@article{MTMT:34595592, title = {The influence of growth hormone deficiency on bone health and metabolism}, url = {https://m2.mtmt.hu/api/publication/34595592}, author = {Wydra, Arnika and Czajka-Oraniec, Izabella and Wydra, Jakub and Zgliczynski, Wojciech}, doi = {10.5114/reum/170244}, journal-iso = {REUMATOLOGIA-WARSZAWA}, journal = {REUMATOLOGIA-WARSZAWA}, volume = {61}, unique-id = {34595592}, issn = {0034-6233}, abstract = {Growth hormone (GH) is a key peptide hormone in the regulation of bone metabolism, through its systemic and paracrine action mediated directly as well as by insulin-like growth factor-1 (IGF-1). Growth hormone exerts pleiotropic effects leading to an increase in linear bone growth, accumulation of bone mineral content and preservation of peak bone mass. Furthermore, it influences protein, lipid, and carbohydrate metabolism. Growth hormone deficiency (GHD) causes a low bone turnover rate leading to reduced bone mineral density (BMD) and increased bone fragility. The results of GH insufficiency are the most pronounced among children as it negatively affects longitudinal bone growth, causing short stature and in ado-lescents, in whom it hinders the acquisition of peak bone mass. Most studies show that treatment with recombinant human growth hormone (rhGH) in GHD patients could improve BMD and decrease fracture risk.This review aims to summarize the pathophysiology, clinical picture and management of bone com-plications observed in GHD.}, keywords = {Bone; FRACTURES; growth hormone deficiency}, year = {2023}, eissn = {2084-9834}, pages = {239-247} } @article{MTMT:31444995, title = {Competitive and Coordinative Interactions between Body Parts Produce Adaptive Developmental Outcomes}, url = {https://m2.mtmt.hu/api/publication/31444995}, author = {Gawne, Richard and McKenna, Kenneth Z. and Levin, Michael}, doi = {10.1002/bies.201900245}, journal-iso = {BIOESSAYS}, journal = {BIOESSAYS}, volume = {42}, unique-id = {31444995}, issn = {0265-9247}, abstract = {Large-scale patterns of correlated growth in development are partially driven by competition for metabolic and informational resources. It is argued that competition between organs for limited resources is an important mesoscale morphogenetic mechanism that produces fitness-enhancing correlated growth. At the genetic level, the growth of individual characters appears independent, or "modular," because patterns of expression and transcription are often highly localized, mutations have trait-specific effects, and gene complexes can be co-opted as a unit to produce novel traits. However, body parts are known to interact over the course of ontogeny, and these reciprocal exchanges can be an important determinant of developmental outcomes. Genetic mechanisms underlie cell and tissue behaviors that allow organs to communicate with one another, but they also create evolutionarily adaptive competitive dynamics that are driven by physiological and biophysical processes. Advances in the understanding of competitive and closely related coordinative interactions across scales will complement existing research programs that emphasize the role of cellular mechanisms in morphogenesis. Study of the large-scale order produced by competitive dynamics promises to facilitate advances in basic evolutionary and developmental biology, as well as applied research in fields such as bioengineering and regenerative medicine that aim to regulate patterning outcomes.}, keywords = {MORPHOGENESIS; ORGANOGENESIS; cellular competition; character competition; character coordination}, year = {2020}, eissn = {1521-1878}, orcid-numbers = {Levin, Michael/0000-0001-7292-8084} } @{MTMT:30680213, title = {Thyroid Hormone and Bone}, url = {https://m2.mtmt.hu/api/publication/30680213}, author = {Lakatos, Péter and Bakos, Bence and Takács, István and Stern, PH}, booktitle = {Principles of Bone Biology}, doi = {10.1016/B978-0-12-814841-9.00038-5}, unique-id = {30680213}, year = {2020}, pages = {895-914}, orcid-numbers = {Lakatos, Péter/0000-0002-7652-3671; Bakos, Bence/0000-0003-2073-6536; Takács, István/0000-0002-7810-4833} } @article{MTMT:3408945, title = {Skeletal Effects of Thyroid Hormones}, url = {https://m2.mtmt.hu/api/publication/3408945}, author = {Bakos, Bence and Takács, István and Stern, P and Lakatos, Péter}, doi = {10.1007/s12018-018-9246-z}, journal-iso = {CLIN REV BONE MINER METABOL}, journal = {CLINICAL REVIEWS IN BONE AND MINERAL METABOLISM}, volume = {16}, unique-id = {3408945}, issn = {1534-8644}, abstract = {The importance of functional thyroid abnormalities can hardly