TY - JOUR AU - Zhu, Yuan AU - Wang, Haiqiao AU - Adu-Frimpong, Michael AU - Zou, Zhihui AU - Jin, Zhou AU - Zhang, Peiyao AU - Xue, Yuanyuan AU - Li, Shuang AU - Xu, Ying AU - Yu, Jiangnan AU - Xu, Ximing TI - HA/PLA Composite Nanoparticles for Enhanced Oral Bioavailability of Capsaicin: Fabrication, Characterization and in vitro-in vivo Evaluation JF - CHEMISTRYSELECT J2 - CHEMISTRYSELECT VL - 9 PY - 2024 IS - 4 PG - 11 SN - 2365-6549 DO - 10.1002/slct.202303080 UR - https://m2.mtmt.hu/api/publication/34593186 ID - 34593186 AB - In this paper, hydroxylapatite (HA) nanoparticles were constructed through the ultrasound-assisted dispersion method. Using scanning electron microscopy (SEM), we studied the preparation methods of HA nanoparticles, and spherical HA nanoparticles with a size of about 50 nm were prepared. Besides, we constructed the HA/PLA composite nanoparticles with polylactic acid (PLA) as the material. The effects of different composite proportions on the HA/PLA composite nanoparticles were investigated before Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscope (TEM), and SEM, were applied to preliminary evaluate the effects of the above-mentioned nanoparticles on capsaicin release. Through an in vitro study, we found that the release rate of the drug could be influenced by various release media and different compounding ratios (of HA and PLA). Furthermore, the pharmacokinetics study of capsaicin powder and capsaicin-loaded HA/PLA composite nanoparticles demonstrated marked increased Cmax, prolongation of Tmax to 8 h, increased T1/2 and mean retention time (MRT) by 6.7 and 5.6 times respectively, coupled with 9240.2 % increase in relative bioavailability. Of note, HA/PLA composite nanoparticles showed good biocompatibility and exhibited good long-term controlled release carriers, coupled with the ability to improve the solubility and bioavailability of a lipophilic drug.Spheroid hydroxylapatite (HA) nanoparticles were constructed with the ultrasound-assisted dispersion method, with polylactic acid (PLA) as the material, HA/PLA composite nanoparticles with different composite ratios were fabricated successfully and investigated with Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscope (TEM) and scanning electron microscopy (SEM). Capsaicin was used as a model drug to investigate the release effect of HA/PLA composite nanoparticles. image LA - English DB - MTMT ER - TY - JOUR AU - Akbar, Muhammad Usman AU - Akbar, Arslan AU - Saddozai, Umair Ali Khan AU - Khan, Malik Ihsan Ullah AU - Zaheer, Muhammad AU - Badar, Muhammad TI - A multivariate metal-organic framework based pH-responsive dual-drug delivery system for chemotherapy and chemodynamic therapy JF - MATERIALS ADVANCES J2 - MATER ADV VL - 4 PY - 2023 IS - 22 SP - 5653 EP - 5667 PG - 15 SN - 2633-5409 DO - 10.1039/d3ma00389b UR - https://m2.mtmt.hu/api/publication/34252523 ID - 34252523 N1 - Gomal Center of Biochemistry and Biotechnology, Gomal University, Dera Ismail Khan, 29050, Pakistan Department of Chemistry and Chemical Engineering, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences (LUMS), Lahore, 54792, Pakistan Department of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, 54000, Pakistan Export Date: 15 January 2024 Correspondence Address: Zaheer, M.; Department of Chemistry and Chemical Engineering, Pakistan; email: muhammad.zaheer@lums.edu.pk Correspondence Address: Badar, M.; Gomal Center of Biochemistry and Biotechnology, Pakistan; email: mbadar@gu.edu.pk AB - Combination therapy has emerged as a promising strategy due to its synergistic therapeutic pathways that enhance anticancer efficacy and limit the emergence of drug resistance. In this work, MIL-88B type multivariate (MTV-1) nanocarriers based on a mixed linker (1,4-benzenedicarboxylic acid and biphenyl-4,4 '-dicarboxylic acid) and metals (iron and cobalt) were synthesized. The presence of the distinct linkers modified the pore makeup of MTV-1 and facilitated the co-encapsulation of two anticancer drugs of varying molecular sizes: 5-fluorouracil (5-FU) and curcumin (CUR). The drug loading measurements on MTV-1@5-FU + CUR represented a loading capacity of 15.9 wt% for 5-FU and 9.3 wt% for CUR, respectively. They further exhibited a pH-responsive drug release pattern with higher concentrations of 5-FU and CUR released at pH 5.5 (simulating cancer microenvironment) compared to pH 7.4 (physiological environment). Moreover, we also demonstrated that MTV-1 MOFs, due to the presence of mixed valence metal ions, could exhibit peroxidase-like activity and catalyze H2O2 decomposition to produce OH radicals for chemodynamic therapy. Cell cytotoxicity assays exhibited significant inhibitory effects of MTV-1@5-Fu + CUR against HepG2 cells with an IC50 of 78.7 mu g mL-1. With dual-drug loading, pH-responsive release, and chemodynamic therapy, MTV-1 shows excellent potential for multifunctional anticancer treatment.By combining two different ligands and metals, MOFs can be fine-tuned for effective encapsulation and delivery of two anticancer drugs. LA - English DB - MTMT ER - TY - JOUR AU - Fatmi, S. AU - Taouzinet, L. AU - Skiba, M. AU - Iguer-Ouada, M. TI - CAMPTOTHECIN: SOLUBILITY, IN-VITRO DRUG RELEASE, AND EFFECT ON HUMAN RED BLOOD CELLS AND SPERM COLD PRESERVATION JF - CRYOLETTERS J2 - CRYOLETTERS VL - 44 PY - 2023 IS - 2 SP - 89 EP - 99 PG - 11 SN - 0143-2044 DO - 10.54680/fr23210110712 UR - https://m2.mtmt.hu/api/publication/34083976 ID - 34083976 N1 - Export Date: 1 August 2023 CODEN: CRLED Correspondence Address: Taouzinet, L.; Associated Laboratory in Marine Ecosystems and Aquaculture, Algeria; email: lamia.taouzinet@crtaa.univ-bejaia.dz LA - English DB - MTMT ER - TY - JOUR AU - Hong, T. AU - Wan, M. AU - Lv, S. AU - Peng, L. AU - Zhao, Y. TI - Metal-phenolic coated rod-like silica nanocarriers with pH responsiveness for pesticide delivery JF - COLLOIDS AND SURFACES A : PHYSICOCHEMICAL AND ENGINEERING ASPECTS J2 - COLLOID SURFACE A VL - 662 PY - 2023 SN - 0927-7757 DO - 10.1016/j.colsurfa.2023.130989 UR - https://m2.mtmt.hu/api/publication/34083975 ID - 34083975 N1 - Export Date: 1 August 2023 CODEN: CPEAE Correspondence Address: Peng, L.; National & Local Joint Engineering Research Center for Applied Technology of Hybrid Nanomaterials, China; email: plc@henu.edu.cn LA - English DB - MTMT ER - TY - JOUR AU - Parsana, Nildhara AU - Kumar, Sugam AU - Aswal, Vinod K. AU - El Seoud, Omar AU - Malek, Naved I. TI - Self-Healable, Injectable, and Conductive Supramolecular Eutectogel for the Encapsulation and Sustained Release of the Anticancer Drug Curcumin JF - ACS APPLIED ENERGY MATERIALS J2 - ACS APPL ENERGY MATERIALS VL - 1 PY - 2023 IS - 1 SP - 380 EP - 393 PG - 14 SN - 2574-0962 DO - 10.1021/acsaenm.2c00095 UR - https://m2.mtmt.hu/api/publication/33863372 ID - 33863372 AB - The intriguing properties such as high environmental compatibility of supramolecular gels made solely through reversible noncovalent interactions are of recent interest. To offer proof of concept for the new-age sustainable materials, herein we have designed the self-healable, injectable, and ionic conductive supramolecular eutectogel in natural deep eutectic solvent (NADES). The studied eutectogels were prepared by dissolving the pharmaceutically active cetylpyridinium chloride (C16PyCl) and cetylpyridinium bromide (C16PyBr) in the NADES. The NADES was formed by interacting choline chloride (ChCl) with mono-, di-, and trimeric acids, i.e., formic acid (FA), oxalic acid (OA), and citric acid (CA) through hydrogen bonding. The gelation kinetics of the eutectogel was assessed using turbidity measurement as a function of time, whereas the morphology and mechanical properties were assessed using scanning electron microscopy (SEM) and rheology. To further verify the shape and size of the aggregate within the eutectogel, small angle neutron scattering (SANS) was performed. The eutectogel offers excellent self-healing, injectable, and ionic conductive properties as well as excellent antimicrobial properties, and offers high encapsulation efficiency for curcumin. The sustained release characteristics and release kinetics of curcumin was also investigated. Gel phases, in particular, show high colloidal forces, which, along with their environmentally benign nature, make them a great candidate not only for biomedical applications but also for the industries that require high performance with minimal environmental impact. LA - English DB - MTMT ER - TY - JOUR AU - Qu, Haibin AU - Wu, Songgu AU - Gong, Junbo TI - A sustainable and smart fungicide release platform through cocrystal nanocapsules for improved utilization rate and environmental safety JF - CHEMICAL ENGINEERING JOURNAL J2 - CHEM ENG J VL - 473 PY - 2023 PG - 13 SN - 1385-8947 DO - 10.1016/j.cej.2023.145284 UR - https://m2.mtmt.hu/api/publication/34593187 ID - 34593187 AB - Pesticides have always been restricted by environmental factors and utilization rate. Smart delivery systems are important to modify pesticides and improve utilization rate, but the economic and environmental risks of the carriers limit their practical applications. Here, responsive release nanocapsules were constructed with metalphenolic networks and pyraclostrobin - thiophanate-methyl (PYR-TM) cocrystal core to modify the poor physicochemical properties and safety of pesticides. PYR-TM was prepared by sustainable mechanochemical method and deposited by metal-phenolic networks in water, producing the PYR-TM@TA-Cu nanocapsules. The crystal structure and DFT calculations proved that TM improved the photostability of PYR by 75.7-fold through competitive energy absorption of photon and molecular conformation modulation. With a loading capacity up to 91.2%, PYR-TM@TA-Cu exhibited pH-responsive release behavior triggered by acidic conditions, which showed that 43.6%, 51.4%, 62.4% and 81.6% of encapsulated PYR were released at pH 7.9, 6.2, 5.3, and 4.0, respectively. Additionally, PYR-TM@TA-Cu exhibited favorable fungicidal activity (EC50 = 0.123 mg/L) in controlling Botrytis cinerea. The greenhouse control efficiency of fungal infection was enhanced from12.0% to 70.7% by PYRTM@TA-Cu after 7 days spraying. The coating of metal-phenolic network improved the washing persistence of the pesticides from 51.26% to 79.88%, the security for zebrafish by 42-fold, and decreased the leaching potential of the pesticides. Meanwhile, PYR-TM@TA-Cu showed no phytotoxicity on the growth of corn and cucumber plants. Overall, this study provides insight into efficient and sustainable agricultural production with the construction of an eco-friendly nanocapsules platform by cocrystal engineering strategy. LA - English DB - MTMT ER - TY - JOUR AU - Zhao, Ning AU - Zhu, Li AU - Liu, Meichen AU - He, Liangheng AU - Xu, Hanhong AU - Jia, Jinliang TI - Enzyme-Responsive Lignin Nanocarriers for Triggered Delivery of Abamectin to Control Plant Root-Knot Nematodes (Meloidogyne incognita) JF - JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY J2 - J AGR FOOD CHEM VL - 71 PY - 2023 IS - 8 SP - 3790 EP - 3799 PG - 10 SN - 0021-8561 DO - 10.1021/acs.jafc.2c07466 UR - https://m2.mtmt.hu/api/publication/33863371 ID - 33863371 N1 - State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou, 510642, China Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China Export Date: 1 August 2023 CODEN: JAFCA Correspondence Address: Xu, H.; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, China; email: hhxu@scau.edu.cn Correspondence Address: Jia, J.; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, China; email: jiajinliang@scau.edu.cn AB - Intelligently responsive nanoparticles can improve insecticidal activity against target organisms and reduce the use of pesticides in agriculture. In this study, enzymatic hydrolysis lignin (EHL) nanocarriers with enzyme responsiveness were successfully prepared by electrostatic interaction, and abamectin (Abm)-loaded EHL-based nanoparticles (Abm@L-CL) were investigated. The release behavior of Abm@L-CL nanoparticles showed that Abm was released rapidly in the presence of cellulase and pectinase but slowly under natural conditions. The insecticidal activity of Abm@L-CL treatment (LC50 = 0.68 mu g/mL) against nematodes (Meloidogyne incognita) was significantly more effective than that of original Abm treatment (LC50 = 1.32 mu g/mL). The mortality rate of Abm@L-CL was more than 90% by applying the same dose of Abm after 12 h. The bioactivity of Abm@L-CL against root-knot nematodes was 1.7-fold greater than that of Abm. The result of fluorescence indicated that nanoparticles could enter the intestinal tract through the