TY - JOUR AU - Jócsák, Gergely AU - Ioja, Enikő AU - Kiss, Dávid Sándor AU - Tóth, István AU - Bárány, Zoltán Balázs AU - Bartha, Tibor AU - Frenyó V., László AU - Zsarnovszky, Attila TI - Endocrine Disruptors Induced Distinct Expression of Thyroid and Estrogen Receptors in Rat versus Mouse Primary Cerebellar Cell Cultures JF - BRAIN SCIENCES J2 - BRAIN SCI VL - 9 PY - 2019 IS - 12 PG - 19 SN - 2076-3425 DO - 10.3390/brainsci9120359 UR - https://m2.mtmt.hu/api/publication/31194217 ID - 31194217 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Dávid Sándor AU - Ioja, E AU - Tóth, István AU - Bárány, Zoltán Balázs AU - Jócsák, Gergely AU - Bartha, Tibor AU - Horváth, Tamás AU - Zsarnovszky, Attila TI - Comparative Analysis of Zearalenone Effects on Thyroid Receptor Alpha (TR alpha) and Beta (TR beta) Expression in Rat Primary Cerebellar Cell Cultures JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 19 PY - 2018 IS - 5 PG - 17 SN - 1661-6596 DO - 10.3390/ijms19051440 UR - https://m2.mtmt.hu/api/publication/3393033 ID - 3393033 LA - English DB - MTMT ER - TY - JOUR AU - Zsarnovszky, Attila AU - Kiss, Dávid Sándor AU - Jócsák, Gergely AU - Németh, Gábor László AU - Tóth, István AU - Horváth, Tamás TI - Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum JF - FRONTIERS IN NEUROENDOCRINOLOGY J2 - FRONT NEUROENDOCRIN VL - 48 PY - 2018 IS - SI SP - 23 EP - 36 PG - 14 SN - 0091-3022 DO - 10.1016/j.yfrne.2017.10.001 UR - https://m2.mtmt.hu/api/publication/3278620 ID - 3278620 AB - Although the effects of phytoestrogens on brain function is widely unknown, they are often regarded as "natural" and thus as harmless. However, the effects of phytoestrogens or environmental pollutants on brain function is underestimated. Estrogen (17beta-estradiol, E2) and thyroid hormones (THs) play pivoltal roles in brain development. In the mature brain, these hormones regulate metabolism on cellular and organismal levels. Thus, E2 and THs do not only regulate the energy metabolism of the entire organism, but simultaneously also regulate important homeostatic parameters of neurons and glia in the CNS. It is, therefore, obvious that the mechanisms through which these hormones exert their effects are pleiotropic and include both intra- and intercellular actions. These hormonal mechanisms are versatile, and the experimental investigation of simultaneous hormone-induced mechanisms is technically challanging. In addition, the normal physiological settings of metabolic parameters depend on a plethora of interactions of the steroid hormones. In this review, we discuss conceptual and experimental aspects of the gonadal and thyroid hormones as they relate to in vitro models of the cerebellum. LA - English DB - MTMT ER - TY - JOUR AU - Gothie, Jean-David AU - Demeneix, Barbara AU - Remaud, Sylvie TI - Comparative approaches to understanding thyroid hormone regulation of neurogenesis JF - MOLECULAR AND CELLULAR ENDOCRINOLOGY J2 - MOL CELL ENDOCRINOL VL - 459 PY - 2017 IS - C SP - 104 EP - 115 PG - 12 SN - 0303-7207 DO - 10.1016/j.mce.2017.05.020 UR - https://m2.mtmt.hu/api/publication/27348520 ID - 27348520 N1 - Cited By :6 Export Date: 8 August 2019 CODEN: MCEND Correspondence Address: Demeneix, B.; CNRS, UMR 7221, Muséum National d'Histoire Naturelle, France; email: bdem@mnhn.fr Chemicals/CAS: Endocrine Disruptors; Thyroid Hormones Funding details: Association Française contre les Myopathies Funding details: Agence Nationale de la Recherche Funding details: 666869 Funding details: Olga Mayenfisch Stiftung Funding details: Centre National de la Recherche Scientifique Funding text 1: This