be overstated as they affect over 5% of the population. Thyroid hormones exert a multitude of effects on the metabolism of both the developing and the adult skeleton. It is thus unsurprising that changes in thyroid function can have a variety of often severe skeletal consequences. In recent years, numerous advances were made in the understanding of this domain. These include for instance the mapping of different pathways mediating genomic and nongenomic actions of thyroid hormones in osteoblasts and osteoclasts, or the investigation of the direct role of thyrotropin in skeletal remodeling. New disease states such as RTH alpha were recently recognized, and the clinical significance of subclinical thyroid dysfunctions in bone pathology is also better understood. In this current paper, we review the influence of thyroid hormones and different forms of thyroid disorders on bone metabolism with a special focus on practical clinical considerations.}, keywords = {FRACTURE; hyperthyroidism; RECEPTOR-ALPHA; HYPOTHYROIDISM; osteoporosis; GROWTH-FACTOR-I; BONE-MINERAL DENSITY; SERUM-FREE CULTURE; ALKALINE-PHOSPHATASE ACTIVITY; OSTEOBLAST-LIKE CELLS; RAT LIMB BONES; L-THYROXINE TREATMENT; EUTHYROID POSTMENOPAUSAL WOMEN; THYROTROPIN-SUPPRESSIVE THERAPY}, year = {2018}, eissn = {1559-0119}, pages = {57-66}, orcid-numbers = {Bakos, Bence/0000-0003-2073-6536; Takács, István/0000-0002-7810-4833; Lakatos, Péter/0000-0002-7652-3671} } @{MTMT:30751754, title = {GH/IGF-I and bone}, url = {https://m2.mtmt.hu/api/publication/30751754}, author = {Frara, S. and Maffezzoni, F. and Doga, M. and Formenti, A.M. and Mazziotti, G. and Giustina, A.}, booktitle = {Multidisciplinary Approach to Osteoporosis}, doi = {10.1007/978-3-319-75110-8_6}, unique-id = {30751754}, year = {2018}, pages = {83-106} } @article{MTMT:27548658, title = {Sexual Dimorphism and the Origins of Human Spinal Health}, url = {https://m2.mtmt.hu/api/publication/27548658}, author = {Gilsanz, Vicente and Wren, Tishya A L and Ponrartana, Skorn and Mora, Stefano and Rosen, Clifford J}, doi = {10.1210/er.2017-00147}, journal-iso = {ENDOCR REV}, journal = {ENDOCRINE REVIEWS}, volume = {39}, unique-id = {27548658}, issn = {0163-769X}, year = {2018}, eissn = {1945-7189}, pages = {221-239} } @article{MTMT:26736359, title = {Focus on growth hormone deficiency and bone in adults}, url = {https://m2.mtmt.hu/api/publication/26736359}, author = {Tritos, Nicholas A}, doi = {10.1016/j.beem.2017.02.002}, journal-iso = {BEST PRACT RES CL EN}, journal = {BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM}, volume = {31}, unique-id = {26736359}, issn = {1521-690X}, year = {2017}, eissn = {1532-1908}, pages = {49-57} } @article{MTMT:25793852, title = {Role of Thyroid Hormones in Skeletal Development and Bone Maintenance}, url = {https://m2.mtmt.hu/api/publication/25793852}, author = {Bassett, J H Duncan and Williams, Graham R}, doi = {10.1210/er.2015-1106}, journal-iso = {ENDOCR REV}, journal = {ENDOCRINE REVIEWS}, volume = {37}, unique-id = {25793852}, issn = {0163-769X}, year = {2016}, eissn = {1945-7189}, pages = {135-187} } @article{MTMT:26197929, title = {Effects of Thyroxine (T4), 3,5,3'-triiodo-L-thyronine (T3) and their Metabolites on Osteoblast Differentiation}, url = {https://m2.mtmt.hu/api/publication/26197929}, author = {Cheng, Shaohong and Xing, Weirong and Pourteymoor, Sheila and Mohan, Subburaman}, doi = {10.1007/s00223-016-0159-x}, journal-iso = {CALCIFIED TISSUE INT}, journal = {CALCIFIED TISSUE INTERNATIONAL}, volume = {99}, unique-id = {26197929}, issn = {0171-967X}, year = {2016}, eissn = {1432-0827}, pages = {435-442} } @article{MTMT:26197930, title = {Skeletal effects of growth hormone and insulin-like growth factor-I therapy}, url = {https://m2.mtmt.hu/api/publication/26197930}, author = {Lindsey, Richard C and Mohan, Subburaman}, doi = {10.1016/j.mce.2015.09.017}, journal-iso = {MOL CELL ENDOCRINOL}, journal = {MOLECULAR AND CELLULAR ENDOCRINOLOGY}, volume = {432}, unique-id = {26197930}, issn = {0303-7207}, year = {2016}, eissn = {1872-8057}, pages = {54-65} } @article{MTMT:26373749, title = {Implications of exercise-induced adipo-myokines in bone metabolism}, url = {https://m2.mtmt.hu/api/publication/26373749}, author = {Lombardi, Giovanni and Sanchis-Gomar, Fabian and Perego, Silvia and Sansoni, Veronica and Banfi, Giuseppe}, doi = {10.1007/s12020-015-0834-0}, journal-iso = {ENDOCRINE}, journal = {ENDOCRINE}, volume = {54}, unique-id = {26373749}, issn = {1355-008X}, year = {2016}, eissn = {1559-0100}, pages = {284-305}, orcid-numbers = {Lombardi, Giovanni/0000-0002-8365-985X} } @article{MTMT:26040477, title = {Effects of Growth Hormone on Bone}, url = {https://m2.mtmt.hu/api/publication/26040477}, author = {Tritos, Nicholas A and Klibanski, Anne}, doi = {10.1016/bs.pmbts.2015.10.008}, journal-iso = {PROG MOL BIOL TRANSL SCI}, journal = {PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE}, volume = {138}, unique-id = {26040477}, issn = {1877-1173}, year = {2016}, eissn = {1878-0814}, pages = {193-211} } @article{MTMT:24822025, title = {IGF-I in grazing dairy ewes during late pregnancy and lactation and its correlation to biochemical markers of bone metabolism}, url = {https://m2.mtmt.hu/api/publication/24822025}, author = {Tucek, Zvonimir and Filipovic, Natalija and Masek, Tomislav and Stojevic, Zvonko and Prvanovic, Nikica and Mikulec, Zeljko}, journal-iso = {VET ARHIV}, journal = {VETERINARSKI ARHIV}, volume = {84}, unique-id = {24822025}, issn = {0372-5480}, year = {2014}, eissn = {1331-8055}, pages = {331-345} } @article{MTMT:24822026, title = {Role and Mechanisms of Actions of Thyroid Hormone on the Skeletal Development}, url = {https://m2.mtmt.hu/api/publication/24822026}, author = {Kim, Ha-Young and Mohan, Subburaman}, doi = {10.4248/BR201302004}, journal-iso = {BONE RES}, journal = {BONE RESEARCH}, volume = {1}, unique-id = {24822026}, issn = {2095-4700}, year = {2013}, eissn = {2095-6231}, pages = {146-161} } @{MTMT:24703423, title = {Osteo-Odyssey: A Memoir}, url = {https://m2.mtmt.hu/api/publication/24703423}, author = {Stern, PH}, booktitle = {Osteoporosis,1-2}, doi = {10.1016/B978-0-12-415853-5.00005-4}, publisher = {Elsevier Inc.}, unique-id = {24703423}, year = {2013}, pages = {71-93} } @article{MTMT:24822027, title = {Role of Insulin-like Growth Factor-1 in the Regulation of Skeletal Growth}, url = {https://m2.mtmt.hu/api/publication/24822027}, author = {Mohan, Subburaman and Kesavan, Chandrasekhar}, doi = {10.1007/s11914-012-0100-9}, journal-iso = {CURR OSTEOPOROS REP}, journal = {CURRENT OSTEOPOROSIS REPORTS}, volume = {10}, unique-id = {24822027}, issn = {1544-1873}, year = {2012}, eissn = {1544-2241}, pages = {178-186} } @article{MTMT:24822028, title = {Regulation of insulin-like growth factors and their binding proteins by thyroid stimulating hormone in human osteoblast-like (SaOS2) cells}, url = {https://m2.mtmt.hu/api/publication/24822028}, author = {Ramajayam, G and Vignesh, R C and Karthikeyan, S and Kumar, K Senthil and Karthikeyan, G D and Veni, S and Sridhar, M and Arunakaran, J and Aruldhas, M Michael and Srinivasan, N}, doi = {10.1007/s11010-012-1345-4}, journal-iso = {MOL CELL BIOCHEM}, journal = {MOLECULAR AND CELLULAR BIOCHEMISTRY}, volume = {368}, unique-id = {24822028}, issn = {0300-8177}, year = {2012}, eissn = {1573-4919}, pages = {77-88} } @{MTMT:24617177, title = {Thyroid and Thyroid Hormone: Normal Function, Diseases, Disorders, Emerging Therapeutics}, url = {https://m2.mtmt.hu/api/publication/24617177}, author = {Stern, Paula H}, booktitle = {Bone-Metabolic Functions and Modulators}, doi = {10.1007/978-1-4471-2745-1_4}, publisher = {Springer London, Ltd}, unique-id = {24617177}, year = {2012}, pages = {69-86} } @article{MTMT:31240334, title = {Effects of Recombinant Human Growth Hormone Replacement Therapy on Thyroid Function and Skeletal in Children}, url = {https://m2.mtmt.hu/api/publication/31240334}, author = {Li, Guimei and Wang, Qian}, journal-iso = {SHIYONG ERKE LINCHUANG ZAZHI / J APPL CLIN PEDIATRICS}, journal = {SHIYONG ERKE LINCHUANG ZAZHI / JOURNAL OF APPLIED CLINICAL PEDIATRICS}, volume = {26}, unique-id = {31240334}, issn = {1003-515X}, year = {2011}, pages = {1546-1548} } @article{MTMT:22431987, title = {Role of diabetes- and obesity-related protein in the regulation of osteoblast differentiation}, url = {https://m2.mtmt.hu/api/publication/22431987}, author = {Linares, GR and Xing, WR and Burghardt, H and Baumgartner, B and Chen, ST and Ricart, W and Fernandez-Real, JM and Zorzano, A and Mohan, S}, doi = {10.1152/ajpendo.00065.2011}, journal-iso = {AM J PHYSIOL ENDOC M}, journal = {AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM}, volume = {301}, unique-id = {22431987}, issn = {0193-1849}, year = {2011}, eissn = {1522-1555}, pages = {E40-E48} } @article{MTMT:22431989, title = {Cytokines and growth factors and thyroid hormone}, url = {https://m2.mtmt.hu/api/publication/22431989}, author = {Davis, PJ}, doi = {10.1097/MED.0b013e32830eba0e}, journal-iso = {CURR OPIN ENDOCRINOL DIABETES OBES}, journal = {CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY}, volume = {15}, unique-id = {22431989}, issn = {1752-296X}, year = {2008}, eissn = {1752-2978}, pages = {428-428} } @article{MTMT:22431988, title = {Growth hormone, insulin-like growth factors, and the skeleton}, url = {https://m2.mtmt.hu/api/publication/22431988}, author = {Giustina, A and Mazziotti, G and Canalis, E}, doi = {10.1210/er.2007-0036}, journal-iso = {ENDOCR REV}, journal = {ENDOCRINE REVIEWS}, volume = {29}, unique-id = {22431988}, issn = {0163-769X}, year = {2008}, eissn = {1945-7189}, pages = {535-559} } @{MTMT:27431944, title = {Thyroid Hormone and Bone}, url = {https://m2.mtmt.hu/api/publication/27431944}, author = {Stern, PH}, booktitle = {Principles of bone biology}, doi = {10.1016/B978-0-12-373884-4.00060-4}, publisher = {Elsevier Inc.}, volume = {1}, unique-id = {27431944}, year = {2008}, pages = {935-954} } @article{MTMT:23353668, title = {Advances in the Diagnosis and Treatment of Osteoporosis}, url = {https://m2.mtmt.hu/api/publication/23353668}, author = {Simmons, J and Zeitler, P and Steelman, J}, doi = {10.1016/j.yapd.2007.03.007}, journal-iso = {Advances in Pediatrics}, journal = {Advances in Pediatrics}, volume = {54}, unique-id = {23353668}, issn = {0065-3101}, year = {2007}, pages = {85-114} } @article{MTMT:21742729, title = {Effects of thyroid disorders on the bone. Auswirkungen von schilddrüsenfehlfunktionen auf den knochen}, url = {https://m2.mtmt.hu/api/publication/21742729}, author = {Mikosch, P}, doi = {10.1007/s10354-005-0222-0}, journal-iso = {WIEN MED WOCHENSCHR}, journal = {WIENER MEDIZINISCHE WOCHENSCHRIFT}, volume = {155}, unique-id = {21742729}, issn = {0043-5341}, year = {2005}, eissn = {1563-258X}, pages = {444-453} } @article{MTMT:22431990, title = {Contrasting skeletal phenotypes in mice with an identical mutation targeted to thyroid hormone receptor alpha 1 or beta}, url = {https://m2.mtmt.hu/api/publication/22431990}, author = {O'Shea, PJ and Bassett, JHD and Sriskantharajah, S and Ying, H and Cheng, SY and Williams, GR}, doi = {10.1210/me.2005-0224}, journal-iso = {MOL ENDOCRINOL}, journal = {MOLECULAR ENDOCRINOLOGY}, volume = {19}, unique-id = {22431990}, issn = {0888-8809}, year = {2005}, eissn = {1944-9917}, pages = {3045-3059} } @article{MTMT:22431993, title = {IGF-I and MAP kinase involvement in the stimulatory effects of LNCaP prostate cancer cell conditioned media on cell proliferation and protein synthesis in MC3T3-E1 osteoblastic cells}, url = {https://m2.mtmt.hu/api/publication/22431993}, author = {Bhattacharyya, RS and Stern, PH}, doi = {10.1002/jcb.10726}, journal-iso = {J CELL BIOCHEM}, journal = {JOURNAL OF CELLULAR BIOCHEMISTRY}, volume = {90}, unique-id = {22431993}, issn = {0730-2312}, year = {2003}, eissn = {1097-4644}, pages = {925-937} } @article{MTMT:1807246, title = {Pajzsmirigyhormonok és a csont : hasznos vagy káros?}, url = {https://m2.mtmt.hu/api/publication/1807246}, author = {Lakatos, Péter}, journal-iso = {ORVOSKÉPZÉS}, journal = {ORVOSKÉPZÉS}, volume = {78}, unique-id = {1807246}, issn = {0030-6037}, year = {2003}, pages = {11-16}, orcid-numbers = {Lakatos, Péter/0000-0002-7652-3671} } @article{MTMT:1802599, title = {Thyroid hormones: Beneficial or deleterious for bone?}, url = {https://m2.mtmt.hu/api/publication/1802599}, author = {Lakatos, Péter}, doi = {10.1007/s00223-002-0027-8}, journal-iso = {CALCIFIED TISSUE INT}, journal = {CALCIFIED TISSUE INTERNATIONAL}, volume = {73}, unique-id = {1802599}, issn = {0171-967X}, abstract = {The mechanism of action as well as the clinical effects of thyroid hormones on bone has been of interest for more than a century. With the appearance of new treatment modalities for thyroid function disorders, the accompanying alterations in bone metabolism appeared to be rare. However, the introduction of new diagnostic tools, such as osteodensitometry and biochemical bone markers, has changed our view since they were able to show smaller but important changes in bone mineral metabolism associated with thyroid function disorders. Now, we know that hyperthyroidism is associated with an increased life-time risk for fractures, even after achieving euthyroidism. This fact may play an important role in the higher mortality rate among previously hyperthyroid patients later in life. Subclinical hyperthyroidism may also affect bone density, however, its effect on fracture rate remains to be established. The lack of thyroid hormones will alter normal growth during childhood. Adult hypothyroid patients tend to exhibit higher than normal bone density. Despite rather increased bone quantity, hypothyroidism is accompanied with increased fracture risk before and after diagnosis. The effect of thyroid hormone treatment on bone tissue is somewhat controversial. Nevertheless, only patients with suppressed thyroid-stimulating hormone (TSH) appear to loose bone and have higher fracture incidence, whereas patients with a TSH level in the normal range seem to have similar bone mineral content and fracture rate as euthyroid subjects. In summary, most of thyroid function disorders may result in reduced bone density and/or increased fracture rate that should be taken into consideration at clinical evaluation.