@article{MTMT:32277360, title = {Early-life exposure to aluminum and fine motor performance in infants: a longitudinal study}, url = {https://m2.mtmt.hu/api/publication/32277360}, author = {Ma, Rui and Yang, Kefeng and Chen, Cheng and Mao, Xuanxia and Shen, Xiuhua and Jiang, Linlei and Ouyang, Fengxiu and Tian, Ying and Zhang, Jun and Kahe, Ka}, doi = {10.1038/s41370-021-00294-9}, journal-iso = {J EXPO SCI ENV EPID}, journal = {JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY}, volume = {31}, unique-id = {32277360}, issn = {1559-0631}, abstract = {Background Aluminum (Al) is a well-established neurotoxicant. However, little is known about its effects on the neurodevelopment of infants. Objectives To examine early-life exposure to Al in relation to neurodevelopment in healthy infants. Methods Nail Al concentrations were measured among 747 newborn babies within 6 months of delivery in the Shanghai Birth Cohort. Neurodevelopment was assessed using Ages and stages questionnaire (third edition, ASQ-3) at ages 6 and 12 months. General linear regression models were performed to estimate the associations between Al concentrations and ASQ-3 scores. Results After adjustment for potential confounders, early-life exposure to Al was not associated with any neurodevelopmental performance at age 6 months. However, Al level was associated with an increased risk of having a low fine motor score (quartile 4 vs. quartile 1, mean difference (MD): -1.63; 95% confidence interval (CI): -3.22, -0.05; P-trend < 0.01) at 12 months. No association was found for communication, gross motor, problem-solving, or personal-social score at 12 months. Significance Early-life exposure to Al may be associated with poor fine motor skills in a dose-response manner among apparently healthy infants at age 12 months.}, keywords = {ALUMINUM; INFANTS; neurodevelopment; fine motor skills; Early-life exposure}, year = {2021}, eissn = {1559-064X}, pages = {248-256} } @article{MTMT:33814207, title = {Dissimilar Anxiety-like Behavior in Prepubertal and Young Adult Female Rats on Acute Exposure to Aluminium}, url = {https://m2.mtmt.hu/api/publication/33814207}, author = {Sengupta, T. and Ghosh, S. and Gaur, A. and Nayak, P.}, doi = {10.2174/1871524922666211231095507}, journal-iso = {CENT NERV SYST AGENTS MED CHEM}, journal = {CENTRAL NERVOUS SYSTEM AGENTS IN MEDICINAL CHEMISTRY}, volume = {21}, unique-id = {33814207}, issn = {1871-5249}, year = {2021}, eissn = {1875-6166}, pages = {187-194} } @article{MTMT:31471625, title = {In Utero Exposure to Aluminium and Other Neurotoxic Elements in Urban Coastal South African Women at Delivery: An Emerging Concern}, url = {https://m2.mtmt.hu/api/publication/31471625}, author = {Roellin, Halina B. and Channa, Kalavati and Olutola, Bukola and Nogueira, Claudina and Odland, Jon O.}, doi = {10.3390/ijerph17051724}, journal-iso = {INT J ENV RES PUB HE}, journal = {INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH}, volume = {17}, unique-id = {31471625}, issn = {1661-7827}, abstract = {Aluminium (Al) is a non-essential neurotoxicant and there is limited information regarding exposure to Al in utero. This study sought to evaluate the in utero exposure to Al in urban South African women, its effects on birth outcomes and possible synergistic effects between Al, essential and neurotoxic elements such as lead (Pb), mercury (Hg) and arsenic (As), as well as a a potential sex-dependent response to these elements in neonates. This study has found elevated levels of Al in urban women at delivery. The Spearman's rank correlation coefficients (p-value) of the association between maternal serum Al and birth outcomes (gestational age and