@article{MTMT:33887202, title = {Macrophages CD163+and Factor XIIIa plus Provide a First-Line Defence against Proliferative Verrucous Leukoplakia Antigens}, url = {https://m2.mtmt.hu/api/publication/33887202}, author = {Palacon, Mariana Paravani and Barbeiro, Camila de Oliveira and Fernandes, Darcy and Biancardi, Mariel Ruivo and Silveira, Heitor Albergoni and Ferrisse, Tulio Morandin and Leon, Jorge Esquiche and Kujan, Omar and Bufalino, Andreia}, doi = {10.3390/ijms24065242}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {33887202}, issn = {1661-6596}, abstract = {This study aimed to evaluate the density of the dendritic cells (DCs) and macrophages in oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL) by immunohistochemical analysis. We analysed paraffined tissue samples of PVL (n = 27), OL (n = 20), and inflammatory fibrous hyperplasia (n = 20) as the control group using the immunomarkers for DCs (CD1a, CD207, CD83, CD208 and CD123) and macrophages (CD68, CD163, FXIIIa and CD209). A quantitative analysis of positive cells in the epithelial and subepithelial areas was determined. Our results showed a reduction in CD208+ cells in the subepithelial area of the OL and PVL compared to the control. Additionally, we found a higher density of FXIIIa+ and CD163+ cells in the subepithelial area in PVL compared to the OL and control. Four-way MANOVA revealed a relationship between increased CD123+ cell density in the subepithelial area of "high-risk" samples regardless of disease. Macrophages provide the first line of defence against PVL antigens, suggesting a distinct pattern of innate immune system activation in PVL compared to OL, which may contribute to the complexity and the high rate of malignant transformation in the PVL.}, keywords = {MACROPHAGES; DENDRITIC CELLS; malignant transformation; Oral; PROLIFERATIVE VERRUCOUS LEUKOPLAKIA}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Leon, Jorge Esquiche/0000-0002-9668-5870; Kujan, Omar/0000-0002-5951-8280} } @article{MTMT:31848446, title = {Factor XIII-A in Diseases: Role Beyond Blood Coagulation}, url = {https://m2.mtmt.hu/api/publication/31848446}, author = {Dull, Katalin and Fazekas, Fruzsina and Törőcsik, Dániel}, doi = {10.3390/ijms22031459}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {22}, unique-id = {31848446}, issn = {1661-6596}, year = {2021}, eissn = {1422-0067} } @article{MTMT:32894638, title = {Multiple roles of macrophage in skin}, url = {https://m2.mtmt.hu/api/publication/32894638}, author = {Nakai, K.}, doi = {10.1016/j.jdermsci.2021.08.008}, journal-iso = {J DERMATOL SCI}, journal = {JOURNAL OF DERMATOLOGICAL SCIENCE}, volume = {104}, unique-id = {32894638}, issn = {0923-1811}, abstract = {More than 100 years have passed since Elie Metchnikoff discovered macrophage. Over the recent decade, attracting information about macrophage polarization have been reported. This is because many molecules have been identified as markers of macrophage polarization. Additionally, mechanistic insights have been demonstrated by experiments with various stimuli-induced macrophage polarization. Historically and simply, macrophages are divided into M1 (classically activated) and M2 (alternatively activated). However, some of them are not specific yet. Studies in the field of cardiology revealed the plasticity of macrophages and their subsets are divided into details: Mhem, MHb, Mox and M4 macrophages. M2 macrophages were further divided in M2a, M2b, M2c and M2d. There appears to be more phenotypes of macrophages. However, there still lack studies in dermatological field. This review summarizes the spectrum of macrophage activation and finding about various roles of macrophages in the dermatological field. © 2021}, keywords = {Animals; Humans; MACROPHAGES; SKIN; SKIN; SKIN; SKIN; immunology; review; human; animal; Cell Differentiation; Cell Differentiation; MACROPHAGE; MACROPHAGE; Cytology; pathology; Macrophage Activation; Macrophage Activation; Macrophage Activation; POLARIZATION; POLARIZATION; human cell; Cardiology; Skin diseases; skin disease; cell plasticity; cell plasticity; M2 macrophage}, year = {2021}, eissn = {1873-569X}, pages = {2-10} } @article{MTMT:30967582, title = {Infliximab reduces activated myeloid dendritic cells, different macrophage subsets and CXCR3-positive cells in granuloma annulare}, url = {https://m2.mtmt.hu/api/publication/30967582}, author = {Buergler, Christina and Vinay, Keshavamurthy and Haefliger, Stefanie and Kloetgen, Hans-Wilhelm and Yawalkar, Nikhil}, doi = {10.1111/1346-8138.14981}, journal-iso = {J DERMATOL}, journal = {JOURNAL OF DERMATOLOGY}, volume = {46}, unique-id = {30967582}, issn = {0385-2407}, abstract = {Disseminated granuloma annulare (GA) is a rare granulomatous dermatitis of unknown etiology. Treatment is often challenging and lack of a uniformly effective treatment, adds to the disease morbidity. Tumor necrosis factor (TNF)-alpha is an important cytokine in granuloma formation and previous reports have shown improvement of disseminated GA with anti-TNF-alpha therapy. Nevertheless, the underlying mechanism of actions of TNF-alpha inhibitors in GA remains unclear. Our aim was to evaluate alterations in the inflammatory infiltrate in a patient who experienced complete clearance of GA after treatment with infliximab. A skin biopsy was obtained before and 24 weeks after treatment with infliximab 5 mg/kg at weeks 0, 2, 6, 14 and 24. Immunohistochemical stains were performed in pre- and post-treatment biopsy specimens using CD1a, CD4, CD8, CD11c, CD32, CD68, CD69, CD163, CD183 and human leukocyte antigen (HLA)-DR to characterize alterations of the infiltrates. Parallel with clinical improvement, we observed a marked decrease in myeloid (CD11c) dendritic cells, different macrophage subsets (CD68, CD32, CD163) and T cells. In addition, a marked reduction of activation markers (HLA-DR, CD69) and CD183(+) (CXCR3) cells was observed in post-treatment biopsy specimens. In conclusion, the clinical improvement of disseminated GA by infliximab is paralleled by inhibition of activated myeloid dendritic cells, different macrophage subsets and type 1 T cells.}, keywords = {MACROPHAGES; DENDRITIC CELLS; infliximab; T cells; granuloma annulare}, year = {2019}, eissn = {1346-8138}, pages = {808-811}, orcid-numbers = {Vinay, Keshavamurthy/0000-0001-6323-4988} } @article{MTMT:30967583, title = {Localized Perforating Granuloma Annulare}, url = {https://m2.mtmt.hu/api/publication/30967583}, author = {Pap, Nives and Bradamante, Mirna and Hadzavdic, Suzana Ljubojevic}, journal-iso = {ACTA DERMATOVENER CR}, journal = {ACTA DERMATOVENEROLOGICA CROATICA}, volume = {27}, unique-id = {30967583}, issn = {1330-027X}, abstract = {Perforating granuloma annulare (PGA) is a rare type of granulomatous skin disease. The etiology and pathogenesis of PGA are still unknown. Diagnosis and treatment of PGA is complex and challenging. We present the case of a 31-year-old male patient with a localized form of PGA successfully treated with topical steroids.