TY - JOUR AU - Dai, Zhiyun AU - Song, Luping AU - Luo, Chongjing AU - Liu, Di AU - Li, Mingyang AU - Han, Zaizhu TI - Hemispheric lateralization of language processing: insights from network-based symptom mapping and patient subgroups JF - CEREBRAL CORTEX J2 - CEREB CORTEX PY - 2023 PG - 21 SN - 1047-3211 DO - 10.1093/cercor/bhad437 UR - https://m2.mtmt.hu/api/publication/34604553 ID - 34604553 N1 - Export Date: 28 February 2024; CODEN: CECOE AB - The hemispheric laterality of language processing has become a hot topic in modern neuroscience. Although most previous studies have reported left-lateralized language processing, other studies found it to be bilateral. A previous neurocomputational model has proposed a unified framework to explain that the above discrepancy might be from healthy and patient individuals. This model posits an initial symmetry but imbalanced capacity in language processing for healthy individuals, with this imbalance contributing to language recovery disparities following different hemispheric injuries. The present study investigated this model by analyzing the lateralization patterns of language subnetworks across multiple attributes with a group of 99 patients (compared to nonlanguage processing) and examining the lateralization patterns of language subnetworks in subgroups with damage to different hemispheres. Subnetworks were identified using a whole-brain network-based lesion-symptom mapping method, and the lateralization index was quantitatively measured. We found that all the subnetworks in language processing were left-lateralized, while subnetworks in nonlanguage processing had different lateralization patterns. Moreover, diverse hemisphere-injury subgroups exhibited distinct language recovery effects. These findings provide robust support for the proposed neurocomputational model of language processing. LA - English DB - MTMT ER - TY - JOUR AU - Perez, Diana C. AU - Dworetsky, Ally AU - Braga, Rodrigo M. AU - Beeman, Mark AU - Gratton, Caterina TI - Hemispheric Asymmetries of Individual Differences in Functional Connectivity JF - JOURNAL OF COGNITIVE NEUROSCIENCE J2 - J COGNITIVE NEUROSCI VL - 35 PY - 2023 IS - 2 SP - 200 EP - 225 PG - 26 SN - 0898-929X DO - 10.1162/jocn_a_01945 UR - https://m2.mtmt.hu/api/publication/33617745 ID - 33617745 N1 - Funding Agency and Grant Number: National Institutes of Health [T32NS047987, 4R00MH117226, R01MH118370] Funding text: Diana C. Perez, National Institutes of Health (https://dx.doi .org/10.13039/100000002), grant number: T32NS047987. Rodrigo M. Braga, National Institutes of Health (https://dx.doi.org/10.13039/100000002), grant number: 4R00MH117226. Caterina Gratton, National Institutes of Health (https://dx.doi.org/10.13039/100000002), grant number: R01MH118370. AB - Resting-state fMRI studies have revealed that individuals exhibit stable, functionally meaningful divergences in large-scale network organization. The locations with strongest deviations (called network "variants") have a characteristic spatial distribution, with qualitative evidence from prior reports suggesting that this distribution differs across hemispheres. Hemispheric asymmetries can inform us on constraints guiding the development of these idiosyncratic regions. Here, we used data from the Human Connectome Project to systematically investigate hemispheric differences in network variants. Variants were significantly larger in the right hemisphere, particularly along the frontal operculum and medial frontal cortex. Variants in the left hemisphere appeared most commonly around the TPJ. We investigated how variant asymmetries vary by functional network and how they compare with typical network distributions. For some networks, variants seemingly increase group-average network asymmetries (e.g., the group-average language network is slightly bigger in the left hemisphere and variants also appeared more frequently in that hemisphere). For other networks, variants counter the group-average network asymmetries (e.g., the default mode network is slightly bigger in the left hemisphere, but variants were more frequent in the right hemisphere). Intriguingly, left- and right-handers differed in their network variant asymmetries for the cingulo-opercular and frontoparietal networks, suggesting that variant asymmetries are connected to lateralized traits. These findings demonstrate that idiosyncratic aspects of brain organization differ systematically across the hemispheres. We discuss how these asymmetries in brain organization may inform us on developmental constraints of network variants and how they may relate to functions differentially linked to the two hemispheres. LA - English DB - MTMT ER - TY - JOUR AU - Chen, Yu-Chi AU - Arnatkeviciute, Aurina AU - McTavish, Eugene AU - Pang, James C. AU - Chopra, Sidhant AU - Suo, Chao AU - Fornito, Alex AU - Aquino, Kevin M. AU - Initiative, Alzheimer's Disease Neuroimaging TI - The individuality of shape asymmetries of the human cerebral cortex JF - ELIFE J2 - ELIFE VL - 11 PY - 2022 PG - 28 SN - 2050-084X DO - 10.7554/eLife.75056 UR - https://m2.mtmt.hu/api/publication/33618853 ID - 33618853 N1 - Funding Agency and Grant Number: Sylvia and Charles Viertel Charitable Foundation; National Health and Medical Research Council; Australian Research Council; [1197431]; [1146292]; [DP200103509] Funding text: Sylvia and Charles Viertel Charitable Foundation Senior Medical Research Fellowship Alex Fornito National Health and Medical Research Council 1197431 Alex Fornito National Health and Medical Research Council 