parity), and between maternal serum Al and Cu, Zn and Se, were statistically significant. However, in the general and the stratified models, no association was found between any of the birth outcomes and maternal serum Al. The association between maternal serum Al and neurotoxic elements at delivery showed a significant positive correlation for Pb only (rho = 0.361; p < 0.001) which was found to be sex-dependent in neonates (males, rho = 0.285; p < 0.004 and females, rho = 0.444, p < 0.001). Our preliminary findings indicate that in utero exposure to Al is an emerging concern requiring further research and directives from public health authorities.}, keywords = {Aluminium; Birth outcomes; Essential trace elements; In utero exposure; neurotoxic elements; sex-dependent response to toxicants}, year = {2020}, eissn = {1660-4601} } @article{MTMT:31740096, title = {Aluminum reproductive toxicity: a summary and interpretation of scientific reports}, url = {https://m2.mtmt.hu/api/publication/31740096}, author = {Yokel, Robert A.}, doi = {10.1080/10408444.2020.1801575}, journal-iso = {CRIT REV TOXICOL}, journal = {CRITICAL REVIEWS IN TOXICOLOGY}, volume = {50}, unique-id = {31740096}, issn = {1040-8444}, abstract = {Publications addressing aluminum (Al)-induced reproductive toxicity were reviewed. Key details were compiled in summary tables. Approximate systemic Al exposure, a measure of bioavailability, was calculated for each exposure, based on the Al percentage in the dosed Al species, Al bioavailability, and absorption time course reports for the exposure route. This was limited to laboratory animal studies because no controlled-exposure human studies were found. Intended Al exposure was compared to unintended dietary Al exposure. The considerable and variable Al content of laboratory animal diets creates uncertainty about reproductive function in the absence of Al. Aluminum-induced reproductive toxicity in female mice and rats was evident after exposure to >= 25-fold the amount of Al consumed in the diet. Generally, the additional daily Al systemic exposure of studies that reported statistically significant results was greater than 100-fold above the typical human daily Al dietary consumption equivalent. Male reproductive endpoints were significantly affected after exposure to lower levels of Al than females. Increased Al intake increased fetus, placenta, and testes Al concentrations, to a greater extent in the placenta than fetus, and, in some cases, more in the testes than placenta. An adverse outcome pathway (AOP) was constructed for males based on the results of the reviewed studies. The proposed AOP includes oxidative stress as the molecular initiating event and increased malondialdehyde, DNA and spermatozoal damage, and decreased blood testosterone and sperm count as subsequent key events. Recommendations for the design of future studies of reproductive outcomes following exposure to Al are provided.}, keywords = {Female; Male; MICE; RATS; SPERMATOZOA; reproduction; ALUMINUM; testosterone; injection; fetus; placenta; testis; Adverse outcome pathways; Oxidative stress; oral intake}, year = {2020}, eissn = {1547-6898}, pages = {551-593} } @article{MTMT:30955398, title = {Curcumin prevents the midbrain dopaminergic innervations and locomotor performance deficiencies resulting from chronic aluminum exposure in rat}, url = {https://m2.mtmt.hu/api/publication/30955398}, author = {Laabbar, Wafaa and Elgot, Abdeljalil and Elhiba, Omar and Gamrani, Halima}, doi = {10.1016/j.jchemneu.2019.101654}, journal-iso = {J CHEM NEUROANAT}, journal = {JOURNAL OF CHEMICAL NEUROANATOMY}, volume = {100}, unique-id = {30955398}, issn = {0891-0618}, abstract = {Aluminum (Al) among the abundant metals on the earth crust, is able to cross the biological barriers via the gastrointestinal and lung tissues. Once in the body, this heavy metal accumulates in different organs, especially the central nervous system. Though its influence is evidently shown in the substantia nigra of Parkinson's disease patients and other brain areas in other neurodegenerative diseases, few studies have demonstrated that Al could trigger profound changes in neurotransmission systems including the dopaminergic (DAergic) system. A variety of medicinal plants may be prescribed in such contamination, including some culinary spices such as Curcumin (Cur). Several studies have proven Cur to exhibit a wide variety of biological and pharmacological activities, especially its antioxidant potential. Using the immunohistochemistry, of tyrosine hydroxylase (TH), in the midbrain substantia nigra pars compact (SNc) and the ventral tegmental area (VTA) and the open field test, we examined the DAergic system together with the locomotor behavior respectively in rats exposed chronically to Al (0,3%) in drinking water during 4 months since the intra-uterine age, as well as the neuroprotective effect of the concomitant administration of Cur I (30 mg/kg B.W) of chronic Al exposed rats. Our results have shown a significant decrease of TH immureactivity in both SNc and VTA associated to a loss of the number of crossed boxes, leading to a difficient locomotor performance in the Al group while Cur I prevents such TH immunoreactivity impairment and maintains a higher locomotor activity in the Al-Curl group. Our findings lead to suppose a powerful and obvious neuroprotective potential of Curl against Al-induced neurotoxicity of the DAergic system involved in the control of the locomotor behavior.}, keywords = {ALUMINUM; substantia nigra; Chronic intoxication; Parkinson's disease; Ventral tegmental area; CURCUMIN; Locomotor activity; TYROSINE HYDROXYLASE; WISTAR RATS}, year = {2019}, eissn = {1873-6300} } @article{MTMT:27161132, title = {Amelioration of aluminum- and fluoride-induced behavioral alterations through resveratrol in rats}, url = {https://m2.mtmt.hu/api/publication/27161132}, author = {Nallagouni, CSR and Mesram, N and Karnati, PR}, doi = {10.22159/ajpcr.2018.v11i1.21620}, journal-iso = {ASIA J PHARMACEU CLIN RES}, journal = {ASIAN JOURNAL OF PHARMACEUTICAL AND CLINICAL RESEARCH}, volume = {11}, unique-id = {27161132}, issn = {0974-2441}, year = {2018}, eissn = {2455-3891}, pages = {289-293} } @article{MTMT:27488209, title = {Prenatal exposure to aluminum and status of selected essential trace elements in rural South African women at delivery}, url = {https://m2.mtmt.hu/api/publication/27488209}, author = {Röllin, HB and Nogueira, C and Olutola, B and Channa, K and Odland, JØ}, doi = {10.3390/ijerph15071494}, journal-iso = {INT J ENV RES PUB HE}, journal = {INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH}, volume = {15}, unique-id = {27488209}, issn = {1661-7827}, year = {2018}, eissn = {1660-4601} } @article{MTMT:33814208, title = {Behavioral effects of long-term oral administration of aluminum ammonium sulfate in male and female C57BL/6J mice}, url = {https://m2.mtmt.hu/api/publication/33814208}, author = {Shoji, H. and Irino, Y. and Yoshida, M. and Miyakawa, T.