TY - JOUR AU - Cornblath, Eli J. J. AU - Lucas, Alfredo AU - Armstrong, Caren AU - Greenblatt, Adam S. S. AU - Stein, Joel M. M. AU - Hadar, Peter N. N. AU - Raghupathi, Ramya AU - Marsh, Eric AU - Litt, Brian AU - Davis, Kathryn A. A. AU - Conrad, Erin C. C. TI - Quantifying trial-by-trial variability during cortico-cortical evoked potential mapping of epileptogenic tissue JF - EPILEPSIA J2 - EPILEPSIA VL - 64 PY - 2023 IS - 4 SP - 1021 EP - 1034 PG - 14 SN - 0013-9580 DO - 10.1111/epi.17528 UR - https://m2.mtmt.hu/api/publication/33865809 ID - 33865809 N1 - Department of Neurology, Perelman School of Medicine, Philadelphia, PA, United States Department of Bioengineering, School of Engineering & Applied Science, Philadelphia, PA, United States Pediatric Epilepsy Program, Children's Hospital of Philadelphia, Philadelphia, PA, United States Department of Radiology, Perelman School of Medicine, Philadelphia, PA, United States Department of Pediatrics, Perelman School of Medicine, Philadelphia, PA, United States Export Date: 30 October 2023 CODEN: EPILA Correspondence Address: Cornblath, E.J.; Department of Neurology, United States; email: eli.cornblath@pennmedicine.upenn.edu AB - ObjectiveMeasuring cortico-cortical evoked potentials (CCEPs) is a promising tool for mapping epileptic networks, but it is not known how variability in brain state and stimulation technique might impact the use of CCEPs for epilepsy localization. We test the hypotheses that (1) CCEPs demonstrate systematic variability across trials and (2) CCEP amplitudes depend on the timing of stimulation with respect to endogenous, low-frequency oscillations. MethodsWe studied 11 patients who underwent CCEP mapping after stereo-electroencephalography electrode implantation for surgical evaluation of drug-resistant epilepsy. Evoked potentials were measured from all electrodes after each pulse of a 30 s, 1 Hz bipolar stimulation train. We quantified monotonic trends, phase dependence, and standard deviation (SD) of N1 (15-50 ms post-stimulation) and N2 (50-300 ms post-stimulation) amplitudes across the 30 stimulation trials for each patient. We used linear regression to quantify the relationship between measures of CCEP variability and the clinical seizure-onset zone (SOZ) or interictal spike rates. ResultsWe found that N1 and N2 waveforms exhibited both positive and negative monotonic trends in amplitude across trials. SOZ electrodes and electrodes with high interictal spike rates had lower N1 and N2 amplitudes with higher SD across trials. Monotonic trends of N1 and N2 amplitude were more positive when stimulating from an area with higher interictal spike rate. We also found intermittent synchronization of trial-level N1 amplitude with low-frequency phase in the hippocampus, which did not localize the SOZ. SignificanceThese findings suggest that standard approaches for CCEP mapping, which involve computing a trial-averaged response over a .2-1 Hz stimulation train, may be masking inter-trial variability that localizes to epileptogenic tissue. We also found that CCEP N1 amplitudes synchronize with ongoing low-frequency oscillations in the hippocampus. Further targeted experiments are needed to determine whether phase-locked stimulation could have a role in localizing epileptogenic tissue. LA - English DB - MTMT ER - TY - JOUR AU - Ezzyat, Youssef AU - Kragel, James E. AU - Solomon, Ethan A. AU - Lega, Bradley C. AU - Aronson, Joshua P. AU - Jobst, Barbara C. AU - Gross, Robert E. AU - Sperling, Michael R. AU - Worrell, Gregory A. AU - Sheth, Sameer A. AU - Wanda, Paul A. AU - Rizzuto, Daniel S. AU - Kahana, Michael J. TI - Functional and anatomical connectivity predict brain stimulation's mnemonic effects JF - CEREBRAL CORTEX J2 - CEREB CORTEX PY - 2023 PG - 13 SN - 1047-3211 DO - 10.1093/cercor/bhad427 UR - https://m2.mtmt.hu/api/publication/34593899 ID - 34593899 AB - Closed-loop direct brain stimulation is a promising tool for modulating neural activity and behavior. However, it remains unclear how to optimally target stimulation to modulate brain activity in particular brain networks that underlie particular cognitive functions. Here, we test the hypothesis that stimulation's behavioral and physiological effects depend on the stimulation target's anatomical and functional network properties. We delivered closed-loop stimulation as 47 neurosurgical patients studied and recalled word lists. Multivariate classifiers, trained to predict momentary lapses in memory function, triggered the stimulation of the lateral temporal cortex (LTC) during the study phase of the task. We found that LTC stimulation specifically improved memory when delivered to targets near white matter pathways. Memory improvement was largest for targets near white matter that also showed high functional connectivity to the brain's memory network. These targets also reduced low-frequency activity in this network, an established marker of successful memory encoding. These data reveal how anatomical and functional networks mediate stimulation's behavioral and physiological effects, provide further evidence that closed-loop LTC stimulation can improve episodic memory, and suggest a method for optimizing neuromodulation through improved stimulation targeting. LA - English DB - MTMT ER - TY - JOUR AU - Hays, M.A. AU - Kamali, G. AU - Koubeissi, M.Z. AU - Sarma, S.V. AU - Crone, N.E. AU - Smith, R.J. AU - Kang, J.Y. TI - Towards optimizing single pulse electrical stimulation: High current intensity, short pulse width stimulation most effectively elicits evoked potentials JF - BRAIN STIMULATION J2 - BRAIN STIMUL VL - 16 PY - 2023 IS - 3 SP - 772 EP - 782 PG - 11 SN - 1935-861X DO - 10.1016/j.brs.2023.04.023 UR - https://m2.mtmt.hu/api/publication/34225841 ID - 34225841 N1 - Export Date: 30 October 2023 Correspondence Address: Hays, M.A.; Department of Biomedical Engineering, 600 N Wolfe St, Meyer 8-158, United States; email: mhays6@jhmi.edu LA - English DB - MTMT ER - TY - JOUR AU - Hays, Mark A. AU - Smith, Rachel J. AU - Wang, Yujing AU - Coogan, Christopher AU - Sarma, Sridevi V. AU - Crone, Nathan E. AU - Kang, Joon Y. TI - Cortico-cortical evoked potentials in response to varying stimulation intensity improves seizure localization JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 145 PY - 2023 SP - 119 EP - 128 PG - 10 SN - 1388-2457 DO - 10.1016/j.clinph.2022.08.024 UR - https://m2.mtmt.hu/api/publication/33865810 ID - 33865810 N1 - Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, United States Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States Cited By :3 Export Date: 30 October 2023 CODEN: CNEUF Correspondence Address: Hays, M.A.; Department of Biomedical Engineering, 600 N Wolfe St, Meyer 8-158, United States; email: mhays6@jhmi.edu AB - Objective: As single pulse electrical stimulation (SPES) is increasingly utilized to help localize the seizure onset zone (SOZ), it is important to understand how stimulation intensity can affect the ability to use cortico-cortical evoked potentials (CCEPs) to delineate epileptogenic regions.Methods: We studied 15 drug-resistant epilepsy patients undergoing intracranial EEG monitoring and SPES with titrations of stimulation intensity. The N1 amplitude and distribution of CCEPs elicited in the SOZ and non-seizure onset zone (nSOZ) were quantified at each intensity. The separability of the SOZ and nSOZ using N1 amplitudes was compared between models using responses to titrations, responses to one maximal intensity, or both.Results: At 2 mA and above, the increase in N1 amplitude with current intensity was greater for responses within the SOZ, and SOZ response distribution was maximized by 4-6 mA. Models incorporating titrations achieved better separability of SOZ and nSOZ compared to those using one maximal intensity. Conclusions: We demonstrated that differences in CCEP amplitude over a range of current intensities can improve discriminability of SOZ regions.Significance: This study provides insight into the underlying excitability of the SOZ and how differences in current-dependent amplitudes of CCEPs may be used to help localize epileptogenic sites.(c) 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Jedynak, Maciej AU - Boyer, Anthony AU - Chanteloup-Foret, Blandine AU - Bhattacharjee, Manik AU - Saubat, Carole AU - Tadel, Francois AU - Kahane, Philippe AU - David, Olivier AU - F TRACT Consortium, null TI - Variability of Single Pulse Electrical Stimulation Responses Recorded with Intracranial Electroencephalography in Epileptic Patients JF - BRAIN TOPOGRAPHY J2 - BRAIN TOPOGR VL - 36 PY - 2023 IS - 1 SP - 119 EP - 127 PG - 9 SN - 0896-0267 DO - 10.1007/s10548-022-00928-7 UR - https://m2.mtmt.hu/api/publication/33865811 ID - 33865811 N1 - Grenoble Institut Neurosciences, Université Grenoble Alpes, Inserm, U1216, Grenoble, 38000, France Aix Marseille Université, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France Neurology Department, CHU Grenoble Alpes, Grenoble, France Signal and Image Processing Institute, University of Southern California, Los Angeles, United States Cited By :1 Export Date: 30 October 2023 CODEN: BRTOE Correspondence Address: Jedynak, M.; Aix Marseille Université, France; email: maciej.jedynak@protonmail.com AB - Cohort studies of brain stimulations performed with stereo-electroencephalographic (SEEG) electrodes in epileptic patients allow to derive large scale functional connectivity. It is known, however, that brain responses to electrical or magnetic stimulation techniques are not always reproducible. Here, we study variability of responses to single pulse SEEG electrical stimulation. We introduce a second-order probability analysis, i.e. we extend estimation of connection probabilities, defined as the proportion of responses trespassing a statistical threshold (determined in terms of Z-score with respect to spontaneous neuronal activity before stimulation) over all responses and derived from a number of individual measurements, to an analysis of pairs of measurements.Data from 445 patients were processed. We found that variability between two equivalent measurements is substantial in particular conditions. For long ( > similar to 90 mm) distances between stimulating and recording sites, and threshold value Z = 3, correlation between measurements drops almost to zero. In general, it remains below 0.5 when the threshold is smaller than Z =4 or the stimulating current intensity is 1 mA. It grows with an increase of either of these factors. Variability is independent of interictal spiking rates in the stimulating and recording sites.We conclude that responses to SEEG stimulation in the human brain are variable, i.e. in a subject at rest, two stimulation trains performed at the same electrode contacts and with the same protocol can give discrepant results. Our findings highlight an advantage of probabilistic interpretation of such results even in the context of a single individual. LA - English DB - MTMT ER - TY - JOUR AU - Li, H. AU - Zhang, X. AU - Sun, X. AU - Dong, L. AU - Lu, H. AU - Yue, S. AU - Zhang, H. TI - Functional networks in prolonged disorders of consciousness JF - FRONTIERS IN NEUROSCIENCE J2 - FRONT NEUROSCI-SWITZ VL - 17 PY - 2023 PG - 11 SN - 1662-4548 DO - 10.3389/fnins.2023.1113695 UR - https://m2.mtmt.hu/api/publication/33732193 ID - 33732193 N1 - Rehabilitation Center, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, Jinan, China Department of Neurorehabilitation, China Rehabilitation Research Center, Beijing, China University of Health and Rehabilitation Sciences, Shandong, Qingdao, China Export Date: 4 April 2023 Correspondence Address: Yue, S.; Rehabilitation Center, Shandong, China; email: shouweiy@sdu.edu.cn Correspondence Address: Zhang, H.; Rehabilitation Center, Shandong, China; email: crrczh2020@163.com Funding details: Z181100001718066 Funding details: National Natural Science Foundation of China, NSFC, U1809209 Funding text 1: This work was supported by grants from the National Natural Science Foundation of China (Grant number: U1809209 to HZ) and the Clinical Application Research with Capital Characteristics (Grant number: Z181100001718066 to HL). AB - Prolonged disorders of consciousness (DoC) are characterized by extended disruptions of brain activities that sustain wakefulness and awareness and are caused by various etiologies. During the past decades, neuroimaging has been a practical method of investigation in basic and clinical research to identify how brain properties interact in different levels of consciousness. Resting-state functional connectivity within and between canonical cortical networks correlates with consciousness by a calculation of the associated temporal blood oxygen level-dependent (BOLD) signal process during functional MRI (fMRI) and reveals the brain function of patients with prolonged DoC. There are certain brain networks including the default mode, dorsal attention, executive control, salience, auditory, visual, and sensorimotor networks that have been reported to be altered in low-level states of consciousness under either pathological or physiological states. Analysis of brain network connections based on functional imaging contributes to more accurate judgments of consciousness level and prognosis at the brain level. In this review, neurobehavioral evaluation of prolonged DoC and the functional connectivity within brain networks based on resting-state fMRI were reviewed to provide reference values for clinical diagnosis and prognostic evaluation. Copyright © 2023 Li, Zhang, Sun, Dong, Lu, Yue and Zhang. LA - English DB - MTMT ER - TY - JOUR AU - Motzkin, J.C. AU - Kanungo, I. AU - D’Esposito, M. AU - Shirvalkar, P. TI - Network targets for therapeutic brain stimulation: towards personalized therapy for pain JF - FRONTIERS IN PAIN RESEARCH J2 - FRONT PAIN RES VL - 4 PY - 2023 SN - 2673-561X DO - 10.3389/fpain.2023.1156108 UR - https://m2.mtmt.hu/api/publication/34225842 ID - 34225842 N1 - Departments of Neurology and Anesthesia and Perioperative Care (Pain Management), University of California, San Francisco, San Francisco, CA, United States Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States Department of Psychology, University of California, Berkeley, Berkeley, CA, United States Cited By :1 Export Date: 30 October 2023 Correspondence Address: Shirvalkar, P.; Departments of Neurology and Anesthesia and Perioperative Care (Pain Management), United States; email: prasad.shirvalkar@ucsf.edu LA - English DB - MTMT ER - TY - JOUR AU - Nejatbakhsh, Amin AU - Fumarola, Francesco AU - Esteki, Saleh AU - Toyoizumi, Taro AU - Kiani, Roozbeh AU - Mazzucato, Luca TI - Predicting the effect of micro-stimulation on macaque prefrontal activity based on spontaneous circuit dynamics JF - PHYSICAL REVIEW RESEARCH J2 - PRRESEARCH VL - 5 PY - 2023 IS - 4 PG - 14 SN - 2643-1564 DO - 10.1103/PhysRevResearch.5.043211 UR - https://m2.mtmt.hu/api/publication/34578288 ID - 34578288 AB - A crucial challenge in targeted manipulation of neural activity is to identify perturbation sites whose stimulation exerts significant effects downstream with high efficacy, a procedure currently achieved by labor-intensive and potentially harmful trial and error. Can one predict the effects of electrical stimulation on neural activity based on the circuit dynamics during spontaneous periods? Here we show that the effects of single-site micro stimulation on ensemble activity in an alert monkey's prefrontal cortex can be predicted solely based on the ensemble's spontaneous activity. We first inferred the ensemble's causal flow based on the directed functional interactions inferred during spontaneous periods using convergent cross-mapping and showed that it uncovers a causal hierarchy between the recording electrodes. We find that causal flow inferred at rest successfully predicts the spatiotemporal effects of micro-stimulation. We validate the computational features underlying causal flow using ground truth data from recurrent neural network models, showing that it is robust to noise and common inputs. A detailed comparison between convergent-cross mapping and alternative methods based on information theory reveals the advantages of the former method in predicting perturbation effects. Our results elucidate the causal interactions within neural ensembles and will facilitate the design of intervention protocols and targeted circuit manipulations suitable for brain-machine interfaces. LA - English DB - MTMT ER - TY - JOUR AU - Parmigiani, S. AU - Ross, J.M. AU - Cline, C.C. AU - Minasi, C.B. AU - Gogulski, J. AU - Keller, C.J. TI - Reliability and Validity of Transcranial Magnetic Stimulation–Electroencephalography Biomarkers JF - BIOLOGICAL PSYCHIATRY: COGNITIVE NEUROSCIENCE AND NEUROIMAGING J2 - BIOLOGICAL PSYCHIATRY: COGNITIVE NEUROSCIENCE AND NEUROIMAGINING VL - In press PY - 2023 SP - In press SN - 2451-9022 DO - 10.1016/j.bpsc.2022.12.005 UR - https://m2.mtmt.hu/api/publication/34079558 ID - 34079558 N1 - Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, StanfordCalifornia, United States Veterans Affairs Palo Alto Healthcare System, and the Sierra Pacific Mental Illness, Research, Education, and Clinical Center, Palo Alto, California, United States Wu Tsai Neuroscience Institute, Stanford, California, United States Department of Clinical Neurophysiology, HUS Diagnostic Center, Clinical Neurosciences, Helsinki University Hospital and University of Helsinki, Helsinki, Finland Export Date: 28 July 2023 Correspondence Address: Keller, C.J.; Department of Psychiatry and Behavioral Sciences, Stanford; email: ckeller1@stanford.edu AB - Noninvasive brain stimulation and neuroimaging have revolutionized human neuroscience with a multitude of applications, including diagnostic subtyping, treatment optimization, and relapse prediction. It is therefore particularly relevant to identify robust and clinically valuable brain biomarkers linking symptoms to their underlying neural mechanisms. Brain biomarkers must be reproducible (i.e., have internal reliability) across similar experiments within a laboratory and be generalizable (i.e., have external reliability) across experimental setups, laboratories, brain regions, and disease states. However, reliability (internal and external) is not alone sufficient; biomarkers also must have validity. Validity describes closeness to a true measure of the underlying neural signal or disease state. We propose that these metrics, reliability and validity, should be evaluated and optimized before any biomarker is used to inform treatment decisions. Here, we discuss these metrics with respect to causal brain connectivity biomarkers from coupling transcranial magnetic stimulation (TMS) with electroencephalography (EEG). We discuss controversies around TMS-EEG stemming from the multiple large off-target components (noise) and relatively weak genuine brain responses (signal), as is unfortunately often the case in noninvasive human neuroscience. We review the current state of TMS-EEG recordings, which consist of a mix of reliable noise and unreliable signal. We describe methods for evaluating TMS-EEG biomarkers, including how to assess internal and external reliability across facilities, cognitive states, brain networks, and disorders and how to validate these biomarkers using invasive neural recordings or treatment response. We provide recommendations to increase reliability and validity, discuss lessons learned, and suggest future directions for the field. © 2022 LA - English DB - MTMT ER - TY - JOUR AU - Russo, Simone AU - Mikulan, Ezequiel AU - Zauli, Flavia Maria AU - Sartori, Ivana AU - Solbiati, Michela AU - Furregoni, Giulia AU - Porro, Marta AU - Revay, Martina AU - Rosanova, Mario AU - David, Olivier AU - Massimini, Marcello AU - Tassi, Laura AU - Pigorini, Andrea TI - Neocortical and medial temporal seizures have distinct impacts on brain responsiveness JF - EPILEPSIA J2 - EPILEPSIA PY - 2023 PG - 9 SN - 0013-9580 DO - 10.1111/epi.17580 UR - https://m2.mtmt.hu/api/publication/33865808 ID - 33865808 N1 - Department of Biomedical and Clinical Sciences “L. Sacco”, University of Milan, Milan, Italy Allen Institute for Brain Science, Seattle, WA, United States Department of Philosophy ‘Piero Martinetti’, University of Milan, Milan, Italy “Claudio Munari” Epilepsy Surgery Centre, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy Inserm, INS, Institut de Neurosciences des Systèmes, Aix Marseille Université, Marseille, France Azrieli Program in Brain, Mind and Consciousness, Canadian Institute for Advanced Research, Toronto, ON, Canada IRCCS, Fondazione Don Carlo Gnocchi, Milan, Italy Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milan, Italy Cited By :2 Export Date: 30 October 2023 CODEN: EPILA Correspondence Address: Pigorini, A.; Department of Biomedical, Italy; email: andrea.pigorini@unimi.it AB - Focal epileptic seizures are characterized by abnormal neuronal discharges that can spread to other cortical areas and interfere with brain activity, thereby altering the patient's experience and behavior. The origin of these pathological neuronal discharges encompasses various mechanisms that converge toward similar clinical manifestations. Recent studies have suggested that medial temporal lobe (MTL) and neocortical (NC) seizures are often underpinned by two characteristic onset patterns, which, respectively, affect and spare synaptic transmission in cortical slices. However, these synaptic alterations and their effects have never been confirmed or studied in intact human brains. To fill this gap, we here evaluate whether responsiveness of MTL and NC are differentially affected by focal seizures, using a unique data set of cortico-cortical evoked potentials (CCEPs) collected during seizures triggered by single-pulse electrical stimulation (SPES). We find that responsiveness is abruptly reduced by the onset of MTL seizures, despite increased spontaneous activity, whereas it is preserved in the case of NC seizures. The present results provide an extreme example of dissociation between responsiveness and activity and show that brain networks are diversely affected by the onset of MTL and NC seizures, thus extending at the whole brain level the evidence of synaptic alteration found in vitro. LA - English DB - MTMT ER - TY - JOUR AU - Seguin, C. AU - Jedynak, M. AU - David, O. AU - Mansour, S. AU - Sporns, O. AU - Zalesky, A. TI - Communication dynamics in the human connectome shape the cortex-wide propagation of direct electrical stimulation JF - NEURON J2 - NEURON PY - 2023 SN - 0896-6273 DO - 10.1016/j.neuron.2023.01.027 UR - https://m2.mtmt.hu/api/publication/33762939 ID - 33762939 N1 - Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, VIC, Australia Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, United States Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale, Institut de Neurosciences des Systèmes (INS) UMR1106, Marseille, 13005, France Department of Biomedical Engineering, Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC, Australia Cognitive Science Program, Indiana University, Bloomington, IN, United States Program in Neuroscience, Indiana University, Bloomington, IN, United States Network Science Institute, Indiana University, Bloomington, IN, United States Export Date: 20 April 2023 CODEN: NERNE Correspondence Address: Seguin, C.; Melbourne Neuropsychiatry Centre, Australia; email: caio.seguin@unimelb.edu.au LA - English DB - MTMT ER - TY - JOUR AU - Wu, D. AU - Schaper, F.L.W.V.J. AU - Jin, G. AU - Qi, L. AU - Du, J. AU - Wang, X. AU - Wang, Y. AU - Xu, C. AU - Wang, X. AU - Yu, T. AU - Fox, M.D. AU - Ren, L. TI - Human anterior thalamic stimulation evoked cortical potentials align with intrinsic functional connectivity JF - NEUROIMAGE J2 - NEUROIMAGE VL - 277 PY - 2023 SN - 1053-8119 DO - 10.1016/j.neuroimage.2023.120243 UR - https://m2.mtmt.hu/api/publication/34225839 ID - 34225839 N1 - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China Clinical Research Center of Epilepsy, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China National Center for Neurological Disorders, Beijing, 100053, China Center of Brain Circuit Therapeutics, Departments of Neurology, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States Department of Pharmacy Phase I Clinical Trial Center, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China Berenson–Allen Center for Non-invasive Brain Stimulation, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02115, United States Martinos Center for Biomedical Imaging, Departments of Neurology and Radiology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02115, United States Havard Medical School, Boston, MA 02115, United States Chinese Institute for Brain Research, Beijing, 102206, China Cited By :1 Export Date: 30 October 2023 CODEN: NEIME Correspondence Address: Ren, L.; Department of Neurology, No.45, Changchun Street, China; email: renlk2022@outlook.com LA - English DB - MTMT ER - TY - JOUR AU - Zelmann, Rina AU - Paulk, Angelique C. AU - Tian, Fangyun AU - Villegas, Gustavo A. Balanza AU - Peralta, Jaquelin Dezha AU - Crocker, Britni AU - Cosgrove, G. Rees AU - Richardson, R. Mark AU - Williams, Ziv M. AU - Dougherty, Darin D. AU - Purdon, Patrick L. AU - Cash, Sydney S. TI - Differential cortical network engagement during states of un/consciousness in humans JF - NEURON J2 - NEURON VL - 111 PY - 2023 IS - 21 SP - 3479 EP - 3495 PG - 17 SN - 0896-6273 DO - 10.1016/j.neuron.2023.08.007 UR - https://m2.mtmt.hu/api/publication/34593900 ID - 34593900 AB - What happens in the human brain when we are unconscious? Despite substantial work, we are still unsure which brain regions are involved and how they are impacted when consciousness is disrupted. Using intracranial recordings and direct electrical stimulation, we mapped global, network, and regional involvement during wake vs. arousable unconsciousness (sleep) vs. non-arousable unconsciousness (propofol-induced general anesthesia). Information integration and complex processing we're reduced, while variability increased in any type of unconscious state. These changes were more pronounced during anesthesia than sleep and involved different cortical engagement. During sleep, changes were mostly uniformly distributed across the brain, whereas during anesthesia, the prefrontal cortex was the most disrupted, suggesting that the lack of arousability during anesthesia results not from just altered overall physiology but from a disconnection between the prefrontal and other brain areas. These findings provide direct evidence for different neural dynamics during loss of consciousness compared with loss of arousability. LA - English DB - MTMT ER - TY - JOUR AU - Parmigiani, S. AU - Mikulan, E. AU - Russo, S. AU - Sarasso, S. AU - Zauli, F. M. AU - Rubino, A. AU - Cattani, A. AU - Fecchio, M. AU - Giampiccolo, D. AU - Lanzone, J. AU - D'Orio, P. AU - Del Vecchio, M. AU - Avanzini, P. AU - Nobili, L. AU - Sartori, I AU - Massimini, M. AU - Pigorini, A. TI - Simultaneous stereo-EEG and high-density scalp EEG recordings to study the effects of intracerebral stimulation parameters JF - BRAIN STIMULATION J2 - BRAIN STIMUL VL - 15 PY - 2022 IS - 3 SP - 664 EP - 675 PG - 12 SN - 1935-861X DO - 10.1016/j.brs.2022.04.007 UR - https://m2.mtmt.hu/api/publication/32961414 ID - 32961414 N1 - Department of Biomedical and Clinical Sciences “L. Sacco” Università degli Studi di Milano, Milan, Italy Department of Philosophy “Piero Martinetti”, Università degli Studi di Milano, Milan, Italy “Claudio Munari” Epilepsy Surgery Centre, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy Department of Mathematics & Statistics, Boston University, Boston, MA, United States Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, United States Department of Neurosurgery, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom Institute of Neurosciences, Cleveland Clinic London, London, United Kingdom Department of Systems Medicine, Neuroscience, University of Rome Tor Vergata, Rome, Italy Istituti Clinici Scientifici Maugeri, IRCCS, Neurorehabilitation Department of Milano Institute, Milan, Italy Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, Parma, Italy Department of Medicine and Surgery, Unit of Neuroscience, University of Parma, Parma, Italy Child Neuropsychiatry, IRCCS Istituto G. Gaslini, Genova, Italy Department of Neuroscience, DINOGMI, University of Genoa, Genoa, Italy Istituto