TY - JOUR AU - Taymouri, Somayeh AU - Hasani, Faezeh AU - Mirian, Mina AU - Farhang, Armin AU - Varshosaz, Jaleh TI - Biocompatible nanocomposite scaffolds based on carrageenan incorporating hydroxyapatite and hesperidin loaded nanoparticles for bone tissue regeneration JF - POLYMERS FOR ADVANCED TECHNOLOGIES J2 - POLYM ADVAN TECHNOL VL - 35 PY - 2024 IS - 1 PG - 19 SN - 1042-7147 DO - 10.1002/pat.6284 UR - https://m2.mtmt.hu/api/publication/34607762 ID - 34607762 AB - In this study, injectable and osteoinductive carrageenan (CGN)-based composite hydrogel integrated with 1% wt/vol hydroxyapatite (HA) and hesperidin (HPN) loaded poly (3-hydroxybutyrate-co-3-hydroxyvalerate acid) nanoparticles (PHBV NPs) were developed as a scaffold for bone tissue engineering. Accordingly, HPN was encapsulated into PHBV NPs by the oil in water emulsion-solvent evaporation technique and optimized using the fractional factorial design. Then, the effects of the amount of drug, polymer, surfactant concentration, sonication time, and the water/organic phase volume ratio on the characteristics of NPs, including particle size (PS), polydispersity index (PdI), zeta potential (ZP), drug loading (DL) % and encapsulation efficiency (EE) % were investigated. The crystalline state of HPN and the interaction between the drug and the polymer were also investigated using the x-ray powder diffraction method and the Fourier transform infrared method, respectively. Further, CGN hydrogel was developed and loaded with optimized NPs and HA (HPN-PHBV NPs-CGN/HA hydrogel). The prepared hydrogel was then characterized for drug release, swelling and degradation behavior, mechanical properties, and injectability. In addition, the potential of the composite hydrogel as bone tissue scaffolds was assessed by the MTT assay, alkaline phosphatase (ALP) activity, and alizarin red S staining. The optimized formulation had the size of 353.5 nm, PdI of 0.43, EE% of 88.47%, DL% of 29.58% and the ZP of -17.4. HPN-PHBV NPs-CGN/HA hydrogel also showed sustained drug release, as compared to the HPN-CGN/HA hydrogel. Further, the hydrogel containing HA showed improved mechanical properties, as compared with the HA free one. In addition, HPN-PHBV NPs-CGN/HA hydrogel significantly enhanced MG63 cell proliferation, ALP activity and matrix mineralization, as compared with other groups. Overall, the use of this hydrogel with enhanced osteogenic capacity could be considered as an effective approach for bone tissue engineering. LA - English DB - MTMT ER - TY - JOUR AU - Guo, K. AU - Xiao, N. AU - Liu, Y. AU - Wang, Z. AU - Tóth, Judit AU - Gyenis, János AU - Thakur, V.K. AU - Oyane, A. AU - Shubhra, Q.T.H. TI - Engineering polymer nanoparticles using cell membrane coating technology and their application in cancer treatments: Opportunities and challenges JF - NANO MATERIALS SCIENCE J2 - NANO MATER SCI VL - 4 PY - 2022 IS - 2 SP - 295 EP - 321 PG - 27 SN - 2096-6482 DO - 10.1016/j.nanoms.2021.12.001 UR - https://m2.mtmt.hu/api/publication/32636317 ID - 32636317 N1 - Stomatology Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510140, China Department of Microbiology, The University of Chicago, Chicago, IL 60637, United States Department of Pathology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 21116, China State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, Magyar Tudósok Körútja 2, Budapest, 1117, Hungary University of Pannonia, Egyetem u. 10, H-8200, Veszprém, Hungary Nanomaterials Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, 305-8565, Japan School of Engineering, University of Petroleum & Energy Studies (UPES), Dehradun, 248007, India Export Date: 31 January 2022 Correspondence Address: Thakur, V.K.; School of Engineering, India; email: Vijay.Thakur@sruc.ac.uk Correspondence Address: Shubhra, Q.T.H.; Stomatology Hospital of Guangzhou Medical University, China; email: shubhro.du@gmail.com Funding text 1: We thank Ayesha Akhter (School of Science and Technology, Georgia Gwinnett College, USA) for assisting in language editing. AB - Nanotechnology has revolutionized cancer drug delivery, and recent research continues to focus on the development of “one-size- fits-all,” i.e., “all-in-one” delivery nanovehicles. Although nanomedicines can address significant shortcomings of conventional therapy, biological barriers remain a challenge in their delivery and accumulation at diseased sites. To achieve long circulation time, immune evasion, and targeted accumulation, conventional nanocarriers need modifications, e.g., PEGylation, peptide/aptamer attachment, etc. One such modification is a biomimetic coating using cell membrane (CM), which can offer long circulation or targeting, or both. This top-down CM coating process is facile and can provide some advantageous features over surface modification by synthetic polymers. Herein, an overview is provided on the engineering