1146292 Alex Fornito Australian Research Council DP200103509 Alex Fornito The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. AB - Asymmetries of the cerebral cortex are found across diverse phyla and are particularly pronounced in humans, with important implications for brain function and disease. However, many prior studies have confounded asymmetries due to size with those due to shape. Here, we introduce a novel approach to characterize asymmetries of the whole cortical shape, independent of size, across different spatial frequencies using magnetic resonance imaging data in three independent datasets. We find that cortical shape asymmetry is highly individualized and robust, akin to a cortical fingerprint, and identifies individuals more accurately than size-based descriptors, such as cortical thickness and surface area, or measures of inter-regional functional coupling of brain activity. Individual identifiability is optimal at coarse spatial scales (similar to 37 mm wavelength), and shape asymmetries show scale-specific associations with sex and cognition, but not handedness. While unihemispheric cortical shape shows significant heritability at coarse scales (similar to 65 mm wavelength), shape asymmetries are determined primarily by subject-specific environmental effects. Thus, coarse-scale shape asymmetries are highly personalized, sexually dimorphic, linked to individual differences in cognition, and are primarily driven by stochastic environmental influences. LA - English DB - MTMT ER - TY - JOUR AU - Spironelli, Chiara AU - Borella, Erika TI - Working Memory Training and Cortical Arousal in Healthy Older Adults: A Resting-State EEG Pilot Study JF - FRONTIERS IN AGING NEUROSCIENCE J2 - FRONT AGING NEUROSCI VL - 13 PY - 2021 PG - 12 SN - 1663-4365 DO - 10.3389/fnagi.2021.718965 UR - https://m2.mtmt.hu/api/publication/32706762 ID - 32706762 N1 - Funding Agency and Grant Number: MIUR (Dipartimenti di Eccellenza)Ministry of Education, Universities and Research (MIUR) [DM 11/05/2017, 262]; Department of General Psychology, University of Padova; University of Padova [CPDA152872] Funding text: Funding This work was funded by a grant from MIUR (Dipartimenti di Eccellenza DM 11/05/2017 no. 262) to the Department of General Psychology, University of Padova, and by the PRAT 2015 grant from the University of Padova, project no. CPDA152872 to CS. AB - The current pilot study aimed to test the gains of working memory (WM) training, both at the short- and long-term, at a behavioral level, and by examining the electrophysiological changes induced by training in resting-state EEG activity among older adults. The study group included 24 older adults (from 64 to 75 years old) who were randomly assigned to a training group (TG) or an active control group (ACG) in a double-blind, repeated-measures experimental design in which open eyes, resting-state EEG recording, followed by a WM task, i.e., the Categorization Working Memory Span (CWMS) task, were collected before and after training, as well as at a 6-month follow-up session. At the behavioral level, medium to large Cohen's d effect sizes was found for the TG in immediate and long-term gains in the WM criterion task, as compared with small gains for the ACG. Regarding intrusion errors committed in the CWMS, an index of inhibitory control representing a transfer effect, results showed that medium to large effect sizes for immediate and long-term gains emerged for the TG, as compared to small effect sizes for the ACG. Spontaneous high-beta/alpha ratio analyses in four regions of interest (ROIs) revealed no pre-training group differences. Significantly greater TG anterior rates, particularly in the left ROI, were found after training, with frontal oscillatory responses being correlated with better post-training CWMS performance in only the TG. The follow-up analysis showed similar results, with greater anterior left high-beta/alpha rates among TG participants. Follow-up frontal high-beta/alpha rates in the right ROI were correlated with lower CWMS follow-up intrusion errors in only the TG. The present findings are further evidence of the efficacy of WM training in enhancing the cognitive functioning of older adults and their frontal oscillatory activity. Overall, these results suggested that WM training also can be a promising approach toward fostering the so-called functional cortical plasticity in aging. LA - English DB - MTMT ER - TY - JOUR AU - Zoli, Matteo AU - Talozzi, Lia AU - Martinoni, Matteo AU - Manners, David N. AU - Badaloni, Filippo AU - Testa, Claudia AU - Asioli, Sofia AU - Mitolo, Micaela AU - Bartiromo, Fiorina AU - Rochat, Magali Jane AU - Fabbri, Viscardo Paolo AU - Sturiale, Carmelo AU - Conti, Alfredo AU - Lodi, Raffaele AU - Mazzatenta, Diego AU - Tonon, Caterina TI - From Neurosurgical Planning to Histopathological Brain Tumor Characterization: Potentialities of Arcuate Fasciculus Along-Tract Diffusion Tensor Imaging Tractography Measures JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 12 PY - 2021 PG - 16 SN - 1664-2295 DO - 10.3389/fneur.2021.633209 UR - https://m2.mtmt.hu/api/publication/32186804 ID - 32186804 N1 - Pituitary Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy Neurosurgery Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy Department of Physics and Astronomy, University of Bologna, Bologna, Italy Anatomic Pathology Unit, Azienda USL di Bologna, Bologna, Italy Functional and Molecular Neuroimaging Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy Export Date: 9 September 2021 Correspondence