@article{MTMT:31194217, title = {Endocrine Disruptors Induced Distinct Expression of Thyroid and Estrogen Receptors in Rat versus Mouse Primary Cerebellar Cell Cultures}, url = {https://m2.mtmt.hu/api/publication/31194217}, author = {Jócsák, Gergely and Ioja, Enikő and Kiss, Dávid Sándor and Tóth, István and Bárány, Zoltán Balázs and Bartha, Tibor and Frenyó V., László and Zsarnovszky, Attila}, doi = {10.3390/brainsci9120359}, journal-iso = {BRAIN SCI}, journal = {BRAIN SCIENCES}, volume = {9}, unique-id = {31194217}, year = {2019}, eissn = {2076-3425}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @article{MTMT:3393033, title = {Comparative Analysis of Zearalenone Effects on Thyroid Receptor Alpha (TR alpha) and Beta (TR beta) Expression in Rat Primary Cerebellar Cell Cultures}, url = {https://m2.mtmt.hu/api/publication/3393033}, author = {Kiss, Dávid Sándor and Ioja, E and Tóth, István and Bárány, Zoltán Balázs and Jócsák, Gergely and Bartha, Tibor and Horváth, Tamás and Zsarnovszky, Attila}, doi = {10.3390/ijms19051440}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {19}, unique-id = {3393033}, issn = {1661-6596}, year = {2018}, eissn = {1422-0067}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @article{MTMT:3278620, title = {Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum}, url = {https://m2.mtmt.hu/api/publication/3278620}, author = {Zsarnovszky, Attila and Kiss, Dávid Sándor and Jócsák, Gergely and Németh, Gábor László and Tóth, István and Horváth, Tamás}, doi = {10.1016/j.yfrne.2017.10.001}, journal-iso = {FRONT NEUROENDOCRIN}, journal = {FRONTIERS IN NEUROENDOCRINOLOGY}, volume = {48}, unique-id = {3278620}, issn = {0091-3022}, abstract = {Although the effects of phytoestrogens on brain function is widely unknown, they are often regarded as "natural" and thus as harmless. However, the effects of phytoestrogens or environmental pollutants on brain function is underestimated. Estrogen (17beta-estradiol, E2) and thyroid hormones (THs) play pivoltal roles in brain development. In the mature brain, these hormones regulate metabolism on cellular and organismal levels. Thus, E2 and THs do not only regulate the energy metabolism of the entire organism, but simultaneously also regulate important homeostatic parameters of neurons and glia in the CNS. It is, therefore, obvious that the mechanisms through which these hormones exert their effects are pleiotropic and include both intra- and intercellular actions. These hormonal mechanisms are versatile, and the experimental investigation of simultaneous hormone-induced mechanisms is technically challanging. In addition, the normal physiological settings of metabolic parameters depend on a plethora of interactions of the steroid hormones. In this review, we discuss conceptual and experimental aspects of the gonadal and thyroid hormones as they relate to in vitro models of the cerebellum.}, year = {2018}, eissn = {1095-6808}, pages = {23-36}, orcid-numbers = {Németh, Gábor László/0000-0003-1829-3457; Tóth, István/0000-0002-0168-4753} } @article{MTMT:27348520, title = {Comparative approaches to understanding thyroid hormone regulation of neurogenesis}, url = {https://m2.mtmt.hu/api/publication/27348520}, author = {Gothie, Jean-David and Demeneix, Barbara and Remaud, Sylvie}, doi = {10.1016/j.mce.2017.05.020}, journal-iso = {MOL CELL ENDOCRINOL}, journal = {MOLECULAR AND CELLULAR ENDOCRINOLOGY}, volume = {459}, unique-id = {27348520}, issn = {0303-7207}, year = {2017}, eissn = {1872-8057}, pages = {104-115} } @article{MTMT:3170837, title = {A zearalenon, mint mikotoxin káros hatásai az emlős szervezetben: az utóbbi évtizedek eredményeinek rövid áttekintése}, url = {https://m2.mtmt.hu/api/publication/3170837}, author = {Jócsák, Gergely and Kiss, Dávid Sándor and Tóth, István and Barany, Z and Zsarnovszky, Attila and Frenyó V., László}, journal-iso = {MAGY ALLATORVOSOK}, journal = {MAGYAR ÁLLATORVOSOK LAPJA}, volume = {139}, unique-id = {3170837}, issn = {0025-004X}, abstract = {The authors present their study on the summarized effects of zearalenone (ZEA) on the mammalian neuroendocrine system. Oestrogen and oestrogen receptors play a key role in mammalian physiology. Endocrine disruptors, such as ZEA have the ability to interfere with hormonal regulatory pathways due to their oestrogenlike molecular structure. The aim of the present review is to discuss the best known effects of ZEA poisoning. ZEA is a well-known mycotoxin, usually found in contaminated unprocessed maize and other cereal kernel. The contamination begins at the growing area, however it can also spread during improper storage, causing a contamination in the feed. This is still a serious problem in animal husbandry and in the industrial production of meat. After ingestion, the toxin can easily get into the body. ZEA can directly induce apoptosis, thus causing cell loss in specific organs (mostly in the liver and the immune system) resulting in a decreased, weakened function. In addition to the cellular effects, ZEA also acts as endocrine disruptor, it alters the physiological neuroendocrine regulation, thus disrupting the physiological action of the organs requiring oestrogen modulation. ZEA has a serious impact on the production of the cellular components of the blood; the quality, and cellular quantity of the immune response; the homeostasis and the functions during detoxification of the liver and kidneys; the neuroendocrine organ functions (disrupting the regulative characteristics of specific parts of the hormonal milieu in the animals) and even on the central nervous system. Most importantly ZEA can interfere with the reproductive physiology of animals (due to the disruption on the neuroendocrine regulation), thus lowering the possible productivity of the livestock, causing major economic losses.}, year = {2017}, pages = {55-64}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @article{MTMT:3089063, title = {Comparison of individual and combined effects of four endocrine disruptors on estrogen receptor beta transcription in cerebellar cell culture: The modulatory role of estradiol and triiodo-thyronine}, url = {https://m2.mtmt.hu/api/publication/3089063}, author = {Jócsák, Gergely and Kiss, Dávid Sándor and Tóth, István and Goszleth, Gréta and Bartha, Tibor and Frenyó V., László and Horváth, Tamás and Zsarnovszky, Attila}, doi = {10.3390/ijerph13060619}, journal-iso = {INT J ENV RES PUB HE}, journal = {INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH}, volume = {13}, unique-id = {3089063}, issn = {1661-7827}, year = {2016}, eissn = {1660-4601}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @techreport{MTMT:24909847, title = {A hipotalamikus neuronális energiaszint szabályozásának vizsgálata: Az NTPDázok, mint lehetséges energia-regulátorok szerepe a pozitív gonadotropin feedback során. Regulation of neuronal energy levels in the hypothalamus: NTPDases as possible energy regulators of the positive gonadotrophin feedback}, url = {https://m2.mtmt.hu/api/publication/24909847}, author = {Zsarnovszky, Attila and Frenyó, Vilmos László and Győrffy, Andrea and Kiss, Dávid Sándor and Scalise, JohnsonTrudy and Tóth, István}, unique-id = {24909847}, year = {2014}, pages = {1-13} } @techreport{MTMT:24909845, title = {Az energiaháztartást szabályzó hormonok hatásmechanizmusának vizsgálata a hypothalamusban: pajzsmirigyhormon, ösztrogén, leptin és ghrelin interakciók. Analysis of hypothalamic hormonal equilibrium in the regulation of energy balance: interactions between thyroid hormone, estrogen, leptin and ghrelin}, url = {https://m2.mtmt.hu/api/publication/24909845}, author = {Bartha, Tibor and Frenyó, Vilmos László and Németh, Péter and Sótonyi, Péter and Zsarnovszky, Attila}, unique-id = {24909845}, year = {2012}, pages = {1-19} }