}, keywords = {Humans; MORTALITY; review; human; Incidence; disease association; risk assessment; correlation analysis; priority journal; nonhuman; FRACTURE; Bone Density; Bone metabolism; Densitometry; Bone and Bones; hyperthyroidism; HYPOTHYROIDISM; osteoporosis; diagnostic test; osteolysis; bone mineral; hormone action; hormone substitution; biochemical marker; thyroid disease; Thyrotropin; thyroid hormones; Thyroid hormone; thyrotropin blood level; bone growth; Bone loss; Bone fracture; Fractures, Bone; thyroid hormone blood level}, year = {2003}, eissn = {1432-0827}, pages = {205-209}, orcid-numbers = {Lakatos, Péter/0000-0002-7652-3671} } @article{MTMT:22431992, title = {The effects of triiodothyronine on human osteoblast-like cells metabolism and interactions with growth hormone}, url = {https://m2.mtmt.hu/api/publication/22431992}, author = {Pepene, CE and Seck, T and Pfeilschifter, J and Gozariu, L and Ziegler, R and Kasperk, CH}, doi = {10.1055/s-2003-39231}, journal-iso = {EXP CLIN ENDOCR DIAB}, journal = {EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES}, volume = {111}, unique-id = {22431992}, issn = {0947-7349}, year = {2003}, eissn = {1439-3646}, pages = {66-72} } @article{MTMT:22432223, title = {Molecular mechanisms of thyroid hormone effects on bone growth and function}, url = {https://m2.mtmt.hu/api/publication/22432223}, author = {Harvey, CB and O'Shea, PJ and Scott, AJ and Robson, H and Siebler, T and Shalet, SM and Smarut, J and Chassande, O and Williams, GR}, doi = {10.1006/mgme.2001.3268}, journal-iso = {MOL GENET METAB}, journal = {MOLECULAR GENETICS AND METABOLISM}, volume = {75}, unique-id = {22432223}, issn = {1096-7192}, year = {2002}, eissn = {1096-7206}, pages = {17-30} } @article{MTMT:21574047, title = {Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth}, url = {https://m2.mtmt.hu/api/publication/21574047}, author = {Robson, H and Siebler, T and Shalet, S M and Williams, G R}, doi = {10.1203/01.PDR.0000023494.70201.1C}, journal-iso = {PEDIATR RES}, journal = {PEDIATRIC RESEARCH}, volume = {52}, unique-id = {21574047}, issn = {0031-3998}, year = {2002}, eissn = {1530-0447}, pages = {137-147} } @article{MTMT:22431997, title = {Effect of advanced glycation endproducts on the secretion of insulin-like growth factor-I and its binding proteins: role in osteoblast development}, url = {https://m2.mtmt.hu/api/publication/22431997}, author = {McCarthy, AD and Etcheverry, SB and Cortizo, AM}, doi = {10.1007/s005920170007}, journal-iso = {ACTA DIABETOL}, journal = {ACTA DIABETOLOGICA}, volume = {38}, unique-id = {22431997}, issn = {0940-5429}, year = {2001}, eissn = {1432-5233}, pages = {113-122} } @article{MTMT:22431996, title = {Effects of triiodothyronine on the insulin-like growth factor system in primary human osteoblastic cells in vitro}, url = {https://m2.mtmt.hu/api/publication/22431996}, author = {Pepene, CE and Kasperk, CH and Pfeilschifter, J and Borcsok, I and Gozariu, L and Ziegler, R and Seck, T}, doi = {10.1016/S8756-3282(01)00607-X}, journal-iso = {BONE}, journal = {BONE}, volume = {29}, unique-id = {22431996}, issn = {8756-3282}, year = {2001}, eissn = {1873-2763}, pages = {540-546} } @article{MTMT:22431999, title = {Steroid hormone receptor expression and action in bone}, url = {https://m2.mtmt.hu/api/publication/22431999}, author = {Bland, R}, doi = {10.1042/CS19990252}, journal-iso = {CLIN SCI}, journal = {CLINICAL SCIENCE}, volume = {98}, unique-id = {22431999}, issn = {0143-5221}, year = {2000}, eissn = {1470-8736}, pages = {217-240} } @article{MTMT:22432001, title = {Insulin-like growth factor I production is essential for anabolic effects of thyroid hormone in osteoblasts}, url = {https://m2.mtmt.hu/api/publication/22432001}, author = {Huang, BK and Golden, LA and Tarjan, G and Madison, LD and Stern, PH}, doi = {10.1359/jbmr.2000.15.2.188}, journal-iso = {J BONE MINER RES}, journal = {JOURNAL OF BONE AND MINERAL RESEARCH}, volume = {15}, unique-id = {22432001}, issn = {0884-0431}, year = {2000}, eissn = {1523-4681}, pages = {188-197} } @article{MTMT:22431998, title = {Thyroid hormones and their effects: a new perspective}, url = {https://m2.mtmt.hu/api/publication/22431998}, author = {Hulbert, AJ}, doi = {10.1111/j.1469-185X.2000.tb00054.x}, journal-iso = {BIOL REV}, journal = {BIOLOGICAL REVIEWS}, volume = {75}, unique-id = {22431998}, issn = {1464-7931}, year = {2000}, eissn = {1469-185X}, pages = {519-631} } @article{MTMT:1335572, title = {Serum insulin-like growth factor-I, insulin-like growth factor binding proteins, and bone mineral content in hyperthyroidism.