@article{MTMT:34745401, title = {International study of childhood leukemia in residences near electrical transformer rooms}, url = {https://m2.mtmt.hu/api/publication/34745401}, author = {Crespi, C.M. and Sudan, M. and Juutilainen, J. and Roivainen, P. and Hareuveny, R. and Huss, A. and Kandel, S. and Karim-Kos, H.E. and Thuróczy, G. and Jakab, Zsuzsanna and Spycher, B.D. and Flueckiger, B. and Vermeulen, R. and Vergara, X. and Kheifets, L.}, doi = {10.1016/j.envres.2024.118459}, journal-iso = {ENVIRON RES}, journal = {ENVIRONMENTAL RESEARCH}, volume = {249}, unique-id = {34745401}, issn = {0013-9351}, year = {2024}, eissn = {1096-0953}, orcid-numbers = {Jakab, Zsuzsanna/0000-0002-5410-1187} } @article{MTMT:35057757, title = {Nemzeti Gyermekonkológiai Regiszter}, url = {https://m2.mtmt.hu/api/publication/35057757}, author = {Garami, Miklós and Jakab, Zsuzsanna}, doi = {10.1556/650.2024.33061}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {165}, unique-id = {35057757}, issn = {0030-6002}, year = {2024}, eissn = {1788-6120}, pages = {933-943}, orcid-numbers = {Garami, Miklós/0000-0003-4298-2746; Jakab, Zsuzsanna/0000-0002-5410-1187} } @article{MTMT:32769159, title = {Clinical Course of COVID-19 Disease in Children Treated With Neoplastic Diseases in Hungary}, url = {https://m2.mtmt.hu/api/publication/32769159}, author = {Müller, Judit and Szűcs-Farkas, Dóra and Szegedi, István and Csóka, Monika and Garami, Miklós and Tiszlavicz, Lilla Györgyi and Hauser, Péter and Kriván, Gergely and Csanádi, Krisztina and Ottóffy, Gábor and Nagy, Béla and Kiss, Csongor and Kovács, Gábor}, doi = {10.3389/pore.2022.1610261}, journal-iso = {PATHOL ONCOL RES}, journal = {PATHOLOGY AND ONCOLOGY RESEARCH}, volume = {28}, unique-id = {32769159}, issn = {1219-4956}, abstract = {We report on children with cancer in Hungary suffering from COVID-19, surveying a 13-months-long period of time. We performed a retrospective clinical trial studying the medical documentation of children treated in seven centers of the Hungarian Pediatric Oncology-Hematology Group. About 10% of children admitted to tertiary hemato-oncological centers for anti-neoplastic treatment or diagnosis for de novo malignancies were positive for SARS-CoV-2 infection. Nearly two-thirds of the infected patients were asymptomatic or had only mild symptoms but showed seropositivity by 1-4.5 months after positive PCR. One third of the SARS-CoV-2-positive children were hospitalized due to symptomatic COVID-19. Five children required antiviral treatment with remdesivir. One child was referred to the intensive care unit, requiring intubation and mechanical ventilation. Delay in the scheduled anti-cancer treatment did not exceed 2 weeks in the majority (89%) of cases. There was only one patient requiring treatment deferral longer than a month. There was no COVID-19-related death in patients under 18 years of age, and nor was multisystem inflammatory syndrome diagnosed. In conclusion, SARS-CoV-2 infection did not represent an untoward risk factor among children with cancer in Hungary.}, keywords = {COVID-19; SARS-CoV-2; pediatric malignancy; chemotherapy delay; SARS-CoV-2S antibodies}, year = {2022}, eissn = {1532-2807}, orcid-numbers = {Müller, Judit/0000-0002-0488-7759; Csóka, Monika/0000-0003-4202-891X; Garami, Miklós/0000-0003-4298-2746; Hauser, Péter/0000-0002-8307-8975; Csanádi, Krisztina/0009-0001-6277-0137; Kovács, Gábor/0000-0001-9924-1645} } @article{MTMT:31701237, title = {Childhood cancer mortality trends in Europe, 1990-2017, with focus on geographic differences}, url = {https://m2.mtmt.hu/api/publication/31701237}, author = {Bertuccio, Paola and Alicandro, Gianfranco and Malvezzi, Matteo and Carioli, Greta and Boffetta, Paolo and Levi, Fabio and La Vecchia, Carlo and Negri, Eva}, doi = {10.1016/j.canep.2020.101768}, journal-iso = {CANCER EPIDEMIOL}, journal = {CANCER EPIDEMIOLOGY}, volume = {67}, unique-id = {31701237}, issn = {1877-7821}, abstract = {Aim: To monitor trends in childhood cancer mortality in Europe.Methods: We calculated age-standardized mortality rates per 100,000 children (age 0-14 years) from 1990 to the last available calendar year, for all neoplasms and six main cancers in childhood, in selected European countries and geographic areas, plus the European Union (EU), using data from the World Health Organization database. We carried out a joinpoint regression analysis of mortality trends for all neoplasms, leukaemia and tumours of the nervous system.Results of the joinpoint regression were summarized through annual percent change (APC) for each identified linear segment, and weighted average APC (AAPC) over the whole period.Results: From 1990 to 2015, childhood total cancer mortality rates dropped by 2.8% per year in the EU, to reach 2.6/100,000 in the latest available calendar years. The greatest declines were in central-eastern countries (AAPCs -3% to -4%). Recent rates ranged between 1.7 and 4.3 deaths/100,000, with the highest values in central-eastern Europe. Leukaemia mortality rates in the EU decreased from 1.6 to 0.6/100,000 in the latest calendar years (AAPC -4%). The deepest declines were registered in central-eastern countries, though they still showed the highest rates (0.9). The lowest leukaemia mortality rates were in northern-western Europe (0.5/100,000), but also in the Czech Republic and Poland. Southern European countries showed comparatively high rates (0.8). Nervous system tumours showed relatively modest falls (AAPC: -1.7% in the EU).Conclusions: Childhood cancer mortality continued to decline steady in Europe, though geographic differences persist. Further efforts are required to fill the gap, by promoting widespread and rational adoption of currently available treatment protocols.}, keywords = {Europe; CANCER; MORTALITY; childhood; TRENDS}, year = {2020}, eissn = {1877-783X} } @article{MTMT:31337068, title = {Late mortality in survivors of childhood cancer in Hungary}, url = {https://m2.mtmt.hu/api/publication/31337068}, author = {Jakab, Zsuzsanna and Garami, Miklós and Bartyik, Katalin and Csóka, Monika and Erdélyi, Dániel and Hauser, Péter and Juhász, Attila and Kelemen, Agnes and Kriván, Gergely and Masat, Peter and Müller, Judit and Nagy, Csilla and Peter, Gyorgy and Rényi, Imre and Szegedi, István and Vojcek, Ágnes and Zombori, Marianna and Bardi, Edit and Kovács, Gábor}, doi = {10.1038/s41598-020-67444-1}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {10}, unique-id = {31337068}, issn = {2045-2322}, year = {2020}, eissn = {2045-2322}, orcid-numbers = {Jakab, Zsuzsanna/0000-0002-5410-1187; Garami, Miklós/0000-0003-4298-2746; Csóka, Monika/0000-0003-4202-891X; Erdélyi, Dániel/0000-0001-5544-9209; Hauser, Péter/0000-0002-8307-8975; Müller, Judit/0000-0002-0488-7759; Rényi, Imre/0000-0002-5998-0627; Kovács, Gábor/0000-0001-9924-1645} } @article{MTMT:3250870, title = {Trends and territorial inequalities of incidence and survival of childhood leukaemia and their relations to socioeconomic status in Hungary, 1971-2015}, url = {https://m2.mtmt.hu/api/publication/3250870}, author = {Jakab, Zsuzsanna and Juhász, Attila and Nagy, Csilla and Schuler, Dezső and Garami, Miklós}, doi = {10.1097/CEJ.0000000000000386}, journal-iso = {EUR J CANCER PREV}, journal = {EUROPEAN JOURNAL OF CANCER PREVENTION}, volume = {26}, unique-id = {3250870}, issn = {0959-8278}, abstract = {The Hungarian Childhood Cancer Registry, a population-based national registry of the Hungarian Paediatric Haemato-Oncology Network founded in 1971, monitors the incidence and mortality of childhood cancer. Our aims were to carry out a longitudinal study to investigate the trends and spatial inequalities of incidence and survival of leukaemia, and the association between survival and deprivation in Hungary. All cases of childhood leukaemia and myelodysplasia were analysed (3157 cases, 1971-2015, age: 0-14 years). Time trends and the annual percentage