TY  - CHAP
AU  - Érdi, Péter
AU  - Matsuzawa, T
AU  - John, T
AU  - Kiss, Tamás
AU  - Zalányi, László András
ED  - Érdi, Péter
ED  - Sen, Bhattacharya B
ED  - Cochran, AL
TI  - Connecting Epilepsy and Alzheimer’s Disease: Modeling of Normal and Pathological Rhythmicity and Synaptic Plasticity Related to Amyloidββ (Aββ) Effects
T2  - Computational Neurology and Psychiatry
PB  - Springer Netherlands
CY  - Cham
SN  - 9783319499598
PY  - 2017
SP  - 93
EP  - 120
PG  - 28
DO  - 10.1007/978-3-319-49959-8_5
UR  - https://m2.mtmt.hu/api/publication/3248732
ID  - 3248732
AB  - This chapter is motivated by the hidden links between neurodegeneration due to Alzheimer’s disease and temporal lobe epileptic activity. The following argument is based on the multiple effects of $$\beta $$ -amyloid peptides (A $$\beta $$ ) forming these links potentially at molecular, cellular, synaptic, network, as well as system levels. To explore these links a computational framework was discussed, and two parts of the framework, i.e. pathological rhythm generation and altered bidirectional synaptic plasticity have been constructed and analyzed. By using a skeleton network model of the hippocampal rhythm generation it was demonstrated how A $$\beta $$ affects the ability of neurons in hippocampal networks to fire in unison at theta frequency resulting in reduced power of the theta rhythm. The dual qualitative effects of elevated A $$\beta $$ at the synaptic level, i.e. LTD facilitation and LTP impairment is studied by a modified calcium control hypothesis. The modification implemented the $$\beta $$ -amyloid effects on the bidirectional synaptic plasticity and explained well the experimental findings of decreased LTP and increased LTD. The analysis of a kinetic model taking into account the phosphorylation and dephosphorylation pathways associated with potentiation and depression of the AMPA receptor activity supported the biological plausibility of the modification. Such kinds of models offer an integrative perspective to organize scattered data obtained by methods of anatomy, electrophysiology, brain imaging, neurochemistry, behavioral studies, etc. into a coherent picture.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Matsuzawa, T
AU  - Zalányi, László András
AU  - Kiss, Tamás
AU  - Érdi, Péter
TI  - Multi-scale modeling of altered synaptic plasticity related to Amyloid effects
JF  - NEURAL NETWORKS
J2  - NEURAL NETWORKS
VL  - 93
PY  - 2017
SP  - 230
EP  - 239
PG  - 10
SN  - 0893-6080
DO  - 10.1016/j.neunet.2017.06.002
UR  - https://m2.mtmt.hu/api/publication/3243817
ID  - 3243817
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Érdi, Péter
AU  - John, T
AU  - Kiss, Tamás
AU  - Lever, CP
ED  - Bhattacharya, B
ED  - Chowdhury, F
TI  - Discovery and validation of biomarkers based on computational models of normal and pathological hippocampal rhythms
T2  - Validating Neuro-Computational Models of Neurological and Psychiatric Disorders
PB  - Springer Netherlands
CY  - New York, New York
SN  - 9781493919680
T3  - Springer Series in Computational Neuroscience, ISSN 2197-1900
PY  - 2015
SP  - 15
EP  - 42
PG  - 28
DO  - 10.1007/978-3-319-20037-8_2
UR  - https://m2.mtmt.hu/api/publication/2787957
ID  - 2787957
LA  - English
DB  - MTMT
ER  -