}, url = {https://m2.mtmt.hu/api/publication/1335572}, author = {Lakatos, Péter and Földes, János and Nagy, Zsolt and Takács, István and Speer, Gábor and Horváth, Csaba and Mohan, S and Baylink, DJ and Stern, PH}, doi = {10.1089/thy.2000.10.417}, journal-iso = {THYROID}, journal = {THYROID}, volume = {10}, unique-id = {1335572}, issn = {1050-7256}, abstract = {The mechanism by which thyroid hormones promote bone growth has not yet been elucidated. In vitro, thyroid hormones stimulate insulin-like growth factor-I (IGF-I) production by osteoblasts, which is important for the anabolic effects of the hormone on bone. To determine whether the IGF-I/IGF binding protein (IGFBP) profile is affected when thyroid hormone production is altered in vivo, we studied 36 women who had recently been diagnosed with hyperthyroidism (age: 29-67 years; 19 with Graves' disease, 17 with toxic nodular goiter) and 36 age-matched healthy women as controls. Serum IGF-I, and its binding proteins (IGFBP-3, IGFBP-4, and IGFBP-5), as well as bone mineral density (BMD) at the lumbar spine, femoral neck, and radius midshaft were measured before and 1 year after antithyroid (methimazole) treatment. Serum IGF-I levels were significantly increased in the hyperthyroid patients before treatment (214 +/- 18.2 ng/mL vs. 145 +/- 21.3 ng/mL; p < 0.05). There was no difference in IGF-I levels of patients with Graves' disease and toxic nodular goiter. Serum IGF-I concentrations returned to normal after treatment with methimazole. Serum IGFBP-3 and IGFBP-4 values were significantly elevated in the hyperthyroid group before treatment (3960 +/- 220 ng/mL and 749.7 +/- 53.1 ng/mL vs. 2701 +/- 180 ng/mL and 489.9 +/- 32.4 ng/mL; p < 0.05 and p < 0.01, respectively) and were reduced to those of controls after treatment. Serum IGFBP-5 of hyperthyroid subjects was not different from that of controls either before or after therapy. Serum free thyroxine showed a positive correlation with serum levels of IGF-I (r = 0.73, p < 0.05), IGFBP-3 (r = 0.59, p < 0.05), and IGFBP-4 (r = 0.67, p < 0.05) but not IGFBP-5. BMD at the radius midshaft was significantly lower in hyperthyroid patients at the start of the study and showed a positive correlation with serum IGF-I (r = 0.58; p < 0.001) and a negative correlation with IGFBP-4 (r = -0.61; p < 0.05). Radius BMD showed a 7.2% increase in the hyperthyroid group after 1 year of methimazole treatment, and the correlation between BMD and serum IGF-I disappeared. Our data indicate that thyroid hormones may influence the IGF-I/IGFBP system in vivo in hyperthyroidism. The anabolic effects of increased levels of IGF-I may be limited in hyperthyroidism due to the increases of inhibitory IGFBPs that can counteract the anabolic effects and contribute to the observed net bone loss.}, year = {2000}, eissn = {1557-9077}, pages = {417-423}, orcid-numbers = {Lakatos, Péter/0000-0002-7652-3671; Nagy, Zsolt/0000-0002-9648-1851; Takács, István/0000-0002-7810-4833; Horváth, Csaba/0000-0002-0490-7932} } @article{MTMT:22432002, title = {Growth hormone-regulated intracellular signaling in UMR 106 osteosarcoma cells}, url = {https://m2.mtmt.hu/api/publication/22432002}, author = {Morales, O and Lindgren, U and Haldosen, LA}, doi = {10.1359/jbmr.2000.15.11.2284}, journal-iso = {J BONE MINER RES}, journal = {JOURNAL OF BONE AND MINERAL RESEARCH}, volume = {15}, unique-id = {22432002}, issn = {0884-0431}, year = {2000}, eissn = {1523-4681}, pages = {2284-2290} } @article{MTMT:31240339, title = {Effects of basic fibroblastic growth factor (bFGF), transforming growth factor beta 1 (TGF-β1) and platelet-derived growth factor-BB (PDGF-BB) on human osteoblastic Sa-Os2 osteosarcoma cells and interactions with triiodothyronine}, url = {https://m2.mtmt.hu/api/publication/31240339}, author = {Pepene, C. and Gozariu, L. and Duncea, I. and Ziegler, R. and Kasperk, C.