Address: Mazzatenta, D.; Pituitary Unit, Italy; email: diego.mazzatenta@unibo.it Correspondence Address: Mazzatenta, D.; Department of Biomedical and Neuromotor Sciences, Italy; email: diego.mazzatenta@unibo.it AB - Background: Tractography has been widely adopted to improve brain gliomas' surgical planning and guide their resection. This study aimed to evaluate state-of-the-art of arcuate fasciculus (AF) tractography for surgical planning and explore the role of along-tract analyses in vivo for characterizing tumor histopathology. Methods: High angular resolution diffusion imaging (HARDI) images were acquired for nine patients with tumors located in or near language areas (age: 41 +/- 14 years, mean +/- standard deviation; five males) and 32 healthy volunteers (age: 39 +/- 16 years; 16 males). Phonemic fluency task fMRI was acquired preoperatively for patients. AF tractography was performed using constrained spherical deconvolution diffusivity modeling and probabilistic fiber tracking. Along-tract analyses were performed, dividing the AF into 15 segments along the length of the tract defined using the Laplacian operator. For each AF segment, diffusion tensor imaging (DTI) measures were compared with those obtained in healthy controls (HCs). The hemispheric laterality index (LI) was calculated from language task fMRI activations in the frontal, parietal, and temporal lobe parcellations. Tumors were grouped into low/high grade (LG/HG). Results: Four tumors were LG gliomas (one dysembryoplastic neuroepithelial tumor and three glioma grade II) and five HG gliomas (two grade III and three grade IV). For LG tumors, gross total removal was achieved in all but one case, for HG in two patients. Tractography identified the AF trajectory in all cases. Four along-tract DTI measures potentially discriminated LG and HG tumor patients (false discovery rate < 0.1): the number of abnormal MD and RD segments, median AD, and MD measures. Both a higher number of abnormal AF segments and a higher AD and MD measures were associated with HG tumor patients. Moreover, correlations (unadjusted p < 0.05) were found between the parietal lobe LI and the DTI measures, which discriminated between LG and HG tumor patients. In particular, a more rightward parietal lobe activation (LI < 0) correlated with a higher number of abnormal MD segments (R = -0.732) and RD segments (R = -0.724). Conclusions: AF tractography allows to detect the course of the tract, favoring the safer-as-possible tumor resection. Our preliminary study shows that along-tract DTI metrics can provide useful information for differentiating LG and HG tumors during pre-surgical tumor characterization. LA - English DB - MTMT ER - TY - JOUR AU - Packheiser, Julian AU - Schmitz, Judith AU - Arning, Larissa AU - Beste, Christian AU - Guentuerkuen, Onur AU - Ocklenburg, Sebastian TI - A large-scale estimate on the relationship between language and motor lateralization JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 10 PY - 2020 IS - 1 PG - 10 SN - 2045-2322 DO - 10.1038/s41598-020-70057-3 UR - https://m2.mtmt.hu/api/publication/31424638 ID - 31424638 N1 - Funding Agency and Grant Number: Deutsche Forschungsgemeinschaft through the Research Training Group "Situated Cognition"German Research Foundation (DFG) [GRK 2185/1]; DFG Open Access Funds of the Ruhr-Universitat Bochum Funding text: This study was supported by the Deutsche Forschungsgemeinschaft through the Research Training Group "Situated Cognition" (GRK 2185/1). We acknowledge support by the DFG Open Access Funds of the Ruhr-Universitat Bochum. Department of Biopsychology, Institute for Cognitive Neuroscience, Ruhr University Bochum, Universitätsstraße 150, Bochum, 44780, Germany School of Medicine, University of St Andrews, St Andrews, United Kingdom Department of Human Genetics, Ruhr University Bochum, Bochum, Germany Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany Department of Psychology, University of Duisburg-Essen, Essen, Germany Cited By :7 Export Date: 9 September 2021 Correspondence Address: Packheiser, J.; Department of Biopsychology, Universitätsstraße 150, Germany; email: julian.packheiser@rub.de AB - Human language is dominantly processed in the left cerebral hemisphere in most of the population. While several studies have suggested that there are higher rates of atypical right-hemispheric language lateralization in left-/mixed-handers, an accurate estimate of this association from a large sample is still missing. In this study, we comprised data from 1,554 individuals sampled in three previous studies in which language lateralization measured via dichotic listening, handedness and footedness were assessed. Overall, we found a right ear advantage indicating typical left-hemispheric language lateralization in 82.1% of the participants. While we found significantly more left-handed individuals with atypical language lateralization on the categorical level, we only detected a very weak positive correlation between dichotic listening lateralization quotients (LQs) and handedness LQs using continuous measures. Here, only 0.4% of the variance in language lateralization were explained by handedness. We complemented these analyses with Bayesian statistics and found no evidence in favor of the hypothesis that language lateralization and handedness are related. Footedness LQs were not correlated with dichotic listening LQs, but individuals with atypical language lateralization also exhibited higher rates of atypical footedness on the categorical level. We also found