work was supported by the EU FP7 contract Thyrage (grant number 666869), the AFM; ANR grants Thrast and OLGA; CNRS. Cited By :6 Export Date: 22 August 2019 CODEN: MCEND Correspondence Address: Demeneix, B.; CNRS, UMR 7221, Muséum National d'Histoire Naturelle, France; email: bdem@mnhn.fr Chemicals/CAS: Endocrine Disruptors; Thyroid Hormones Funding details: Association Française contre les Myopathies Funding details: Agence Nationale de la Recherche Funding details: 666869 Funding details: Olga Mayenfisch Stiftung Funding details: Centre National de la Recherche Scientifique Funding text 1: This work was supported by the EU FP7 contract Thyrage (grant number 666869), the AFM; ANR grants Thrast and OLGA; CNRS. Cited By :11 Export Date: 27 March 2020 CODEN: MCEND Correspondence Address: Demeneix, B.; CNRS, UMR 7221, Muséum National d'Histoire Naturelle, France; email: bdem@mnhn.fr Chemicals/CAS: Endocrine Disruptors; Thyroid Hormones Funding details: Association Française contre les Myopathies, AFM Funding details: Agence Nationale de la Recherche, ANR Funding details: 666869 Funding details: Olga Mayenfisch Stiftung Funding details: Centre National de la Recherche Scientifique, CNRS Funding text 1: This work was supported by the EU FP7 contract Thyrage (grant number 666869 ), the AFM ; ANR grants Thrast and OLGA ; CNRS . Cited By :15 Export Date: 4 February 2021 CODEN: MCEND Correspondence Address: Demeneix, B.; CNRS, Muséum National d'Histoire Naturelle, France; email: bdem@mnhn.fr Chemicals/CAS: Endocrine Disruptors; Thyroid Hormones Funding details: Association Française contre les Myopathies, AFM Funding details: Agence Nationale de la Recherche, ANR Funding details: 666869 Funding details: Centre National de la Recherche Scientifique, CNRS Funding text 1: This work was supported by the EU FP7 contract Thyrage (grant number 666869 ), the AFM ; ANR grants Thrast and OLGA ; CNRS . Cited By :17 Export Date: 29 March 2021 CODEN: MCEND Correspondence Address: Demeneix, B.; CNRS, Muséum National d'Histoire Naturelle, France; email: bdem@mnhn.fr Chemicals/CAS: Endocrine Disruptors; Thyroid Hormones Funding details: Association Française contre les Myopathies, AFM Funding details: Horizon 2020 Framework Programme, H2020, 666869 Funding details: Agence Nationale de la Recherche, ANR Funding details: Centre National de la Recherche Scientifique, CNRS Funding details: Seventh Framework Programme, FP7 Funding details: Olga Mayenfisch Stiftung Funding text 1: This work was supported by the EU FP7 contract Thyrage (grant number 666869 ), the AFM ; ANR grants Thrast and OLGA ; CNRS . Funding text 2: This work was supported by the EU FP7 contract Thyrage (grant number 666869), the AFM; ANR grants Thrast and OLGA; CNRS. LA - English DB - MTMT ER - TY - JOUR AU - Jócsák, Gergely AU - Kiss, Dávid Sándor AU - Tóth, István AU - Barany, Z AU - Zsarnovszky, Attila AU - Frenyó V., László TI - A zearalenon, mint mikotoxin káros hatásai az emlős szervezetben: az utóbbi évtizedek eredményeinek rövid áttekintése JF - MAGYAR ÁLLATORVOSOK LAPJA J2 - MAGY ALLATORVOSOK VL - 139 PY - 2017 IS - 1 SP - 55 EP - 64 PG - 10 SN - 0025-004X UR - https://m2.mtmt.hu/api/publication/3170837 ID - 3170837 AB - The authors present their study on the summarized effects of zearalenone (ZEA) on the mammalian neuroendocrine system. Oestrogen and oestrogen receptors play a key role in mammalian physiology. Endocrine disruptors, such as ZEA have the ability to interfere with hormonal regulatory pathways due to their oestrogenlike molecular structure. The aim of the present review is to discuss the best