TY - JOUR AU - Tahara, M AU - Kubota, R AU - Nakazawa, H AU - Tokunaga, H AU - Nishimura, T TI - the behaviour and cholinesterase inhibitory activity of fenthion and its products by light and chlorination JF - JOURNAL OF WATER SUPPLY RESEARCH AND TECHNOLOGY-AQUA J2 - J WATER SUPPLY RES T VL - 57 PY - 2008 IS - 3 SP - 143 EP - 151 PG - 9 SN - 1606-9935 DO - 10.2166/aqua.2008.031 UR - https://m2.mtmt.hu/api/publication/23083893 ID - 23083893 LA - English DB - MTMT ER - TY - JOUR AU - Lengyel, Z AU - Szabó, Andrea AU - Papp, András AU - Nagymajtényi, László TI - Functional neurotoxic effects in rats acutely exposed to insecticide combinations JF - PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY J2 - PESTIC BIOCHEM PHYS VL - 87 PY - 2007 IS - 1 SP - 94 EP - 102 PG - 9 SN - 0048-3575 DO - 10.1016/j.pestbp.2006.06.005 UR - https://m2.mtmt.hu/api/publication/1240518 ID - 1240518 AB - The aim of the present study was to analyse the alterations in the cortical and peripheral electrophysiological activity of rats acutely treated with combinations of insecticides. Young adult male Wistar rats were treated with 1/5 and 1/25 LD50 of the insecticides dimethoate, propoxur, cypermethrin and amitraz, given alone or in triple or quadruple combinations. After 24 h, spontaneous cortical activity, and stimulus-evoked cortical and peripheral responses, was recorded and analysed. All treatments changed the cortical activity spectrum. The effect of the 1/5 LD50 combinations indicated non-additive interactions. In the cortical-evoked responses, dimethoate and its combinations gave the strongest change in the latency, while amitraz and its combinations, in the response duration. In the tail nerve, relative refractory period was the most sensitive parameter. The frequency dependence of the cortical responses was the most strongly altered by propoxur, and the least, by amitraz. Our results indicate that simultaneous exposure by various pesticide agents, which happens possibly also in humans, deserves further investigation in, among others, neurotoxicological points of view. Š 2006 Elsevier Inc. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Moser, VC TI - Animal models of chronic pesticide neurotoxicity JF - HUMAN & EXPERIMENTAL TOXICOLOGY J2 - HUM EXP TOXICOL VL - 26 PY - 2007 IS - 4 SP - 321 EP - 331 PG - 11 SN - 0960-3271 DO - 10.1177/0960327106072395 UR - https://m2.mtmt.hu/api/publication/22657767 ID - 22657767 N1 - Megjegyzés-23083761 10th Meeting of the International-Neurotoxicology-Association, Haikko, Finland LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Andrea AU - Papp, András AU - Nagymajtényi, László TI - Stimulus frequency dependence of the central and peripheral somatosensory evoked activity in rats treated with various pesticides JF - ACTA BIOLOGICA HUNGARICA (1983-2018) J2 - ACTA BIOL HUNG VL - 56 PY - 2005 IS - 3-4 SP - 205 EP - 214 PG - 10 SN - 0236-5383 DO - 10.1556/ABiol.56.2005.3-4.4 UR - https://m2.mtmt.hu/api/publication/1240509 ID - 1240509 AB - Rats were treated with a combination of insecticide agents in different timing schemes. In acute administration, 1/5 LD50 of the three insecticides: dimethoate, propoxur and cypermethrin, or their combination, was given once by gavage. In the developmental model, female rats received oral doses of 1/25 LD50 of the above insecticides in combination in three timing schemes including pregnancy and lactation. Responses in the somatosensory cortex and in the tail nerve, evoked by peripheral electric stimulation, were recorded in acute preparation under urethane anesthesia. It was tested whether the parameters of the cortical and peripheral evoked response are dependent on the frequency and whether this dependence is different in control and treated animals. The latency increase of the cortical responses with increasing stimulation frequency was significantly