TY - JOUR AU - Crespi, C.M. AU - Sudan, M. AU - Juutilainen, J. AU - Roivainen, P. AU - Hareuveny, R. AU - Huss, A. AU - Kandel, S. AU - Karim-Kos, H.E. AU - Thuróczy, G. AU - Jakab, Zsuzsanna AU - Spycher, B.D. AU - Flueckiger, B. AU - Vermeulen, R. AU - Vergara, X. AU - Kheifets, L. TI - International study of childhood leukemia in residences near electrical transformer rooms JF - ENVIRONMENTAL RESEARCH J2 - ENVIRON RES VL - 249 PY - 2024 PG - 7 SN - 0013-9351 DO - 10.1016/j.envres.2024.118459 UR - https://m2.mtmt.hu/api/publication/34745401 ID - 34745401 LA - English DB - MTMT ER - TY - JOUR AU - Garami, Miklós AU - Jakab, Zsuzsanna TI - Nemzeti Gyermekonkológiai Regiszter JF - ORVOSI HETILAP J2 - ORV HETIL VL - 165 PY - 2024 IS - 24-25 SP - 933 EP - 943 PG - 11 SN - 0030-6002 DO - 10.1556/650.2024.33061 UR - https://m2.mtmt.hu/api/publication/35057757 ID - 35057757 N1 - A Szerzők a dolgozatukat Schuler Dezső gyermekgyógyász és genetikus professzor (1927-2020), a hazai Gyermekonkológiai Regiszter megalkotója emlékének ajánlják. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Müller, Judit AU - Szűcs-Farkas, Dóra AU - Szegedi, István AU - Csóka, Monika AU - Garami, Miklós AU - Tiszlavicz, Lilla Györgyi AU - Hauser, Péter AU - Kriván, Gergely AU - Csanádi, Krisztina AU - Ottóffy, Gábor AU - Nagy, Béla AU - Kiss, Csongor AU - Kovács, Gábor TI - Clinical Course of COVID-19 Disease in Children Treated With Neoplastic Diseases in Hungary JF - PATHOLOGY AND ONCOLOGY RESEARCH J2 - PATHOL ONCOL RES VL - 28 PY - 2022 PG - 6 SN - 1219-4956 DO - 10.3389/pore.2022.1610261 UR - https://m2.mtmt.hu/api/publication/32769159 ID - 32769159 N1 - * Megosztott szerzőség AB - We report on children with cancer in Hungary suffering from COVID-19, surveying a 13-months-long period of time. We performed a retrospective clinical trial studying the medical documentation of children treated in seven centers of the Hungarian Pediatric Oncology-Hematology Group. About 10% of children admitted to tertiary hemato-oncological centers for anti-neoplastic treatment or diagnosis for de novo malignancies were positive for SARS-CoV-2 infection. Nearly two-thirds of the infected patients were asymptomatic or had only mild symptoms but showed seropositivity by 1-4.5 months after positive PCR. One third of the SARS-CoV-2-positive children were hospitalized due to symptomatic COVID-19. Five children required antiviral treatment with remdesivir. One child was referred to the intensive care unit, requiring intubation and mechanical ventilation. Delay in the scheduled anti-cancer treatment did not exceed 2 weeks in the majority (89%) of cases. There was only one patient requiring treatment deferral longer than a month. There was no COVID-19-related death in patients under 18 years of age, and nor was multisystem inflammatory syndrome diagnosed. In conclusion, SARS-CoV-2 infection did not represent an untoward risk factor among children with cancer in Hungary. LA - English DB - MTMT ER - TY - JOUR AU - Bertuccio, Paola AU - Alicandro, Gianfranco AU - Malvezzi, Matteo AU - Carioli, Greta AU - Boffetta, Paolo AU - Levi, Fabio AU - La Vecchia, Carlo AU - Negri, Eva TI - Childhood cancer mortality trends in Europe, 1990-2017, with focus on geographic differences JF - CANCER EPIDEMIOLOGY J2 - CANCER EPIDEMIOL VL - 67 PY - 2020 PG - 10 SN - 1877-7821 DO - 10.1016/j.canep.2020.101768 UR - https://m2.mtmt.hu/api/publication/31701237 ID - 31701237 AB - Aim: To monitor trends in childhood cancer mortality in Europe.Methods: We calculated age-standardized mortality rates per 100,000 children (age 0-14 years) from 1990 to the last available calendar year, for all neoplasms