstrate the prospective utility of this method to confirm surgical target engagement and instruct parameter selection. The topography of an orbital frontal component on the head surface showed specificity for patterns of forceps minor activation, which may provide a means to confirm DBS location with respect to key white matter structures. A divergent cortical response to unilateral stimulation of left (vs. right) hemisphere underscores the need for feedback acuity on the level of a single electrode, despite bilateral presentation of therapeutic stimulation. Results demonstrate viability of this method to explore patient-specific cortical responsivity to DBS for brain-circuit pathologies.}, keywords = {Deep brain stimulation; treatment resistant depression; Cortico-cortical evoked potential; forceps minor; stimulation evoked potential; subcallosal cingulate cortex; white matter tractography}, year = {2018}, eissn = {1097-0193}, pages = {4844-4856} } @mastersthesis{MTMT:3241331, title = {In vivo validation and software control of active intracortical microelectrodes}, url = {https://m2.mtmt.hu/api/publication/3241331}, author = {Dombovári, Balázs Gábor}, doi = {10.15774/PPKE.ITK.2017.001}, publisher = {PPKE}, unique-id = {3241331}, year = {2017} } @{MTMT:31406154, title = {Connectomics in Patients with Temporal Lobe Epilepsy}, url = {https://m2.mtmt.hu/api/publication/31406154}, author = {Donos, Cristian and Barborica, Andrei and Mindruta, Ioana and Maliia, Mihai and Popa, Irina and Ciurea, Jean}, booktitle = {THE PHYSICS OF THE MIND AND BRAIN DISORDERS}, doi = {10.1007/978-3-319-29674-6_20}, unique-id = {31406154}, year = {2017}, pages = {447-468} } @article{MTMT:27302995, title = {Closed-loop interaction with the cerebral cortex using a novel micro-ECoG-based implant: the impact of beta vs. gamma stimulation frequencies on corticocortical spectral responses}, url = {https://m2.mtmt.hu/api/publication/27302995}, author = {Gkogkidis, C Alexis and Wang, Xi and Schubert, Tobias and Gierthmuehlen, Mortimer and Kohler, Fabian and Schulze-Bonhage, Andreas and Burgard, Wolfram and Rickert, Joern and Haberstroh, Joerg and Schuettler, Martin and Stieglitz, Thomas and Ball, Tonio}, doi = {10.1080/2326263X.2017.1381829}, journal-iso = {BRAIN-COMP INTERF}, journal = {BRAIN-COMPUTER INTERFACES}, volume = {4}, unique-id = {27302995}, issn = {2326-263X}, year = {2017}, eissn = {2326-2621}, pages = {214-224} } @article{MTMT:26741212, title = {Tuning Face Perception with Electrical Stimulation of the Fusiform Gyrus}, url = {https://m2.mtmt.hu/api/publication/26741212}, author = {Keller, Corey J and Davidesco, Ido and Megevand, Pierre and Lado, Fred A and Malach, Rafael and Mehta, Ashesh D}, doi = {10.1002/hbm.23543}, journal-iso = {HUM BRAIN MAPP}, journal = {HUMAN BRAIN MAPPING}, volume = {38}, unique-id = {26741212}, issn = {1065-9471}, year = {2017}, eissn = {1097-0193}, pages = {2830-2842} } @article{MTMT:27277945, title = {High frequency activity overriding cortico-cortical evoked potentials reflects altered excitability in the human epileptic focus}, url = {https://m2.mtmt.hu/api/publication/27277945}, author = {Kobayashi, Katsuya and Matsumoto, Riki and Matsuhashi, Masao and Usami, Kiyohide and Shimotake, Akihiro and Kunieda, Takeharu and Kikuchi, Takayuki and Yoshida, Kazumichi and Mikuni, Nobuhiro and Miyamoto, Susumu and Fukuyama, Hidenao and Takahashi, Ryosuke and Ikeda, Akio}, doi = {10.1016/j.clinph.2017.06.249}, journal-iso = {CLIN NEUROPHYSIOL}, journal = {CLINICAL NEUROPHYSIOLOGY}, volume = {128}, unique-id = {27277945}, issn = {1388-2457}, year = {2017}, eissn = {1872-8952}, pages = {1673-1681} } @article{MTMT:27072839, title = {Discrimination