TY  - JOUR
AU  - Chen, Lijuan
AU  - Zhang, Zhongjie
AU  - Chen, Kai
AU  - Yu, Ye
AU  - Hu, Bo
AU  - Song, Hongsheng
AU  - Liu, Xiaojing
TI  - Transcriptional Dynamics Induced by Diapause Hormone in the Silkworm, Bombyx mori
JF  - BIOLOGY-BASEL
J2  - BIOLOGY-BASEL
VL  - 11
PY  - 2022
IS  - 9
PG  - 14
SN  - 2079-7737
DO  - 10.3390/biology11091313
UR  - https://m2.mtmt.hu/api/publication/33181149
ID  - 33181149
AB  - Simple Summary Most insects species enter a diapause period to ensure their survival under unsuitable environments. In the silkworm, Bombyx mori, diapause occurs at the embryonic stage and is regulated by the diapause hormone (DH). Here, we directly injected DH into the female pupae and investigated the DH receptor expression pattern. Using RNA sequencing, we analyzed the gene expression profile in the developing ovaries after the injection of DH. Diapause is a form of dormancy that organisms use to adapt to extreme environments by exhibiting developmental arrest. In the silkworm, Bombyx mori, diapause is thought to be elicited by diapause hormone (DH) signaling, which consists of interactions between DH and the DH receptor (DHR). However, the steps downstream of the DH signaling pathway are largely unknown. In the present study, we directly injected synthesized DH into the female pupae of a multivoltine, non-diapausing strain at 36 h after pupation. We found that the mRNA level of DHR declined at 4 h and recovered at 12 h after the injection of DH. Thus, we sequenced the transcriptome of the ovaries at 4 h and 12 h after the injection of DH. We identified 60 and 221 differentially expressed genes at 4 h and 12 h after the injection, respectively. All DEGs were identified, relating to 20E-related genes, JH-related genes, cellular detoxification, ribosomal proteins, lipid metabolism, and epigenetic modifications. Eleven genes were selected from the above categories to verify the transcriptome data. The qRT-PCR and RNA-Seq expression patterns of the genes were consistent, which indicated the authenticity and reliability of the transcriptome data. This study dramatically expands upon our knowledge of gene expression variation at the early phase of DH release.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Fernandez-Nicolas, Ana
AU  - Ventos-Alfonso, Alba
AU  - Kamsoi, Orathai
AU  - Clark-Hachtel, Courtney
AU  - Tomoyasu, Yoshinori
AU  - Belles, Xavier
TI  - Broad complex and wing development in cockroaches
JF  - INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
J2  - INSECT BIOCHEM MOLEC
VL  - 147
PY  - 2022
PG  - 9
SN  - 0965-1748
DO  - 10.1016/j.ibmb.2022.103798
UR  - https://m2.mtmt.hu/api/publication/32970497
ID  - 32970497
AB  - In hemimetabolan insects, the transcription factor Broad complex (Br-C) promotes wing growth and development during the nymphal period. We wondered whether Br-C could trigger the initiation of wing development, using the cockroach Blattella germanica as a model. We show that first instar nymphs have their unique identity of these three thoracic segments specified. During embryogenesis, the expression of Br-C and some wing-related genes show two matching waves. The first takes place before the formation of the germ band, which might be involved in the establishment of various developmental fields including a potential "wing field", and the second wave around organogenesis, possibly involved in the initiation of wing development. However, the expression of Br-C in early embryogenesis concentrates in the developing central nervous system, thus not co-localizing with the expression of the typical wing-related gene vestigial, which is expressed at the edge of the thoracic and abdominal segments. This suggests that Br-C is not specifically involved in the establishment of a potential "wing field" in early embryogenesis. Moreover, maternal RNAi for Br-C depletes the first wave of Br-C expression but does not affect the early expression of wing-related genes. As maternal Br-C RNAi did not deplete the second expression wave of Br-C, we could not evaluate if Br-C is involved in the initiation of wing development. Alternatively, using nymphal RNAi of Br-C and Sex combs reduced (Scr), we show that Br-C contributes to the formation of ectopic wing structures that develop in the prothorax when Scr is depleted. The gene most clearly influenced by Br-C RNAi is nubbin (nub), which, in nymphs is crucial for wing growth. Together, these results suggest that Br-C does not specifically contribute to the establishment of the "wing field", but it does seem important later, in the initiation of wing development, enhancing the expression of wing-related genes, especially nub. This supports the hypothesis previously proposed by the authors, whereby Br-C might have facilitated the evolution of holometaboly. However, there is no doubt that other factors have also contributed to this evolution.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Karanja, Faith
AU  - Sahu, Subhshri
AU  - Weintraub, Sara
AU  - Bhandari, Rajan
AU  - Jaszczak, Rebecca
AU  - Sitt, Jason
AU  - Halme, Adrian
TI  - Ecdysone exerts biphasic control of regenerative signaling, coordinating the completion of regeneration with developmental progression
JF  - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
J2  - P NATL ACAD SCI USA
VL  - 119
PY  - 2022
IS  - 5
PG  - 12
SN  - 0027-8424
DO  - 10.1073/pnas.2115017119
UR  - https://m2.mtmt.hu/api/publication/32970498
ID  - 32970498
AB  - In Drosophila melanogaster, loss of regenerative capacity in wing imaginal discs coincides with an increase in systemic levels of the steroid hormone ecdysone, a key coordinator of their developmental progression. Regenerating discs release the relaxin hormone Dilp8 (Drosophila insulin-like peptide 8) to limit ecdysone synthesis and extend the regenerative period. Here, we describe how regenerating tissues produce a biphasic response to ecdysone levels: lower concentrations of ecdysone promote local and systemic regenerative signaling, whereas higher concentrations suppress regeneration through the expression of broad splice isoforms. Ecdysone also promotes the expression of wingless during both regeneration and normal development through a distinct regulatory pathway. This dual role for ecdysone explains how regeneration can still be completed successfully in dilp8(-)mutant larvae: higher ecdysone levels increase the regenerative activity of tissues, allowing regeneration to reach completion in a shorter time. From these observations, we propose that ecdysone hormone signaling functions to coordinate regeneration with developmental progression.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Sun, Ya-Ya
AU  - Fu, Dan-Yang
AU  - Liu, Bin
AU  - Wang, Lin-Jun
AU  - Chen, Hui
TI  - Roles of Kruppel Homolog 1 and Broad-Complex in the Development of Dendroctonus armandi (Coleoptera: Scolytinae)
JF  - FRONTIERS IN PHYSIOLOGY
J2  - FRONT PHYSIOL
VL  - 13
PY  - 2022
PG  - 16
SN  - 1664-042X
DO  - 10.3389/fphys.2022.865442
UR  - https://m2.mtmt.hu/api/publication/32934648
ID  - 32934648
AB  - In insects, metamorphosis is controlled by juvenile hormone (JH) and 20-hydroxyecdysone (20E). Kruppel homolog 1 (Kr-h1), a key JH-early inducible gene, is responsible for the suppression of metamorphosis and the regulation of the Broad-Complex (Br-C) gene, which is induced by 20E and functions as a "pupal specifier". In this study, we identified and characterized the expression patterns and tissue distribution of DaKr-h1 and DaBr-C at various developmental stages of Dendroctonus armandi. The expression of the two genes was induced by JH analog (JHA) methoprene and 20E, and their functions were investigated by RNA interference. DaKr-h1 and DaBr-C were predominantly expressed in the heads of larvae and were significantly downregulated during the molting stage. In contrast, the DaKr-h1 transcript level was highest in the adult anterior midgut. DaBr-C was mainly expressed in female adults, with the highest transcript levels in the ovaries. In the larval and pupal stages, both JHA and 20E significantly induced DaKr-h1, but only 20E significantly induced DaBr-C, indicating the importance of hormones in metamorphosis. DaKr-h1 knockdown in larvae upregulated DaBr-C expression, resulting in precocious metamorphosis from larvae to pupae and the formation of miniature pupae. DaKr-h1 knockdown in pupae suppressed DaBr-C expression, increased emergence, caused abnormal morphology, and caused the formation of small-winged adults. These results suggest that DaKr-h1 is required for the metamorphosis of D. armandi. Our findings provide insight into the roles of DaKr-h1 and DaBr-C in JH-induced transcriptional repression and highlight DaKr-h1 as a potential target for metamorphosis suppression in D. armandi.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Martin, David
AU  - Chafino, Silvia
AU  - Franch-Marro, Xavier
TI  - How stage identity is established in insects: the role of the Metamorphic Gene Network
JF  - CURRENT OPINION IN INSECT SCIENCE
J2  - CURR OPIN INSECT SCI
VL  - 43
PY  - 2021
SP  - 29
EP  - 38
PG  - 10
SN  - 2214-5745
DO  - 10.1016/j.cois.2020.10.002
UR  - https://m2.mtmt.hu/api/publication/32423816
ID  - 32423816
AB  - Proper formation of adult insects requires the integration of spatial and temporal regulatory axes. Whereas spatial information confers identity to each tissue, organ and appendage, temporal information specifies at which stage of development the animal is. Regardless of the type of post embryonic development, either hemimetabolous or holometabolous, temporal specificity is achieved through interactions between the temporal identity genes Kr-h1, E93 and Br-C, whose sequential expression is controlled by the two major developmental hormones, 20-hydroxyecdysone and Juvenile hormone. Given the intimate regulatory connection between these three factors to specify life stage identity, we dubbed the regulatory axis that comprises these genes as the Metamorphic Gene Network (MGN). In this review, we survey the molecular mechanisms underlying the control by the MGN of stage identity and progression in hemimetabolous and holometabolous insects.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Thompson, Barry J.