and six main cancers in childhood, in selected European countries and geographic areas, plus the European Union (EU), using data from the World Health Organization database. We carried out a joinpoint regression analysis of mortality trends for all neoplasms, leukaemia and tumours of the nervous system.Results of the joinpoint regression were summarized through annual percent change (APC) for each identified linear segment, and weighted average APC (AAPC) over the whole period.Results: From 1990 to 2015, childhood total cancer mortality rates dropped by 2.8% per year in the EU, to reach 2.6/100,000 in the latest available calendar years. The greatest declines were in central-eastern countries (AAPCs -3% to -4%). Recent rates ranged between 1.7 and 4.3 deaths/100,000, with the highest values in central-eastern Europe. Leukaemia mortality rates in the EU decreased from 1.6 to 0.6/100,000 in the latest calendar years (AAPC -4%). The deepest declines were registered in central-eastern countries, though they still showed the highest rates (0.9). The lowest leukaemia mortality rates were in northern-western Europe (0.5/100,000), but also in the Czech Republic and Poland. Southern European countries showed comparatively high rates (0.8). Nervous system tumours showed relatively modest falls (AAPC: -1.7% in the EU).Conclusions: Childhood cancer mortality continued to decline steady in Europe, though geographic differences persist. Further efforts are required to fill the gap, by promoting widespread and rational adoption of currently available treatment protocols. LA - English DB - MTMT ER - TY - JOUR AU - Jakab, Zsuzsanna AU - Garami, Miklós AU - Bartyik, Katalin AU - Csóka, Monika AU - Erdélyi, Dániel AU - Hauser, Péter AU - Juhász, Attila AU - Kelemen, Agnes AU - Kriván, Gergely AU - Masat, Peter AU - Müller, Judit AU - Nagy, Csilla AU - Peter, Gyorgy AU - Rényi, Imre AU - Szegedi, István AU - Vojcek, Ágnes AU - Zombori, Marianna AU - Bardi, Edit AU - Kovács, Gábor TI - Late mortality in survivors of childhood cancer in Hungary JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 10 PY - 2020 IS - 1 PG - 9 SN - 2045-2322 DO - 10.1038/s41598-020-67444-1 UR - https://m2.mtmt.hu/api/publication/31337068 ID - 31337068 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Jakab, Zsuzsanna AU - Juhász, Attila AU - Nagy, Csilla AU - Schuler, Dezső AU - Garami, Miklós TI - Trends and territorial inequalities of incidence and survival of childhood leukaemia and their relations to socioeconomic status in Hungary, 1971-2015 JF - EUROPEAN JOURNAL OF CANCER PREVENTION J2 - EUR J CANCER PREV VL - 26 PY - 2017 SP - S183 EP - S190 SN - 0959-8278 DO - 10.1097/CEJ.0000000000000386 UR - https://m2.mtmt.hu/api/publication/3250870 ID - 3250870 N1 - Hungarian Childhood Cancer Registry, 2nd Department of Paediatrics, Semmelweis University, Hungary Public Health Administration Service of Government Office of Capital City Budapest, Budapest, Hungary Cited By :15 Export Date: 5 March 2024 CODEN: EJUPE Correspondence Address: Jakab, Z.; Hungarian Childhood Cancer Registry, 7-9 Tuzolto Street, Hungary; email: dr.jakab.zsuzsa@gmail.com AB - The Hungarian Childhood Cancer Registry, a population-based national registry of the Hungarian Paediatric Haemato-Oncology Network founded in 1971, monitors the incidence and mortality of childhood cancer. Our aims were to carry out a longitudinal study to investigate the trends and spatial inequalities of incidence and survival of leukaemia, and the association between survival and deprivation in Hungary. All cases of childhood leukaemia and myelodysplasia were analysed (3157 cases, 1971-2015, age: 0-14 years). Time