change in direct standardized incidence and mortality were assessed. Survival and association with deprivation were assessed using the Kaplan-Meier method and Cox regression. Incidence rates of leukaemia (23.5-56.0/million) increased with an average annual percent change (AAPC) of 1%, determined by an increase in the incidence of acute lymphoblastic leukaemia (14.6-39.2/million, AAPC: 1.25%). Kaplan-Meier analysis showed a significant improvement in overall survival over the study period. Starting from 25% of cases surviving 5 years in the 70s; the overall 5-year survival reached 80% by 2010. Survival differences were observed with sex, leukaemia type and age at diagnosis. A reverse association was found in the survival probability of leukaemia by degree of deprivation. The Cox proportional hazards model verified a significant reverse association with deprivation [hazard ratio=1.08 (1.04-1.12)]. This is the first nationwide study to confirm the prognostic role of deprivation on the basis of a large cohort of patients with childhood leukaemia during a 45-year period. To maintain further improvement in treatment results, it is important to detect inequalities. Our results showed that deprivation may also be important in the survival of leukaemia.}, year = {2017}, eissn = {1473-5709}, pages = {S183-S190}, orcid-numbers = {Jakab, Zsuzsanna/0000-0002-5410-1187; Schuler, Dezső/0000-0002-2953-3244; Garami, Miklós/0000-0003-4298-2746} } @article{MTMT:2590592, title = {Az Országos Gyermektumor Regiszter jelentősége a gyermekonkológiai ellátásban.}, url = {https://m2.mtmt.hu/api/publication/2590592}, author = {Garami, Miklós and Schuler, Dezső and Jakab, Zsuzsanna}, doi = {10.1556/OH.2014.29918}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {155}, unique-id = {2590592}, issn = {0030-6002}, abstract = {National Childhood Cancer Registry has been operated since 1971 by the Hungarian Paediatric Oncology Network. This Registry collects data on epidemiology, treatment modalities and effectiveness, as well as late follow-up of childhood cancers. An internet-based paediatric cancer registration and communication system for the Hungarian Paediatric Oncology Network has been introduced in April, 2010. The National Childhood Cancer Registry contains data of all paediatric cancer patients (0-18 yrs) who have insurance covered by the Hungarian Social Security Card. Creation (1971) and operation of the National Childhood Cancer Registry have been very important steps in the field of childhood oncology to evaluate the efficiency of paediatric oncology treatments as well as maximize return on medical investment. Orv. Hetil., 2014, 155(19), 732-739.}, year = {2014}, eissn = {1788-6120}, pages = {732-739}, orcid-numbers = {Garami, Miklós/0000-0003-4298-2746; Schuler, Dezső/0000-0002-2953-3244; Jakab, Zsuzsanna/0000-0002-5410-1187} } @article{MTMT:2538727, title = {Childhood cancer survival in Europe 1999-2007: results of EUROCARE-5 - a population-based study}, url = {https://m2.mtmt.hu/api/publication/2538727}, author = {Gatta, G and Botta, L and Rossi, S and Aareleid, T and Bielska-Lasota, M and Clavel, J and Dimitrova, N and Jakab, Zsuzsanna and Kaatsch, P and Lacour, B and Mallone, S and Marcos-Gragera, R and Minicozzi, P and Sanchez-Perez, MJ and Sant, M and Santaquilani, M and Stiller, C and Tavilla, A and Trama, A and Visser, O and Peris-Bonet, R and EUROCARE, Working Group}, doi = {10.1016/S1470-2045(13)70548-5}, journal-iso = {LANCET ONCOL}, journal = {LANCET ONCOLOGY}, volume = {15}, unique-id = {2538727}, issn = {1470-2045}, abstract = {BACKGROUND: Survival and cure rates for childhood cancers in Europe have greatly improved over the past 40 years and are mostly good, although not in all European countries. The EUROCARE-5 survival study estimates survival of children diagnosed with cancer between 2000 and 2007, assesses whether survival differences among European countries have changed, and investigates