TI  - From genes to shape during metamorphosis: a history
JF  - CURRENT OPINION IN INSECT SCIENCE
J2  - CURR OPIN INSECT SCI
VL  - 43
PY  - 2021
SP  - 1
EP  - 10
PG  - 10
SN  - 2214-5745
DO  - 10.1016/j.cois.2020.08.008
UR  - https://m2.mtmt.hu/api/publication/32312190
ID  - 32312190
AB  - Metamorphosis (Greek for a state of transcending-form or change-in-shape) refers to a dramatic transformation of an animal's body structure that occurs after development of the embryo or larva in many species. The development of a fly (or butterfly) from a crawling larva (or caterpillar) that forms a pupa (or chrysalis) before eclosing as a flying adult is a classic example of metamorphosis that captures the imagination and has been immortalized in children's books. Powerful genetic experiments in the fruit fly Drosophila melanogaster have revealed how genes can instruct the behaviour of individual cells to control patterns of tissue growth, mechanical force, cell-cell adhesion and cell matrix adhesion drive morphogenetic change in epithelial tissues. Together, the distribution of mass, force and resistance determines cell shape changes, cell-cell rearrangements, and/or the orientation of cell divisions to generate the final form of the tissue. In organising tissue shape, genes harness the power of self-organisation to determine the collective behaviour of molecules and cells, which can often be reproduced in computer simulations of cell polarity and/or tissue mechanics. This review highlights fundamental discoveries in epithelial morphogenesis made by pioneers who were fascinated by metamorphosis, including D'Arcy Thompson, Conrad Waddington, Dianne Fristrom and Antonio Garcia-Bellido.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ali, Md Saheb
AU  - Takaki, Keiko
TI  - Transcriptional regulation of cuticular genes during insect metamorphosis
JF  - FRONTIERS IN BIOSCIENCE-LANDMARK
J2  - FRONT BIOSCI-LANDMARK
VL  - 25
PY  - 2020
SP  - 106
EP  - 117
PG  - 12
SN  - 2768-6701
DO  - 10.2741/4796
UR  - https://m2.mtmt.hu/api/publication/31685453
ID  - 31685453
AB  - In some adult holometabolous insects, specific epithelial tissues form imaginal discs, small sac-like clusters of cells that form in the larval body. During metamorphosis, in response to hormones, the discs undergo dramatic changes including cell proliferation and differentiation. In Bombyx mori insects, the cuticular protein (CP) genes, which are expressed at prepupal stage in the wing discs, are divided into six groups according to their developmental expression profile and responsiveness to steroid hormones. In this article, we discuss the expression of CP genes in the wing disc, and examine the molecular mechanisms by which metamorphosis and cell transformations are regulated by hormones in insects.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ding, Nan
AU  - Wang, Zhiying
AU  - Geng, Nannan
AU  - Zou, Hang
AU  - Zhang, Guocai
AU  - Cao, Chuanwang
AU  - Li, Xingpeng
AU  - Zou, Chuanshan
TI  - Silencing Br-C impairs larval development and chitin synthesis in Lymantria dispar larvae
JF  - JOURNAL OF INSECT PHYSIOLOGY
J2  - J INSECT PHYSIOL
VL  - 122
PY  - 2020
PG  - 10
SN  - 0022-1910
DO  - 10.1016/j.jinsphys.2020.104041
UR  - https://m2.mtmt.hu/api/publication/31466713
ID  - 31466713
AB  - In insects, 20-hydroxyecdysone (20E) mediates developmental transitions and regulates molting processes through activation of a series of transcription factors. Broad-Complex (Br-C), a vital gene in the 20E signalling pathway, plays crucial roles during insect growth processes. However, whether Br-C affects chitin synthesis in insects remains unclear. In the present study, the Br-C gene from Lymantria dispar, a notorious defoliator of forestry, was identified based on transcriptome data, and subjected to bioinformatic analysis. The regulatory functions of LdBr-C in chitin synthesis and metabolism in L. dispar larvae were analysed by RNA interference (RNAi). The full-length LdBr-C gene (1431 bp) encodes a 477 amino acid (aa) polypeptide containing a common BRcore region (391 aa) at the N-terminus and a C-terminal Zinc finger domain (56 aa) harbouring two characteristic C2H2 motifs (CXXC and HXXXXH). Phylogenetic analyses showed that LdBr-C shares highest homology and identity with Br-C isoform 7 (83.12%) of Helicoverpa armigera. Expression profiles indicate that LdBr-C was expressed throughout larval and pupal stages, and highly expressed in prepupal and pupal stages. Furthermore, LdBr-C expression was strongly induced by exogenous 20E, and suppressed dramatically after application of dsLdBr-C. Bioassay results showed that knockdown of LdBr-C caused larval developmental deformity, significant weight loss, and a mortality rate of 67.18%. Knockdown of LdBr-C significantly down-regulated transcription levels of eight critical genes (LdTre1, LdTre2, LdG6PI, LdUAP, LdCHS1, LdCHS2, LdTPS and LdCHT) related to chitin synthesis and metabolism, thereby lowering the chitin content in the midgut and epidermis. Our findings demonstrate that Br-C knockdown impairs larval development and chitin synthesis in L. dispar.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Wu, Yen-Chi
AU  - Chawla, Geetanjali
AU  - Sokol, Nicholas
TI  - let-7-Complex MicroRNAs Regulate Broad-Z3, Which Together with Chinmo Maintains Adult Lineage Neurons in an Immature State
JF  - G3-GENES GENOMES GENETICS
J2  - G3-GENES GENOM GENET
VL  - 10
PY  - 2020
IS  - 4
SP  - 1393
EP  - 1401
PG  - 9
SN  - 2160-1836
DO  - 10.1534/g3.120.401042
UR  - https://m2.mtmt.hu/api/publication/31466711
ID  - 31466711
AB  - During Drosophila melanogaster metamorphosis, arrested immature neurons born during larval development differentiate into their functional adult form. This differentiation coincides with the downregulation of two zinc-finger transcription factors, Chronologically Inappropriate Morphogenesis (Chinmo) and the Z3 isoform of Broad (Br-Z3). Here, we show that br-Z3 is regulated by two microRNAs, let-7 and miR-125, that are activated at the larval-to-pupal transition and are known to also regulate . The br-Z3 3 ' UTR contains functional binding sites for both let-7 and miR-125 that confers sensitivity to both of these microRNAs, as determined by deletion analysis in reporter assays. Forced expression of let-7 and miR-125 miRNAs leads to early silencing of Br-Z3 and Chinmo and is associated with inappropriate neuronal sprouting and outgrowth. Similar phenotypes were observed by the combined but not separate depletion of br-Z3 and . Because persistent Br-Z3 was not detected in let-7-C mutants, this work suggests a model in which let-7 and miR-125 activation at the onset of metamorphosis may act as a failsafe mechanism that ensures the coordinated silencing of both br-Z3 and needed for the timely outgrowth of neurons arrested during larval development. The let-7 and miR-125 binding site sequences are conserved across Drosophila species and possibly other insects as well, suggesting that this functional relationship is evolutionarily conserved.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Belles, Xavier
TI  - Kruppel homolog 1 and E93: The doorkeeper and the key to insect metamorphosis
JF  - ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
J2  - ARCH INSECT BIOCHEM
PY  - 2019
PG  - 8
SN  - 0739-4462
DO  - 10.1002/arch.21609
UR  - https://m2.mtmt.hu/api/publication/30905886
ID  - 30905886
AB  - Insect metamorphosis is regulated by two main hormones: ecdysone (20E), which promotes molting, and juvenile hormone (JH), which inhibits adult morphogenesis. The transduction mechanisms for the respective hormonal signals include the transcription factors Kruppel homolog 1 (Kr-h1) and E93, which are JH- and 20E-dependent, respectively. Kr-h1 is the main effector of the antimetamorphic action of JH, while E93 is a key promoter of metamorphosis. The ancestral regulatory axis of metamorphosis, which operates in insects with hemimetabolan (gradual) metamorphosis and is known as the MEKRE93 pathway, is based on Kr-h1 repression of E93. In the last juvenile stage, when the production of JH dramatically decreases, Kr-h1 expression is almost completely interrupted, E93 becomes upregulated and metamorphosis proceeds. The holometabolan (complete) metamorphosis mode of development includes the peculiar pupal stage, a sort of intermediate between the final larval instar and the adult stage. In holometabolan species, Broad-Complex (BR-C) transcription factors determine the pupal stage and E93 stimulates the expression of BR-C in the prepupa. The MEKRE93 pathway is conserved in holometabolan insects, which have added the E93/BR-C interaction loop to the ancestral (hemimetabolan) pathway during the evolution from hemimetaboly to holometaboly.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Chafino, Silvia
AU  - Urena, Enric
AU  - Casanova, Jordi
AU  - Casacuberta, Elena
AU  - Franch-Marro, Xavier
AU  - Martin, David
TI  - Upregulation of E93 Gene Expression Acts as the Trigger for Metamorphosis Independently of the Threshold Size in the Beetle Tribolium castaneum
JF  - CELL REPORTS
J2  - CELL REP
VL  - 27
PY  - 2019
IS  - 4
SP  - 1039
EP  - +
PG  - 13
SN  - 2211-1247
DO  - 10.1016/j.celrep.2019.03.094
UR  - https://m2.mtmt.hu/api/publication/30905894
ID  - 30905894
AB  - Body size in holometabolous insects is determined by the size at which the juvenile larva undergoes metamorphosis to the pupal stage. To undergo larva-pupa transition, larva must reach a critical developmental checkpoint, the threshold size (TS); however, the molecular mechanisms through which the TS cues this transition remain to be fully characterized. Here, we use the flour beetle Tribolium castaneum to characterize the molecular mechanisms underlying entry into metamorphosis. We found that T. castaneum reaches a TS at the beginning of the last larval instar, which is associated with the downregulation of TcKr-h1 and the upregulation of TcE93 and TcBr-C. Unexpectedly, we found that while there is an association between TS and TcE93 upregulation, it is the latter that constitutes the molecular trigger for metamorphosis initiation. In light of our results, we evaluate the interactions that control the larva-pupa transition and suggest alternative models.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Huang, Jingfei
AU  - Fang, Ling
AU  - Wang, Shuai
AU  - Liu, Xiang
AU  - Chen, Yong
AU  - Chen, Yixin
AU  - Tian, Houjun
AU  - Lin, Shuo
AU  - Tian, Sufen
AU  - Wei, Hui
AU  - Gu, Xiaojun
TI  - Molecular cloning, expression profiling, and functional analysis of a broad-complex isoform 2/3 (Br-Z2/Z3) transcription factor in the diamondback moth, Plutella xylostella (L.)
JF  - ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
J2  - ARCH INSECT BIOCHEM
VL  - 101
PY  - 2019
IS  - 2
PG  - 19
SN  - 0739-4462
DO  - 10.1002/arch.21549
UR  - https://m2.mtmt.hu/api/publication/30905888
ID  - 30905888
AB  - The diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae), is a widespread and destructive pest of cruciferous crops. New strategies for controlling it are needed because it is rapidly developing resistance to conventional pesticides. In insects, transcription factors (TFs) including broad-complex (Br-C) are thought to be useful for insecticide development because they are able to regulate the transcription of functional genes involved in responses to external stimuli including insecticides. In the present study, we cloned and sequenced the open reading frames (ORFs) of three BTB-ZF encoding genes from the diamondback moth deposited in the National Center for Biotechnology Information (NCBI) database under accessions MG753773, MG288674, and MG753772. The lengths of these ORFs were 1,680, 1,428, and 1,647 bp, respectively. The phylogenetic analysis based on the predicted amino acid sequences of ZF domains showed that MG753773 and MG288674 belonged to Z2/Z3 and Z7 of Br-C while MG753772 belonged to Ttk types. In the agreement, the highest expression level of MG753773 occurred during the prepupal stage, MG288674 and MG753772 were expressed during all stages and peaked in the adult and egg stages, respectively. RNA interference silencing of MG753773 in the late third instar larvae significantly decreased survival and pupation of the insects. With precocene II, transcription of MG753773 increased (4x) in the fourth instar larva 24 hr later; 48 hr later the rate of prepupation and pupation was significantly higher. These findings will contribute to the development of new regulators of the growth and development for diamondback moth control.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hyde, Cameron J.