trends and the annual percentage change in direct standardized incidence and mortality were assessed. Survival and association with deprivation were assessed using the Kaplan-Meier method and Cox regression. Incidence rates of leukaemia (23.5-56.0/million) increased with an average annual percent change (AAPC) of 1%, determined by an increase in the incidence of acute lymphoblastic leukaemia (14.6-39.2/million, AAPC: 1.25%). Kaplan-Meier analysis showed a significant improvement in overall survival over the study period. Starting from 25% of cases surviving 5 years in the 70s; the overall 5-year survival reached 80% by 2010. Survival differences were observed with sex, leukaemia type and age at diagnosis. A reverse association was found in the survival probability of leukaemia by degree of deprivation. The Cox proportional hazards model verified a significant reverse association with deprivation [hazard ratio=1.08 (1.04-1.12)]. This is the first nationwide study to confirm the prognostic role of deprivation on the basis of a large cohort of patients with childhood leukaemia during a 45-year period. To maintain further improvement in treatment results, it is important to detect inequalities. Our results showed that deprivation may also be important in the survival of leukaemia. LA - English DB - MTMT ER - TY - JOUR AU - Garami, Miklós AU - Schuler, Dezső AU - Jakab, Zsuzsanna TI - Az Országos Gyermektumor Regiszter jelentősége a gyermekonkológiai ellátásban. JF - ORVOSI HETILAP J2 - ORV HETIL VL - 155 PY - 2014 IS - 19 SP - 732 EP - 739 PG - 8 SN - 0030-6002 DO - 10.1556/OH.2014.29918 UR - https://m2.mtmt.hu/api/publication/2590592 ID - 2590592 N1 - Cited By :5 Export Date: 23 February 2024 CODEN: ORHEA AB - National Childhood Cancer Registry has been operated since 1971 by the Hungarian Paediatric Oncology Network. This Registry collects data on epidemiology, treatment modalities and effectiveness, as well as late follow-up of childhood cancers. An internet-based paediatric cancer registration and communication system for the Hungarian Paediatric Oncology Network has been introduced in April, 2010. The National Childhood Cancer Registry contains data of all paediatric cancer patients (0-18 yrs) who have insurance covered by the Hungarian Social Security Card. Creation (1971) and operation of the National Childhood Cancer Registry have been very important steps in the field of childhood oncology to evaluate the efficiency of paediatric oncology treatments as well as maximize return on medical investment. Orv. Hetil., 2014, 155(19), 732-739. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gatta, G AU - Botta, L AU - Rossi, S AU - Aareleid, T AU - Bielska-Lasota, M AU - Clavel, J AU - Dimitrova, N AU - Jakab, Zsuzsanna AU - Kaatsch, P AU - Lacour, B AU - Mallone, S AU - Marcos-Gragera, R AU - Minicozzi, P AU - Sanchez-Perez, MJ AU - Sant, M AU - Santaquilani, M AU - Stiller, C AU - Tavilla, A AU - Trama, A AU - Visser, O AU - Peris-Bonet, R AU - EUROCARE, Working Group TI - Childhood cancer survival in Europe 1999-2007: results of EUROCARE-5 - a population-based study JF - LANCET ONCOLOGY J2 - LANCET ONCOL VL - 15 PY - 2014 IS - 1 SP - 35 EP - 47 PG - 13 SN - 1470-2045 DO - 10.1016/S1470-2045(13)70548-5 UR - https://m2.mtmt.hu/api/publication/2538727 ID - 2538727 N1 - Erratum in Lancet Oncol. 