differences in the extent of language lateralization between males and females with males exhibiting higher dichotic listening LQs indicating more left-hemispheric language processing. Overall, these findings indicate that the direct associations between language lateralization and motor asymmetries are much weaker than previously assumed with Bayesian correlation analyses even suggesting that they do not exist at all. Furthermore, sex differences seem to be present in language lateralization when the power of the study is adequate suggesting that endocrinological processes might influence this phenotype. LA - English DB - MTMT ER - TY - GEN AU - Booth, Danny TI - Empirical Evidence and the Multiple Realization of Mental Kinds PY - 2018 UR - https://m2.mtmt.hu/api/publication/27461822 ID - 27461822 N1 - idéző Cím: Empirical Evidence and the Multiple Realization of Mental Kinds idéző Megjelenés éve: 2018 LA - English DB - MTMT ER - TY - JOUR AU - Heikkila, Kauko AU - Van, Beijsterveldt Catharina E M AU - Haukka, Jan AU - Iivanainen, Matti AU - Saari-Kemppainen, Aulikki AU - Silventoinen, Karri AU - Boomsma, Dorret I AU - Yokoyama, Yoshie AU - Vuoksimaa, Eero TI - Triplets, birthweight, and handedness JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 115 PY - 2018 IS - 23 SP - 6076 EP - 6081 PG - 6 SN - 0027-8424 DO - 10.1073/pnas.1719567115 UR - https://m2.mtmt.hu/api/publication/27462223 ID - 27462223 N1 - Funding Agency and Grant Number: Japan Society for the Promotion of Science [15H05105]; Netherlands Organization for Scientific Research (NWO) [NWO 480-15-001/674]; Royal Netherlands Academy of Science Professor Award [PAH/6635]; NWO [575-25-006, 480-04-004, 904-61-090, 904-61-193, 400-05-717, 311-60008, SPI 56-464-14192]; Avera Institute for Human Genetics\n Funding text: We warmly thank all triplet families for their participation. Japan: West Japan Twins and Higher Order Multiple Births Registry is supported by Grant-in-Aid for Scientific Research (B) (Grant 15H05105) from the Japan Society for the Promotion of Science. NTR: We gratefully acknowledge the Netherlands Organization for Scientific Research (NWO) for Grant NWO 480-15-001/674: Netherlands Twin Registry Repository: researching the interplay between genome and environment and the Royal Netherlands Academy of Science Professor Award (PAH/6635) (to D.I.B.). Data collection and zygosity typing were made possible by multiple grants from the NWO: 575-25-006, 480-04-004, 904-61-090, 904-61-193, 400-05-717, 311-60008, SPI 56-464-14192, and the Avera Institute for Human Genetics.\n \n Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, 00014, Finland \n Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, 1081 BT, Netherlands \n Department of Public Health, University of Helsinki, Helsinki, 00014, Finland \n Department of Child Neurology, University of Helsinki, Helsinki, 00014, Finland \n Helsinki University Hospital Gynecology and Obstetrics, Jorvi Hospital, Helsinki University Central Hospital, Espoo, 00029, Finland \n Population Research Unit, Department of Social Research, University of Helsinki, Helsinki, 00014, Finland \n Department of Public Health Nursing, Osaka City University, Osaka, 545-0051, Japan \n Cited By :1 \n Export Date: 26 November 2018 \n CODEN: PNASA \n Correspondence Address: Heikkilä, K.; Institute for Molecular Medicine Finland, University of HelsinkiFinland; email: kauko.heikkila@helsinki.fi Funding Agency and Grant Number: Japan Society for the Promotion of ScienceMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [15H05105]; Netherlands Organization for Scientific Research (NWO)Netherlands Organization for Scientific Research (NWO) [NWO 480-15-001/674]; Royal Netherlands Academy of Science Professor Award [PAH/6635]; NWONetherlands Organization for Scientific Research (NWO) [575-25-006, 480-04-004, 904-61-090, 904-61-193, 400-05-717, 311-60008, SPI 56-464-14192]; Avera Institute for Human Genetics Funding text: We warmly thank all triplet families for their participation. Japan: West Japan Twins and Higher Order Multiple Births Registry is supported by Grant-in-Aid for Scientific Research (B) (Grant 15H05105) from the Japan Society for the Promotion of Science. NTR: We gratefully acknowledge the Netherlands Organization for Scientific Research (NWO) for Grant NWO 480-15-001/674: Netherlands Twin Registry Repository: researching the interplay between genome and environment and the Royal Netherlands Academy of Science Professor Award (PAH/6635) (to D.I.B.). Data collection and zygosity typing were made possible by multiple grants from the NWO: 575-25-006, 480-04-004, 904-61-090, 904-61-193, 400-05-717, 311-60008, SPI 56-464-14192, and the Avera Institute for Human Genetics. Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, 00014, Finland Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, 1081 BT, Netherlands Department of Public Health, University of Helsinki, Helsinki, 00014, Finland Department of Child Neurology, University of Helsinki, Helsinki, 00014, Finland Helsinki University Hospital Gynecology and Obstetrics, Jorvi Hospital, Helsinki University Central Hospital, Espoo, 00029, Finland Population Research Unit, Department of Social Research, University of Helsinki, Helsinki, 00014, Finland Department of Public Health Nursing, Osaka City University, Osaka, 545-0051, Japan Cited By :10 Export Date: 9 September 2021 CODEN: PNASA Correspondence Address: Heikkilä, K.; Institute for Molecular Medicine Finland, Finland; email: kauko.heikkila@helsinki.fi AB - The mechanisms behind handedness