of a medial functional module within the temporal lobe using an effective connectivity model: A CCEP study}, url = {https://m2.mtmt.hu/api/publication/27072839}, author = {Krieg, Julien and Koessler, Laurent and Jonas, Jacques and Colnat-Coulbois, Sophie and Vignal, Jean-Pierre and Benar, Christian G and Maillard, Louis G}, doi = {10.1016/j.neuroimage.2017.07.061}, journal-iso = {NEUROIMAGE}, journal = {NEUROIMAGE}, volume = {161}, unique-id = {27072839}, issn = {1053-8119}, year = {2017}, eissn = {1095-9572}, pages = {219-231} } @article{MTMT:27277950, title = {Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy}, url = {https://m2.mtmt.hu/api/publication/27277950}, author = {Matsumoto, Riki and Kunieda, Takeharu and Nair, Dileep}, doi = {10.1016/j.seizure.2016.11.003}, journal-iso = {SEIZURE-EUR J EPILEP}, journal = {SEIZURE-EUROPEAN JOURNAL OF EPILEPSY}, volume = {44}, unique-id = {27277950}, issn = {1059-1311}, year = {2017}, eissn = {1532-2688}, pages = {27-36}, orcid-numbers = {Matsumoto, Riki/0000-0003-3985-9210} } @article{MTMT:27052168, title = {The Hippocampus and Amygdala Are Integrators of Neocortical Influence: A CorticoCortical Evoked Potential Study}, url = {https://m2.mtmt.hu/api/publication/27052168}, author = {Mégevand, P and Groppe, DM and Bickel, S and Mercier, MR and Goldfinger, MS and Keller, CJ and Entz, László and Mehta, AD}, doi = {10.1089/brain.2017.0527}, journal-iso = {BRAIN CONNECT}, journal = {BRAIN CONNECTIVITY}, volume = {7}, unique-id = {27052168}, issn = {2158-0014}, year = {2017}, eissn = {2158-0022}, pages = {648-660} } @article{MTMT:27277949, title = {Impact of volume-conducted potential in interpretation of cortico-cortical evoked potential: Detailed analysis of high-resolution electrocorticography using two mathematical approaches}, url = {https://m2.mtmt.hu/api/publication/27277949}, author = {Shimada, Seijiro and Kunii, Naoto and Kawai, Kensuke and Matsuo, Takeshi and Ishishita, Yohei and Ibayashi, Kenji and Saito, Nobuhito}, doi = {10.1016/j.clinph.2017.01.012}, journal-iso = {CLIN NEUROPHYSIOL}, journal = {CLINICAL NEUROPHYSIOLOGY}, volume = {128}, unique-id = {27277949}, issn = {1388-2457}, year = {2017}, eissn = {1872-8952}, pages = {549-557} } @article{MTMT:25830237, title = {Modulation of Cortical Oscillations by Low-Frequency Direct Cortical Stimulation Is State-Dependent}, url = {https://m2.mtmt.hu/api/publication/25830237}, author = {Alagapan, Sankaraleengam and Schmidt, Stephen L and Lefebvre, Jeremie and Hadar, Eldad and Shin, Hae Won and Froehlich, Flavio}, doi = {10.1371/journal.pbio.1002424}, journal-iso = {PLOS BIOL}, journal = {PLOS BIOLOGY}, volume = {14}, unique-id = {25830237}, issn = {1544-9173}, year = {2016}, eissn = {1545-7885} } @article{MTMT:26022699, title = {Single and paired-pulse electrical stimulation during invasive EEG recordings}, url = {https://m2.mtmt.hu/api/publication/26022699}, author = {Boulogne, S and Ryvlin, P and Rheims, S}, doi = {10.1016/j.neurol.2016.02.004}, journal-iso = {REV NEUROL-FRANCE}, journal = {REVUE NEUROLOGIQUE}, volume = {172}, unique-id = {26022699}, issn = {0035-3787}, year = {2016}, eissn = {2213-0004}, pages = {174-181} } @article{MTMT:26022712, title = {A connectomics approach combining structural and effective connectivity assessed by intracranial electrical stimulation}, url = {https://m2.mtmt.hu/api/publication/26022712}, author = {Donos, Cristian and Maliia, Mihai Dragos and Mindruta, Ioana and Popa, Irina and Ene, Mirela and Balanescu, Bogdan and Ciurea, Ana and Barborica, Andrei}, doi = {10.1016/j.neuroimage.2016.02.054}, journal-iso = {NEUROIMAGE}, journal = {NEUROIMAGE}, volume = {132}, unique-id = {26022712}, issn = {1053-8119}, year = {2016}, eissn = {1095-9572}, pages = {344-358}, orcid-numbers = {Donos, Cristian/0000-0003-2181-062X; Maliia, Mihai Dragos/0000-0002-5436-0314; Barborica, Andrei/0000-0001-6783-3769} } @article{MTMT:27278320, title = {Passive language mapping combining real-time oscillation analysis with cortico-cortical evoked potentials for awake craniotomy}, url = {https://m2.mtmt.hu/api/publication/27278320}, author = {Tamura, Yukie and Ogawa, Hiroshi and Kapeller, Christoph and Prueckl, Robert and Takeuchi, Fumiya and Anei, Ryogo and Ritaccio, Anthony and Guger, Christoph and Kamada, Kyousuke}, doi = {10.3171/2015.4.JNS15193}, journal-iso = {J NEUROSURG}, journal = {JOURNAL OF NEUROSURGERY}, volume = {125}, unique-id = {27278320}, issn = {0022-3085}, year = {2016}, eissn = {1933-0693}, pages = {1580-1588} } @mastersthesis{MTMT:26421929, title = {Development of multimodal diagnostic tools for epilepsy patients implanted with intracranial micro-and macroelectrodes}, url = {https://m2.mtmt.hu/api/publication/26421929}, author = {Tóth, Emília}, unique-id = {26421929}, year = {2016} } @article{MTMT:26022698, title = {Stimulation artifact correction method for estimation of early cortico-cortical evoked potentials}, url = {https://m2.mtmt.hu/api/publication/26022698}, author = {Trebaul, Lena and Rudrauf, David and Job, Anne-Sophie and Maliia, Mihai Dragos and Popa, Irina and Barborica, Andrei and Minotti, Lorella and Mindruta, Ioana and Kahane, Philippe and David, Olivier}, doi = {10.1016/j.jneumeth.2016.03.002}, journal-iso = {J NEUROSCI METH}, journal = {JOURNAL OF NEUROSCIENCE METHODS}, volume = {264}, unique-id = {26022698}, issn = {0165-0270}, year = {2016}, eissn = {1872-678X}, pages = {94-102}, orcid-numbers = {Maliia, Mihai Dragos/0000-0002-5436-0314} } @article{MTMT:27305090, title = {Probing functional brain networks with cortical electrical stimulation}, url = {https://m2.mtmt.hu/api/publication/27305090}, author = {Yamao, Y and Kunieda, T and Matsumoto, R}, doi = {10.7887/jcns.25.411}, journal-iso = {JAPANESE JOURNAL OF NEUROSURGERY}, journal = {JAPANESE JOURNAL OF NEUROSURGERY}, volume = {25}, unique-id = {27305090}, issn = {0917-950X}, year = {2016}, pages = {411-420} } @{MTMT:31295718, title = {Focal motor seizures}, url = {https://m2.mtmt.hu/api/publication/31295718}, author = {Alexopoulos, A.V. and Jones, S.E.}, booktitle = {Wyllie's Treatment of Epilepsy: Principles and Practice: Sixth Edition}, unique-id = {31295718}, year = {2015}, pages = {n-a} } @mastersthesis{MTMT:3143095, title = {Mapping the human brain with cortical electrical stimulation}, url = {https://m2.mtmt.hu/api/publication/3143095}, author = {Entz, László}, doi = {10.14753/SE.2015.1798}, publisher = {Semmelweis Egyetem}, unique-id = {3143095}, year = {2015} } @article{MTMT:27277952, title = {Different Mode of Afferents Determines the Frequency Range of High Frequency Activities in the Human Brain: Direct Electrocorticographic Comparison between Peripheral Nerve and Direct Cortical Stimulation}, url = {https://m2.mtmt.hu/api/publication/27277952}, author = {Kobayashi, Katsuya and Matsumoto, Riki and Matsuhashi, Masao and Usami, Kiyohide and Shimotake, Akihiro and Kunieda, Takeharu and Kikuchi, Takayuki and Mikuni, Nobuhiro and Miyamoto, Susumu and Fukuyama, Hidenao and Takahashi, Ryosuke and Ikeda, Akio}, doi = {10.1371/journal.pone.0130461}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {10}, unique-id = {27277952}, issn = {1932-6203}, year = {2015}, eissn = {1932-6203}, orcid-numbers = {Matsumoto, Riki/0000-0003-3985-9210} } @article{MTMT:27277953, title = {New Approach for Exploring Cerebral Functional Connectivity: Review of Cortico-cortical