oral cavity of nematodes and achieve obvious gastric toxicity. Furthermore, the enzyme-controlled lignin-based Abm nanocarriers could penetrate the tomato root near the elongation zone. This study provided intelligent enzyme-responsive nanocarriers for efficient management of soil-borne diseases and pests in green agricultural inputs. LA - English DB - MTMT ER - TY - JOUR AU - Almawash, Saud AU - Quadir, Sheikh Shahnawaz AU - Al Saqr, Ahmed AU - Sharma, Gajanand AU - Raza, Kaisar TI - Dual Delivery of Fluticasone Propionate and Levocetirizine Dihydrochloride for the Management of Atopic Dermatitis Using a Microemulsion-Based Topical Gel JF - ACS OMEGA J2 - ACS OMEGA VL - 7 PY - 2022 IS - 9 SP - 7696 EP - 7705 PG - 10 SN - 2470-1343 DO - 10.1021/acsomega.1c06393 UR - https://m2.mtmt.hu/api/publication/32959458 ID - 32959458 N1 - Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, 11961, Saudi Arabia Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Rajasthan, Ajmer, 305817, India Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj, 11942, Saudi Arabia University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India Export Date: 24 September 2022 Correspondence Address: Raza, K.; Department of Pharmacy, Bandarsindri, Rajasthan, India; email: drkaisar@curaj.ac.in AB - The current study investigates the potential for topical delivery of a fluticasone propionate (FP) and levocetirizine dihydrochloride (CTZ)-loaded microemulsion (ME) for the management of atopic dermatitis. Various microemulsion components were chosen based on their solubility and emulsification capabilities, and the ternary phase diagram was constructed. A total of 12 microemulsion formulations were screened for various attributes like vesicle size, polydispersity index, zeta-potential, percent transmittance, density, and pH. The average globule size and zeta-potential of FP and levocetirizine-containing ME were 52.12 nm and -2.98 zeta-potential, respectively. Transmission electron microscopy confirmed the spherical nature of the globules. The developed system not only controlled the release of both drugs but also enhanced the efficacy of the drugs on a rodent model. Histopathological studies confirmed the safety of the developed system. The present findings provide evidence for a scalable and simpler approach for the management of atopic dermatitis. LA - English DB - MTMT ER - TY - JOUR AU - Jiang, Junwen AU - Wu, Huihua AU - Zou, Zhenmin TI - In vitro and in vivo evaluation of a novel lidocaine-loaded cubosomal gel for prolonged local anesthesia JF - JOURNAL OF BIOMATERIALS APPLICATIONS J2 - J BIOMATER APPL VL - 37 PY - 2022 IS - 2 SP - 315 EP - 323 PG - 9 SN - 0885-3282 DO - 10.1177/08853282221087346 UR - https://m2.mtmt.hu/api/publication/32959459 ID - 32959459 N1 - Export Date: 24 September 2022 CODEN: JBAPE Correspondence Address: Wu, H.; Anesthesiology Department, Jiangxi, China; email: whhjdz2021@163.com AB - Marketed lidocaine dosage forms (such as ointment, gels, and injections) used to manage acute and chronic pain showed a short duration of action (<2 h). In this study, a lidocaine-loaded cubosomal gel was prepared to sustain the release of lidocaine to prolong the local anesthetic effect (high drug retention in the skin). Lidocaine-loaded cubosomal gels were prepared by melt emulsification and sonication using Pluronic F I 27 and DL-alpha-nnonoolein (at different levels). The cubosomal gels were characterized by morphology, size, zeta potential, entrapment efficacy, assay, viscosity, pH, and texture profiles. Ex vivo lidocaine permeation and retention studies were performed using Sprague-Dawley rat skin. Transmission electron microscopy images confirmed the bi-continuous liquid crystalline phase with a honeycomb cubosome structure. The cubosomal particle size (103-227 nm), viscosity (13,524-1 5,627cp), and entrapment efficacy (78.4-94.7%) increase with the level of monoolein. The ex-vivo permeation study showed a biphasic release pattern, with lidocaine cleared from ointment within 4 h (97.9% cumulative release), while cubosomal gels showed sustained release up to 24 h (53.33-98.86% cumulative release). A skin retention study demonstrated that cubosomes can increase (up to 28-fold) the lidocaine content in the skin (4.56 mg) compared to ointment (0.19 mg). A rabbit skin irritation study showed no sign of irritation after the application of cubosomal gel. In the radiant heat tail-flick study, the local anesthetic effect of lidocaine from the cubosomal gel was sustained for up to 16 h with I.43-fold higher efficacy than marketed ointment. In conclusion, the study demonstrated the potential of cubosomal nanoparticle-laden gel to sustain the release of lidocaine for prolonging local anesthetic effects for pain management. LA - English DB - MTMT ER - TY - JOUR AU - Liang, W. AU - Zhang, J. AU - Wurm, F.R. AU - Wang, R. AU - Cheng, J. AU - Xie, Z. AU - Li, X. AU - Zhao, J. TI - Lignin-based non-crosslinked nanocarriers: A promising delivery system of pesticide for development of sustainable agriculture JF - INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES J2 - INT J BIOL MACROMOL VL - 220 PY - 2022 SP - 472 EP - 481 PG - 10 SN - 0141-8130 DO - 10.1016/j.ijbiomac.2022.08.103 UR - https://m2.mtmt.hu/api/publication/33109113 ID - 33109113 N1 - Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, 310058, China Institute for the Control of Agrochemicals, Ministry of Agriculture, Beijing, 100125, China Sustainable Polymer Chemistry, Department of Molecules and Materials, MESA+ Institute for Nanotechnology, Faculty of Science and Technology, Universiteit Twente, PO Box 217, Enschede, 7500 AE, Netherlands Economic Specialty Technology Extension Center, Lanxi, 321100, China Export Date: 24 September 2022 CODEN: IJBMD Correspondence Address: Li, X.; Institute for the Control of Agrochemicals, China; email: lixianbin@agri.gov.cn LA - English DB - MTMT ER - TY - JOUR AU - Lin, Wen AU - Li, Yinke AU - Shi, Qiongzhi AU - Liao, Xiangru AU - Zeng, Yuan AU - Tian, Wei AU - Xie, Xiangyang AU - Liu, Hui TI - Preparation and evaluation of bilayer-core osmotic pump tablets contained topiramate JF - PLOS ONE J2 - PLOS ONE VL - 17 PY - 2022 IS - 2 PG - 22 SN - 1932-6203 DO - 10.1371/journal.pone.0264457 UR - https://m2.mtmt.hu/api/publication/32959457 ID - 32959457 N1 - Department of Clinical Laboratory, Huangshi Love & Health Hospital of Hubei Province, Hubei, Huangshi, China Department of Pharmacy, General Hospital of Central Theater of the PLA, Hubei, Wuhan, China Export Date: 24 September 2022 CODEN: POLNC Correspondence Address: Xie, X.; Department of Pharmacy, Hubei, China; email: xxysypu@163.com AB - Topiramate (TPM) was an antiepileptic agent commonly used in clinical. Studies showed that an oral preparation of TPM with extended-release manner could bring some benefits for epileptics. In this paper, controlled release push-pull osmotic pump (PPOP) tablets of sparingly water-soluble TPM were successfully prepared. This bi-layer tablet core mainly consisted of sodium chloride as osmotic promoting agent and polyethylene oxide as suspending and pushing agents. The influences of osmotic agents, pushing agents and the compositions of coating membrane on TPM release profiles were evaluated. An optimal formulation of TPM-PPOP was obtained through single-factor experiments. In vitro release tests showed that the optimum formulation could release TPM at an approximate zero-order rate up to 8 h. Pharmacokinetic behaviors of TPM-PPOP tablets were evaluated and compared with the immediate release capsules after an oral single dose in beagle dogs. Pharmacokinetics results demonstrated that the TPM-PPOP tablet was able to provide a prolonged release of TPM with longer t(max) and mean residence time. Lower fluctuations of drug plasma levels could also be achieved with TPM-PPOP tablets. These results suggested that sparely water-soluble drugs as TPM can be designed to PPOP for efficacy and safety use. LA - English DB - MTMT ER - TY - JOUR AU - Parsaei, Mozhgan AU - Akhbari, Kamran TI - MOF-801 as a Nanoporous Water-Based Carrier System for In SituEncapsulation and Sustained Release of 5-FU for Effective Cancer Therapy JF - INORGANIC CHEMISTRY J2 - INORG CHEM VL - 61 PY - 2022 IS - 15 SP - 5912 EP - 5925 PG - 14 SN - 0020-1669 DO - 10.1021/acs.inorgchem.2c00380 UR - https://m2.mtmt.hu/api/publication/32959456 ID - 32959456 N1 - Export Date: 24 September 2022 CODEN: INOCA Correspondence Address: Akhbari, K.; School of Chemistry, Iran; email: akhbari.k@khayam.ut.ac.ir AB - Nanoporous metal-organic frameworks (MOFs)have been gaining a reputation for their drug delivery applications.In the current work, MOF-801 was successfully prepared by afacile, cost-efficient, and environmentally friendly approachthrough the reaction of ZrCl4and fumaric acid as organic linkersto deliver 5-fluorouracil (5-FU). The prepared nanostructure wasfully characterized by a series of analytical techniques includingFourier transform infrared spectroscopy, powder X-ray diffraction,field-emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, UV-vis spectroscopy,1H NMR spectroscopy,thermogravimetric analysis, high-performance liquid chromatog-raphy, and Brunauer-Emmett-Teller analysis. MOF-801 could beused for the delivery of the anticancer drug 5-FU due to its highsurface area, suitable pore size, and biocompatible ingredients. Based on in vitro loading and release studies, a high 5-FU loadingcapacity and pH-dependent drug release behavior were observed. Moreover, the interactions between the structure of MOFs and 5-FU were investigated through Monte Carlo simulation calculations. An in vitro cytotoxicity test was done, and the results indicatedthat 5-FU@MOF-801 was more potent than 5-FU on SW480 cancerous cells, indicating the highlighted role of this drug deliverysystem. Finally, the kinetics of drug release was investigated. LA - English DB - MTMT ER - TY - JOUR AU - Prusty, A. AU - Gupta, B.K. AU - Mishra, A. TI - Formulation and In Vivo Evaluation of Pharmacokinetics Parameters of Extended Release Matrix Tablet Containing Drug Benidipine Hydrochloride by Using PK Solver Software JF - RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY J2 - RES J PHAR TECH VL - 15 PY - 2022 IS - 11 SP - 4924 EP - 4930 PG - 7 SN - 0974-3618 DO - 10.52711/0974-360X.2022.00827 UR - https://m2.mtmt.hu/api/publication/34083978 ID - 34083978 N1 - Export Date: 1 August 2023 Correspondence Address: Prusty, A.; Department of Pharmaceutics, Puri. Odisha, India; email: amareshprusty@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Xie, Zhengang AU - Liang, Wenlong AU - Xiong, Qiuyu AU - Zhao, Yanyan AU - Cheng, Jingli AU - Li, Xianbin AU - Zhao, Jinhao TI - Acetalated dextran microparticles for the smart delivery of pyraclostrobin to control Sclerotinia diseases JF - CARBOHYDRATE POLYMERS J2 - CARBOHYD POLYM VL - 291 PY - 2022 PG - 11 SN - 0144-8617 DO - 10.1016/j.carbpol.2022.119576 UR - https://m2.mtmt.hu/api/publication/32959455 ID - 32959455 N1 - Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, 310058, China China National Tea Museum, Hangzhou, 310013, China Institute for the Control of Agrochemicals, Ministry of Agriculture and Rural Affairs, Beijing, 100125, China Export Date: 24 September 2022 CODEN: CAPOD Correspondence Address: Li, X.; Institute for the Control of Agrochemicals, China; email: lixianbin@agri.gov.cn AB - Dextran has emerged as a promising biopolymer carrier for controlled release formulations of pesticides. In this study, pH-sensitive acetalated dextran microparticles (Pyr@Ac-Dex) are prepared to encapsulate and control the release of pyraclostrobin (Pyr). In vitro fungicidal activity experiments showed that the prepared Pyr@Ac-Dex particles show comparable fungicidal ability against S. sclerotiorum compared to that of Pyr technical. In a 10 -day pot experiment, the control efficacy of the Pyr@Ac-Dex treatment against S. sclerotiorum (77.1%) is signif-icantly higher than that of Pyr emulsifiable concentrate (Pyr EC) treatment (42.4%). Photodegradation experi-ments show that compared to Pyr technical, Pyr@Ac-Dex doubles the half-life of Pyr in water. Acute toxicity experiments show that Pyr@Ac-Dex significantly reduced the acute exposure toxicity of Pyr to zebrafish. This study provides an environmentally friendly, feasible, and sustainable strategy for plant disease management. LA - English DB - MTMT ER - TY - JOUR AU - Elmas, Aykut AU - Akyuz, Guliz AU - Bergal, Ayhan AU - Andac, Muberra AU - Andac, Omer TI - Enhanced Analytic Approach for Describing pH Triggered Fast Drug Release Systems JF - CURRENT DRUG DELIVERY J2 - CURR DRUG DELIV VL - 18 PY - 2021 IS - 8 SP - 1118 EP - 1124 PG - 7 SN - 1567-2018 DO - 10.2174/1567201818999210112181853 UR - https://m2.mtmt.hu/api/publication/32394319 ID - 32394319 N1 - Department of Nanoscience and Nanotechnology, Ondokuz Mayis University, Kurupelit, Samsun, 55139, Turkey De-partment of Chemistry, Ondokuz Mayis University, Kurupelit, Samsun, 55139, Turkey Export Date: 24 September 2022 Correspondence Address: Elmas, A.; Department of Nanoscience and Nanotechnology, Kurupelit, Turkey; email: aykutdiamond@gmail.com AB - Background: pH sensitive dendrimers attached to nanocarriers, as one of the drug release systems, have become quite popular due to their ease of manufacture in experimental conditions and the ability to generate fast drug release in the targeted area. This kind of fast release behavior cannot be represented properly in most of the existing kinetic mathematical models. Besides, these models have either no pH dependence or pH dependence added separately. Therefore, they remained one dimensional. Objective: The aim of this study was to establish the proper analytic equation to describe the fast release of drugs from pH sensitive nanocarrier systems, and to combine it with the pH dependent equation for to establish a two-dimensional model for whole system. Methods: We used four common kinetic models for the comparison and we fitted them to the release data. As a result, only Higuchi and Korsmeyer-Peppas models show acceptable suitable results. None of these models have pH dependence. To get a better description for pH triggered fast release, we observed the behavior of the slope angle of the release curve. Then we proposed a new analytic equation by using relation between the slope angle and time. Result: By adding a pH dependent equation, we assumed the drug release is "on" or "off" above/below specific pH value and we modified a step function to get a desired behavior. Conclusion: Our new analytic model shows good fitting, not only one-dimensional time dependent release, but also two-dimensional pH dependent release, that provides a useful analytic model to represent release profiles of pH sensitive fast drug release systems. LA - English DB - MTMT ER - TY - JOUR AU - Fatmi, Sofiane AU - Taouzinet, Lamia AU - Lahiani-Skiba, Malika AU - Skiba, Mohamed AU - Iguer-Ouada, Mokrane TI - New Formulation and Evaluation of Camptothecin Encapsulated and/or Dispersed Suppository JF - ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY J2 - ANTI-CANCER AGENT ME VL - 21 PY - 2021 IS - 6 SP - 1183 EP - 1190 PG - 8 SN - 1871-5206 DO - 10.2174/1871520620666200903150635 UR - https://m2.mtmt.hu/api/publication/32394323 ID - 32394323 N1 - Department of Processes Engineering, Faculty of Technology, Technology Pharmaceutical Laboratory, Université de Bejaia, Bejaia, 06000, Algeria Faculty of Nature and Life Sciences, Associated Laboratory in Marine Ecosystems and Aquaculture, Université de Bejaia, Bejaia, 06000, Algeria Technology Pharmaceutical and Bio Pharmaceutics Laboratory, UFR Medicine and Pharmacy, Rouen University, 22 Blvd. Gambetta, Rouen, 76183, France Cited By :2 Export Date: 24 September 2022 Correspondence Address: Fatmi, S.; Department of Processes Engineering, Algeria; email: fatmi.sofiane@gmail.com AB - Background: Camptothecin is known for its potent anticancer activity. However, its optimal activity is reduced due to its low solubility and stability in biological media.Objective: The aim of the present study is to design and characterize a Camptothecin (CPT) suppository formulation.Methods: Rectal suppositories of camptothecin alone, encapsulated with Cyclodextrin (CD) and in the ternary system (CPT encapsulated with cyclodextrin and dispersed in Polyethylene Glycol (PEG) 6000) were prepared using various hydrophobic and hydrophilic polymeric bases as semi-synthetic glyceride (Suppocire (R) AM Pellets) and Polyethylene Glycols (PEGs) mixtures. Formulations were evaluated by various parameters like weight variation, drug content, hardness and liquefaction time. In vitro release study was performed in USP type I apparatus using phosphate buffer pH 7.2 as dissolution media.Results: Suppositories were within the permissible range of all physical parameters. In vitro drug released from water soluble base (PEG) was greater than that from oil soluble base with ninety percent (90%) of drug dissolution. It was also established that drug release from various formulations was by diffusion mechanism, according to the Higuchi's equation.Conclusion: This new formulation offers a new approach to colorectal cancer treatment by offering an alternative and simple drug administration route. LA - English DB - MTMT ER - TY - JOUR AU - Liao, Lieqiang AU - Jia, Xinjian AU - Lou, Haoxiang AU - Zhong, Jinlian AU - Liu, Huijin AU - Ding, Shunming AU - Chen, Chao AU - Hong, Sanguo AU - Luo, Xuzhong TI - Supramolecular gel formation regulated by water content in organic solvents: self-assembly mechanism and biomedical applications JF - RSC ADVANCES J2 - RSC ADV VL - 11 PY - 2021 IS - 19 SP - 11519 EP - 11528 PG - 10 SN - 2046-2069 DO - 10.1039/d1ra00647a UR - https://m2.mtmt.hu/api/publication/32394322 ID - 32394322 N1 - Key Laboratory of Jiangxi Province for Environment and Energy Catalysis, College of Chemistry, Nanchang University, Nanchang, 330031, China Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, College of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, 341000, China Cited By :3 Export Date: 24 September 2022 CODEN: RSCAC Correspondence Address: Chen, C.; Key Laboratory of Jiangxi Province for Environment and Energy Catalysis, China; email: chaochen@ncu.edu.cn AB - As one of the most important and fruitful methods, supramolecular self-assembly has a significant advantage in designing and fabricating functional soft materials with various nanostructures. In this research, a low-molecular-weight gelator, N,N '-di(pyridin-4-yl)-pyridine-3,5-dicarboxamide (PDA-N4), was synthesized and used to construct self-assembled gels via a solvent-mediated strategy. It was found that PDA-N4 could form supramolecular gels in mixed solvents of water and DMSO (or DMF) at high water fraction (greater than or equal to 50%). By decreasing the water fraction from 50% to 30%, the gel, suspension and solution phases appeared successively, indicating that self-assembled aggregates could be efficiently modulated via water content in organic solvents. Moreover, the as-prepared PDA-N4 supramolecular gels not only displayed solid-like behavior, and pH- and thermo-reversible characteristics, but also showed a solution-gel-crystal transition with the extension of aging time. Further analyses suggested that both the crystal and gel had similar assembled structures. The intermolecular hydrogen bonding between amide groups and the pi-pi stacking interactions between pyridine groups played key roles in gel formation. Additionally, the release behavior of vitamin B12 (VB12) from PDA-N4 gel (H2O/DMSO, v/v = 90/10) was evaluated, and the drug controlled release process was consistent with a first-order release mechanism. The human umbilical venous endothelial cell culture results showed that the PDA-N4 xerogel has good cytocompatibility, which implied that the gels have potential biological application in tissue engineering and controlled drug release. LA - English DB - MTMT ER - TY - JOUR AU - Sharma, T. AU - Katare, O.P. AU - Jain, A. AU - Jain, S. AU - Chaudhari, D. AU - Borges, B. AU - Singh, B. TI - QbD-steered development of Biotin-Conjugated Nanostructured Lipid Carriers for Oral Delivery of Chrysin: Role of Surface Modification for Improving Biopharmaceutical Performance JF - COLLOIDS AND SURFACES B: BIOINTERFACES J2 - COLLOID SURFACE B VL - 197 PY - 2021 SN - 0927-7765 DO - 10.1016/j.colsurfb.2020.111429 UR - https://m2.mtmt.hu/api/publication/31883498 ID - 31883498 N1 - University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, 160 014, India National UGC-Centre of Nano Biomedical Applications, Panjab University, Chandigarh, 160014, India National Institute of Pharmaceutical Education and Research, Mohali160062, India Export Date: 20 February 2021 CODEN: CSBBE Correspondence Address: Singh, B.; University Institute of Pharmaceutical Sciences, India; email: bsbhoop@yahoo.com LA - English DB - MTMT ER - TY - JOUR AU - Xiao, Douxin AU - Cheng, Jingli AU - Liang, Wenlong AU - Sun, Lianli AU - Zhao, Jinhao TI - Metal-phenolic coated and prochloraz-loaded calcium carbonate carriers with pH responsiveness for environmentally-safe fungicide delivery JF - CHEMICAL ENGINEERING JOURNAL J2 - CHEM ENG J VL - 418 PY - 2021 PG - 9 SN - 1385-8947 DO - 10.1016/j.cej.2021.129274 UR - https://m2.mtmt.hu/api/publication/32394320 ID - 32394320 N1 - Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, 310058, China Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China Cited By :16 Export Date: 24 September 2022 CODEN: CMEJA Correspondence Address: Sun, L.; Institute of Drug Metabolism and Pharmaceutical Analysis, China; email: sunlianli@zju.edu.cn AB - The study of release mechanisms of pesticides with respect to environmental and biological factors facilitates improvement in pesticide use efficiencies and reduction in environmental risk. In this study, prochloraz (Pro), a highly effective fungicide, was loaded into starch-doped porous calcium carbonate (CaCO3), which was subsequently coated with a metal-phenolic film to prepare a pH-responsive delivery system (PC@TA/Cu). Results demonstrated that CaCO3 had a mean diameter of 1.55 mu m and its loading capacity for Pro was similar to 15.2%. PC@TA/Cu microparticles show good adhesion to rapeseed oil leaves and resisted washout with simulated rainwater. The cumulative release rate of PC@TA/Cu particles at pH = 3 was 1.63 times higher than that in nearneutral pH environment for 48 h. This pH-responsive release characteristic could be associated with the oxalic acid secreted by Sclerotinia sclerotiorum. The control effect against Sclerotinia disease with 100 mu g/mL of Pro content of PC@TA/Cu was 56.8% after 7 d, while that of Pro EW (emulsion in water) was 45.8%. Finally, biosafety tests showed a 4-fold reduction in the acute toxicity of PC@TA/Cu to zebrafish, compared to the that of Pro technical. The carrier (CaCO3@TA/Cu) had no significant effect on the growth of rapeseed oil seedlings. The results showed that the prepared PC@TA/Cu has long-lasting disease control capability and significantly reduced toxicity to non-target organisms, making it valuable for potential applications. LA - English DB - MTMT ER - TY - JOUR AU - Ahlawat, Jyoti AU - Neupane, Rabin AU - Deemer, Eva AU - Sreenivasan, Sreeprasad T. AU - Narayan, Mahesh TI - Chitosan-Ellagic Acid Nanohybrid for Mitigating Rotenone-induced Oxidative Stress JF - ACS APPLIED MATERIALS & INTERFACES J2 - ACS APPL MATER INTER VL - 12 PY - 2020 IS - 16 SP - 18964 EP - 18977 PG - 14 SN - 1944-8244 DO - 10.1021/acsami.9b21215 UR - https://m2.mtmt.hu/api/publication/31440104 ID - 31440104 N1 - Department of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, TX 79968, United States Department of Industrial Pharmacy, University of Toledo, Toledo, OH 43606, United States Department of Material Science and Engineering, University of Texas at El Paso, El Paso, TX 79968, United States Cited By :2 Export Date: 20 February 2021 Correspondence Address: Sreenivasan, S.T.; Department of Chemistry and Biochemistry, United States; email: sreenivasan@utep.edu Correspondence Address: Narayan, M.; Department of Chemistry and Biochemistry, United States; email: mnarayan@utep.edu AB - Antioxidants derived from nature, such as ellagic acid (EA), demonstrated high potency to mitigate neuronal oxidative stress and related pathologies, including Parkinson's disease. However, the application of EA is limited due to its toxicity at moderate doses and poor solubility, cellular permeability, and bioavailability. Here, we introduce a sustainably resourced, green nanoencasement strategy to overcome the limitations of EA and derive synergistic effects to prevent oxidative stress in neuronal cells. Chitosan, with its high biocompatibility, potential antioxidant properties, and flexible surface chemistry, was chosen as the primary component of the nanoencasement in which EA is immobilized. Using a rotenone model to mimic intracellular oxidative stress, we examined the effectiveness of EA and chitosan to limit cell death. Our studies indicate a synergistic effect between EA and chitosan in mitigating rotenone-induced reactive oxygen species death. Our analysis suggests that chitosan encapsulation of EA