AU  - Elizur, Abigail
AU  - Ventura, Tomer
TI  - The crustacean ecdysone cassette: A gatekeeper for molt and metamorphosis
JF  - JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
J2  - J STEROID BIOCHEM MOL BIOL
VL  - 185
PY  - 2019
SP  - 172
EP  - 183
PG  - 12
SN  - 0960-0760
DO  - 10.1016/j.jsbmb.2018.08.012
UR  - https://m2.mtmt.hu/api/publication/30509203
ID  - 30509203
AB  - Arthropods have long been utilized as models to explore molecular function, and the findings derived from them can be applied throughout metazoa, including as a basis for medical research. This has led to the adoption of many representative insect models beyond Drosophila, as each lends its own unique perspective to questions in endocrinology and genetics. However, non-insect arthropods are yet to be realised for the potential insight they may provide in such studies. The Crustacea are among the most ancient arthropods from which insects descended, comprising a huge variety of life histories and ecological roles. Of the events in a typical crustacean development, metamorphosis is perhaps the most ubiquitous, challenging and highly studied. Despite this, our knowledge of the endocrinology which underpins metamorphosis is rudimentary at best; although several key molecules have been identified and studied in depth, the link between them is quite nebulous and leans heavily on well-explored insect models, which diverged from the Pancrustacea over 450 million years ago. As omics technologies become increasingly accessible, they bring the prospect of explorative molecular research which will allow us to uncover components and pathways unique to crustaceans. This review reconciles known components of crustacean metamorphosis and reflects on our findings in insects to outline a future search space, with focus given to the ecdysone cascade. To expand our knowledge of this ubiquitous endocrine system not only aids in our understanding of crustacean metamorphosis, but also provides a deeper insight into the adaptive capacity of arthropods throughout evolution.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Jindra, Marek
TI  - Where did the pupa come from? The timing of juvenile hormone signalling supports homology between stages of hemimetabolous and holometabolous insects
JF  - PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B - BIOLOGICAL SCIENCES
J2  - PHILOS T ROY SOC B
VL  - 374
PY  - 2019
IS  - 1783
PG  - 10
SN  - 0962-8436
DO  - 10.1098/rstb.2019.0064
UR  - https://m2.mtmt.hu/api/publication/30905883
ID  - 30905883
AB  - Insect metamorphosis boasts spectacular cases of postembryonic development when juveniles undergo massive morphogenesis before attaining the adult form and function; in moths or flies the larvae do not even remotely resemble their adult parents. A selective advantage of complete metamorphosis (holometaboly) is that within one species the two forms with different lifestyles can exploit diverse habitats. It was the environmental adaptation and specialization of larvae, primarily the delay and internalization of wing development, that eventually required an intermediate stage that we call a pupa. It is a long-held and parsimonious hypothesis that the holometabolous pupa evolved through modification of a final juvenile stage of an ancestor developing through incomplete metamorphosis (hemimetaboly). Alternative hypotheses see the pupa as an equivalent of all hemimetabolous moulting cycles (instars) collapsed into one, and consider any preceding holometabolous larval instars free-living embryos stalled in development. Discoveries on juvenile hormone signalling that controls metamorphosis grant new support to the former hypothesis deriving the pupa from a final pre-adult stage. The timing of expression of genes that repress and promote adult development downstream of hormonal signals supports homology between postembryonic stages of hemimetabolous and holometabolous insects.This article is part of the theme issue 'The evolution of complete metamorphosis'.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Truman, James W.
AU  - Riddiford, Lynn M.
TI  - The evolution of insect metamorphosis: a developmental and endocrine view
JF  - PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B - BIOLOGICAL SCIENCES
J2  - PHILOS T ROY SOC B
VL  - 374
PY  - 2019
IS  - 1783
PG  - 12
SN  - 0962-8436
DO  - 10.1098/rstb.2019.0070
UR  - https://m2.mtmt.hu/api/publication/30905881
ID  - 30905881
AB  - Developmental, genetic and endocrine data from diverse taxa provide insight into the evolution of insect metamorphosis. We equate the larva-pupa-adult of the Holometabola to the pronymph-nymph-adult of hemimetabolous insects. The hemimetabolous pronymph is a cryptic embryonic stage with unique endocrinology and behavioural modifications that probably served as preadaptations for the larva. It develops in the absence of juvenile hormone (JH) as embryonic primordia undergo patterning and morphogenesis, the processes that were arrested for the evolution of the larva. Embryonic JH then drives tissue differentiation and nymph formation. Experimental treatment of pronymphs with JH terminates patterning and induces differentiation, mimicking the processes that occurred during the evolution of the larva. Unpatterned portions of primordia persist in the larva, becoming imaginal discs that form pupal and adult structures. Key transcription factors are associated with the holometabolous life stages: Kruppel-homolog 1 (Kr-h1) in the larva, broad in the pupa and E93 in the adult. Kr-h1 mediates JH action and is found whenever JH acts, while the other two genes direct the formation of their corresponding stages. In hemimetabolous forms, the pronymph has low Broad expression, followed by Broad expression through the nymphal moults, then a switch to E93 to form the adult.This article is part of the theme issue 'The evolution of complete metamorphosis'.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Truman, JW
TI  - The evolution of insect metamorphosis
JF  - CURRENT BIOLOGY
J2  - CURR BIOL
VL  - 29
PY  - 2019
IS  - 23
SP  - R1252
EP  - R1268
SN  - 0960-9822
DO  - 10.1016/j.cub.2019.10.009
UR  - https://m2.mtmt.hu/api/publication/31403688
ID  - 31403688
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Uyehara, Christopher M.
AU  - McKay, Daniel J.
TI  - Direct and widespread role for the nuclear receptor EcR in mediating the response to ecdysone in Drosophila
JF  - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
J2  - P NATL ACAD SCI USA
VL  - 116
PY  - 2019
IS  - 20
SP  - 9893
EP  - 9902
PG  - 10
SN  - 0027-8424
DO  - 10.1073/pnas.1900343116
UR  - https://m2.mtmt.hu/api/publication/30905891
ID  - 30905891
AB  - The ecdysone pathway was among the first experimental systems employed to study the impact of steroid hormones on the genome. In Drosophila and other insects, ecdysone coordinates developmental transitions, including wholesale transformation of the larva into the adult during metamorphosis. Like other hormones, ecdysone controls gene expression through a nuclear receptor, which functions as a ligand-dependent transcription factor. Although it is clear that ecdysone elicits distinct transcriptional responses within its different target tissues, the role of its receptor, EcR, in regulating target gene expression is incompletely understood. In particular, EcR initiates a cascade of transcription factor expression in response to ecdysone, making it unclear which ecdysone-responsive genes are direct EcR targets. Here, we use the larval-to-prepupal transition of developing wings to examine the role of EcR in gene regulation. Genome-wide DNA binding profiles reveal that EcR exhibits widespread binding across the genome, including at many canonical ecdysone response genes. However, the majority of its binding sites reside at genes with wing-specific functions. We also find that EcR binding is temporally dynamic, with thousands of binding sites changing over time. RNA-seq reveals that EcR acts as both a temporal gate to block precocious entry to the next developmental stage as well as a temporal trigger to promote the subsequent program. Finally, transgenic reporter analysis indicates that EcR regulates not only temporal changes in target enhancer activity but also spatial patterns. Together, these studies define EcR as a multipurpose, direct regulator of gene expression, greatly expanding its role in coordinating developmental transitions.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Vea, Isabelle Mifom
AU  - Tanaka, Sayumi
AU  - Tsuji, Tomohiro
AU  - Shiotsuki, Takahiro
AU  - Jouraku, Akiya
AU  - Minakuchi, Chieka
TI  - E93 expression and links to the juvenile hormone in hemipteran mealybugs with insights on female neoteny
JF  - INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
J2  - INSECT BIOCHEM MOLEC
VL  - 104
PY  - 2019
SP  - 65
EP  - 72
PG  - 8
SN  - 0965-1748
DO  - 10.1016/j.ibmb.2018.11.008
UR  - https://m2.mtmt.hu/api/publication/30509201
ID  - 30509201
AB  - Insect metamorphosis produces reproductive adults and is commonly accompanied with the direct or indirect development of wings. In some winged insects, the imago is altered by life history changes. For instance, in scale insects and mealybugs, reproductive females retain juvenile features and are wingless. The transcription factor E93 triggers metamorphosis and plays in concert with the juvenile hormone pathway to guarantee the successful transition from juvenile to adult. We previously provided evidence of an atypical down-regulation of the juvenile hormone pathway during female development in the Japanese mealybug. Here, we further investigate how E93 is involved in the production of neotenic wingless females, by identifying its isoforms, assessing their expression patterns and evaluating the effect of exogenous juvenile hormone mimic treatment on E93. This study identifies three E93 isoforms on the 5' end, based on Japanese mealybug cDNA and shows that female development occurs with the near absence of E93 transcripts, as opposed to male metamorphosis. Additionally, while male development is typically affected by exogenous juvenile hormone mimic treatments, females seem to remain insensitive to the treatment, and up-regulation of the juvenile hormone signaling is not observed. Furthermore, juvenile hormone mimic treatment on female nymphs did not have an obvious effect on E93 transcription, while treatment on male prepupae resulted in depleted E93 transcripts. In this study, we emphasize the importance in examining atypical cases of metamorphosis as complementary systems to provide a better understanding on the molecular mechanisms underlying insect metamorphosis. For instance, the factors regulating the expression of E93 are largely unclear. Investigating the regulatory mechanism of E93 transcription could provide clues towards identifying the factors that induce or suppress E93 transcription, in turn triggering male adult development or female neoteny.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Xu, Q-Y
AU  - Meng, Q-W
AU  - Deng, P.
AU  - Fu, K-Y
AU  - Guo, W-C
AU  - Li, G-Q
TI  - Impairment of pupation by RNA interference-aided knockdown of Broad-Complex gene in Leptinotarsa decemlineata (Say)
JF  - BULLETIN OF ENTOMOLOGICAL RESEARCH
J2  - B ENTOMOL RES
VL  - 109
PY  - 2019
IS  - 5
SP  - 659
EP  - 668
PG  - 10
SN  - 0007-4853
DO  - 10.1017/S0007485318001050
UR  - https://m2.mtmt.hu/api/publication/30902363
ID  - 30902363
AB  - Dietary delivery of bacterially expressed double-stranded RNA (dsRNA) has a great potential for management of Leptinotarsa decemlineata. An important first step is to discover possible RNA-interference (RNAi)-target genes effective against larvae, especially the old larvae. In the present paper, five putative Broad-Complex (BrC) cDNAs (Z1-Z4, and Z6) were identified in L. decemlineata. The expression of the five LdBrC isoforms was suppressed by juvenile hormone signaling, whereas the transcription was upregulated by 20-hydroxyecdysone signaling at the fourth (final) instar larval stage. Feeding of bacterially expressed dsBrC (derived from a common fragment of the five LdBrC variants) in the third- and fourth-instar larvae successfully knocked down the target mRNAs. For the fourth-instar LdBrC RNAi hypomorphs, they had a higher larval mortality compared with the controls. Moreover, most dsBrC-fed beetles did not pupate normally. After removal of the apolysed larval cuticle, a miniature adult was found. The adult head, compound eyes, prothorax, mesothorax, metathorax were found on the dorsal view. Distinct adult cuticle pigmentation was seen on the prothorax. The mouthparts, forelegs, midlegs, and hindlegs could be observed on the ventral view of the miniature adults. For the third-instar LdBrC RNAi specimens, around 20% moribund beetles remained as prepupae and finally died. Therefore, LdBrC is among the most attractive candidate genes for RNAi to control the fourth-instar larvae in L. decemlineata.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Xu, Q. -Y.