changes from 1999 to 2007. METHODS: We analysed survival data for 157,499 children (age 0-14 years) diagnosed between Jan 1, 1978 and Dec 31, 2007. They came from 74 population-based cancer registries in 29 countries. We calculated observed, country-weighted 1-year, 3-year, and 5-year survival for major cancers and all cancers combined. For comparison between countries, we used the corrected group prognosis method to provide survival probabilities adjusted for multiple confounders (sex, age, period of diagnosis, and, for all cancers combined without CNS cancers, casemix). Age-adjusted survival differences by area and calendar period were calculated with period analysis and were given for all cancers combined and the major cancers. FINDINGS: We analysed 59,579 cases. For all cancers combined for children diagnosed in 2000-07, 1-year survival was 90.6% (95% CI 90.2-90.9), 3-year survival was 81.0 % (95% CI 80.5-81.4), and 5-year survival was 77.9% (95% CI 77.4-78.3). For all cancers combined, 5-year survival rose from 76.1% (74.4-77.7) for 1999-2001, to 79.1% (77.3-80.7) for 2005-07 (hazard ratio 0.973, 95% CI 0.965-0.982, p<0.0001). The greatest improvements were in eastern Europe, where 5-year survival rose from 65.2% (95% CI 63.1-67.3) in 1999-2001, to 70.2% (67.9-72.3) in 2005-07. Europe-wide average yearly change in mortality (hazard ratio) was 0.939 (95% CI 0.919-0.960) for acute lymphoid leukaemia, 0.959 (0.933-0.986) for acute myeloid leukaemia, and 0.940 (0.897-0.984) for non-Hodgkin lymphoma. Mortality for all of Europe did not change significantly for Hodgkin's lymphoma, Burkitt's lymphoma, CNS tumours, neuroblastoma, Wilms' tumour, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. Disparities for 5-year survival persisted between countries and regions, ranging from 70% to 82% (for 2005-07). INTERPRETATION: Several reasons might explain persisting inequalities. The lack of health-care resources is probably most important, especially in some eastern European countries with limited drug supply, lack of specialised centres with multidisciplinary teams, delayed diagnosis and treatment, poor management of treatment, and drug toxicity. In the short term, cross-border care and collaborative programmes could help to narrow the survival gaps in Europe. FUNDING: Italian Ministry of Health, European Commission, Compagnia di San Paolo Foundation.}, year = {2014}, eissn = {1474-5488}, pages = {35-47}, orcid-numbers = {Jakab, Zsuzsanna/0000-0002-5410-1187} } @article{MTMT:24837816, title = {Childhood cancer survival in Europe: action is needed}, url = {https://m2.mtmt.hu/api/publication/24837816}, author = {Gatta, Gemma and Botta, Laura}, journal-iso = {EPIDEMIOL PREV}, journal = {EPIDEMIOLOGIA E PREVENZIONE}, volume = {37}, unique-id = {24837816}, issn = {1120-9763}, year = {2013}, eissn = {2385-1937}, pages = {363-366} } @article{MTMT:2022238, title = {A gyermekonkológia helyzete Magyarországon}, url = {https://m2.mtmt.hu/api/publication/2022238}, author = {Schuler, Dezső}, doi = {10.1556/OH.2012.29380}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {153}, unique-id = {2022238}, issn = {0030-6002}, abstract = {The significance of paediatric oncology is increasing due to its increasing incidence and its leading role among the causes of mortality in children. The epidemiology, prophylaxis and therapy of paediatric malignancies in Hungary are discussed surveying the results and the most important tasks in the future.