reduces the inherent cytotoxicity of the polyphenol (a known anticancer molecule). Furthermore, its encapsulation permits its delivery via a rapid burst phase and a relatively slow phase making the nanohybrid suitable for drug release over extended time periods. LA - English DB - MTMT ER - TY - JOUR AU - Lu, Tao AU - ten Hagen, Timo L. M. TI - A novel kinetic model to describe the ultra-fast triggered release of thermosensitive liposomal drug delivery systems JF - JOURNAL OF CONTROLLED RELEASE J2 - J CONTROL RELEASE VL - 324 PY - 2020 SP - 669 EP - 678 PG - 10 SN - 0168-3659 DO - 10.1016/j.jconrel.2020.05.047 UR - https://m2.mtmt.hu/api/publication/31694856 ID - 31694856 N1 - Cited By :1 Export Date: 17 February 2021 CODEN: JCREE Correspondence Address: ten Hagen, T.L.M.; Laboratory Experimental Oncology, Room Ee 0104a, POBox 1738, Netherlands; email: t.l.m.tenhagen@erasmusmc.nl Correspondence Address: Lu, T.; Laboratory Experimental Oncology, Erasmus MC, POBox 1738, Netherlands; email: tlupharmacy@hotmail.com Cited By :1 Export Date: 20 February 2021 CODEN: JCREE Correspondence Address: ten Hagen, T.L.M.; Laboratory Experimental Oncology, Room Ee 0104a, POBox 1738, Netherlands; email: t.l.m.tenhagen@erasmusmc.nl Correspondence Address: Lu, T.; Laboratory Experimental Oncology, Erasmus MC, POBox 1738, Netherlands; email: tlupharmacy@hotmail.com AB - Thermosensitive liposomes, as one of the stimuli-responsive drug delivery systems, receive growing attention, due to their ability to generate rapid and massive drug release in the heated area, and marginal release of contents in non-heated parts of the body. This typical triggered release behavior cannot be fitted adequately by most of the current mathematical kinetic models. The aim of this study was to establish the proper kinetic equation to describe the rapid release of drugs from trigger-sensitive drug delivery systems. We summarized all commonly used kinetic models mentioned in the literature and fitted the release data with these models, finding that only the Korsmeyer-Peppas and the Weibull models show acceptable fitting results. To better describe the release from thermosensitive liposomes with a size below 100 nm, we took Laplace pressure as a release-driving force and proposed a new equation that demonstrates improved fitting in liposomes ranging down to a size of 70 nm. Our new kinetic model shows desirable fitting, not only at the optimal temperature but also of releases within the whole release-temperature range, providing a useful kinetic model to describe release profiles of smaller nano-sized stimuli-responsive drug delivery systems. LA - English DB - MTMT ER - TY - JOUR AU - Porter, Simon L. AU - Coulter, Sophie M. AU - Pentlavalli, Sreekanth AU - Laverty, Garry TI - Pharmaceutical Formulation and Characterization of Dipeptide Nanotubes for Drug Delivery Applications JF - MACROMOLECULAR BIOSCIENCE J2 - MACROMOL BIOSCI VL - 20 PY - 2020 IS - 7 PG - 13 SN - 1616-5187 DO - 10.1002/mabi.202000115 UR - https://m2.mtmt.hu/api/publication/31440106 ID - 31440106 N1 - Cited By :2 Export Date: 20 February 2021 CODEN: MBAIB Correspondence Address: Laverty, G.; Biofunctional Nanomaterials Group, 97 Lisburn Road, Co Antrim, United Kingdom; email: garry.laverty@qub.ac.uk AB - Peptide nanotubes are promising materials for a variety of biomedical applications with ultrashort (<= 7 amino acids) forms providing particular promise for clinical translation. The manufacture of peptide nanotubes has, however, been associated with toxic organic solvents restricting clinical use. The purpose of this work is to formulate dipeptide nanotubes using mild techniques easily translated to industrial upscale and to characterize their physiochemical and biological properties. Phenylalanine-phenylalanine variants can be successfully formulated using distilled water as demonstrated here. Formulations are homogenous in shape (tubular), with apparent size (50-260 nm) and a zeta potential of up to +30 mV. L-(H2N-FF-COOH), and D-enantiomers (H2N-ff-COOH) demonstrate no toxicity against glioblastoma cells and are explored for ability to deliver a model hydrophilic molecule, sodium fluorescein, at pH 5.5 (tumor) and 7.4 (physiological). Peptide nanotubes loaded with >85% sodium fluorescein, demonstrate burst release characteristics, fitting the Weibull model of drug release. This research provides important data contributing to the pharmaceutical formulation of peptide nanotubes as drug delivery platforms for hydrophilic drugs. LA - English DB - MTMT ER - TY - JOUR AU - Lengyel, Miléna AU - Kállai-Szabó, Nikolett AU - Antal, Vince AU - Laki, András József AU - Antal, István TI - Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery JF - SCIENTIA PHARMACEUTICA J2 - SCI PHARM VL - 87 PY - 2019 IS - 3 PG - 31 SN - 0036-8709 DO - 10.3390/scipharm87030020 UR - https://m2.mtmt.hu/api/publication/30791312 ID - 30791312 LA - English DB - MTMT ER - TY - JOUR AU - Liu, Jian AU - Wang, Qilong AU - Adu-Frimpong, Michael AU - Wei, Qiuyu AU - Xie, Yujiao AU - Zhang, Kangyi AU - Wei, Chunmei AU - Weng, Wen AU - Ji, Hao AU - Toreniyazov, Elmurat AU - Xu, Ximing AU - Yu, Jiangnan TI - Preparation, in vitro and in vivo evaluation of isoliquiritigenin-loaded TPGS modified proliposomes JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 563 PY - 2019 SP - 53 EP - 62 PG - 10 SN - 0378-5173 DO - 10.1016/j.ijpharm.2019.03.034 UR - https://m2.mtmt.hu/api/publication/31048312 ID - 31048312 N1 - Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Drug Delivery & Tissue Regeneration and Jiangsu Provincial, Jiangsu University, Zhenjiang, 212013, China Research Center for Medicinal Function Development of New Food Resources, Zhenjiang, 212001, China Jiangsu Tian Sheng Pharmaceutical Co., Ltd., No. 10 Baohua Development Zone, Jurong, Zhenjiang, Jiangsu, China Ashkent State Agricultural University (Nukus Branch), Avdanberdi str., Nukus, Karakalpakstan 742009, Uzbekistan Cited By :9 Export Date: 20 February 2021 CODEN: IJPHD Correspondence Address: Xu, X.; Jiangsu University, No. 301, Xuefu Road, Jingkou District, China; email: xmxu@ujs.edu.cn AB - Isoliquiritigenin (ISL) has a great variety of pharmacological effects especially liver cancer therapy, but its poor solubility, bioavailability and liver targeting have limited its clinical use. In order to solve the aforementioned shortcomings, the TPGS-modified proliposomes loaded with ISL (ISL-TPGS-PLP) was prepared in this study. ISL-TPGS- PLP was fabricated via thin-film dispersion method and was characterized by the appearance, particle size, zeta potential and morphology. HPLC was used to evaluate entrapment efficiency (EE), in vitro release and stability of ISL-TPGS-PLP single or combined while appropriate physicochemical parameters were measured with DLS. Meanwhile, the pharmacokinetics and tissue distribution were also studied after oral administration. The results demonstrated that ISL-TPGS-PLP had a mean size of 23.8 +/- 0.9 nm, high EE of 97.33 +/- 0.40%. More importantly, nearly 90% ISL was released from ISL-TPGS-PLP within 24 h while only 50% was released from ISL suspension. In the pharmacokinetics study, the area under the curve (AUC(0-24h)) of ISL-TPGS-PLP was 1.53 times higher than that of ISL suspension. The Tissue distribution study showed that the ISL released from ISL-TPGS-PLP was higher in the liver than the free ISL suspension. Altogether, ISL-TPGS-PLP could ameliorate the ISL solubility, bioavailability and liver targeting ability, suggesting that ISL-TPGS-PLP could serve as a promising nanocarrier for liver cancer therapy. LA - English DB - MTMT ER - TY - JOUR AU - Zhan, Shiping AU - Wang, Jingchang AU - Wang, Weijing AU - Cui, Liyun AU - Zhao, Qicheng TI - Preparation and in vitro release kinetics of nitrendipine-loaded PLLA-PEG-PLLA microparticles by supercritical solution impregnation process JF - RSC ADVANCES J2 - RSC ADV VL - 9 PY - 2019 IS - 28 SP - 16167 EP - 16175 PG - 9 SN - 2046-2069 DO - 10.1039/c9ra01068h UR - https://m2.mtmt.hu/api/publication/31048314 ID - 31048314 N1 - College of Environmental and Chemical Engineering, Dalian University, Dalian, China Chemical and Environmental Protection Engineering Technology Research Center of Liaoning Province, Dalian, China Cited By :7 Export Date: 20 February 2021 CODEN: RSCAC Correspondence Address: Zhan, S.; College of Environmental and Chemical Engineering, China; email: zhanshiping@dlu.edu.cn AB - In this work, drug-loaded polymer microparticles were prepared by a supercritical solution impregnation (SSI) process with nitrendipine as the model drug and PLLA-PEG-PLLA as the drug carrier. The morphology, size, distribution and functional groups of the drug-loaded microparticles were characterized by scanning electron microscopy (SEM), laser particle size analyzer and fourier transform infrared analysis (FTIR). The effects of pressure, temperature and cosolvent concentration on the drug loading and release property of the microparticles prepared with and without cosolvent were investigated. The in vitro drug release kinetics of drug-loaded microparticles was studied with five models. The results indicated that the morphology of the drug-loaded polymer microparticles was not influenced by the SSI process. And the addition of ethanol cosolvent could significantly improve the drug loading of the microparticles. The most satisfied drug loading and the release properties of the microparticles were achieved under 55 degrees C, 13 MPa and cosolvent ethanol concentration of 3%. The drug could be released for more than 140 h. The analysis of the drug release kinetics showed that the experimental data fitted with Ritger-Peppas model were optimal. According to the release exponent value, the in vitro release process of the nitrendipine-loaded microparticles was controlled by Fickian diffusion, which can provides a theoretical basis for drug release of this type of experiment. LA - English DB - MTMT ER - TY - JOUR AU - Chen, S. AU - Luo, Z. AU - Wu, L. AU - Xie, C. AU - Xiao, X. TI - Amino-Modified Polylactic Acid Nanofibre Microspheres as Drug Sustained Release Carriers for Alendronate JF - POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING J2 - POLYM-PLAST TECHNOL VL - 57 PY - 2018 IS - 18 SP - 1873 EP - 1881 PG - 9 SN - 0360-2559 DO - 10.1080/03602559.2018.1447122 UR - https://m2.mtmt.hu/api/publication/31883499 ID - 31883499 N1 - Cited By :5 Export Date: 20 February 2021 Correspondence Address: Xiao, X.; Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, China; email: xfxiao@fjnu.edu.cn LA - English DB - MTMT ER - TY - JOUR AU - Luan, J. AU - Zhang, Z. AU - Shen, W. AU - Chen, Y. AU - Yang, X. AU - Chen, X. AU - Yu, L. AU - Sun, J. AU - Ding, J. TI - Thermogel Loaded with Low-Dose Paclitaxel as a Facile Coating to Alleviate Periprosthetic Fibrous Capsule Formation JF - ACS APPLIED MATERIALS & INTERFACES J2 - ACS APPL MATER INTER VL - 10 PY - 2018 IS - 36 SP - 30235 EP - 30246 PG - 12 SN - 1944-8244 DO - 10.1021/acsami.8b13548 UR - https://m2.mtmt.hu/api/publication/31883500 ID - 31883500 N1 - State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200438, China Department of Breast Surgery, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China Cited By :18 Export Date: 20 February 2021 Correspondence Address: Yu, L.; State Key Laboratory of Molecular Engineering of Polymers, China; email: yu_lin@fudan.edu.cn LA - English DB - MTMT ER - TY - JOUR AU - Wang, J. AU - Cooper, R.C. AU - He, H. AU - Li, B. AU - Yang, H. TI - Polyamidoamine Dendrimer Microgels: Hierarchical Arrangement of Dendrimers into Micrometer Domains with Expanded Structural Features for Programmable Drug Delivery and Release JF - MACROMOLECULES J2 - MACROMOLECULES VL - 51 PY - 2018 IS - 15 SP - 6111 EP - 6118 PG - 8 SN - 0024-9297 DO - 10.1021/acs.macromol.8b01006 UR - https://m2.mtmt.hu/api/publication/31883501 ID - 31883501 N1 - Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23219, United States Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, United States Department of Pharmaceutics, United States Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, United States Cited By :13 Export Date: 20 February 2021 CODEN: MAMOB Correspondence Address: Yang, H.; Department of Chemical and Life Science Engineering, United States; email: hyang2@vcu.edu LA - English DB - MTMT ER - TY - JOUR AU - Yan, S. AU - Li, X. AU - Jian, Y. AU - Wu, N. AU - Teng, C. AU - Zhu, Y. AU - Yin, J. TI - Preparation and Characterization of Poly(L-glutamic acid)/Chitosan Nanogels JF - GAOFENZI CAILIAO KEXUE YU GONGCHENG/POLYMERIC MATERIALS SCIENCE AND ENGINEERING J2 - POLYMER MATER