}, doi = {10.1002/npr2.12002}, journal-iso = {NEUROPSYCHOPHARMACOL REP}, journal = {NEUROPSYCHOPHARMACOLOGY REPORTS}, volume = {38}, unique-id = {33814208}, year = {2018}, eissn = {2574-173X}, pages = {18-36} } @article{MTMT:24237454, title = {Assessment of genotoxicity of aluminium acetate in bone marrow, male germ cells and fetal liver cells of Swiss albino mice}, url = {https://m2.mtmt.hu/api/publication/24237454}, author = {D'Souza, SP and Vijayalaxmi, KK and Naik, P}, doi = {10.1016/j.mrgentox.2014.02.006}, journal-iso = {MUTAT RES-GEN TOX EN}, journal = {MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS}, volume = {766}, unique-id = {24237454}, issn = {1383-5718}, year = {2014}, eissn = {1879-3592}, pages = {16-22} } @article{MTMT:24237453, title = {Luminescent Fluorene-Based Bis-Pyrazolyl Aniline Ligand for Aluminum Detection}, url = {https://m2.mtmt.hu/api/publication/24237453}, author = {Frazer, A and Morales, AR and Woodward, AW and Tongwa, P and Timofeeva, T and Belfield, KD}, doi = {10.1007/s10895-013-1291-x}, journal-iso = {J FLUORESC}, journal = {JOURNAL OF FLUORESCENCE}, volume = {24}, unique-id = {24237453}, issn = {1053-0509}, year = {2014}, eissn = {1573-4994}, pages = {239-250} } @article{MTMT:23638462, title = {Accumulation, elimination, and effects of parenteral exposure to aluminum in newborn and adult rats}, url = {https://m2.mtmt.hu/api/publication/23638462}, author = {Veiga, M and Bohrer, D and Bandero, CRR and Oliveira, SMR and do, Nascimento PC and Mattiazzi, P and Mello, CF and Lenz, QF and Oliveira, MS}, doi = {10.1016/j.jinorgbio.2013.07.028}, journal-iso = {J INORG BIOCHEM}, journal = {JOURNAL OF INORGANIC BIOCHEMISTRY}, volume = {128}, unique-id = {23638462}, issn = {0162-0134}, year = {2013}, eissn = {1873-3344}, pages = {215-220} } @article{MTMT:22543812, title = {The impairment of one-trial passive avoidance learning in chicks caused by prenatal aluminum exposure}, url = {https://m2.mtmt.hu/api/publication/22543812}, author = {Xing, R and Zhong, ZM and Ma, HB and Cui, YH and Zheng, YW and Xu, SQ and Che, Y}, doi = {10.1002/dev.20589}, journal-iso = {DEV PSYCHOBIOL}, journal = {DEVELOPMENTAL PSYCHOBIOLOGY}, volume = {54}, unique-id = {22543812}, issn = {0012-1630}, year = {2012}, eissn = {1098-2302}, pages = {133-138} } @article{MTMT:23638463, title = {Aluminum overload increases oxidative stress in four functional brain areas of neonatal rats}, url = {https://m2.mtmt.hu/api/publication/23638463}, author = {Yuan, CY and Lee, YJ and Hsu, GSW}, doi = {10.1186/1423-0127-19-51}, journal-iso = {J BIOMED SCI}, journal = {JOURNAL OF BIOMEDICAL SCIENCE}, volume = {19}, unique-id = {23638463}, issn = {1021-7770}, year = {2012}, eissn = {1423-0127} } @{MTMT:26944367, title = {Aluminum}, url = {https://m2.mtmt.hu/api/publication/26944367}, author = {Domingo, JL}, booktitle = {Reproductive and Developmental Toxicology}, doi = {10.1016/B978-0-12-382032-7.10032-3}, publisher = {Elsevier Inc.}, unique-id = {26944367}, year = {2011}, pages = {407-413} } @article{MTMT:22278888, title = {Chronic exposure to aluminum reduces tyrosine hydroxylase expression in the substantia nigra and locomotor performance in rats}, url = {https://m2.mtmt.hu/api/publication/22278888}, author = {Erazi, H and Ahboucha, S and Gamrani, H}, doi = {10.1016/j.neulet.2010.09.053}, journal-iso = {NEUROSCI LETT}, journal = {NEUROSCIENCE LETTERS}, volume = {487}, unique-id = {22278888}, issn = {0304-3940}, year = {2011}, eissn = {1872-7972}, pages = {8-11} } @article{MTMT:22278889, title = {Aluminum Vaccine Adjuvants: Are they Safe?