@article{MTMT:34607762, title = {Biocompatible nanocomposite scaffolds based on carrageenan incorporating hydroxyapatite and hesperidin loaded nanoparticles for bone tissue regeneration}, url = {https://m2.mtmt.hu/api/publication/34607762}, author = {Taymouri, Somayeh and Hasani, Faezeh and Mirian, Mina and Farhang, Armin and Varshosaz, Jaleh}, doi = {10.1002/pat.6284}, journal-iso = {POLYM ADVAN TECHNOL}, journal = {POLYMERS FOR ADVANCED TECHNOLOGIES}, volume = {35}, unique-id = {34607762}, issn = {1042-7147}, abstract = {In this study, injectable and osteoinductive carrageenan (CGN)-based composite hydrogel integrated with 1% wt/vol hydroxyapatite (HA) and hesperidin (HPN) loaded poly (3-hydroxybutyrate-co-3-hydroxyvalerate acid) nanoparticles (PHBV NPs) were developed as a scaffold for bone tissue engineering. Accordingly, HPN was encapsulated into PHBV NPs by the oil in water emulsion-solvent evaporation technique and optimized using the fractional factorial design. Then, the effects of the amount of drug, polymer, surfactant concentration, sonication time, and the water/organic phase volume ratio on the characteristics of NPs, including particle size (PS), polydispersity index (PdI), zeta potential (ZP), drug loading (DL) % and encapsulation efficiency (EE) % were investigated. The crystalline state of HPN and the interaction between the drug and the polymer were also investigated using the x-ray powder diffraction method and the Fourier transform infrared method, respectively. Further, CGN hydrogel was developed and loaded with optimized NPs and HA (HPN-PHBV NPs-CGN/HA hydrogel). The prepared hydrogel was then characterized for drug release, swelling and degradation behavior, mechanical properties, and injectability. In addition, the potential of the composite hydrogel as bone tissue scaffolds was assessed by the MTT assay, alkaline phosphatase (ALP) activity, and alizarin red S staining. The optimized formulation had the size of 353.5 nm, PdI of 0.43, EE% of 88.47%, DL% of 29.58% and the ZP of -17.4. HPN-PHBV NPs-CGN/HA hydrogel also showed sustained drug release, as compared to the HPN-CGN/HA hydrogel. Further, the hydrogel containing HA showed improved mechanical properties, as compared with the HA free one. In addition, HPN-PHBV NPs-CGN/HA hydrogel significantly enhanced MG63 cell proliferation, ALP activity and matrix mineralization, as compared with other groups. Overall, the use of this hydrogel with enhanced osteogenic capacity could be considered as an effective approach for bone tissue engineering.}, keywords = {hydroxyapatite; hesperidin; bone tissue engineering; Fractional factorial design; MG-63 cells; alkaline phosphatase assay}, year = {2024}, eissn = {1099-1581} } @article{MTMT:32636317, title = {Engineering polymer nanoparticles using cell membrane coating technology and their application in cancer treatments: Opportunities and challenges}, url = {https://m2.mtmt.hu/api/publication/32636317}, author = {Guo, K. and Xiao, N. and Liu, Y. and Wang, Z. and Tóth, Judit and Gyenis, János and Thakur, V.K. and Oyane, A. and Shubhra, Q.T.H.}, doi = {10.1016/j.nanoms.2021.12.001}, journal-iso = {NANO MATER SCI}, journal = {NANO MATERIALS SCIENCE}, volume = {4}, unique-id = {32636317}, issn = {2096-6482}, abstract = {Nanotechnology has revolutionized cancer drug delivery, and recent research continues to focus on the development of “one-size- fits-all,” i.e., “all-in-one” delivery nanovehicles. Although nanomedicines can address significant shortcomings of conventional therapy, biological barriers remain a challenge in their delivery and accumulation at diseased sites. To achieve long circulation time, immune evasion, and targeted accumulation, conventional nanocarriers need modifications, e.g., PEGylation, peptide/aptamer attachment, etc. One such modification is a biomimetic coating using cell membrane (CM), which can offer long circulation or targeting, or both. This top-down CM coating process is facile and can provide some advantageous