formation in humans are still poorly understood. Very low birthweight is associated with higher odds of left-handedness, but whether this is due to low birthweight itself or premature birth is unknown. Handedness has also been linked to development, but the role of birthweight behind this association is unclear. Knowing that birthweight is lower in multiple births, triplets being about 1.5 kg lighter in comparison with singletons, and that multiples have a higher prevalence of left-handedness than singletons, we studied the association between birthweight and handedness in two large samples consisting exclusively of triplets from Japan (n = 1,305) and the Netherlands (n = 947). In both samples, left-handers had significantly lower birthweight (Japanese mean = 1,599 g [95% confidence interval (CI): 1,526-1,672 g]; Dutch mean = 1,794 g [95% CI: 1,709-1,879 g]) compared with right-handers (Japanese mean = 1,727 g [95% CI: 1,699-1,755 g]; Dutch mean = 1,903 g [95% CI: 1,867-1,938 g]). Within-family and between-family analyses both suggested that left-handedness is associated with lower birthweight, also when fully controlling for gestational age. Left-handers also had significantly delayed motor development and smaller infant head circumference compared with right-handers, but these associations diluted and became nonsignificant when controlling for birthweight. Our study in triplets provides evidence for the link between low birthweight and left-handedness. Our results also suggest that developmental differences between left-and right-handers are due to a shared etiology associated with low birthweight. LA - English DB - MTMT ER - TY - JOUR AU - O'Regan, Louise AU - Serrien, Deborah J. TI - Individual Differences and Hemispheric Asymmetries for Language and Spatial Attention JF - FRONTIERS IN HUMAN NEUROSCIENCE J2 - FRONT HUM NEUROSCI VL - 12 PY - 2018 PG - 13 SN - 1662-5161 DO - 10.3389/fnhum.2018.00380 UR - https://m2.mtmt.hu/api/publication/30324881 ID - 30324881 N1 - Funding Agency and Grant Number: BIAL foundation [376/14]\n Funding text: The work was supported by a research grant from the BIAL foundation to DS (Grant No. 376/14).\n \n Export Date: 26 November 2018 \n Correspondence Address: Serrien, D.J.; School of Psychology, University of NottinghamUnited Kingdom; email: deborah.serrien@nottingham.ac.uk Funding Agency and Grant Number: BIAL foundationBial Foundation [376/14] Funding text: The work was supported by a research grant from the BIAL foundation to DS (Grant No. 376/14). Cited By :17 Export Date: 9 September 2021 Correspondence Address: Serrien, D.J.; School of Psychology, United Kingdom; email: deborah.serrien@nottingham.ac.uk AB - Language and spatial processing are cognitive functions that are asymmetrically distributed across both cerebral hemispheres. In the present study, we compare left- and right-handers on word comprehension using a divided visual field paradigm and spatial attention using a landmark task. We investigate hemispheric asymmetries by assessing the participants' behavioral metrics; response accuracy, reaction time and their laterality index. The data showed that right-handers benefitted more from left- hemispheric lateralization for language comprehension and right-hemispheric lateralization for spatial attention than left-handers. Furthermore, left-handers demonstrated a more variable distribution across both hemispheres, supporting a less focal profile of functional brain organization. Taken together, the results underline that handedness distinctively modulates hemispheric processing and behavioral performance during verbal and nonverbal tasks. In particular, typical lateralization is most prevalent for right-handers whereas atypical lateralization is more evident for left-handers. These insights contribute to the understanding of individual variation of brain asymmetries and the mechanisms related to changes in cerebral dominance. LA - English DB - MTMT ER - TY - JOUR AU - Bradshaw, AR AU - Bishop, DVM AU - Woodhead, ZVJ TI - Methodological considerations in assessment of language lateralisation with fMRI: A systematic review JF - PEERJ J2 - PEERJ VL - 2017 PY - 2017 IS - 7 SN - 2167-8359 DO - 10.7717/peerj.3557 UR - https://m2.mtmt.hu/api/publication/26760233 ID - 26760233 N1 - Funding Agency and Grant Number: European Research CouncilEuropean Research Council (ERC)European Commission [694189]; WellcomeTrustWellcome TrustEuropean Commission [082498/Z/07/Z] Funding text: This work was supported by an Advanced Grant awarded by the European Research Council (project 694189-Cerebral Asymmetry: New directions in Correlates and Etiology - CANDICE). Dorothy Bishopis funded by a programme grant 082498/Z/07/Z from the WellcomeTrust. There was no additiona lexternal funding received for this project. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Cited By :30 Export Date: 9 September 2021 Correspondence Address: Bradshaw, A.R.; Department of Experimental Psychology, United Kingdom; email: abigail.bradshaw@psy.ox.ac.uk LA - English DB - MTMT ER - TY - JOUR AU - Piervincenzi, Claudia AU - Ben-Soussan, Tal D AU - Mauro, Federica AU - Mallio, Carlo A AU - Errante, Yuri AU - Quattrocchi, Carlo C AU - Carducci, Filippo TI - White Matter Microstructural Changes Following Quadrato Motor Training: A Longitudinal Study JF - FRONTIERS IN HUMAN NEUROSCIENCE J2 - FRONT HUM NEUROSCI VL - 11 PY - 2017 PG - 16 SN - 1662-5161 DO - 10.3389/fnhum.2017.00590 UR - https://m2.mtmt.hu/api/publication/27033878 ID - 27033878 N1 - Neuroimaging Laboratory, Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy Research Institute for Neuroscience Education and Didactics, Patrizio Paoletti Foundation, Assisi, Italy Departmental Faculty of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy Cited By :16 Export Date: 9 September 2021 Correspondence Address: Piervincenzi, C.; Neuroimaging Laboratory, Italy; email: claudia.piervincenzi@uniroma1.it LA - English DB - MTMT ER - TY - JOUR AU - Allendorfer, Jane B AU - Hernando, Kathleen A AU - Hossain, Shyla AU - Nenert, Rodolphe AU - Holland, Scott K AU - Szaflarski, Jerzy P TI - Arcuate Fasciculus Asymmetry Has a Hand in Language Function but not Handedness JF - HUMAN BRAIN MAPPING J2 - HUM BRAIN MAPP VL - 37 PY - 2016 IS - 9 SP - 3297 EP - 3309 PG - 13 SN - 1065-9471 DO - 10.1002/hbm.23241 UR - https://m2.mtmt.hu/api/publication/26251315 ID - 26251315 N1 - Funding Agency and Grant Number: NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01-NS048281]; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS048281] Funding Source: NIH RePORTER Funding text: Contract grant sponsor: NIH; Contract grant number: R01-NS048281 Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States Department of Neurology, University of Cincinnati Academic Health Center, Cincinnati, OH, United States Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States Cited By :24 Export Date: 9 September 2021 CODEN: HBMAE Correspondence Address: Allendorfer, J.B.; Department of Neurology, United States; email: jallendorfer@uabmc.edu LA - English DB - MTMT ER - TY - JOUR AU - Takaya, Shigetoshi AU - Liu, Hesheng AU - Greve, Douglas N AU - Tanaka, Naoaki AU - Leveroni, Catherine AU - Cole, Andrew J AU - Stufflebeam, Steven M TI - Altered anterior-posterior connectivity through the arcuate fasciculus in temporal lobe epilepsy JF - HUMAN BRAIN MAPPING J2 - HUM BRAIN MAPP VL - 37 PY - 2016 IS - 12 SP - 4425 EP - 4438 PG - 14 SN - 1065-9471 DO - 10.1002/hbm.23319 UR - https://m2.mtmt.hu/api/publication/27279101 ID - 27279101 N1 - Funding Agency and Grant Number: National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01-NS069696, P41-EB015896, U01-MH093765, T32-EB001680]; National Science FoundationNational Science Foundation (NSF) [NFSDMS-1042134]; Uehara Memorial FoundationUehara Memorial Foundation; SNMMI (Wagner-Torizuka Fellowship); Department of EnergyUnited States Department of Energy (DOE) [DE-SC0008430]; Grants-in-Aid for Scientific ResearchMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [16K09715] Funding Source: KAKEN; NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) [P41EB015896, T32EB001680] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF MENTAL HEALTHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [U01MH093765] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS069696, R01NS091604] Funding Source: NIH RePORTER Funding text: Contract grant sponsor: National Institute of Health; Contract grant numbers: R01-NS069696, P41-EB015896, U01-MH093765, T32-EB001680; Contract grant sponsor: National Science Foundation grant; Contract grant number: NFSDMS-1042134; Contract grant sponsors: Uehara Memorial Foundation, the SNMMI (Wagner-Torizuka Fellowship); Contract grant sponsor: Department of Energy; Contract grant number: DE-SC0008430 MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States Harvard Medical School, Boston, MA, United States Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States Department of Neurology, Massachusetts General Hospital, Boston, MA, United States Shigetoshi Takaya is currently at Human Brain Research Center, Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan Cited By :8 Export Date: 9 September 2021 CODEN: HBMAE Correspondence Address: Takaya, S.; Shigetoshi Takaya is currently at Human Brain Research Center, Japan; email: shig.t@kuhp.kyoto-u.ac.jp LA - English DB - MTMT ER - TY - JOUR AU - Tussis, L AU - Sollmann, N AU - Boeckh-Behrens, T AU - Meyer, B AU - Krieg, SM TI - Language function distribution in left-handers: A navigated transcranial magnetic stimulation study JF - NEUROPSYCHOLOGIA J2 - NEUROPSYCHOLOGIA VL - 82 PY - 2016 SP - 65 EP - 73 PG - 9 SN - 0028-3932 DO - 10.1016/j.neuropsychologia.2016.01.010 UR - https://m2.mtmt.hu/api/publication/25375992 ID - 25375992 N1 - Funding Agency and Grant Number: TUM Graduate School's Faculty Graduate Center of Medicine at the Technische Universitat Munchen Funding text: The first authors gratefully acknowledge the support of the TUM Graduate School's Faculty Graduate Center of Medicine at the Technische Universitat Munchen. Department of Neurosurgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, Munich, 81675, Germany TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, Munich, 81675, Germany Section of Neuroradiology, Department of Radiology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, Munich, 81675, Germany Cited By :4 Export Date: 9 September 2021 CODEN: NUPSA Correspondence Address: Krieg, S.M.; Department of Neurosurgery, Ismaninger Str. 22, Germany; email: Sandro.Krieg@tum.de LA - English DB - MTMT ER - TY - JOUR AU - Koeda, Michihiko AU - Watanabe, Atsushi AU - Tsuda, Kumiko AU - Matsumoto, Miwako AU - Ikeda, Yumiko AU - Kim, Woochan AU - Tateno, Amane AU - Naing, Banyar Than AU - Karibe, Hiroyuki AU - Shimada, Takashi AU - Suzuki, Hidenori AU - Matsuura, Masato AU - Okubo, Yoshiro TI - Interaction effect between handedness and CNTNAP2 polymorphism (rs7794745 genotype) on voice-specific frontotemporal activity in healthy individuals: an fMRI study JF - FRONTIERS IN BEHAVIORAL NEUROSCIENCE J2 - FRONT