}, journal-iso = {Romanian Journal of Endocrinology}, journal = {Romanian Journal of Endocrinology}, volume = {38}, unique-id = {31240339}, issn = {1221-356X}, year = {2000}, pages = {3-9} } @article{MTMT:22432003, title = {Positive association between circulating free thyroxine and insulin-like growth factor I concentrations in euthyroid elderly individuals}, url = {https://m2.mtmt.hu/api/publication/22432003}, author = {Seck, T and Scheidt-Nave, C and Ziegler, R and Pfeilschifter, J}, doi = {10.1046/j.1365-2265.1998.00415.x}, journal-iso = {CLIN ENDOCRINOL}, journal = {CLINICAL ENDOCRINOLOGY}, volume = {48}, unique-id = {22432003}, issn = {0300-0664}, year = {1998}, eissn = {1365-2265}, pages = {361-366} } @article{MTMT:1802563, title = {Decreased serum IGF-I and dehydroepiandrosterone sulphate may be risk factors for the development of reduced bone mass in postmenopausal women with endogenous subclinical hyperthyroidism}, url = {https://m2.mtmt.hu/api/publication/1802563}, author = {Földes, János and Lakatos, Péter and Zsadányi, J and Horváth, Csaba}, doi = {10.1530/eje.0.1360277}, journal-iso = {EUR J ENDOCRINOL}, journal = {EUROPEAN JOURNAL OF ENDOCRINOLOGY}, volume = {136}, unique-id = {1802563}, issn = {0804-4643}, abstract = {Postmenopausal women with endogenous subclinical hyperthyroidism seem to have reduced bone mass, which does not correlate with serum thyroid hormone levels. Relative insufficiencies of IGF-I and dehydroepiandrosterone sulphate (DHEAS) might be additional risk factors for low bone density in these patients. We measured IGF-I, IGF-binding protein-3 (IGFBP-3) and DHEAS levels together with bone mineral density (BMD) of the femoral neck and lumbar spine in women with an autonomously functioning thyroid nodule. Sixty-three women were classified as subclinical hyperthyroid (31 pre- and 32 postmenopausal) and 39 as overt hyperthyroid (16 pre- and 23 postmenopausal) and results were compared with data obtained from 41 age-matched euthyroid healthy women. In premenopausal women BMD was reduced only in the overt hyperthyroid group, and only in the spine, to 92% (P < 0.05). Serum IGF-I as well as IGFBP-3 were increased in the manifest hyperthyroid group, to 157% (P < 0.001) and 129% (P < 0.05) respectively, whereas DHEAS levels did not change in either premenopausal patient group. In postmenopausal women BMD was significantly reduced both in the subclinical hyperthyroid group (spine to 90% and femoral neck to 88%; P < 0.05), as well as in the hyperthyroid group (spine to 78% and femoral neck to 86%; P < 0.01). In contrast to premenopausal women, serum IGF-I and IGFBP-3 did not change in the two groups who were postmenopausal and serum DHEAS levels were reduced to 58% (P < 0.001) in both postmenopausal groups with subclinical as well as overt hyperthyroidism. In the same two groups of patients, serum IGF-I and DHEAS levels correlated with BMD (femoral neck; both r = 0.50, P < 0.05). In conclusion, women with a solitary autonomous thyroid nodule with subclinical hyperthyroidism have reduced BMD only if they are postmenopausal. This is probably due to the effect of subtle increases in thyroid hormone production together with lack of oestrogen protection of the skeleton. But additional risk factors for the development of enhanced bone loss might be a state of relative IGF-I and DHEAS insufficiency in these patients as well as in postmenopausal women with overt hyperthyroidism.}, keywords = {Aged; Adult; Female; Middle Aged; Humans; ARTICLE; ESTRADIOL; human; Risk Factors; risk factor; priority journal; major clinical study; Bone Density; DEHYDROEPIANDROSTERONE SULFATE; BONE MASS; Insulin-Like Growth Factor I; hyperthyroidism; hormone blood level; Prasterone; Osteoporosis, Postmenopausal; thyroid hormones; intermedin; postmenopause osteoporosis; thyroid nodule}, year = {1997}, eissn = {1479-683X}, pages = {277-281}, orcid-numbers = {Lakatos, Péter/0000-0002-7652-3671; Horváth, Csaba/0000-0002-0490-7932} } @article{MTMT:1802122, title = {Serum interleukin-6 and bone metabolism in patients with thyroid function disorders}, url = {https://m2.mtmt.hu/api/publication/1802122}, author = {Lakatos, Péter and Földes, János and Horváth, Csaba and Kiss, L and Tatrai, A and Takács, István and Tarjan, G and Stern, P H}, doi = {10.1210/jcem.82.1.3641}, journal-iso = {J CLIN ENDOCR METAB}, journal = {JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM}, volume = {82}, unique-id = {1802122}, issn = {0021-972X}, abstract = {To determine the possible involvement of interleukin-6(IL-6) in the bone loss of hyperthyroidism, relationships between thyroid status, biochemical and densitometric parameters of bone metabolism, and IL-6 were studied in female subjects. Patients with hyperthyroidism