features over surface modification by synthetic polymers. Herein, an overview is provided on the engineering of CM camouflaged polymer nanoparticles. A short section on CM and the development of CM coating technology has been provided. Detailed description of the preparation and characterization of CM camouflaged polymer NPs and their applications in cancer treatment has been reported. A brief comparison between CM coating and PEGylation has been highlighted. Various targeting approaches to achieve tumor-specific delivery of CM coated NPs have been summarized here. Overall, this review will give the readers a nice picture of CM coated polymer NPs, along with their opportunities and challenges. © 2021 Chongqing University}, keywords = {CELLS; CANCER; Cell Membrane; Cytology; NANOPARTICLES; DISEASES; nanoparticle; Drug delivery; Functional polymers; PEGylation; Biomimetics; Plastic coatings; Targeted drug delivery; Cell engineering; Controlled drug delivery; Polymer nanoparticles; Biomimetic coating; Biomimetic coating; camouflage; Natural polymers; Synthetic polymers; nanoparticles (NPs); Membrane coatings; Long circulations; Engineering polymers; Cell membrane (CM); Cancer drug deliveries; Coating technologies}, year = {2022}, eissn = {2589-9651}, pages = {295-321}, orcid-numbers = {Gyenis, János/0000-0001-5928-0535} } @article{MTMT:32692358, title = {Homotypic biomimetic coating synergizes chemo-photothermal combination therapy to treat breast cancer overcoming drug resistance}, url = {https://m2.mtmt.hu/api/publication/32692358}, author = {Guo, K. and Liu, Y. and Tang, L. and Shubhra, Q.T.H.}, doi = {10.1016/j.cej.2021.131120}, journal-iso = {CHEM ENG J}, journal = {CHEMICAL ENGINEERING JOURNAL}, volume = {428}, unique-id = {32692358}, issn = {1385-8947}, abstract = {Breast cancer (BC) is a leading cause of death in women worldwide and multidrug resistance (MDR) severely limits its treatment since chemotherapy is the standard approach for treating BCs. In this work, high biocompatibility resulted from biomimetic coating, magnetic and homotypic targeting plus triggered release properties were integrated in one smart drug delivery system (DDS) to overcome drug resistance and to achieve combination cancer therapy. MCF-7 cancer cell membrane coating was applied to chitosan-PLGA based DDS entrapping photothermal iron oxide nanoparticles (PIO NPs), Doxorubicin (Dox) and Mcl-1-siRNA. Such coating facilitated homotypic targeting of MCF-7/ADR cells, whereas PIO NPs facilitated magnetic targeting by the external magnetic field, thereby resulting in high in vitro cellular uptake and in vivo accumulation at the tumor site. Upon NIR (near-infrared) laser irradiation and at acidic pH, the DDS exhibited triggered release. The cytotoxicity of Dox on MCF-7 and MCF-7/ADR cells significantly improved by the developed DDS due to increased intracellular Dox accumulation. Application of NIR laser and external magnetic field resulted in maximum therapeutic outcome utilizing chemo-photothermal combination and the DDS was able to inhibit almost 80% tumor growth in MCF-7/ADR tumor model. This new nanoplatform holds strong promise in BC therapy and can be exploited to treat other cancers. © 2021 Elsevier B.V.}, keywords = {CANCER; CHEMOTHERAPY; TUMORS; Cytology; COATINGS; Drug Resistance; DISEASES; magnetic fields; doxorubicin; DRUG-RESISTANCE; breast cancer; biocompatibility; Infrared devices; DRUG-DELIVERY SYSTEMS; Biomimetics; Iron oxides; Targeted drug delivery; Controlled drug delivery; Photo-thermal; Biomimetic coating; Biomimetic coating; Triggered release; Homotypic targeting; Homotypic targeting; smart drug delivery system; Chemo-photothermal combination therapy; Chemo-photothermal combination therapy; Smart drug delivery systems}, year = {2022}, eissn = {1873-3212} } @article{MTMT:32998172, title = {Enhanced drug release from a pH-responsive nanocarrier can augment colon cancer treatment by blocking PD-L1 checkpoint and consuming tumor glucose}, url = {https://m2.mtmt.hu/api/publication/32998172}, author = {Guo, Kai and Liu, Yixuan and Ding, Min and Sun, Qi and Shubhra, Quazi T. H.