SCIE ENG (CHINA) VL - 34 PY - 2018 IS - 2 SP - 168 EP - 172 and 179 SN - 1000-7555 DO - 10.16865/j.cnki.1000-7555.2018.02.028 UR - https://m2.mtmt.hu/api/publication/31883502 ID - 31883502 N1 - Export Date: 20 February 2021 CODEN: GCKGE Correspondence Address: Yan, S.; Department of Polymer Materials, China; email: yansf@staff.shu.edu.cn LA - Chinese DB - MTMT ER - TY - JOUR AU - Berardi, Alberto AU - Bisharat, Lorina AU - Cespi, Marco AU - Basheti, Iman A AU - Bonacucina, Giulia AU - Pavoni, Lucia AU - AlKhatib, Hatim S TI - Controlled release properties of zein powder filled into hard gelatin capsules JF - POWDER TECHNOLOGY J2 - POWDER TECHNOL VL - 320 PY - 2017 SP - 703 EP - 713 PG - 11 SN - 0032-5910 DO - 10.1016/j.powtec.2017.07.093 UR - https://m2.mtmt.hu/api/publication/26939272 ID - 26939272 N1 - Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University, Amman, 11931, Jordan Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, The University of Jordan, Amman, 11942, Jordan School of Pharmacy, University of Camerino, Camerino, MC 62032, Italy Department of Clinical Pharmacy, Faculty of Pharmacy, Applied Science Private University, Amman, 11931, Jordan Cited By :13 Export Date: 20 February 2021 CODEN: POTEB Correspondence Address: Berardi, A.; Department of Pharmaceutical Sciences and Pharmaceutics, Jordan; email: a_berardi@asu.edu.jo LA - English DB - MTMT ER - TY - JOUR AU - Guan, Jibin AU - Sun, Jin AU - Sun, Feilong AU - Lou, Bo AU - Zhang, Dong AU - Mashayekhi, Vida AU - Sadeghi, Negar AU - Storm, Gert AU - Mastrobattista, Enrico AU - He, Zhonggui TI - Hypoxia-induced tumor cell resistance is overcome by synergistic GAPDH-siRNA and chemotherapy co-delivered by long-circulating and cationic-interior liposomes JF - NANOSCALE J2 - NANOSCALE VL - 9 PY - 2017 IS - 26 SP - 9190 EP - 9201 PG - 12 SN - 2040-3364 DO - 10.1039/c7nr02663c UR - https://m2.mtmt.hu/api/publication/26939274 ID - 26939274 N1 - Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht3584CG, Netherlands Cited By :18 Export Date: 20 February 2021 Correspondence Address: Mastrobattista, E.; Department of Pharmaceutics, Netherlands; email: E.Mastrobattista@uu.nl LA - English DB - MTMT ER - TY - JOUR AU - Ji, Jun AU - He, Xin AU - Yang, Xiao-Lin AU - Du, Wen-Juan AU - Cui, Cheng-Long AU - Wang, Ling AU - Wang, Xue AU - Zhang, Chun-Feng AU - Guo, Chang-Run TI - The In vitro/vivo Evaluation of Prepared Gastric Floating Tablets of Berberine Hydrochloride JF - AAPS PHARMSCITECH J2 - AAPS PHARMSCITECH VL - 18 PY - 2017 IS - 6 SP - 2149 EP - 2156 PG - 8 SN - 1530-9932 DO - 10.1208/s12249-016-0696-7 UR - https://m2.mtmt.hu/api/publication/26939273 ID - 26939273 N1 - State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Lane, Nanjing, Jiangsu 210009, China School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210000, China Cited By :2 Export Date: 20 February 2021 Correspondence Address: Zhang, C.-F.; State Key Laboratory of Natural Medicines, 24 Tongjia Lane, China; email: zhangchunfeng67@163.com LA - English DB - MTMT ER - TY - JOUR AU - Alfonso, Samuel AU - Gonzalez, Sorenlis AU - Higuera-Padilla, Angel R AU - Vidal, Alba AU - Fernandez, Mercedes AU - Taylor, Peter AU - Urdanibia, Izaskun AU - Reiber, Andreas AU - Otero, Yomaira AU - Castro, William TI - A new complex of copper-phosphole. Synthesis, characterization and evaluation of biological activity JF - INORGANICA CHIMICA ACTA J2 - INORG CHIM ACTA VL - 453 PY - 2016 SP - 538 EP - 546 PG - 9 SN - 0020-1693 DO - 10.1016/j.ica.2016.09.012 UR - https://m2.mtmt.hu/api/publication/26406554 ID - 26406554 N1 - Universidad de los Andes, Facultad de Ciencias, Departamento de QuímicaMérida, Venezuela Centro de Química, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, 1020-A, Venezuela Medicina Experimental, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, 1020-A, Venezuela Universidad de los Andes, Facultad de Ciencias, Departamento de Química, Bogotá, Colombia Cited By :6 Export Date: 20 February 2021 CODEN: ICHAA Correspondence Address: Otero, Y.; Centro de Química, Venezuela; email: yomaira@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Wang, Miaomiao AU - Wang, Yuanwen AU - Omari-Siaw, Emmanuel AU - Wang, Shengli AU - Zhu, Yuan AU - Xu, Ximing TI - Reduced Burst Release and Enhanced Oral Bioavailability in Shikimic Acid-Loaded Polylactic Acid Submicron Particles by Coaxial Electrospray JF - JOURNAL OF PHARMACEUTICAL SCIENCES J2 - J PHARM SCI VL - 105 PY - 2016 IS - 8 SP - 2427 EP - 2436 PG - 10 SN - 0022-3549 DO - 10.1016/j.xphs.2016.05.032 UR - https://m2.mtmt.hu/api/publication/26344962 ID - 26344962 N1 - Cited By :9 Export Date: 20 February 2021 CODEN: JPMSA Correspondence Address: Zhu, Y.; Department of Pharmaceutics, China; email: zhuyuanemail@126.com LA - English DB - MTMT ER - TY - JOUR AU - Zhang, Ya AU - Huang, Zhimin AU - Omari-Siaw, E AU - Lu, Shuang AU - Zhu, Yuan AU - Jiang, Dongmei AU - Wang, Miaomiao AU - Yu, Jiangnan AU - Xu, Ximing AU - Zhang, Weiming TI - Preparation and In Vitro-In Vivo Evaluation of Sustained-Release Matrix Pellets of Capsaicin to Enhance the Oral Bioavailability JF - AAPS PHARMSCITECH J2 - AAPS PHARMSCITECH VL - 17 PY - 2016 IS - 2 SP - 339 EP - 349 PG - 11 SN - 1530-9932 DO - 10.1208/s12249-015-0352-7 UR - https://m2.mtmt.hu/api/publication/25716657 ID - 25716657 N1 - Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, 212013, China Nanjing Institute for Comprehensive Utilization of Wild Plants, Nanjing, 210042, China Cited By :14 Export Date: 20 February 2021 Correspondence Address: Xu, X.; Department of Pharmaceutics, China; email: xmxu@ujs.edu.cn LA - English DB - MTMT ER - TY - JOUR AU - Fatmi, Sofiane AU - Bournine, Lamine AU - Iguer-Ouada, Mokrane AU - Lahiani-Skiba, Malika AU - Bouchal, Fatiha AU - Skiba, Mohamed TI - AMORPHOUS SOLID DISPERSION STUDIES OF CAMPTOTHECIN-CYCLODEXTRIN INCLUSION COMPLEXES IN PEG 6000 JF - ACTA POLONIAE PHARMACEUTICA: DRUG RESEARCH J2 - ACTA POL PHARM VL - 72 PY - 2015 IS - 1 SP - 179 EP - 192 PG - 14 SN - 0001-6837 UR - https://m2.mtmt.hu/api/publication/25716658 ID - 25716658 N1 - Technology Pharmaceutical and Biopharmaceutics Laboratory, UFR Medicine and Pharmacy, Rouen University, 22 Blvd. Gambetta, Rouen, 76183, France Technology Pharmaceutical Laboratory, Department of Engineering Processes, United States Marine Ecosystems and Aquaculture Laboratory, Faculty of Natural Sciences and Life, Abderrahmane-Mira University, Targua Ouzemmour road, Bejaia, 06000, Algeria Plant Biotechnology and Ethnobotany Laboratory, Faculty of Natural Sciences and Life, Abderrahmane-Mira University, Targua Ouzemmour road, Bejaia, 06000, Algeria Cited By :6 Export Date: 20 February 2021 CODEN: APPHA LA - English DB - MTMT ER - TY - JOUR AU - Liu, Xiaohong AU - Wang, Shang AU - Chai, Liqing AU - Zhang, Dong AU - Sun, Yinghua AU - Xu, Lu AU - Sun, Jin TI - two-step strategy to design high bioavailable controlled-release nimodipine tablets: The push-pull osmotic pump in combination with the micronization/solid dispersion techniques JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 461 PY - 2014 IS - 1-2 SP - 529 EP - 539 PG - 11 SN - 0378-5173 DO - 10.1016/j.ijpharm.2013.12.023 UR - https://m2.mtmt.hu/api/publication/25716660 ID - 25716660 N1 - Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China Shanxi Provincial People's Hospital, No. 29, Shuangta Street, Taiyuan, China Department of Physical Chemistry, School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China Cited By :24 Export Date: 20 February 2021 CODEN: IJPHD Correspondence Address: Sun, J.; Department of Biopharmaceutics, No. 103, Wenhua Road, Shenyang 110016, China; email: sunjin66@21cn.com LA - English DB - MTMT ER - TY - JOUR AU - Sun, L AU - Zhang, W AU - Liu, X AU - Sun, J TI - Preparation and evaluation of sustained-release azithromycin tablets invitro and invivo JF - ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - A J PHARM SCI VL - 9 PY - 2014 IS - 3 SP - 155 EP - 161 PG - 7 SN - 1818-0876 DO - 10.1016/j.ajps.2014.03.003 UR - https://m2.mtmt.hu/api/publication/26513063 ID - 26513063 N1 - Department of Pharmaceutics, School of Pharmacy, China Medical University, No. 92 Beier Road, Heping District, Shenyang, Liaoning, 110001, China Changzhou Pharmaceutical Factory, No. 518 Laodong East Road, Changzhou, Jiangsu, 213018, China Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China Cited By :5 Export Date: 20 February 2021 Correspondence Address: Sun, J.; Shenyang Pharmaceutical University, No. 103, Wenhua Road, China LA - English DB - MTMT ER - TY - JOUR AU - Yang, Meiyan AU - Xie, Si AU - Li, Qiu AU - Wang, Yuli AU - Chang, Xinyi AU - Shan, Li AU - Sun, Lei AU - Huang, Xiaoli AU - Gao, Chunsheng TI - Effects of polyvinylpyrrolidone both as a binder and pore-former on the release of sparingly water-soluble topiramate from ethylcellulose coated pellets JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 465 PY - 2014 IS - 1-2 SP - 187 EP - 196 PG - 10 SN - 0378-5173 DO - 10.1016/i.ijpharm.2014.02.021 UR - https://m2.mtmt.hu/api/publication/25716659 ID - 25716659 LA - English DB - MTMT ER - TY - JOUR AU - Hu, Jin AU - Guo, Hong AU - Wang, Chenggang AU - Wang, Xinglin TI - An in vitro Comparison of Drug Release from Propranolol Hydrochloride Hydrophilic Matrix Tablets with SWELSTAR~(TM) MX-1 or HPMC as Matrix JF - Chinese Journal of Pharmaceuticals J2 - Chinese Journal of Pharmaceuticals VL - 44 PY - 2013 IS - 3 SP - 249 EP - 253 PG - 5 SN - 1001-8255 UR - https://m2.mtmt.hu/api/publication/23218592 ID - 23218592 LA - Chinese DB - MTMT ER - TY - JOUR AU - Ibrahim, MA AU - Fouad, EA AU - El-Badry, M TI - Employing compritol in a mixed matrix for sustaining chlorpheniramine maleate release: Kinetic study JF - DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES J2 - DIG J NANOMATER BIOS VL - 8 PY - 2013 IS - 2 SP - 737 EP - 746 PG - 10 SN - 1842-3582 UR - https://m2.mtmt.hu/api/publication/23219847 ID - 23219847 N1 - Cited By :2 Export Date: 20 February 2021 Correspondence Address: Fouad, E. A.; Department of Pharmaceutics, P.O. Box 2457, Riyadh 11451, Saudi Arabia; email: bahe2004@yahoo.co.uk LA - English DB - MTMT ER - TY - JOUR AU - Yuan, Z-W AU - Zhou, Y-B AU - Guan, S-X AU - Zhang, Y AU - Hu, B AU - He, F-M TI - Preparation of pramipexole dihydrochloride sustained-release pellets and its released behavior in vitro JF - ZHONGGUO XINYAO ZAZHI / CHINESE JOURNAL OF NEW DRUGS J2 - CHINESE J NEW DRUGS VL - 22 PY - 2013 IS - 1 SP - 107 EP - 110 PG - 4 SN - 1003-3734 UR - https://m2.mtmt.hu/api/publication/25886709 ID - 25886709 N1 - Export Date: 20 February 2021 Correspondence Address: Guan, S.-X.; College of Chinese Pharmacy, , Guangzhou 510006, China; email: drguan@163.net LA - Chinese DB - MTMT ER - TY - JOUR AU - Li, C AU - Hu, C AU - Wen, Z AU - Dong, S TI - The in vitro degradation kinetics of polyurethane prodrug materials JF - ADVANCED MATERIALS RESEARCH J2 - ADV MATER RES VL - 399-401 PY - 2012 SP - 1067 EP - 1070 PG - 4 SN - 1022-6680 DO - 10.4028/www.scientific.net/AMR.399-401.1067 UR - https://m2.mtmt.hu/api/publication/22647778 ID - 22647778 N1 - 2011 International Conference on Chemical, Material and Metallurgical Engineering LA - English DB - MTMT ER - TY - JOUR AU - Liu, Y AU - Sun, Y AU - Sun, J AU - Zhao, N AU - Sun, M AU - He, Z TI - Preparation and in vitro/in vivo evaluation of sustained-release venlafaxine hydrochloride pellets JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 426 PY - 2012 IS - 1-2 SP - 21 EP - 28 PG - 8 SN - 0378-5173 DO - 10.1016/j.ijpharm.2011.12.053 UR - https://m2.mtmt.hu/api/publication/22460588 ID - 22460588 N1 - Cited By :24 Export Date: 20 February 2021 CODEN: IJPHD Correspondence Address: Sun, J.; Department of Pharmaceutics, No. 103 Wenhua Road, Shenyang 110016, China; email: sunjin66@21cn.com LA - English DB - MTMT ER - TY - JOUR AU - Selvaraj, S AU - Karthikeyan, J AU - Saravanakumar, N TI - Chitosan loaded microspheres as an ocular delivery system for acyclovir JF - INTERNATIONAL JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES J2 - INT J PHARM PHARM SCI VL - 4 PY - 2012 IS - 1 SP - 125 EP - 132 PG - 8 SN - 2656-0097 UR - https://m2.mtmt.hu/api/publication/22647779 ID - 22647779 N1 - Cited By :13 Export Date: 20 February 2021 Correspondence Address: Selvaraj, S.; Department of Pharmaceutics, , Coimbatore, Tamilnadu, India; email: selvasangari@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Wang, Yan AU - Song, Xiaoling AU - Chen, Yinfang AU - Wang, Jinqian AU - Wang, Yuesheng AU - Zheng, Ying TI - Preparation of gentian total glycosides intragastric floating pellets and their characteristics of in vitro