}, keywords = {granuloma; perforating granuloma annulare; localized granuloma annulare}, year = {2019}, eissn = {1847-6538}, pages = {33-36} } @article{MTMT:27613525, title = {The C-Type Lectin Receptor DC-SIGN Has an Anti-Inflammatory Role in Human M(IL-4) Macrophages in Response to Mycobacterium tuberculosis}, url = {https://m2.mtmt.hu/api/publication/27613525}, author = {Lugo-Villarino, Geanncarlo and Troegeler, Anthony and Balboa, Luciana and Lastrucci, Claire and Duval, Carine and Mercier, Ingrid and Benard, Alan and Capilla, Florence and Al, Saati Talal and Poincloux, Renaud and Kondova, Ivanela and Verreck, Frank A W and Cougoule, Celine and Maridonneau-Parini, Isabelle and Sasiain, Maria del Carmen and Neyrolles, Olivier}, doi = {10.3389/fimmu.2018.01123}, journal-iso = {FRONT IMMUNOL}, journal = {FRONTIERS IN IMMUNOLOGY}, volume = {9}, unique-id = {27613525}, issn = {1664-3224}, year = {2018}, eissn = {1664-3224}, orcid-numbers = {Maridonneau-Parini, Isabelle/0000-0003-0189-0976} } @article{MTMT:26562207, title = {What is new in the histogenesis of granulomatous skin diseases?}, url = {https://m2.mtmt.hu/api/publication/26562207}, author = {Asai, Jun}, doi = {10.1111/1346-8138.13662}, journal-iso = {J DERMATOL}, journal = {JOURNAL OF DERMATOLOGY}, volume = {44}, unique-id = {26562207}, issn = {0385-2407}, year = {2017}, eissn = {1346-8138}, pages = {297-303} } @article{MTMT:3244185, title = {Sebum lipids influence macrophage polarization and activation.}, url = {https://m2.mtmt.hu/api/publication/3244185}, author = {Lovászi, Marianna and Mattii, M and Eyerich, K and Gácsi, Attila and Csányi, Erzsébet and Kovács, Dóra and Ruhl, R and Szegedi, Andrea and Kemény, Lajos and Stahle, M and Zouboulis, CC and Eyerich, S and Törőcsik, Dániel}, doi = {10.1111/bjd.15754}, journal-iso = {BRIT J DERMATOL}, journal = {BRITISH JOURNAL OF DERMATOLOGY}, volume = {177}, unique-id = {3244185}, issn = {0007-0963}, abstract = {BACKGROUND: As lipids are known to regulate macrophage functions it is reasonable to suppose that a sebocyte - macrophage axis mediated by sebum lipids may exist. OBJECTIVE: To investigate if sebocytes could contribute to the differentiation, polarization and function of macrophages with their secreted lipids. METHODS: Oil-red-O lipid staining and Raman spectroscopy were used to assess the dermal lipid content and penetration. Immunohistochemistry was used to analyse the macrophage subsets. Human peripheral blood monocytes were differentiated in the presence of either supernatant from human SZ95 sebocytes or major sebum lipid components and activated with Propionibacterium acnes. Macrophage surface markers and their capacity to uptake FITC-Propionibacterium acnes were detected by FACS measurements. Cytokine protein levels were evaluated by ELISA and Western blot analysis. RESULTS: Sebaceous gland rich skin had an increased dermal lipid content compared to sebaceous gland poor skin to which all the tested sebum component lipids could contribute by penetrating through the dermo-epidermal barrier. Of the lipids, oleic and linoleic acids promoted monocyte differentiation into alternatively activated macrophages. Moreover, linoleic acid also had an anti-inflammatory effect in Propionibacterium acnes activated macrophages, inhibiting the secretion of IL-1B, IL-6 and TNF-Alpha. Squalene, palmitic, stearic and oleic acids augmented the secretion of IL-1B even in the absence of Propionibacterium acnes, while oleic acid had a selective effect of inducing IL-1B, but down-regulating IL-6 and TNF-A secretion. CONCLUSIONS: Our results suggest a role for sebaceous glands in modulating innate immune responses via their secreted lipids that are of possible pathologic and therapeutic relevance. This article is protected by copyright. All rights reserved.