AU  - Meng, Q. -W.
AU  - Deng, P.
AU  - Fu, K. -Y.
AU  - Guo, W. -C.
AU  - Li, G. -Q.
TI  - Isoform specific roles of Broad-Complex in larval development in Leptinotarsa decemlineata
JF  - INSECT MOLECULAR BIOLOGY
J2  - INSECT MOL BIOL
VL  - 28
PY  - 2019
IS  - 3
SP  - 420
EP  - 430
PG  - 11
SN  - 0962-1075
DO  - 10.1111/imb.12563
UR  - https://m2.mtmt.hu/api/publication/30902364
ID  - 30902364
AB  - Broad-Complex (BrC) is a downstream target of both 20-hydroxyecdysone and juvenile hormone signalling. BrC regulates morphogenetic changes between nymphal instars in hemimetabolans, whereas it controls pupal commitment, pupal morphogenesis and inhibits adult differentiation in holometabolans. Among five BrC cDNAs (Z1-Z4 and Z6) identified in the Colorado potato beetle, we found in this work that Z1, Z2 and Z6 were mainly expressed at the last (fourth) instar and prepupal stages, whereas the levels of Z3 and Z4 increased during the penultimate (third) instar stage, peaked at the last instar larval phase and gradually decreased at the prepupal and pupal periods. When knocking down all BrC isoforms by RNA interference (RNAi) at the penultimate instar stage, around 20% of the resultant larvae remained as moribund beetles. These moribund BrC RNAi larvae were completely or partially wrapped in old cuticle. Likewise, a portion of larvae treated for a single double-stranded RNA of Z3, Z4 or Z6 displayed a degree of similar aberrancies, increasing in the order of isoforms Z6 BrC isoforms at the last instar period, most of the RNAi larvae did not normally pupate or emerge as adults. Separately silencing each of the five zinc finger domains revealed that approximately 70% of the Z1 RNAi larvae remained as prepupae, around 60% of the Z6 RNAi specimens formed aberrant prepupae or pupae and about 60% of the Z2 RNAi beetles became deformed pupae. After removal of the old exuviae, these deformed larvae in which either Z1, Z2 or Z6 was depleted possessed adult prothorax and mesothorax, developing antenna, mouthparts and wing discs. Moreover, less than 50% of the resultant pupae finally emerged as adults when either of Z1, Z2 or Z6 was knocked down. Therefore, our findings reveal, for the first time, that the two roles of BrC in insect groups (ie directing morphogenetic changes during juvenile development and regulating larval-pupal-adult metamorphosis) are played by different BrC isoforms in Leptinotarsa decemlineata.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Diaz-de-la-Loza, Maria-del-Carmen
AU  - Ray, Robert P
AU  - Ganguly, Poulami S
AU  - Alt, Silvanus
AU  - Davis, John R
AU  - Hoppe, Andreas
AU  - Tapon, Nic
AU  - Salbreux, Guillaume
AU  - Thompson, Barry J
TI  - Apical and Basal Matrix Remodeling Control Epithelial Morphogenesis
JF  - DEVELOPMENTAL CELL
J2  - DEV CELL
VL  - 46
PY  - 2018
IS  - 1
SP  - 23
EP  - +
PG  - 22
SN  - 1534-5807
DO  - 10.1016/j.devcel.2018.06.006
UR  - https://m2.mtmt.hu/api/publication/27525173
ID  - 27525173
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Li, Wenchu
AU  - Xu, Yaling
AU  - Zhong, Yangjin
AU  - Chen, Liujuan
TI  - Physiological functions and Ca2+ signal transduction pathway exploring during molting of silkworm, Bombyx mori
JF  - JOURNAL OF ASIA PACIFIC ENTOMOLOGY
J2  - J ASIA PAC ENTOMOL
VL  - 21
PY  - 2018
IS  - 4
SP  - 1457
EP  - 1465
PG  - 9
SN  - 1226-8615
DO  - 10.1016/j.aspen.2018.10.021
UR  - https://m2.mtmt.hu/api/publication/30714105
ID  - 30714105
AB  - Calcium ions are an important second messagers in the life of organisms, such as in silkworm growth and their developmental processes; these ions can trigger various effects, including the muscle excitation-contraction coupling-mechanism, secretion of endocrine and exocrine glands, neuronal activities, midgut nutrients metabolisms, sensory system, enzymatic systems, and acceleration of metabolism activities. This paper reviewed the ecdysis process and mechanisms, where calcium plays an important role in larvae-to-larvae ecdysis and larvae-to-pupae and pupae-to-moth metamorphosis of silkworms; the paper focuses on the advanced achievements in the field of calcium actions during larvae-to-larvae and larvae-to-pupae changes. Calcium ion channels are shown to be the action mechanism of phospholipase C in the G protein cascade of the calcium signal transduction pathway, and the activators and inhibitors of these calcium channels are further discussed.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Miyakawa, Hitoshi
AU  - Sato, Tomomi
AU  - Song, You
AU  - Tollefsen, Knut Erik
AU  - Iguchi, Taisen
TI  - Ecdysteroid and juvenile hormone biosynthesis, receptors and their signaling in the freshwater microcrustacean Daphnia
JF  - JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
J2  - J STEROID BIOCHEM MOL BIOL
VL  - 184
PY  - 2018
SP  - 62
EP  - 68
PG  - 7
SN  - 0960-0760
DO  - 10.1016/j.jsbmb.2017.12.006
UR  - https://m2.mtmt.hu/api/publication/30465803
ID  - 30465803
AB  - The two essential insect hormones, ecdysteroids and juvenile hormones, are possessed not only by insects, but also widely by arthropods, and regulate various developmental and physiological processes. In contrast to the abundant information about molecular endocrine mechanisms in insects, the knowledge of non-insect arthropod endocrinology is still limited. In this review, we summarize recent reports about the molecular basis of these to major insect hormones in the freshwater microcrustacean Daphnia, a keystone taxon in limnetic ecology and bioindicator in environmental studies. Comprehensive comparisons of endocrine signaling pathways between insects and daphnids may shed light on the regulatory mechanisms of various biological phenomena an, moreover, evolutionary processes of arthropod species.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Cao, Jian Q
AU  - Tong, Wai S
AU  - Yu, Hiu Y
AU  - Tobe, Stephen S
AU  - Bendena, William G
AU  - Hui, Jerome H L
ED  - Verlinden, H
TI  - The Role of MicroRNAs in Drosophila Regulation of Insulin-Like Peptides and Ecdysteroid Signalling: Where Are We Now?
JF  - ADVANCES IN INSECT PHYSIOLOGY
J2  - ADV INSECT PHYSIOL
VL  - 53
PY  - 2017
SP  - 55
EP  - 85
PG  - 31
SN  - 0065-2806
DO  - 10.1016/bs.aiip.2017.02.002
UR  - https://m2.mtmt.hu/api/publication/27050162
ID  - 27050162
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kayukawa, Takumi
AU  - Jouraku, Akiya
AU  - Ito, Yuka
AU  - Shinoda, Tetsuro
TI  - Molecular mechanism underlying juvenile hormone-mediated repression of precocious larval-adult metamorphosis
JF  - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
J2  - P NATL ACAD SCI USA
VL  - 114
PY  - 2017
IS  - 5
SP  - 1057
EP  - 1062
PG  - 6
SN  - 0027-8424
DO  - 10.1073/pnas.1615423114
UR  - https://m2.mtmt.hu/api/publication/26537160
ID  - 26537160
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Li, C
AU  - Li, B
AU  - Ma, S
AU  - Lue, P
AU  - Chen, K
TI  - Dusky works upstream of Four-jointed and Forked in wing morphogenesis in Tribolium castaneum
JF  - INSECT MOLECULAR BIOLOGY
J2  - INSECT MOL BIOL
VL  - 26
PY  - 2017
IS  - 6
SP  - 677
EP  - 686
PG  - 10
SN  - 0962-1075
DO  - 10.1111/imb.12327
UR  - https://m2.mtmt.hu/api/publication/27050161
ID  - 27050161
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Song, You
AU  - Villeneuve, Daniel L
AU  - Toyota, Kenji
AU  - Iguchi, Taisen
AU  - Tollefsen, Knut Erik
TI  - Ecdysone Receptor Agonism Leading to Lethal Molting Disruption in Arthropods: Review and Adverse Outcome Pathway Development
JF  - ENVIRONMENTAL SCIENCE & TECHNOLOGY
J2  - ENVIRON SCI TECHNOL
VL  - 51
PY  - 2017
IS  - 8
SP  - 4142
EP  - 4157
PG  - 16
SN  - 0013-936X
DO  - 10.1021/acs.est.7b00480
UR  - https://m2.mtmt.hu/api/publication/26715470
ID  - 26715470
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Uyehara, Christopher M
AU  - Nystrom, Spencer L
AU  - Niederhuber, Matthew J
AU  - Leatham-Jensen, Mary
AU  - Ma, Yiqin
AU  - Buttitta, Laura A
AU  - McKay, Daniel J
TI  - Hormone-dependent control of developmental timing through regulation of chromatin accessibility