stronger in rats treated acutely with cypermethrin and the combination, and in rats receiving the combination during both intra- and extrauterine development. On the duration, the effects were less clear. Frequency dependent increase of the tail nerve action potential latency was significantly intensified by cypermethrin, and the amplitude decrease, by cypermethrin and dimethoate. Fatigue of this response during a stimulation series was also altered by the insecticides. Frequency dependence and fatigue possibly reflect the actual state of the nervous system and may have the potency to be developed to functional biomarkers. Š 2005 AkadĂŠmiai KiadĂł. LA - English DB - MTMT ER - TY - JOUR AU - Institóris, László AU - Papp, András AU - Siroki, O AU - Banerjee, B D TI - Comparative investigation of Behavioral, Neurotoxicological and Immuntoxicological Indices in Detection of Subacute Combined Exposure with methyl parathion and Propoxur in Rats JF - ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY J2 - ECOTOX ENVIRON SAFE VL - 57 PY - 2004 IS - 3 SP - 270 EP - 277 PG - 8 SN - 0147-6513 DO - 10.1016/S0147-6513(03)00101-5 UR - https://m2.mtmt.hu/api/publication/1308195 ID - 1308195 LA - English DB - MTMT ER - TY - JOUR AU - Clark, JM AU - Bing-Canar, J AU - Renninger, S AU - Dollpopf, R AU - El-Zein, J AU - Star, D AU - Zimmerman, D AU - Anisuzzaman, A AU - Boylan, K AU - Tomaszewski, T AU - Pearce, K AU - Yacovac, R AU - Erlwein, B AU - Ward, J TI - Methyl parathion in residential properties: Relocation and decontamination methodology JF - ENVIRONMENTAL HEALTH PERSPECTIVES J2 - ENVIRON HEALTH PERSP VL - 110 PY - 2002 SP - 1061 EP - 1070 PG - 10 SN - 0091-6765 UR - https://m2.mtmt.hu/api/publication/23194988 ID - 23194988 N1 - Megjegyzés-23088549 WOS:000180932100027 LA - English DB - MTMT ER - TY - JOUR AU - Carpentier, P AU - Foquin, A AU - Dorandeu, F AU - Lallement, G TI - Delta activity as an early indicator for soman-induced brain damage: A review JF - NEUROTOXICOLOGY J2 - NEUROTOXICOLOGY VL - 22 PY - 2001 IS - 3 SP - 299 EP - 315 PG - 17 SN - 0161-813X DO - 10.1016/A0161-813X(01)00019-5 UR - https://m2.mtmt.hu/api/publication/23088590 ID - 23088590 LA - English DB - MTMT ER - TY - JOUR AU - Institóris, László AU - Siroki, O AU - Undeger, U AU - Basaran, N AU - Dési, Illés TI - Immunotoxicological investigations on rats treated subacutely with dimethoate, As3+ and Hg2+ in combination JF - HUMAN & EXPERIMENTAL TOXICOLOGY J2 - HUM EXP TOXICOL VL - 20 PY - 2001 IS - 7 SP - 329 EP - 336 PG - 8 SN - 0960-3271 DO - 10.1191/096032701680350569 UR - https://m2.mtmt.hu/api/publication/2139143 ID - 2139143 AB - Effects of combined exposure with dimethoate (DM), HgCl2 (Hg), and NaAsO2 (As) were investigated following a 28 - day oral exposure in male Wistar rats. In preliminary experiments, the LOEL (Lowest Observed Effect Level) and NOEL (Non Observed Effect Level) doses of the substances were determined using the same experimental system [determination of body weight gain, organ weights of brain, thymus, heart, lung, kidneys, adrenals, spleen, testicles, popliteal lymph node, white blood cell (WBC) and red blood cell (RBC) count, haematocrit (Ht), mean cell volume (MCV) of RBCs, cell content of the femoral bone marrow, IgM-plaque forming cell (PFC) content of the spleen, delayed type hypersensitivity (DTH) reaction] and animal strain. In the combination studies, LOEL dose of DM (28.2 mg/kg) was combined with NOEL doses of the heavy metals ( HgCl2 = 0.40 mg/kg, NaAsO2 = 3.33 mg/kg), and vice versa (DM = 7.04 mg/kg, HgCl2 = 3.20 mg/kg, NaAsO2 = 13.3 mg/kg). In the DM-Hg combinations, significant alterations were found versus the corresponding high- dose internal control in the body weight gain, relative liver and kidney weights, and in the PFC response. When DM was combined with As, interactions were indicated by changes of