}, doi = {10.1016/j.matdes.2022.110824}, journal-iso = {MATER DESIGN}, journal = {MATERIALS AND DESIGN}, volume = {219}, unique-id = {32998172}, issn = {0264-1275}, abstract = {In this study, it was aimed to exploit no chemical drug to treat cancer by starvation-immunotherapy combination. We used PD-L1 siRNA to down-regulate checkpoint protein PD-L1 on cancer cell surfaces, and IFN-gamma was used as an immunomodulatory agent to activate the innate immune system. When PD-L1 siRNA, IFN-gamma, and glucose oxidase (GOx) were co-delivered to the tumor microenvironment (TME) by a pH-sensitive drug delivery system (DDS), starvation-immunotherapy combinedly resulted in significant tumor volume reduction in a mouse model. The DDS was prepared by using PLGA polymer whose surface was coated with chitosan. IFN-gamma, siRNA, and GOx entrapment efficiencies were 93.5 +/- 3.1%, 65.1 +/- 2.6%, and 66.2 +/- 3.3%, respectively. Moreover, the size of the DDS was well below 200 nm, allowing easy sterilization and tumor accumulation by the enhanced permeability and retention (EPR) effect. In vitro pH-dependent release study indicated that in acidic pH, the developed DDS can show accelerated drug release. In a mouse model and in acidic TME, the DDS resulted in the best therapeutic effect due to pH-dependent drug release compared to unmodified DDS and free drug. Our findings reflect that high efficiency in colon cancer treatment is achieved by combination therapy over the studied monotherapies. (C) 2022 The Authors. Published by Elsevier Ltd.}, keywords = {cancer immunotherapy; T cell; glucose oxidase; nanocarrier; IMMUNE ACTIVATION; checkpoint inhibition}, year = {2022}, eissn = {1873-4197} } @article{MTMT:33218516, title = {Engineered Magnetic Polymer Nanoparticles Can Ameliorate Breast Cancer Treatment Inducing Pyroptosis-Starvation along with Chemotherapy}, url = {https://m2.mtmt.hu/api/publication/33218516}, author = {Liu, Yixuan and Guo, Kai and Ding, Min and Zhang, Bingchen and Xiao, Nanyang and Tang, Zonghao and Wang, Zhengming and Zhang, Chengfei and Shubhra, Quazi T. H.}, doi = {10.1021/acsami.2c13011}, journal-iso = {ACS APPL MATER INTER}, journal = {ACS APPLIED MATERIALS & INTERFACES}, volume = {14}, unique-id = {33218516}, issn = {1944-8244}, abstract = {Nanotechnology has shown a revolution in cancer treatments, including breast cancers. However, there remain some challenges and translational hurdles. Surgery, radiotherapy, and chemotherapy are the primary treatment methods for breast cancer, although drug combinations showed promising results in preclinical studies. Herein we report the development of a smart drug delivery system (DDS) to efficiently treat breast cancer by pyroptosis-starvation-chemotherapeutic combination. Cancer-starvation agent glucose oxidase was chemically attached to synthesized iron oxide nanoparticles which were entrapped inside poly(lactic-co-glycolic acid) along with apoptosis-associated speck-like protein containing a caspase recruitment domain plasmid and paclitaxel (PTX). An emulsion solvent evaporation method was used to prepare the DDS. The surface of the DDS was modified with chitosan to which aptamer was attached to achieve site-specific targeting. Hence, the prepared DDS could be targeted to a tumor site by both external magnet and aptamer to obtain an enhanced accumulation of drugs at the tumor site. The final size of the aptamer-decorated DDS was less than 200 nm, and the encapsulation efficiency of PTX was 76.5 +/- 2.5%. Drug release from the developed DDS was much higher at pH 5.5 than at pH 7.4, ensuring the pH sensitivity of the DDS. Due to efficient dual targeting of the DDS, in vitro viability of 4T1 cells was reduced to 12.1 +/- 1.6%, whereas the nontargeted group and free PTX group could reduce the viability of cells to 29.2 +/- 2.4 and 46.2 +/- 1.6%, respectively. Our DDS showed a synergistic effect in vitro and no severe side effects in vivo. This DDS has strong potential to treat various cancers.