JF  - GENES & DEVELOPMENT
J2  - GENE DEV
VL  - 31
PY  - 2017
IS  - 9
SP  - 862
EP  - 875
PG  - 14
SN  - 0890-9369
DO  - 10.1101/gad.298182.117
UR  - https://m2.mtmt.hu/api/publication/26715469
ID  - 26715469
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Yuan, Shenglei
AU  - Huang, Wuren
AU  - Geng, Lei
AU  - Beerntsen, Brenda T
AU  - Song, Hongsheng
AU  - Ling, Erjun
TI  - Differentiation of lepidoptera scale cells from epidermal stem cells followed by ecdysone-regulated DNA duplication and scale secreting
JF  - CELL CYCLE
J2  - CELL CYCLE
VL  - 16
PY  - 2017
IS  - 21
SP  - 2156
EP  - 2167
PG  - 12
SN  - 1538-4101
DO  - 10.1080/15384101.2017.1376148
UR  - https://m2.mtmt.hu/api/publication/27273302
ID  - 27273302
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zhang, X
AU  - Zheng, S
TI  - 20-hydroxyecdysone enhances the expression of the chitinase 5 via Broad-Complex Zinc-Finger 4 during metamorphosis in silkworm, Bombyx mori
JF  - INSECT MOLECULAR BIOLOGY
J2  - INSECT MOL BIOL
VL  - 26
PY  - 2017
IS  - 2
SP  - 243
EP  - 253
PG  - 11
SN  - 0962-1075
DO  - 10.1111/imb.12288
UR  - https://m2.mtmt.hu/api/publication/26537103
ID  - 26537103
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kayukawa, Takumi
AU  - Nagamine, Keisuke
AU  - Ito, Yuka
AU  - Nishita, Yoshinori
AU  - Ishikawa, Yukio
AU  - Shinoda, Tetsuro
TI  - Kruppel Homolog 1 Inhibits Insect Metamorphosis via Direct Transcriptional Repression of Broad-Complex, a Pupal Specifier Gene
JF  - JOURNAL OF BIOLOGICAL CHEMISTRY
J2  - J BIOL CHEM
VL  - 291
PY  - 2016
IS  - 4
SP  - 1751
EP  - 1762
PG  - 12
SN  - 0021-9258
DO  - 10.1074/jbc.M115.686121
UR  - https://m2.mtmt.hu/api/publication/26183633
ID  - 26183633
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Sengupta, S
AU  - Rath, U
AU  - Yao, C
AU  - Zavortink, M
AU  - Wang, C
AU  - Girton, J
AU  - Johansen, KM
AU  - Johansen, J
TI  - Digitor/dASCIZ has multiple roles in Drosophila development
JF  - PLOS ONE
J2  - PLOS ONE
VL  - 11
PY  - 2016
IS  - 11
SN  - 1932-6203
DO  - 10.1371/journal.pone.0166829
UR  - https://m2.mtmt.hu/api/publication/26336417
ID  - 26336417
N1  - Cited By :2            
            Export Date: 18 September 2019            
            CODEN: POLNC
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Urena, Enric
AU  - Chafino, Silvia
AU  - Manjon, Cristina
AU  - Franch-Marro, Xavier
AU  - Martin, David
TI  - The Occurrence of the Holometabolous Pupal Stage Requires the Interaction between E93, Kruppel-Homolog 1 and Broad-Complex
JF  - PLOS GENETICS
J2  - PLOS GENET
VL  - 12
PY  - 2016
IS  - 5
PG  - 24
SN  - 1553-7390
DO  - 10.1371/journal.pgen.1006020
UR  - https://m2.mtmt.hu/api/publication/26051186
ID  - 26051186
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Vea, Isabelle Mifom
AU  - Tanaka, Sayumi
AU  - Shiotsuki, Takahiro
AU  - Jouraku, Akiya
AU  - Tanaka, Toshiharu
AU  - Minakuchi, Chieka
TI  - Differential Juvenile Hormone Variations in Scale Insect Extreme Sexual Dimorphism
JF  - PLOS ONE
J2  - PLOS ONE
VL  - 11
PY  - 2016
IS  - 2
PG  - 18
SN  - 1932-6203
DO  - 10.1371/journal.pone.0149459
UR  - https://m2.mtmt.hu/api/publication/26183632
ID  - 26183632
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bunkuna, Suparin
AU  - Singtripop, Tippawan
AU  - Manaboon, Manaporn
TI  - Juvenile Hormone and Broad-Complex Gene Expression on Programmed Cell Death in the Anterior Silk Glands of the Bamboo Borer (Omphisa fuscidentalis Hampson)
JF  - CHIANG MAI JOURNAL OF SCIENCE
J2  - CHIANG MAI J SCI
VL  - 42
PY  - 2015
IS  - 1
SP  - 126
EP  - 135
PG  - 10
SN  - 0125-2526
UR  - https://m2.mtmt.hu/api/publication/26051190
ID  - 26051190
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Sap, Karen A
AU  - Bezstarosti, Karel
AU  - Dekkers, Dick H W
AU  - van den Hout, Mirjam
AU  - van Ijcken, Wilfred
AU  - Rijkers, Erikjan
AU  - Demmers, Jeroen A A
TI  - Global quantitative proteomics reveals novel factors in the ecdysone signaling pathway in Drosophila melanogaster
JF  - PROTEOMICS
J2  - PROTEOMICS
VL  - 15
PY  - 2015
IS  - 4
SP  - 725
EP  - 738
PG  - 14
SN  - 1615-9853
DO  - 10.1002/pmic.201400308
UR  - https://m2.mtmt.hu/api/publication/26051189
ID  - 26051189
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Cai, MJ
AU  - Liu, W
AU  - Pei, XY
AU  - Li, XR
AU  - He, HJ
AU  - Wang, JX
AU  - Zhao, XF
TI  - Juvenile Hormone Prevents 20-Hydroxyecdysone-induced Metamorphosis by Regulating the Phosphorylation of a Newly Identified Broad Protein
JF  - JOURNAL OF BIOLOGICAL CHEMISTRY
J2  - J BIOL CHEM
VL  - 289
PY  - 2014
IS  - 38
SP  - 26630
EP  - 26641
PG  - 12
SN  - 0021-9258
DO  - 10.1074/jbc.M114.581876
UR  - https://m2.mtmt.hu/api/publication/24280604
ID  - 24280604
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Huang, YC
AU  - Lu, YN
AU  - Wu, JT
AU  - Chien, CT
AU  - Pi, HW
TI  - The COP9 Signalosome Converts Temporal Hormone Signaling to Spatial Restriction on Neural Competence
JF  - PLOS GENETICS
J2  - PLOS GENET
VL  - 10
PY  - 2014
IS  - 11
PG  - 13
SN  - 1553-7390
DO  - 10.1371/journal.pgen.1004760
UR  - https://m2.mtmt.hu/api/publication/24722126
ID  - 24722126
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Nishita, Y
TI  - Ecdysone response elements in the distal promoter of the Bombyx Broad-Complex gene, BmBR-C
JF  - INSECT MOLECULAR BIOLOGY
J2  - INSECT MOL BIOL
VL  - 23
PY  - 2014
IS  - 3
SP  - 341
EP  - 356
PG  - 16
SN  - 0962-1075
DO  - 10.1111/imb.12085
UR  - https://m2.mtmt.hu/api/publication/24092799
ID  - 24092799
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Yang, CW
AU  - Lin, Y
AU  - Liu, HL
AU  - Shen, GW
AU  - Luo, J
AU  - Zhang, HY
AU  - Peng, ZX
AU  - Chen, EX
AU  - Xing, RM
AU  - Han, CS
AU  - Xia, QY
TI  - The Broad Complex isoform 2 (BrC-Z2) transcriptional factor plays a critical role in vitellogenin transcription in the silkworm Bombyx mori
JF  - BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
J2  - BBA-GEN SUBJECTS
VL  - 1840
PY  - 2014
IS  - 9
SP  - 2674
EP  - 2684
PG  - 11
SN  - 0304-4165
DO  - 10.1016/j.bbagen.2014.05.013
UR  - https://m2.mtmt.hu/api/publication/24440760
ID  - 24440760
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Huang, JH
AU  - Lozano, J
AU  - Belles, X
TI  - Broad-complex functions in postembryonic development of the cockroach Blattella germanica shed new light on the evolution of insect metamorphosis
JF  - BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
J2  - BBA-GEN SUBJECTS
VL  - 1830
PY  - 2013
IS  - 1
SP  - 2178
EP  - 2187
PG  - 10
SN  - 0304-4165
DO  - 10.1016/j.bbagen.2012.09.025
UR  - https://m2.mtmt.hu/api/publication/23406490
ID  - 23406490
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Moeller, ME
AU  - Danielsen, ET
AU  - Herder, R
AU  - O'Connor, MB
AU  - Rewitz, KF
TI  - Dynamic feedback circuits function as a switch for shaping a maturation-inducing steroid pulse in Drosophila
JF  - DEVELOPMENT
J2  - DEVELOPMENT
VL  - 140
PY  - 2013
IS  - 23
SP  - 4730
EP  - +
SN  - 0950-1991
UR  - https://m2.mtmt.hu/api/publication/24092801
ID  - 24092801
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ou, QX
AU  - King-Jones, K
TI  - What Goes Up Must Come Down: Transcription Factors Have Their Say in Making Ecdysone Pulses
JF  - CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY
J2  - CURR TOP DEV BIOL
VL  - 103
PY  - 2013
SP  - 35
EP  - 71
PG  - 37
SN  - 0070-2153
DO  - 10.1016/B978-0-12-385979-2.00002-2
UR  - https://m2.mtmt.hu/api/publication/23684202
ID  - 23684202
N1  - BE Shi, YB
Megjegyzés-23406488
BE Shi, YB
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Rewitz, KF
AU  - Yamanaka, N
AU  - O'Connor, MB
TI  - Developmental Checkpoints and Feedback Circuits Time Insect Maturation
JF  - CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY
J2  - CURR TOP DEV BIOL
VL  - 103
PY  - 2013
SP  - 1
EP  - 33
PG  - 33
SN  - 0070-2153
DO  - 10.1016/B978-0-12-385979-2.00001-0
UR  - https://m2.mtmt.hu/api/publication/23406489
ID  - 23406489
N1  - BE Shi, YB
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Rubio, M