of CM camouflaged polymer nanoparticles. A short section on CM and the development of CM coating technology has been provided. Detailed description of the preparation and characterization of CM camouflaged polymer NPs and their applications in cancer treatment has been reported. A brief comparison between CM coating and PEGylation has been highlighted. Various targeting approaches to achieve tumor-specific delivery of CM coated NPs have been summarized here. Overall, this review will give the readers a nice picture of CM coated polymer NPs, along with their opportunities and challenges. © 2021 Chongqing University LA - English DB - MTMT ER - TY - JOUR AU - Guo, K. AU - Liu, Y. AU - Tang, L. AU - Shubhra, Q.T.H. TI - Homotypic biomimetic coating synergizes chemo-photothermal combination therapy to treat breast cancer overcoming drug resistance JF - CHEMICAL ENGINEERING JOURNAL J2 - CHEM ENG J VL - 428 PY - 2022 SN - 1385-8947 DO - 10.1016/j.cej.2021.131120 UR - https://m2.mtmt.hu/api/publication/32692358 ID - 32692358 N1 - Cited By :5 Export Date: 21 February 2022 CODEN: CMEJA Correspondence Address: Guo, K.; Fujian Key Laboratory of Innate Immune Biology, China; email: guokai956@gmail.com Funding details: Fujian Normal University Funding text 1: We are thankful to Dr. A.K.M. Moshiul Alam (BAEC, Bangladesh) and Xiao Nanyang (Fujian Normal University, China) for their suggestions and instrumental support. We also thank Mr. Gao Wang (Wuhan SenStar, China) for his support. AB - Breast cancer (BC) is a leading cause of death in women worldwide and multidrug resistance (MDR) severely limits its treatment since chemotherapy is the standard approach for treating BCs. In this work, high biocompatibility resulted from biomimetic coating, magnetic and homotypic targeting plus triggered release properties were integrated in one smart drug delivery system (DDS) to overcome drug resistance and to achieve combination cancer therapy. MCF-7 cancer cell membrane coating was applied to chitosan-PLGA based DDS entrapping photothermal iron oxide nanoparticles (PIO NPs), Doxorubicin (Dox) and Mcl-1-siRNA. Such coating facilitated homotypic targeting of MCF-7/ADR cells, whereas PIO NPs facilitated magnetic targeting by the external magnetic field, thereby resulting in high in vitro cellular uptake and in vivo accumulation at the tumor site. Upon NIR (near-infrared) laser irradiation and at acidic pH, the DDS exhibited triggered release. The cytotoxicity of Dox on MCF-7 and MCF-7/ADR cells significantly improved by the developed DDS due to increased intracellular Dox accumulation. Application of NIR laser and external magnetic field resulted in maximum therapeutic outcome utilizing chemo-photothermal combination and the DDS was able to inhibit almost 80% tumor growth in MCF-7/ADR tumor model. This new nanoplatform holds strong promise in BC therapy and can be exploited to treat other cancers. © 2021 Elsevier B.V. LA - English DB - MTMT ER - TY - JOUR AU - Guo, Kai AU - Liu, Yixuan AU - Ding, Min AU - Sun, Qi AU - Shubhra, Quazi T. H. TI - Enhanced drug release from a pH-responsive nanocarrier can augment colon cancer treatment by blocking PD-L1 checkpoint and consuming tumor glucose JF - MATERIALS AND DESIGN J2 - MATER DESIGN VL - 219 PY - 2022 PG - 10 SN - 0264-1275 DO - 10.1016/j.matdes.2022.110824 UR - https://m2.mtmt.hu/api/publication/32998172 ID - 32998172 AB - In this study, it was aimed to exploit no chemical drug to treat cancer by starvation-immunotherapy combination. We used PD-L1 siRNA to down-regulate checkpoint protein PD-L1 on cancer cell surfaces, and IFN-gamma was used as an immunomodulatory agent to activate the innate immune system. When PD-L1 siRNA, IFN-gamma, and glucose oxidase (GOx) were co-delivered to the tumor microenvironment (TME) by a pH-sensitive drug delivery system (DDS), starvation-immunotherapy combinedly resulted in significant tumor volume reduction in a mouse model. The DDS was prepared by using PLGA polymer whose surface was coated with chitosan. IFN-gamma, siRNA, and GOx entrapment efficiencies were 93.5 +/- 3.1%, 65.1 +/- 2.6%, and 66.2 +/- 3.3%, respectively. Moreover, the size of the DDS was well below 200 nm, allowing easy sterilization and tumor accumulation by the enhanced permeability and retention (EPR) effect. In vitro pH-dependent release study indicated that in acidic pH, the developed DDS can show accelerated drug release. In a mouse model and in acidic TME, the DDS resulted in the best therapeutic effect due to pH-dependent drug release compared to unmodified DDS and free drug. Our findings reflect that high efficiency in colon cancer treatment is achieved by combination therapy over the studied monotherapies. (C) 2022 The Authors. Published by Elsevier Ltd. LA - English DB - MTMT ER - TY - JOUR AU - Liu, Yixuan AU - Guo, Kai AU - Ding, Min AU - Zhang, Bingchen AU - Xiao, Nanyang AU - Tang, Zonghao AU - Wang, Zhengming AU - Zhang, Chengfei AU - Shubhra, Quazi T. H. TI - Engineered Magnetic Polymer Nanoparticles Can Ameliorate Breast Cancer Treatment Inducing Pyroptosis-Starvation along with Chemotherapy JF - ACS APPLIED MATERIALS & INTERFACES J2 - ACS APPL MATER INTER VL - 14 PY - 2022 IS - 37 SP - 42541 EP - 42557 PG - 17 SN - 1944-8244 DO - 10.1021/acsami.2c13011 UR - https://m2.mtmt.hu/api/publication/33218516 ID - 33218516 N1 - Department of Pathology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 21116, China Stomatology Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510140, China Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, Fuzhou, 350117, China Dongguan Hospital, Southern Medical University, Dongguan, 523795, China Department of Microbiology, The University of Chicago, Chicago, IL 60637, United States Drug Discovery Research Center, Southwest Medical University, Luzhou, 646000, China Cedars-Sinai Medical Center, Los Angeles, 90048, United States State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, China Translational Medicine Engineering Research Center of Guangdong Province, Foshan First People's Hospital, Foshan, 528000, China Cited By :2 Export Date: 22 March 2023 Correspondence Address: Zhang, C.; Department of Pathology, China; email: chengfeizhang@njmu.edu.cn Correspondence Address: Shubhra, Q.T.H.; Stomatology Hospital of Guangzhou Medical University, China; email: shubra@gzhmu.edu.cn AB - Nanotechnology has shown a revolution in cancer treatments, including breast cancers. However, there remain some challenges and translational hurdles. Surgery, radiotherapy, and chemotherapy are the primary treatment methods for breast cancer, although drug combinations showed promising results in preclinical studies. Herein we report the development of a smart drug delivery system (DDS) to efficiently treat breast cancer by pyroptosis-starvation-chemotherapeutic combination. Cancer-starvation agent glucose oxidase was chemically attached to synthesized iron oxide nanoparticles which were entrapped inside poly(lactic-co-glycolic acid) along with apoptosis-associated speck-like protein containing a caspase recruitment domain plasmid and paclitaxel (PTX). An emulsion solvent evaporation method was used to prepare the DDS. The surface of the DDS was modified with chitosan to which aptamer was attached to achieve site-specific targeting. Hence, the prepared DDS could be targeted to a tumor site by both external magnet and aptamer to obtain an enhanced accumulation of drugs at the tumor site. The final size of the aptamer-decorated DDS was less than 200 nm, and the encapsulation efficiency of PTX was 76.5 +/- 2.5%. Drug release from the developed DDS was much higher at pH 5.5 than at pH 7.4, ensuring the pH sensitivity of the DDS. Due to efficient dual targeting of the DDS, in vitro viability of 4T1 cells was reduced to 12.1 +/- 1.6%, whereas the nontargeted group and free PTX group could reduce the viability of cells to 29.2 +/- 2.4 and 46.2 +/- 1.6%, respectively. Our DDS showed a synergistic effect in vitro and no severe side effects in vivo. This DDS has strong potential to treat various cancers. LA - English DB - MTMT ER - TY - JOUR AU - Coll-Satue, C. AU - Jansman, M.M.T. AU - Thulstrup, P.W. AU - Hosta-Rigau, L. TI - Optimization of hemoglobin encapsulation within plga nanoparticles and their investigation as potential oxygen carriers JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 13 PY - 2021 IS - 11 SN - 1999-4923 DO - 10.3390/pharmaceutics13111958 UR - https://m2.mtmt.hu/api/publication/32692593 ID - 32692593 N1 - Center for Nanomedicine and Theranostics, Department of Health Technology, Technical University of Denmark, Nils Koppels Allé, Building 423, Kongens Lyngby, 2800, Denmark Department of Chemistry, University of Copenhagen, Universitetsparken 5, Copenhagen, 2100, Denmark Export Date: 21 February 2022 Correspondence Address: Hosta-Rigau, L.; Center for Nanomedicine and Theranostics, Building 423, Denmark; email: leri@dtu.dk Funding details: Natur og Univers, Det Frie Forskningsråd, FNU, DFF, 0136-00052B Funding text 1: Funding: This research was funded by the Danish Council for Independent research, grant number 0136-00052B. AB - Hemoglobin (Hb)-based oxygen carriers (HBOCs) display the excellent oxygen-carrying properties of red blood cells, while overcoming some of the limitations of donor blood. Various encapsulation platforms have been explored to prepare HBOCs which aim to avoid or minimize the adverse effects caused by the administration of free Hb. Herein, we entrapped Hb within a poly(lac-tide-co-glycolide) (PLGA) core, prepared by the double emulsion solvent evaporation method. We study the effect of the concentrations of Hb, PLGA, and emulsifier on the size, polydispersity (PDI), loading capacity (LC), and entrapment efficiency (EE) of the resulting Hb-loaded PLGA nanoparti-cles (HbNPs). Next, the ability of the HbNPs to reversibly bind and release oxygen was thoroughly evaluated. When needed, trehalose, a well-known protein stabilizer that has never been explored for the fabrication of HBOCs, was incorporated to preserve Hb’s functionality. The optimized formulation had a size of 344 nm, a PDI of 0.172, a LC of 26.9%, and an EE of 40.7%. The HbNPs were imaged by microscopy and were further characterized by FTIR and CD spectroscopy to assess their chemical composition and structure. Finally, the ability of the encapsulated Hb to bind and release oxygen over several rounds was demonstrated, showing the preservation of its functionality. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. LA - English DB - MTMT ER - TY - JOUR AU - Shubhra, Quazi T. H. AU - Guo, Kai AU - Liu, Yixuan AU - Razzak, Md AU - Manir, Md Serajum AU - Alam, A. K. M. Moshiul TI - Dual targeting smart drug delivery system for multimodal synergistic combination cancer therapy with re duce d cardiotoxicity JF - ACTA BIOMATERIALIA J2 - ACTA BIOMATER VL - 131 PY - 2021 SP - 493 EP - 507 PG - 15 SN - 1742-7061 DO - 10.1016/j.actbio.2021.06.016 UR - https://m2.mtmt.hu/api/publication/32310524 ID - 32310524 N1 - Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou, 510140, China Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Dhaka, 1000, Bangladesh Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, Fuzhou, 350117, China Department of Pathology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 21116, China Cited By :2 Export Date: 21 February 2022 Correspondence Address: Shubhra, Q.T.H.; Key Laboratory of Oral Medicine, China; email: shubhro.du@gmail.com Chemicals/CAS: arginylglycylaspartic acid, 99896-85-2; carbonyl reductase, 77106-95-7, 89700-36-7; doxorubicin, 23214-92-8, 25316-40-9; epigallocatechin gallate, 989-51-5; glucose oxidase, 9001-37-0; indocyanine green, 3599-32-4; polyglactin, 26780-50-7, 34346-01-5; Doxorubicin Funding details: Ministry of Science and Technology of the People's Republic of China, MOST, EAS-429 Funding details: Fujian Normal University Funding text 1: This work was supported by a grant from the Ministry of Science and Technology (EAS-429), Bangladesh. We are thankful to Dr. Xiao Nanyang of Fujian Normal University, China for his instrumental support. Funding text 2: This work was supported by a grant from the Ministry of Science and Technology ( EAS-429 ), Bangladesh. We are thankful to Dr. Xiao Nanyang of Fujian Normal University, China for his instrumental support. AB - This study first reports the development of a smart drug delivery system (DDS) for multimodal synergistic cancer therapy combining chemo-photothermal-starvation approaches. A magnetic photothermal agent was synthesized by preparing iron oxide (IO) nanoparticles (NPs) with covalently attached indocyanine green (ICG) and glucose oxidase (GOx) (ICGOx@IO). Synthesized ICGOx@IO NPs were coencapsulated with doxorubicin (Dox) and EGCG ((-)-epigallocatechin-3-gallate) inside PLGA (poly(lacticco-glycolic acid)) NPs using multiple emulsion solvent evaporation method. Such formulation gave the advantage of triggered drug release by near-infrared (NIR) laser irradiation (808 nm at 1 W/cm 2 ). RGD peptide was attached to the surface of PLGA NPs and the final hydrodynamic size was around 210 nm. Dual targeting by peptide and 240 mT external magnet significantly improved cellular uptake. Cellular uptake was observed using FACS, electron and optical microscopy. Dual targeting along with laser irradiation could reduce in vitro cell viability by 90 +/- 2% (Dox-equivalent dose: 10 mu g/ml) and complete tumor ablation was achieved in vivo due to synergetic therapeutic effect. Another attractive feature of the DDS was the significant reduction of cardiotoxicity of doxorubicin by EGCG. This new platform is thus expected to hold strong promise for future multimodal combination therapy of cancers. LA - English DB - MTMT ER - TY - JOUR AU - Fodorné Kardos, Andrea AU - Kiss, Ádám Ferenc AU - Monostory, Katalin AU - Feczkó, Tivadar TI - Sustained in vitro interferon-beta release and in vivo toxicity of PLGA and PEG-PLGA nanoparticles JF - RSC ADVANCES J2 - RSC ADV VL - 10 PY - 2020 SP - 15893 EP - 15900 PG - 8 SN - 2046-2069 DO - 10.1039/c9ra09928j UR - https://m2.mtmt.hu/api/publication/31287190 ID - 31287190 N1 - Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences Magyar Tudósok, Körútja 2, Budapest, H-1117, Hungary Research Institute of Biomolecular and Chemical Engineering, University of Pannonia, Egyetem u. 10, Veszprém, H-8200, Hungary Institute of Enzymology, Research Centre for Natural Sciences Magyar Tudósok, Körútja 2, Budapest, H-1117, Hungary Cited By :9 Export Date: 21 February 2022 CODEN: RSCAC Correspondence Address: Feczkó, T.; Institute of Materials and Environmental Chemistry, Körútja 