@article{MTMT:31868486,
	title = {Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila},
	url = {https://m2.mtmt.hu/api/publication/31868486},
	author = {Bjedov, I. and Cochemé, H.M. and Foley, A. and Wieser, D. and Woodling, N.S. and Castillo-Quan, J.I. and Norvaisas, P. and Lujan, C. and Regan, J. and Toivonen, J.M. and Murphy, M.P. and Thornton, J. and Kinghorn, K.J. and Neufeld, T.P. and Cabreiro, F. and Partridge, L.},
	doi = {10.1371/journal.pgen.1009083},
	journal-iso = {PLOS GENET},
	journal = {PLOS GENETICS},
	volume = {16},
	unique-id = {31868486},
	issn = {1553-7390},
	abstract = {Increased cellular degradation by autophagy is a feature of many interventions that delay ageing. We report here that increased autophagy is necessary for reduced insulin-like signalling (IIS) to extend lifespan in Drosophila and is sufficient on its own to increase lifespan. We first established that the well-characterised lifespan extension associated with deletion of the insulin receptor substrate chico was completely abrogated by downregulation of the essential autophagy gene Atg5. We next directly induced autophagy by over-expressing the major autophagy kinase Atg1 and found that a mild increase in autophagy extended lifespan. Interestingly, strong Atg1 up-regulation was detrimental to lifespan. Transcriptomic and metabolomic approaches identified specific signatures mediated by varying levels of autophagy in flies. Transcriptional upregulation of mitochondrial-related genes was the signature most specifically associated with mild Atg1 upregulation and extended lifespan, whereas short-lived flies, possessing strong Atg1 overexpression, showed reduced mitochondrial metabolism and up-regulated immune system pathways. Increased proteasomal activity and reduced triacylglycerol levels were features shared by both moderate and high Atg1 overexpression conditions. These contrasting effects of autophagy on ageing and differential metabolic profiles highlight the importance of fine-tuning autophagy levels to achieve optimal healthspan and disease prevention. © 2020 Bjedov et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.},
	year = {2020},
	eissn = {1553-7404}
}

@article{MTMT:27523506,
	title = {Antiviral Immune Response and the Route of Infection in Drosophila melanogaster},
	url = {https://m2.mtmt.hu/api/publication/27523506},
	author = {Mondotte, Juan A and Saleh, Maria-Carla},
	doi = {10.1016/bs.aivir.2017.10.006},
	journal-iso = {ADV VIRUS RES},
	journal = {ADVANCES IN VIRUS RESEARCH},
	volume = {100},
	unique-id = {27523506},
	issn = {0065-3527},
	year = {2018},
	eissn = {1557-8399},
	pages = {247-278},
	orcid-numbers = {Saleh, Maria-Carla/0000-0001-8593-4117}
}

@article{MTMT:3045263,
	title = {The raspberry Gene Is Involved in the Regulation of the Cellular Immune Response in Drosophila melanogaster},
	url = {https://m2.mtmt.hu/api/publication/3045263},
	author = {Kari, Beáta and Csordás, Gábor and Honti, Viktor and Cinege, Gyöngyi Ilona and Williams, MJ and Andó, István and Kurucz, Judit Éva},
	doi = {10.1371/journal.pone.0150910},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {11},
	unique-id = {3045263},
	issn = {1932-6203},
	abstract = {Drosophila is an extremely useful model organism for understanding how innate immune mechanisms defend against microbes and parasitoids. Large foreign objects trigger a potent cellular immune response in Drosophila larva. In the case of endoparasitoid wasp eggs, this response includes hemocyte proliferation, lamellocyte differentiation and eventual encapsulation of the egg. The encapsulation reaction involves the attachment and spreading of hemocytes around the egg, which requires cytoskeletal rearrangements, changes in adhesion properties and cell shape, as well as melanization of the capsule. Guanine nucleotide metabolism has an essential role in the regulation of pathways necessary for this encapsulation response. Here, we show that the Drosophila inosine 5'-monophosphate dehydrogenase (IMPDH), encoded by raspberry (ras), is centrally important for a proper cellular immune response against eggs from the parasitoid wasp Leptopilina boulardi. Notably, hemocyte attachment to the egg and subsequent melanization of the capsule are deficient in hypomorphic ras mutant larvae, which results in a compromised cellular immune response and increased survival of the parasitoid.},
	keywords = {PHAGOCYTOSIS; INHIBITORS; ACTIVATION; SCREEN; RHO; Hematopoiesis; INOSINE MONOPHOSPHATE DEHYDROGENASE; Parasitoids; SMALL GTPASES; LEPTOPILINA-BOULARDI},
	year = {2016},
	eissn = {1932-6203},
	orcid-numbers = {Csordás, Gábor/0000-0001-6871-6839; Andó, István/0000-0002-4648-9396}
}

@article{MTMT:24356213,
	title = {Methods to study Drosophila immunity},
	url = {https://m2.mtmt.hu/api/publication/24356213},
	author = {Neyen, C and Bretscher, AJ and Binggeli, O and Lemaitre, B},
	doi = {10.1016/j.ymeth.2014.02.023},
	journal-iso = {METHODS},
	journal = {METHODS},
	volume = {68},
	unique-id = {24356213},
	issn = {1046-2023},
	year = {2014},
	eissn = {1095-9130},
	pages = {116-128}
}