AU  - Belles, X
TI  - Subtle roles of microRNAs let-7, miR-100 and miR-125 on wing morphogenesis in hemimetabolan metamorphosis
JF  - JOURNAL OF INSECT PHYSIOLOGY
J2  - J INSECT PHYSIOL
VL  - 59
PY  - 2013
IS  - 11
SP  - 1089
EP  - 1094
PG  - 6
SN  - 0022-1910
DO  - 10.1016/j.jinsphys.2013.09.003
UR  - https://m2.mtmt.hu/api/publication/24092800
ID  - 24092800
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hackney, JF
AU  - Zolali-Meybodi, O
AU  - Cherbas, P
TI  - Tissue Damage Disrupts Developmental Progression and Ecdysteroid Biosynthesis in Drosophila
JF  - PLOS ONE
J2  - PLOS ONE
VL  - 7
PY  - 2012
IS  - 11
SN  - 1932-6203
DO  - 10.1371/journal.pone.0049105
UR  - https://m2.mtmt.hu/api/publication/23406491
ID  - 23406491
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Karatas, A
AU  - Bahceci, Z
AU  - Baspinar, E
TI  - The Effect of Diazinon on Puffing Activity in Polytene Chromosomes of Drosophila melanogaster
JF  - EKOLOJI
J2  - EKOLOJI
VL  - 21
PY  - 2012
IS  - 85
SP  - 98
EP  - 106
PG  - 9
SN  - 1300-1361
DO  - 10.5053/ekoloji.2012.8511
UR  - https://m2.mtmt.hu/api/publication/23406492
ID  - 23406492
LA  - Turkish
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zeng, XK
AU  - Hou, SX
TI  - Broad relays hormone signals to regulate stem cell differentiation in Drosophila midgut during metamorphosis
JF  - DEVELOPMENT
J2  - DEVELOPMENT
VL  - 139
PY  - 2012
IS  - 21
SP  - 3917
EP  - 3925
PG  - 9
SN  - 0950-1991
DO  - 10.1242/dev.083030
UR  - https://m2.mtmt.hu/api/publication/23406493
ID  - 23406493
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Abdou, MA
AU  - He, QY
AU  - Wen, D
AU  - Zyaan, O
AU  - Wang, J
AU  - Xu, JJ
AU  - Baumann, AA
AU  - Joseph, J
AU  - Wilson, TG
AU  - Li, S
AU  - Wang, J
TI  - Drosophila Met and Gce are partially redundant in transducing juvenile hormone action
JF  - INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
J2  - INSECT BIOCHEM MOLEC
VL  - 41
PY  - 2011
IS  - 12
SP  - 938
EP  - 945
PG  - 8
SN  - 0965-1748
DO  - 10.1016/j.ibmb.2011.09.003
UR  - https://m2.mtmt.hu/api/publication/22104027
ID  - 22104027
N1  - Z9: 1
DI: 10.1016/j.ibmb.2011.09.003
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Konopova, B
AU  - Smykal, V
AU  - Jindra, M
TI  - Common and Distinct Roles of Juvenile Hormone Signaling Genes in Metamorphosis of Holometabolous and Hemimetabolous Insects
JF  - PLOS ONE
J2  - PLOS ONE
VL  - 6
PY  - 2011
IS  - 12
SN  - 1932-6203
DO  - 10.1371/journal.pone.0028728
UR  - https://m2.mtmt.hu/api/publication/23406494
ID  - 23406494
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Walker, J
AU  - Kwon, SY
AU  - Badenhorst, P
AU  - East, P
AU  - McNeill, H
AU  - Svejstrup, JQ
TI  - Role of Elongator Subunit Elp3 in Drosophila melanogaster Larval Development and Immunity
JF  - GENETICS
J2  - GENETICS
VL  - 187
PY  - 2011
IS  - 4
SP  - 1067
EP  - 1075
PG  - 9
SN  - 0016-6731
DO  - 10.1534/genetics.110.123893
UR  - https://m2.mtmt.hu/api/publication/22189138
ID  - 22189138
N1  - DI: 10.1534/genetics.110.123893
Megjegyzés-22183066
DI: 10.1534/genetics.110.123893
Megjegyzés-22186164
DI: 10.1534/genetics.110.123893
Megjegyzés-22104026
DI: 10.1534/genetics.110.123893
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Chavoshi, TM
AU  - Moussian, B
AU  - Uv, A
TI  - Tissue-autonomous EcR functions are required for concurrent organ morphogenesis in the Drosophila embryo
JF  - MECHANISMS OF DEVELOPMENT
J2  - MECH DEVELOP
VL  - 127
PY  - 2010
IS  - 5-6
SP  - 308
EP  - 319
PG  - 12
SN  - 0925-4773
DO  - 10.1016/j.mod.2010.01.003
UR  - https://m2.mtmt.hu/api/publication/22104029
ID  - 22104029
N1  - DI: 10.1016/j.mod.2010.01.003
Megjegyzés-22084209
DI: 10.1016/j.mod.2010.01.003
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Dialynas, G
AU  - Speese, S
AU  - Budnik, V
AU  - Geyer, PK
AU  - Wallrath, LL
TI  - The role of Drosophila Lamin C in muscle function and gene expression
JF  - DEVELOPMENT
J2  - DEVELOPMENT
VL  - 137
PY  - 2010
IS  - 18
SP  - 3067
EP  - 3077
PG  - 11
SN  - 0950-1991
DO  - 10.1242/dev.048231
UR  - https://m2.mtmt.hu/api/publication/22104030
ID  - 22104030
N1  - DI: 10.1242/dev.048231
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hiruma, K
AU  - Riddiford, LM
TI  - Developmental expression of mRNAs for epidermal and fat body proteins and hormonally regulated transcription factors in the tobacco hornworm, Manduca sexta
JF  - JOURNAL OF INSECT PHYSIOLOGY
J2  - J INSECT PHYSIOL
VL  - 56
PY  - 2010
IS  - 10
SP  - 1390
EP  - 1395
PG  - 6
SN  - 0022-1910
DO  - 10.1016/j.jinsphys.2010.03.029
UR  - https://m2.mtmt.hu/api/publication/22104032
ID  - 22104032
N1  - DI: 10.1016/j.jinsphys.2010.03.029
Megjegyzés-22239343
Chemicals/CAS: Insect Hormones; Insect Proteins; RNA, Messenger; Transcription Factors
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Liu, DM
AU  - Finley, RL
TI  - Cyclin Y Is a Novel Conserved Cyclin Essential for Development in Drosophila
JF  - GENETICS
J2  - GENETICS
VL  - 184
PY  - 2010
IS  - 4
SP  - 1025
EP  - U232
SN  - 0016-6731
DO  - 10.1534/genetics.110.114017
UR  - https://m2.mtmt.hu/api/publication/23422790
ID  - 23422790
N1  - Megjegyzés-22193542
DI: 10.1534/genetics.110.114017
Megjegyzés-22104033
DI: 10.1534/genetics.110.114017
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Liu, DM
AU  - Guest, S
AU  - Finley, RL
TI  - Why cyclin Y? A highly conserved cyclin with essential functions
JF  - FLY
J2  - FLY
VL  - 4
PY  - 2010
IS  - 4
SP  - 278
EP  - 282
PG  - 5
SN  - 1933-6934
DO  - 10.4161/fly.4.4.12881
UR  - https://m2.mtmt.hu/api/publication/22193535
ID  - 22193535
N1  - DI: 10.4161/fly.4.4.12881
Megjegyzés-22104028
DI: 10.4161/fly.4.4.12881
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Piulachs, MD
AU  - Pagone, V
AU  - Belles, X
TI  - Key roles of the Broad-Complex gene in insect embryogenesis
JF  - INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
J2  - INSECT BIOCHEM MOLEC
VL  - 40
PY  - 2010
IS  - 6
SP  - 468
EP  - 475
PG  - 8
SN  - 0965-1748
DO  - 10.1016/j.ibmb.2010.04.006
UR  - https://m2.mtmt.hu/api/publication/22104031
ID  - 22104031
N1  - DI: 10.1016/j.ibmb.2010.04.006
Megjegyzés-22064608
DI: 10.1016/j.ibmb.2010.04.006
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bernardi, F
AU  - Romani, P
AU  - Tzertzinis, G
AU  - Gargiulo, G
AU  - Cavaliere, V
TI  - Ecr-b1 and usp nuclear hormone receptors regulate expression of the vm32e eggshell gene during drosophila oogenesis
JF  - DEVELOPMENTAL BIOLOGY
J2  - DEV BIOL
VL  - 328
PY  - 2009
IS  - 2
SP  - 541
EP  - 551
PG  - 11
SN  - 0012-1606
DO  - 10.1016/j.ydbio.2009.01.013
UR  - https://m2.mtmt.hu/api/publication/22104035
ID  - 22104035
N1  - DI: 10.1016/j.ydbio.2009.01.013
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Cui, HY
AU  - Lestradet, M
AU  - Bruey-Sedano, N
AU  - Charles, JP
AU  - Riddiford, LM
TI  - Elucidation of the regulation of an adult cuticle gene acp65a by the transcription factor broad
JF  - INSECT MOLECULAR BIOLOGY
J2  - INSECT MOL BIOL
VL  - 18
PY  - 2009
IS  - 4
SP  - 421
EP  - 429
PG  - 9
SN  - 0962-1075
DO  - 10.1111/j.1365-2583.2009.00889.x
UR  - https://m2.mtmt.hu/api/publication/22104034
ID  - 22104034
N1  - DI: 10.1111/j.1365-2583.2009.00889.x
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Spokony, RF
AU  - Restifo, LL
TI  - Broad complex isoforms have unique distributions during central nervous system metamorphosis in drosophila melanogaster
JF  - JOURNAL OF COMPARATIVE NEUROLOGY
J2  - J COMP NEUROL
VL  - 517
PY  - 2009
IS  - 1
SP  - 15
EP  - 36
PG  - 22
SN  - 0021-9967
DO  - 10.1002/cne.22119
UR  - https://m2.mtmt.hu/api/publication/22104036
ID  - 22104036
N1  - DI: 10.1002/cne.22119
Megjegyzés-22064610
DI: 10.1002/cne.22119
Megjegyzés-10072788
FU: National Institutes of Health (NIH) [HD 038363]; National Science
: Foundation (NSF) ; IGERT [DGE 0114420]
FX: Grant sponsor: National Institutes of Health (NIH); Grant number: HD
: 038363 (to L.L.R.); Grant sponsor: National Science Foundation (NSF);
: Grant number: IGERT training grant DGE 0114420 (partial support for
: R.F.S.).