2014 Feb;15(2):e52. AB - BACKGROUND: Survival and cure rates for childhood cancers in Europe have greatly improved over the past 40 years and are mostly good, although not in all European countries. The EUROCARE-5 survival study estimates survival of children diagnosed with cancer between 2000 and 2007, assesses whether survival differences among European countries have changed, and investigates changes from 1999 to 2007. METHODS: We analysed survival data for 157,499 children (age 0-14 years) diagnosed between Jan 1, 1978 and Dec 31, 2007. They came from 74 population-based cancer registries in 29 countries. We calculated observed, country-weighted 1-year, 3-year, and 5-year survival for major cancers and all cancers combined. For comparison between countries, we used the corrected group prognosis method to provide survival probabilities adjusted for multiple confounders (sex, age, period of diagnosis, and, for all cancers combined without CNS cancers, casemix). Age-adjusted survival differences by area and calendar period were calculated with period analysis and were given for all cancers combined and the major cancers. FINDINGS: We analysed 59,579 cases. For all cancers combined for children diagnosed in 2000-07, 1-year survival was 90.6% (95% CI 90.2-90.9), 3-year survival was 81.0 % (95% CI 80.5-81.4), and 5-year survival was 77.9% (95% CI 77.4-78.3). For all cancers combined, 5-year survival rose from 76.1% (74.4-77.7) for 1999-2001, to 79.1% (77.3-80.7) for 2005-07 (hazard ratio 0.973, 95% CI 0.965-0.982, p<0.0001). The greatest improvements were in eastern Europe, where 5-year survival rose from 65.2% (95% CI 63.1-67.3) in 1999-2001, to 70.2% (67.9-72.3) in 2005-07. Europe-wide average yearly change in mortality (hazard ratio) was 0.939 (95% CI 0.919-0.960) for acute lymphoid leukaemia, 0.959 (0.933-0.986) for acute myeloid leukaemia, and 0.940 (0.897-0.984) for non-Hodgkin lymphoma. Mortality for all of Europe did not change significantly for Hodgkin's lymphoma, Burkitt's lymphoma, CNS tumours, neuroblastoma, Wilms' tumour, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. Disparities for 5-year survival persisted between countries and regions, ranging from 70% to 82% (for 2005-07). INTERPRETATION: Several reasons might explain persisting inequalities. The lack of health-care resources is probably most important, especially in some eastern European countries with limited drug supply, lack of specialised centres with multidisciplinary teams, delayed diagnosis and treatment, poor management of treatment, and drug toxicity. In the short term, cross-border care and collaborative programmes could help to narrow the survival gaps in Europe. FUNDING: Italian Ministry of Health, European Commission, Compagnia di San Paolo Foundation. LA - English DB - MTMT ER - TY - JOUR AU - Gatta, Gemma AU - Botta, Laura TI - Childhood cancer survival in Europe: action is needed JF - EPIDEMIOLOGIA E PREVENZIONE J2 - EPIDEMIOL PREV VL - 37 PY - 2013 IS - 6 SP - 363 EP - 366 PG - 4 SN - 1120-9763 UR - https://m2.mtmt.hu/api/publication/24837816 ID - 24837816 LA - Italian DB - MTMT ER - TY - JOUR AU - Schuler, Dezső TI - A gyermekonkológia helyzete Magyarországon JF - ORVOSI HETILAP J2 - ORV HETIL VL - 153 PY - 2012 IS - 21 SP - 803 EP - 810 PG - 8 SN - 0030-6002 DO - 10.1556/OH.2012.29380 UR - https://m2.mtmt.hu/api/publication/2022238 ID - 2022238 N1 - TT: Paediatric oncology in Hungary Megjegyzés-22641308 TT: Paediatric oncology in Hungary AB - The significance of paediatric oncology is increasing due to its increasing incidence and its leading role among the causes of mortality in children. The epidemiology, prophylaxis and therapy of paediatric malignancies in Hungary are discussed surveying the results and the most important tasks in the future. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Garami, Miklós AU - Bognár, László AU - Hauser, Péter AU - Fekete, György AU - Schuler, Dezső TI - The Hungarian experience. Thirty-five years of progress in the field of pediatric oncology TS - Thirty-five years of progress in the field of pediatric oncology JF - MEDICAL DATA J2 - MED DATA VL - 3 PY - 2011 IS - 2 SP - 159 EP - 162 PG - 4 SN - 1821-1585 UR - https://m2.mtmt.hu/api/publication/2039286 ID - 2039286 LA - English DB - MTMT ER - TY - JOUR AU - Oláh, Éva AU - Balogh, Erzsébet AU - Pajor, László AU - Jakab, Zsuzsanna ED - Kovács, Gábor / Collaborator ED - Rényi, Imre / Collaborator ED - Békési, A / Collaborator ED - Kiss, Cs / Collaborator ED - Kajtar, P / Collaborator ED - Bartyik, Katalin / Collaborator ED - Nagy, K / Collaborator ED - Masat, P / Collaborator TI - Ten-year experiences on initial genetic examination in childhood acute lymphoblastic leukaemia in Hungary (1993-2002). Technical approaches and clinical implementation JF - PATHOLOGY AND ONCOLOGY RESEARCH J2 - PATHOL ONCOL RES VL - 17 PY - 2011 IS - 1 SP - 81 EP - 90 PG - 10 SN - 1219-4956 DO - 10.1007/s12253-010-9286-2 UR - https://m2.mtmt.hu/api/publication/1496511 ID - 1496511 AB - A nationwide study was started in 1993 to provide genetic diagnosis for all newly diagnosed childhood ALL cases in Hungary using cytogenetic examination, DNA-index determination, FISH (aneuploidy, ABL/BCR, TEL/AML1) and molecular genetic tests (ABL/BCR, MLL/AF4, TEL/AML1). Aim of the study was to assess the usefulness of different genetic methods, to study the frequency of various aberrations and their prognostic significance. Results were synthesized for genetic subgrouping of patients. To assess the prognostic value of genetic aberrations overall and event-free survival of genetic subgroups were compared using Kaplan-Meier method. Prognostic role of aberrations was investigated by multivariate analysis (Cox's regression) as well in comparison with other factors (age, sex, major congenital abnormalities, initial WBC, therapy, immunophenotype). Five hundred eighty-eight ALL cases were diagnosed between 1993-2002. Cytogenetic examination was performed in 537 (91%) (success rate 73%), DNA-index in 265 (45%), FISH in 74 (13%), TEL/AML1 RT-PCR in 219 (37%) cases producing genetic diagnosis in 457 patients (78%). Proportion of subgroups with good prognosis in prae-B-cell ALL was lower than expected: hyperdiploidB 18% (73/400), TEL/AML1+ 9% (36/400). Univariate analysis showed significantly better 5-year EFS in TEL/AML1+ (82%) and hyperdiploidB cases (78%) than in tetraploid (44%) or pseudodiploid (52%) subgroups. By multivariate analysis main negative prognostic factors were: congenital abnormalities, high WBC, delay in therapy, specific translocations. CONCLUSION: Complementary use of each of genetic methods used is necessary for reliable genetic diagnosis according to the algorithm presented. Specific genetic alterations proved to be of prognostic significance. LA - English DB - MTMT ER - TY - JOUR AU - Bognár, M AU - Ponyi, Andrea AU - Hauser, Péter AU - Müller, Judit AU - Constantin, Tamás AU - Jakab, Zsuzsanna AU - Schuler, Dezső AU - Garami, Miklós TI - Improper Supplementation Habits of Folic Acid Intake by Hungarian Pregnant Women. Improper Recommendations TS - Improper Recommendations JF - JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION J2 - J AM COLL NUTR VL - 27 PY - 2008 IS - 4 SP - 499 EP - 504 PG - 6 SN - 0731-5724 UR - https://m2.mtmt.hu/api/publication/1166498 ID - 1166498 AB - Background: Neural tube defects (NTDs) are some of the most common congenital anomalies. Proper folic acid supplementation is a dominant risk factor, which has been shown to decrease the incidence of NTDs. In Canada, the incidence of neuroblastoma has presented a considerable decrease of 60% as a result of enrichment cereal