}, keywords = {glucose oxidase; Pyroptosis; pH-responsive drug release; cancer-starvation therapy; combination cancer treatment}, year = {2022}, eissn = {1944-8252}, pages = {42541-42557} } @article{MTMT:32692593, title = {Optimization of hemoglobin encapsulation within plga nanoparticles and their investigation as potential oxygen carriers}, url = {https://m2.mtmt.hu/api/publication/32692593}, author = {Coll-Satue, C. and Jansman, M.M.T. and Thulstrup, P.W. and Hosta-Rigau, L.}, doi = {10.3390/pharmaceutics13111958}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {13}, unique-id = {32692593}, issn = {1999-4923}, abstract = {Hemoglobin (Hb)-based oxygen carriers (HBOCs) display the excellent oxygen-carrying properties of red blood cells, while overcoming some of the limitations of donor blood. Various encapsulation platforms have been explored to prepare HBOCs which aim to avoid or minimize the adverse effects caused by the administration of free Hb. Herein, we entrapped Hb within a poly(lac-tide-co-glycolide) (PLGA) core, prepared by the double emulsion solvent evaporation method. We study the effect of the concentrations of Hb, PLGA, and emulsifier on the size, polydispersity (PDI), loading capacity (LC), and entrapment efficiency (EE) of the resulting Hb-loaded PLGA nanoparti-cles (HbNPs). Next, the ability of the HbNPs to reversibly bind and release oxygen was thoroughly evaluated. When needed, trehalose, a well-known protein stabilizer that has never been explored for the fabrication of HBOCs, was incorporated to preserve Hb’s functionality. The optimized formulation had a size of 344 nm, a PDI of 0.172, a LC of 26.9%, and an EE of 40.7%. The HbNPs were imaged by microscopy and were further characterized by FTIR and CD spectroscopy to assess their chemical composition and structure. Finally, the ability of the encapsulated Hb to bind and release oxygen over several rounds was demonstrated, showing the preservation of its functionality. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.}, keywords = {Protein Stability; Blood Substitutes; biomedicine; trehalose; PLGA nanoparticles; Nanocarriers; hemoglobin-based oxygen carriers; Double emulsification; Smart nanomaterials}, year = {2021}, eissn = {1999-4923} } @article{MTMT:32310524, title = {Dual targeting smart drug delivery system for multimodal synergistic combination cancer therapy with re duce d cardiotoxicity}, url = {https://m2.mtmt.hu/api/publication/32310524}, author = {Shubhra, Quazi T. H. and Guo, Kai and Liu, Yixuan and Razzak, Md and Manir, Md Serajum and Alam, A. K. M. Moshiul}, doi = {10.1016/j.actbio.2021.06.016}, journal-iso = {ACTA BIOMATER}, journal = {ACTA BIOMATERIALIA}, volume = {131}, unique-id = {32310524}, issn = {1742-7061}, abstract = {This study first reports the development of a smart drug delivery system (DDS) for multimodal synergistic cancer therapy combining chemo-photothermal-starvation approaches. A magnetic photothermal agent was synthesized by preparing iron oxide (IO) nanoparticles (NPs) with covalently attached indocyanine green (ICG) and glucose oxidase (GOx) (ICGOx@IO). Synthesized ICGOx@IO NPs were coencapsulated with doxorubicin (Dox) and EGCG ((-)-epigallocatechin-3-gallate) inside PLGA (poly(lacticco-glycolic acid)) NPs using multiple emulsion solvent evaporation method. Such formulation gave the advantage of triggered drug release by near-infrared (NIR) laser irradiation (808 nm at 1 W/cm 2 ). RGD peptide was attached to the surface of PLGA NPs and the final hydrodynamic size was around 210 nm. Dual targeting by peptide and 240 mT external magnet significantly improved cellular uptake. Cellular uptake was observed using FACS, electron and optical microscopy. Dual targeting along with laser irradiation could reduce in vitro cell viability by 90 +/- 2% (Dox-equivalent dose: 10 mu g/ml) and complete tumor ablation was achieved in vivo due to synergetic therapeutic effect. Another attractive feature of the DDS was the significant reduction of cardiotoxicity of doxorubicin by EGCG. This new platform is thus expected to hold strong promise for future multimodal combination therapy of cancers.