relative liver weight, MCV value, and the PFC content of the spleen. These results support the theory that the interactions between pesticides and heavy metals may modify the toxic effects of the single substances, and may also change the functional detection limits of the exposure. The changes in the functional detection limits, if they occur, can lead to false-positive and false-negative results in human epidemiological studies. LA - English DB - MTMT ER - TY - JOUR AU - Zhu, H AU - Rockhold, RW AU - Baker, RC AU - Kramer, RE AU - Ho, IK TI - Effects of single or repeated dermal exposure to methyl parathion on behavior and blood cholinesterase activity in rats JF - JOURNAL OF BIOMEDICAL SCIENCE J2 - J BIOMED SCI VL - 8 PY - 2001 IS - 6 SP - 467 EP - 474 PG - 8 SN - 1021-7770 UR - https://m2.mtmt.hu/api/publication/23083879 ID - 23083879 LA - English DB - MTMT ER - TY - JOUR AU - Undeger, U AU - Institóris, László AU - Siroki, O AU - Nehez, M AU - Dési, Illés TI - Simultaneous geno- and immunotoxicological investigations for early detection of organophosphate toxicity in rats. JF - ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY J2 - ECOTOX ENVIRON SAFE VL - 45 PY - 2000 IS - 1 SP - 43 EP - 48 PG - 6 SN - 0147-6513 DO - 10.1006/eesa.1999.1844 UR - https://m2.mtmt.hu/api/publication/2139146 ID - 2139146 AB - Detectability of toxic effects by repeated doses of dimethoate (DM) and methylparathion (MPT) were investigated by geno-and immunotoxicological methods in male Wistar rats following a 28-day oral exposure. In the dose range of 28.2, 14.1, and 7.04, and 7.04 mg/kg/day DM, the two higher doses decreased the body weight gain. The top dose increased the weight of liver, kidneys, and testicles; the white blood cell count; and the cell content of the femoral bone marrow. From immune function parameters measured [IgM-plaque forming cells (PFC) assay, delayed-type hypersensitivity (DTH) reaction] only the maximum of the DTH reaction decreased at the top dose. Of the MPT doses (0.872, 0.436, and 0.218 mg/kg/day) the two higher ones increased the liver weight, and a dose-dependent increase was found in the MCV value. No evaluable changes in the examined immune function parameters were observed. Both substances increased the number of numerical but not the structural chromosome aberrations at lower dose levels (the two larger doses of DM, and all the three doses of MPT) than those ones which caused changes in the examined immune function parameters. According to these results, the genotoxicological approach seems to be more sensitive for detection of repeated-dose oral toxicity of the investigated two organophosphates than the immunotoxicological one. LA - English DB - MTMT ER - TY - JOUR AU - Dési, Illés AU - Nagymajtényi, László TI - Electrophysiological biomarkers of an organophosphorous pesticide, dichlorvos. JF - TOXICOLOGY LETTERS J2 - TOXICOL LETT VL - 107 PY - 1999 IS - 1-3 SP - 55 EP - 64 PG - 10 SN - 0378-4274 DO - 10.1016/S0378-4274(99)00031-4 UR - https://m2.mtmt.hu/api/publication/2110977 ID - 2110977 LA - English DB - MTMT ER - TY - JOUR AU - Lallement, G AU - Clarencon, D AU - Masqueliez, C AU - Baubichon, D AU - Galonnier, M AU - Burchkhart, M-F AU - Peoc'h M, null AU - Mestries, JC TI - Nerve agent poisoning in primates: Antilethal, anti-epileptic and neuroprotective effects of GK-11 JF - ARCHIVES OF TOXICOLOGY J2 - ARCH TOXICOL VL - 72 PY - 1997 IS - 2 SP - 84 EP - 92 PG - 9 SN - 0340-5761 UR - https://m2.mtmt.hu/api/publication/23083883 ID - 23083883 LA - English DB - MTMT ER - TY - JOUR AU - Yilmazlar, A AU - Ozyurt, G TI - Brain involvement in organophosphate poisoning JF - ENVIRONMENTAL RESEARCH J2 - ENVIRON RES VL - 74 PY - 1997 IS - 2 SP - 104 EP - 109 PG - 6 SN - 0013-9351 DO - 10.1006/enrs.1997.3758 UR - https://m2.mtmt.hu/api/publication/23276904 ID - 23276904 LA - English DB - MTMT ER -