}, url = {https://m2.mtmt.hu/api/publication/22278889}, author = {Tomljenovic, L and Shaw, CA}, doi = {10.2174/092986711795933740}, journal-iso = {CURR MED CHEM}, journal = {CURRENT MEDICINAL CHEMISTRY}, volume = {18}, unique-id = {22278889}, issn = {0929-8673}, year = {2011}, eissn = {1875-533X}, pages = {2630-2637} } @article{MTMT:22278890, title = {Aluminum alters NMDA receptor 1A and 2A/B expression on neonatal hippocampal neurons in rats}, url = {https://m2.mtmt.hu/api/publication/22278890}, author = {Yuan, CY and Hsu, GSW and Lee, YJ}, doi = {10.1186/1423-0127-18-81}, journal-iso = {J BIOMED SCI}, journal = {JOURNAL OF BIOMEDICAL SCIENCE}, volume = {18}, unique-id = {22278890}, issn = {1021-7770}, year = {2011}, eissn = {1423-0127} } @article{MTMT:22278891, title = {Aluminum affects glial system and behavior of rats}, url = {https://m2.mtmt.hu/api/publication/22278891}, author = {Erazi, H and Sansar, W and Ahboucha, S and Gamrani, H}, doi = {10.1016/j.crvi.2009.09.016}, journal-iso = {CR BIOL}, journal = {COMPTES RENDUS BIOLOGIES}, volume = {333}, unique-id = {22278891}, issn = {1631-0691}, year = {2010}, eissn = {1768-3238}, pages = {23-27} } @article{MTMT:26944368, title = {Effect of oral aluminum chloride administration during lactation on short and long-term memory of their offspring}, url = {https://m2.mtmt.hu/api/publication/26944368}, author = {Ali, MA and Vostacolaee, E and Rahim, C}, doi = {10.3923/jbs.2008.767.772}, journal-iso = {JOURNAL OF BIOLOGICAL SCIENCES}, journal = {JOURNAL OF BIOLOGICAL SCIENCES}, volume = {8}, unique-id = {26944368}, issn = {1727-3048}, year = {2008}, eissn = {1812-5719}, pages = {767-772} } @article{MTMT:24681685, title = {Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide}, url = {https://m2.mtmt.hu/api/publication/24681685}, author = {Krewski, Daniel and Yokel, Robert A and Nieboer, Evert and Borchelt, David and Cohen, Joshua and Harry, Jean and Kacew, Sam and Lindsay, Joan and Mahfouz, Amal M and Rondeau, Virginie}, doi = {10.1080/10937400701597766}, journal-iso = {J TOXICOL ENV HEAL B}, journal = {JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS}, volume = {10}, unique-id = {24681685}, issn = {1093-7404}, year = {2007}, eissn = {1521-6950}, pages = {1-269} } @article{MTMT:22278894, title = {Influence of age on aluminum-induced neurobehavioral effects and morphological changes in rat brain}, url = {https://m2.mtmt.hu/api/publication/22278894}, author = {Colomina, MT and Roig, JL and Sanchez, DJ and Domingo, JL}, doi = {10.1016/S0161-813X(02)00008-6}, journal-iso = {NEUROTOXICOLOGY}, journal = {NEUROTOXICOLOGY}, volume = {23}, unique-id = {22278894}, issn = {0161-813X}, year = {2002}, eissn = {1872-9711}, pages = {775-781} } @article{MTMT:22278893, title = {No spatial working memory deficit in beta-amyloid-exposed rats - A longitudinal study}, url = {https://m2.mtmt.hu/api/publication/22278893}, author = {Roloff, EV and Platt, B and Riedel, G}, doi = {10.1016/S0278-5846(02)00211-7}, journal-iso = {PROG NEURO-PSYCHOPHARMACOL BIOL PSYCHIATR}, journal = {PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY}, volume = {26}, unique-id = {22278893}, issn = {0278-5846}, year = {2002}, eissn = {1878-4216}, pages = {955-970} } @article{MTMT:22278895, title = {Aluminium incorporation into the brain of rat fetuses and sucklings}, url = {https://m2.mtmt.hu/api/publication/22278895}, author = {Yumoto, S and Nagai, H and Matsuzaki, H and Matsumura, H and Tada, W and Nagatsuma, E and Kobayashi, K}, doi = {10.1016/S0361-9230(01)00509-3}, journal-iso = {BRAIN RES BULL}, journal = {BRAIN RESEARCH BULLETIN}, volume = {55}, unique-id = {22278895}, issn = {0361-9230}, year = {2001}, eissn = {1873-2747}, pages = {229-234} } @article{MTMT:22278896, title = {Transplacental passage of (26)Al from pregnant rats to fetuses and (26)Al transfer through maternal milk to suckling rats}, url = {https://m2.mtmt.hu/api/publication/22278896}, author = {Yumoto, S and Nagai, H and Matsuzaki, H and Kobayashi, T and Tada, W and Ohki, Y and Kakimi, S and Kobayashi, K}, doi = {10.1016/S0168-583X(00)00096-3}, journal-iso = {NUCL INSTRUM METH B}, journal = {NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS}, volume = {172}, unique-id = {22278896}, issn = {0168-583X}, year = {2000}, eissn = {1872-9584}, pages = {925-929} } @article{MTMT:22278897, title = {Exposure of pregnant mice to aluminum and restraint stress: Effects on postnatal development and behavior of the offspring}, url = {https://m2.mtmt.hu/api/publication/22278897}, author = {Colomina, MT and Sanchez, DJ and Domingo, JL and Sanchez-Turet, M}, journal-iso = {PSYCHOBIOLOGY}, journal = {PSYCHOBIOLOGY}, volume = {27}, unique-id = {22278897}, issn = {0889-6313}, year = {1999}, eissn = {2197-9960}, pages = {521-529} } @article{MTMT:22278898, title = {A molecular mechanism of aluminium-induced Alzheimer's disease?}, url = {https://m2.mtmt.hu/api/publication/22278898}, author = {Exley, C}, doi = {10.1016/S0162-0134(99)00125-7}, journal-iso = {J INORG BIOCHEM}, journal = {JOURNAL OF INORGANIC BIOCHEMISTRY}, volume = {76}, unique-id = {22278898}, issn = {0162-0134}, year = {1999}, eissn = {1873-3344}, pages = {133-140} } @article{MTMT:22278899, title = {Developmental neurotoxicity and immunotoxicity of 2,4,6-tribromophenol in Wistar rats}, url = {https://m2.mtmt.hu/api/publication/22278899}, author = {Lyubimov, AV and Babin, VV and Kartashov, AI}, journal-iso = {NEUROTOXICOLOGY}, journal = {NEUROTOXICOLOGY}, volume = {19}, unique-id = {22278899}, issn = {0161-813X}, year = {1998}, eissn = {1872-9711}, pages = {303-312} } @article{MTMT:1946522, title = {The effect of social learning on a conditioned avoidance response of rats treated prenatally with aluminum lactate}, url = {https://m2.mtmt.hu/api/publication/1946522}, author = {Gonda, Z and Miklósi, Ádám and Lehotzky, K}, doi = {10.1016/S0892-0362(96)00133-X}, journal-iso = {NEUROTOXICOL TERATOL}, journal = {NEUROTOXICOLOGY AND TERATOLOGY}, volume = {19}, unique-id = {1946522}, issn = {0892-0362}, abstract = {Aluminum (Al) has been proven to be a behavioral teratogenic agent in a number of experimental studies. Prenatal exposures to Al lactate have been shown to cause cognitive deficits in a variety of species. The present experiment was carried out on SPRD rat pups treated prenatally with Al lactate to determine whether observational conditioning (social learning) would reverse the impairment in learning described previously following such treatment. A conditioned avoidance response was used as an observational learning task. The results provide evidence that Al-treated pups are capable of social learning (i.e., the performance of the avoidance response improved as a result of observational learning); however, the response latency of the avoidance response was not different in these animals from those that were not exposed to such facilitation, suggesting that additional factors are involved in the effects of prenatal aluminum intoxication on cognitive processes. (C) 1997 Elsevier Science Inc.}, keywords = {Neurotoxicity; MICE; exposure; ALUMINUM; TOXICITY; Rabbit; Prenatal; GESTATION; NEUROFIBRILLARY DEGENERATION; ENCEPHALOPATHY; DEVELOPMENTAL ALTERATIONS; observational conditioning; rat}, year = {1997}, eissn = {1872-9738}, pages = {59-63}, orcid-numbers = {Miklósi, Ádám/0000-0003-4831-8985} } @article{MTMT:24081144, title = {Effect of prenatal aluminium lactate exposure on conditioned taste aversion and passive avoidance task in the rat}, url = {https://m2.mtmt.hu/api/publication/24081144}, author = {Gonda, Z and Lehotzky, K}, doi = {10.1002/(SICI)1099-1263(199611)16:6<529::AID-JAT392>3.0.CO;2-S}, journal-iso = {J APPL TOXICOL}, journal = {JOURNAL OF APPLIED TOXICOLOGY}, volume = {16}, unique-id = {24081144}, issn = {0260-437X}, year = {1996}, eissn = {1099-1263}, pages = {529-532} }