}, keywords = {CANCER; cardiotoxicity; dual targeting; smart drug delivery system; Magnetic photothermal nanoparticles; Chemo-photothermal-starvation combination therapy}, year = {2021}, eissn = {1878-7568}, pages = {493-507}, orcid-numbers = {Shubhra, Quazi T. H./0000-0003-4791-2763; Guo, Kai/0000-0002-4291-4439} } @article{MTMT:31287190, title = {Sustained in vitro interferon-beta release and in vivo toxicity of PLGA and PEG-PLGA nanoparticles}, url = {https://m2.mtmt.hu/api/publication/31287190}, author = {Fodorné Kardos, Andrea and Kiss, Ádám Ferenc and Monostory, Katalin and Feczkó, Tivadar}, doi = {10.1039/c9ra09928j}, journal-iso = {RSC ADV}, journal = {RSC ADVANCES}, volume = {10}, unique-id = {31287190}, issn = {2046-2069}, year = {2020}, eissn = {2046-2069}, pages = {15893-15900} } @article{MTMT:30992809, title = {Molecular interactions and physico-chemical characterization of quercetin-loaded magnetoliposomes}, url = {https://m2.mtmt.hu/api/publication/30992809}, author = {dos Santos, Sandra Cruz and Silva, Nichole Osti and dos Santos Espinelli Junior, Joao Batista and Germani Marinho, Marcelo Augusto and Borges, Zeane Vieira and Caon Branco, Natalia Bruzamarello and Faita, Fabricio Luiz and Soares, Bruno Meira and Horn, Ana Paula and Parize, Alexandre Luis and de Lima, Vania Rodrigues}, doi = {10.1016/j.chemphyslip.2018.11.010}, journal-iso = {CHEM PHYS LIPIDS}, journal = {CHEMISTRY AND PHYSICS OF LIPIDS}, volume = {218}, unique-id = {30992809}, issn = {0009-3084}, abstract = {The bioflavonoid quercetin may prevent magnetoliposomes oxidation, preserving their stability. In this work, the interaction between quercetin and asolectin-based magnetoliposomes was investigated by monitoring the hydration degree, vibrational, rotational and translational mobility parameters of the system as well as its thermodynamic properties. The efficiency of the encapsulation of maghemite magnetic nanoparticles was detected by high resolution-continuum source flame atomic absorption spectrometry (HR-CS FAAS). The magnetic behavior of the system was studied by vibrating sample magnetometry (VSM) technique. The size and surface charge of magnetoliposomes were detected by dynamic light scattering (DLS) and zeta potential (zeta-potential) measurements. The influence of quercetin on the physico-chemical parameters of the magnetoliposomes was evaluated by Fourier transform infrared spectroscopy (FTIR), P-31 and H-1 nuclear magnetic resonance (NMR) and differential scanning calorimetry (DSC) techniques. In vitro antioxidant and antitumoral assays were also performed for the magnetoliposomes. An insertion of quercetin into magnetoliposomes reduced the efficiency of the encapsulation of maghemite nanoparticles by 11%, suggesting a significant interaction between flavonoid and nanoparticles in a specific region of the system. Quercetin discreetly decreased the saturation magnetization of magnetoliposomes, but did not affect the superparamagnetic behavior of the system. P-31 and H-1 NMR results showed that quercetin did not alter the inverted hexagonal system phase state but decreased lipid polar head mobility. The flavonoid also seems to reorient the choline group above the bilayer phosphate membrane plane, as indicated by zeta-potential system values. FTIR, NMR and DSC responses showed that quercetin disordered the carbonyl and the methylene regions of the magnetoliposomes. Quercetin, as the nanoparticles, seems to be located in the polar head regions of magnetoliposomes, ordering it and diminishing the lipid intermolecular communication in the membrane carbonyl and non-polar regions. The lipid peroxidation of the magnetoliposomes was prevented 8-fold by the presence of quercetin in the system. Also, the flavonoid was responsible for a 45% reduction in the viability of glioma cells. Location and interactions between quercetin and magnetoliposomes components were discussed in order to be correlated with the results of biological activity, contributing to the design of more stable and efficient magnetoliposomes to be applied as contrast and antitumoral agents.