2, Hungary; email: tivadar.feczko@gmail.com Funding details: Gedeon Richter, RG-IPI-2015-TP9/015 Funding text 1: The authors acknowledge the support of Gedeon Richter Plc. (reference: Richter 2015 RG-IPI-2015-TP9/015) and the BIONANO_GINOP-2.3.2-15-2016-00017 project. S/TEM studies were performed at the electron microscopy laboratory of the University of Pannonia, established using grant no. GINOP-2.3.3-15-2016-0009 from the European Structural and Investments Funds and the Hungarian Government. We thank Dr György Várady for the FACS measurements. LA - English DB - MTMT ER - TY - JOUR AU - dos Santos, Sandra Cruz AU - Silva, Nichole Osti AU - dos Santos Espinelli Junior, Joao Batista AU - Germani Marinho, Marcelo Augusto AU - Borges, Zeane Vieira AU - Caon Branco, Natalia Bruzamarello AU - Faita, Fabricio Luiz AU - Soares, Bruno Meira AU - Horn, Ana Paula AU - Parize, Alexandre Luis AU - de Lima, Vania Rodrigues TI - Molecular interactions and physico-chemical characterization of quercetin-loaded magnetoliposomes JF - CHEMISTRY AND PHYSICS OF LIPIDS J2 - CHEM PHYS LIPIDS VL - 218 PY - 2019 SP - 22 EP - 33 PG - 12 SN - 0009-3084 DO - 10.1016/j.chemphyslip.2018.11.010 UR - https://m2.mtmt.hu/api/publication/30992809 ID - 30992809 N1 - Environmental Chemistry and Technology Graduate Program, College of Chemistry and Food Science, Federal University of Rio Grande, Av. Itália km 8, Carreiros Campus, Rio Grande, RS 96201-900, Brazil Physiological Science Graduate Program, Biology Department, Federal University of Rio Grande, Av. Itália km 8, Carreiros Campus, Rio Grande, RS 96201-900, Brazil Science and Material Engineering Graduate Program, Mechanical Engineering Department, Federal University of Santa Catarina, Trindade Campus, P.O. Box 476, Florianópolis, SC 88040-900, Brazil Chemistry Department, Federal University of Santa Catarina, Trindade Campus, P.O. Box 476, Florianópolis, SC 88040-900, Brazil College of Physics, Federal University of Rio Grande do Sul, Porto Alegre, RS 91501-970, Brazil Cited By :10 Export Date: 21 February 2022 CODEN: CPLIA Correspondence Address: Rodrigues de Lima, V.; College of Chemistry and Food Science, Av. Itália, km 8, Carreiros Campus, Brazil; email: vrlima23@hotmail.com Chemicals/CAS: azolectin, 69279-91-0; ferric oxide, 1309-37-1, 56449-54-8; quercetin, 117-39-5; Antioxidants; Liposomes; Quercetin Funding details: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES Funding details: Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq Funding text 1: The authors would like to thank the Brazilian agencies Conselho de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for their financial support, as well as the Analytical Integrated Center (CIA)- FURG for 1 H NMR and 31 P NMR analyses. The authors would also like to thank ProfessorJoão Cardoso de Lima, Ph.D. (Laboratory of Material Synthesis and Characterization-LCSM) and the Multiuser Laboratory of Magnetic Characterization of Materials, both from the Physics Department of the Federal University of Santa Catarina, UFSC, SC, Brazil, for the DSC and VSM interpretations. The authors would also like to thank the Hydrochemistry Laboratory from the Institute of Oceanography (FURG) for sample preparations prior to FAAS. This paper is part of Sandra Cruz dos Santos’ doctoral thesis, which was carried out in the graduate program of Technological and Environmental Chemistry (FURG). AB - The bioflavonoid quercetin may prevent magnetoliposomes oxidation, preserving their stability. In this work, the interaction between quercetin and asolectin-based magnetoliposomes was investigated by monitoring the hydration degree, vibrational, rotational and translational mobility parameters of the system as well as its thermodynamic properties. The efficiency of the encapsulation of maghemite magnetic nanoparticles was detected by high resolution-continuum source flame atomic absorption spectrometry (HR-CS FAAS). The magnetic behavior of the system was studied by vibrating sample magnetometry (VSM) technique. The size and surface charge of magnetoliposomes were detected by dynamic light scattering (DLS) and zeta potential (zeta-potential) measurements. The influence of quercetin on the physico-chemical parameters of the magnetoliposomes was evaluated by Fourier transform infrared spectroscopy (FTIR), P-31 and H-1 nuclear magnetic resonance (NMR) and differential scanning calorimetry (DSC) techniques. In vitro antioxidant and antitumoral assays were also performed for the magnetoliposomes. An insertion of quercetin into magnetoliposomes reduced the efficiency of the encapsulation of maghemite nanoparticles by 11%, suggesting a significant interaction between flavonoid and nanoparticles in a specific region of the system. Quercetin discreetly decreased the saturation magnetization of magnetoliposomes, but did not affect the superparamagnetic behavior of