Di Ricovero e Cura a Carattere Scientifico, Fondazione Don Carlo Gnocchi, Milan, Italy Azrieli Program in Brain, Mind and Consciousness, Canadian Institute for Advanced Research, Toronto, Canada Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milan, Italy Cited By :5 Export Date: 30 October 2023 Correspondence Address: Pigorini, A.; Department of Biomedical and Clinical Sciences “L. Sacco” Università degli Studi di MilanoItaly; email: andrea.pigorini@unimi.it AB - Background: Cortico-cortical evoked potentials (CCEPs) recorded by stereo-electroencephalography (SEEG) are a valuable tool to investigate brain reactivity and effective connectivity. However, invasive recordings are spatially sparse since they depend on clinical needs. This sparsity hampers systematic comparisons across-subjects, the detection of the whole-brain effects of intracortical stimulation, as well as their relationships to the EEG responses evoked by non-invasive stimuli. Objective: To demonstrate that CCEPs recorded by high-density electroencephalography (hd-EEG) provide additional information with respect SEEG alone and to provide an open, curated dataset to allow for further exploration of their potential. Methods: The dataset encompasses SEEG and hd-EEG recordings simultaneously acquired during Single Pulse Electrical Stimulation (SPES) in drug-resistant epileptic patients (N 1/4 36) in whom stimulations were delivered with different physical, geometrical, and topological parameters. Differences in CCEPs were assessed by amplitude, latency, and spectral measures. Results: While invasively and non-invasively recorded CCEPs were generally correlated, differences in pulse duration, angle and stimulated cortical area were better captured by hd-EEG. Further, intracranial stimulation evoked site-specific hd-EEG responses that reproduced the spectral features of EEG responses to transcranial magnetic stimulation (TMS). Notably, SPES, albeit unperceived by subjects, elicited scalp responses that were up to one order of magnitude larger than the responses typically evoked by sensory stimulation in awake humans. Conclusions: CCEPs can be simultaneously recorded with SEEG and hd-EEG and the latter provides a reliable descriptor of the effects of SPES as well as a common reference to compare the whole-brain LA - English DB - MTMT ER - TY - JOUR AU - Patel, Prachi AU - Khalijhinejad, Bahar AU - Herrero, Jose L. AU - Bickel, Stephan AU - Mehta, Ashesh D. AU - Mesgarani, Nima TI - Improved speech hearing in noise with invasive electrical brain stimulation JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 42 PY - 2022 IS - 17 PG - 31 SN - 0270-6474 DO - 10.1523/JNEUROSCI.1468-21.2022 UR - https://m2.mtmt.hu/api/publication/33006199 ID - 33006199 N1 - Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, United States Department of Electrical Engineering, Columbia University, New York, NY 10027, United States Hofstra Northwell School of Medicine, New York, NY 11549, United States Feinstein Institute for Medical Research, New York, NY 11030, United States Cited By :1 Export Date: 30 October 2023 CODEN: JNRSD Correspondence Address: Mesgarani, N.; Mortimer B. Zuckerman Mind Brain Behavior Institute, United States; email: nima@ee.columbia.edu AB - Speech perception in noise is a challenging everyday task with which many listeners have difficulty. Here, we report a case in which electrical brain stimulation of implanted intracranial electrodes in the left planum temporale (PT) of a neurosurgical patient significantly and reliably improved subjectivequality (up to 50%) and objective intelligibility (up to 97%) of speech in noise perception. Stimulation resulted in a selective enhancement of speech sounds compared to the background noises. Thereceptive fields of the PT sites whose stimulation improved speech perception were tuned to spectrally broad and rapidly changing sounds. Corticocortical evoked potential analysis revealed that the PT sites were located between the sites in Heschl's gyrus (HG) and the superior temporal gyrus (STG). Moreover, the discriminability of speech from nonspeech sounds increased in population neural responses from HG to the PT to the STG sites. These findings causally implicate the PT in background noise suppression and may point to a novel potential neuroprosthetic solution to assist in the challenging task of speech perception in noise.SignificanceSpeech perception in noise remains a challenging task for many individuals. Here, we present a case in which the electrical brain stimulation of intracranially implanted electrodes in the planum temporale of a neurosurgical patient significantly improved both the subjective quality (up to 50%) and objective intelligibility (up to 97%) of speech perception in noise. Stimulation resulted in a selective enhancement of speech sounds compared to the background noises. Our local and network-level functional analyses placed the planum temporale sites in between the sites in the primary auditory areas in Heschl's gyrus and nonprimary auditory areas in the superior temporal gyrus. These findings causally implicate planum temporale in acoustic scene analysis and suggest potential neuroprosthetic applications to assist hearing in noise. LA - English DB - MTMT ER - TY - JOUR AU - Titov, Oleg AU - Bykanov, Andrey AU - Pitskhelauri, David AU - Danilov, Gleb TI - Neuromonitoring of the language pathways using cortico-cortical evoked potentials: a systematic review and meta-analysis JF - NEUROSURGICAL REVIEW J2 - NEUROSURG REV VL - 45 PY - 2022 IS - 3 SP - 1883 EP - 1894 PG - 12 SN - 0344-5607 DO - 10.1007/s10143-021-01718-8 UR - https://m2.mtmt.hu/api/publication/32961415 ID - 32961415 N1 - Funding Agency and Grant Number: Russian Foundation for Basic Research [19-29-01231] Funding text: The reported study was supported by the Russian Foundation for Basic Research (grant number 19-29-01231). AB - Cortico-cortical evoked potentials (CCEPs) are a surge in activity of one cortical zone caused by stimulation of another cortical zone. Recording of CCEP may be a useful method of intraoperative monitoring of the brain pathways, particularly of the language-related tracts. We aimed to conduct a systematic review and meta-analysis, dedicated to the clinical question: Does the CCEP recording effectively predict the postoperative speech deficits in neurosurgical patients? We conducted language-restricted PubMed, Google Scholar, Scopus, and Cochrane database search for eligible studies of CCEP published until March 2021. There were 4 articles (3 case series and 1 case report), which met our inclusion/exclusion criteria. A total of 32 patients (30 cases of tumors and 2 cavernomas) included in the analysis were divided into two cohorts - quantitative and qualitative, in accordance with the method of evaluating changes in the amplitude of CCEP after the lesion resection and postoperative alterations in speech function. Quantitative variables were studied using the Spearman rank correlation coefficient. Categorical variables were compared in groups by Fisher's exact test. We found a strong positive correlation between the decrease in the N1 wave amplitude and the severity of postoperative speech deficits (quantitative cohort: r = 0.57, p = 0.01; qualitative cohort: p = 0.02). Thus, the CCEP method using the N1 wave amplitude as a marker enables to effectively predict postoperative speech outcomes. Nevertheless, the low level of evidence for the included works indicated the necessity for additional research on this issue. LA - English DB - MTMT ER - TY - JOUR AU - Togo, Masaya AU - Matsumoto, Riki AU - Usami, Kiyohide AU - Kobayashi, Katsuya AU - Takeyama, Hirofumi AU - Nakae, Takuro AU - Shimotake, Akihiro AU - Kikuchi, Takayuki AU - Yoshida, Kazumichi AU - Matsuhashi, Masao AU - Kunieda, Takeharu AU - Miyamoto, Susumu AU - Takahashi, Ryosuke AU - Ikeda, Akio TI - Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential JF - NEUROIMAGE J2 - NEUROIMAGE VL - 263 PY - 2022 PG - 14 SN - 1053-8119 DO - 10.1016/j.neuroimage.2022.119639 UR - https://m2.mtmt.hu/api/publication/33229822 ID - 33229822 N1 - Funding Agency and Grant Number: Ministry of Education, Culture, Sports, Science and Technology (MEXT) KAKENHI; Ministry of Education, Culture, Sports, Science and Technology (MEXT) KAKENHI [18K19514, 20H05471, 22H04777, 22H02945, 20K16575, 19H03574] Funding text: This work was supported by the Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) KAKENHI. RM reports grants from MEXT, KAKENHI 18K19514, 20H05471, 22H04777, 22H02945, MT reports grants from 20K16575, and AI reports grants from 19H03574. We would like to thank Prof. Naoyuki Sato for his technical advice and help in performing the per-mutation test. AB - The medial parietal cortices are components of the default mode network (DMN), which are active in the resting state. The medial parietal cortices include the precuneus and the dorsal posterior cingulate cortex (dPCC). Few studies have mentioned differences in the connectivity in the medial parietal cortices, and these differences have not yet been precisely elucidated. Electrophysiological connectivity is essential for understanding cortical function or functional differences. Since little is known about electrophysiological connections from the medial parietal cortices in humans, we evaluated distinct connectivity patterns in the medial parietal cortices by constructing a standardized connectivity map using cortico-cortical evoked potential (CCEP). This study included nine patients with partial epilepsy or a brain tumor who underwent chronic intracranial electrode placement covering the medial parietal cortices. Single-pulse electrical stimuli were delivered to the medial parietal cortices (38 pairs of electrodes). Responses were standardized using the z-score of the baseline activity, and a response density map was constructed in the Montreal Neurological Institutes (MNI) space. The precuneus tended to connect with the inferior parietal lobule (IPL), the occipital cortex, superior parietal lobule (SPL), and the dorsal premotor area (PMd) (the four most active regions, in descending order), while the dPCC tended to connect to the middle cingulate cortex, SPL, precuneus, and IPL. The connectivity pattern differs significantly between the precuneus and dPCC stimulation ( p < 0.05). Regarding each part of the medial parietal cortices, the distributions of parts of CCEP responses resembled those of the functional connectivity database. Based on how the dPCC was connected to the medial frontal area, SPL, and IPL, its connectivity pattern could not be explained by DMN alone, but suggested a mixture of DMN and the frontoparietal cognitive network. These findings improve our understanding of the connectivity profile within the medial parietal cortices. The electrophysiological connectivity is the basis of propagation of electrical activities in patients with epilepsy. In addition, it helps us to better understand the epileptic network arising from the medial parietal cortices. LA - English DB - MTMT ER - TY - JOUR AU - Zauli, F. M. AU - Del Vecchio, M. AU - Russo, S. AU - Mariani, V AU - Pelliccia, V AU - d'Orio, P. AU - Sartori, I AU - Avanzini, P. AU - Caruana, F. TI - The web of laughter: frontal and limbic projections of the anterior cingulate cortex revealed by cortico-cortical evoked potential from sites eliciting laughter JF - PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B - BIOLOGICAL SCIENCES J2 - PHILOS T ROY SOC B VL - 377 PY - 2022 IS - 1863 PG - 12 SN - 0962-8436 DO - 10.1098/rstb.2021.0180 UR - https://m2.mtmt.hu/api/publication/33167977 ID - 33167977 N1 - Funding Agency and Grant Number: European Union Horizon 2020; [785907] Funding text: M.D.V. was supported by European Union Horizon 2020 Framework Programme through Grant Agreement no. 785907 (HumanBrain Project, SGA2) to P.A. AB - According to an evolutionist approach, laughter is a multifaceted behaviour affecting social, emotional, motor and speech functions. Albeit previous studies have suggested that high-frequency electrical stimulation (HF-ES) of the pregenual anterior cingulate cortex (pACC) may induce bursts of laughter-suggesting a crucial contribution of this region to the cortical control of this behaviour-the complex nature of laughter implies that outward connections from the pACC may reach and affect a complex network of frontal and limbic regions. Here, we studied the effective connectivity of the pACC by analysing the cortico-cortical evoked potentials elicited by single-pulse electrical stimulation of pACC sites whose HF-ES elicited laughter in 12 patients. Once these regions were identified, we studied their clinical response to HF-ES, to reveal the specific functional target of pACC representation of laughter. Results reveal that the neural representation of laughter in the pACC interacts with several frontal and limbic regions, including cingulate, orbitofrontal, medial prefrontal and anterior insular regions-involved in interoception, emotion, social reward and motor behaviour. These results offer neuroscientific support to the evolutionist approach to laughter, providing a possible mechanistic explanation of the interplay between this behaviour and emotion regulation, speech production and social interactions.This article is part of the theme issue 'Cracking the laugh code: laughter through the lens of biology, psychology and neuroscience'. LA - English DB - MTMT ER - TY - JOUR AU - Giampiccolo, D. AU - Parmigiani, S. AU - Basaldella, F. AU - Russo, S. AU - Pigorini, A. AU - Rosanova, M. AU - Cattaneo, L. AU - Sala, F. TI - Recording cortico-cortical evoked potentials of the human arcuate fasciculus under general anaesthesia JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 132 PY - 2021 IS - 8 SP - 1966 EP - 1973 PG - 8 SN - 1388-2457 DO - 10.1016/j.clinph.2021.03.044 UR - https://m2.mtmt.hu/api/publication/32277265 ID - 32277265 N1 - Funding Agency and Grant Number: Fondazione Cariverona (Progetto Neuro-Connect); University of Verona (Bando Ricerca di Base); European Union's Horizon 2020 Framework Programme for Research and Innovation [945539]; Tiny Blue Dot Foundation Funding text: This work was supported by Fondazione Cariverona (Progetto Neuro-Connect), the University of Verona (Bando Ricerca di Base), the European Union's Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No.945539 (Human Brain Project SGA3 to S.P., A.P., S.R. and M.R.), and from the Tiny Blue Dot Foundation (to S.P., A.P., S.R. and M.R.). AB - Objective: We examined the feasibility of using cortico-cortical evoked potentials (CCEPs) to monitor the major cortical white matter tract involved in language, the arcuate fasciculus (AF), during surgery under general anaesthesia.Methods: We prospectively recruited nine patients undergoing surgery for lesions in the left peri-sylvian cortex, for whom awake surgery was not indicated. High angular resolution diffusion imaging (HARDI) tractography was used to localise frontal and temporal AF terminations, which guided intraoperative cortical strip placement.Results: CCEPs were successfully evoked in 5/9 patients, showing a positive potential (P1) at 12 ms and a negative component (N1) at 21 ms when stimulating from the frontal lobe and recording in the temporal lobe. CCEP responses peaked in the posterior middle temporal gyrus. No CCEPs were evoked when stimulating temporal sites and recording from frontal contacts.Conclusion: For the first time, we show that CCEPs can be evoked from the peri-sylvian cortices also in adult patients who are not candidates for awake procedures. Our results are akin to those described in the awake setting and suggest the recorded activity is conveyed by the arcuate fasciculus.Significance: This intraoperative approach may have promising implications in reducing deficits in patients that require surgery in language areas under general anesthesia. (C) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Guo, Zhihao AU - Zhao, Baotian AU - Hu, Wenhan AU - Zhang, Chao AU - Wang, Xiu AU - Wang, Yao AU - Liu, Chang AU - Mo, Jiajie AU - Sang, Lin AU - Ma, Yanshan AU - Shao, Xiaoqiu AU - Zhang, Jianguo AU - Zhang, Kai TI - Effective connectivity among the hippocampus, amygdala, and temporal neocortex in epilepsy patients: A cortico-cortical evoked potential study JF - EPILEPSY & BEHAVIOR J2 - EPILEPSY BEHAV VL - 115 PY - 2021 PG - 7 SN - 1525-5050 DO - 10.1016/j.yebeh.2020.107661 UR - https://m2.mtmt.hu/api/publication/32277272 ID - 32277272 N1 - Funding Agency and Grant Number: National Natural Science Foundation of China [81771399, 81701276]; Beijing Municipal Science & Technology Commission [Z171100001017069]; Capital's Funds for Health Improvement and Research [2020-41076] Funding text: This study was supported by the National Natural Science Foundation of China (No. 81771399, 81701276), the Beijing Municipal Science & Technology Commission (Z171100001017069) and the Capital's Funds for Health Improvement and Research (2020-41076). AB - Objective: Mesial temporal lobe epilepsy (MTLE) is one of the most common types of intractable epilepsy. The hippocampus and amygdala are two crucial structures of the mesial temporal lobe and play important roles in the epileptogenic network of MTLE. This study aimed to explore the effective connectivity among the hippocampus, amygdala, and temporal neocortex and to determine whether differences in effective connectivity exist between MTLE patients and non-MTLE patients.Methods: This study recruited 20 patients from a large cohort of drug-resistant epilepsy patients, of whom 14 were MTLE patients. Single-pulse electrical stimulation (SPES) was performed to acquire cortico-cortical evoked potentials (CCEPs). The root mean square (RMS) was used as the metric of the magnitude of CCEP to represent the effective connectivity. We then conducted paired and independent sample t-tests to assess the directionality of the effective connectivity.Results: In both MTLE patients and non-MTLE patients, the directional connectivity from the amygdala to the hippocampus was stronger than that from the hippocampus to the amygdala (P < 0.01); the outward connectivity from the amygdala to the cortex was stronger than the inward connectivity from the cortex to the amygdala (P < 0.01); the amygdala had stronger connectivity to the neocortex than the hippocampus (P < 0.01). In MTLE patients, the neocortex had stronger connectivity to the hippocampus than to the amygdala (P < 0.01). No significant differences in directional connectivity were noted between the two groups.Conclusions: A unique effective connectivity pattern among the hippocampus, amygdala, and temporal neocortex was identified through CCEPs analysis. This study may aid in our understanding of physiological and pathological networks in the brain and inspire neurostimulation protocols for neurological and psychiatric disorders. (C) 2020 Elsevier Inc. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Hays, A. Mark AU - Smith, J. Rachel AU - Haridas, Babitha AU - Coogan, Christopher AU - Crone, E. Nathan AU - Kang, Y. Joon TI - Effects of stimulation intensity on intracranial cortico-cortical evoked potentials: A titration study JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 132 PY - 2021 IS - 11 SP - 2766 EP - 2777 PG - 12 SN - 1388-2457 DO - 10.1016/j.clinph.2021.08.008 UR - https://m2.mtmt.hu/api/publication/32961418 ID - 32961418 N1 - Funding Agency and Grant Number: NIH NINDS [R01 NS091139] Funding text: This work was supported by the NIH NINDS Grant R01 NS115929 and the NIH NINDS Grant R01 NS091139. AB - Objective: The aim of the present study was to investigate the optimal stimulation parameters for elicit-ing cortico-cortical evoked potentials (CCEPs) for mapping functional and epileptogenic networks. Methods: We studied 13 patients with refractory epilepsy undergoing intracranial EEG monitoring. We systematically titrated the intensity of single-pulse electrical stimulation at multiple sites to assess the effect of increasing current on salient features of CCEPs such as N1 potential magnitude, signal to noise ratio, waveform similarity, and spatial distribution of responses. Responses at each incremental stimula-tion setting were compared to each other and to a final set of responses at the maximum intensity used in each patient (3.5-10 mA, median 6 mA). Results: We found that with a biphasic 0.15 ms/phase pulse at least 2-4 mA is needed to differentiate between non-responsive and responsive sites, and that stimulation currents of 6-7 mA are needed to maximize amplitude and spatial distribution of N1 responses and stabilize waveform morphology. Conclusions: We determined a minimum stimulation threshold necessary for eliciting CCEPs, as well as a point at which the current-dependent relationship of several response metrics all saturate. Significance: This titration study provides practical, immediate guidance on optimal stimulation parameters to study specific features of CCEPs, which have been increasingly used to map both functional and epileptic brain networks in humans. CO 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Hays, Mark A. AU - Coogan, Christopher AU - Crone, Nathan E. AU - Kang, Joon Y. TI - Graph theoretical analysis of evoked potentials shows network influence of epileptogenic mesial temporal region JF - HUMAN BRAIN MAPPING J2 - HUM BRAIN MAPP VL - 42 PY - 2021 IS - 13 SP - 4173 EP - 4186 PG - 14 SN - 1065-9471 DO - 10.1002/hbm.25418 UR - https://m2.mtmt.hu/api/publication/32277263 ID - 32277263 N1 - Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States Cited By :2 Export Date: 21 October 2022 CODEN: HBMAE Correspondence Address: Crone, N.E.; Department of Neurology, United States; email: ncrone@jhmi.edu Tradenames: AdTech; Neurofax, Nihon Kohden, Japan Manufacturers: Nihon Kohden, Japan AB - It is now widely accepted that seizures arise from the coordinated activity of epileptic networks, and as a result, traditional methods of analyzing seizures have been augmented by techniques like single-pulse electrical stimulation (SPES) that estimate effective connectivity in brain networks. We used SPES and graph analytics in 18 patients undergoing intracranial EEG monitoring to investigate effective connectivity between recording sites within and outside mesial temporal structures. We compared evoked potential amplitude, network density, and centrality measures inside and outside the mesial temporal region (MTR) across three patient groups: focal epileptogenic MTR, multifocal epileptogenic MTR, and non-epileptogenic MTR. Effective connectivity within the MTR had significantly greater magnitude (evoked potential amplitude) and network density, regardless of epileptogenicity. However, effective connectivity between MTR and surrounding non-epileptogenic regions was of greater magnitude and density in patients with focal epileptogenic MTR compared to patients with multifocal epileptogenic MTR and those with non-epileptogenic MTR. Moreover, electrodes within focal epileptogenic MTR had significantly greater outward network centrality compared to electrodes outside non-epileptogenic regions and to multifocal and non-epileptogenic MTR. Our results indicate that the MTR is a robustly connected subnetwork that can exert an overall elevated propagative influence over other brain regions when it is epileptogenic. Understanding the underlying effective connectivity and roles of epileptogenic regions within the larger network may provide insights that eventually lead to improved surgical outcomes. LA - English DB - MTMT ER - TY - JOUR AU - Inoue, Takeshi AU - Uda, Takehiro AU - Kuki, Ichiro AU - Yamamoto, Naohiro AU - Nagase, Shizuka AU - Nukui, Megumi AU - Okazaki, Shin AU - Kawashima, Toshiyuki AU - Nakanishi, Yoko AU - Kunihiro, Noritsugu AU - Matsuzaka, Yasuhiro AU - Kawawaki, Hisashi AU - Otsubo, Hiroshi TI - Distinct dual cortico-cortical networks successfully identified between supplemental and primary motor areas during intracranial EEG for drug-resistant frontal lobe epilepsy JF - EPILEPSY & BEHAVIOR REPORTS J2 - EPILEPSY BEHAV REP VL - 15 PY - 2021 PG - 6 SN - 2589-9864 DO - 10.1016/j.ebr.2021.100429 UR - https://m2.mtmt.hu/api/publication/32277270 ID - 32277270 N1 - Funding Agency and Grant Number: MHLW Research program on rare and intractable diseases [JPMH20FC1039]; EpLink -the Epilepsy Research Program of the Ontario Brain Institute (OBI); Ontario government Funding text: This work was supported by MHLW Research program on rare and intractable diseases, Grant number JPMH20FC1039 (to I. Kuki). Dr. Otsubo was supported by the EpLink -the Epilepsy Research Program of the Ontario Brain Institute (OBI). OBI is an independent non-profit corporation, funded partially by the Ontario government. AB - We present a case of drug-resistant focal motor seizures in which separate cortico-cortical epileptic networks within the supplementary motor area (SMA) proper and primary motor area (PMA) were proven by ictal high-frequency oscillation (HFO) and cortico-cortical evoked potential (CCEP). A 12-year-old girl presented with two types seizures: type A, tonic extension and subsequent clonic movements of the right arm; and type B, tonic and clonic movements of the right leg. MRI was normal and karyotype genetic analysis revealed 46,X,t(X;14)(q13;p12). She underwent placement of chronic subdural electrodes over the left hemisphere. We recorded a total of nine seizures during 10 days of epilepsy monitoring. Type A seizures started from the lower part of the left SMA proper and early spread to the hand motor area of the PMA. Type B seizures started from the upper part of the SMA proper and early spread to the leg motor area of the PMA. CCEPs of both SMA proper and PMA activated two identical routes for evoked potentials correlating with separate pathways. Corticectomy of the left SMA proper and PMA achieved seizure-free without hemiparesis. Within a small homunculus of the SMA proper, separate epileptic networks were proven and validated by seizure semiology, ictal HFO, and CCEP. (C) 2021 The Author(s). Published by Elsevier Inc. LA - English DB - MTMT ER - TY - JOUR AU - Kajiyama, Yuta AU - Hattori, Noriaki AU - Nakano, Tomohito AU - Revankar, Gajanan S. AU - Otomune, Hironori AU - Hashimoto, Ryota AU - Mori, Etsuro AU - Ikeda, Manabu AU - Mihara, Masahito AU - Mochizuki, Hideki TI - Decreased frontotemporal connectivity in patients with parkinson's disease experiencing face pareidolia JF - NPJ PARKINSONS DISEASE J2 - NPJ PARKINSONS DIS VL - 7 PY - 2021 IS - 1 PG - 9 SN - 2373-8057 DO - 10.1038/s41531-021-00237-z UR - https://m2.mtmt.hu/api/publication/32961417 ID - 32961417 N1 - Funding Agency and Grant Number: Japan Society for the Promotion of Science (JSPS) [16K01453]; JSPS [20H04044]; Brain Mapping by Integrated Neuroethologies for Disease Studies from the Japan Agency for Medical Research and Development (AMED) [JP21dm0207070] Funding text: We would like to thank Editage (www.editage.com) for English language editing. This research was funded by Grant-in-Aid for Scientific Research C (16K01453) from the Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Scientific Research B (20H04044) from JSPS and The Brain Mapping by Integrated Neuroethologies for Disease Studies (JP21dm0207070) from the Japan Agency for Medical Research and Development (AMED). AB - The precise neural underpinnings of face pareidolia in patients with Parkinson's disease (PD) remain unclear. We aimed to clarify face recognition network abnormalities associated with face pareidolia in such patients. Eighty-three patients with PD and 40 healthy controls were recruited in this study. Patients with PD were classified into pareidolia and nonpareidolia groups. Volumetric analyses revealed no significant differences between the pareidolia (n = 39) and nonpareidolia (n = 44) patient groups. We further observed decreased functional connectivity among regions of interest in the bilateral frontotemporal lobes in patients with pareidolia. Seed-based analysis using bilateral temporal fusiform cortices as seeds revealed significantly decreased connectivity with the bilateral inferior medial prefrontal cortices in the pareidolia group. Post hoc regression analysis further demonstrated that the severity of face pareidolia was negatively correlated with functional connectivity between the bilateral temporal fusiform and medial prefrontal cortices. Our findings