}, keywords = {ARTICLE; human; Hungary; cancer epidemiology; cancer therapy; cancer mortality; CANCER INCIDENCE; childhood cancer; cancer prevention; therapy of cancer in children; prophylaxis of cancer in children; paediatric oncology; epidemiology of cancer in children}, year = {2012}, eissn = {1788-6120}, pages = {803-810}, orcid-numbers = {Schuler, Dezső/0000-0002-2953-3244} } @article{MTMT:2039286, title = {The Hungarian experience. Thirty-five years of progress in the field of pediatric oncology}, url = {https://m2.mtmt.hu/api/publication/2039286}, author = {Garami, Miklós and Bognár, László and Hauser, Péter and Fekete, György and Schuler, Dezső}, journal-iso = {MED DATA}, journal = {MEDICAL DATA}, volume = {3}, unique-id = {2039286}, issn = {1821-1585}, year = {2011}, pages = {159-162}, orcid-numbers = {Garami, Miklós/0000-0003-4298-2746; Hauser, Péter/0000-0002-8307-8975; Fekete, György/0000-0002-5312-2541; Schuler, Dezső/0000-0002-2953-3244} } @article{MTMT:1496511, title = {Ten-year experiences on initial genetic examination in childhood acute lymphoblastic leukaemia in Hungary (1993-2002). Technical approaches and clinical implementation}, url = {https://m2.mtmt.hu/api/publication/1496511}, author = {Oláh, Éva and Balogh, Erzsébet and Pajor, László and Jakab, Zsuzsanna}, doi = {10.1007/s12253-010-9286-2}, journal-iso = {PATHOL ONCOL RES}, journal = {PATHOLOGY AND ONCOLOGY RESEARCH}, volume = {17}, unique-id = {1496511}, issn = {1219-4956}, abstract = {A nationwide study was started in 1993 to provide genetic diagnosis for all newly diagnosed childhood ALL cases in Hungary using cytogenetic examination, DNA-index determination, FISH (aneuploidy, ABL/BCR, TEL/AML1) and molecular genetic tests (ABL/BCR, MLL/AF4, TEL/AML1). Aim of the study was to assess the usefulness of different genetic methods, to study the frequency of various aberrations and their prognostic significance. Results were synthesized for genetic subgrouping of patients. To assess the prognostic value of genetic aberrations overall and event-free survival of genetic subgroups were compared using Kaplan-Meier method. Prognostic role of aberrations was investigated by multivariate analysis (Cox's regression) as well in comparison with other factors (age, sex, major congenital abnormalities, initial WBC, therapy, immunophenotype). Five hundred eighty-eight ALL cases were diagnosed between 1993-2002. Cytogenetic examination was performed in 537 (91%) (success rate 73%), DNA-index in 265 (45%), FISH in 74 (13%), TEL/AML1 RT-PCR in 219 (37%) cases producing genetic diagnosis in 457 patients (78%). Proportion of subgroups with good prognosis in prae-B-cell ALL was lower than expected: hyperdiploidB 18% (73/400), TEL/AML1+ 9% (36/400). Univariate analysis showed significantly better 5-year EFS in TEL/AML1+ (82%) and hyperdiploidB cases (78%) than in tetraploid (44%) or pseudodiploid (52%) subgroups. By multivariate analysis main negative prognostic factors were: congenital abnormalities, high WBC, delay in therapy, specific translocations. CONCLUSION: Complementary use of each of genetic methods used is necessary for reliable genetic diagnosis according to the algorithm presented. Specific genetic alterations proved to be of prognostic significance.}, year = {2011}, eissn = {1532-2807}, pages = {81-90}, orcid-numbers = {Jakab, Zsuzsanna/0000-0002-5410-1187; Kovács, Gábor/0000-0001-9924-1645; Rényi, Imre/0000-0002-5998-0627} } @article{MTMT:1166498, title = {Improper Supplementation Habits of Folic Acid Intake by Hungarian Pregnant Women. Improper Recommendations}, url = {https://m2.mtmt.hu/api/publication/1166498}, author = {Bognár, M and Ponyi, Andrea and Hauser, Péter and Müller, Judit and Constantin, Tamás and Jakab, Zsuzsanna and Schuler, Dezső and Garami, Miklós}, journal-iso = {J AM COLL NUTR}, journal = {JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION}, volume = {27}, unique-id = {1166498}, issn = {0731-5724}, abstract = {Background: Neural tube defects (NTDs) are some of the most common congenital anomalies. Proper folic acid supplementation is a dominant risk factor, which has been shown to decrease the incidence of NTDs. In Canada, the incidence of neuroblastoma has presented a considerable decrease of 60% as a result of enrichment cereal grain flours with synthetic folic acid. The aim of this study was to investigate the effect of folic acid intake by pregnant women on the incidence of NTDs and