grain flours with synthetic folic acid. The aim of this study was to investigate the effect of folic acid intake by pregnant women on the incidence of NTDs and neuroblastoma. Methods: Regular folic acid intake has been recommended to pregnant women in Hungary since the eighties of the last century by health visitors eventually raking effect as an official protocol which had been released in 1997. During 2001, 2002 and 2003. folic acid intake habits of pregnant women were evaluated by health visitors, proving to be successful in collecting data front 95.06% of the pregnant women. The incidence of NTDs has been registered by the Hungarian National Centre of Epidemiology, Department of Human Genetics and Teratology. The Pediatric Cancer Registry provided the incidence of neuroblastoma in children. Results: Consistent findings revealed a regular intake of supplementary folic acid products by 68.71% of the pregnant women. Out of these. 93.13% of pregnant women who were taking folic acid, started the supplementation after their 7 weeks of pregnancies, a time designated as the completion period of the development of the neural tube. The dose of folic acid supplementation was evaluated as less than 5 mg/day in 84.75% of the pregnant women. In Hungary, the incidence of NTDs has remained constant, while the incidence of neuroblastoma has shown constant slight increase in spite of the introduction of folic acid supplementation in 1997. Conclusions: Based on our experience, folic acid supplementation was initiated after the recognition of pregnancy and its application in a dose of lower than 5 mg/day neither decreased the incidence of NTDs nor did it have an effect on the neuroblastoma incidence. It is implicated that proper folic acid supplementation, which is started front the conception. can be achieved only with the enrichment of cereal grain flours. LA - English DB - MTMT ER - TY - JOUR AU - Nyári, Tibor András AU - Kajtár, Pál AU - Parker, L ED - Edina, Magyarosy / Collaborator ED - Imre, Rényi / Collaborator ED - Kovács, Gábor / Collaborator ED - Garami, Miklós / Collaborator ED - Dezso, Schuler / Collaborator ED - Csongor, Kiss / Collaborator ED - Bartyik, Katalin / Collaborator ED - Ilona, Galántai / Collaborator ED - György, Péter / Collaborator ED - Anikó, Marosi / Collaborator ED - Kálmán, Nagy / Collaborator ED - Péter, Masát / Collaborator ED - Imre, Szalók / Collaborator ED - Krisztina, Milei / Collaborator ED - A, Békési / Collaborator TI - Neuroblastoma in Hungary JF - EUROPEAN JOURNAL OF CANCER J2 - EUR J CANCER VL - 42 PY - 2006 IS - 14 SP - 2350 EP - 2354 PG - 5 SN - 0959-8049 DO - 10.1016/j.ejca.2005.12.029 UR - https://m2.mtmt.hu/api/publication/1109802 ID - 1109802 N1 - Export Date: 27 January 2024; CODEN: EJCAE LA - English DB - MTMT ER - TY - JOUR AU - Török, Szabolcs János AU - Borgulya, Gábor AU - Lobmayer, Péter AU - Jakab, Zsuzsanna AU - Schuler, Dezső AU - Fekete, György TI - Childhood leukaemia incidence in Hungary, 1973-2002. Interpolation model for analysing the possible effects of the Chernobyl accident JF - EUROPEAN JOURNAL OF EPIDEMIOLOGY J2 - EUR J EPIDEMIOL VL - 20 PY - 2005 IS - 11 SP - 899 EP - 906 PG - 8 SN - 0393-2990 DO - 10.1007/s10654-005-2340-9 UR - https://m2.mtmt.hu/api/publication/1205457 ID - 1205457 LA - English DB - MTMT ER - TY - JOUR AU - Wagner, H TI - Applicability of the Hungarian experience to PODC JF - MEDICAL AND PEDIATRIC ONCOLOGY J2 - MED PEDIATR ONCOL VL - 32 PY - 1999 IS - 1 SP - 70 EP - 70 PG - 1 SN - 0098-1532 DO - 10.1002/(SICI)1096-911X(199901)32:1<70::AID-MPO17>3.0.CO;2-5 UR - https://m2.mtmt.hu/api/publication/22682232 ID - 22682232 LA - English DB - MTMT ER -