BEHAV NEUROSCI VL - 9 PY - 2015 PG - 13 SN - 1662-5153 DO - 10.3389/fnbeh.2015.00087 UR - https://m2.mtmt.hu/api/publication/32186805 ID - 32186805 N1 - Funding Agency and Grant Number: Health and Labor Sciences Research Grant for Research on Psychiatric and Neurological Diseases and Mental Health from Japanese Ministry of Health, Labor and Welfare [H23-seishin-ippan-002]; Grants-in-Aid for Scientific ResearchMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [15K20163, 15K09844] Funding Source: KAKEN Funding text: We gratefully acknowledge the staff of Yaesu Clinic, Nippon Medical School Hospital; Section of Biofunctional Informatics, Tokyo Medical and Dental University; and Voice Neurocognition Laboratory, University of Glasgow. This work was supported by a Health and Labor Sciences Research Grant for Research on Psychiatric and Neurological Diseases and Mental Health (H23-seishin-ippan-002) from the Japanese Ministry of Health, Labor and Welfare. AB - Recent neuroimaging studies have demonstrated that Contactin-associated protein-like2 (CNTNAP2) polymorphisms affect left-hemispheric function of language processing in healthy individuals, but no study has investigated the influence of these polymorphisms on right-hemispheric function involved in human voice perception. Further, although recent reports suggest that determination of handedness is influenced by genetic effect, the interaction effect between handedness and CNTNAP2 polymorphisms for brain activity in human voice perception and language processing has not been revealed. We aimed to investigate the interaction effect of handedness and CNTNAP2 polymorphisms in respect to brain function for human voice perception and language processing in healthy individuals. Brain function of 108 healthy volunteers (74 right-handed and 34 non-right-handed) was examined while they were passively listening to reverse sentences (rSEN), identifiable non-vocal sounds (SND), and sentences (SEN). Full factorial design analysis was calculated by using three factors: (1) rs7794745 (A/A or A/T), (2) rs2710102 [G/G or A carrier (A/G and A/A)], and (3) voice-specific response (rSEN or SND). The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG). This result suggests that rs7794745 genotype affects voice-specific brain function. Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness. These results suggest that CNTNAP2 polymorphisms could be one of the important factors in the neural development related to vocal communication and language processing in both right-handed and non-right-handed healthy individuals. LA - English DB - MTMT ER - TY - JOUR AU - Versace, Elisabetta AU - Vallortigara, Giorgio TI - Forelimb preferences in human beings and other species: multiple models for testing hypotheses on lateralization JF - FRONTIERS IN PSYCHOLOGY J2 - FRONT PSYCHOL VL - 6 PY - 2015 PG - 9 SN - 1664-1078 DO - 10.3389/fpsyg.2015.00233 UR - https://m2.mtmt.hu/api/publication/24664073 ID - 24664073 N1 - Cited By :81 Export Date: 9 September 2021 Correspondence Address: Versace, E.; Animal Cognition and Neuroscience Laboratory, Piazza della Manifattura 1, Italy; email: elisabetta.versace@unitn.it LA - English DB - MTMT ER - TY - JOUR AU - Xue, Fei AU - Fang, Guangzhan AU - Yang, Ping AU - Zhao, Ermi AU - Brauth, Steven E AU - Tang, Yezhong TI - The biological significance of acoustic stimuli determines ear preference in the music frog JF - JOURNAL OF EXPERIMENTAL BIOLOGY J2 - J EXP BIOL VL - 218 PY - 2015 IS - 5 SP - 740 EP - 747 PG - 8 SN - 0022-0949 DO - 10.1242/jeb.114694 UR - https://m2.mtmt.hu/api/publication/24664072 ID - 24664072 N1 - Funding Agency and Grant Number: National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31372217] Funding text: This work was supported by the grant from the National Natural Science Foundation of China (no. 31372217) to G.F. Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Sichuan University, Chengdu, Sichuan, 610064, China Department of Herpetology, Chengdu Institute of Biology, Chinese Academy of Sciences, Renmin South Road, Chengdu, Sichuan, 610041, China Department of Psychology, University of Maryland, College Park, MD 20742, United States Cited By :18 Export Date: 9 September 2021 CODEN: JEBIA Correspondence Address: Fang, G.; Department of Herpetology, Renmin South Road, China; email: fanggz@cib.ac.cn LA - English DB - MTMT ER - TY - GEN AU - Bailey, Janelle Lee TI - Language Pathways Defined in a Patient with Left Temporal Lobe DamageSecondary to Traumatic Brain Injury: A QEEG & MRI Study PY - 2014 SP - 1 EP - 68 UR - https://m2.mtmt.hu/api/publication/25415488 ID - 25415488 N1 - [Brigham Young University] LA - English DB - MTMT ER - TY - JOUR AU - Becker, N AU - Müller, JL AU - Rodrigues, JC AU - Villavicencio, A AU - De Salles, JF TI - ESTRATÉGIAS DE EVOCAÇÃO LEXICAL COM CRITÉRIO SEMÂNTICO EM ADULTOS APÓS ACIDENTE VASCULAR CEREBRAL NO HEMISFÉRIO DIREITO. SEMANTIC VERBAL FLUENCY STRATEGIES IN PATIENTS AFTER A RIGHT - HEMISPHERE STROKE TS - SEMANTIC VERBAL FLUENCY STRATEGIES IN PATIENTS AFTER A RIGHT - HEMISPHERE STROKE JF - LETRONICA: REVISTA DIGITAL DO PPGL J2 - LETRONICA VL - 7 PY - 2014 IS - 1 SP - 325 EP - 347 PG - 23 SN - 1984-4301 UR - https://m2.mtmt.hu/api/publication/24132345 ID - 24132345 LA - Portuguese DB - MTMT ER - TY - JOUR AU - Carey, David P AU - Johnstone, Leah T TI - Quantifying cerebral asymmetries for language in dextrals and adextrals with random-effects meta analysis JF - FRONTIERS IN PSYCHOLOGY J2 - FRONT PSYCHOL VL - 5 PY - 2014 PG - 23 SN - 1664-1078 DO - 