the system. P-31 and H-1 NMR results showed that quercetin did not alter the inverted hexagonal system phase state but decreased lipid polar head mobility. The flavonoid also seems to reorient the choline group above the bilayer phosphate membrane plane, as indicated by zeta-potential system values. FTIR, NMR and DSC responses showed that quercetin disordered the carbonyl and the methylene regions of the magnetoliposomes. Quercetin, as the nanoparticles, seems to be located in the polar head regions of magnetoliposomes, ordering it and diminishing the lipid intermolecular communication in the membrane carbonyl and non-polar regions. The lipid peroxidation of the magnetoliposomes was prevented 8-fold by the presence of quercetin in the system. Also, the flavonoid was responsible for a 45% reduction in the viability of glioma cells. Location and interactions between quercetin and magnetoliposomes components were discussed in order to be correlated with the results of biological activity, contributing to the design of more stable and efficient magnetoliposomes to be applied as contrast and antitumoral agents. LA - English DB - MTMT ER - TY - JOUR AU - Saengruengrit, Chalathan AU - Ritprajak, Patcharee AU - Wanichwecharungruang, Supason AU - Sharma, Apoorva AU - Salvan, Georgeta AU - Zahn, Dietrich R. T. AU - Insin, Numpon TI - The combined magnetic field and iron oxide-PLGA composite particles: Effective protein antigen delivery and immune stimulation in dendritic cells JF - JOURNAL OF COLLOID AND INTERFACE SCIENCE J2 - J COLLOID INTERF SCI VL - 520 PY - 2018 SP - 101 EP - 111 PG - 11 SN - 0021-9797 DO - 10.1016/j.jcis.2018.03.008 UR - https://m2.mtmt.hu/api/publication/30448530 ID - 30448530 N1 - Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand Research Unit in Oral Microbiology and Immunology, Department of Microbiology, Faculty of Dentistry, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand Oral Biology Research Center, Faculty of Dentistry, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand Center of Excellence in Materials and Bio-interfaces, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok, 10330, Thailand Semiconductor Physics, Institute of Physics, Chemnitz University of Technology, Chemnitz, 09107, Germany Cited By :18 Export Date: 21 February 2022 CODEN: JCISA Correspondence Address: Insin, N.; Department of Chemistry, Thailand; email: Numpon.I@chula.ac.th Chemicals/CAS: gamma interferon, 82115-62-6; interleukin 12, 138415-13-1; oleic acid, 112-80-1, 115-06-0; polyglactin, 26780-50-7, 34346-01-5; ferric ion, 20074-52-6; ferric oxide, 1309-37-1, 56449-54-8; lactic acid, 113-21-3, 50-21-5; polyglycolic acid, 26009-03-0, 26124-68-5, 26202-08-4; Cytokines; Drug Carriers; Ferric Compounds; ferric oxide; Lactic Acid; Magnetite Nanoparticles; Polyglycolic Acid; polylactic acid-polyglycolic acid copolymer; Serum Albumin, Bovine Funding details: RES560530153-HR Funding details: Chulalongkorn University, CU Funding details: School of Aerospace Science and Technology Funding text 1: This work is supported by Ratchadaphiseksomphot Endowment Fund (RES560530153-HR). Staff mobility was carried out with funding from Grant for Join Funding, Ratchadapiseksomphot Endowment Fund. Saengruengrit C. is supported by Science Achievement Scholarship of Thailand (SAST), Chulalongkorn Graduate School, and the 90th Anniversary of Chulalongkorn University Fund. We thank Oral Biology Research Center, Faculty of Dentistry Chulalongkorn University for cell culture facility, flow cytometry service and equipment for biological research. Appendix A AB - Superparamagnetic iron oxide nanoparticles (SPIONs) have received much attention in drug and biomolecule delivery systems. Here, we report a delivery system using the combination of a magnetic field and the relatively biocompatible composite particles of poly(lactic-co-glycolic acid) and SPIONs (SPION-PLGA particles) for protein delivery to bone-marrow derived primary dendritic cells (BM-DCs). SPIONs with the diameter of similar to 10 nm were synthesized via thermal decomposition of iron(Ill) oleate. The SPIONs and bovine serum albumin (BSA) were encapsulated in PLGA particles of two different diameters, 300 and 500 nm. The obtained SPIONs-PLGA nanocomposites exhibited superparamagnetic character, showed low cytotoxicity and were well taken up in macrophage and BM-DCs under an external magnetic field. In addition, the nanocomposites were tested for immune induction in BM-DCs. This combined SPION-PLGA carrier and an external magnetic field can significantly enhance BM-DC maturation by upregulating MHC II, CD80 and CD86 expression. Immune response induction by this strategy is verified through a significant upregulation of the IL-12 and IFN-gamma production. Moreover, no activation of BM-DCs to secrete pro-inflammatory cytokine TNF-alpha was observed for all particles. We anticipate these findings to be a starting point for vaccine researches involving the combined magnetic field and SPION-PLGA composite particles. (C) 2018 Elsevier Inc. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Cricchio, V AU - Best, M AU - Reverchon, E AU - Maffulli, N AU - Phillips, G AU - Santin, M AU - Della Porta, G TI - Novel Superparamagnetic Microdevices Based on Magnetized PLGA/PLA Microparticles Obtained by Supercritical Fluid Emulsion and Coating by Carboxybetaine-Functionalized Chitosan Allowing the Tuneable Release of Therapeutics JF - JOURNAL OF PHARMACEUTICAL SCIENCES J2 - J PHARM SCI VL - 106 PY - 2017 IS - 8 SP - 2097 EP - 2105 PG - 9 SN - 0022-3549 DO - 10.1016/j.xphs.2017.05.005 UR - https://m2.mtmt.hu/api/publication/26880532 ID - 26880532 N1 - Supercritical Fluids Lab., Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, Fisciano, SA 84084, Italy Brighton Studies in Tissue-mimicry and Aided Regeneration (BrightSTAR), Brighton Centre for Regenerative Medicine (BCRM), University of Brighton, Huxley Building Lewes Road, Brighton, United Kingdom Translational Medicine Lab., Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, Baronissi, SA 84081, Italy Cited By :15 Export Date: 21 February 2022 CODEN: JPMSA Correspondence Address: Santin, M.United Kingdom Chemicals/CAS: chitosan, 9012-76-4; fluorescein, 2321-07-5, 91316-42-6; polyglactin, 26780-50-7, 34346-01-5; polylactic acid, 26100-51-6; betaine, 107-43-7, 590-46-5; lactic acid, 113-21-3, 50-21-5; polyglycolic acid, 26009-03-0, 26124-68-5, 26202-08-4; polylactide, 26680-10-4; Betaine; Chitosan; Delayed-Action Preparations; Emulsions; Fluorescent Dyes; Lactic Acid; Magnetite Nanoparticles; poly(lactide); Polyesters; Polyglycolic Acid; polylactic acid-polyglycolic acid copolymer LA - English DB - MTMT ER - TY - JOUR AU - Zhao, Chili AU - Han, Qiaorong AU - Qin, Hong AU - Yan, Hong AU - Qian, Zhilei AU - Ma, Zhenye AU - Zhang, Xia AU - Li, Xinghui TI - Biocompatible hyperbranched polyester magnetic nanocarrier for stimuli-responsive drug release JF - JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION J2 - J BIOMAT SCI-POLYM E VL - 28 PY - 2017 IS - 7 SP - 616 EP - 628 PG - 13 SN - 0920-5063 DO - 10.1080/09205063.2017.1289630 UR - https://m2.mtmt.hu/api/publication/26760657 ID - 26760657 N1 - School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, China Nanjing Chest Hospital, Nanjing, China Cited By :4 Export Date: 21 February 2022 CODEN: JBSEE Correspondence Address: Han, Q.; School of Chemistry and Materials Science, China; email: hanqiaorong@njnu.edu.cn Chemicals/CAS: isoniazid, 54-85-3, 62229-51-0, 65979-32-0; superparamagnetic iron oxide, 119683-68-0; succinic anhydride, 108-30-5; Biocompatible Materials; Drug Carriers; Isoniazid; Magnetite Nanoparticles; Polyesters; succinic anhydride; Succinic Anhydrides LA - English DB - MTMT ER - TY - JOUR AU - Feczko, Tivadar AU - Fodor-Kardos, Andrea AU - Sivakumaran, Muttuswamy AU - Shubhra, Quazi Tanminul Haque TI - In vitro IFN-alpha release from IFN-alpha- and pegylated IFN-alpha-loaded poly(lactic-co-glycolic acid) and pegylated poly(lactic-coglycolic acid) nanoparticles JF - NANOMEDICINE J2 - NANOMEDICINE-UK VL - 11 PY - 2016 IS - 16 SP - 2029 EP - 2034 PG - 6 SN - 1743-5889 DO - 10.2217/nnm-2016-0058 UR - https://m2.mtmt.hu/api/publication/26238512 ID - 26238512 LA - English DB - MTMT ER - TY - THES AU - Torres, Mendieta Rafael Omar TI - Synthesis of colloidal nanomaterials through femtosecond laser ablation PY - 2016 SP - 156 DO - 10.6035/14104.2016.518487 UR - https://m2.mtmt.hu/api/publication/26919191 ID - 26919191 N1 - Universitat Jaume I. Departament de Física LA - Spanish DB - MTMT ER - TY - JOUR AU - Alam, A K M Moshiul AU - Shubhra, Quazi T H TI - Surface modified thin film from silk and gelatin for sustained drug release to heal wound JF - JOURNAL OF MATERIALS CHEMISTRY B J2 - J MATER CHEM B VL - 3 PY - 2015 IS - 31 SP - 6473 EP - 6479 PG - 7 SN - 2050-750X DO - 10.1039/c5tb00920k UR - https://m2.mtmt.hu/api/publication/25081452 ID - 25081452 N1 - Cited By :16 Export Date: 21 February 2022 CODEN: JMCBD Correspondence Address: Shubhra, Q.T.H.; Institute of Radiation and Polymer Technology, Bangladesh LA - English DB - MTMT ER - TY - JOUR AU - Pandita, Deepti AU - Kumar, Sandeep AU - Lather, Viney TI - Hybrid poly(lactic-co-glycolic acid) nanoparticles: design and delivery prospectives JF - DRUG DISCOVERY TODAY J2 - DRUG DISCOV TODAY VL - 20 PY - 2015 IS - 1 SP - 95 EP - 104 PG - 10 SN - 1359-6446 DO - 10.1016/j.drudis.2014.09.018 UR - https://m2.mtmt.hu/api/publication/24782570 ID - 24782570 N1 - Department of Pharmaceutics, Jan Nayak Ch. Devi Lal Memorial College of Pharmacy, Sirsa, Haryana, 125055, India Department of Pharmaceutical Chemistry, Jan Nayak Ch. Devi Lal Memorial College of Pharmacy, Sirsa, Haryana, 125055, India Cited By :74 Export Date: 21 February 2022 