suggest that top-down modulation of the face recognition network is impaired in patients with PD experiencing face pareidolia. LA - English DB - MTMT ER - TY - JOUR AU - Neumann, L. AU - Wulms, N. AU - Witte, V. AU - Spisak, T. AU - Zunhammer, M. AU - Bingel, U. AU - Schmidt-Wilcke, T. TI - Network properties and regional brain morphology of the insular cortex correlate with individual pain thresholds JF - HUMAN BRAIN MAPPING J2 - HUM BRAIN MAPP VL - 42 PY - 2021 IS - 15 SP - 4896 EP - 4908 PG - 13 SN - 1065-9471 DO - 10.1002/hbm.25588 UR - https://m2.mtmt.hu/api/publication/32172466 ID - 32172466 N1 - Medizinische Klinik I, Klinik für Innere Medizin, Nephrologie und Dialyse, Osteologie und Rheumatologie, St. Franziskus-Hospital Münster, Münster, Germany Institut für Epidemiologie und Sozialmedizin, Universitätsklinikum Münster, Münster, Germany Klinik für Dermatologie, Venerologie und Allergologie, St. Josef-Hospital Bochum, Ruhr-Universität Bochum, Bochum, Germany Klinik für Neurologie, Universitätsklinikum Essen, Essen, Germany Institut für Klinische Neurowissenschaften und Medizinische Psychologie, Heinrich Heine Universität, Düsseldorf, Germany Neurologisches Zentrum, Bezirksklinikum Mainkofen, Deggendorf, Germany Export Date: 2 September 2021 CODEN: HBMAE Correspondence Address: Schmidt-Wilcke, T.; Institut für Klinische Neurowissenschaften und Medizinische Psychologie, Germany; email: tobias-schmidt-wilcke@t-online.de Funding details: Deutsche Forschungsgemeinschaft, DFG, 122679504, 422744262–TRR 289, SCH 2665/4‐1, SFB 874/A08 Funding text 1: This work was supported by a grant from the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) to Tobias Schmidt‐Wilcke (SFB 874/A08, project number: 122679504 and by a DFG Einzelantrag: Dyscognition in chronic pain, SCH 2665/4‐1). Ulrike Bingel and Tamas Spisak were funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)—Project‐ID 422744262–TRR 289. Medizinische Klinik I, Klinik für Innere Medizin, Nephrologie und Dialyse, Osteologie und Rheumatologie, St. Franziskus-Hospital Münster, Münster, Germany Institut für Epidemiologie und Sozialmedizin, Universitätsklinikum Münster, Münster, Germany Klinik für Dermatologie, Venerologie und Allergologie, St. Josef-Hospital Bochum, Ruhr-Universität Bochum, Bochum, Germany Klinik für Neurologie, Universitätsklinikum Essen, Essen, Germany Institut für Klinische Neurowissenschaften und Medizinische Psychologie, Heinrich Heine Universität, Düsseldorf, Germany Neurologisches Zentrum, Bezirksklinikum Mainkofen, Deggendorf, Germany Export Date: 17 September 2021 CODEN: HBMAE Correspondence Address: Schmidt-Wilcke, T.; Institut für Klinische Neurowissenschaften und Medizinische Psychologie, Germany; email: tobias-schmidt-wilcke@t-online.de Funding details: Deutsche Forschungsgemeinschaft, DFG, 122679504, 422744262–TRR 289, SCH 2665/4‐1, SFB 874/A08 Funding text 1: This work was supported by a grant from the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) to Tobias Schmidt‐Wilcke (SFB 874/A08, project number: 122679504 and by a DFG Einzelantrag: Dyscognition in chronic pain, SCH 2665/4‐1). Ulrike Bingel and Tamas Spisak were funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)—Project‐ID 422744262–TRR 289. AB - Pain thresholds vary considerably across individuals and are influenced by a number of behavioral, genetic and neurobiological factors. However, the neurobiological underpinnings that account for individual differences remain to be fully elucidated. In this study, we used voxel-based morphometry (VBM) and graph theory, specifically the local clustering coefficient (CC) based on resting-state connectivity, to identify brain regions, where regional gray matter volume and network properties predicted individual pain thresholds. As a main finding, we identified a cluster in the left posterior insular cortex (IC) reaching into the left parietal operculum, including the secondary somatosensory cortex, where both regional gray matter volume and the local CC correlated with individual pain thresholds. We also performed a resting-state functional connectivity analysis using the left posterior IC as seed region, demonstrating that connectivity to the pre- as well as postcentral gyrus bilaterally; that is, to the motor and primary sensory cortices were correlated with individual pain thresholds. To our knowledge, this is the first study that applied VBM in combination with voxel-based graph theory in the context of pain thresholds. The co-location of the VBM and the local CC cluster provide first evidence that both structure and function map to the same brain region while being correlated with the same behavioral measure; that is, pain thresholds. The study highlights the importance of the posterior IC, not only for pain perception in general, but also for the determination of individual pain thresholds. © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. LA - English DB - MTMT ER - TY - JOUR AU - Oathes, Desmond J. AU - Balderston, Nicholas L. AU - Kording, Konrad P. AU - DeLuisi, Joseph A. AU - Perez, Gianna M. AU - Medaglia, John D. AU - Fan, Yong AU - Duprat, Romain J. AU - Satterthwaite, Theodore D. AU - Sheline, Yvette I. AU - Linn, Kristin A. TI - Combining transcranial magnetic stimulation with functional magnetic resonance imaging for probing and modulating neural circuits relevant to affective disorders JF - WILEY INTERDISCIPLINARY REVIEWS-COGNITIVE SCIENCE J2 - WIRES COGN SCI VL - 12 PY - 2021 IS - 4 PG - 16 SN - 1939-5078 DO - 10.1002/wcs.1553 UR - https://m2.mtmt.hu/api/publication/32277269 ID - 32277269 N1 - Funding Agency and Grant Number: National Institute of Mental Health [K01 MH121777, R01 MH111886, R01 MH120811, RF1 MH116920, U01 MH 109991]; NIH Office of the Director [DP5 OD021352] Funding text: National Institute of Mental Health, Grant/Award Numbers: K01 MH121777, R01 MH111886, R01 MH120811, RF1 MH116920, U01 MH 109991; NIH Office of the Director, Grant/Award Number: DP5 OD021352 AB - Combining transcranial magnetic stimulation (TMS) with functional magnetic resonance imaging offers an unprecedented tool for studying how brain networks interact in vivo and how repetitive trains of TMS modulate those networks among patients diagnosed with affective disorders. TMS compliments neuroimaging by allowing the interrogation of causal control among brain circuits. Together with TMS, neuroimaging can provide valuable insight into the mechanisms underlying treatment effects and downstream circuit communication. Here we provide a background of the method, review relevant study designs, consider methodological and equipment options, and provide statistical recommendations. We conclude by describing emerging approaches that will extend these tools into exciting new applications.This article is categorized under:Psychology > Emotion and MotivationPsychology > Theory and MethodsNeuroscience > Clinical Neuroscience LA - English DB - MTMT ER - TY - JOUR AU - Oathes, Desmond J. AU - Zimmerman, Jared P. AU - Duprat, Romain AU - Japp, Seda S. AU - Scully, Morgan AU - Rosenberg, Benjamin M. AU - Flounders, Matthew W. AU - Long, Hannah AU - Deluisi, Joseph A. AU - Elliott, Mark AU - Shandler, Gavriella AU - Shinohara, Russell T. AU - Linn, Kristin A. TI - Resting fMRI-guided TMS results in subcortical and brain network modulation indexed by interleaved TMS/fMRI JF - EXPERIMENTAL BRAIN RESEARCH J2 - EXP BRAIN RES VL - 239 PY - 2021 IS - 4 SP - 1165 EP - 1178 PG - 14 SN - 0014-4819 DO - 10.1007/s00221-021-06036-5 UR - https://m2.mtmt.hu/api/publication/32277264 ID - 32277264 N1 - Funding Agency and Grant Number: National Institutes of Health NIH [R01 MH111886]; NIH [RF1 MH116920] Funding text: This work was supported by the National Institutes of Health NIH R01 MH111886 (DJO) and NIH RF1 MH116920 (DJO). The funder had no role in study design; collection and analysis of data; in writing the report; or in the decision to submit the article for publication. AB - Traditional non-invasive imaging methods describe statistical associations of functional co-activation over time. They cannot easily establish hierarchies in communication as done in non-human animals using invasive methods. Here, we interleaved functional MRI (fMRI) recordings with non-invasive transcranial magnetic stimulation (TMS) to map causal communication between the frontal cortex and subcortical target structures including the subgenual anterior cingulate cortex (sgACC) and the amygdala. Seed-based correlation maps from each participant's resting fMRI scan determined individual stimulation sites with high temporal correlation to targets for the subsequent TMS/fMRI session(s). The resulting TMS/fMRI images were transformed to quantile responses, so that regions of high-/low-quantile response corresponded to the areas of the brain with the most positive/negative evoked response relative to the global brain response. We then modeled the average quantile response for a given region (e.g., structure or network) to determine whether TMS was effective in the relative engagement of the downstream targets. Both the sgACC and amygdala were differentially influenced by TMS. Furthermore, we found that the sgACC distributed brain network was modulated in response to fMRI-guided TMS. The amygdala, but not its distributed network, also responded to TMS. Our findings suggest that individual targeting and brain response measurements reflect causal circuit mapping to the sgACC and amygdala in humans. These results set the stage to further map circuits in the brain and link circuit pathway integrity to clinical intervention outcomes, especially when the intervention targets specific pathways and networks as is possible with TMS. LA - English DB - MTMT ER - TY - CHAP AU - Osborn, Luke E. AU - McMullen, David P. AU - Christie, Breanne P. AU - Kudela, Pawel AU - Thomas, Tessy M. AU - Thompson, Margaret C. AU - Nickl, Robert W. AU - Anaya, Manuel AU - Srihari, Sahana AU - Crone, Nathan E. AU - Wester, Brock A. AU - Celnik, Pablo A. AU - Cantarero, Gabriela L. AU - Tenore, Francesco V AU - Fifer, Matthew S. TI - Intracortical microstimulation of somatosensory cortex generates evoked responses in motor cortex T2 - 2021 10th International IEEE/EMBS Conference on Neural Engineering (NER) PB - IEEE CY - New York, New York CY - Piscataway (NJ) SN - 9781728143378 T3 - International IEEE EMBS Conference on Neural Engineering, ISSN 1948-3546 PY - 2021 SP - 53 EP - 56 PG - 4 DO - 10.1109/NER49283.2021.9441123 UR - https://m2.mtmt.hu/api/publication/32277266 ID - 32277266 N1 - Funding Agency and Grant Number: Defense Advanced Research Projects Agency (DARPA); Johns Hopkins University Applied Physics Laboratory (JHU/APL) Postdoctoral Fellowship Funding text: This research was developed with funding from the Defense Advanced Research Projects Agency (DARPA) and the Johns Hopkins University Applied Physics Laboratory (JHU/APL) Postdoctoral Fellowship. The views, opinions and/or findings expressed are those of the author and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. AB - The complex nature of neural connections throughout the cerebral cortex has led to broad interest in understanding cortical functional networks of tactile perception and sensorimotor integration. Cortico-cortical evoked potentials (CCEPs) can be used as physiological markers to study and map cerebral networks in the brain. In a human participant with bi-hemispheric microelectrode array implants in sensorimotor regions of the brain, we found that intracortical microstimulation (ICMS) of the primary somatosensory cortex can lead to evoked responses in the motor cortex in the same hemisphere, indicating connectivity between these sensorimotor regions. Single ICMS pulses were not consciously perceived, but elicited a rapid evoked potential approximately 20 ms after stimulus onset. Multi-pulse ICMS trains, perceived as tactile sensations in the thumb, sustained over an approximately 33 ms period, led to a delayed evoked response roughly 80 ms after stimulus onset. This work is important not only for better understanding the functional relationship between cortical areas, specifically somatosensory and motor cortices, but also to provide insight on pathways where neuromodulation techniques could be employed for rehabilitation or mitigation of sensorimotor neurodegenerative effects. LA - English DB - MTMT ER - TY - JOUR AU - Russo, S. AU - Pigorini, A. AU - Mikulan, E. AU - Sarasso, S. AU - Rubino, A. AU - Zauli, F.M. AU - Parmigiani, S. AU - d'Orio, P. AU - Cattani, A. AU - Francione, S. AU - Tassi, L. AU - Bassetti, C.L.A. AU - Lo, Russo G. AU - Nobili, L. AU - Sartori, I. AU - Massimini, M. TI - Focal lesions induce large-scale percolation of sleep-like intracerebral activity in awake humans JF - NEUROIMAGE J2 - NEUROIMAGE VL - 234 PY - 2021 SN - 1053-8119 DO - 10.1016/j.neuroimage.2021.117964 UR - https://m2.mtmt.hu/api/publication/32114098 ID - 32114098 N1 - Department of Biomedical and Clinical Sciences “L. Sacco”, University of Milan, Milan, Italy "C. Munari" Epilepsy Surgery Centre, Department of Neuroscience, Niguarda Hospital, Milan, 20162, Italy Institute of Neuroscience, CNR, via Volturno 39E, Parma, 43125, Italy Department of Psychiatry, University of Wisconsin, Madison, WI 53719, United States Child Neuropsychiatry, IRCCS Istituto G. Gaslini, Genova, 16147, Italy Department of Neurology, Inselspital, University of Bern, Switzerland Istituto Di Ricovero e Cura a Carattere Scientifico, Fondazione Don Carlo Gnocchi, Milan, 20148, Italy Azrieli Program in Brain, Mind and Consciousness, Canadian Institute for Advanced Research, Toronto, Canada Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy Export Date: 27 July 2021 CODEN: NEIME Correspondence Address: Massimini, M.; Department of Biomedical and Clinical Sciences “L. Sacco”, Italy; email: marcello.massimini@unimi.it LA - English DB - MTMT ER - TY - JOUR AU - Sala, Francesco AU - Giampiccolo, Davide AU - Cattaneo, Luigi TI - Novel Asleep Techniques for Intraoperative Assessment of Brain Connectivity JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 12 PY - 2021 PG - 5 SN - 1664-2295 DO - 10.3389/fneur.2021.687030 UR - https://m2.mtmt.hu/api/publication/32277268 ID - 32277268 N1 - Funding Agency and Grant Number: Fondazione Cassa di Risparmio di Verona Funding text: This work was supported by the grant NEUROCONNECT issued to FS by the Fondazione Cassa di Risparmio di Verona. LA - English DB - MTMT ER - TY - JOUR AU - Solomon, Ethan A. AU - Sperling, Michael R. AU - Sharan, Ashwini D. AU - Wanda, Paul A. AU - Levy, Deborah F. AU - Lyalenko, Anastasia AU - Pedisich, Isaac AU - Rizzuto, Daniel S. AU - Kahana, Michael J. TI - Theta-burst stimulation entrains frequency-specific oscillatory responses JF - BRAIN STIMULATION J2 - BRAIN STIMUL VL - 14 PY - 2021 IS - 5 SP - 1271 EP - 1284 PG - 14 SN - 1935-861X DO - 10.1016/j.brs.2021.08.014 UR - https://m2.mtmt.hu/api/publication/32277261 ID - 32277261 N1 - Funding Agency and Grant Number: Defense Advanced Research Projects Agency (DARPA) Restoring Active Memory program [N66001-14-2-4032]; NIH Grant U01 [NS113198] Funding text: We thank Blackrock Microsystems for providing neural recording equipment. This work was supported by the Defense Advanced Research Projects Agency (DARPA) Restoring Active Memory program (Cooperative Agreement N66001-14-2-4032) and NIH Grant U01 (NS113198) . We are indebted to all patients who have selflessly volunteered their time to participate in our study. The views, opinions, and/or findings contained in this material are those of the authors and should not be interpreted as representing the official views or policies of the Department of Defense or the US Government. We also thank Daniel Schonhaut, Dr. Daniel Rubin-stein, and Dr. Corey Keller for providing valuable feedback on this work. AB - Background: Brain stimulation has emerged as a powerful tool in human neuroscience, becoming integral to next-generation psychiatric and neurologic therapeutics. Theta-burst stimulation (TBS), in which electrical pulses are delivered in rhythmic bouts of 3-8 Hz, seeks to recapitulate neural activity seen endogenously during cognitive tasks. A growing literature suggests that TBS can be used to alter or enhance cognitive processes, but little is known about how these stimulation events influence underlying neural activity. Objective: Our study sought to investigate the effect of direct electrical TBS on mesoscale neural activity in humans by asking (1) whether TBS evokes persistent theta oscillations in cortical areas, (2) whether these oscillations occur at the stimulated frequency, and (3) whether stimulation events propagate in a manner consistent with underlying functional and structural brain architecture. Methods: We recruited 20 neurosurgical epilepsy patients with indwelling electrodes and delivered direct cortical TBS at varying locations and frequencies. Simultaneous iEEG was recorded from non stimulated electrodes and analyzed to understand how TBS influences mesoscale neural activity. Results: We found that TBS rapidly evoked theta rhythms in widespread brain regions, preferentially at the stimulation frequency, and that these oscillations persisted for hundreds of milliseconds post stimulation offset. Furthermore, the functional connectivity between recording and stimulation sites predicted the strength of theta response, suggesting that underlying brain architecture guides the flow of stimulation through the brain. Conclusions: By demonstrating that cortical TBS induces frequency-specific oscillatory responses, our results suggest this technology can be used to directly and predictably influence the activity of cognitively-relevant brain networks. (c) 2021 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). LA - English DB - MTMT ER - TY - JOUR AU - Sun, Kaijia AU - Wang, Haixiang AU - Bai, Yunxian AU - Zhou, Wenjing AU - Wang, Liang TI - MRIES: A Matlab Toolbox for Mapping the Responses to Intracranial Electrical Stimulation JF - FRONTIERS IN NEUROSCIENCE J2 - FRONT NEUROSCI-SWITZ VL - 15 PY - 2021 PG - 11 SN - 1662-4548 DO - 10.3389/fnins.2021.652841 UR - https://m2.mtmt.hu/api/publication/32277267 ID - 32277267 N1 - Funding Agency and Grant Number: National Natural Science Foundation of China [31771255, 32020103009]; CAS Interdisciplinary Innovation Team [JCTD-2018-07] Funding text: This study was supported by the National Natural Science Foundation of China (31771255 and 32020103009) and CAS Interdisciplinary Innovation Team (JCTD-2018-07). AB - Propose Directed cortical responses to intracranial electrical stimulation are a good standard for mapping inter-regional direct connectivity. Cortico-cortical evoked potential (CCEP), elicited by single pulse electrical stimulation (SPES), has been widely used to map the normal and abnormal brain effective network. However, automated processing of CCEP datasets and visualization of connectivity results remain challenging for researchers and clinicians. In this study, we develop a Matlab toolbox named MRIES (Mapping the Responses to Intracranial Electrical Stimulation) to automatically process CCEP data and visualize the connectivity results. Method The MRIES integrates the processing pipeline of the CCEP datasets and various methods for connectivity calculation based on low- and high-frequency signals with stimulation artifacts removed. The connectivity matrices are saved in different folders for visualization. Different visualization patterns (connectivity matrix, circle map, surface map, and volume map) are also integrated to the graphical user interface (GUI), which makes it easy to intuitively display and compare different connectivity measurements. Furthermore, one sample CCEP data set collected from eight epilepsy patients is used to validate the MRIES toolbox. Result We show the GUI and visualization functions of MRIES using one example CCEP data that has been described in a complete tutorial. We applied this toolbox to the sample CCEP data set to investigate the direct connectivity between the medial temporal lobe and the insular cortex. We find bidirectional connectivity between MTL and insular that are consistent with the findings of previous studies. Conclusion MRIES has a friendly GUI and integrates the full processing pipeline of CCEP data and various visualization methods. The MRIES toolbox, tutorial, and example data can be freely downloaded. As an open-source package, MRIES is expected to improve the reproducibility of CCEP findings and facilitate clinical translation. LA - English DB - MTMT ER - TY - JOUR AU - Veit, Mike J. AU - Kucyi, Aaron AU - Hu, Wenhan AU - Zhang, Chao AU - Zhao, Baotian AU - Guo, Zhihao AU - Yang, Bowen AU - Sava-Segal, Clara AU - Perry, Claire AU - Zhang, Jianguo AU - Zhang, Kai AU - Parvizi, Josef TI - Temporal order of signal propagation within and across intrinsic brain networks JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 118 PY - 2021 IS - 48 PG - 5 SN - 0027-8424 DO - 10.1073/pnas.2105031118 UR - https://m2.mtmt.hu/api/publication/32961416 ID - 32961416 N1 - Funding Agency and Grant Number: NIH [1R21NS113024]; National Natural Science Foundation of China [81771399, 81701276]; China Scholarship Council [201908110041]; Canadian Institutes of Health Research Funding text: We thank members of the Tiantan team for assistance with data collection. This work was supported by NIH research grant 1R21NS113024 (to J.P.); National Natural Science Foundation of China (Grants 81771399 and 81701276 to K.Z.); China Scholarship Council (Grant 201908110041 to C.Z.); and Banting Fellowship from the Canadian Institutes of Health Research (to A.K.). AB - We studied the temporal dynamics of activity within and across functional MRI (fMRI)-derived nodes of intrinsic resting-state networks of the human brain using intracranial electroencephalography (iEEG) and repeated single-pulse electrical stimulation (SPES) in neurosurgical subjects implanted with intracranial electrodes. We stimulated and recorded from 2,133 and 2,372 sites, respectively, in 29 subjects. We found that N1 and N2 segments of the evoked responses are associated with intra- and internetwork communications, respectively. In a separate cognitive experiment, evoked electrophysiological responses to visual target stimuli occurred with less temporal separation across pairs of electrodes that were located within the same fMRI-defined resting-state networks compared with those located across different resting-state networks. Our results suggest intranetwork prior to internetwork information processing at the subsecond timescale. LA - English DB - MTMT ER - TY - JOUR AU - Wang, Yujing AU - Hays, Mark A. AU - Coogan, Christopher AU - Kang, Joon Y. AU - Flinker, Adeen AU - Arya, Ravindra AU - Korzeniewska, Anna AU - Crone, Nathan E. TI - Spatial-Temporal Functional Mapping Combined With Cortico-Cortical Evoked Potentials in Predicting Cortical Stimulation Results JF - FRONTIERS IN HUMAN NEUROSCIENCE J2 - FRONT HUM NEUROSCI VL - 15 PY - 2021 PG - 13 SN - 1662-5161 DO - 10.3389/fnhum.2021.661976 UR - https://m2.mtmt.hu/api/publication/32277271 ID - 32277271 N1 - Funding Agency and Grant Number: National Institute of Neurological Disorders and Stroke [1R01NS115929, 1R01NS091139] Funding text: This research was supported by National Institute of Neurological Disorders and Stroke (1R01NS115929 and 1R01NS091139 to NC). AB - Functional human brain mapping is commonly performed during invasive monitoring with intracranial electroencephalographic (iEEG) electrodes prior to resective surgery for drug- resistant epilepsy. The current gold standard, electrocortical stimulation mapping (ESM), is time -consuming, sometimes elicits pain, and often induces after discharges or seizures. Moreover, there is a risk of overestimating eloquent areas due to propagation of the effects of stimulation to a broader network of language cortex. Passive iEEG spatial-temporal functional mapping (STFM) has recently emerged as a potential alternative to ESM. However, investigators have observed less correspondence between STFM and ESM maps of language than between their maps of motor function. We hypothesized that incongruities between ESM and STFM of language function may arise due to propagation of the effects of ESM to cortical areas having strong effective connectivity with the site of stimulation. We evaluated five patients who underwent invasive monitoring for seizure localization, whose language areas were identified using ESM. All patients performed a battery of language tasks during passive iEEG recordings. To estimate the effective connectivity of stimulation sites with a broader network of task-activated cortical sites, we measured cortico-cortical evoked potentials (CCEPs) elicited across all recording sites by single-pulse electrical stimulation at sites where ESM was performed at other times. With the combination of high gamma power as well as CCEPs results, we trained a logistic regression model to predict ESM results at individual electrode pairs. The average accuracy of the classifier using both STFM and CCEPs results combined was 87.7%, significantly higher than the one using STFM alone (71.8%), indicating that the correspondence between STFM and ESM results is greater when effective connectivity between ESM stimulation sites and task-activated sites is taken into consideration. These findings, though based on a small number of subjects to date, provide preliminary support for the hypothesis that incongruities between ESM and STFM may arise in part from propagation of stimulation effects to a broader network of cortical language sites activated by language tasks, and suggest that more studies, with larger numbers of patients, are needed to understand the utility of both mapping techniques in clinical practice. LA - English DB - MTMT ER - TY - JOUR AU - Zhang, Jiahe AU - Kucyi, Aaron AU - Raya, Jovicarole AU - Nielsen, Ashley N. AU - Nomi, Jason S. AU - Damoiseaux, Jessica S. AU - Greene, Deanna J. AU - Horovitz, Silvina G. AU - Uddin, Lucina Q. AU - Whitfield-Gabrieli, Susan TI - What have we really learned from functional connectivity in clinical populations? JF - NEUROIMAGE J2 - NEUROIMAGE VL - 242 PY - 2021 PG - 16 SN - 1053-8119 DO - 10.1016/j.neuroimage.2021.118466 UR - https://m2.mtmt.hu/api/publication/32277262 ID - 32277262 N1 - Funding Agency and Grant Number: NIMH [R01MH118217, R01MH107549, R03MH121668, R61/R33MH11375101A1, R01MH111448-01]; NINDS (Intramural Research Program); University of Miami (Gabelli Senior Scholar award); Brain and Behavior Research Foundation (NARSAD Young Investigator Award); Poitras Center for Psychiatric Disorders Research at Massachusetts Institute of Technology Funding text: This work was supported by the NIMH (R01MH118217 to DJG, R01MH107549 to LQU, R03MH121668 to JSN, R61/R33MH11375101A1 and R01MH111448-01 to SWG), the NINDS (Intramural Research Program to SGH), the University of Miami (Gabelli Senior Scholar award to LQU), the Brain and Behavior Research Foundation (NARSAD Young Investigator Award to JSN), and the Poitras Center for Psychiatric Disorders Research at Massachusetts Institute of Technology (to SWG). We thank the executive office of the Organization for Human Brain Mapping for providing information on annual meeting abstracts from the past five years. AB - Functional connectivity (FC), or the statistical interdependence of blood-oxygen dependent level (BOLD) signals between brain regions using fMRI, has emerged as a widely used tool for probing functional abnormalities in clinical populations due to the promise of the approach across conceptual, technical, and practical levels. With an already vast and steadily accumulating neuroimaging literature on neurodevelopmental, psychiatric, and neurological diseases and disorders in which FC is a primary measure, we aim here to provide a high-level synthesis of major concepts that have arisen from FC findings in a manner that cuts across different clinical conditions and sheds light on overarching principles. We highlight that FC has allowed us to discover the ubiquity of intrinsic functional networks across virtually all brains and clarify typical patterns of neurodevelopment over the lifespan. This understanding of typical FC maturation with age has provided important benchmarks against which to evaluate divergent maturation in early life and degeneration in late life. This in turn has led to the important insight that many clinical conditions are associated with complex, distributed, network-level changes in the brain, as opposed to solely focal abnormalities. We further emphasize the important role that FC studies have played in supporting a dimensional approach to studying transdiagnostic clinical symptoms and in enhancing the multimodal characterization and prediction of the trajectory of symptom progression across conditions. We highlight the unprecedented opportunity offered by FC to probe functional abnormalities in clinical conditions where brain function could not be easily studied otherwise, such as in disorders of consciousness. Lastly, we suggest high priority areas for future research and acknowledge critical barriers associated with the use of FC methods, particularly those related to artifact removal, data denoising and feasibility in clinical contexts. LA - English DB - MTMT ER - TY - JOUR AU - Fox, Kieran C. R. AU - Shi, Lin AU - Baek, Sori AU - Raccah, Omri AU - Foster, Brett L. AU - Saha, Srijani AU - Margulies, Daniel S. AU - Kucyi, Aaron AU - Parvizi, Josef TI - Intrinsic network architecture predicts the effects elicited by intracranial electrical stimulation of the human brain JF - NATURE HUMAN BEHAVIOUR J2 - NAT HUM BEHAV VL - e4 PY - 2020 IS - 10 SP - 1039 EP - 1060 PG - 22 SN - 2397-3374 DO - 10.1038/s41562-020-0910-1 UR - https://m2.mtmt.hu/api/publication/31422816 ID - 31422816 N1 - Funding Agency and Grant Number: Natural Sciences and Engineering Research Council (NSERC) of Canada; Stanford University School of Medicine; China Scholarship Council [201708110057]; National Natural Science Foundation of China [81701268]; National Institutes of Health [1P50MH109429, R00MH103479]; Banting Postdoctoral Fellowship from the Canadian Institutes of Health Research (CIHR) Funding text: The authors are grateful to the many patients who participated, without whom this research would have been impossible, as well as numerous funding agencies for generous support. K.C.R.F. was supported by a Postdoctoral Fellowship from the Natural Sciences and Engineering Research Council (NSERC) of Canada, and is currently supported by a Medical Scholars Research Fellowship from the Stanford University School of Medicine. L.S. is supported by the China Scholarship Council (201708110057) and National Natural Science Foundation of China (81701268). B.L.F. is supported by the National Institutes of Health (R00MH103479). A.K. was supported by a Banting Postdoctoral Fellowship from the Canadian Institutes of Health Research (CIHR). J.P. is supported by the National Institutes of Health (1P50MH109429). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. AB - Intracranial brain stimulation in humans elicits a large variety of perceptual, motor and cognitive effects. Fox et al. show strong links between the distribution and content of these responses and the brain's intrinsic network architecture.Intracranial electrical stimulation (iES) of the human brain has long been known to elicit a remarkable variety of perceptual, motor and cognitive effects, but the functional-anatomical basis of this heterogeneity remains poorly understood. We conducted a whole-brain mapping of iES-elicited effects, collecting first-person reports following iES at 1,537 cortical sites in 67 participants implanted with intracranial electrodes. We found that intrinsic network membership and the principal gradient of functional connectivity strongly predicted the type and frequency of iES-elicited effects in a given brain region. While iES in unimodal brain networks at the base of the cortical hierarchy elicited frequent and simple effects, effects became increasingly rare, heterogeneous and complex in heteromodal and transmodal networks higher in the hierarchy. Our study provides a comprehensive exploration of the relationship between the hierarchical organization of intrinsic functional networks and the causal modulation of human behaviour and experience with iES. LA - English DB - MTMT ER - TY - JOUR AU - Guo, Zhi-hao AU - Zhao, Bao-tian AU - Toprani, Sheela AU - Hu, Wen-han AU - Zhang, Chao AU - Wang, Xiu AU - Sang, Lin AU - Ma, Yan-shan AU - Shao, Xiao-qiu AU - Razavi, Babak AU - Parvizi, Josef AU - Fisher, Robert AU - Zhang, Jian-guo AU - Zhang, Kai TI - Epileptogenic network of focal epilepsies mapped with cortico-cortical evoked potentials JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 131 PY - 2020 IS - 11 SP - 2657 EP - 2666 PG - 10 SN - 1388-2457 DO - 10.1016/j.clinph.2020.08.012 UR - https://m2.mtmt.hu/api/publication/31689181 ID - 31689181 N1 - Funding Agency and Grant Number: National Natural Science Foundation of China [81771399, 81701276]; Beijing Municipal Science & Technology Commission [Z171100001017069]; Capital's Funds for Health Improvement and Research [2020-4-1076] Funding text: This study was supported by the National Natural Science Foundation of China (No. 81771399, 81701276), the Beijing Municipal Science & Technology Commission (Z171100001017069) and the Capital's Funds for Health Improvement and Research (2020-4-1076). AB - Objective: The goal of this study was to investigate the spatial extent and functional organization of the epileptogenic network through cortico-cortical evoked potentials (CCEPs) in patients being evaluated with intracranial stereoelectroencephalography.Methods: Weretrospectively included 25 patients. Wedivided the recorded sites into three regions: epileptogenic zone (EZ); propagation zone (PZ); and noninvolved zone (NIZ). The root mean square of the amplitudes was calculated to reconstruct effective connectivity network. Wealso analyzed the N1/N2 amplitudes to explore the responsiveness influenced by epileptogenicity. Prognostic analysis was performed by comparing intra-region and inter-region connectivity between seizure-free and non-seizure-free groups.Results: Our results confirmed that stimulation of the EZ caused the strongest responses on other sites within and outside the EZ. Moreover, wefound a hierarchical connectivity pattern showing the highest connectivity strength within EZ, and decreasing connectivity gradient from EZ, PZ to NIZ. Prognostic analysis indicated a stronger intra-EZ connection in the seizure-free group.Conclusion: The EZ showed highest excitability and dominantly influenced other regions. Quantitative CCEPs can be useful in mapping epileptic networks and predicting surgical outcome.Significance: The generated computational connectivity model may enhance our understanding of epileptogenic networks and provide useful information for surgical planning and prognosis prediction. (C) 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Inoue, Takeshi AU - Kobayashi, Katsuya AU - Matsumoto, Riki AU - Inouchi, Morito AU - Togo, Masaya AU - Togawa, Jumpei AU - Usami, Kiyohide AU - Shimotake, Akihiro AU - Matsuhashi, Masao AU - Kikuchi, Takayuki AU - Yoshida, Kazumichi AU - Kawawaki, Hisashi AU - Sawamoto, Nobukatsu AU - Kunieda, Takeharu AU - Miyamoto, Susumu AU - Takahashi, Ryosuke AU - Ikeda, Akio TI - Engagement of cortico-cortical and cortico-subcortical networks in a patient with epileptic spasms: An integrated neurophysiological study JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 131 PY - 2020 IS - 9 SP - 2255 EP - 2264 PG - 10 SN - 1388-2457 DO - 10.1016/j.clinph.2020.04.167 UR - https://m2.mtmt.hu/api/publication/31689184 ID - 31689184 N1 - Funding Agency and Grant Number: Japan Ministry of Education, Culture, Sports, Science and Technology (MEXT) KAKENHI [17H05907, 18H02709, 18K19514, 15H05874, 15H05875, 19H03574]; Japan Society for the Promotion of Science (JSPS) KAKENHI [17K16120]; Japan Epilepsy Research Foundation Funding text: We would like to thank Dr. H. Otsubo (Division of Neurology, The Hospital for Sick Children, Toronto, Canada) for his helpful advice on this manuscript. This work was supported by the Japan Ministry of Education, Culture, Sports, Science and Technology (MEXT) KAKENHI [grant numbers 17H05907, 18H02709, 18K19514, 15H05874, 15H05875 and 19H03574]; the Japan Society for the Promotion of Science (JSPS) KAKENHI [grant number 17K16120]; and a Research Grant from the Japan Epilepsy Research Foundation. AB - Objective: We aimed to delineate the engagement of cortico-cortical and cortico-subcortical networks in the generation of epileptic spasms (ES) using integrated neurophysiological techniques.Methods: Seventeen-year-old male patient with intractable ES underwent chronic subdural electrode implantation for presurgical evaluation. Networks were evaluated in ictal periods using high-frequency oscillation (HFO) analysis and in interictal periods using magnetoencephalography (MEG) and simultaneous electroencephalography, and functional magnetic resonance imaging (EEG-fMRI). Cortico-cortical evoked potentials (CCEPs) were recorded to trace connections among the networks.Results: Ictal HFO revealed a network comprising multilobar cortical regions (frontal, parietal, and temporal), but sparing the positive motor area. Interictally, MEG and EEG-fMRI revealed spike-and-wave-related activation in these cortical regions. Analysis of CCEPs provided evidence of connectivity within the cortico-cortical network. Additionally, EEG-fMRI results indicate the involvement of subcortical structures, such as bilateral thalamus (predominantly right) and midbrain.Conclusions: In this case study, integrated neurophysiological techniques provided converging evidence for the involvement of a cortico-cortical network (sparing the positive motor area) and a cortico-subcortical network in the generation of ES in the patient.Significance: Cortico-cortical and cortico-subcortical pathways, with the exception of the direct descending corticospinal pathway from the positive motor area, may play important roles in the generation of ES. (C) 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Ishida, Takuya AU - Dierks, Thomas AU - Strik, Werner AU - Morishima, Yosuke TI - Converging Resting State Networks Unravels Potential Remote Effects of Transcranial Magnetic Stimulation for Major Depression JF - FRONTIERS IN PSYCHIATRY J2 - FRONT PSYCHIATRY VL - 11 PY - 2020 PG - 13 SN - 1664-0640 DO - 10.3389/fpsyt.2020.00836 UR - https://m2.mtmt.hu/api/publication/31689179 ID - 31689179 N1 - Cited By :2 Export Date: 4 May 2022 Correspondence Address: Ishida, T.; Center for Evolutionary Cognitive Sciences, Japan; email: ishidafine@gmail.com Correspondence Address: Ishida, T.; Department of Neuropsychiatry, Kimiidera, Japan; email: ishidafine@gmail.com Correspondence Address: Ishida, T.; Division of Systems Neuroscience of Psychopathology, Switzerland; email: ishidafine@gmail.com AB - Despite being a commonly used protocol to treat major depressive disorder (MDD), the underlying mechanism of repetitive transcranial magnetic stimulation (rTMS) on dorsolateral prefrontal cortex (DLPFC) remains unclear. In the current study, we investigated the resting-state fMRI data of 100 healthy subjects by exploring three overlapping functional networks associated with the psychopathologically MDD-related areas (the nucleus accumbens, amygdala, and ventromedial prefrontal cortex). Our results showed that these networks converged at the bilateral DLPFC, which suggested that rTMS over DLPFC might improve MDD by remotely modulating the MDD-related areas synergistically. Additionally, they functionally converged at the DMPFC and bilateral insula which are known to be associated with MDD. These two areas could also be potential targets for rTMS treatment. Dynamic causal modelling (DCM) and Granger causality analysis (GCA) revealed that all pairwise connections among bilateral DLPFC, DMPFC, bilateral insula, and three psychopathologically MDD-related areas contained significant causality. The DCM results also suggested that most of the functional interactions between MDD-related areas and bilateral DLPFC, DMPFC, and bilateral insula can predominantly be explained by the effective connectivity from the psychopathologically MDD-related areas to the rTMS stimulation sites. Finally, we found the conventional functional connectivity to be a more representative measure to obtain connectivity parameters compared to GCA and DCM analysis. Our research helped inspecting the convergence of the functional networks related to a psychiatry disorder. The results identified potential targets for brain stimulation treatment and contributed to the optimization of patient-specific brain stimulation protocols. LA - English DB - MTMT ER - TY - JOUR AU - Kundu, Bornali AU - Davis, Tyler S. AU - Philip, Brian AU - Smith, Elliot H. AU - Arain, Amir AU - Peters, Angela AU - Newman, Blake AU - Butson, Christopher R. AU - Rolston, John D. TI - A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy JF - BRAIN STIMULATION J2 - BRAIN STIMUL VL - 13 PY - 2020 IS - 5 SP - 1232 EP - 1244 PG - 13 SN - 1935-861X DO - 10.1016/j.brs.2020.06.002 UR - https://m2.mtmt.hu/api/publication/31686218 ID - 31686218 N1 - Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, United States Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, United States Department of Neurology, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, United States Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, United States Cited By :6 Export Date: 21 October 2022 Correspondence Address: Rolston, J.D.; Department of Neurosurgery, 175 N. Medical Drive East, United States; email: neuropub@hsc.utah.edu Tradenames: SPM12 Manufacturers: Ad-Tech Medical, United States AB - Background: Brain activity is constrained by and evolves over a network of structural and functional connections. Corticocortical evoked potentials (CCEPs) have been used to measure this connectivity and to discern brain areas involved in both brain function and disease. However, how varying stimulation parameters influences the measured CCEP across brain areas has not been well characterized. Objective: To better understand the factors that influence the amplitude of the CCEPs as well as evoked gamma-band power (70-150 Hz) resulting from single-pulse stimulation via cortical surface and depth electrodes. Methods: CCEPs from 4370 stimulation-response channel pairs were recorded across a range of stimulation parameters and brain regions in 11 patients undergoing long-term monitoring for epilepsy. A generalized mixed-effects model was used to model cortical response amplitudes from 5 to 100 ms post-stimulation. Results: Stimulation levels <5.5 mA generated variable CCEPs with low amplitude and reduced spatial spread. Stimulation at >= 5.5 mA yielded a reliable and maximal CCEP across stimulation-response pairs over all regions. These findings were similar when examining the evoked gamma-band power. The amplitude of both measures was inversely correlated with distance. CCEPs and evoked gamma power were largest when measured in the hippocampus compared with other areas. Larger CCEP size and evoked gamma power were measured within the seizure onset zone compared with outside this zone.Conclusion: These results will help guide future stimulation protocols directed at quantifying network connectivity across cognitive and disease states. (C) 2020 The Authors. Published by Elsevier Inc. LA - English DB - MTMT ER - TY - JOUR AU - Lurie, Daniel J. AU - Kessler, Daniel AU - Bassett, Danielle S. AU - Betzel, Richard F. AU - Breakspear, Michael AU - Kheilholz, Shella AU - Kucyi, Aaron AU - Liegeois, Raphael AU - Lindquist, Martin A. AU - McIntosh, Anthony Randal AU - Poldrack, Russell A. AU - Shine, James M. AU - Thompson, William Hedley AU - Bielczyk, Natalia Z. AU - Douw, Linda AU - Kraft, Dominik AU - Miller, Robyn L. AU - Muthuraman, Muthuraman AU - Pasquini, Lorenzo AU - Razi, Adeel AU - Vidaurre, Diego AU - Xie, Hua AU - Calhoun, Vince D. TI - Questions and controversies in the study of time-varying functional connectivity in resting fMRI JF - NETWORK NEUROSCIENCE J2 - NETW NEUROSCI VL - 4 PY - 2020 IS - 1 SP - 30 EP - 69 PG - 40 SN - 2472-1751 DO - 10.1162/netn_a_00116 UR - https://m2.mtmt.hu/api/publication/31239980 ID - 31239980 N1 - Funding Agency and Grant Number: National Science FoundationNational Science Foundation (NSF) [1539067]; National Institute of Neurological Disorders and StrokeUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01 NS099348]; John D. and Catherine T. MacArthur Foundation; Alfred P. Sloan FoundationAlfred P. Sloan Foundation; Paul Allen Foundation [W911NF-10-2-0022]; Army Research Office [DCIST-W911NF-17-2-0181]; Office of Naval ResearchOffice of Naval Research; National Institute of Mental HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [R21-M MH-106799]; National Institute of Child Health and Human DevelopmentUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) [1R01HD086888-01]; Indiana University Office of the Vice President for Research; National Health and Medical Research CouncilNational Health and Medical Research Council of Australia [GNT1156536]; Australian Research CouncilAustralian Research Council [DE170100128]; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [P30GM122734]; Canadian Institutes of Health ResearchCanadian Institutes of Health Research (CIHR); Banting Fellowship [IVAN 20CH21 174081]; National Institute of Biomedical Imaging and BioengineeringUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) [R01 EB026549]; AliceWallenberg FoundationKnut & Alice Wallenberg Foundation [2016.0473]; Society in Science, Award ID: Branco Weiss Fellowship; Dutch Organization for Scientific ResearchNetherlands Organization for Scientific Research (NWO) [016.146.086]; Dominik Kraft, German Research Foundation [INST 247/859-1]; German Research FoundationGerman Research Foundation (DFG) [SFB CRC-TR-128] Funding text: Daniel J. Lurie, National Science Foundation, Award ID: DGE 1106400. Daniel J. Lurie, National Institute of Neurological Disorders and Stroke, Award ID: 1F31NS108665-01A1. Daniel Kessler, National Science Foundation, Award ID: DMS-1646108. Danielle S. Bassett, John D. and Catherine T. MacArthur Foundation. Danielle S. Bassett, Alfred P. Sloan Foundation. Danielle S. Bassett, ISI Foundation. Danielle S. Bassett, Paul Allen Foundation. Danielle S. Bassett, Army Research Laboratory, Award ID: W911NF-10-2-0022. Danielle S. Bassett, Army Research Office, Award ID: Bassett-W911NF-14-1-0679. Danielle S. Bassett, Army Research Office, Award ID: Grafton-W911NF-16-1-0474. Danielle S. Bassett, Army Research Office, Award ID: DCIST-W911NF-17-2-0181. Danielle S. Bassett, Office of Naval Research. Danielle S. Bassett, National Institute of Mental Health, Award ID: 2-R01-DC-009209-11. Danielle S. Bassett, National Institute of Mental Health, Award ID: R01-MH112847. Danielle S. Bassett, National Institute of Mental Health, Award ID: R01-MH107235. Danielle S. Bassett, National Institute of Mental Health, Award ID: R21-M MH-106799. Danielle S. Bassett, National Institute of Child Health and Human Development, Award ID: 1R01HD086888-01. Danielle S. Bassett, National Institute of Neurological Disorders and Stroke, Award ID: R01 NS099348. Danielle S. Bassett, National Science Foundation, Award ID: BCS-1441502. Danielle S. Bassett, National Science Foundation, Award ID: BCS-1430087. Danielle S. Bassett, National Science Foundation, Award ID: NSF PHY-1554488. Danielle S. Bassett, National Science Foundation, Award ID: BCS-1631550. Richard F. Betzel, Indiana University Office of the Vice President for Research, Award ID: Emerging Area of Research Initiative, Learning: Brains, Machines, and Children. Michael Breakspear, National Health and Medical Research Council, Award ID: 118153. Michael Breakspear, National Health and Medical Research Council, Award ID: 10371296. Michael Breakspear, National Health and Medical Research Council, Award ID: 1095227. Michael Breakspear, Australian Research Council, Award ID: CE140100007. Shell Kielholz, National Institutes of Health, Award ID: R01MH111416. Shell Kielholz, National Institutes of Health, Award ID: R01NS078095. Shell Kielholz, National Science Foundation, Award ID: BCS INSPIRE 1533260. Aaron Kucyi, Canadian Institutes of Health Research, Award ID: Banting Fellowship. Raphael Liegeois, CHIST-ERA (http://dx.doi.org/10.13039/501100001942), Award ID: IVAN 20CH21 174081. Martin A. Lindquist, National Institute of Biomedical Imaging and Bioengineering, Award ID: R01 EB016061. Martin A. Lindquist, National Institute of Biomedical Imaging and Bioengineering, Award ID: R01 EB026549. James M. Shine, National Health and Medical Research Council, Award ID: GNT1072403. James M. Shine, National Health and Medical Research Council, Award ID: GNT1156536. William Hedley Thompson, Knut and AliceWallenberg Foundation, Award ID: 2016.0473. LindaDouw, Society in Science, Award ID: Branco Weiss Fellowship. Linda Douw, Dutch Organization for Scientific Research, Award ID: 016.146.086. Adeel Razi, Australian Research Council, Award ID: DECRA, DE170100128. Dominik Kraft, German Research Foundation, Award ID: CRC 1193. Dominik Kraft, German Research Foundation, Award ID: INST 247/859-1. Muthuraman Muthuraman, German Research Foundation, Award ID: SFB CRC-1193. Muthuraman Muthuraman, German Research Foundation, Award ID: SFB CRC-TR-128. Vince D. Calhoun, National Institutes of Health, Award ID: R01EB020407. Vince D.; Calhoun, National Institutes of Health, Award ID: P20GM103472. Vince D. Calhoun, National Institutes of Health, Award ID: P30GM122734. Vince D. Calhoun, National Science Foundation, Award ID: 1539067. LA - English DB - MTMT ER - TY - JOUR AU - Nakae, Takuro AU - Matsumoto, Riki AU - Kunieda, Takeharu AU - Arakawa, Yoshiki AU - Kobayashi, Katsuya AU - Shimotake, Akihiro AU - Yamao, Yukihiro AU - Kikuchi, Takayuki AU - Aso, Toshihiko AU - Matsuhashi, Masao AU - Yoshida, Kazumichi AU - Ikeda, Akio AU - Takahashi, Ryosuke AU - Ralph, Matthew A. Lambon AU - Miyamoto, Susumu TI - Connectivity Gradient in the Human Left Inferior Frontal Gyrus: Intraoperative Cortico-Cortical Evoked Potential Study JF - CEREBRAL CORTEX J2 - CEREB CORTEX VL - 30 PY - 2020 IS - 8 SP - 4633 EP - 4650 PG - 18 SN - 1047-3211 DO - 10.1093/cercor/bhaa065 UR - https://m2.mtmt.hu/api/publication/31685308 ID - 31685308 N1 - Funding Agency and Grant Number: Ministry of Education, Culture, Sports, Science, and Technology [15H05874, 17H05907]; Japan Society for the Promotion of Science [17K10892, 18H02709, 18K19514, 19K17033, 19K18424]; Medical Research Council, UK [MR/R023883/1]; MRC [MR/R023883/1] Funding Source: UKRI Funding text: Ministry of Education, Culture, Sports, Science, and Technology (grant numbers 15H05874, 17H05907); Japan Society for the Promotion of Science (grant numbers 17K10892, 18H02709, 18K19514, 19K17033, 19K18424); Medical Research Council, UK (MR/R023883/1 to M.A.L.R.). AB - In the dual-stream model of language processing, the exact connectivity of the ventral stream to the anterior temporal lobe remains elusive. To investigate the connectivity between the inferior frontal gyrus (IFG) and the lateral part of the temporal and parietal lobes, we integrated spatiotemporal profiles of cortico-cortical evoked potentials (CCEPs) recorded intraoperatively in 14 patients who had undergone surgical resection for a brain tumor or epileptic focus. Four-dimensional visualization of the combined CCEP data showed that the pars opercularis (Broca's area) is connected to the posterior temporal cortices and the supramarginal gyrus, whereas the pars orbitalis is connected to the anterior lateral temporal cortices and angular gyrus. Quantitative topographical analysis of CCEP connectivity confirmed an anterior-posterior gradient of connectivity from IFG stimulus sites to the temporal response sites. Reciprocality analysis indicated that the anterior part of the IFG is bidirectionally connected to the temporal or parietal area. This study shows that each IFG subdivision has different connectivity to the temporal lobe with an anterior-posterior gradient and supports the classical connectivity concept of Dejerine; that is, the frontal lobe is connected to the temporal lobe through the arcuate fasciculus and also a double fan-shaped structure anchored at the limen insulae. LA - English DB - MTMT ER - TY - JOUR AU - Novitskaya, Y. AU - Dümpelmann, M. AU - Vlachos, A. AU - Reinacher, P.C. AU - Schulze-Bonhage, A. TI - In vivo-assessment of the human temporal network: Evidence for asymmetrical effective connectivity JF - NEUROIMAGE J2 - NEUROIMAGE VL - 214 PY - 2020 SN - 1053-8119 DO - 10.1016/j.neuroimage.2020.116769 UR - https://m2.mtmt.hu/api/publication/31295717 ID - 31295717 N1 - Epilepsy Center, Department of Neurosurgery, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, Freiburg, 79106, Germany Department of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, Albert Strasse 17, Freiburg, 79104, Germany Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, Freiburg, 79106, Germany Center for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, Freiburg, 79106, Germany Export Date: 30 April 2020 CODEN: NEIME Correspondence Address: Novitskaya, Y.; Epilepsy Center, Department of Neurosurgery, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, Germany; email: yuliya.novitskaya@gmail.com Funding details: Albert-Ludwigs-Universität Freiburg Funding text 1: This research was supported by the Human Brain Project (Grant: 650003 : Medical informatics platform for stereoelectroencephalography SEEGMIP). The article processing charge was funded by the University of Freiburg in the funding programme Open Access Publishing. LA - English DB - MTMT ER - TY - JOUR AU - Prime, David AU - Woolfe, Matthew AU - Rowlands, David AU - O'Keefe, Steven AU - Dionisio, Sasha TI - Comparing connectivity metrics in cortico-cortical evoked potentials using synthetic cortical response patterns JF - JOURNAL OF NEUROSCIENCE METHODS J2 - J NEUROSCI METH VL - 334 PY - 2020 PG - 15 SN - 0165-0270 DO - 10.1016/j.jneumeth.2019.108559 UR - https://m2.mtmt.hu/api/publication/31422817 ID - 31422817 AB - Background: Cortico-Cortical Evoked Potentials (CCEPs) are a novel low frequency stimulation method used for brain mapping during intracranial epilepsy investigations. Only a handful of metrics have been applied to CCEP data to infer connectivity, and no comparison as to which is best has been performed.New method: We implement a novel method which involved superimposing synthetic cortical responses onto stereoelectroencephalographic (SEEG) data, and use this to compare several metric's ability to detect the simulated patterns. In this we compare two commonly employed metrics currently used in CCEP analysis against eight time series similarity metrics (TSSMs), which have been widely used in machine learning and pattern matching applications.Results: Root Mean Square (RMS), a metric commonly employed in CCEP analysis, was sensitive to a wide variety of response patterns, but insensitive to simulated epileptiform patterns. Autoregressive (AR) coefficients calculated by Burg's method were also sensitive to a wide range of patterns, but were extremely sensitive to epileptiform patterns. Other metrics which employed elastic warping techniques were less sensitive to the simulated response patterns. Comparison with existing methods: Our study is the first to compare CCEP connectivity metrics against one-another. Our results found that RMS, which has been used in many CCEP studies previously, was the most sensitive metric across a wide range of patterns.Conclusions: Our novel method showed that RMS is a robust and sensitive measure, validating much of the findings of the SEEG-CCEP literature to date. Autoregressive coefficients may also be a useful metric to investigate epileptic networks. LA - English DB - MTMT ER - TY - JOUR AU - Qiao, Shaoyu AU - Sedillo, J. Isaac AU - Brown, Kevin A. AU - Ferrentino, Breonna AU - Pesaran, Bijan TI - A Causal Network Analysis of Neuromodulation in the Mood Processing Network JF - NEURON J2 - NEURON VL - 107 PY - 2020 IS - 5 SP - 972 EP - + PG - 20 SN - 0896-6273 DO - 10.1016/j.neuron.2020.06.012 UR - https://m2.mtmt.hu/api/publication/31689183 ID - 31689183 N1 - Funding Agency and Grant Number: Defense Advanced Research Projects Agency (DARPA) [W911NF-14-2-0043]; Simons Collaboration on the Global Brain; National Institutes of Health (NIH) BRAIN grant [R01-NS104923] Funding text: We would like to thank Baldwin Goodell, Charles Gray, Jessica Kleinbart, and Amy Orsborn for assistance with chamber and