release JF - CHINESE TRADITIONAL AND HERBAL DRUGS J2 - CHINESE TRADITIONAL AND HERBAL DRUGS VL - 43 PY - 2012 IS - 9 SP - 1751 EP - 1755 PG - 5 SN - 0253-2670 UR - https://m2.mtmt.hu/api/publication/23218585 ID - 23218585 N1 - Institute of Chinese Medicine, University of Macau, Macau 999078, Macau Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006, China Export Date: 20 February 2021 Correspondence Address: Zheng, Y.; Institute of Chinese Medicine, , Macau 999078, Macau; email: 157670292@qq.com LA - Chinese DB - MTMT ER - TY - JOUR AU - Yan, S AU - Rao, S AU - Zhu, J AU - Wang, Z AU - Zhang, Y AU - Duan, Y AU - Chen, X AU - Yin, J TI - Nanoporous multilayer poly(L-glutamic acid)/chitosan microcapsules for drug delivery JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 427 PY - 2012 IS - 2 SP - 443 EP - 451 PG - 9 SN - 0378-5173 DO - 10.1016/j.ijpharm.2012.01.025 UR - https://m2.mtmt.hu/api/publication/22460590 ID - 22460590 N1 - Department of Polymer Materials, Shanghai University, 20 ChengZhong Road, Jiading District, Shanghai 201800, China Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China Cited By :29 Export Date: 20 February 2021 CODEN: IJPHD Correspondence Address: Duan, Y.; Cancer Institute, , Shanghai 200032, China; email: yrduan@shsci.org LA - English DB - MTMT ER - TY - JOUR AU - Pásztor, E AU - Makó, Á AU - Csóka, G AU - Fenyvesi, Z AU - Benkő, Rita AU - Prosszer, M AU - Marton, Sylvia AU - Antal, István AU - Klebovich, Imre TI - New formulation of in situ gelling Metolose-based liquid suppository JF - DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY J2 - DRUG DEV IND PHARM VL - 37 PY - 2011 IS - 1 SP - 1 EP - 7 PG - 7 SN - 0363-9045 DO - 10.3109/03639045.2010.489558 UR - https://m2.mtmt.hu/api/publication/1485433 ID - 1485433 N1 - Manufacturers: Boots, United Kingdom Megjegyzés-21537819 Chemicals/CAS: bicarbonate, 144-55-8, 71-52-3; disodium hydrogen phosphate, 7558-79-4; hydroxymethylcellulose, 37353-59-6; piroxicam, 36322-90-4; potassium chloride, 7447-40-7; sodium chloride, 7647-14-5; Anti-Inflammatory Agents, Non-Steroidal; Gels; Methylcellulose, 9004-67-5; Phosphates; Piroxicam, 36322-90-4; Suppositories; sodium phosphate, 7632-05-5 Manufacturers: Boots, United Kingdom Megjegyzés-21322909 Chemicals/CAS: bicarbonate, 144-55-8, 71-52-3; disodium hydrogen phosphate, 7558-79-4; hydroxymethylcellulose, 37353-59-6; piroxicam, 36322-90-4; potassium chloride, 7447-40-7; sodium chloride, 7647-14-5 Manufacturers: Boots, United Kingdom Department of Pharmaceutics, Semmelweis University, Hogyes E. Str. 7, H-1092 Budapest, Hungary ENT Department, Szent Imre Hospital, Budapest, Hungary Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary Second Department of Pathology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Cited By :13 Export Date: 19 February 2021 CODEN: DDIPD Correspondence Address: Pásztor, E.; Department of Pharmaceutics, Hogyes E. Str. 7, H-1092 Budapest, Hungary; email: pasztor.eszter@citromail.hu Department of Pharmaceutics, Semmelweis University, Hogyes E. Str. 7, H-1092 Budapest, Hungary ENT Department, Szent Imre Hospital, Budapest, Hungary Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary Second Department of Pathology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Cited By :13 Export Date: 20 February 2021 CODEN: DDIPD Correspondence Address: Pásztor, E.; Department of Pharmaceutics, Hogyes E. Str. 7, H-1092 Budapest, Hungary; email: pasztor.eszter@citromail.hu AB - Context: An in situ gelling liquid suppository is liquid at room temperature but forms a gel at body temperature. In our work, Metolose® SM-4000 (methylcellulose) is studied that basically shows thermal gelation at 68°C (2, ww). Objective: The objective was to study the potency of different factors (concentration, pH, additives) to change the value of thermal gelation temperature (Tt) for Metolose® to form an in situ gelling liquid suppository. Materials and methods: We studied the effect of Metolose® concentration, pH, and salts (sodium chloride, potassium chloride, sodium hydrogen carbonate, and sodium monohydrogen phosphate) on Tt by viscosimetry. To choose the appropriate compound, in vitro drug release was examined. Rectal safety test was performed on rats in vivo after 12-hour application. Results: Increasing the Metolose® concentrations (0.54, ww), Tt can be decreased, but it also altered the consistency of gel. pH does not affect the Tt. The water-soluble salts allowed reducing the gelation temperature to 37°C. Sodium monohydrogen phosphate in 4.5 concentration was found to be the most appropriate. The impact of examined factors on in vitro drug release of piroxicam from the in situ-formed gel was characterized according to Fickian diffusion. Metolose® and the chosen salt did not cause any morphological damage on the rectal tissues. Discussion: According to our study, Metolose® has the physical and chemical potential to be used as base for liquid suppositories. © 2011 Informa UK, Ltd. LA - English DB - MTMT ER - TY - JOUR AU - Singh, M R AU - Singh, D AU - Swarnlata, S TI - Development and in vitro evaluation of polar lipid based lipospheres for oral delivery of peptide drugs JF - INTERNATIONAL JOURNAL OF DRUG DELIVERY J2 - INT JOU DRUG DELIVERY VL - 3 PY - 2011 IS - 1 SP - 15 EP - 26 PG - 12 SN - 0975-0215 DO - 10.5138/ijdd.2009.0975.0215.01002 UR - https://m2.mtmt.hu/api/publication/21536415 ID - 21536415 N1 - Cited By :10 Export Date: 20 February 2021 Correspondence Address: Singh, M. R.; Institute of Pharmacy, Pt Ravishankar Shukla University, Raipur (C.G.) 492010, India; email: manjursu@rediffmail.com LA - English DB - MTMT ER - TY - JOUR AU - Singh, M R AU - Singh, D AU - Saraf, S TI - Formulation optimization of controlled delivery system for antihypertensive peptide using response surface methodology JF - AMERICAN JOURNAL OF DRUG DISCOVERY AND DEVELOPMENT J2 - AMERICAN JOURNAL OF DRUG DISCOVERY AND DEVELOPMENT VL - 1 PY - 2011 IS - 3 SP - 174 EP - 187 PG - 14 SN - 2150-427X DO - 10.3923/ajdd.2011.174.187 UR - https://m2.mtmt.hu/api/publication/21536414 ID - 21536414 N1 - Chemicals/CAS: enalapril maleate, 76095-16-4; eudragit, 24938-16-7, 51822-44-7, 9065-11-6; polysorbate 80, 8050-83-7, 9005-65-6 Manufacturers: Roehm Pharma, Germany; Alkem Laboratories, India Cited By :16 Export Date: 20 February 2021 Correspondence Address: Singh, M. R.; University Institute of Pharmacy, , Raipur(C.G), India LA - English DB - MTMT ER - TY - JOUR AU - Singh, MR AU - Singh, D AU - Saraf, S TI - Influence of selected formulation variables on the preparation of peptide loaded lipospheres JF - TRENDS IN MEDICAL RESEARCH J2 - TRENDS IN MEDICAL RESEARCH VL - 6 PY - 2011 IS - 2 SP - 101 EP - 115 PG - 15 SN - 1819-3587 DO - 10.3923/tmr.2011.101.115 UR - https://m2.mtmt.hu/api/publication/23708580 ID - 23708580 N1 - Cited By :10 Export Date: 20 February 2021 Correspondence Address: Singh, M. R.; University Institute of Pharmacy, , Raipur, 492010, India LA - English DB - MTMT ER - TY - JOUR AU - Singh, D AU - Singh, M R AU - Saraf, S AU - Dixit, V K AU - Saraf, S TI - Formulation optimization of metronidazole loaded chitosan microspheres for wound management by 3-factor, 3-level box-behnken design JF - MICRO AND NANOSYSTEMS J2 - MICRO NANOSYSTEMS VL - 2 PY - 2010 IS - 2 SP - 70 EP - 77 PG - 8 SN - 1876-4029 DO - 10.2174/1876402911002020070 UR - https://m2.mtmt.hu/api/publication/21322911 ID - 21322911 N1 - University Institute of Pharmacy, Pt.Ravishankar Shukla University, Raipur (C.G.), India Department of Pharmaceutical sciences, Dr. H.S.Gour Vishwavidyalaya, Sagar (M.P.), India Cited By :8 Export Date: 20 February 2021 Correspondence Address: Singh, D.; University Institute of Pharmacy, , Raipur (C.G.), India; email: deependraiop@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Singh, D AU - Singh, M AU - Saraf, S AU - Dixit, V K AU - Saraf, S TI - Optimization and characterization of gentamicin loaded chitosan microspheres for effective wound healing JF - INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH J2 - INDIAN J PHARM EDUC VL - 44 PY - 2010 IS - 2 SP - 171 EP - 182 PG - 12 SN - 0019-5464 UR - https://m2.mtmt.hu/api/publication/21322910 ID - 21322910 N1 - Chemicals/CAS: chitosan, 9012-76-4; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; tripolyphosphate, 14127-68-5, 7758-29-4 Manufacturers: Spectra Chemicals, India University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.)-492010, India Department of Pharmaceutical sciences, Dr. H.S.Gour Vishwvidyalaya, Sagar (M.P.), India Cited By :28 Export Date: 20 February 2021 Correspondence Address: Singh, D.; University Institute of Pharmacy, , Raipur (C.G.)-492010, India; email: deependraiop@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Fuentes, G AU - Peón, E AU - Campos, Y AU - López, N AU - Resende, C X AU - De Almeida, Soares G TI - Application of new statistical approach to study drug release from OCP coating on titanium sheets JF - KEY ENGINEERING MATERIALS J2 - KEY ENG MATER VL - 396-398 PY - 2009 SP - 511 EP - 514 PG - 4 SN - 1013-9826 DO - 10.4028/0-87849-353-0.511 UR - https://m2.mtmt.hu/api/publication/21322913 ID - 21322913 LA - English DB - MTMT ER - TY - JOUR AU - Lewis, G TI - Properties of antibiotic-loaded acrylic bone cements for use in cemented arthroplasties: A state-of-the-art review JF - JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS J2 - J BIOMED MATER RES B VL - 89 PY - 2009 IS - 2 SP - 558 EP - 574 PG - 17 SN - 1552-4973 DO - 10.1002/jbm.b.31220 UR - https://m2.mtmt.hu/api/publication/21322912 ID - 21322912 N1 - Chemicals/CAS: amikacin, 37517-28-5, 39831-55-5; cefazolin, 25953-19-9, 27164-46-1; clindamycin, 18323-44-9; daptomycin, 103060-53-3; flucloxacillin, 1847-24-1, 5250-39-5; fusidic acid, 6990-06-3; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; meropenem, 96036-03-2; oxacillin, 1173-88-2, 66-79-5, 7240-38-2; palacos, 9011-14-7, 9011-87-4; tobramycin, 32986-56-4; vancomycin, 1404-90-6, 1404-93-9; Anti-Bacterial Agents; Polymethyl Methacrylate, 9011-14-7 Tradenames: Cemex; Endurance; Palacos, Schering Plough; SmartSet Manufacturers: Schering Plough Cited By :77 Export Date: 20 February 2021 CODEN: JBMRG Correspondence Address: Lewis, G.; Department of Mechanical Engineering, , Memphis, TN 38152, United States; email: glewis@memphis.edu LA - English DB - MTMT ER - TY - JOUR AU - Li, H AU - Gao, H AU - Gu, Y -Q TI - Preparation and in vitro evaluation of bovine serum albumin-loaded poly (L-lactic acid) fibers JF - ZHONGGUO YAOKE DAXUE XUEBAO / JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY J2 - ZHONGGUO YAOKE DAXUE XUEBAO / JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY VL - 39 PY - 2008 IS - 1 SP - 23 EP - 27 PG - 5 SN - 1000-5048 UR - https://m2.mtmt.hu/api/publication/21322914 ID - 21322914 N1 - Chemicals/CAS: poly(n isopropylacrylamide), 25189-55-3; polylactic acid, 26100-51-6; water, 7732-18-5 Export Date: 20 February 2021 CODEN: ZHYXE Correspondence Address: Gu, Y.-Q.; School of Life Science and Technology, , Nanjing 210009, China; email: guyueqing@hotmail.com LA - Chinese DB - MTMT ER - TY - JOUR AU - Patel, N M AU - Soniwala, M M TI - Influence of release enhancers on release of venlafaxine hydrochloride from glyceryl behenate matrix tablet JF - Indian Drugs J2 - Indian Drugs VL - 45 PY - 2008 IS - 2 SP - 98 EP - 104 PG - 7 SN - 0019-462X UR - https://m2.mtmt.hu/api/publication/21322915 ID - 21322915 N1 - Chemicals/CAS: glycerol behenate, 18641-57-1; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; microcrystalline cellulose, 39394-43-9, 51395-75-6; venlafaxine, 93413-69-5 Cited By :8 Export Date: 20 February 2021 CODEN: INDRB Correspondence Address: Patel, N. M.; Shri B. M. Shah College of Pharmaceutical Education and Research, Modasa-393315, Gujarat, India; email: nmp_pharmacist@rediffmail.com LA - English DB - MTMT ER - TY - JOUR AU - Rawat, M AU - Singh, D AU - Saraf, S AU - Saraf, S TI - Development and in vitro evaluation of alginate gel-encapsulated, chitosan-coated ceramic nanocores for oral delivery of enzyme JF - DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY J2 - DRUG DEV IND PHARM VL - 34 PY - 2008 IS - 2 SP - 181 EP - 188 PG - 8 SN - 0363-9045 DO - 10.1080/03639040701539479 UR - https://m2.mtmt.hu/api/publication/21322917 ID - 21322917 N1 - Chemicals/CAS: alginic acid, 28961-37-7, 29894-36-8, 9005-32-7, 9005-38-3; calcium phosphate, 10103-46-5, 13767-12-9, 14358-97-5, 7758-87-4; chitosan, 9012-76-4; serratiopeptidase, 37312-62-2, 95077-02-4; Alginates; alginic acid, 9005-32-7; calcium phosphate, dihydrate, 15221-07-5; Calcium Phosphates; Chitosan, 9012-76-4; Drug Carriers; Enzymes; Gels; Glucuronic Acid, 576-37-4; Hexuronic Acids; Peptide Hydrolases, EC 3.4.