}, keywords = {Quercetin; HYPERTHERMIA; Maghemite; Magnetoliposomes; Asolectin}, year = {2019}, eissn = {1873-2941}, pages = {22-33} } @article{MTMT:30448530, title = {The combined magnetic field and iron oxide-PLGA composite particles: Effective protein antigen delivery and immune stimulation in dendritic cells}, url = {https://m2.mtmt.hu/api/publication/30448530}, author = {Saengruengrit, Chalathan and Ritprajak, Patcharee and Wanichwecharungruang, Supason and Sharma, Apoorva and Salvan, Georgeta and Zahn, Dietrich R. T. and Insin, Numpon}, doi = {10.1016/j.jcis.2018.03.008}, journal-iso = {J COLLOID INTERF SCI}, journal = {JOURNAL OF COLLOID AND INTERFACE SCIENCE}, volume = {520}, unique-id = {30448530}, issn = {0021-9797}, abstract = {Superparamagnetic iron oxide nanoparticles (SPIONs) have received much attention in drug and biomolecule delivery systems. Here, we report a delivery system using the combination of a magnetic field and the relatively biocompatible composite particles of poly(lactic-co-glycolic acid) and SPIONs (SPION-PLGA particles) for protein delivery to bone-marrow derived primary dendritic cells (BM-DCs). SPIONs with the diameter of similar to 10 nm were synthesized via thermal decomposition of iron(Ill) oleate. The SPIONs and bovine serum albumin (BSA) were encapsulated in PLGA particles of two different diameters, 300 and 500 nm. The obtained SPIONs-PLGA nanocomposites exhibited superparamagnetic character, showed low cytotoxicity and were well taken up in macrophage and BM-DCs under an external magnetic field. In addition, the nanocomposites were tested for immune induction in BM-DCs. This combined SPION-PLGA carrier and an external magnetic field can significantly enhance BM-DC maturation by upregulating MHC II, CD80 and CD86 expression. Immune response induction by this strategy is verified through a significant upregulation of the IL-12 and IFN-gamma production. Moreover, no activation of BM-DCs to secrete pro-inflammatory cytokine TNF-alpha was observed for all particles. We anticipate these findings to be a starting point for vaccine researches involving the combined magnetic field and SPION-PLGA composite particles. (C) 2018 Elsevier Inc. All rights reserved.}, keywords = {VACCINE; immune response; PLGA; Iron oxide superparamagnetic nanoparticles; Protein antigen delivery; Primary dendritic cell}, year = {2018}, eissn = {1095-7103}, pages = {101-111} } @article{MTMT:26880532, title = {Novel Superparamagnetic Microdevices Based on Magnetized PLGA/PLA Microparticles Obtained by Supercritical Fluid Emulsion and Coating by Carboxybetaine-Functionalized Chitosan Allowing the Tuneable Release of Therapeutics}, url = {https://m2.mtmt.hu/api/publication/26880532}, author = {Cricchio, V and Best, M and Reverchon, E and Maffulli, N and Phillips, G and Santin, M and Della Porta, G}, doi = {10.1016/j.xphs.2017.05.005}, journal-iso = {J PHARM SCI}, journal = {JOURNAL OF PHARMACEUTICAL SCIENCES}, volume = {106}, unique-id = {26880532}, issn = {0022-3549}, year = {2017}, eissn = {1520-6017}, pages = {2097-2105} } @article{MTMT:26760657, title = {Biocompatible hyperbranched polyester magnetic nanocarrier for stimuli-responsive drug release}, url = {https://m2.mtmt.hu/api/publication/26760657}, author = {Zhao, Chili and Han, Qiaorong and Qin, Hong and Yan, Hong and Qian, Zhilei and Ma, Zhenye and Zhang, Xia and Li, Xinghui}, doi = {10.1080/09205063.2017.1289630}, journal-iso = {J BIOMAT SCI-POLYM E}, journal = {JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION}, volume = {28}, unique-id = {26760657}, issn = {0920-5063}, year = {2017}, eissn = {1568-5624}, pages = {616-628} } @article{MTMT:26238512, title = {In vitro IFN-alpha release from IFN-alpha- and pegylated IFN-alpha-loaded poly(lactic-co-glycolic acid) and pegylated poly(lactic-coglycolic acid) nanoparticles}, url = {https://m2.mtmt.hu/api/publication/26238512}, author = {Feczko, Tivadar and Fodor-Kardos, Andrea and Sivakumaran, Muttuswamy and Shubhra, Quazi Tanminul Haque}, doi = {10.2217/nnm-2016-0058}, journal-iso = {NANOMEDICINE-UK}, journal = {NANOMEDICINE}, volume = {11}, unique-id = {26238512}, issn = {1743-5889}, year = {2016}, eissn = {1748-6963}, pages = {2029-2034} } @mastersthesis{MTMT:26919191, title = {Synthesis of colloidal nanomaterials through femtosecond laser ablation}, url = {https://m2.mtmt.hu/api/publication/26919191}, author = {Torres, Mendieta Rafael Omar}, doi = {10.6035/14104.2016.518487}, unique-id = {26919191}, year = {2016} } @article{MTMT:25081452, title = {Surface modified thin film from silk and gelatin for sustained drug release to heal wound}, url = {https://m2.mtmt.hu/api/publication/25081452}, author = {Alam, A K M Moshiul and Shubhra, Quazi T H}, doi = {10.1039/c5tb00920k}, journal-iso = {J MATER CHEM B}, journal = {JOURNAL OF MATERIALS CHEMISTRY B}, volume = {3}, unique-id = {25081452}, issn = {2050-750X}, year = {2015}, eissn = {2050-7518}, pages = {6473-6479} } @article{MTMT:24782570, title = {Hybrid poly(lactic-co-glycolic acid) nanoparticles: design and delivery prospectives}, url = {https://m2.mtmt.hu/api/publication/24782570}, author = {Pandita, Deepti and Kumar, Sandeep and Lather, Viney}, doi = {10.1016/j.drudis.2014.09.018}, journal-iso = {DRUG DISCOV TODAY}, journal = {DRUG DISCOVERY TODAY}, volume = {20}, unique-id = {24782570}, issn = {1359-6446}, year = {2015}, eissn = {1878-5832}, pages = {95-104} } @article{MTMT:24149467, title = {Detection of PLGA-based nanoparticles at a single-cell level by synchrotron radiation FTIR spectromicroscopy and correlation with X-ray fluorescence microscopy}, url = {https://m2.mtmt.hu/api/publication/24149467}, author = {Pascolo, L and Bortot, B and Benseny-Cases, N and Gianoncelli, A and Tosi, G and Ruozi, B and Rizzardi, C and De Martino, E and Vandelli, MA and Severini, GM}, doi = {10.2147/IJN.S58685}, journal-iso = {INT J NANOMED}, journal = {INTERNATIONAL JOURNAL OF NANOMEDICINE}, volume = {9}, unique-id = {24149467}, issn = {1176-9114}, year = {2014}, eissn = {1178-2013}, pages = {2791-2801} } @article{MTMT:25882423, title = {Tailor-made pentablock copolymer based formulation for sustained ocular delivery of protein therapeutics}, url = {https://m2.mtmt.hu/api/publication/25882423}, author = {Patel, Sulabh P and Vaishya, Ravi and Mishra, Gyan Prakash and Tamboli, Viral and Pal, Dhananjay and Mitra, Ashim K}, journal-iso = {J DRUG DELIV}, journal = {JOURNAL OF DRUG DELIVERY}, volume = {2014}, unique-id = {25882423}, issn = {2090-3014}, year = {2014}, eissn = {2090-3022} } @article{MTMT:2822838, title = {Surface modification of HSA containing magnetic PLGA nanoparticles by poloxamer to decrease plasma protein adsorption}, url = {https://m2.mtmt.hu/api/publication/2822838}, author = {Shubhra, Quazi Tanminul Haque and Tóth, Judit and Gyenis, János and Feczkó, Tivadar}, doi = {10.1016/j.colsurfb.2014.07.025}, journal-iso = {COLLOID SURFACE B}, journal = {COLLOIDS AND SURFACES B: BIOINTERFACES}, volume = {122}, unique-id = {2822838}, issn = {0927-7765}, year = {2014}, eissn = {1873-4367}, pages = {529-536}, orcid-numbers = {Gyenis, János/0000-0001-5928-0535} } @mastersthesis{MTMT:25882426, title = {Designing of Biospecific Nanoparticles for Advanced Drug Delivery Applications}, url = {https://m2.mtmt.hu/api/publication/25882426}, author = {Thasneem, YM}, unique-id = {25882426}, year = {2014} } @mastersthesis{MTMT:25882434, title = {Development of pentablock copolymer based formulations for the sustained delivery of protein therapeutics in the treatment of posterior segment ocular diseases}, url = {https://m2.mtmt.hu/api/publication/25882434}, author = {Patel, Sulabh P}, unique-id = {25882434}, year = {2013} }