microdrive system design; Stephen Frey and Brian Hynes for custom modifications to the Brainsight system; Keith Sanzenbach and Pablo Velasco from the NYU Center for Imaging for help with magnetic resonance imaging and diffusion weighted imaging; and Ryan Shewcraft, John Choi, Marsela Rubiano, Yoohee Jang, Octavia Martin, and the NYU Office of Veterinary Resources for help with animal preparation and care. This work was supported in part by the Defense Advanced Research Projects Agency (DARPA) under Cooperative Agreement W911NF-14-2-0043, issued by the Army Research Office contracting office in support of DARPA's SUBNETS program (to B.P.). The views, opinions, and/or findings expressed are those of the author(s) and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. This work was also supported in part by an award from the Simons Collaboration on the Global Brain (to B.P.) and National Institutes of Health (NIH) BRAIN grant R01-NS104923 (to B.P.). AB - Neural decoding and neuromodulation technologies hold great promise for treating mood and other brain disorders in next-generation therapies that manipulate functional brain networks. Here we perform a novel causal network analysis to decode multiregional communication in the primate mood processing network and determine how neuromodulation, short-burst tetanic microstimulation (sbTetMS), alters multiregional network communication. The causal network analysis revealed a mechanism of network excitability that regulates when a sender stimulation site communicates with receiver sites. Decoding network excitability from neural activity at modulator sites predicted sender-receiver communication, whereas sbTetMS neuromodulation temporarily disrupted sender-receiver communication. These results reveal specific network mechanisms of multiregional communication and suggest a new generation of brain therapies that combine neural decoding to predict multiregional communication with neuromodulation to disrupt multiregional communication. LA - English DB - MTMT ER - TY - JOUR AU - Shibata, Sumiya AU - Yamao, Yukihiro AU - Kunieda, Takeharu AU - Inano, Rika AU - Nakae, Takuro AU - Nishida, Sei AU - Inada, Taku AU - Takahashi, Yuki AU - Kikuchi, Takayuki AU - Arakawa, Yoshiki AU - Yoshida, Kazumichi AU - Matsumoto, Riki AU - Ikeda, Akio AU - Mima, Tatsuya AU - Miyamoto, Susumu TI - Intraoperative Electrophysiologic Mapping of Medial Frontal Motor Areas and Functional Outcomes JF - WORLD NEUROSURGERY J2 - WORLD NEUROSURG VL - 138 PY - 2020 SP - E389 EP - E404 PG - 16 SN - 1878-8750 DO - 10.1016/j.wneu.2020.02.129 UR - https://m2.mtmt.hu/api/publication/31422815 ID - 31422815 N1 - Funding Agency and Grant Number: Japan Society for the Promotion of Science [15H05880, 17K10892, 19H01091, 19K18424, 19K24329]; Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine; GlaxoSmithKline K.K.; Nihon Kohden Corporation; Otsuka Pharmaceutical; UCB Japan Co. Ltd. Funding text: This work was partly supported by Grants-in-Aid for Scientific Research (KAKENHI) (grant nos. 15H05880 [T.M.], 17K10892 [T.Ki.], 19H01091 [T.M.], 19K18424 [Y.Y.], 19K24329 [S.S.]) from the Japan Society for the Promotion of Science. The Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine is an endowment department, supported with grants by GlaxoSmithKline K.K., Nihon Kohden Corporation, Otsuka Pharmaceutical, and UCB Japan Co. Ltd. LA - English DB - MTMT ER - TY - JOUR AU - Vincent, M. A. AU - Bonnetblanc, F. AU - Mandonnet, E. AU - Boyer, A. AU - Duffau, H. AU - Guiraud, D. TI - Measuring the electrophysiological effects of direct electrical stimulation after awake brain surgery JF - JOURNAL OF NEURAL ENGINEERING J2 - J NEURAL ENG VL - 17 PY - 2020 IS - 1 PG - 25 SN - 1741-2560 DO - 10.1088/1741-2552/ab5cdd UR - https://m2.mtmt.hu/api/publication/31422819 ID - 31422819 AB - Objective. Direct electrical stimulation (DES) at 60 Hz is used to perform real-time functional mapping of the brain, and guide tumour resection during awake neurosurgery. Nonetheless, the electrophysiological effects of DES remain largely unknown, both locally and remotely. Approach. In this study, we lowered the DES frequency to 1-10 Hz and we used a differential recording mode of electro-corticographic (ECoG) signals to improve the focality with a simple algorithm to remove the artefacts due to the response of the acquisition chain. Main results. Doing so, we were able to observe different components in the evoked potentials triggered by simulating the cortex or the subcortical white matter pathways near the recording electrodes and by stimulating the cortex remotely from the recording site. More particularly, P0 and N1 components were repeatedly observed on raw ECoG signals without the need to average the data. Significance. This new methodology is important to probe the electrophysiological states and the connectivity of the brain in vivo and in real time, namely to perform electrophysiological brain mapping on human patients operated in the neurosurgical room and to better understand the electrophysiological spreading of DES. LA - English DB - MTMT ER - TY - JOUR AU - Crowther, Lawrence J. AU - Brunner, Peter AU - Kapeller, Christoph AU - Guger, Christoph AU - Kamada, Kyousuke AU - Bunch, Marjorie E. AU - Frawley, Bridget K. AU - Lynch, Timothy M. AU - Ritaccio, Anthony L. AU - Schalk, Gerwin TI - A quantitative method for evaluating cortical responses to electrical stimulation JF - JOURNAL OF NEUROSCIENCE METHODS J2 - J NEUROSCI METH VL - 311 PY - 2019 SP - 67 EP - 75 PG - 9 SN - 0165-0270 DO - 10.1016/j.jneumeth.2018.09.034 UR - https://m2.mtmt.hu/api/publication/30388857 ID - 30388857 N1 - National Center for Adaptive Neurotechnologies, Wadsworth Center, New York State Department of Health, Albany, NY, United States Department of Neurology, Albany Medical College, Albany, NY, United States g.tec Guger Technologies OG, Graz, Austria Department of Neurosurgery, Asahikawa Medical University, Asahikawa, Japan Department of Biomedical Sciences, State University of New York at Albany, Albany, NY, United States Department of Neurology, Mayo Clinic, Jacksonville, FL, United States Cited By :8 Export Date: 18 August 2020 CODEN: JNMED Correspondence Address: Schalk, G.; National Center for Adaptive Neurotechnologies, Wadsworth Center, New York State Department of HealthUnited States; email: gschalk@neurotechcenter.org AB - Background: Electrical stimulation of the cortex using subdurally implanted electrodes can causally reveal structural connectivity by eliciting cortico-cortical evoked potentials (CCEPs). While many studies have demonstrated the potential value of CCEPs, the methods to evaluate them were often relatively subjective, did not consider potential artifacts, and did not lend themselves to systematic scientific investigations. LA - English DB - MTMT ER - TY - JOUR AU - Etkin, Amit AU - Maron-Katz, Adi AU - Wu, Wei AU - Fonzo, Gregory A. AU - Huemer, Julia AU - Vertes, Petra E. AU - Patenaude, Brian AU - Richiardi, Jonas AU - Goodkind, Madeleine S. AU - Keller, Corey J. AU - Ramos-Cejudo, Jaime AU - Zaiko, Yevgeniya AU - Peng, Kathy K. AU - Shpigel, Emmanuel AU - Longwell, Parker AU - Toll, Russ T. AU - Thompson, Allison AU - Zack, Sanno AU - Gonzalez, Bryan AU - Edelstein, Raleigh AU - Chen, Jingyun AU - Akingbade, Irene AU - Weiss, Elizabeth AU - Hart, Roland AU - Mann, Silas AU - Durkin, Kathleen AU - Baete, Steven H. AU - Boada, Fernando E. AU - Genfi, Afia AU - Autea, Jillian AU - Newman, Jennifer AU - Oathes, Desmond J. AU - Lindley, Steven E. AU - Abu-Amara, Duna AU - Arnow, Bruce A. AU - Crossley, Nicolas AU - Hallmayer, Joachim AU - Fossati, Silvia AU - Rothbaum, Barbara O. AU - Marmar, Charles R. AU - Bullmore, Edward T. AU - O'Hara, Ruth TI - Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder JF - SCIENCE TRANSLATIONAL MEDICINE J2 - SCI TRANSL MED VL - 11 PY - 2019 IS - 486 PG - 12 SN - 1946-6234 DO - 10.1126/scitranslmed.aal3236 UR - https://m2.mtmt.hu/api/publication/31021979 ID - 31021979 N1 - Funding Agency and Grant Number: National Institute of Mental Health [R01 MH091860]; Steven A. and Alexandra M. Cohen Foundation; Cohen Veterans Bioscience; Sierra-Pacific Mental Illness Research, Education, and Clinical Center of the Palo Alto Veterans Affairs Health Care System; National Key Research and Development Plan of China [2017YFB1002505]; NIMH [T32 MH019938]; Office of Academic Affiliations, Advanced Fellowship Program in Mental Illness Research and Treatment, Department of Veterans Affairs; UK Medical Research Council [MR/K020706/1]; EPSRC [EP/N510129/1]; MRC [MR/K020706/1] Funding Source: UKRI; NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [P41EB017183] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF MENTAL HEALTH [T32MH019938] Funding Source: NIH RePORTER Funding text: This work was funded by R01 MH091860 from the National Institute of Mental Health (to A.E.), a grant from the Steven A. and Alexandra M. Cohen Foundation to NYU School of Medicine (to C.R.M.), and funds from Cohen Veterans Bioscience and Ann and Peter Tarlton (to A.E.). A.E. and R.O. were also funded by the Sierra-Pacific Mental Illness Research, Education, and Clinical Center of the Palo Alto Veterans Affairs Health Care System. W.W. was funded by the National Key Research and Development Plan of China (grant 2017YFB1002505). G.A.F. was supported by NIMH grant T32 MH019938 and the Office of Academic Affiliations, Advanced Fellowship Program in Mental Illness Research and Treatment, Department of Veterans Affairs. P.E.V. was supported by the UK Medical Research Council (grant MR/K020706/1) and is a Fellow of MQ: Transforming Mental Health (MQF17_24) and of the Alan Turing Institute funded by EPSRC grant EP/N510129/1. AB - A mechanistic understanding of the pathology of psychiatric disorders has been hampered by extensive heterogeneity in biology, symptoms, and behavior within diagnostic categories that are defined subjectively. We investigated whether leveraging individual differences in information-processing impairments in patients with post-traumatic stress disorder (PTSD) could reveal phenotypes within the disorder. We found that a subgroup of patients with PTSD from two independent cohorts displayed both aberrant functional connectivity within the ventral attention network (VAN) as revealed by functional magnetic resonance imaging (fMRI) neuroimaging and impaired verbal memory on a word list learning task. This combined phenotype was not associated with differences in symptoms or comorbidities, but nonetheless could be used to predict a poor response to psychotherapy, the best-validated treatment for PTSD. Using concurrent focal noninvasive transcranial magnetic stimulation and electroencephalography, we then identified alterations in neural signal flow in the VAN that were evoked by direct stimulation of that network. These alterations were associated with individual differences in functional fMRI connectivity within the VAN. Our findings define specific neurobiological mechanisms in a subgroup of patients with PTSD that could contribute to the poor response to psychotherapy. LA - English DB - MTMT ER - TY - JOUR AU - Fan, Zhen AU - Chen, Xiao AU - Qi, Zeng-Xin AU - Li, Le AU - Liu, Bin AU - Jiang, Cong-Lin AU - Zhu, Ren-Qing AU - Yan, Chao-Gan AU - Chen, Liang TI - Physiological significance of R-fMRI indices: Can functional metrics differentiate structural lesions (brain tumors)? JF - NEUROIMAGE-CLINICAL J2 - NEUROIMAGE-CLIN VL - 22 PY - 2019 PG - 10 SN - 2213-1582 DO - 10.1016/j.nicl.2019.101741 UR - https://m2.mtmt.hu/api/publication/31021977 ID - 31021977 N1 - Funding Agency and Grant Number: Natural Science Foundation and Major Basic Research Program of Shanghai [16JC1420100]; "Shuguang Program" of Shanghai Education Development Foundation and Shanghai Municipal Education Commission [16SG02]; Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]; Shanghai Municipal Health Commission Intelligence Medical Program [2018ZHYL0107]; Shanghai Municipal Health Commission Subject Chief Scientist; National Key R&D Program of China [2017YFC1309902]; National Natural Science Foundation of China [81671774, 81630031]; Hundred Talents Program and the 13th Five-year Informatization Plan of Chinese Academy of Sciences [XXH13505]; Beijing Municipal Science & Technology Commission [Z161100000216152] Funding text: The authors thank the reviewers for their careful work and constructive comments, Zhong Yang for assembling the image database. This work was supported by the Natural Science Foundation and Major Basic Research Program of Shanghai (16JC1420100); "Shuguang Program" of Shanghai Education Development Foundation and Shanghai Municipal Education Commission (16SG02); Shanghai Municipal Science and Technology Major Project (2018SHZDZX01); Shanghai Municipal Health Commission Intelligence Medical Program (2018ZHYL0107); Shanghai Municipal Health Commission Subject Chief Scientist (2018); National Key R&D Program of China (2017YFC1309902); The National Natural Science Foundation of China (81671774 and 81630031); the Hundred Talents Program and the 13th Five-year Informatization Plan (XXH13505) of Chinese Academy of Sciences; Beijing Municipal Science & Technology Commission (Z161100000216152). AB - Resting-state functional MRI (R-fMRI) research has recently entered the era of "big data", however, few studies have provided a rigorous validation of the physiological underpinnings of R-fMRI indices. Although studies have reported that various neuropsychiatric disorders exhibit abnormalities in R-fMRI measures, these "biomarkers" have not been validated in differentiating structural lesions (brain tumors) as a concept proof. We enrolled 60 patients with intracranial tumors located in the unilateral cranial cavity and 60 matched normal controls to test whether R-fMRI indices can differentiate tumors, which represents a prerequisite for adapting such indices as biomarkers for neuropsychiatric disorders. Common R-fMRI indices of tumors and their counterpart control regions, which were defined as the contralateral normal areas (for amplitude of low frequency fluctuations (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo) and degree centrality (DC)) and ipsilateral regions surrounding the tumors (for voxel-mirrored homotopic connectivity (VMHC)), were comprehensively assessed. According to robust paired t-tests with a Bonferroni correction, only VMHC (Fisher's r-to-z transformed) could successfully differentiate substantial tumors from their counterpart normal regions in patients. Furthermore, ALFF and DC were not able to differentiate tumor from normal unless Z-standardization was employed. To validate the lower power of the between-subject design compared to the within-subject design, each metric was calculated in a matched control group, and robust two-sample t-tests were used to compare the patient tumors and the normal controls at the same place. Similarly, only VMHC succeeded in differentiating significant differences between tumors and the sham tumor areas of normal controls. This study tested the premise of R-fMRI biomarkers for differentiating lesions, and brings a new understanding to physical significance of the Z-standardization. LA - English DB - MTMT ER - TY - JOUR AU - Hebbink, Jurgen AU - van Blooijs, Dorien AU - Huiskamp, Geertjan AU - Leijten, Frans S. S. AU - van Gils, Stephan A. AU - Meijer, Hil G. E. TI - A Comparison of Evoked and Non-evoked Functional Networks JF - BRAIN TOPOGRAPHY J2 - BRAIN TOPOGR VL - 32 PY - 2019 IS - 3 SP - 405 EP - 417 PG - 13 SN - 0896-0267 DO - 10.1007/s10548-018-0692-1 UR - https://m2.mtmt.hu/api/publication/31021978 ID - 31021978 N1 - Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, Netherlands Department of Applied Mathematics, MIRA Institute for Biomedical Engineering and Technical Medicine, University of Twente, Drienerlolaan 5, Enschede, 7500 AE, Netherlands Cited By :7 Export Date: 18 August 2020 CODEN: BRTOE Correspondence Address: Hebbink, J.; Department of Applied Mathematics, MIRA Institute for Biomedical Engineering and Technical Medicine, University of Twente, Drienerlolaan 5, Netherlands; email: g.j.hebbink@utwente.nl AB - The growing interest in brain networks to study the brain's function in cognition and diseases has produced an increase in methods to extract these networks. Typically, each method yields a different network. Therefore, one may ask what the resulting networks represent. To address this issue we consider electrocorticography (ECoG) data where we compare three methods. We derive networks from on-going ECoG data using two traditional methods: cross-correlation (CC) and Granger causality (GC). Next, connectivity is probed actively using single pulse electrical stimulation (SPES). We compare the overlap in connectivity between these three methods as well as their ability to reveal well-known anatomical connections in the language circuit. We find that strong connections in the CC network form more or less a subset of the SPES network. GC and SPES are related more weakly, although GC connections coincide more frequently with SPES connections compared to non-existing SPES connections. Connectivity between the two major hubs in the language circuit, Broca's and Wernicke's area, is only found in SPES networks. Our results are of interest for the use of patient-specific networks obtained from ECoG. In epilepsy research, such networks form the basis for methods that predict the effect of epilepsy surgery. For this application SPES networks are interesting as they disclose more physiological connections compared to CC and GC networks. LA - English DB - MTMT ER - TY - JOUR AU - Huang, Yuhao AU - Hajnal, Boglárka Zsófia AU - Entz, László AU - Fabó, Dániel AU - Herrero, Jose L. AU - Mehta, Ashesh D. AU - Keller, Corey J. TI - Intracortical Dynamics Underlying Repetitive Stimulation Predicts Changes in Network Connectivity JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 39 PY - 2019 IS - 31 SP - 6122 EP - 6135 PG - 14 SN - 0270-6474 DO - 10.1523/JNEUROSCI.0535-19.2019 UR - https://m2.mtmt.hu/api/publication/31020318 ID - 31020318 N1 - Funding Agency and Grant Number: National Institute of Neurological Disorders and Stroke [F31NS080357-01, T32-GM007288]; Stanford Society of Physician Scholars Collaborative Research Fellowship; Alpha Omega Alpha Postgraduate Research Award; Hungarian National Research, Development, and Innovation Office [2017-1.2.1-NKP-2017-00002]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007288] Funding Source: NIH RePORTER Funding text: This work was supported by the National Institute of Neurological Disorders and Stroke (F31NS080357-01 and T32-GM007288), Stanford Society of Physician Scholars Collaborative Research Fellowship, and Alpha Omega Alpha Postgraduate Research Award to C.J.K., and by the Hungarian National Research, Development, and Innovation Office (2017-1.2.1-NKP-2017-00002) to D.F. We thank Maria Fini and Victor Du for help with data collection, Pierre Megevand and Erin Yeagle for help with technical considerations of the experimental design, and Wei Wu for comments on the paper. All authors discussed the data, analysis, and methods and contributed to the paper. The authors are enormously indebted to the patients who participated in this study, as well as the nursing and physician staff at North Shore University Hospital (Manhassat, NY) and the National Institute of Clinical Neurosciences (Budapest, Hungary). AB - Targeted stimulation can be used to modulate the activity of brain networks. Previously we demonstrated that direct electrical stimulation produces predictable poststimulation changes in brain excitability. However, understanding the neural dynamics during stimulation and its relationship to poststimulation effects is limited but critical for treatment optimization. Here, we applied 10 Hz direct electrical stimulation across several cortical regions in 14 human subjects (6 males) implanted with intracranial electrodes for seizure monitoring. The stimulation train was characterized by a consistent increase in high gamma (70 -170 Hz) power. Immediately post-train, low-frequency (1-8 Hz) power increased, resulting in an evoked response that was highly correlated with the neural response during stimulation. Using two measures of network connectivity, corticocortical evoked potentials (indexing effective connectivity), and theta coherence (indexing functional connectivity), we found a stronger response to stimulation in regions that were highly connected to the stimulation site. In these regions, repeated cycles of stimulation trains and rest progressively altered the stimulation response. Finally, after just 2 min (similar to 10%) of repetitive stimulation, we were able to predict poststimulation connectivity changes with high disc rim inability. Together, this work reveals a relationship between stimulation dynamics and poststimulation connectivity changes in humans. Thus, measuring neural activity during stimulation can inform future plasticity-inducing protocols. LA - English DB - MTMT ER - TY - JOUR AU - Lehner, Kurt R. AU - Yeagle, Erin M. AU - Argyelan, Miklos AU - Klimaj, Zoltan AU - Du, Victor AU - Megevand, Pierre AU - Hwang, Sean T. AU - Mehta, Ashesh D. TI - Validation of corpus callosotomy after laser interstitial thermal therapy: a multimodal approach JF - JOURNAL OF NEUROSURGERY J2 - J NEUROSURG VL - 131 PY - 2019 IS - 4 SP - 1095 EP - 1105 PG - 11 SN - 0022-3085 DO - 10.3171/2018.4.JNS172588 UR - https://m2.mtmt.hu/api/publication/31021974 ID - 31021974 N1 - Department of Neurosurgery, Hofstra Northwell School of Medicine, United States Feinstein Institute for Medical Research, United States Department of Neurology, North Shore University Hospital, Manhasset, NY, United States Cited By :5 Export Date: 18 August 2020 CODEN: JONSA Correspondence Address: Mehta, A.D.; Hofstra Northwell School of Medicine, Feinstein Institute for Medical ResearchUnited States; email: amehta@northwell.edu AB - OBJECTIVE Disconnection of the cerebral hemispheres by corpus callosotomy (CC) is an established means to palliate refractory generalized epilepsy. Laser interstitial thermal therapy (LITT) is gaining acceptance as a minimally invasive approach to treating epilepsy, but this method has not been evaluated in clinical series using established methodologies to assess connectivity. The goal in this study was to demonstrate the safety and feasibility of MRI-guided LITT for CC and to assess disconnection by using electrophysiology- and imaging-based methods.METHODS Retrospective chart and imaging review was performed in 5 patients undergoing LITT callosotomy at a single center. Diffusion tensor imaging and resting functional MRI were performed in all patients to assess anatomical and functional connectivity. In 3 patients undergoing simultaneous intracranial electroencephalography monitoring, corticocortical evoked potentials and resting electrocorticography were used to assess electrophysiological correlates.RESULTS All patients had generalized or multifocal seizure onsets. Three patients with preoperative evidence for possible lateralization underwent stereoelectroencephalography depth electrode implantation during the perioperative period. LITT ablation of the anterior corpus callosum was completed in a single procedure in 4 patients. One complication involving misplaced devices required a second procedure. Adequacy of the anterior callosotomy was confirmed using contrast-enhanced MRI and diffusion tensor imaging. Resting functional MRI, corticocortical evoked potentials, and resting electrocorticography demonstrated functional disconnection of the hemispheres. Postcallosotomy monitoring revealed lateralization of the seizures in all 3 patients with preoperatively suspected occult lateralization. Four of 5 patients experienced > 80% reduction in generalized seizure frequency. Two patients undergoing subsequent focal resection are free of clinical seizures at 2 years. One patient developed a 9-mm intraparenchymal hematoma at the site of entry and continued to have seizures after the procedure.CONCLUSIONS MRI-guided LITT provides an effective minimally invasive alternative method for CC in the treatment of seizures associated with drop attacks, bilaterally synchronous onset, and rapid secondary generalization. The disconnection is confirmed using anatomical and functional neuroimaging and electrophysiological measures. LA - English DB - MTMT ER - TY - JOUR AU - Paunov, Alexander M. AU - Blank, Idan A. AU - Fedorenko, Evelina TI - Functionally distinct language and Theory of Mind networks are synchronized at rest and during language comprehension JF - JOURNAL OF NEUROPHYSIOLOGY J2 - J NEUROPHYSIOL VL - 121 PY - 2019 IS - 4 SP - 1244 EP - 1265 PG - 22 SN - 0022-3077 DO - 10.1152/jn.00619.2018 UR - https://m2.mtmt.hu/api/publication/33255265 ID - 33255265 N1 - Funding Agency and Grant Number: Simons Foundation; NIH [R00-HD057522, R01-DC016607] Funding text: This work was supported by a grant from the Simons Foundation to the Simons Center for the Social Brain at MIT. E. Fedorenko was additionally supported by NIH awards R00-HD057522 and R01-DC016607. AB - Communication requires the abilities to generate and interpret utterances and to infer the beliefs, desires, and goals of others ("Theory of Mind"; ToM). These two abilities have been shown to dissociate: individuals with aphasia retain the ability to think about others' mental states; and individuals with autism are impaired in social reasoning, but their basic language processing is often intact. In line with this evidence from brain disorders, functional MRI (fMRI) studies have shown that linguistic and ToM abilities recruit distinct sets of brain regions. And yet, language is a social tool that allows us to share thoughts with one another. Thus, the language and ToM brain networks must share information despite being implemented in distinct neural circuits. Here, we investigated potential interactions between these networks during naturalistic cognition using functional correlations in fMRI. The networks were functionally defined in individual participants, in terms of preference for sentences over nonwords for language, and for belief inference over physical-event processing for ToM, with both a verbal and a nonverbal paradigm. Although, across experiments, interregion correlations within each network were higher than between-network correlations, we also observed above-baseline synchronization of blood oxygenation level-dependent signal fluctuations between the two networks during rest and story comprehension. This synchronization was functionally specific: neither network was synchronized with the executive control network (functionally defined in terms of preference for a harder over easier version of an executive task). Thus, coordination between the language and ToM networks appears to be an inherent and specific characteristic of their functional architecture. NEW & NOTEWORTHY Humans differ from nonhuman primates in their abilities to communicate linguistically and to infer others' mental states. Although linguistic and social abilities appear to be interlinked onto- and phylogenetically, they are dissociated in the adult human brain. Yet successful communication requires language and social reasoning to work in concert. Using functional MRI, we show that language regions are synchronized with social regions during rest and language comprehension, pointing to a possible mechanism for internetwork interaction. LA - English DB - MTMT ER - TY - JOUR AU - Suzuki, Yuto AU - Enatsu, Rei AU - Kanno, Aya AU - Yokoyama, Rintaro AU - Suzuki, Hime AU - Tachibana, Shunsuke AU - Akiyama, Yukinori AU - Mikami, Takeshi AU - Ochi, Satoko AU - Yamakage, Michiaki AU - Mikuni, Nobuhiro TI - The Influence of Anesthesia on Corticocortical Evoked Potential Monitoring Network Between Frontal and Temporoparietal Cortices JF - WORLD NEUROSURGERY J2 - WORLD NEUROSURG VL - 123 PY - 2019 SP - E685 EP - E692 PG - 8 SN - 1878-8750 DO - 10.1016/j.wneu.2018.11.253 UR - https://m2.mtmt.hu/api/publication/31021980 ID - 31021980 N1 - Funding Agency and Grant Number: KAKENHI [16K10795]; Japan Ministry of Education, Culture, Sports, Science and Technology (MEXT) Funding text: This study was partly supported by KAKENHI 16K10795 from the Japan Ministry of Education, Culture, Sports, Science and Technology (MEXT). AB - BACKGROUND: Previous studies