-; serratiopeptidase, EC 3.4.- Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), India Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), 492010, India Cited By :42 Export Date: 20 February 2021 CODEN: DDIPD Correspondence Address: Saraf, S.; Institute of Pharmacy, , Raipur (C.G.), 492010, India; email: swarnlata_saraf@rediffmail.com LA - English DB - MTMT ER - TY - JOUR AU - Singh, D AU - Saraf, S AU - Dixit, V K AU - Saraf, S TI - Formulation optimization of gentamicin loaded Eudragit RS100 microspheres using factorial design study JF - BIOLOGICAL & PHARMACEUTICAL BULLETIN J2 - BIOL PHARM BULL VL - 31 PY - 2008 IS - 4 SP - 662 EP - 667 PG - 6 SN - 0918-6158 DO - 10.1248/bpb.31.662 UR - https://m2.mtmt.hu/api/publication/21322916 ID - 21322916 N1 - Chemicals/CAS: eudragit rs, 33434-24-1; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; glycerol, 56-81-5; sodium chloride, 7647-14-5; Acrylic Resins; Anti-Bacterial Agents; Culture Media; Delayed-Action Preparations; Eudragit RS, 33434-24-1; Excipients; Gentamicins; Glycerol, 56-81-5; Sodium Chloride, 7647-14-5 Manufacturers: Roehm Pharma, Germany; RS Spectra, India Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, C.G.-492010, India Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar (M.P.), India Cited By :21 Export Date: 20 February 2021 CODEN: BPBLE Correspondence Address: Saraf, S.; Institute of Pharmacy, , Raipur, C.G.-492010, India; email: shailendrasaraf@rediffmail.com LA - English DB - MTMT ER - TY - JOUR AU - Szepes, A AU - Makai, Z AU - Blumer, C AU - Mader, K AU - Kasa, P AU - Révész, Piroska TI - Characterization and drug delivery behaviour of starch-based hydrogels prepared via isostatic ultrahigh pressure JF - CARBOHYDRATE POLYMERS J2 - CARBOHYD POLYM VL - 72 PY - 2008 IS - 4 SP - 571 EP - 578 PG - 8 SN - 0144-8617 DO - 10.1016/j.carbpol.2007.09.028 UR - https://m2.mtmt.hu/api/publication/2187212 ID - 2187212 AB - The purpose of our study was to investigate the applicability of isostatic ultra high pressure (IUHP) for the aim of drug formulation. Aqueous suspensions of potato and maize starches containing theophylline as a model drug were subjected to IUHP. The changes in the structure and morphology of potato and maize starches were investigated. The release profile of theophylline from the pressurized samples was also studied. The aqueous suspensions subjected to WHIP turned into highly viscous gels. The crystalline structure of maize starch was changed, while PS pressurized in aqueous medium retained its original X-ray pattern. The sample containing potato starch as a gel-forming polymer exhibited faster drug dissolution compared to an aqueous theophylline suspension used as a reference, while the pressurization of maize starch resulted in a get exhibiting sustained drug release. The results of the dissolution study can be explained with the changes in structure and morphology of the starches caused by IUHP processing and with the different pressure sensitivities of PS and MS. (c) 2007 Elsevier Ltd. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Lengyel, Miléna AU - Dredán, Judit AU - Shafir, G AU - Klebovich, Imre AU - Antal, István TI - A kioldódási profil jelentősége a stabilitási vizsgálatokban JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 77 PY - 2007 IS - 2 SP - 132 EP - 141 PG - 10 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/1485982 ID - 1485982 N1 - Ellenőrizve teljes szöveg alapján GT AB - The aim of stability testing lies in its possibility of revealing all the effects that may influence the quality, efficacy and safety of a pharmaceutical preparation. The stability of a dosage form means that the release of the active ingredients remains unchanged or within specific limits. The manner of stability testing is regulated by guidelines, which consist of -- besides the regular tests of the active ingredient and the degradation products, the concerning impurities, the water content, the hardness -- the dissolution tests. Most physical changes influence the drug release in vivo, which can -- in vitro -- be followed by dissolution. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Marton, Sylvia AU - Plachy, J TI - Appreciation of scientific researcher life of Prof. Dr. I. Rácz JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 77 PY - 2007 IS - 2 SP - 77 EP - 81 PG - 5 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/2360386 ID - 2360386 N1 - Export Date: 20 February 2021 CODEN: APHGA Correspondence Address: Sylvia, M.; Semmelweis Egyetem Gyógyszerészeti Intézet, Hogyes E. u. 7. - 1092, Budapest LA - Hungarian DB - MTMT ER - TY - THES AU - Szepes, A TI - Application of non-conventional methods in the physico-chemical processing of pharmaceutical biopolymers for the aim of drug formulation PY - 2007 UR - https://m2.mtmt.hu/api/publication/21325715 ID - 21325715 LA - English DB - MTMT ER - TY - JOUR AU - Szepes, A AU - Ulrich, J AU - Farkas, Z AU - Kovács, József AU - Révész, Piroska TI - Freeze-casting technique in the development of solid drug delivery systems JF - CHEMICAL ENGINEERING AND PROCESSING J2 - CHEM ENG PROCESS VL - 46 PY - 2007 IS - 3 SP - 230 EP - 238 PG - 9 SN - 0255-2701 DO - 10.1016/j.cep.2006.06.004 UR - https://m2.mtmt.hu/api/publication/1872173 ID - 1872173 N1 - Megjegyzés-21940563 Z9: 8 University of Szeged, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eötvös u. 6, H-6720 Szeged, Hungary Martin-Luther-University Halle-Wittenberg, FB Ingenieurwissenschaften, Institut für Verfahrenstechnik, D-06099 Halle (Saale), Germany University of Veszprém, Department of Silicate and Materials Engineering, Egyetem u. 10, H-8200 Veszprém, Hungary University of Veszprém, Department of Environmental Engineering and Chemical Technology, P.O. Box 158, H-8200 Veszprém, Hungary Cited By :38 Export Date: 15 October 2020 CODEN: CENPE Correspondence Address: Szabó-Révész, P.; University of Szeged, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eötvös u. 6, H-6720 Szeged, Hungary; email: revesz@pharm.u-szeged.hu Funding details: Deutscher Akademischer Austauschdienst, DAAD Funding details: OTKA T-047166 Funding text 1: This study was supported by the German Academic Exchange Service and the Hungarian Scholarship Committee, and by the Hungarian National Research Foundation (OTKA T-047166), for which the authors express their thanks. AB - The aim of the present study was to develop a fast-dissolving solid dosage form containing theophylline as active ingredient using the freeze-casting technique. The structure, the physical properties and mechanism of drug release from the freeze-casted units were investigated. The examined properties of the samples were compared with those of tablets compressed by an eccentric tableting machine using three different compression pressures. The freeze-casting technique proved to be an appropriate alternative for the development of porous solid drug delivery systems. The mechanical strength of the matrices could be improved by using water-soluble additives, which stabilized the solid bodies during recrystallization upon drying. As compared with the tablets, the freeze-casted units revealed a highly porous nature and a remarkable difference in pore volume size distribution. The results demonstrated that the drug-solvent interaction, enhanced by the structural properties, resulted in a rapid delivery of the theophylline from the solid units into artificial gastric juice. © 2006 Elsevier B.V. All rights reserved. LA - English DB - MTMT ER - TY - THES AU - Nagy, Judit TI - Preparation and evolution of zinc sulphate matrices for individual clinical therapy of Wilson's disease PY - 2005 UR - https://m2.mtmt.hu/api/publication/21322983 ID - 21322983 LA - English DB - MTMT ER - TY - JOUR AU - Pál, Szilárd AU - Mayer, Klára AU - Bodor, A AU - Nagy, Sándor AU - Dévay, Attila TI - Evaluation of dissolution profiles of polyethyleneglycol and hydroxy propyl methyl cellulose based matrix tablets JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - EUR J PHARM SCI VL - 25 PY - 2005 IS - Suppl 1 SP - S167 EP - S168 SN - 0928-0987 UR - https://m2.mtmt.hu/api/publication/1466051 ID - 1466051 LA - English DB - MTMT ER - TY - JOUR AU - Csóka, G AU - Marton, Sylvia AU - Rácz, István TI - Evaluation of drug liberation from "soft-patch" type gel systems by different mathematical models. Hatóanyagfelszabadulás értékelése különbözo matematikai módszerekkel új "soft-patch" típusú gélrendszerekbol TS - Hatóanyagfelszabadulás értékelése különbözo matematikai módszerekkel új "soft-patch" típusú gélrendszerekbol JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 74 PY - 2004 IS - 2 SP - 102 EP - 106 PG - 5 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/1487740 ID - 1487740 N1 - Tradenames: adeps solidus 50; peg 4000 Manufacturers: Welding, Germany; Sigma Aldrich Megjegyzés-21322925 Chemicals/CAS: diclofenac, 15307-79-6, 15307-86-5; lard, 61789-99-9; macrogol 4000, 88747-22-2; stearic acid, 57-11-4, 646-29-7 Tradenames: adeps solidus 50; peg 4000 Manufacturers: Welding, Germany; Sigma Aldrich Export Date: 20 February 2021 CODEN: APHGA Correspondence Address: Csóka, G.; Semmelweis Egyetem, Hogyes E. u. 7. - 1092, Budapest, Hungary AB - Authors investigate "soft-patch" type transdermal delivery gel systems with NSAID (diclofenac-Na). The matrix systems containing 1% pharmacon in dissolved (stearate gel) and in suspended form (PEG and lipophilic gel). The in vitro dissolution test was performed according to USP TTS directives. The acidic skin wrap was simulated by buffer solution of pH=5.5, the liberated and dissolved fraction of drug was determined spectrophotometrically. The rate constants were calculated using different mathematical models (first order kinetics, Fick's law, Higuchi equation, modified Nernst equation /Rácz et al./, Hixon relationship). The aim of investigations was to determine the fit of equations to measurement results, namely in which situation is the rate constant independent of time. The comparison was based on RSD and R2 values. The modified Nernst equation (Rácz's relationship) passed the best on data in the case of all three gel systems, the calculated values were constant at any time point. The shape parameter value (a) confirmed the alterations in liberation processes. The less correlation was observed in the case of Hixon-Crowel equation. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Pallagi, Edina AU - Vass, K AU - Hódi, Klára AU - Kása, Péter AU - Falkay, G. AU - Erős, István AU - Révész, Piroska TI - Iron(II) sulfate release from drop-formed lipophilic matrices developed by special hot-melt technology JF - EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS J2 - EUR J PHARM BIOPHARM VL - 57 PY - 2004 IS - 2 SP - 287 EP - 294 PG - 8 SN - 0939-6411 DO - 10.1016/j.ejpb.2003.10.017 UR - https://m2.mtmt.hu/api/publication/1884375 ID - 1884375 N1 - Megjegyzés-21322924 Chemicals/CAS: ferrous sulfate, 10028-21-4, 10124-49-9, 13463-43-9, 7720-78-7, 7782-63-0; propolis, 8012-89-3; tristearin, 555-43-1; Iron, 7439-89-6; Lipids; Sulfates Manufacturers: Merck, Germany; hungapharma, Hungary LA - English DB - MTMT ER - TY - THES AU - Pallagi, E TI - New possibilities for development of iron(II)sulfate containing solid products with sustained drug release PY - 2004 UR - https://m2.mtmt.hu/api/publication/21323029 ID - 21323029 LA - English DB - MTMT ER - TY - JOUR AU - Yang, M AU - Cui, F AU - You, B AU - Wang, L AU - Yue, P AU - Kawashima, Y TI - A novel pH-dependent gradient-release delivery system for nitrendipine: II. Investigations of the factors affecting the release behaviors of the system JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 286 PY - 2004 IS - 1-2 SP - 99 EP - 109 PG - 11 SN - 0378-5173 DO - 10.1016/j.ijpharm.2004.08.007 UR - https://m2.mtmt.hu/api/publication/21322926 ID - 21322926 N1 - Chemicals/CAS: eudragit, 24938-16-7, 51822-44-7, 9065-11-6; hydroxypropylmethylcellulose acetate succinate, 71138-97-1; hydroxypropylmethylcellulose phthalate, 9050-31-1; nitrendipine, 39562-70-4; Excipients; hydroxypropyl methylcellulose phthalate, 9050-31-1; hypromellose, 8063-82-9; Methylcellulose, 9004-67-5; Nitrendipine, 39562-70-4 Tradenames: eudragit e, Roehm Pharma, Germany Manufacturers: Nanjing, China; Roehm Pharma, Germany; Shinetsu, Japan Department of Pharmaceutics, School of Pharmaceutical Science, Shenyang Pharmaceutical Univ., N., China Gifu Pharmaceutical University, 5-6-1 Mitahora-Higashi, Gifu 502, Japan, Japan Cited By :23 Export Date: 20 February 2021 CODEN: IJPHD Correspondence Address: Department of Pharmaceutics, China; email: cuifude@hotmail.com LA - English DB - MTMT ER - TY - JOUR AU - Zatloukat, Z TI - Weibull eqation and dissolution kinetics (Wibullova rovnice a kinetika disoluce) JF - CESKA A SLOVENSKA FARMACIE J2 - CESKA A SLOVENSKA FARMACIE VL - 53 PY - 2004 IS - 6 SP - 332 EP - 335 PG - 4 SN - 1210-7816 UR - https://m2.mtmt.hu/api/publication/20970214 ID - 20970214 N1 - Katedra Farmaceuticke Technologie, Farmaceutické Fakulty, Univerzity Karlovy, Hradec Králové, Czech Republic Heyrovského 1203, 500 05 Hradec Králové, Czech Republic Cited By :1 Export Date: 17 July 2019 CODEN: CSLFE Correspondence Address: Zatloukal, Z.Heyrovského 1203, 500 05 Hradec Králové, Czech Republic; email: zsz@faf.cuni.cz Katedra Farmaceuticke Technologie, Farmaceutické Fakulty, Univerzity Karlovy, Hradec Králové, Czech Republic Heyrovského 1203, 500 05 Hradec Králové, Czech Republic Cited By :1 Export Date: 20 February 2021 CODEN: CSLFE Correspondence Address: Zatloukal, Z.Heyrovského 1203, 500 05 Hradec Králové, Czech Republic; email: zsz@faf.cuni.cz LA - Czech DB - MTMT ER - TY - JOUR AU - Zheng, Y AU - Zhu, J -B TI - Quality evaluation of nimodipine nanoliposomes freeze-dried powder JF - CHINESE PHARMACEUTICAL JOURNAL - CHUNG-KUO YAO HSUEH TSA CHIH J2 - CHIN PHARMACEUT J - CHUNG YAO HSUEH TSA CHIH VL - 39 PY - 2004 IS - 7 SP - 528 EP - 531 PG - 4 SN - 1001-2494 UR - https://m2.mtmt.hu/api/publication/21322923 ID - 21322923 N1 - Chemicals/CAS: nimodipine, 66085-59-4 Export Date: 20 February 2021 CODEN: ZYZAE Correspondence Address: Zhu, J.