Graduate Interdisciplinary Program in Insect Science, University of Arizona, Tucson, AZ 85721-0108, United States            
            ARL Division of Neurobiology, University of Arizona, 611 Gould-Simpson Bldg., 1040 E. 4th St., Tucson, AZ 85721-0077, United States            
            Department of Neurology, Arizona Health Sciences Center, Tucson, AZ 85724, United States            
            BIO5 Institute for Collaborative Bioresearch, University of Arizona, Tucson, AZ 85721, United States            
            Dept. of Human Genetics, The University of Chicago, 920 E. 58th St., Chicago, IL 60637, United States            
            Cited By :12            
            Export Date: 25 July 2019            
            CODEN: JCNEA            
            Correspondence Address: Restifo, L.L.; ARL Division of Neurobiology, University of Arizona, 611 Gould-Simpson Bldg., 1040 E. 4th St., Tucson, AZ 85721-0077, United States; email: LLR@neurobio.arizona.edu            
            Chemicals/CAS: Drosophila Proteins; Protein Isoforms; Transcription Factors; broad protein, Drosophila
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Wang, HB
AU  - Iwanaga, M
AU  - Kawasaki, H
TI  - Activation of BMWCP10 promoter and regulation by BR-C Z2 in wing disc of Bombyx mori
JF  - INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
J2  - INSECT BIOCHEM MOLEC
VL  - 39
PY  - 2009
IS  - 9
SP  - 615
EP  - 623
PG  - 9
SN  - 0965-1748
DO  - 10.1016/j.ibmb.2009.06.008
UR  - https://m2.mtmt.hu/api/publication/22232168
ID  - 22232168
N1  - Z9: 3 
DI: 10.1016/j.ibmb.2009.06.008
Megjegyzés-22104037
DI: 10.1016/j.ibmb.2009.06.008
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Konopova, B
AU  - Jindra, M
TI  - Broad-complex acts downstream of Met in juvenile hormone signaling to coordinate primitive Holometabolan metamorphosis
JF  - DEVELOPMENT
J2  - DEVELOPMENT
VL  - 135
PY  - 2008
IS  - 3
SP  - 559
EP  - 568
PG  - 10
SN  - 0950-1991
DO  - 10.1242/dev.016097
UR  - https://m2.mtmt.hu/api/publication/22104043
ID  - 22104043
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Minakuchi, C
AU  - Zhou, X
AU  - Riddiford, LM
TI  - Kruppel homolog 1 (Kr-h1) mediates juvenile hormone action during metamorphosis of Drosophila melanogaster
JF  - MECHANISMS OF DEVELOPMENT
J2  - MECH DEVELOP
VL  - 125
PY  - 2008
IS  - 1-2
SP  - 91
EP  - 105
PG  - 15
SN  - 0925-4773
DO  - 10.1016/j.mod.2007.10.002
UR  - https://m2.mtmt.hu/api/publication/22104041
ID  - 22104041
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Muramatsu, D
AU  - Kinjoh, T
AU  - Shinoda, T
AU  - Hiruma, K
TI  - The role of 20-hydroxyecdysone and juvenile hormone in pupal commitment of the epidermis of the silkworm, Bombyx mori
JF  - MECHANISMS OF DEVELOPMENT
J2  - MECH DEVELOP
VL  - 125
PY  - 2008
IS  - 5-6
SP  - 411
EP  - 420
PG  - 10
SN  - 0925-4773
DO  - 10.1016/j.mod.2008.02.001
UR  - https://m2.mtmt.hu/api/publication/22104040
ID  - 22104040
N1  - DI: 10.1016/j.mod.2008.02.001
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Parthasarathy, R
AU  - Tan, A
AU  - Bai, H
AU  - Palli, SR
TI  - Transcription factor broad suppresses precocious development of adult structures during larval-pupal metamorphosis in the red flour beetle, Tribolium castaneum
JF  - MECHANISMS OF DEVELOPMENT
J2  - MECH DEVELOP
VL  - 125
PY  - 2008
IS  - 3-4
SP  - 299
EP  - 313
PG  - 15
SN  - 0925-4773
DO  - 10.1016/j.mod.2007.11.001
UR  - https://m2.mtmt.hu/api/publication/24519438
ID  - 24519438
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Suzuki, Y
AU  - Truman, JW
AU  - Riddiford, LM
TI  - The role of broad in the development of Tribolium castaneum: implications for the evolution of the holometabolous insect pupa
JF  - DEVELOPMENT
J2  - DEVELOPMENT
VL  - 135
PY  - 2008
IS  - 3
SP  - 569
EP  - 577
PG  - 9
SN  - 0950-1991
DO  - 10.1242/dev.015263
UR  - https://m2.mtmt.hu/api/publication/22104039
ID  - 22104039
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zartman, JJ
AU  - Yakoby, N
AU  - Bristow, CA
AU  - Zhou, X
AU  - Schlichting, K
AU  - Dahmann, C
AU  - Shvartsman, SY
TI  - Cad74A is regulated by BR and is required for robust dorsal appendage formation in Drosophila oogenesis
JF  - DEVELOPMENTAL BIOLOGY
J2  - DEV BIOL
VL  - 322
PY  - 2008
IS  - 2
SP  - 289
EP  - 301
PG  - 13
SN  - 0012-1606
DO  - 10.1016/j.ydbio.2008.07.027
UR  - https://m2.mtmt.hu/api/publication/22104042
ID  - 22104042
N1  - DI: 10.1016/j.ydbio.2008.07.027
Megjegyzés-22064611
DI: 10.1016/j.ydbio.2008.07.027
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Spokony, RF
AU  - Restifo, LL
TI  - Anciently duplicated Broad Complex exons have distinct temporal functions during tissue morphogenesis
JF  - DEVELOPMENT GENES AND EVOLUTION
J2  - DEV GENES EVOL
VL  - 217
PY  - 2007
IS  - 7
SP  - 499
EP  - 513
PG  - 15
SN  - 0949-944X
DO  - 10.1007/s00427-007-0159-y
UR  - https://m2.mtmt.hu/api/publication/22104046
ID  - 22104046
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zhou, D
AU  - Xue, J
AU  - Chen, JM
AU  - Morcillo, P
AU  - Lambert, JD
AU  - White, KP
AU  - Haddad, GG
TI  - Experimental selection for drosophila survival in extremely low o-2 environment
JF  - PLOS ONE
J2  - PLOS ONE
VL  - 2
PY  - 2007
IS  - 5
SP  - e490
SN  - 1932-6203
DO  - 10.1371/journal.pone.0000490
UR  - https://m2.mtmt.hu/api/publication/22104044
ID  - 22104044
N1  - DI: 10.1371/journal.pone.0000490
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zhu, JS
AU  - Chen, L
AU  - Raikhel, AS
TI  - Distinct Roles of Broad Isoforms in Regulation of The 20-hydroxyecdysone Effector Gene, Vitellogenin, in The Mosquito Aedes Aegypti
JF  - MOLECULAR AND CELLULAR ENDOCRINOLOGY
J2  - MOL CELL ENDOCRINOL
VL  - 267
PY  - 2007
SP  - 97
EP  - 105
PG  - 9
SN  - 0303-7207
DO  - 10.1016/j.mce.2007.01.006
UR  - https://m2.mtmt.hu/api/publication/22104045
ID  - 22104045
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Basso, LR
AU  - Neves, MD
AU  - Monesi, N
AU  - Paco-Larson, ML
TI  - Broad-Complex, E74, and E75 early genes control DNA puff BhC4-1 expression in prepupal salivary glands
JF  - GENESIS: THE JOURNAL OF GENETICS AND DEVELOPMENT
J2  - GENESIS
VL  - 44
PY  - 2006
IS  - 11
SP  - 505
EP  - 514
PG  - 10
SN  - 1526-954X
DO  - 10.1002/dvg.20239
UR  - https://m2.mtmt.hu/api/publication/23389046
ID  - 23389046
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Fortier, T M
AU  - Chatterjee, R
AU  - Klinedinst, S
AU  - Baehrecke, E H
AU  - Woodard, C T
TI  - how functions in leg development during Drosophila metamorphosis
JF  - DEVELOPMENTAL DYNAMICS
J2  - DEV DYNAM
VL  - 235
PY  - 2006
SP  - 2248
EP  - 2259
PG  - 12
SN  - 1058-8388
DO  - 10.1002/dvdy.20852
UR  - https://m2.mtmt.hu/api/publication/22104048
ID  - 22104048
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Gui, Z Z
AU  - Lee, K S
AU  - Kim, B Y
AU  - Choi, Y S
AU  - Wei, Y D
AU  - Choo, Y M
AU  - Kang, P D
AU  - Yoon, H J
AU  - Kim, I
AU  - Je, Y H
AU  - Seo, S J
AU  - Lee, S M
AU  - Guo, X J
AU  - Sohn, H D
AU  - Jin, B R
TI  - Functional role of aspartic proteinase cathepsin D in insect metamorphosis
JF  - BMC DEVELOPMENTAL BIOLOGY
J2  - BMC DEV BIOL
VL  - 6
PY  - 2006
SN  - 1471-213X
DO  - 10.1186/1471-213X/6/49
UR  - https://m2.mtmt.hu/api/publication/22104049
ID  - 22104049
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Palanker, L
AU  - Necakov, A S
AU  - Sampson, H M
AU  - Ni, R
AU  - Hu, C
AU  - Thummel, C S
AU  - Krause, H M
TI  - Dynamic regulation of Drosophila nuclear receptor activity in vivo
JF  - DEVELOPMENT
J2  - DEVELOPMENT
VL  - 133
PY  - 2006
SP  - 3549
EP  - 3562
PG  - 14
SN  - 0950-1991
DO  - 10.1242/dev.02512
UR  - https://m2.mtmt.hu/api/publication/22104050
ID  - 22104050
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Wilson, TG
AU  - Yerushalmi, Y
AU  - Donnell, DM
AU  - Restifo, L
TI  - Interaction between hormonal signaling pathways in Drosophila melanogaster as revealed by genetic interaction between Methoprene-tolerant and Broad-Complex
JF  - GENETICS
J2  - GENETICS
VL  - 172
PY  - 2006
SP  - 253
EP  - 264
PG  - 12
SN  - 0016-6731
DO  - 10.1534/genetics.105.046631
UR  - https://m2.mtmt.hu/api/publication/22192528
ID  - 22192528
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Beckstead, RB
AU  - Lam, G
AU  - Thummel, CS
TI  - The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis
JF  - GENOME BIOLOGY
J2  - GENOME BIOL
VL  - 6
PY  - 2005
IS  - 12
SN  - 1474-7596
DO  - 10.1186/gb-2005-6-12-r99
UR  - https://m2.mtmt.hu/api/publication/22104053
ID  - 22104053
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Berger, EM
AU  - Dubrovsky, EB
TI  - Juvenile hormone molecular actions and interactions during development of Drosophila melanogaster
JF  - VITAMINS AND HORMONES-ADVANCES IN RESEARCH AND APPLICATIONS
J2  - VITAM HORM
VL  - 73
PY  - 2005
SP  - 175
EP  - 215
PG  - 41
SN  - 0083-6729
DO  - 10.1016/S0083-6729(05)73006-5
UR  - https://m2.mtmt.hu/api/publication/23438552
ID  - 23438552
N1  - BE Litwack, GL
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Consoulas, C
AU  - Levine, RB
AU  - Restifo, LL
TI  - The steroid hormone-regulated gene Broad Complex is required for dendritic growth of motoneurons during metamorphosis of Drosophila
JF  - JOURNAL OF COMPARATIVE NEUROLOGY
J2  - J COMP NEUROL
VL  - 485
PY  - 2005
IS  - 4
SP  - 321
EP  - 337
PG  - 17
SN  - 0021-9967
DO  - 10.1002/cne.20499
UR  - https://m2.mtmt.hu/api/publication/23208875
ID  - 23208875
N1  - ARL Division of Neurobiology, University of Arizona, Tucson, AZ 85721, United States            
            Lab. of Experimental Physiology, University of Athens Medical School, 11527 Athens, Greece            
            Department of Physiology, Arizona Health Sciences Center, Tucson, AZ 85724, United States            
            Department of Neurology, Arizona Health Sciences Center, Tucson, AZ 85724, United States            
            ARLDN, 611 Gould-Simpson Bldg., University of Arizona, 1040 E. 4th St., Tucson, AZ 85721-0077, United States            
            Cited By :22            
            Export Date: 11 February 2022            
            CODEN: JCNEA            
            Correspondence Address: Restifo, L.L.; ARLDN, 1040 E. 4th St., Tucson, AZ 85721-0077, United States; email: LLR@neurobio.arizona.edu
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Davis, MB