known effects of ZEA poisoning. ZEA is a well-known mycotoxin, usually found in contaminated unprocessed maize and other cereal kernel. The contamination begins at the growing area, however it can also spread during improper storage, causing a contamination in the feed. This is still a serious problem in animal husbandry and in the industrial production of meat. After ingestion, the toxin can easily get into the body. ZEA can directly induce apoptosis, thus causing cell loss in specific organs (mostly in the liver and the immune system) resulting in a decreased, weakened function. In addition to the cellular effects, ZEA also acts as endocrine disruptor, it alters the physiological neuroendocrine regulation, thus disrupting the physiological action of the organs requiring oestrogen modulation. ZEA has a serious impact on the production of the cellular components of the blood; the quality, and cellular quantity of the immune response; the homeostasis and the functions during detoxification of the liver and kidneys; the neuroendocrine organ functions (disrupting the regulative characteristics of specific parts of the hormonal milieu in the animals) and even on the central nervous system. Most importantly ZEA can interfere with the reproductive physiology of animals (due to the disruption on the neuroendocrine regulation), thus lowering the possible productivity of the livestock, causing major economic losses. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Jócsák, Gergely AU - Kiss, Dávid Sándor AU - Tóth, István AU - Goszleth, Gréta AU - Bartha, Tibor AU - Frenyó V., László AU - Horváth, Tamás AU - Zsarnovszky, Attila TI - Comparison of individual and combined effects of four endocrine disruptors on estrogen receptor beta transcription in cerebellar cell culture: The modulatory role of estradiol and triiodo-thyronine JF - INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH J2 - INT J ENV RES PUB HE VL - 13 PY - 2016 IS - 6 PG - 14 SN - 1661-7827 DO - 10.3390/ijerph13060619 UR - https://m2.mtmt.hu/api/publication/3089063 ID - 3089063 LA - English DB - MTMT ER - TY - GEN AU - Zsarnovszky, Attila AU - Frenyó, Vilmos László AU - Győrffy, Andrea AU - Kiss, Dávid Sándor AU - Scalise, JohnsonTrudy AU - Tóth, István TI - A hipotalamikus neuronális energiaszint szabályozásának vizsgálata: Az NTPDázok, mint lehetséges energia-regulátorok szerepe a pozitív gonadotropin feedback során. Regulation of neuronal energy levels in the hypothalamus: NTPDases as possible energy regulators of the positive gonadotrophin feedback TS - Regulation of neuronal energy levels in the hypothalamus: NTPDases as possible energy regulators of the positive gonadotrophin feedback PY - 2014 SP - 1 EP - 13 PG - 13 UR - https://m2.mtmt.hu/api/publication/24909847 ID - 24909847 N1 - http://real.mtak.hu/12618/1/81745_ZJ1.pdf LA - English DB - MTMT ER - TY - GEN AU - Bartha, Tibor AU - Frenyó, Vilmos László AU - Németh, Péter AU - Sótonyi, Péter AU - Zsarnovszky, Attila TI - Az energiaháztartást szabályzó hormonok hatásmechanizmusának vizsgálata a hypothalamusban: pajzsmirigyhormon, ösztrogén, leptin és ghrelin interakciók. Analysis of hypothalamic hormonal equilibrium in the regulation of energy balance: interactions between thyroid hormone, estrogen, leptin and ghrelin TS - Analysis of hypothalamic hormonal equilibrium in the regulation of energy balance: interactions between thyroid hormone, estrogen, leptin and ghrelin PY - 2012 SP - 1 EP - 19 PG - 19 UR - https://m2.mtmt.hu/api/publication/24909845 ID - 24909845 N1 - http://real.mtak.hu/12191/1/72186_ZJ1.pdf LA - Hungarian DB - MTMT ER -