caused by either toxic nodular goiter or Graves' disease had significantly higher serum IL-6 concentrations than normal controls. Within the control group, serum IL-6 was higher in postmenopausal than in premenopausal women, but this influence of menopausal status was not seen in the hyperthyroid patients. The production of IL-6 by blood mononuclear cells was higher in cells from the hyperthyroid women. Bone turnover was increased in the hyperthyroid patients based on serum osteocalcin and urinary deoxypyridinoline excretion, and the hyperthyroid group also had reduced radius bone mineral content (BMC). A subgroup of hyperthyroid patients who had the lowest BMC (values more than 1 SD below normal age-matched controls) also had serum IL-6 concentrations significantly greater than those of hyperthyroid patients showing less reduction of BMC. The correlations observed in this study support the possibility that IL-6 plays a role in mediating the bone loss that results from excess thyroid hormone.}, keywords = {Aged; Adult; Female; Middle Aged; Humans; ARTICLE; human; priority journal; clinical article; Bone Density; Bone metabolism; Bone and Bones; protein blood level; interleukin 6; hyperthyroidism; Leukocytes, Mononuclear; immunopathogenesis; amino acids; Graves disease; Interleukin-6; bone mineralization; bone atrophy; osteocalcin; Postmenopause; premenopause; Goiter, Nodular}, year = {1997}, eissn = {1945-7197}, pages = {78-81}, orcid-numbers = {Lakatos, Péter/0000-0002-7652-3671; Horváth, Csaba/0000-0002-0490-7932; Takács, István/0000-0002-7810-4833} } @article{MTMT:22432004, title = {Tissue-specific alterations in insulin-like growth factor-I concentrations in response to 3,3',5-triiodo-L-thyronine supplementation in the growth hormone receptor-deficient sex-linked dwarf chicken}, url = {https://m2.mtmt.hu/api/publication/22432004}, author = {VasilatosYounken, R and Dunnington, EA and Siegel, PB and McMurtry, JP}, doi = {10.1006/gcen.1996.6795}, journal-iso = {GEN COMP ENDOCR}, journal = {GENERAL AND COMPARATIVE ENDOCRINOLOGY}, volume = {105}, unique-id = {22432004}, issn = {0016-6480}, year = {1997}, eissn = {1095-6840}, pages = {31-39} } @article{MTMT:22432008, title = {Identification of IGF-I in the calvarial suture of young rats: Histochemical analysis of the cranial sagittal sutures in a hyperthyroid rat model}, url = {https://m2.mtmt.hu/api/publication/22432008}, author = {Akita, S and Hirano, A and Fujii, T}, doi = {10.1097/00006534-199601000-00001}, journal-iso = {PLAST RECONSTR SURG}, journal = {PLASTIC AND RECONSTRUCTIVE SURGERY}, volume = {97}, unique-id = {22432008}, issn = {0032-1052}, year = {1996}, eissn = {1529-4242}, pages = {1-12} } @article{MTMT:22432007, title = {Thyroid hormone and retinoic acid induce the synthesis of insulin-like growth factor-binding protein-4 in mouse osteoblastic cells}, url = {https://m2.mtmt.hu/api/publication/22432007}, author = {Glantschnig, H and Varga, F and Klaushofer, K}, doi = {10.1210/en.137.1.281}, journal-iso = {ENDOCRINOLOGY}, journal = {ENDOCRINOLOGY}, volume = {137}, unique-id = {22432007}, issn = {0013-7227}, year = {1996}, eissn = {1945-7170}, pages = {281-286} } @article{MTMT:22432227, title = {THE REGULATORY ROLE OF THYROID-HORMONES IN BONE CELL-GROWTH AND DIFFERENTIATION}, url = {https://m2.mtmt.hu/api/publication/22432227}, author = {KLAUSHOFER, K and VARGA, F and GLANTSCHNIG, H and FRATZLZELMAN, N and CZERWENKA, E and LEIS, HJ and KOLLER, K and PETERLIK, M}, journal-iso = {J NUTR}, journal = {JOURNAL OF NUTRITION}, volume = {125}, unique-id = {22432227}, issn = {0022-3166}, year = {1995}, eissn = {1541-6100}, pages = {S1996-S2003} } @article{MTMT:22432011, title = {ANABOLIC EFFECTS OF 3,3',5-TRIIODOTHYRONINE AND TRIIODOTHYROACETIC ACID IN CULTURED NEONATAL MOUSE PARIETAL BONES}, url = {https://m2.mtmt.hu/api/publication/22432011}, author = {KAWAGUCHI, H and PILBEAM, CC and RAISZ, LG}, doi = {10.1210/en.135.3.971}, journal-iso = {ENDOCRINOLOGY}, journal = {ENDOCRINOLOGY}, volume = {135}, unique-id = {22432011}, issn = {0013-7227}, year = {1994}, eissn = {1945-7170}, pages = {971-976} } @article{MTMT:22432010, title = {THYROID-HORMONES INCREASE INSULIN-LIKE GROWTH-FACTOR MESSENGER-RNA LEVELS IN THE CLONAL OSTEOBLASTIC CELL-LINE MC3T3-E1}, url = {https://m2.mtmt.hu/api/publication/22432010}, author = {VARGA, F and RUMPLER, M and KLAUSHOFER, K}, doi = {10.1016/0014-5793(94)00442-0}, journal-iso = {FEBS LETT}, journal = {FEBS LETTERS}, volume = {345}, unique-id = {22432010}, issn = {0014-5793}, year = {1994}, eissn = {1873-3468}, pages = {67-70} }