have reported the usefulness of intraoperative corticocortical evoked potentials (CCEPs) for preserving language function during brain surgery.OBJECTIVE: This study aimed to assess the influence of depth of anesthesia on CCEP to establish its clinical utility.METHODS: Twenty patients with brain tumors or epilepsy who underwent awake craniotomy were included in this study. Before resection, the electrode plates were placed on the frontal and temporoparietal cortices, and 1-Hz alternating electrical stimuli were delivered to the pars opercularis/pars triangularis in a bipolar fashion. Electrocorticograms from the temporoparietal cortices time-locked to stimuli were averaged to obtain CCEP responses from a state of deep anesthesia until the awake state. The correlation between CCEP waveforms and bispectral index (BIS) was evaluated.RESULTS: CCEP amplitude increased with the increase in the BIS level. CCEP latency decreased in 5 patients and increased in 15 patients under anesthesia compared with the awake state. CCEP amplitudes decreased by 11.3% to 75.2% (median 31.3%) under anesthesia with <65 BIS level. These differences were statistically significant (P < 0.01, Wilcoxon signed-rank test). With respect to CCEP latencies, there was no significant difference between the awake and anesthetic states.CONCLUSIONS: CCEP amplitudes were correlated with depth of anesthesia, whereas CCEP latencies were not affected by anesthesia. The influence of anesthesia should be considered when applying this technique to intraoperative monitoring. LA - English DB - MTMT ER - TY - JOUR AU - Takeyama, Hirofumi AU - Matsumoto, Riki AU - Usami, Kiyohide AU - Nakae, Takuro AU - Kobayashi, Katsuya AU - Shimotake, Akihiro AU - Kikuchi, Takayuki AU - Yoshida, Kazumichi AU - Kunieda, Takeharu AU - Miyamoto, Susumu AU - Takahashi, Ryosuke AU - Ikeda, Akio TI - Human entorhinal cortex electrical stimulation evoked short-latency potentials in the broad neocortical regions: Evidence from cortico-cortical evoked potential recordings JF - BRAIN AND BEHAVIOR J2 - BRAIN BEHAV VL - 9 PY - 2019 IS - 9 PG - 13 SN - 2162-3279 DO - 10.1002/brb3.1366 UR - https://m2.mtmt.hu/api/publication/31021976 ID - 31021976 N1 - Funding Agency and Grant Number: Japan Science and Technology Agency [15H05874, 17H05907, 18H02709, 18K19514, 19K17004] Funding text: Japan Science and Technology Agency, Grant/Award Number: 15H05874, 17H05907, 18H02709, 18K19514 and 19K17004 AB - Objective We aimed at clarifying the clinical significance of the responses evoked by human entorhinal cortex (EC) electrical stimulation by means of cortico-cortical evoked potentials (CCEPs). Methods We enrolled nine patients with medically intractable medial temporal lobe epilepsy who underwent invasive presurgical evaluations with subdural or depth electrodes. Single-pulse electrical stimulation was delivered to the EC and fusiform gyrus (FG), and their evoked potentials were compared. The correlation between the evoked potentials and Wechsler Memory Scale-Revised (WMS-R) score was analyzed to investigate whether memory circuit was involved in the generation of the evoked potentials. Results In most electrodes placed on the neocortex, EC stimulation induced unique evoked potentials with positive polarity, termed as "widespread P1" (P1w). Compared with FG stimulation, P1w induced by EC stimulation were distinguished by their high occurrence rate, short peak latency (mean: 20.1 ms), small peak amplitude, and waveform uniformity among different recording sites. A stimulation of more posterior parts of the EC induced P1w with shorter latency and larger amplitude. P1w peak amplitude had a positive correlation (r = .69) with the visual memory score of the WMS-R. In one patient, with depth electrode implanted into the hippocampus, the giant evoked potentials were recorded in the electrodes of the anterior hippocampus and EC near the stimulus site. Conclusions The human EC electrical stimulation evoked the short-latency potentials in the broad neocortical regions. The origin of P1w remains unclear, although the limited evidence suggests that P1w is the far-field potential by the volume conduction of giant evoked potential from the EC itself and hippocampus. The significance of the present study is that those evoked potentials may be a potential biomarker of memory impairment in various neurological diseases, and we provided direct evidence for the functional subdivisions along the anterior-posterior axis in the human EC. LA - English DB - MTMT ER - TY - JOUR AU - Usami, Kiyohide AU - Milsap, Griffin W. AU - Korzeniewska, Anna AU - Collard, Maxwell J. AU - Wang, Yujing AU - Lesser, Ronald P. AU - Anderson, William S. AU - Crone, Nathan E. TI - Cortical Responses to Input From Distant Areas are Modulated by Local Spontaneous Alpha/Beta Oscillations JF - CEREBRAL CORTEX J2 - CEREB CORTEX VL - 29 PY - 2019 IS - 2 SP - 777 EP - 787 PG - 11 SN - 1047-3211 DO - 10.1093/cercor/bhx361 UR - https://m2.mtmt.hu/api/publication/31021981 ID - 31021981 N1 - Department of Neurology, Johns Hopkins University, School of Medicine, 600N. Wolfe St., Baltimore, MD 21287, United States Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, United States Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, United States Department of Neurosurgery, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, United States Cited By :4 Export Date: 18 August 2020 CODEN: CECOE Correspondence Address: Crone, N.E.; Department of Neurology, Johns Hopkins University, School of Medicine, 600N. Wolfe St., United States; email: ncrone@jhmi.edu AB - Any given area in human cortex may receive input from multiple, functionally heterogeneous areas, potentially representing different processing threads. Alpha (8-13 Hz) and beta oscillations (13-20 Hz) have been hypothesized by other investigators to gate local cortical processing, but their influence on cortical responses to input from other cortical areas is unknown. To study this, we measured the effect of local oscillatory power and phase on cortical responses elicited by single-pulse electrical stimulation (SPES) at distant cortical sites, in awake human subjects implanted with intracranial electrodes for epilepsy surgery. In 4 out of 5 subjects, the amplitudes of corticocortical evoked potentials (CCEPs) elicited by distant SPES were reproducibly modulated by the power, but not the phase, of local oscillations in alpha and beta frequencies. Specifically, CCEP amplitudes were higher when average oscillatory power just before distant SPES (-110 to -10 ms) was high. This effect was observed in only a subset (0-33%) of sites with CCEPs and, like the CCEPs themselves, varied with stimulation at different distant sites. Our results suggest that although alpha and beta oscillations may gate local processing, they may also enhance the responsiveness of cortex to input from distant cortical sites. LA - English DB - MTMT ER - TY - JOUR AU - Usami, Kiyohide AU - Korzeniewska, Anna AU - Matsumoto, Riki AU - Kobayashi, Katsuya AU - Hitomi, Takefumi AU - Matsuhashi, Masao AU - Kunieda, Takeharu AU - Mikuni, Nobuhiro AU - Kikuchi, Takayuki AU - Yoshida, Kazumichi AU - Miyamoto, Susumu AU - Takahashi, Ryosuke AU - Ikeda, Akio AU - Crone, Nathan E. TI - The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation JF - SLEEP J2 - SLEEP VL - 42 PY - 2019 IS - 6 PG - 9 SN - 0161-8105 DO - 10.1093/sleep/zsz050 UR - https://m2.mtmt.hu/api/publication/31021975 ID - 31021975 N1 - Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States Department of Neurology, Kyoto University, Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan Department of Clinical Laboratory Medicine, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto, Japan Department of Respiratory Care and Sleep Control Medicine, Kyoto University, Graduate School of Medicine, Sakyoku, Kyoto, Japan Research and Educational Unit of Leaders for Integrated Medical System, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto, Japan Human Brain Research Center, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto, Japan Department of Neurosurgery, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto, Japan Department of Neurosurgery, Ehime University, Graduate School of Medicine, Shizukawa Toon city, Ehime, Japan Department of Neurosurgery, Sapporo Medical University, Chuo-ku, Sapporo, Japan Department of Epilepsy, Movement Disorders and Physiology, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto, Japan Cited By :5 Export Date: 18 August 2020 CODEN: SLEED Correspondence Address: Usami, K.; Department of Neurology, Kyoto University, Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Japan; email: ukiyo@kuhp.kyoto-u.ac.jp AB - Wakefulness and sleep arise from global changes in brain physiology that may also govern the flow of neural activity between cortical regions responsible for perceptual processing versus planning and action. To test whether and how the sleep/wake cycle affects the overall propagation of neural activity in large-scale brain networks, we applied single-pulse electrical stimulation (SPES) in patients implanted with intracranial EEG electrodes for epilepsy surgery. SPES elicited cortico-cortical spectral responses at high-gamma frequencies (CCSRHG, 80-150 Hz), which indexes changes in neuronal population firing rates. Using event-related causality (ERC) analysis, we found that the overall patterns of neural propagation among sites with CCSRHG were different during wakefulness and different sleep stages. For example, stimulation of frontal lobe elicited greater propagation toward parietal lobe during slow-wave sleep than during wakefulness. During REM sleep, we observed a decrease in propagation within frontal lobe, and an increase in propagation within parietal lobe, elicited by frontal and parietal stimulation, respectively. These biases in the directionality of large-scale cortical network dynamics during REM sleep could potentially account for some of the unique experiential aspects of this sleep stage. Together these findings suggest that the regulation of conscious awareness and sleep is associated with differences in the balance of neural propagation across large-scale frontal-parietal networks. LA - English DB - MTMT ER - TY - JOUR AU - Ezzyat, Youssef AU - Rizzuto, Daniel S. TI - Direct brain stimulation during episodic memory JF - CURRENT OPINION IN BIOMEDICAL ENGINEERING J2 - CURR OPIN BIOMED ENG VL - 8 PY - 2018 SP - 78 EP - 83 PG - 6 SN - 2468-4511 DO - 10.1016/j.cobme.2018.11.004 UR - https://m2.mtmt.hu/api/publication/33255266 ID - 33255266 N1 - Funding Agency and Grant Number: Swarthmore College faculty research fund; DARPA Restoring Active Memory (RAM) program [N66001-14-2-4032] Funding text: This work was supported by the Swarthmore College faculty research fund and the DARPA Restoring Active Memory (RAM) program (Cooperative Agreement N66001-14-2-4032). The views, opinions, and/or findings contained in this material are those of the authors and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. AB - The success of direct brain stimulation as a treatment for neurological disorders such as Parkinson's Disease has led to increased interest in developing stimulation-based therapeutic applications for other cognitive domains, such as learning and memory. Here, we review recent advances in using stimulation for memory modulation and enhancement in humans. An expanded set of stimulation targets have been studied that can modulate broad memory networks and behavioral performance. Using online neural decoding during memory processing, closed-loop systems have been used to deliver stimulation with greater precision and improve behavioral outcomes. The data suggest strategies for future therapeutic applications to treating memory dysfunction. LA - English DB - MTMT ER - TY - JOUR AU - Fox, Kieran C R AU - Foster, Brett L AU - Kucyi, Aaron AU - Daitch, Amy L AU - Parvizi, Josef TI - Intracranial Electrophysiology of the Human Default Network JF - TRENDS IN COGNITIVE SCIENCES J2 - TRENDS COGN SCI VL - 22 PY - 2018 IS - 4 SP - 307 EP - 324 PG - 18 SN - 1364-6613 DO - 10.1016/j.tics.2018.02.002 UR - https://m2.mtmt.hu/api/publication/27302990 ID - 27302990 N1 - Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States Stanford Human Intracranial Cognitive Electrophysiology Program (SHICEP), Stanford, CA, United States Departments of Neurosurgery and Neuroscience, Baylor College of Medicine, Houston, TX, United States Stanford University School of Medicine, Stanford University, Stanford, CA, United States Cited By :21 Export Date: 18 August 2020 CODEN: TCSCF Correspondence Address: Fox, K.C.R.; Stanford Human Intracranial Cognitive Electrophysiology Program (SHICEP)United States; email: kcrfox@stanford.edu LA - English DB - MTMT ER - TY - JOUR AU - Hawco, Colin AU - Voineskos, Aristotle N. AU - Steeves, Jennifer K. E. AU - Dickie, Erin W. AU - Viviano, Joseph D. AU - Downar, Jonathan AU - Blumberger, Daniel M. AU - Daskalakis, Zafiris J. TI - Spread of activity following TMS is related to intrinsic resting connectivity to the salience network: A concurrent TMS-fMRI study JF - CORTEX: A JOURNAL DEVOTED TO THE STUDY OF THE NERVOUS SYSTEM AND BEHAVIOR J2 - CORTEX VL - 108 PY - 2018 SP - 160 EP - 172 PG - 13 SN - 0010-9452 DO - 10.1016/j.cortex.2018.07.010 UR - https://m2.mtmt.hu/api/publication/30387630 ID - 30387630 N1 - Funding Agency and Grant Number: Natural Sciences and Engineering Research Council (NSERC) of Canada; Banting Post-Doctoral Fellowship from the Canadian Institute of Health Research Funding text: This study was supported by a Discovery Grant from the Natural Sciences and Engineering Research Council (NSERC) of Canada. The authors declare no competing financial interests. Dr. Hawco was supported by a Banting Post-Doctoral Fellowship from the Canadian Institute of Health Research during part of this work. AB - Transcranial magnetic stimulation (TMS) modulates activity at local and regions distal to the site of simulation. TMS has also been found to modulate brain networks, and it has been hypothesized that functional connectivity may predict the neuronal changes at local and distal sites in response to a TMS pulse. However, a direct relationship between resting connectivity and change in TMS-induced brain activation has yet to be demonstrated. Concurrent TMS-fMRI is a technique to directly measure this spread activity following TMS in real time. In twenty-two participants, resting-state fMRI scans were acquired, followed by four ten minute sessions of concurrent TMS-fMRI over the left dorsolateral prefrontal cortex (DLPFC). Seed-based functional connectivity to the individualized TMS target was examined using the baseline resting fMRI scan data, and the change of activity resulting from TMS was determined using a general linear model (High vs Low intensity TMS). While at the group level the spatial pattern of resting connectivity related to the pattern of TMS-induced cortical changes, there was substantial variability across individuals. This variability was further probed by examining individuals connectivity from the TMS target to six resting state networks. Only connectivity between the salience network (SN) and the TMS target site correlated with the RSC-TMS score. This suggests that resting state connectivity is correlated with TMS-induced changes in activity following DLPFC stimulation, particularly when the DLPFC target interacts with the SN. These results highlight the importance of examining such relationships at the individual level and may help to guide individual treatment in clinical populations. (C) 2018 Elsevier Ltd. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Keller, Corey J AU - Huang, Yuhao AU - Herrero, Jose L AU - Fini, Maria E AU - Du, Victor AU - Lado, Fred A AU - Honey, Christopher J AU - Mehta, Ashesh D TI - Induction and Quantification of Excitability Changes in Human Cortical Networks JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 38 PY - 2018 IS - 23 SP - S384 EP - S398 PG - 15 SN - 0270-6474 DO - 10.1523/JNEUROSCI.1088-17.2018 UR - https://m2.mtmt.hu/api/publication/27555163 ID - 27555163 N1 - Department of Neurosurgery, Feinstein Institute for Medical Research, Manhasset, NY 11030, United States Department of Neurology, Hofstra Northwell School of Medicine, Feinstein Institute for Medical Research, Manhasset, NY 11030, United States Department of Psychiatry and Behavioral Sciences, Stanford, CA 94305, United States Stanford Neuroscience Institute, Stanford University, Stanford, CA 94305, United States Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA 94394, United States Departments of Neuroscience and Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, United States Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, United States Cited By :14 Export Date: 18 August 2020 CODEN: JNRSD Correspondence Address: Keller, C.J.; Stanford University, 401 Quarry Road, United States; email: ckeller1@stanford.edu LA - English DB - MTMT ER - TY - JOUR AU - Muller, Leah AU - Rolston, John D AU - Fox, Neal P AU - Knowlton, Robert AU - Rao, Vikram R AU - Chang, Edward F TI - Direct electrical stimulation of human cortex evokes high gamma activity that predicts conscious somatosensory perception JF - JOURNAL OF NEURAL ENGINEERING J2 - J NEURAL ENG VL - 15 PY - 2018 IS - 2 PG - 10 SN - 1741-2560 DO - 10.1088/1741-2552/aa9bf9 UR - https://m2.mtmt.hu/api/publication/27302953 ID - 27302953 N1 - Funding Agency and Grant Number: NIH [U01NS098971, R01-DC012379, F32-DC013953, F32-DC015966]; New York Stem Cell Foundation; McKnight Foundation; Shurl and Kay Curci Foundation; William K Bowes Foundation; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007618] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [U01NS098971] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC012379, F32DC015966, F32DC013953] Funding Source: NIH RePORTER Funding text: The authors would like to thank Dr Joseph O'Doherty for helpful discussion. This work was supported by grants from the NIH (U01NS098971 and R01-DC012379 to EFC, F32-DC013953 to JDR, F32-DC015966 to NPF). EFC is a New York Stem Cell Foundation-Robertson Investigator. This research was also supported by The New York Stem Cell Foundation, The McKnight Foundation, The Shurl and Kay Curci Foundation, and The William K Bowes Foundation. LA - English DB - MTMT ER - TY - JOUR AU - Prime, David AU - Rowlands, David AU - O'Keefe, Steven AU - Dionisio, Sasha TI - Considerations in performing and analyzing the responses of cortico-cortical evoked potentials in stereo-EEG JF - EPILEPSIA J2 - EPILEPSIA VL - 59 PY - 2018 IS - 1 SP - 16 EP - 26 PG - 11 SN - 0013-9580 DO - 10.1111/epi.13939 UR - https://m2.mtmt.hu/api/publication/27302994 ID - 27302994 LA - English DB - MTMT ER - TY - JOUR AU - Solomon, E. A. AU - Kragel, J. E. AU - Gross, R. AU - Lega, B. AU - Sperling, M. R. AU - Worrell, G. AU - Sheth, S. A. AU - Zaghloul, K. A. AU - Jobst, B. C. AU - Stein, J. M. AU - Das, S. AU - Gorniak, R. AU - Inman, C. S. AU - Seger, S. AU - Rizzuto, D. S. AU - Kahana, M. J. TI - Medial temporal lobe functional connectivity predicts stimulation-induced theta power JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 9 PY - 2018 PG - 13 SN - 2041-1723 DO - 10.1038/s41467-018-06876-w UR - https://m2.mtmt.hu/api/publication/30387631 ID - 30387631 N1 - Funding Agency and Grant Number: DARPA Restoring Active Memory (RAM) program [N66001-14-2-4032]; National Institutes of Health [MH55687, T32NS091006]; 16 NIH Institutes and Centers [1U54MH091657]; McDonnell Center for Systems Neuroscience at Washington University; NATIONAL INSTITUTE OF MENTAL HEALTH [R29MH055687, R01MH055687, U54MH091657] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [T32NS091006, ZIANS003144] Funding Source: NIH RePORTER Funding text: We thank Blackrock Microsystems for providing neural recording equipment. This work was supported by the DARPA Restoring Active Memory (RAM) program (Cooperative Agreement N66001-14-2-4032), as well as National Institutes of Health grant MH55687 and T32NS091006. We are indebted to all patients who have selflessly volunteered their time to participate in our study. The views, opinions, and/or findings contained in this material are those of the authors and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. We also thank Drs. Youssef Ezzyat, Christoph Weidemann, Nora Herweg, Danielle Bassett, and Geoffrey Aguirre for providing valuable feedback on this work. Data were provided in part by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University. AB - Focal electrical stimulation of the brain incites a cascade of neural activity that propagates from the stimulated region to both nearby and remote areas, offering the potential to control the activity of brain networks. Understanding how exogenous electrical signals perturb such networks in humans is key to its clinical translation. To investigate this, we applied electrical stimulation to subregions of the medial temporal lobe in 26 neurosurgical patients fitted with indwelling electrodes. Networks of low-frequency (5-13 Hz) spectral coherence predicted stimulation-evoked increases in theta (5-8 Hz) power, particularly when stimulation was applied in or adjacent to white matter. Stimulation tended to decrease power in the high-frequency broadband (HFB; 50-200 Hz) range, and these modulations were correlated with HFB-based networks in a subset of subjects. Our results demonstrate that functional connectivity is predictive of causal changes in the brain, capturing evoked activity across brain regions and frequency bands. LA - English DB - MTMT ER - TY - JOUR AU - Trebaul, Lena AU - Deman, Pierre AU - Tuyisenge, Viateur AU - Jedynak, Maciej AU - Hugues, Etienne AU - Rudrauf, David AU - Bhattacharjee, Manik AU - Tadel, Francois AU - Chanteloup-Foret, Blandine AU - Saubat, Carole AU - Mejia, Gina Catalina Reyes AU - Adam, Claude AU - Nica, Anca AU - Pail, Martin AU - Dubeau, Francois AU - Rheims, Sylvain AU - Trebuchon, Agnes AU - Wang, Haixiang AU - Liu, Sinclair AU - Blauwblomme, Thomas AU - Garces, Mercedes AU - De Palma, Luca AU - Valentin, Antonio AU - Metsahonkala, Eeva-Liisa AU - Petrescu, Ana Maria AU - Landre, Elizabeth AU - Szurhaj, William AU - Hirsch, Edouard AU - Valton, Luc AU - Rocamora, Rodrigo AU - Schulze-Bonhage, Andreas AU - Mindruta, Ioana AU - Francione, Stefano AU - Maillard, Louis AU - Taussig, Delphine AU - Kahane, Philippe AU - David, Olivier TI - Probabilistic functional tractography of the human cortex revisited JF - NEUROIMAGE J2 - NEUROIMAGE VL - 181 PY - 2018 SP - 414 EP - 429 PG - 16 SN - 1053-8119 DO - 10.1016/j.neuroimage.2018.07.039 UR - https://m2.mtmt.hu/api/publication/30387610 ID - 30387610 N1 - Inserm, U1216, Grenoble, F-38000, France Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, F-38000, France Epilepsy Unit, Dept of Neurology, Pitié-Salpêtrière Hospital, APHP, Paris, France Neurology Department, CHU, Rennes, France Brno Epilepsy Center, Department of Neurology, St. Anne's University Hospital and Medical Faculty of Masaryk University, Brno, Czech Republic Montreal Neurological Institute and Hospital, Montreal, Canada Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and University of Lyon, Lyon, France Service de Neurophysiologie Clinique, APHM, Hôpitaux de la Timone, Marseille, France Yuquan Hospital Epilepsy Center, Tsinghua University, Beijing, China Canton Sanjiu Brain Hospital Epilepsy Center, Jinan University, Guangzhou, China Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, Université Paris V Descartes, Sorbonne Paris Cité, Paris, France Multidisciplinary Epilepsy Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain Department of Neuroscience, Bambino Gesù Children's Hospital, IRRCS, Rome, Italy Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), London, United Kingdom Epilepsy Unit, Hospital for Children and Adolescents, Helsinki, Finland Neurophysiology and Epilepsy Unit, Bicêtre Hospital, France Department of Neurosurgery, Sainte-Anne Hospital, Paris, France Epilepsy Unit, Department of Clinical Neurophysiology, Lille University Medical Center, Lille, France University Hospital, Department of Neurology, Strasbourg, France University Hospital, Department of Neurology, Toulouse, France Epilepsy Monitoring Unit, Department of Neurology, Hospital del Mar-IMIM, Barcelona, Spain Epilepsy Center, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany Neurology Department, University Emergency Hospital, Bucharest, Romania Epilepsy Surgery Center Niguarda Hospital, Milan, Italy Centre Hospitalier Universitaire de Nancy, Nancy, France Service de neurochirurgie pédiatrique, Fondation Rothschild, Paris, France CHU Grenoble Alpes, Neurology Department, Grenoble, France Cited By :16 Export Date: 18 August 2020 CODEN: NEIME Correspondence Address: David, O.; Grenoble Institut des Neurosciences, Chemin Fortuné Ferrini, Bât EJ Safra, France; email: Olivier.David@inserm.fr AB - In patients with pharmaco-resistant focal epilepsies investigated with intracranial electroencephalography (iEEG), direct electrical stimulations of a cortical region induce cortico-cortical evoked potentials (CCEP) in distant cerebral cortex, which properties can be used to infer large scale brain connectivity. In 2013, we proposed a new probabilistic functional tractography methodology to study human brain connectivity. We have now been revisiting this method in the F-TRACT project (f-tract.eu) by developing a large multicenter CCEP database of several thousand stimulation runs performed in several hundred patients, and associated processing tools to create a probabilistic atlas of human cortico-cortical connections. Here, we wish to present a snapshot of the methods and data of F-TRACT using a pool of 213 epilepsy patients, all studied by stereo-encephalography with intracerebral depth electrodes. The CCEPs were processed using an automated pipeline with the following consecutive steps: detection of each stimulation run from stimulation artifacts in raw intracranial EEG (iEEG) files, bad channels detection with a machine learning approach, model-based stimulation artifact correction, robust averaging over stimulation pulses. Effective connectivity between the stimulated and recording areas is then inferred from the properties of the first CCEP component, i.e. onset and peak latency, amplitude, duration and integral of the significant part. Finally, group statistics of CCEP features are implemented for each brain parcel explored by iEEG electrodes. The localization (coordinates, white/gray matter relative positioning) of electrode contacts were obtained from imaging data (anatomical MRI or CT scans before and after electrodes implantation). The iEEG contacts were repositioned in different brain parcellations from the segmentation of patients' anatomical MRI or from templates in the MNI coordinate system. The F-TRACT database using the first pool of 213 patients provided connectivity probability values for 95% of possible intrahemispheric and 56% of interhemispheric connections and CCEP features for 78% of intrahemisheric and 14% of interhemispheric connections. In this report, we show some examples of anatomo-functional connectivity matrices, and associated directional maps. We also indicate how CCEP features, especially latencies, are related to spatial distances, and allow estimating the velocity distribution of neuronal signals at a large scale. Finally, we describe the impact on the estimated connectivity of the stimulation charge and of the contact localization according to the white or gray matter. The most relevant maps for the scientific community are available for download on f-tract. eu (David et al., 2017) and will be regularly updated during the following months with the addition of more data in the F-TRACT database. This will provide an unprecedented knowledge on the dynamical properties of large fiber tracts in human. LA - English DB - MTMT ER - TY - JOUR AU - Waters, Allison C. AU - Veerakumar, Ashan AU - Choi, Ki Sueng AU - Howell, Bryan AU - Tiruvadi, Vineet AU - Bijanki, Kelly R. AU - Crowell, Andrea AU - Riva-Posse, Patricio AU - Mayberg, Helen S. TI - Test-retest reliability of a stimulation-locked evoked response to deep brain stimulation in subcallosal cingulate for treatment resistant depression JF - HUMAN BRAIN MAPPING J2 - HUM BRAIN MAPP VL - 39 PY - 2018 IS - 12 SP - 4844 EP - 4856 PG - 13 SN - 