Evoked Potential}, url = {https://m2.mtmt.hu/api/publication/27277953}, author = {Kunieda, Takeharu and Yamao, Yukihiro and Kikuchi, Takayuki and Matsumoto, Riki}, doi = {10.2176/nmc.ra.2014-0388}, journal-iso = {NEUROL MED-CHIR}, journal = {NEUROLOGIA MEDICO-CHIRURGICA}, volume = {55}, unique-id = {27277953}, issn = {0470-8105}, year = {2015}, eissn = {1349-8029}, pages = {374-382}, orcid-numbers = {Yamao, Yukihiro/0000-0002-9615-2353; Matsumoto, Riki/0000-0003-3985-9210} } @mastersthesis{MTMT:26837082, title = {Wireless tools for neuromodulation}, url = {https://m2.mtmt.hu/api/publication/26837082}, author = {Lee, Steven T}, unique-id = {26837082}, year = {2015} } @article{MTMT:27277954, title = {Physiology of functional and effective networks in epilepsy}, url = {https://m2.mtmt.hu/api/publication/27277954}, author = {Yaffe, Robert B and Borger, Philip and Megevand, Pierre and Groppe, David M and Kramer, Mark A and Chu, Catherine J and Santaniello, Sabato and Meisel, Christian and Mehta, Ashesh D and Sarma, Sridevi V}, doi = {10.1016/j.clinph.2014.09.009}, journal-iso = {CLIN NEUROPHYSIOL}, journal = {CLINICAL NEUROPHYSIOLOGY}, volume = {126}, unique-id = {27277954}, issn = {1388-2457}, year = {2015}, eissn = {1872-8952}, pages = {227-236}, orcid-numbers = {Megevand, Pierre/0000-0002-0427-547X; Santaniello, Sabato/0000-0002-2133-9471} } @article{MTMT:2736859, title = {Mapping human brain networks with cortico-cortical evoked potentials}, url = {https://m2.mtmt.hu/api/publication/2736859}, author = {Keller, CJ and Honey, CJ and Mégevand, P and Entz, László and Ulbert, István and Mehta, AD}, doi = {10.1098/rstb.2013.0528}, journal-iso = {PHILOS T ROY SOC B}, journal = {PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B - BIOLOGICAL SCIENCES}, volume = {369}, unique-id = {2736859}, issn = {0962-8436}, abstract = {The cerebral cortex forms a sheet of neurons organized into a network of interconnected modules that is highly expanded in humans and presumably enables our most refined sensory and cognitive abilities. The links of this network form a fundamental aspect of its organization, and a great deal of research is focusing on understanding how information flows within and between different regions. However, an often-overlooked element of this connectivity regards a causal, hierarchical structure of regions, whereby certain nodes of the cortical network may exert greater influence over the others. While this is difficult to ascertain non-invasively, patients undergoing invasive electrode monitoring for epilepsy provide a unique window into this aspect of cortical organization. In this review, we highlight the potential for corticocortical evoked potential (CCEP) mapping to directly measure neuronal propagation across large-scale brain networks with spatio-temporal resolution that is superior to traditional neuroimaging methods.We first introduce effective connectivity and discuss the mechanisms underlying CCEP generation. Next, we highlight how CCEP mapping has begun to provide insight into the neural basis of non-invasive imaging signals. Finally, we present a novel approach to perturbing and measuring brain network function during cognitive processing. The direct measurement of CCEPs in response to electrical stimulation represents a potentially powerful clinical and basic science tool for probing the large-scale networks of the human cerebral cortex. © 2014 The Author(s) Published by the Royal Society. All rights reserved.}, keywords = {STIMULATION; electrocorticography; Graph theory; Effective connectivity; Cortico-cortical evoked potential}, year = {2014}, eissn = {1471-2970}, orcid-numbers = {Ulbert, István/0000-0001-9941-9159} }