neuroblastoma. Methods: Regular folic acid intake has been recommended to pregnant women in Hungary since the eighties of the last century by health visitors eventually raking effect as an official protocol which had been released in 1997. During 2001, 2002 and 2003. folic acid intake habits of pregnant women were evaluated by health visitors, proving to be successful in collecting data front 95.06% of the pregnant women. The incidence of NTDs has been registered by the Hungarian National Centre of Epidemiology, Department of Human Genetics and Teratology. The Pediatric Cancer Registry provided the incidence of neuroblastoma in children. Results: Consistent findings revealed a regular intake of supplementary folic acid products by 68.71% of the pregnant women. Out of these. 93.13% of pregnant women who were taking folic acid, started the supplementation after their 7 weeks of pregnancies, a time designated as the completion period of the development of the neural tube. The dose of folic acid supplementation was evaluated as less than 5 mg/day in 84.75% of the pregnant women. In Hungary, the incidence of NTDs has remained constant, while the incidence of neuroblastoma has shown constant slight increase in spite of the introduction of folic acid supplementation in 1997. Conclusions: Based on our experience, folic acid supplementation was initiated after the recognition of pregnancy and its application in a dose of lower than 5 mg/day neither decreased the incidence of NTDs nor did it have an effect on the neuroblastoma incidence. It is implicated that proper folic acid supplementation, which is started front the conception. can be achieved only with the enrichment of cereal grain flours.}, year = {2008}, eissn = {1541-1087}, pages = {499-504}, orcid-numbers = {Ponyi, Andrea/0000-0001-9518-3193; Hauser, Péter/0000-0002-8307-8975; Müller, Judit/0000-0002-0488-7759; Constantin, Tamás/0000-0002-0146-3045; Jakab, Zsuzsanna/0000-0002-5410-1187; Schuler, Dezső/0000-0002-2953-3244; Garami, Miklós/0000-0003-4298-2746} } @article{MTMT:1109802, title = {Neuroblastoma in Hungary}, url = {https://m2.mtmt.hu/api/publication/1109802}, author = {Nyári, Tibor András and Kajtár, Pál and Parker, L}, doi = {10.1016/j.ejca.2005.12.029}, journal-iso = {EUR J CANCER}, journal = {EUROPEAN JOURNAL OF CANCER}, volume = {42}, unique-id = {1109802}, issn = {0959-8049}, year = {2006}, eissn = {1879-0852}, pages = {2350-2354}, orcid-numbers = {Nyári, Tibor András/0000-0001-8900-6641; Kovács, Gábor/0000-0001-9924-1645; Garami, Miklós/0000-0003-4298-2746; Dezso, Schuler/0000-0003-4298-2746} } @article{MTMT:1205457, title = {Childhood leukaemia incidence in Hungary, 1973-2002. Interpolation model for analysing the possible effects of the Chernobyl accident}, url = {https://m2.mtmt.hu/api/publication/1205457}, author = {Török, Szabolcs János and Borgulya, Gábor and Lobmayer, Péter and Jakab, Zsuzsanna and Schuler, Dezső and Fekete, György}, doi = {10.1007/s10654-005-2340-9}, journal-iso = {EUR J EPIDEMIOL}, journal = {EUROPEAN JOURNAL OF EPIDEMIOLOGY}, volume = {20}, unique-id = {1205457}, issn = {0393-2990}, keywords = {exposure; Hungary; RADIATION; REGISTRY; Hormesis; MALIGNANCIES; THYROID-CANCER; INFANT LEUKEMIA; radiation risk; interpolation model; childhood leukaemia incidence; Chernobyl fallout}, year = {2005}, eissn = {1573-7284}, pages = {899-906}, orcid-numbers = {Török, Szabolcs János/0000-0003-4653-1707; Jakab, Zsuzsanna/0000-0002-5410-1187; Schuler, Dezső/0000-0002-2953-3244; Fekete, György/0000-0002-5312-2541} } @article{MTMT:22682232, title = {Applicability of the Hungarian experience to PODC}, url = {https://m2.mtmt.hu/api/publication/22682232}, author = {Wagner, H}, doi = {10.1002/(SICI)1096-911X(199901)32:1<70::AID-MPO17>3.0.CO;2-5}, journal-iso = {MED PEDIATR ONCOL}, journal = {MEDICAL AND PEDIATRIC ONCOLOGY}, volume = {32}, unique-id = {22682232}, issn = {0098-1532}, year = {1999}, eissn = {1096-911X}, pages = {70-70} }