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However, little is known about its effects on the neurodevelopment of infants. Objectives To examine early-life exposure to Al in relation to neurodevelopment in healthy infants. Methods Nail Al concentrations were measured among 747 newborn babies within 6 months of delivery in the Shanghai Birth Cohort. Neurodevelopment was assessed using Ages and stages questionnaire (third edition, ASQ-3) at ages 6 and 12 months. General linear regression models were performed to estimate the associations between Al concentrations and ASQ-3 scores. Results After adjustment for potential confounders, early-life exposure to Al was not associated with any neurodevelopmental performance at age 6 months. However, Al level was associated with an increased risk of having a low fine motor score (quartile 4 vs. quartile 1, mean difference (MD): -1.63; 95% confidence interval (CI): -3.22, -0.05; P-trend < 0.01) at 12 months. No association was found for communication, gross motor, problem-solving, or personal-social score at 12 months. Significance Early-life exposure to Al may be associated with poor fine motor skills in a dose-response manner among apparently healthy infants at age 12 months.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12347, "link" : "/api/classification/12347", "label" : "Egészségtudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 10399, "link" : "/api/classification/10399", "label" : "Föld- és kapcsolódó környezettudományok", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 2927, "link" : "/api/keyword/2927", "label" : "ALUMINUM", "published" : true, "oldId" : 2927, "snippet" : true }, { "otype" : "Keyword", "mtid" : 19274, "link" : "/api/keyword/19274", "label" : "INFANTS", "published" : true, "oldId" : 19274, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1084282, "link" : "/api/keyword/1084282", "label" : "neurodevelopment", "published" : true, "oldId" : 1084282, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1732525, "link" : "/api/keyword/1732525", "label" : "fine motor skills", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2394824, "link" : "/api/keyword/2394824", "label" : "Early-life exposure", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2021, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2023-12-18", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "SjrRating", "mtid" : 11238366, "link" : "/api/sjrrating/11238366", "label" : "sjr:D1 (2021) Scopus - Toxicology JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY 1559-0631", "listPos" : 9, "rankValue" : 0.1, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 3005, "link" : "/api/classificationexternal/3005", "label" : "Scopus - Toxicology", "published" : true, "oldId" : 3005, "snippet" : true }, "ranking" : "D1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "D1", "hasCitationDuplums" : false, "userChangeableUntil" : "2023-09-22T18:53:09.268+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 1, "ownerInstituteCount" : 19, "directInstituteCount" : 0, "authorCount" : 10, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/32277360", "label" : "Ma Rui et al. 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