AU  - Carney, GE
AU  - Robertson, AE
AU  - Bender, M
TI  - Phenotypic analysis of EcR-A mutants suggests that EcR isoforms have unique functions during Drosophila development
JF  - DEVELOPMENTAL BIOLOGY
J2  - DEV BIOL
VL  - 282
PY  - 2005
SP  - 385
EP  - 396
PG  - 12
SN  - 0012-1606
DO  - 10.1016/j.ydbio.2005.03.019
UR  - https://m2.mtmt.hu/api/publication/22104055
ID  - 22104055
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - King-Jones, K
AU  - Charles, J P
AU  - Lam, G
AU  - Thummel, C S
TI  - The ecdysone-induced DHR4 orphan nuclear receptor coordinates growth and maturation in Drosophila
JF  - CELL
J2  - CELL
VL  - 121
PY  - 2005
IS  - 5
SP  - 773
EP  - 784
PG  - 12
SN  - 0092-8674
DO  - 10.1016/j.cell.2005.03.030
UR  - https://m2.mtmt.hu/api/publication/21071323
ID  - 21071323
N1  - Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, 15 N 2030 E, Salt Lake City, UT 84112, United States            
            Université de Bourgogne, UMR CNRS 5548, Faculté des Sciences Gabriel, 6, Bd Gabriel, 21000 Dijon, France            
            Cited By :83            
            Export Date: 18 October 2022            
            CODEN: CELLB            
            Correspondence Address: Thummel, C.S.; Howard Hughes Medical Institute, 15 N 2030 E, Salt Lake City, UT 84112, United States; email: carl.thummel@genetics.utah.edu
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Mirth, C
TI  - Ecdysteroid control of metamorphosis in the differentiating adult leg structures of Drosophila melanogaster
JF  - DEVELOPMENTAL BIOLOGY
J2  - DEV BIOL
VL  - 278
PY  - 2005
SP  - 163
EP  - 174
PG  - 12
SN  - 0012-1606
DO  - 10.1016/j.ydbio.2004.10.026
UR  - https://m2.mtmt.hu/api/publication/22104058
ID  - 22104058
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Schubiger, M
AU  - Carre, C
AU  - Antoniewski, C
AU  - Truman, JW
TI  - Ligand-dependent de-repression via EcR/USP acts as a gate to coordinate the differentiation of sensory neurons in the Drosophila wing
JF  - DEVELOPMENT
J2  - DEVELOPMENT
VL  - 132
PY  - 2005
SP  - 5239
EP  - 5248
PG  - 10
SN  - 0950-1991
DO  - 10.1242/dev.02093
UR  - https://m2.mtmt.hu/api/publication/22104056
ID  - 22104056
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Chen, L
AU  - Zhu, J
AU  - Sun, G
AU  - Raikhel, AS
TI  - The early gene Broad is involved in the ecdysteroid hierarchy governing vitellogenesis of the mosquito Aedes aegypti
JF  - JOURNAL OF MOLECULAR ENDOCRINOLOGY
J2  - J MOL ENDOCRINOL
VL  - 33
PY  - 2004
SP  - 743
EP  - 761
PG  - 19
SN  - 0952-5041
DO  - 10.1677/jme.1.01531
UR  - https://m2.mtmt.hu/api/publication/22104060
ID  - 22104060
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Poels, J
AU  - Vanden, Broeck J
TI  - Insect basic leucine zipper proteins and their role in cyclic AMP-dependent regulation of gene expression
JF  - INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY
J2  - INT REV CYTOL
VL  - 241
PY  - 2004
SP  - 277
EP  - 309
PG  - 33
SN  - 0074-7696
DO  - 10.1016/S0074-7696(04)41005-5
UR  - https://m2.mtmt.hu/api/publication/21291967
ID  - 21291967
N1  - SE: INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Reza, Ams
AU  - Kanamori, Y
AU  - Shinoda, T
AU  - Shimura, S
AU  - Mita, K
AU  - Nakahara, Y
AU  - Kiuchi, M
AU  - Kamimura, M
TI  - Hormonal control of a metamorphosis-specific transcriptional factor Broad-Complex in silkworm
JF  - COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
J2  - COMP BIOCHEM PHYS B
VL  - 139
PY  - 2004
SP  - 753
EP  - 761
PG  - 9
SN  - 1096-4959
DO  - 10.1016/j.cbpc.2004.09.009
UR  - https://m2.mtmt.hu/api/publication/22104063
ID  - 22104063
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Wilson, TG
TI  - The molecular site of action of juvenile hormone and juvenile hormone insecticides during metamorphosis: how these compounds kill insects
JF  - JOURNAL OF INSECT PHYSIOLOGY
J2  - J INSECT PHYSIOL
VL  - 50
PY  - 2004
SP  - 111
EP  - 121
PG  - 11
SN  - 0022-1910
DO  - 10.1016/j.jinsphys.2003.12.004
UR  - https://m2.mtmt.hu/api/publication/22104059
ID  - 22104059
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zhou, XF
AU  - Zhou, BH
AU  - Truman, JW
AU  - Riddiford, LM
TI  - Overexpression of broad: a new insight into its role in the Drosophila prothoracic gland cells
JF  - JOURNAL OF EXPERIMENTAL BIOLOGY
J2  - J EXP BIOL
VL  - 207
PY  - 2004
SP  - 1151
EP  - 1161
PG  - 11
SN  - 0022-0949
DO  - 10.1242/jeb.00855
UR  - https://m2.mtmt.hu/api/publication/22104061
ID  - 22104061
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bayer, C
AU  - Zhou, XF
AU  - Zhou, BH
AU  - Riddiford, LM
AU  - von Kalm, L
TI  - Evolution of the Drosophila broad locus: the Manduca sexta broad Z4 isoform has biological activity in Drosophila
JF  - DEVELOPMENT GENES AND EVOLUTION
J2  - DEV GENES EVOL
VL  - 213
PY  - 2003
SP  - 471
EP  - 476
PG  - 6
SN  - 0949-944X
DO  - 10.1007/s00427-003-0354-4
UR  - https://m2.mtmt.hu/api/publication/22104070
ID  - 22104070
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bayer, CA
AU  - Halsell, SR
AU  - Fristrom, JW
AU  - Kiehart, DP
AU  - von Kalm, L
TI  - Genetic interactions between the RhoA and stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis
JF  - GENETICS
J2  - GENETICS
VL  - 165
PY  - 2003
SP  - 1417
EP  - 1432
PG  - 16
SN  - 0016-6731
UR  - https://m2.mtmt.hu/api/publication/22104069
ID  - 22104069
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Fortier, TA
AU  - Vasa, PP
AU  - Woodard, CT
TI  - Orphan nuclear receptor beta FTZ-F1 is required for muscle-driven morphogenetic events at the prepupal-pupal transition in Drosophila melanogaster
JF  - DEVELOPMENTAL BIOLOGY
J2  - DEV BIOL
VL  - 257
PY  - 2003
SP  - 153
EP  - 165
PG  - 13
SN  - 0012-1606
DO  - 10.1016/S0012-1606(03)00036-8
UR  - https://m2.mtmt.hu/api/publication/22104066
ID  - 22104066
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Sernpere, LF
AU  - Sokol, NS
AU  - Dubrovsky, EB
AU  - Berger, EM
AU  - Ambros, V
TI  - Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity
JF  - DEVELOPMENTAL BIOLOGY
J2  - DEV BIOL
VL  - 259
PY  - 2003
SP  - 9
EP  - 18
PG  - 10
SN  - 0012-1606
DO  - 10.1016/S0012-1606(03)00208-2
UR  - https://m2.mtmt.hu/api/publication/22104065
ID  - 22104065
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Stilwell, GE
AU  - Nelson, CA
AU  - Weller, J
AU  - Cui, HY
AU  - Hiruma, K
AU  - Truman, JW
AU  - Riddiford, LM
TI  - E74 exhibits stage-specific hormonal regulation in the epidermis of the tobacco hornworm, Manduca sexta
JF  - DEVELOPMENTAL BIOLOGY
J2  - DEV BIOL
VL  - 258
PY  - 2003
SP  - 76
EP  - 90
PG  - 15
SN  - 0012-1606
DO  - 10.1016/S0012-1606(03)00105-2
UR  - https://m2.mtmt.hu/api/publication/22104071
ID  - 22104071
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Uhlirova, M
AU  - Foy, BD
AU  - Beaty, BJ
AU  - Olson, KE
AU  - Riddiford, LM
AU  - Jindra, M
TI  - Use of Sindbis virus-mediated RNA interference to demonstrate a conserved role of Broad-Complex in insect metamorphosis
JF  - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
J2  - P NATL ACAD SCI USA
VL  - 100
PY  - 2003
SP  - 15607
EP  - 15612
PG  - 6
SN  - 0027-8424
DO  - 10.1073/pnas.2136837100
UR  - https://m2.mtmt.hu/api/publication/22104064
ID  - 22104064
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ward, RE
AU  - Evans, J
AU  - Thummel, CS
TI  - Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis
JF  - GENETICS
J2  - GENETICS
VL  - 165
PY  - 2003
SP  - 1397
EP  - 1415
PG  - 19
SN  - 0016-6731
UR  - https://m2.mtmt.hu/api/publication/22131160
ID  - 22131160
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ward, RE
AU  - Reid, P
AU  - Bashirullah, A
AU  - D, Avino PP
AU  - Thummel, CS
TI  - GFP in living animals reveals dynamic developmental responses to ecdysone during Drosophila metamorphosis
JF  - DEVELOPMENTAL BIOLOGY
J2  - DEV BIOL
VL  - 256
PY  - 2003
SP  - 389
EP  - 402
PG  - 14
SN  - 0012-1606
DO  - 10.1016/S0012-1606(02)00100-8
UR  - https://m2.mtmt.hu/api/publication/22104067
ID  - 22104067
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bialecki, M
AU  - Shilton, A
AU  - Fichtenberg, C
AU  - Segraves, WA
AU  - Thummel, CS
TI  - Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila
JF  - DEVELOPMENTAL CELL
J2  - DEV CELL
VL  - 3
PY  - 2002
SP  - 209
EP  - 220
PG  - 12
SN  - 1534-5807
DO  - 10.1016/S1534-5807(02)00204-6
UR  - https://m2.mtmt.hu/api/publication/22104073
ID  - 22104073
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Chen, L
AU  - Keefe, SL
AU  - Hodgetts, RB
TI  - Control of Dopa decarboxylase gene expression by the Broad- Complex during metamorphosis in Drosophila
JF  - MECHANISMS OF DEVELOPMENT
J2  - MECH DEVELOP
VL  - 119
PY  - 2002
SP  - 145
EP  - 156
PG  - 12
SN  - 0925-4773
DO  - 10.1016/S0925-4773(02)00346-5
UR  - https://m2.mtmt.hu/api/publication/22104079
ID  - 22104079
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Chen, L
AU  - Reece, C
AU  - Keefe, SL
AU  - Hawryluk, Gwl
AU  - Engstrom, MM
AU  - Hodgetts, RB
TI  - Induction of the early-late Ddc gene during Drosophila metamorphosis by the ecdysone receptor
JF  - MECHANISMS OF DEVELOPMENT
J2  - MECH DEVELOP
VL  - 114
PY  - 2002
SP  - 95
EP  - 107
PG  - 13
SN  - 0925-4773
DO  - 10.1016/S0925-4773(02)00064-3
UR  - https://m2.mtmt.hu/api/publication/22104075
ID  - 22104075
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Dunne, JC
AU  - Kondylis, V
AU  - Rabouille, C
TI  - Ecdysone triggers the expression of Golgi genes in Drosophila imaginal discs via Broad-complex
JF  - DEVELOPMENTAL BIOLOGY
J2  - DEV BIOL
VL  - 245
PY  - 2002
SP  - 172
EP  - 186
PG  - 15
SN  - 0012-1606
DO  - 10.1006/dbio.2002.0632
UR  - https://m2.mtmt.hu/api/publication/22104077
ID  - 22104077
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Gonzy, G
AU  - Pokholkova, GV
AU  - Peronnet, F
AU  - Mugat, B
AU  - Demakova, OV
AU  - Kotlikova, IV
AU  - Lepesant, JA
AU  - Zhimulev, IF
TI  - Isolation and characterization of novel mutations of the Broad-Complex, a key regulatory gene of ecdysone induction in Drosophila melanogaster
JF  - INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
J2  - INSECT BIOCHEM MOLEC
VL  - 32
PY  - 2002
IS  - 2
SP  - 121
EP  - 132
PG  - 12
SN  - 0965-1748
DO  - 10.1016/S0965-1748(01)00097-2
UR  - https://m2.mtmt.hu/api/publication/23406495
ID  - 23406495
LA  - English
DB  - MTMT
ER  -