}, year = {2017}, eissn = {1365-2133}, pages = {1671-1682}, orcid-numbers = {Lovászi, Marianna/0000-0002-1353-5317; Csányi, Erzsébet/0000-0002-3010-1959; Kemény, Lajos/0000-0002-2119-9501} } @article{MTMT:3345044, title = {Factor XIII Subunit A in the Skin: Applications in Diagnosis and Treatment}, url = {https://m2.mtmt.hu/api/publication/3345044}, author = {Paragh, L and Törőcsik, Dániel}, doi = {10.1155/2017/3571861}, journal-iso = {BIOMED RES INT}, journal = {BIOMED RESEARCH INTERNATIONAL}, volume = {2017}, unique-id = {3345044}, issn = {2314-6133}, abstract = {The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on the still controversial interpretation of dermal cell types expressing FXIII-A and assess the previously described mechanisms behind their accumulation under physiological and pathological conditions of the human skin. We summarize the intracellular functions of FXIII-A as well as its possible sources in the extracellular space of the dermis with a focus on its relevance to skin homeostasis and disease pathogenesis. Finally, the potential role of FXIII-A in wound healing, as a field with long-term therapeutic implications, is also discussed.}, year = {2017}, eissn = {2314-6141} } @article{MTMT:26824715, title = {Dendritic cell subsets in asthma: Impaired Tolerance or exaggerated inflammation?}, url = {https://m2.mtmt.hu/api/publication/26824715}, author = {Vroman, H and Hendriks, RW and Kool, M}, doi = {10.3389/fimmu.2017.00941}, journal-iso = {FRONT IMMUNOL}, journal = {FRONTIERS IN IMMUNOLOGY}, volume = {8}, unique-id = {26824715}, issn = {1664-3224}, year = {2017}, eissn = {1664-3224} } @article{MTMT:26215576, title = {Systemic and intestinal levels of factor XIII-A: the impact of inflammation on expression in macrophage subtypes}, url = {https://m2.mtmt.hu/api/publication/26215576}, author = {Soendergaard, Christoffer and Kvist, Peter Helding and Seidelin, Jakob Benedict and Pelzer, Hermann and Nielsen, Ole Haagen}, doi = {10.1007/s00535-015-1152-2}, journal-iso = {J GASTROENTEROL}, journal = {JOURNAL OF GASTROENTEROLOGY}, volume = {51}, unique-id = {26215576}, issn = {0944-1174}, year = {2016}, eissn = {1435-5922}, pages = {796-807}, orcid-numbers = {Nielsen, Ole Haagen/0000-0003-4612-8635} } @article{MTMT:32894640, title = {Perforating granuloma annulare — an unusual subtype of a common disease}, url = {https://m2.mtmt.hu/api/publication/32894640}, author = {Alves, J. and Barreiros, H. and Bártolo, E.}, doi = {10.3390/healthcare2030338}, journal-iso = {HEALTHCARE-BASEL}, journal = {HEALTHCARE}, volume = {2}, unique-id = {32894640}, abstract = {Perforating granuloma annulare (GA) is a rare subset of GA with an unknown etiology and chronic course. Herein, we report the case of 72 year-old women with a 3-month history of a post-traumatic, persistent, erythematous and exudative plaque located on her left leg. Differential diagnosis included mycobacterial infection, subcutaneous mycosis, perforating dermatoses, pyoderma and squamous cell carcinoma. The histopathology was highly suggestive of a perforating GA. The patient was treated with betamethasone dipropionate cream applied once daily and a complete resolution of the lesion was observed in three weeks. Despite being a very rare subtype of a common disease, perforating granuloma annulare has clinical and histopathological characteristic features that facilitate the differential diagnosis, avoiding unnecessary procedures and inadequate and potentially more invasive treatments. © 2014 by the authors; licensee MDPI, Basel, Switzerland.}, keywords = {granuloma; granuloma annulare; Perforating GA}, year = {2014}, eissn = {2227-9032}, pages = {338-345} } @article{MTMT:24590645, title = {Dendritic cells: Phenotypic and functional heterogeneity}, url = {https://m2.mtmt.hu/api/publication/24590645}, author = {Silvano, A}, doi = {10.13128/IJAE-15563}, journal-iso = {ITAL J ANAT EMBRYOL}, journal = {ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY = ARCHIVIO ITALIANO DI ANATOMIA}, volume = {119}, unique-id = {24590645}, issn = {1122-6714}, year = {2014}, eissn = {2038-5129}, pages = {304-330} }