10.3389/fpsyg.2014.01128 UR - https://m2.mtmt.hu/api/publication/26270831 ID - 26270831 N1 - Cited By :44 Export Date: 9 September 2021 Correspondence Address: Carey, D.P.; Perception, Brigantia Building, College Road, United Kingdom; email: d.carey@bangor.ac.uk LA - English DB - MTMT ER - TY - GEN AU - LEGER, CHARLES S TI - The Effect of Professional Ballet Training on Brain Structure: A Tale of Two Fractional Anisotropy Metrics PY - 2014 SP - 1 EP - 72 UR - https://m2.mtmt.hu/api/publication/25415486 ID - 25415486 N1 - [YORK UNIVERSITY TORONTO, ONTARIO] LA - English DB - MTMT ER - TY - JOUR AU - Ocklenburg, Sebastian AU - Beste, Christian AU - Arning, Larissa AU - Peterburs, Jutta AU - Guentuerkuen, Onur TI - The ontogenesis of language lateralization and its relation to handedness JF - NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS J2 - NEUROSCI BIOBEHAV R VL - 43 PY - 2014 SP - 191 EP - 198 PG - 8 SN - 0149-7634 DO - 10.1016/j.neubiorev.2014.04.008 UR - https://m2.mtmt.hu/api/publication/26270830 ID - 26270830 N1 - Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr-University Bochum, Germany Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Germany Department of Human Genetics, Ruhr-University, Bochum, Germany Department of Neurology, Division of Cognitive Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States Cited By :93 Export Date: 9 September 2021 CODEN: NBRED Correspondence Address: Ocklenburg, S.; Abteilung Biopsychologie, Institut für Kognitive Neurowissenschaft, Fakultät für Psychologie, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany; email: sebastian.ocklenburg@rub.de LA - English DB - MTMT ER - TY - CONF AU - Varga, Eszter AU - Schnell, Zsuzsanna AU - Perlaki, Gábor AU - Orsi, Gergely AU - Aradi, Mihály AU - Auer, T AU - John, F AU - Dóczi, Tamás Péter AU - Komoly, Sámuel AU - Kovács, Norbert AU - Schwarcz, Attila AU - Tényi, Tamás AU - Herold, Róbert AU - Janszky, József Vladimír AU - Horváth, Réka ED - Nick, Campbell ED - Dafydd, Gibbon ED - Daniel, Hirst TI - Hemispheric lateralization of sentence intonation in left handed subjects with typical and atypical language lateralization: An fMRI study T2 - 7th International Conference on Speech Prosody, SP 2014 PB - International Speech Communication Association (ISCA) C1 - Dublin T3 - Proceedings of the International Conference on Speech Prosody, ISSN 2333-2042 PY - 2014 SP - 1130 EP - 1133 PG - 4 UR - https://m2.mtmt.hu/api/publication/2715253 ID - 2715253 AB - Prosody (as the melody of speech) is an important component of human social interactions. More specifically, linguistic prosody conveys meaning of speech through syllable, word, or sentence level stress and intonation. In the modern neuroimaging era the hemispheric representation of sentence intonation is widely investigated. Most of these studies suggest bilateral activations predominantly in the perisylvian language areas and in the subdominant homologues. However, there are some inconsistencies about the hemispheric representation and lateralization of linguistic prosody. These inconsistencies could be due to the lack of attention on the language lateralization of the subjects. The present study aims to investigate the hemispheric representation and lateralization of linguistic prosody with a sentence intonation task in two groups of left handed subjects with typical and atypical language lateralization. Functional MRI was used to test the assumption that - according to the functional lateralization hypothesis - the representation of sentence intonation is predominantly lateralized within the language dominant hemisphere and the lateralization of sentence intonation is associated with language lateralization in both groups. Left handers were examined to create two groups of subjects with typical and atypical language lateralization. In all, 32 healthy subjects were evaluated with a standard verbal fluency task with fMRI in order to assess functional hemispheric language lateralization. In our final investigation the atypical group consisted of 8 subjects with right hemispheric language dominance (LI<-0.2) and the typical group also consisted of 8 subjects with left hemispheric language dominance (LI>0.2). Sentence intonation task was utilized to test linguistic prosody skills with fMRI. 49 pairs of sentences (18 pairs of neutral-neutral sentences, 10 pairs of interrogativeinterrogative sentences, and 1 pair of interrogative-neutral sentence) were presented with an event-related design. Sentences were matched in terms of syntactic structure, semantic complexity and length and all were affectively neutral. In the fMRI data analysis interrogative pairs were compared to neutral pairs. One of the main findings of our study is that subjects with typical language lateralization activated the middle temporal gyrus (MTG) on the right side. The activation of the MTG in the right hemisphere is classically associated with the encoding of prosodic information. Furthermore, both groups recruited the frontal and temporal language areas predominantly in the language-dominant hemisphere. Moreover, between-group comparison showed significantly stronger activations in subjects with typical language lateralization only in left sided language areas: pars triangularis of the inferior frontal gyrus, the superior frontal gyrus and the inferior parietal lobule. This finding is in accordance with the functional lateralization hypothesis of prosody, and suggests a correlation between linguistic prosody lateralization and language lateralization. LA - English DB - MTMT ER -