1065-9471 DO - 10.1002/hbm.24327 UR - https://m2.mtmt.hu/api/publication/30387613 ID - 30387613 N1 - Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, United States Cited By :5 Export Date: 18 August 2020 CODEN: HBMAE Correspondence Address: Waters, A.C.; Department of Psychiatry and Behavioral Sciences, Emory University School of MedicineUnited States; email: alliwaters@emory.edu AB - Deep brain stimulation (DBS) to the subcallosal cingulate cortex (SCC) is an emerging therapy for treatment resistant depression. Precision targeting of specific white matter fibers is now central to the model of SCC DBS treatment efficacy. A method to confirm SCC DBS target engagement is needed to reduce procedural variance across treatment providers and to optimize DBS parameters for individual patients. We examined the reliability of a novel cortical evoked response that is time-locked to a 2 Hz DBS pulse and shows the propagation of signal from the DBS target. The evoked response was detected in four individuals as a stereotyped series of components within 150 ms of a 6 V DBS pulse, each showing coherent topography on the head surface. Test-retest reliability across four repeated measures over 14 months met or exceeded standards for valid test construction in three of four patients. Several observations in this pilot sample demonstrate the prospective utility of this method to confirm surgical target engagement and instruct parameter selection. The topography of an orbital frontal component on the head surface showed specificity for patterns of forceps minor activation, which may provide a means to confirm DBS location with respect to key white matter structures. A divergent cortical response to unilateral stimulation of left (vs. right) hemisphere underscores the need for feedback acuity on the level of a single electrode, despite bilateral presentation of therapeutic stimulation. Results demonstrate viability of this method to explore patient-specific cortical responsivity to DBS for brain-circuit pathologies. LA - English DB - MTMT ER - TY - JOUR AU - Zhang, Nan AU - Zhang, Bingqing AU - Rajah, Gary B. AU - Geng, Xiaokun AU - Singh, Rasanjeet AU - Yang, Yanfeng AU - Yan, Xiupeng AU - Li, Zhe AU - Zhou, Wenjing AU - Ding, Yuchuan AU - Sun, Wei TI - The effectiveness of cortico-cortical evoked potential in detecting seizure onset zones JF - NEUROLOGICAL RESEARCH J2 - NEUROL RES VL - 40 PY - 2018 IS - 6 SP - 480 EP - 490 PG - 11 SN - 0161-6412 DO - 10.1080/01616412.2018.1454092 UR - https://m2.mtmt.hu/api/publication/30387620 ID - 30387620 N1 - Funding Agency and Grant Number: National Natural Science Foundation of China [81571267]; capital health research and development of special [2016-2-2013] Funding text: This work was supported by National Natural Science Foundation of China [grant number 81571267] and the capital health research and development of special (2016-2-2013). AB - Objective:The aim of the study was to evaluate the parameters for localizing the seizure onset zone in refractory epilepsy patients using cortico-cortical evoked potentials (CCEP). LA - English DB - MTMT ER - TY - JOUR AU - Blenkmann, Alejandro O AU - Phillips, Holly N AU - Princich, Juan P AU - Rowe, James B AU - Bekinschtein, Tristan A AU - Muravchik, Carlos H AU - Kochen, Silvia TI - iElectrodes: A Comprehensive Open-Source Toolbox for Depth and Subdural Grid Electrode Localization JF - FRONTIERS IN NEUROINFORMATICS J2 - FRONT NEUROINFORM VL - 11 PY - 2017 PG - 16 SN - 1662-5196 DO - 10.3389/fninf.2017.00014 UR - https://m2.mtmt.hu/api/publication/26556185 ID - 26556185 N1 - Funding Agency and Grant Number: Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Agencia Nacional de Promocion Cientifica y Tecnologica [PIDC 53/2012, PICT 0775/2012, PICT 1232/2014]; Universidad Nacional Arturo Jauretche Investiga; Comision de Investigaciones Cientificas (CIC); Medical Research Council [MC-A060-5PQ30]; Wellcome Trust [103838, WT093811MA]; James F. McDonnell Foundation 21st Century Science Initiative: Understanding Human Cognition; MRC [MC_U105597119, MC_UU_00005/12] Funding Source: UKRI; Medical Research Council [MC_UU_00005/12, MC_U105597119, 1233633] Funding Source: researchfish; Wellcome Trust [103838/Z/14/Z] Funding Source: researchfish Funding text: This work was supported by Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) to AB and SK, Agencia Nacional de Promocion Cientifica y Tecnologica (PIDC 53/2012 and PICT 0775/2012 to AB, JP, SK, and PICT 1232/2014 to CM), Universidad Nacional Arturo Jauretche Investiga 2014 to AB and SK, Comision de Investigaciones Cientificas (CIC) to CHM, Medical Research Council (MC-A060-5PQ30 to JR and a Doctoral Training award to HP), Wellcome Trust (103838 Senior Research Fellowship to JR, Biomedical Research Fellowship; WT093811MA to TB), the James F. McDonnell Foundation 21st Century Science Initiative: Understanding Human Cognition to JR. LA - English DB - MTMT ER - TY - JOUR AU - Duffau, Hugues TI - A two-level model of interindividual anatomo-functional variability of the brain and its implications for neurosurgery JF - CORTEX: A JOURNAL DEVOTED TO THE STUDY OF THE NERVOUS SYSTEM AND BEHAVIOR J2 - CORTEX VL - 86 PY - 2017 SP - 303 EP - 313 PG - 11 SN - 0010-9452 DO - 10.1016/j.cortex.2015.12.009 UR - https://m2.mtmt.hu/api/publication/26556206 ID - 26556206 LA - English DB - MTMT ER - TY - JOUR AU - Gollo, Leonardo L AU - Roberts, James A AU - Cocchi, Luca TI - Mapping how local perturbations influence systems-level brain dynamics JF - NEUROIMAGE J2 - NEUROIMAGE VL - 160 PY - 2017 SP - 97 EP - 112 PG - 16 SN - 1053-8119 DO - 10.1016/j.neuroimage.2017.01.057 UR - https://m2.mtmt.hu/api/publication/27072840 ID - 27072840 N1 - Funding Agency and Grant Number: Australian Research Council Centre of Excellence for Integrative Brain Function (ARC Centre Grant) [CE140100007]; National Health and Medical Research Council (NHMRC) [APP1110975, APP1099082] Funding text: We thank Penelope Kale for assistance in figure design. This work was supported by the Australian Research Council Centre of Excellence for Integrative Brain Function (ARC Centre Grant CE140100007) (JR) and the National Health and Medical Research Council (NHMRC): APP1110975 (LG), APP1099082 (LC). LA - English DB - MTMT ER - TY - JOUR AU - Groppe, David M AU - Bickel, Stephan AU - Dykstra, Andrew R AU - Wang, Xiuyuan AU - Megevand, Pierre AU - Mercier, Manuel R AU - Lado, Fred A AU - Mehta, Ashesh D AU - Honey, Christopher J TI - iELVis: An open source MATLAB toolbox for localizing and visualizing human intracranial electrode data JF - JOURNAL OF NEUROSCIENCE METHODS J2 - J NEUROSCI METH VL - 281 PY - 2017 SP - 40 EP - 48 PG - 9 SN - 0165-0270 DO - 10.1016/j.jneumeth.2017.01.022 UR - https://m2.mtmt.hu/api/publication/26556183 ID - 26556183 N1 - Funding Agency and Grant Number: Swiss National Science Foundation [PBGEP3_139829, P300P3_148388]; Page and Otto Marx Jr. Foundation; Natural Sciences and Engineering Research Council of Canada [RGPIN-2014-04465] Funding text: We thank the patients for consenting to provide the data that made this toolbox possible. Moreover, we thank Miklos Argyelan, Kathrin Nisch, Taufik Valiante, and Jaime Gomez for helping to debug and to develop this software. This work was supported by the Swiss National Science Foundation (grants PBGEP3_139829 and P300P3_148388 to PM), the Page and Otto Marx Jr. Foundation (to ADM), and by the Natural Sciences and Engineering Research Council of Canada (RGPIN-2014-04465 to CJH). LA - English DB - MTMT ER - TY - JOUR AU - Kadipasaoglu, Cihan Mehmet AU - Conner, Christopher Richard AU - Baboyan, Vatche George AU - Rollo, Matthew AU - Pieters, Thomas Allyn AU - Tandon, Nitin TI - Network dynamics of human face perception JF - PLOS ONE J2 - PLOS ONE VL - 12 PY - 2017 IS - 11 PG - 31 SN - 1932-6203 DO - 10.1371/journal.pone.0188834 UR - https://m2.mtmt.hu/api/publication/27277944 ID - 27277944 N1 - Funding Agency and Grant Number: National Center for Advancing Translational Sciences of the National Institutes of Health [5TL1TR000369-07]; National Institute for Deafness and Communication Disorders [U01NS098981, R01DC014589]; NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC014589] Funding Source: NIH RePORTER Funding text: Research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health (5TL1TR000369-07), and the National Institute for Deafness and Communication Disorders (Grants U01NS098981 and R01DC014589). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. LA - English DB - MTMT ER - TY - JOUR AU - Keller, Corey J AU - Davidesco, Ido AU - Megevand, Pierre AU - Lado, Fred A AU - Malach, Rafael AU - Mehta, Ashesh D TI - Tuning Face Perception with Electrical Stimulation of the Fusiform Gyrus JF - HUMAN BRAIN MAPPING J2 - HUM BRAIN MAPP VL - 38 PY - 2017 IS - 6 SP - 2830 EP - 2842 PG - 13 SN - 1065-9471 DO - 10.1002/hbm.23543 UR - https://m2.mtmt.hu/api/publication/26741212 ID - 26741212 N1 - Cited By :7 Export Date: 30 April 2020 CODEN: HBMAE Correspondence Address: Mehta, A.D.; Department of Neurosurgery, Hofstra Northwell School of Medicine, and Feinstein Institute for Medical ResearchUnited States; email: amehta@northwell.edu Cited By :9 Export Date: 18 August 2020 CODEN: HBMAE Correspondence Address: Mehta, A.D.; Department of Neurosurgery, Hofstra Northwell School of Medicine, and Feinstein Institute for Medical ResearchUnited States; email: amehta@northwell.edu Cited By :10 Export Date: 19 January 2021 CODEN: HBMAE Correspondence Address: Mehta, A.D.; Department of Neurosurgery, Hofstra Northwell School of Medicine, and Feinstein Institute for Medical ResearchUnited States; email: amehta@northwell.edu LA - English DB - MTMT ER - TY - JOUR AU - Krieg, Julien AU - Koessler, Laurent AU - Jonas, Jacques AU - Colnat-Coulbois, Sophie AU - Vignal, Jean-Pierre AU - Benar, Christian G AU - Maillard, Louis G TI - Discrimination of a medial functional module within the temporal lobe using an effective connectivity model: A CCEP study JF - NEUROIMAGE J2 - NEUROIMAGE VL - 161 PY - 2017 SP - 219 EP - 231 PG - 13 SN - 1053-8119 DO - 10.1016/j.neuroimage.2017.07.061 UR - https://m2.mtmt.hu/api/publication/27072839 ID - 27072839 N1 - Université de Lorraine, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, Vandœuvre-lès-Nancy, 54500, France CNRS, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, Vandœuvre-lès-Nancy, 54500, France Service de Neurologie, Centre Hospitalier Universitaire de Nancy, 29 Avenue Du Maréchal de Lattre de Tassigny, Nancy, 54000, France Service de Neurochirurgie, Centre Hospitalier Universitaire de Nancy, 29 Avenue Du Maréchal de Lattre de Tassigny, Nancy, 54000, France Faculté de Médecine de Nancy, Université de Lorraine, 9 Avenue de La Forêt de Haye, Vandœuvre-lès-Nancy, 54500, France Université Catholique de Louvain, 10 Place Du Cardinal Mercier, Louvain-La-Neuve, 1348, Belgium Aix Marseille Université, Institut de Neurosciences des Systèmes, Marseille, F-13005, France INSERM, UMR 1106, Marseille, 13005, France Cited By :4 Export Date: 30 April 2020 CODEN: NEIME Correspondence Address: Krieg, J.; Université de Lorraine, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, France; email: julien.krieg@univ-lorraine.fr Université de Lorraine, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, Vandœuvre-lès-Nancy, 54500, France CNRS, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, Vandœuvre-lès-Nancy, 54500, France Service de Neurologie, Centre Hospitalier Universitaire de Nancy, 29 Avenue Du Maréchal de Lattre de Tassigny, Nancy, 54000, France Service de Neurochirurgie, Centre Hospitalier Universitaire de Nancy, 29 Avenue Du Maréchal de Lattre de Tassigny, Nancy, 54000, France Faculté de Médecine de Nancy, Université de Lorraine, 9 Avenue de La Forêt de Haye, Vandœuvre-lès-Nancy, 54500, France Université Catholique de Louvain, 10 Place Du Cardinal Mercier, Louvain-La-Neuve, 1348, Belgium Aix Marseille Université, Institut de Neurosciences des Systèmes, Marseille, F-13005, France INSERM, UMR 1106, Marseille, 13005, France Cited By :5 Export Date: 18 August 2020 CODEN: NEIME Correspondence Address: Krieg, J.; Université de Lorraine, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, France; email: julien.krieg@univ-lorraine.fr Université de Lorraine, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, Vandœuvre-lès-Nancy, 54500, France CNRS, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, Vandœuvre-lès-Nancy, 54500, France Service de Neurologie, Centre Hospitalier Universitaire de Nancy, 29 Avenue Du Maréchal de Lattre de Tassigny, Nancy, 54000, France Service de Neurochirurgie, Centre Hospitalier Universitaire de Nancy, 29 Avenue Du Maréchal de Lattre de Tassigny, Nancy, 54000, France Faculté de Médecine de Nancy, Université de Lorraine, 9 Avenue de La Forêt de Haye, Vandœuvre-lès-Nancy, 54500, France Université Catholique de Louvain, 10 Place Du Cardinal Mercier, Louvain-La-Neuve, 1348, Belgium Aix Marseille Université, Institut de Neurosciences des Systèmes, Marseille, F-13005, France INSERM, UMR 1106, Marseille, 13005, France Cited By :6 Export Date: 19 January 2021 CODEN: NEIME Correspondence Address: Krieg, J.; Université de Lorraine, CRAN, UMR 7039, Campus Sciences, Boulevard des Aiguillettes, France; email: julien.krieg@univ-lorraine.fr LA - English DB - MTMT ER - TY - JOUR AU - Maliia, Mihai Dragos AU - Donos, Cristian AU - Barborica, Andrei AU - Mindruta, Ioana AU - Popa, Irina AU - Ene, Mirela AU - Beniczky, Sándor TI - High frequency spectral changes induced by single-pulse electric stimulation: Comparison between physiologic and pathologic networks JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 128 PY - 2017 IS - 6 SP - 1053 EP - 1060 PG - 8 SN - 1388-2457 DO - 10.1016/j.clinph.2016.12.016 UR - https://m2.mtmt.hu/api/publication/26741209 ID - 26741209 LA - English DB - MTMT ER - TY - JOUR AU - Matsumoto, Riki AU - Kunieda, Takeharu AU - Nair, Dileep TI - Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy JF - SEIZURE-EUROPEAN JOURNAL OF EPILEPSY J2 - SEIZURE-EUR J EPILEP VL - 44 PY - 2017 SP - 27 EP - 36 PG - 10 SN - 1059-1311 DO - 10.1016/j.seizure.2016.11.003 UR - https://m2.mtmt.hu/api/publication/27277950 ID - 27277950 N1 - Cited By :30 Export Date: 30 April 2020 CODEN: SEIZE Correspondence Address: Matsumoto, R.; Department of Neurology, Kyoto University Graduate School of MedicineJapan; email: matsumot@kuhp.kyoto-u.ac.jp Funding details: Kyoto University, R01NS089212 Funding details: Japan Epilepsy Research Foundation, JERF Funding details: National Institutes of Health, NIH Funding details: Ministry of Education, Culture, Sports, Science and Technology, MEXT Funding details: Ministry of Education, Culture, Sports, Science and Technology, MEXT Funding details: Cleveland Clinic Foundation, CCF, 15H01664, KAKENHI17790578, 23591273, 15H05874, 20591022, 26282218, 15K10361, 26560465 Funding details: National Institute of Neurological Disorders and Stroke, NINDS Funding text 1: The authors would like to thank Professors Hiroshi Shibasaki, Hans L?ders, and Akio Ikeda for their long-standing supports and advices for establishment of CCEP methodology. A series of CCEP studies have been partly supported by the Advanced International Clinical Fellowship Award from the Cleveland Clinic Foundation, KAKENHI17790578, 20591022, 23591273, 26282218, 26560465, 15H01664, 15H05874, 15K10361 from the Japan Ministry of Education, Culture, Sports, Science and Technology (MEXT), the Research Grants from the Japan Epilepsy Research Foundation, SPIRITS (Supporting Program for Interaction-based Initiative Team Studies) from Kyoto University, and R01NS089212 from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health. Cited By :36 Export Date: 18 August 2020 CODEN: SEIZE Correspondence Address: Matsumoto, R.; Department of Neurology, Kyoto University Graduate School of MedicineJapan; email: matsumot@kuhp.kyoto-u.ac.jp Cited By :44 Export Date: 19 January 2021 CODEN: SEIZE Correspondence Address: Matsumoto, R.; Department of Neurology, Kyoto University Graduate School of MedicineJapan; email: matsumot@kuhp.kyoto-u.ac.jp LA - English DB - MTMT ER - TY - JOUR AU - Mégevand, P AU - Groppe, DM AU - Bickel, S AU - Mercier, MR AU - Goldfinger, MS AU - Keller, CJ AU - Entz, László AU - Mehta, AD TI - The Hippocampus and Amygdala Are Integrators of Neocortical Influence: A CorticoCortical Evoked Potential Study JF - BRAIN CONNECTIVITY J2 - BRAIN CONNECT VL - 7 PY - 2017 IS - 10 SP - 648 EP - 660 PG - 13 SN - 2158-0014 DO - 10.1089/brain.2017.0527 UR - https://m2.mtmt.hu/api/publication/27052168 ID - 27052168 N1 - Funding Agency and Grant Number: Swiss National Science Foundation [P300P3_148388]; KTIA [NAP_13-1-20130001]; Page and Otto Marx Jr. Foundation; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007288] Funding Source: NIH RePORTER Funding text: We thank the patients for their participation and Willie Walker, Jr., the physicians, and other professionals of the Neurosurgery and Neurology departments of North Shore University Hospital for their assistance. We thank Michael D. Fox for helpful comments on the article. This work was supported by the Swiss National Science Foundation (grant P300P3_148388 to P.M.), KTIA (grant NAP_13-1-20130001 to L.E.), and the Page and Otto Marx Jr. Foundation. LA - English DB - MTMT ER - TY - JOUR AU - Shimada, Seijiro AU - Kunii, Naoto AU - Kawai, Kensuke AU - Matsuo, Takeshi AU - Ishishita, Yohei AU - Ibayashi, Kenji AU - Saito, Nobuhito TI - Impact of volume-conducted potential in interpretation of cortico-cortical evoked potential: Detailed analysis of high-resolution electrocorticography using two mathematical approaches JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 128 PY - 2017 IS - 4 SP - 549 EP - 557 PG - 9 SN - 1388-2457 DO - 10.1016/j.clinph.2017.01.012 UR - https://m2.mtmt.hu/api/publication/27277949 ID - 27277949 N1 - Department of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-kuTokyo 113-8655, Japan Department of Neurosurgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan Department of Neurosurgery, NTT Medical Center Tokyo, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo 141-8625, Japan Cited By :7 Export Date: 30 April 2020 CODEN: CNEUF Correspondence Address: Kunii, N.; Department of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Japan; email: nkunii-tky@umin.ac.jp Manufacturers: Unique Medical, Japan Funding details: Japan Society for the Promotion of Science, JSPS Funding text 1: This work was supported in part by Grant-in-Aid No. 26242040 for Scientific Research (A), No. 26462221 for Scientific Research (C), No. 16H06260 for Young Scientists (A), and No. 26861140 for Young Scientists (B) from the Japan Society for the Promotion of Science. Department of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-kuTokyo 113-8655, Japan Department of Neurosurgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan Department of Neurosurgery, NTT Medical Center Tokyo, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo 141-8625, Japan Cited By :7 Export Date: 18 August 2020 CODEN: CNEUF Correspondence Address: Kunii, N.; Department of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Japan; email: nkunii-tky@umin.ac.jp Department of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-kuTokyo 113-8655, Japan Department of Neurosurgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan Department of Neurosurgery, NTT Medical Center Tokyo, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo 141-8625, Japan Cited By :12 Export Date: 19 January 2021 CODEN: CNEUF Correspondence Address: Kunii, N.; Department of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Japan; email: nkunii-tky@umin.ac.jp LA - English DB - MTMT ER - TY - JOUR AU - Usami, Kiyohide AU - Matsumoto, Riki AU - Kobayashi, Katsuya AU - Hitomi, Takefumi AU - Matsuhashi, Masao AU - Shimotake, Akihiro AU - Kikuchi, Takayuki AU - Yoshida, Kazumichi AU - Kunieda, Takeharu AU - Mikuni, Nobuhiro AU - Miyamoto, Susumu AU - Takahashi, Ryosuke AU - Ikeda, Akio TI - Phasic REM Transiently Approaches Wakefulness in the Human Cortex-A Single-Pulse Electrical Stimulation Study JF - SLEEP J2 - SLEEP VL - 40 PY - 2017 IS - 8 PG - 7 SN - 0161-8105 DO - 10.1093/sleep/zsx077 UR - https://m2.mtmt.hu/api/publication/27277946 ID - 27277946 N1 - Funding Agency and Grant Number: MEXT KAKENHI [15H05874, 15K10361, 16K19510, 17H05907, 26282218, 26293209]; JSPS KAKENHI [17K16120]; Japan Epilepsy Research Foundation; Kyoto University Foundation; Grants-in-Aid for Scientific Research [15H05871] Funding Source: KAKEN Funding text: This research was partly funded by MEXT KAKENHI 15H05874, 15K10361, 16K19510, 17H05907, 26282218, 26293209, JSPS KAKENHI 17K16120, Research Grant from the Japan Epilepsy Research Foundation, and Grant from the Kyoto University Foundation. LA - English DB - MTMT ER - TY - JOUR AU - Vincent, Marion AU - Guiraud, David AU - Duffau, Hugues AU - Mandonnet, Emmanuel AU - Bonnetblanc, Francois TI - Electrophysiological brain mapping: Basics of recording evoked potentials induced by electrical stimulation and its physiological spreading in the human brain JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 128 PY - 2017 IS - 10 SP - 1886 EP - 1890 PG - 5 SN - 1388-2457 DO - 10.1016/j.clinph.2017.07.402 UR - https://m2.mtmt.hu/api/publication/27072812 ID - 27072812 LA - English DB - MTMT ER - TY - JOUR AU - Alagapan, Sankaraleengam AU - Schmidt, Stephen L AU - Lefebvre, Jeremie AU - Hadar, Eldad AU - Shin, Hae Won AU - Froehlich, Flavio TI - Modulation of Cortical Oscillations by Low-Frequency Direct Cortical Stimulation Is State-Dependent JF - PLOS BIOLOGY J2 - PLOS BIOL VL - 14 PY - 2016 IS - 3 PG - 21 SN - 1544-9173 DO - 10.1371/journal.pbio.1002424 UR - https://m2.mtmt.hu/api/publication/25830237 ID - 25830237 N1 - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Krembil Research Institute, University Health Network, Toronto, ON, Canada Department of Mathematics, University of Toronto, Toronto, ON, Canada Department of Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Neurobiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Cited By :57 Export Date: 18 August 2020 CODEN: PBLIB Correspondence Address: Frӧhlich, F.; Department of Psychiatry, University of North Carolina at Chapel HillUnited States; email: flavio_frohlich@med.unc.edu LA - English DB - MTMT ER - TY - JOUR AU - Boulogne, S AU - Ryvlin, P AU - Rheims, S TI - Single and paired-pulse electrical stimulation during invasive EEG recordings JF - REVUE NEUROLOGIQUE J2 - REV NEUROL-FRANCE VL - 172 PY - 2016 IS - 3 SP - 174 EP - 181 PG - 8 SN - 0035-3787 DO - 10.1016/j.neurol.2016.02.004 UR - https://m2.mtmt.hu/api/publication/26022699 ID - 26022699 N1 - Cited By :2 Export Date: 30 April 2020 CODEN: RENEA Correspondence Address: Rheims, S.; Lyon's Research Neuroscience Center, Inserm U1028/CNRS UMPR 5292, CH Le Vinatier, 95, boulevard Pinel, France; email: sylvain.rheims@univ-lyon1.fr Cited By :2 Export Date: 18 August 2020 CODEN: RENEA Correspondence Address: Rheims, S.; Lyon's Research Neuroscience Center, Inserm U1028/CNRS UMPR 5292, CH Le Vinatier, 95, boulevard Pinel, France; email: sylvain.rheims@univ-lyon1.fr Cited By :2 Export Date: 19 January 2021 CODEN: RENEA Correspondence Address: Rheims, S.; Lyon's Research Neuroscience Center, Inserm U1028/CNRS UMPR 5292, CH Le Vinatier, 95, boulevard Pinel, France; email: sylvain.rheims@univ-lyon1.fr LA - English DB - MTMT ER - TY - JOUR AU - Foster, B.L. AU - He, B.J. AU - Honey, C.J. AU - Jerbi, K. AU - Maier, A. AU - Saalmann, Y.B. TI - Spontaneous neural dynamics and multi-scale network organization JF - FRONTIERS IN SYSTEMS NEUROSCIENCE J2 - FRONT SYST NEUROSCI VL - 10 PY - 2016 IS - 7 PG - 20 SN - 1662-5137 DO - 10.3389/fnsys.2016.00007 UR - https://m2.mtmt.hu/api/publication/32119422 ID - 32119422 LA - English DB - MTMT ER - TY - JOUR AU - Guo, Zhiqiang AU - Huang, Xiyan AU - Wang, Meng AU - Jones, Jeffery A AU - Dai, Zhengjia AU - Li, Weifeng AU - Liu, Peng AU - Liu, Hanjun TI - Regional homogeneity of intrinsic brain activity correlates with auditory-motor processing of vocal pitch errors JF - NEUROIMAGE J2 - NEUROIMAGE VL - 142 PY - 2016 SP - 565 EP - 575 PG - 11 SN - 1053-8119 DO - 10.1016/j.neuroimage.2016.08.005 UR - https://m2.mtmt.hu/api/publication/26380417 ID - 26380417 N1 - Funding Agency and Grant Number: National Natural Science Foundation of China [31371135, 81301675, 81472154]; Guangdong Natural Science Funds [S2013050014470]; Guangdong Province Science and Technology Plan Project [2013B022000058]; Guangzhou Science and Technology Programme [201604020115]; Fundamental Research Funds for the Central Universities [13ykzd05, 15ykjc13b] Funding text: The authors thank Dr. Yufeng Zang at Hangzhou Normal University for his help with the data analysis. This study was funded by grants from National Natural Science Foundation of China (Nos. 31371135, 81301675 and 81472154), Guangdong Natural Science Funds for Distinguished Young Scholar (No. S2013050014470), Guangdong Province Science and Technology Plan Project (No. 2013B022000058), Guangzhou Science and Technology Programme (No. 201604020115), and the Fundamental Research Funds for the Central Universities (Nos. 13ykzd05 and 15ykjc13b). Zhiqiang Guo, Xiyan Huang, and Meng Wang contributed equally to this work. LA - English DB - MTMT ER - TY - JOUR AU - Hartwright, Charlotte E AU - Hardwick, Robert M AU - Apperly, Ian A AU - Hansen, Peter C TI - Resting state morphology predicts the effect of theta burst stimulation in false belief reasoning JF - HUMAN BRAIN MAPPING J2 - HUM BRAIN MAPP VL - 37 PY - 2016 IS - 10 SP - 3502 EP - 3514 PG - 13 SN - 1065-9471 DO - 10.1002/hbm.23255 UR - https://m2.mtmt.hu/api/publication/26208196 ID - 26208196 N1 - Funding Agency and Grant Number: Economic and Social Research Council [ES/G01258X/1] Funding text: Contract grant sponsor: Economic and Social Research Council; Contract grant number: ES/G01258X/1. LA - English DB - MTMT ER - TY - JOUR AU - Matthews, Paul M AU - Hampshire, Adam TI - Clinical Concepts Emerging from fMRI Functional Connectomics JF - NEURON J2 - NEURON VL - 91 PY - 2016 IS - 3 SP - 511 EP - 528 PG - 18 SN - 0896-6273 DO - 10.1016/j.neuron.2016.07.031 UR - https://m2.mtmt.hu/api/publication/26208197 ID - 26208197 N1 - Funding Agency and Grant Number: Imperial College Healthcare Trust Biomedical Research Centre; Edmond J. Safra Foundation; Medical Research Council; Engineering and Physics Science Research Council; GlaxoSmithKline; EC Marie Curie CIG; Medical Research Council [MR/M024903/1] Funding Source: researchfish; National Institute for Health Research [NF-SI-0514-10022] Funding Source: researchfish; MRC [MR/M024903/1] Funding Source: UKRI Funding text: The authors thank Drs. Charlotte Stagg, Rob Leech, and Saad Jbabdi and Prof. Richard Wise for reviewing sections of the draft manuscript. They gratefully acknowledge support from the Imperial College Healthcare Trust Biomedical Research Centre. P.M.M. is in receipt of generous personal and research support from the Edmond J. Safra Foundation and Lily Safra, the Medical Research Council, and the Engineering and Physics Science Research Council for aspects of this work. Imaging research conducted by P.M.M. has benefited from research funds or "in kind" donations of scanning time from GlaxoSmithKline. Some of the work conducted by P.M.M. that is reviewed here was performed while he was an employee of GlaxoSmithKline. Some of the research conducted by A.H. that is cited was supported by an EC Marie Curie CIG. LA - English DB - MTMT ER - TY - JOUR AU - Trebaul, Lena AU - Rudrauf, David AU - Job, Anne-Sophie AU - Maliia, Mihai Dragos AU - Popa, Irina AU - Barborica, Andrei AU - Minotti, Lorella AU - Mindruta, Ioana AU - Kahane, Philippe AU - David, Olivier TI - Stimulation artifact correction method for estimation of early cortico-cortical evoked potentials JF - JOURNAL OF NEUROSCIENCE METHODS J2 - J NEUROSCI METH VL - 264 PY - 2016 SP - 94 EP - 102 PG - 9 SN - 0165-0270 DO - 10.1016/j.jneumeth.2016.03.002 UR - https://m2.mtmt.hu/api/publication/26022698 ID - 26022698 N1 - Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, F-38000, France Inserm, U1216, Grenoble, F-38000, France Laboratoire de Neurophysiopathologie de l'Epilepsie, Centre Hospitalier Universitaire Grenoble-Alpes, Grenoble, France Neurology Department, University Emergency Hospital, Bucharest, Romania Physics Department, University of Bucharest, Bucharest, Romania FHC Inc, Bowdoin, ME, United States Neurology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Cited By :13 Export Date: 30 April 2020 CODEN: JNMED Correspondence Address: David, O.; Grenoble Institut des Neurosciences, Chemin Fortuné Ferrini, Bât EJ Safra, CHU Grenoble-AlpesFrance; email: Olivier.David@inserm.fr Funding details: Seventh Framework Programme, FP7, FP/2007-2013 Funding details: European Research Council, ERC Funding details: Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii, UEFISCDI, PN-II-ID-PCE-2011-3-0240 Funding details: DRCI 1325 Funding details: European Research Council, ERC, 616268 F-TRACT Funding text 1: The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme ( FP/2007-2013 )/ ERC Grant Agreement no. 616268 F-TRACT . This work was also funded by Romanian UEFISCDI Grant PN-II-ID-PCE-2011-3-0240 , and by a Grenoble-Alpes University Hospital grant ( DRCI 1325 , EPISTIM study). Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, F-38000, France Inserm, U1216, Grenoble, F-38000, France Laboratoire de Neurophysiopathologie de l'Epilepsie, Centre Hospitalier Universitaire Grenoble-Alpes, Grenoble, France Neurology Department, University Emergency Hospital, Bucharest, Romania Physics Department, University of Bucharest, Bucharest, Romania FHC Inc, Bowdoin, ME, United States Neurology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Cited By :15 Export Date: 18 August 2020 CODEN: JNMED Correspondence Address: David, O.; Grenoble Institut des Neurosciences, Chemin Fortuné Ferrini, Bât EJ Safra, CHU Grenoble-AlpesFrance; email: Olivier.David@inserm.fr Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, F-38000, France Inserm, U1216, Grenoble, F-38000, France Laboratoire de Neurophysiopathologie de l'Epilepsie, Centre Hospitalier Universitaire Grenoble-Alpes, Grenoble, France Neurology Department, University Emergency Hospital, Bucharest, Romania Physics Department, University of Bucharest, Bucharest, Romania FHC Inc, Bowdoin, ME, United States Neurology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Cited By :15 Export Date: 19 January 2021 CODEN: JNMED Correspondence Address: David, O.; Grenoble Institut des Neurosciences, Chemin Fortuné Ferrini, Bât EJ Safra, CHU Grenoble-AlpesFrance; email: Olivier.David@inserm.fr LA - English DB - MTMT ER - TY - JOUR AU - Vincent, Marion AU - Rossel, Olivier AU - Hayashibe, Mitsuhiro AU - Herbet, Guillaume AU - Duffau, Hugues AU - Guiraud, David AU - Bonnetblanc, Francois TI - The difference between electrical microstimulation and direct electrical stimulation - towards new opportunities for innovative functional brain mapping? JF - REVIEWS IN THE NEUROSCIENCES J2 - REV NEUROSCI VL - 27 PY - 2016 IS - 3 SP - 231 EP - 258 PG - 28 SN - 0334-1763 DO - 10.1515/revneuro-2015-0029 UR - https://m2.mtmt.hu/api/publication/26022713 ID - 26022713 LA - English DB - MTMT ER - TY - JOUR AU - Kunieda, Takeharu AU - Yamao, Yukihiro AU - Kikuchi, Takayuki AU - Matsumoto, Riki TI - New Approach for Exploring Cerebral Functional Connectivity: Review of Cortico-cortical Evoked Potential JF - NEUROLOGIA MEDICO-CHIRURGICA J2 - NEUROL MED-CHIR VL - 55 PY - 2015 IS - 5 SP - 374 EP - 382 PG - 9 SN - 0470-8105 DO - 10.2176/nmc.ra.2014-0388 UR - https://m2.mtmt.hu/api/publication/27277953 ID - 27277953 N1 - Departments of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan Departments of Epilepsy and Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan Cited By :17 Export Date: 30 April 2020 CODEN: NMCHB Correspondence Address: Kunieda, T.; Departments of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Shogoinkawahara-cho, Japan; email: kuny@kuhp.kyoto-u.ac.jp Departments of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan Departments of Epilepsy and Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan Cited By :21 Export Date: 18 August 2020 CODEN: NMCHB Correspondence Address: Kunieda, T.; Departments of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Shogoinkawahara-cho, Japan; email: kuny@kuhp.kyoto-u.ac.jp Departments of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan Departments of Epilepsy and Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan Cited By :23 Export Date: 19 January 2021 CODEN: NMCHB Correspondence Address: Kunieda, T.; Departments of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Shogoinkawahara-cho, Japan; email: kuny@kuhp.kyoto-u.ac.jp LA - English DB - MTMT ER - TY - JOUR AU - Martinet, Louis-Emmanuel AU - Ahmed, Omar J AU - Lepage, Kyle Q AU - Cash, Sydney S AU - Kramer, Mark A TI - Slow Spatial Recruitment of Neocortex during Secondarily Generalized Seizures and Its Relation to Surgical Outcome JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 35 PY - 2015 IS - 25 SP - 9477 EP - 9490 PG - 14 SN - 0270-6474 DO - 10.1523/JNEUROSCI.0049-15.2015 UR - https://m2.mtmt.hu/api/publication/25307393 ID - 25307393 N1 - Funding Agency and Grant Number: National Institute of Neurological Disorders and Stroke AwardUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS072023, SNS062092]; Epilepsy Foundation [222178]; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS072023, R01NS062092, R01NS062092, R01NS062092, R01NS062092, R01NS062092, R01NS072023, R01NS062092, R01NS062092, R01NS062092, R01NS072023, R01NS072023, R01NS072023] Funding Source: NIH RePORTER Funding text: This research is supported by National Institute of Neurological Disorders and Stroke Award R01NS072023 (to M.A.K. and S.S.C.) and Grant SNS062092 (to S.S.C.) and by the Epilepsy Foundation Grant 222178. We thank the patients who participated in this study and the nursing and physician staff. We also thank Jason Naftulin for technical assistance. LA - English DB - MTMT ER - TY - JOUR AU - Pakhomov, SVS AU - Jones, DT AU - Knopman, DS TI - Language networks associated with computerized semantic indices JF - NEUROIMAGE J2 - NEUROIMAGE VL - 104 PY - 2015 SP - 125 EP - 137 PG - 13 SN - 1053-8119 DO - 10.1016/j.neuroimage.2014.10.008 UR - https://m2.mtmt.hu/api/publication/24464267 ID - 24464267 N1 - Funding Agency and Grant Number: NIH [R01 LM009623, P50 AG016574, U01 AG006786, R01 AG041851, R01 AG011378]; Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program of the Mayo Foundation; NATIONAL INSTITUTE ON AGING [R01AG041851, R01AG011378, U01AG006786, P50AG016574] Funding Source: NIH RePORTER; NATIONAL LIBRARY OF MEDICINE [R01LM009623] Funding Source: NIH RePORTER Funding text: This work was supported by NIH grants R01 LM009623 (PI - Pakhomov), P50 AG016574 (PI - Ron Petersen), U01 AG006786 (PI - Ron Petersen), R01 AG041851 (PIs - David Knopman and Cliff Jack), R01 AG011378 (PI - Cliff Jack), and the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program of the Mayo Foundation. We are also deeply grateful to the participants in this study, their families, and caregivers. LA - English DB - MTMT ER - TY - JOUR AU - Pigorini, Andrea AU - Sarasso, Simone AU - Proserpio, Paola AU - Szymanski, Caroline AU - Arnulfo, Gabriele AU - Casarotto, Silvia AU - Fecchio, Matteo AU - Rosanova, Mario AU - Mariotti, Maurizio AU - Lo, Russo Giorgio AU - Palva, J Matias AU - Nobili, Lino AU - Massimini, Marcello TI - Bistability breaks-off deterministic responses to intracortical stimulation during non-REM sleep JF - NEUROIMAGE J2 - NEUROIMAGE VL - 112 PY - 2015 SP - 105 EP - 113 PG - 9 SN - 1053-8119 DO - 10.1016/j.neuroimage.2015.02.056 UR - https://m2.mtmt.hu/api/publication/24791386 ID - 24791386 N1 - Department of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Via G.B. Grassi 74, Milan, 20157, Italy Centre of Epilepsy Surgery C. Munari, Department of Neuroscience, Niguarda Hospital, Piazza Ospedale Maggiore 3, Milan, 20162, Italy Max Planck Institute for Human Development, Lentzeallee 94, Berlin, 14195, Germany Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FIN-00014, Finland Don C Gnocchi Foundation IRCCS, Via Alfonso Capecelatro 66, Milan, 20148, Italy Cited By :68 Export Date: 28 May 2020 CODEN: NEIME Correspondence Address: Massimini, M.; Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Via G.B. Grassi 74, Italy Funding details: European Commission, EC, 600806, FP7-ICT-2011-9 Funding details: James S. McDonnell Foundation, JSMF, 220020369, 2010SH7H3F_004 Funding text 1: We thank Adenauer Casali, Giulio Tononi, Chiara Cirelli, Corey J. Keller, Giandomenico Iannetti and Adam Barrett for insightful discussion and comments on the manuscript. This study was funded by EU grant FP7-ICT-2011-9 , n. 600806 “Corticonic”, James S. McDonnell Foundation Scholar Award 2013 #220020369 , and PRIN 2010 to M.M #2010SH7H3F_004 . Department of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Via G.B. Grassi 74, Milan, 20157, Italy Centre of Epilepsy Surgery C. Munari, Department of Neuroscience, Niguarda Hospital, Piazza Ospedale Maggiore 3, Milan, 20162, Italy Max Planck Institute for Human Development, Lentzeallee 94, Berlin, 14195, Germany Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FIN-00014, Finland Don C Gnocchi Foundation IRCCS, Via Alfonso Capecelatro 66, Milan, 20148, Italy Cited By :70 Export Date: 8 September 2020 CODEN: NEIME Correspondence Address: Massimini, M.; Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Via G.B. Grassi 74, Italy Department of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Via G.B. Grassi 74, Milan, 20157, Italy Centre of Epilepsy Surgery C. Munari, Department of Neuroscience, Niguarda Hospital, Piazza Ospedale Maggiore 3, Milan, 20162, Italy Max Planck Institute for Human Development, Lentzeallee 94, Berlin, 14195, Germany Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FIN-00014, Finland Don C Gnocchi Foundation IRCCS, Via Alfonso Capecelatro 66, Milan, 20148, Italy Cited By :75 Export Date: 1 December 2020 CODEN: NEIME Correspondence Address: Massimini, M.; Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Via G.B. Grassi 74, Italy; email: marcello.massimini@unimi.it Funding details: European Commission, EC, 600806, FP7-ICT-2011-9 Funding details: James S. McDonnell Foundation, JSMF, 220020369, 2010SH7H3F_004 Funding text 1: We thank Adenauer Casali, Giulio Tononi, Chiara Cirelli, Corey J. Keller, Giandomenico Iannetti and Adam Barrett for insightful discussion and comments on the manuscript. This study was funded by EU grant FP7-ICT-2011-9 , n. 600806 “Corticonic”, James S. McDonnell Foundation Scholar Award 2013 #220020369 , and PRIN 2010 to M.M #2010SH7H3F_004 . Department of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Via G.B. Grassi 74, Milan, 20157, Italy Centre of Epilepsy Surgery C. Munari, Department of Neuroscience, Niguarda Hospital, Piazza Ospedale Maggiore 3, Milan, 20162, Italy Max Planck Institute for Human Development, Lentzeallee 94, Berlin, 14195, Germany Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FIN-00014, Finland Don C Gnocchi Foundation IRCCS, Via Alfonso Capecelatro 66, Milan, 20148, Italy Cited By :77 Export Date: 19 January 2021 CODEN: NEIME Correspondence Address: Massimini, M.; Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Via G.B. Grassi 74, Italy; email: marcello.massimini@unimi.it Department of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Via G.B. Grassi 74, Milan, 20157, Italy Centre of Epilepsy Surgery C. Munari, Department of Neuroscience, Niguarda Hospital, Piazza Ospedale Maggiore 3, Milan, 20162, Italy Max Planck Institute for Human Development, Lentzeallee 94, Berlin, 14195, Germany Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FIN-00014, Finland Don C Gnocchi Foundation IRCCS, Via Alfonso Capecelatro 66, Milan, 20148, Italy Cited By :77 Export Date: 2 February 2021 CODEN: NEIME Correspondence Address: Massimini, M.; Department of Biomedical and Clinical Sciences, Via G.B. Grassi 74, Italy; email: marcello.massimini@unimi.it Department of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Via G.B. Grassi 74, Milan, 20157, Italy Centre of Epilepsy Surgery C. Munari, Department of Neuroscience, Niguarda Hospital, Piazza Ospedale Maggiore 3, Milan, 20162, Italy Max Planck Institute for Human Development, Lentzeallee 94, Berlin, 14195, Germany Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FIN-00014, Finland Don C Gnocchi Foundation IRCCS, Via Alfonso Capecelatro 66, Milan, 20148, Italy Cited By :81 Export Date: 8 April 2021 CODEN: NEIME Correspondence Address: Massimini, M.; Department of Biomedical and Clinical Sciences, Via G.B. Grassi 74, Italy; email: marcello.massimini@unimi.it Funding details: James S. McDonnell Foundation, JSMF, 2010SH7H3F_004, 220020369 Funding details: Seventh Framework Programme, FP7, 600806 Funding details: European Commission, EC, FP7-ICT-2011-9 Funding text 1: We thank Adenauer Casali, Giulio Tononi, Chiara Cirelli, Corey J. Keller, Giandomenico Iannetti and Adam Barrett for insightful discussion and comments on the manuscript. This study was funded by EU grant FP7-ICT-2011-9 , n. 600806 “Corticonic”, James S. McDonnell Foundation Scholar Award 2013 #220020369 , and PRIN 2010 to M.M #2010SH7H3F_004 . Department of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Via G.B. Grassi 74, Milan, 20157, Italy Centre of Epilepsy Surgery C. Munari, Department of Neuroscience, Niguarda Hospital, Piazza Ospedale Maggiore 3, Milan, 20162, Italy Max Planck Institute for Human Development, Lentzeallee 94, Berlin, 14195, Germany Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FIN-00014, Finland Don C Gnocchi Foundation IRCCS, Via Alfonso Capecelatro 66, Milan, 20148, Italy Cited By :81 Export Date: 26 April 2021 CODEN: NEIME Correspondence Address: Massimini, M.; Department of Biomedical and Clinical Sciences, Via G.B. Grassi 74, Italy; email: marcello.massimini@unimi.it Funding details: James S. McDonnell Foundation, JSMF, 2010SH7H3F_004, 220020369 Funding details: Seventh Framework Programme, FP7, 600806 Funding details: European Commission, EC, FP7-ICT-2011-9 Funding text 1: We thank Adenauer Casali, Giulio Tononi, Chiara Cirelli, Corey J. Keller, Giandomenico Iannetti and Adam Barrett for insightful discussion and comments on the manuscript. This study was funded by EU grant FP7-ICT-2011-9 , n. 600806 “Corticonic”, James S. McDonnell Foundation Scholar Award 2013 #220020369 , and PRIN 2010 to M.M #2010SH7H3F_004 . LA - English DB - MTMT ER - TY - JOUR AU - Somandepalli, Krishna AU - Kelly, Clare AU - Reiss, Philip T. AU - Zuo, Xi-Nian AU - Craddock, R. C. AU - Yan, Chao-Gan AU - Petkova, Eva AU - Castellanos, F. X. AU - Milham, Michael P. AU - Di, Martino Adriana TI - Short-term test-retest reliability of resting state fMRI metrics in children with and without attention-deficit/hyperactivity disorder JF - DEVELOPMENTAL COGNITIVE NEUROSCIENCE J2 - DEV COGN NEUROS-NETH VL - 15 PY - 2015 SP - 83 EP - 93 PG - 11 SN - 1878-9293 DO - 10.1016/j.dcn.2015.08.003 UR - https://m2.mtmt.hu/api/publication/33255269 ID - 33255269 N1 - Funding Agency and Grant Number: National Institute of Mental Health [K23MH087770, R01MH081218, 5U01MH099059]; National Institute of Child Health and Human Development [R01HD065282]; Stavros Niarchos Foundation; Leon Levy Foundation; Major Joint Fund for International Cooperation and Exchange of the National Natural Science Foundation [81220108014]; Natural Science Foundation of China [81171409]; Chinese Academy of Sciences Key Research Program [KSZD-EW-TZ-002]; EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD065282] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH081218, U01MH099059, K23MH087770] Funding Source: NIH RePORTER Funding text: This work was supported by grants from National Institute of Mental Health (K23MH087770 to ADM; R01MH081218 to FXC; 5U01MH099059 to MPM); from the National Institute of Child Health and Human Development (R01HD065282 to FXC), the Stavros Niarchos Foundation (FXC and MPM); the Leon Levy Foundation (MPM, ADM, and CK); as well as the Major Joint Fund for International Cooperation and Exchange of the National Natural Science Foundation (81220108014), the Natural Science Foundation of China (81171409), the Chinese Academy of Sciences Key Research Program (CAS: KSZD-EW-TZ-002) and the support of the "CAS Hundred Talents" program to XNZ. No funding sources contributed to preparing this manuscript. AB - To date, only one study has examined test-retest reliability of resting state fMRI (R-fMRI) in children, none in clinical developing groups. Here, we assessed short-term test-retest reliability in a sample of 46 children (11-17.9 years) with attention-deficit/hyperactivity disorder (ADHD) and 57 typically developing children (TDC). Our primary test-retest reliability measure was the intraclass correlation coefficient (ICC), quantified for a range of R-fMRI metrics. We aimed to (1) survey reliability within and across diagnostic groups, and (2) compare voxel-wise ICC between groups. We found moderate-to-high ICC across all children and within groups, with higher-order functional networks showing greater ICC. Nearly all R-fMRI metrics exhibited significantly higher ICC in TDC than in children with ADHD for one or more regions. In particular, posterior cingulate and ventral precuneus exhibited group differences in ICC across multiple measures. In the context of overall moderate-to-high test-retest reliability in children, regional differences in ICC related to diagnostic groups likely reflect the underlying pathophysiology for ADHD. Our currently limited understanding of the factors contributing to inter- and intra-subject variability in ADHD underscores the need for large initiatives aimed at examining their impact on test-retest reliability in both clinical and developing populations. (C) 2015 Published by Elsevier Ltd. LA - English DB - MTMT ER - TY - JOUR AU - Somandepalli, Krishna AU - Kelly, Clare AU - Reiss, Philip T AU - Zuo, Xi-Nian AU - Craddock, R C AU - Yan, Chao-Gan AU - Petkova, Eva AU - Castellanos, F X AU - Milham, Michael P AU - Di Martino, Adriana TI - Short-term test-retest reliability of resting state fMRI metrics in children with and without attention-deficit/hyperactivity disorder JF - DEVELOPMENTAL COGNITIVE NEUROSCIENCE J2 - DEV COGN NEUROS-NETH VL - 15 PY - 2015 SP - 83 EP - 93 PG - 11 SN - 1878-9293 DO - 10.1016/j.den.2015.08.003 UR - https://m2.mtmt.hu/api/publication/25307395 ID - 25307395 LA - English DB - MTMT ER - TY - JOUR AU - Usami, Kiyohide AU - Matsumoto, Riki AU - Kobayashi, Katsuya AU - Hitomi, Takefumi AU - Shimotake, Akihiro AU - Kikuchi, Takayuki AU - Matsuhashi, Masao AU - Kunieda, Takeharu AU - Mikuni, Nobuhiro AU - Miyamoto, Susumu AU - Fukuyama, Hidenao AU - Takahashi, Ryosuke AU - Ikeda, Akio TI - Sleep modulates cortical connectivity and excitability in humans: Direct evidence from neural activity induced by single-pulse electrical stimulation JF - HUMAN BRAIN MAPPING J2 - HUM BRAIN MAPP VL - 36 PY - 2015 IS - 11 SP - 4714 EP - 4729 PG - 16 SN - 1065-9471 DO - 10.1002/hbm.22948 UR - https://m2.mtmt.hu/api/publication/25307394 ID - 25307394 N1 - Funding Agency and Grant Number: Kyoto University Foundation; MEXT/JSPS KAKENHI [26560465, 15K10361, 26282218, 15H05874, 15H01664]; Japan Epilepsy Research Foundation; Grants-in-Aid for Scientific Research [26560465, 15H05871] Funding Source: KAKEN Funding text: Contract grant sponsor: Kyoto University Foundation; Contract grant sponsor: MEXT/JSPS KAKENHI; Contract grant numbers: 26560465, 15K10361, 26282218, 15H05874, 15H01664; Contract grant sponsor: Japan Epilepsy Research Foundation LA - English DB - MTMT ER - TY - JOUR AU - Yaffe, Robert B AU - Borger, Philip AU - Megevand, Pierre AU - Groppe, David M AU - Kramer, Mark A AU - Chu, Catherine J AU - Santaniello, Sabato AU - Meisel, Christian AU - Mehta, Ashesh D AU - Sarma, Sridevi V TI - Physiology of functional and effective networks in epilepsy JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 126 PY - 2015 IS - 2 SP - 227 EP - 236 PG - 10 SN - 1388-2457 DO - 10.1016/j.clinph.2014.09.009 UR - https://m2.mtmt.hu/api/publication/27277954 ID - 27277954 N1 - Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, United States Department of Neurosurgery, Hofstra North Shore-LIJ School of Medicine and Feinstein Institute for Medical Research, Manhasset, NY 11030, United States Department of Mathematics and Statistics, Boston University, Boston, MA 02215, United States Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, United States Harvard Medical School, Boston, MA 02115, United States National Institute of Mental Health, Bethesda, MD 20892, United States Cited By :49 Export Date: 18 August 2020 CODEN: CNEUF Correspondence Address: Yaffe, R.B.; Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Hackerman Hall, 3400 North Charles Street, United States Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, United States Department of Neurosurgery, Hofstra North Shore-LIJ School of Medicine and Feinstein Institute for Medical Research, Manhasset, NY 11030, United States Department of Mathematics and Statistics, Boston University, Boston, MA 02215, United States Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, United States Harvard Medical School, Boston, MA 02115, United States National Institute of Mental Health, Bethesda, MD 20892, United States Cited By :55 Export Date: 19 January 2021 CODEN: CNEUF Correspondence Address: Yaffe, R.B.; Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Hackerman Hall, 3400 North Charles Street, United States; email: yaffer@jhu.edu LA - English DB - MTMT ER - TY - JOUR AU - Blank, I AU - Kanwisher, N AU - Fedorenko, E TI - A functional dissociation between language and multiple-demand systems revealed in patterns of BOLD signal fluctuations JF - JOURNAL OF NEUROPHYSIOLOGY J2 - J NEUROPHYSIOL VL - 112 PY - 2014 IS - 5 SP - 1105 EP - 1118 PG - 14 SN - 0022-3077 DO - 10.1152/jn.00884.2013 UR - https://m2.mtmt.hu/api/publication/24196931 ID - 24196931 N1 - Funding Agency and Grant Number: Ellison Medical Foundation; Simons Center; Eunice Kennedy Shriver National Institute of Child Health and Human Development Award [K99 HD-057522]; [EY13455]; EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [K99HD057522] Funding Source: NIH RePORTER; NATIONAL EYE INSTITUTE [R01EY013455] Funding Source: NIH RePORTER Funding text: Support for this research was provided by the following funding sources: grant EY13455 to N. Kanwisher, a grant from the Ellison Medical Foundation to N. Kanwisher, a seed grant from the Simons Center for the Social Brain to N. Kanwisher, and Eunice Kennedy Shriver National Institute of Child Health and Human Development Award K99 HD-057522 to E. Fedorenko. LA - English DB - MTMT ER - TY - JOUR AU - Entz, László AU - Tóth, Emília AU - Keller, CJ AU - Bickel, S AU - Groppe, DM AU - Fabó, Dániel AU - Kozák, Lajos Rudolf AU - Erőss, Loránd AU - Ulbert, István AU - Mehta, AD TI - Evoked effective connectivity of the human neocortex JF - HUMAN BRAIN MAPPING J2 - HUM BRAIN MAPP VL - 35 PY - 2014 IS - 12 SP - 5736 EP - 5753 PG - 18 SN - 1065-9471 DO - 10.1002/hbm.22581 UR - https://m2.mtmt.hu/api/publication/2717967 ID - 2717967 N1 - Department of Neurosurgery, Hofstra North Shore LIJ School of Medicine, Feinstein Institute of Medical Research, Manhasset, NY, United States Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, 1132, Hungary Department of Functional Neurosurgery and Department of Epilepsy, National Institute of Clinical Neuroscience, Budapest, 1145, Hungary Péter Pázmány Catholic University, Faculty of Information Technology and Bionics, Budapest, 1083, Hungary Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, United States Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, United States MR Research Center, Semmelweis University Budapest1083, Hungary Cited By :47 Export Date: 8 April 2021 CODEN: HBMAE Correspondence Address: Mehta, A.D.Mail: 611 Northern Boulevard, Suite 150, United States Funding details: National Institutes of Health, NIH Funding details: National Institute of General Medical Sciences, NIGMS, T32GM007288 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, F31NS080357 Department of Neurosurgery, Hofstra North Shore LIJ School of Medicine, Feinstein Institute of Medical Research, Manhasset, NY, United States Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, 1132, Hungary Department of Functional Neurosurgery and Department of Epilepsy, National Institute of Clinical Neuroscience, Budapest, 1145, Hungary Péter Pázmány Catholic University, Faculty of Information Technology and Bionics, Budapest, 1083, Hungary Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, United States Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, United States MR Research Center, Semmelweis University Budapest1083, Hungary Cited By :47 Export Date: 26 April 2021 CODEN: HBMAE Correspondence Address: Mehta, A.D.Mail: 611 Northern Boulevard, Suite 150, United States Funding details: National Institutes of Health, NIH Funding details: National Institute of General Medical Sciences, NIGMS, T32GM007288 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, F31NS080357 AB - The role of cortical connectivity in brain function and pathology is increasingly being recognized. While in vivo magnetic resonance imaging studies have provided important insights into anatomical and functional connectivity, these methodologies are limited in their ability to detect electrophysiological activity and the causal relationships that underlie effective connectivity. Here, we describe results of cortico-cortical evoked potential (CCEP) mapping using single pulse electrical stimulation in 25 patients undergoing seizure monitoring with subdural electrode arrays. Mapping was performed by stimulating adjacent electrode pairs and recording CCEPs from the remainder of the electrode array. CCEPs reliably revealed functional networks and showed an inverse relationship to distance between sites. Coregistration to Brodmann areas (BA) permitted group analysis. Connections were frequently directional with 43% of early responses and 50% of late responses of connections reflecting relative dominance of incoming or outgoing connections. The most consistent connections were seen as outgoing from motor cortex, BA6-BA9, somatosensory (SS) cortex, anterior cingulate cortex, and Broca's area. Network topology revealed motor, SS, and premotor cortices along with BA9 and BA10 and language areas to serve as hubs for cortical connections. BA20 and BA39 demonstrated the most consistent dominance of outdegree connections, while BA5, BA7, auditory cortex, and anterior cingulum demonstrated relatively greater indegree. This multicenter, large-scale, directional study of local and long-range cortical connectivity using direct recordings from awake, humans will aid the interpretation of noninvasive functional connectome studies. Hum Brain Mapp, 2014. (c) 2014 Wiley Periodicals, Inc. LA - English DB - MTMT ER - TY - JOUR AU - Fox, MD AU - Buckner, RL AU - Liu, HS AU - Chakravarty, MM AU - Lozano, AM AU - Pascual-Leone, A TI - Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 111 PY - 2014 IS - 41 SP - E4367 EP - E4375 PG - 9 SN - 0027-8424 DO - 10.1073/pnas.1405003111 UR - https://m2.mtmt.hu/api/publication/24464268 ID - 24464268 N1 - Megjegyzés-24270339 N1 Funding Details: K23NS083741, NIH, National Institutes of Health N1 Funding Details: R01HD069776, NIH, National Institutes of Health N1 Funding Details: R01NS073601, NIH, National Institutes of Health N1 Funding Details: R21HD07616, NIH, National Institutes of Health N1 Funding Details: R21MH099196, NIH, National Institutes of Health N1 Funding Details: R21NS082870, NIH, National Institutes of Health N1 Funding Details: R21NS085491, NIH, National Institutes of Health Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA 02129, United States Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, United States Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, United States Cerebral Imaging Centre, Douglas Mental Health Institute, Verdun, QC H4H 1R3, Canada Departments of Psychiatry and Biomedical Engineering, McGill University, Montreal, QC H3A 2B4, Canada Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, Toronto, ON M5T 2S8, Canada Krembil Neuroscience Center, University of Toronto, Toronto, ON M5T 2S8, Canada Cited By :188 Export Date: 30 September 2019 CODEN: PNASA Correspondence Address: Fox, M.D.; Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical SchoolUnited States LA - English DB - MTMT ER -