-B.; Institute of Pharmaceutics, , Nanjing 210009, China; email: zjbbox02@vip.163.com LA - Chinese DB - MTMT ER - TY - JOUR AU - 张彦青, null AU - 解军波, null AU - 陈大为, null TI - 灯盏花素骨架缓释微丸释药机制的研究 JF - CHINESE TRADITIONAL AND HERBAL DRUGS J2 - CHINESE TRADITIONAL AND HERBAL DRUGS VL - 35 PY - 2004 IS - 5 SP - 517 EP - 519 PG - 3 SN - 0253-2670 UR - https://m2.mtmt.hu/api/publication/22647772 ID - 22647772 LA - Chinese DB - MTMT ER - TY - JOUR AU - Bajdik, J AU - Hódi, Klára AU - Regdon, Géza (ifj.) AU - Haasner, T AU - Révész, Piroska AU - Ulrich, J AU - Erős, István TI - Effect of coating on the flow, wetting and dissolution for dimenhydrinate crystals JF - HUNGARIAN JOURNAL OF INDUSTRY AND CHEMISTRY J2 - HUNG J IND CHEM VL - 30 PY - 2002 IS - 2 SP - 143 EP - 148 PG - 6 SN - 0133-0276 UR - https://m2.mtmt.hu/api/publication/1767237 ID - 1767237 N1 - Nincs jelölve levelező szerzőség a közleményen. (SE SZTE admin5) Dept. of Pharmaceutical Technol., University of Szeged, Eötvös Str. 6, H-6720 Szeged, Hungary Institut fur Verfahrenstechnik/TVT, Martin-Luther-Univ. Halle-Wittenberg, FB Ing. Wiss., D-06099 Halle, Germany Export Date: 15 October 2020 CODEN: HJICA Correspondence Address: Bajdik, J.; Dept. of Pharmaceutical Technol., University of Szeged, Eötvös Str. 6, H-6720 Szeged, Hungary AB - Crystals of dimenhydrinate were coated with a gastric-soluble polymer (hydroxypropyl-methylcellulose) in a fluidized bed apparatus in order to increase the poor flowabilty of crystals. The amount of coating polymer can influence the wetting, the dissolution rate of the active ingredient and the sensitivity to heat. There was an increase in particle size due to the coating, but the increase is less than that during conventional granulation. The flow properties was increased by the film coating. The different wetting behaviour of the crystals is explained in terms of the contact angle of distilled water on the surface of tablets. Here different quantities of film forming polymer were examined. The characteristic water uptake reflects the wetting of the crystals. The thermal sensitivity, determined by a differential scanning calorimetry, was improved by the coating. The quantity of the polymer in the film plays an important part in the thermal sensitivity. LA - English DB - MTMT ER - TY - JOUR AU - Bajdik, J AU - Hódi, Klára AU - Regdon, Géza (ifj.) AU - Erős, István TI - Treatment of particles with low-flow properties JF - DRUGS MADE IN GERMANY J2 - DRUGS MADE IN GERMANY VL - 45 PY - 2002 IS - 1 SP - 25 EP - 29 PG - 5 SN - 0012-6683 UR - https://m2.mtmt.hu/api/publication/1767240 ID - 1767240 AB - The main problems which occur during the preparation of solid dosage forms (especially tablets and capsules) are the insufficient flow of the particles, poor compactibility and inadequate stability of the materials. The aim of preformulation, therefore, is to eliminate such problems, if possible. The effects of granulation and coating were examined. Dimenhydrinate was chosen as a model drug with low-flow properties and decomposition at the melting point. The shape of the particles and the flow properties (angle of repose, mass by volume, flow time, the Hausner factor and Carr's index) were determined. Differential scanning calorimetry was used to check the features of the sample on exposure to heat and to measure the melting point. The effect of the coating film on the melting point was observed during melting. LA - English DB - MTMT ER - TY - JOUR AU - Porta, V AU - Yamamichi, É AU - Storpirtis, S TI - In vitro biopharmaceutic evaluation of capsules containing fluconazole. Avaliação biofarmacêutica in vitro de cápsulas de fluconazol TS - Avaliação biofarmacêutica in vitro de cápsulas de fluconazol JF - REVISTA BRASILEIRA DE CIENCIAS FARMACEUTICAS J2 - REVISTA BRASILEIRA DE CIENCIAS FARMACEUTICAS VL - 38 PY - 2002 IS - 3 SP - 333 EP - 343 PG - 11 SN - 1516-9332 UR - https://m2.mtmt.hu/api/publication/21322928 ID - 21322928 N1 - Chemicals/CAS: fluconazole, 86386-73-4 Departamento de Farmácia, Faculdade de Ciencias Farmaceuticas, Universidade de São Paulo, São Paulo, Brazil Depto. de Farmácia FCF - USP, Av. Prof. Lineu Prestes, 580, 05508-900 São Paulo - SP, Brazil Cited By :10 Export Date: 20 February 2021 CODEN: RBCFF Correspondence Address: Porta, V.; Depto. de Farmácia FCF - USP, Av. Prof. Lineu Prestes, 580, 05508-900 São Paulo - SP, Brazil; email: vporta@usp.br LA - Portuguese DB - MTMT ER - TY - JOUR AU - Antal, István TI - A hatóanyag orális felszívódásának előrejelzésére alkalmazott kioldódás vizsgálatok biofarmáciai vonatkozásai JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 71 PY - 2001 IS - 3 SP - 280 EP - 288 PG - 9 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/1488623 ID - 1488623 N1 - Cited By :12 Export Date: 20 February 2021 CODEN: APHGA Correspondence Address: Antal, I.; Gyogyszereszeti Intezet, Hogyes Endre u. 7, 1092 Budapest, Hungary AB - Drug dissolution is a prerequisite to drug absorption and in vivo effectiveness for almost all drugs given in oral solid dosage forms. Drug absorption depends on the dissolution and solubilization of the drug under physiological conditions, and the permeability across the gastrointestinal tract. Because of the critical nature of the first steps, in vitro dissolution may be relevant to the prediction of biological response. Dissolution tests are applied to choose between formulation factors, assess the lot-to-lot quality of a drug product according to the biobatch; and ensure continuing product quality and performance after certain changes (e.g. in the formulation and manufacturing process, site of manufacture, scale-up). The recently developed Biopharmaceutical Classification System (BCS) has several benefits for recognizing how dissolution tests can be designed and which physiological factors have to be taken into consideration for the in vitro evaluation of solid dosage forms. Choice of test conditions (composition, volume and hydrodynamics of dissolution medium) should be based on where the drug is best absorbed in the gastrointestinal tract, and on whether it is administered in fasted or fed state. Duration of test and physiologically representative media can be selected to simulate gastric and intestinal environments according to the permeability profile of the drug, but mimicking in vivo hydrodynamics remains problematic and further research is required. To provide a basis for predicting the likelihood of achieving a successful in vivo-in vitro correlation, this review summarizes the biopharmaceutical considerations of in vivo drug relase in accordance with the BCS. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bajdik, J AU - Hódi, Klára AU - Regdon, Géza (ifj.) AU - Erős, István TI - Treatment of particles with low-flow properties JF - PHARMAZEUTISCHE INDUSTRIE J2 - PHARM IND VL - 63 PY - 2001 IS - 11 SP - 1197 EP - 1202 PG - 6 SN - 0031-711X UR - https://m2.mtmt.hu/api/publication/1766912 ID - 1766912 N1 - Megjegyzés-21322930 Chemicals/CAS: dimenhydrinate, 523-87-5 Cited By :7 Export Date: 15 October 2020 CODEN: PHINA Correspondence Address: Pintye-Hódi, K.; Dept. of Pharmaceutical Technology, University of Szeged, Eötvös str. 6, 6720 Szeged, Hungary Chemicals/CAS: dimenhydrinate, 523-87-5 LA - English DB - MTMT ER - TY - JOUR AU - Torrado, S AU - Frutos, P AU - Frutos, G TI - Gentamicin bone cements: Characterisation and release (in vitro and in vivo assays) JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 217 PY - 2001 IS - 1-2 SP - 57 EP - 69 PG - 13 SN - 0378-5173 DO - 10.1016/S0378-5173(01)00587-7 UR - https://m2.mtmt.hu/api/publication/21322931 ID - 21322931 N1 - Chemicals/CAS: Acrylic Resins; Anti-Bacterial Agents; Bone Cements; CMW cement, 52051-37-3; Gentamicins; Polymethyl Methacrylate, 9011-14-7 Manufacturers: De Puy Department of Pharmaceutical Technology, Faculty of Pharmacy, Complutense University, Av. Complutense s/n, Madrid 28040, Spain Department of Statistics and Operational Research, Faculty of Pharmacy, Complutense University, Av. Complutense s/n, Madrid 28040, Spain Cited By :62 Export Date: 20 February 2021 CODEN: IJPHD Correspondence Address: Torrado, S.; Dept. of Pharmaceutical Technology, Av. Complutense s/n, Madrid 28040, Spain; email: torrado1@eucmax.sim.ucm.es LA - English DB - MTMT ER - TY - JOUR AU - Csóka, G AU - Dredán, Judit AU - Marton, Sylvia AU - Antal, István AU - Rácz, István TI - Evaluation of different mathematical methods describing drug liberation from new, 'soft-patch' type matrix systems JF - PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY J2 - PHARM DEV TECHNOL VL - 4 PY - 1999 IS - 2 SP - 291 EP - 294 PG - 4 SN - 1083-7450 DO - 10.1081/PDT-100101364 UR - https://m2.mtmt.hu/api/publication/1487289 ID - 1487289 N1 - Manufacturers: Huels, Germany; Sigma Aldrich, Germany; Welding, Germany Megjegyzés-21322933 Chemicals/CAS: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac, 15307-86-5; Gels; Stearates Manufacturers: Huels, Germany; Sigma Aldrich, Germany; Welding, Germany Cited By :8 Export Date: 20 February 2021 CODEN: PDTEF Correspondence Address: Racz, I.; Pharmaceutical Institute, Hogyes E. Str. 7, H-1092 Budapest, Hungary LA - English DB - MTMT ER - TY - JOUR AU - Dredán, Judit AU - Zelkó, Romána AU - Antal, István AU - Bihari, E AU - Rácz, István TI - Effect of chemical properties on drug release from hydrophobic matrices JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 160 PY - 1998 IS - 2 SP - 257 EP - 260 PG - 4 SN - 0378-5173 DO - 10.1016/S0378-5173(97)00354-2 UR - https://m2.mtmt.hu/api/publication/1341083 ID - 1341083 N1 - Megjegyzés-21322935 Chemicals/CAS: wax, 83062-05-9 Cited By :13 Export Date: 20 February 2021 CODEN: IJPHD Correspondence Address: Dredan, J.; Pharmaceutical Institute, Hogyes E. 7, H-1092, Budapest, Hungary LA - English DB - MTMT ER - TY - JOUR AU - Dredán, Judit AU - Zelkó, Romána AU - Antal, István AU - Bihari, E AU - Rácz, István TI - Effect of particle size and coating level on the diffuse reflectance of wax matrices JF - JOURNAL OF PHARMACY AND PHARMACOLOGY J2 - J PHARM PHARMACOL VL - 50 PY - 1998 IS - 2 SP - 139 EP - 142 PG - 4 SN - 0022-3573 DO - 10.1111/j.2042-7158.1998.tb06168.x UR - https://m2.mtmt.hu/api/publication/1341088 ID - 1341088 N1 - Chemicals/CAS: Delayed-Action Preparations; Potassium Chloride, 7447-40-7; Powders; Waxes Cited By :10 Export Date: 20 February 2021 CODEN: JPPMA Correspondence Address: Dredan, J.; Pharmaceutical Institute, Hogyes E. Str. 7, H-1092 Budapest, Hungary LA - English DB - MTMT ER - TY - JOUR AU - Dredán, Judit AU - Zelkó, Romána AU - Bihari, E AU - Rácz, István TI - Poli(etilénglikol)-származékok fizikai-kémiai tulajdonságainak hatása viaszmátrixok hatóanyagleadására JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 68 PY - 1998 IS - 4 SP - 210 EP - 213 PG - 4 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/1342848 ID - 1342848 N1 - Export Date: 20 February 2021 CODEN: APHGA Correspondence Address: Dredan, J.; Gyogyszereszeti Intezet, Hogyes Endre. u. 7, 1092 Budapest, Hungary LA - Hungarian DB - MTMT ER -