CODEN: DDTOF Correspondence Address: Pandita, D.; Department of Pharmaceutics, Jan Nayak Ch. Devi Lal Memorial College of PharmacyIndia Chemicals/CAS: macrogol, 25322-68-3; polyglactin, 26780-50-7, 34346-01-5; lactic acid, 113-21-3, 50-21-5; polyglycolic acid, 26009-03-0, 26124-68-5, 26202-08-4; Lactic Acid; Polyglycolic Acid; polylactic acid-polyglycolic acid copolymer LA - English DB - MTMT ER - TY - JOUR AU - Pascolo, L AU - Bortot, B AU - Benseny-Cases, N AU - Gianoncelli, A AU - Tosi, G AU - Ruozi, B AU - Rizzardi, C AU - De Martino, E AU - Vandelli, MA AU - Severini, GM TI - Detection of PLGA-based nanoparticles at a single-cell level by synchrotron radiation FTIR spectromicroscopy and correlation with X-ray fluorescence microscopy JF - INTERNATIONAL JOURNAL OF NANOMEDICINE J2 - INT J NANOMED VL - 9 PY - 2014 IS - 1 SP - 2791 EP - 2801 PG - 11 SN - 1176-9114 DO - 10.2147/IJN.S58685 UR - https://m2.mtmt.hu/api/publication/24149467 ID - 24149467 N1 - Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico Burlo Garofolo, Trieste, Italy European Synchrotron Radiation Facility, Polygone Scientifique Louis Néel, Grenoble, France Elettra-Sincrotrone Trieste, Area Science Park, Basovizza, Trieste, Italy Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy Department of Anatomical Pathology, Department of Pathology and Forensic Medicine, University of Trieste, Trieste, Italy Cited By :22 Export Date: 21 February 2022 Correspondence Address: Severini, G. M.; Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico Burlo Garofolo, via dell'Istria 65/1, 34137 Trieste, Italy; email: severini@burlo.trieste.it Chemicals/CAS: iron, 14093-02-8, 53858-86-9, 7439-89-6; polyglactin, 26780-50-7, 34346-01-5; lactic acid, 113-21-3, 50-21-5; polyglycolic acid, 26009-03-0, 26124-68-5, 26202-08-4; Lactic Acid; Polyglycolic Acid; polylactic acid-polyglycolic acid copolymer LA - English DB - MTMT ER - TY - JOUR AU - Patel, Sulabh P AU - Vaishya, Ravi AU - Mishra, Gyan Prakash AU - Tamboli, Viral AU - Pal, Dhananjay AU - Mitra, Ashim K TI - Tailor-made pentablock copolymer based formulation for sustained ocular delivery of protein therapeutics JF - JOURNAL OF DRUG DELIVERY J2 - J DRUG DELIV VL - 2014 PY - 2014 PG - 15 SN - 2090-3014 UR - https://m2.mtmt.hu/api/publication/25882423 ID - 25882423 N1 - Volume 2014 (2014), Article ID 401747, 15 pages http://dx.doi.org/10.1155/2014/401747 LA - English DB - MTMT ER - TY - JOUR AU - Shubhra, Quazi Tanminul Haque AU - Tóth, Judit AU - Gyenis, János AU - Feczkó, Tivadar TI - Surface modification of HSA containing magnetic PLGA nanoparticles by poloxamer to decrease plasma protein adsorption JF - COLLOIDS AND SURFACES B: BIOINTERFACES J2 - COLLOID SURFACE B VL - 122 PY - 2014 SP - 529 EP - 536 PG - 8 SN - 0927-7765 DO - 10.1016/j.colsurfb.2014.07.025 UR - https://m2.mtmt.hu/api/publication/2822838 ID - 2822838 N1 - Doctoral School of Molecular and Nanotechnologies, Faculty of Information Technology, University of Pannonia, Egyetem u.10, Veszprém, H-8200, Hungary Research Institute of Chemical and Process Engineering, Faculty of Information Technology, University of Pannonia, Egyetem u.10, Veszprém, H-8200, Hungary Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Budapest, H-1117, Hungary Cited By :37 Export Date: 21 February 2022 CODEN: CSBBE Correspondence Address: Shubhra, Q.T.H.; Doctoral School of Molecular and Nanotechnologies, Faculty of Information Technology, University of Pannonia, Egyetem u.10, Hungary Chemicals/CAS: human serum albumin, 9048-49-1; poloxamer, 9003-11-6; polyglactin, 26780-50-7, 34346-01-5; lactic acid, 113-21-3, 50-21-5; polyglycolic acid, 26009-03-0, 26124-68-5, 26202-08-4; serum albumin, 9048-46-8; Lactic Acid; Polyglycolic Acid; polylactic acid-polyglycolic acid copolymer; Serum Albumin Funding details: European Commission, EC, 264722 Funding text 1: We thank Prof. Ferenc Vonderviszt for instrumental support in the ITC analysis. The authors acknowledge the financial support of the European Commission granted through the “PowTech” Marie Curie Initial Training Network (Grant Agreement No. 264722 ). LA - English DB - MTMT ER - TY - THES AU - Thasneem, YM TI - Designing of Biospecific Nanoparticles for Advanced Drug Delivery Applications PY - 2014 SP - 322 UR - https://m2.mtmt.hu/api/publication/25882426 ID - 25882426 N1 - SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY THIRUVANANTHAPURAM INDIA LA - English DB - MTMT ER - TY - THES AU - Patel, Sulabh P TI - Development of pentablock copolymer based formulations for the sustained delivery of protein therapeutics in the treatment of posterior segment ocular diseases PY - 2013 SP - 263 UR - https://m2.mtmt.hu/api/publication/25882434 ID - 25882434 N1 - A DISSERTATION IN Pharmaceutical Sciences and Chemistry Presented to the Faculty of University of Missouri Kansas City DOCTOR OF PHILOSOPHY LA - English DB - MTMT ER -