@article{MTMT:34593186, title = {HA/PLA Composite Nanoparticles for Enhanced Oral Bioavailability of Capsaicin: Fabrication, Characterization and in vitro-in vivo Evaluation}, url = {https://m2.mtmt.hu/api/publication/34593186}, author = {Zhu, Yuan and Wang, Haiqiao and Adu-Frimpong, Michael and Zou, Zhihui and Jin, Zhou and Zhang, Peiyao and Xue, Yuanyuan and Li, Shuang and Xu, Ying and Yu, Jiangnan and Xu, Ximing}, doi = {10.1002/slct.202303080}, journal-iso = {CHEMISTRYSELECT}, journal = {CHEMISTRYSELECT}, volume = {9}, unique-id = {34593186}, issn = {2365-6549}, abstract = {In this paper, hydroxylapatite (HA) nanoparticles were constructed through the ultrasound-assisted dispersion method. Using scanning electron microscopy (SEM), we studied the preparation methods of HA nanoparticles, and spherical HA nanoparticles with a size of about 50 nm were prepared. Besides, we constructed the HA/PLA composite nanoparticles with polylactic acid (PLA) as the material. The effects of different composite proportions on the HA/PLA composite nanoparticles were investigated before Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscope (TEM), and SEM, were applied to preliminary evaluate the effects of the above-mentioned nanoparticles on capsaicin release. Through an in vitro study, we found that the release rate of the drug could be influenced by various release media and different compounding ratios (of HA and PLA). Furthermore, the pharmacokinetics study of capsaicin powder and capsaicin-loaded HA/PLA composite nanoparticles demonstrated marked increased Cmax, prolongation of Tmax to 8 h, increased T1/2 and mean retention time (MRT) by 6.7 and 5.6 times respectively, coupled with 9240.2 % increase in relative bioavailability. Of note, HA/PLA composite nanoparticles showed good biocompatibility and exhibited good long-term controlled release carriers, coupled with the ability to improve the solubility and bioavailability of a lipophilic drug.Spheroid hydroxylapatite (HA) nanoparticles were constructed with the ultrasound-assisted dispersion method, with polylactic acid (PLA) as the material, HA/PLA composite nanoparticles with different composite ratios were fabricated successfully and investigated with Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscope (TEM) and scanning electron microscopy (SEM). Capsaicin was used as a model drug to investigate the release effect of HA/PLA composite nanoparticles. image}, keywords = {CAPSAICIN; characterization; FABRICATION; BIOAVAILABILITY; COMPOSITE NANOPARTICLES}, year = {2024}, eissn = {2365-6549} } @article{MTMT:34252523, title = {A multivariate metal-organic framework based pH-responsive dual-drug delivery system for chemotherapy and chemodynamic therapy}, url = {https://m2.mtmt.hu/api/publication/34252523}, author = {Akbar, Muhammad Usman and Akbar, Arslan and Saddozai, Umair Ali Khan and Khan, Malik Ihsan Ullah and Zaheer, Muhammad and Badar, Muhammad}, doi = {10.1039/d3ma00389b}, journal-iso = {MATER ADV}, journal = {MATERIALS ADVANCES}, volume = {4}, unique-id = {34252523}, abstract = {Combination therapy has emerged as a promising strategy due to its synergistic therapeutic pathways that enhance anticancer efficacy and limit the emergence of drug resistance. In this work, MIL-88B type multivariate (MTV-1) nanocarriers based on a mixed linker (1,4-benzenedicarboxylic acid and biphenyl-4,4 '-dicarboxylic acid) and metals (iron and cobalt) were synthesized. The presence of the distinct linkers modified the pore makeup of MTV-1 and facilitated the co-encapsulation of two anticancer drugs of varying molecular sizes: 5-fluorouracil (5-FU) and curcumin (CUR). The drug loading measurements on MTV-1@5-FU + CUR represented a loading capacity of 15.9 wt% for 5-FU and 9.3 wt% for CUR, respectively. They further exhibited a pH-responsive drug release pattern with higher concentrations of 5-FU and CUR released at pH 5.5 (simulating cancer microenvironment) compared to pH 7.4 (physiological environment). Moreover, we also demonstrated that MTV-1 MOFs, due to the presence of mixed valence metal ions, could exhibit peroxidase-like activity and catalyze H2O2 decomposition to produce OH radicals for chemodynamic therapy. Cell cytotoxicity assays exhibited significant inhibitory effects of MTV-1@5-Fu + CUR against HepG2 cells with an IC50 of 78.7 mu g mL-1. With dual-drug loading, pH-responsive release, and chemodynamic therapy, MTV-1 shows excellent potential for multifunctional anticancer treatment.By combining two different ligands and metals, MOFs can be fine-tuned for effective encapsulation and delivery of two anticancer drugs.}, year = {2023}, eissn = {2633-5409}, pages = {5653-5667} } @article{MTMT:34083976, title = {CAMPTOTHECIN: SOLUBILITY, IN-VITRO DRUG RELEASE, AND EFFECT ON HUMAN RED BLOOD CELLS AND SPERM COLD PRESERVATION}, url = {https://m2.mtmt.hu/api/publication/34083976}, author = {Fatmi, S. and Taouzinet, L. and Skiba, M. and Iguer-Ouada, M.}, doi = {10.54680/fr23210110712}, journal-iso = {CRYOLETTERS}, journal = {CRYOLETTERS}, volume = {44}, unique-id = {34083976}, issn = {0143-2044}, year = {2023}, eissn = {1742-0644}, pages = {89-99} } @article{MTMT:34083975, title = {Metal-phenolic coated rod-like silica nanocarriers with pH responsiveness for pesticide delivery}, url = {https://m2.mtmt.hu/api/publication/34083975}, author = {Hong, T. and Wan, M. and Lv, S. and Peng, L. and Zhao, Y.}, doi = {10.1016/j.colsurfa.2023.130989}, journal-iso = {COLLOID SURFACE A}, journal = {COLLOIDS AND SURFACES A : PHYSICOCHEMICAL AND ENGINEERING ASPECTS}, volume = {662}, unique-id = {34083975}, issn = {0927-7757}, year = {2023}, eissn = {1873-4359} } @article{MTMT:33863372, title = {Self-Healable, Injectable, and Conductive Supramolecular Eutectogel for the Encapsulation and Sustained Release of the Anticancer Drug Curcumin}, url = {https://m2.mtmt.hu/api/publication/33863372}, author = {Parsana, Nildhara and Kumar, Sugam and Aswal, Vinod K. and El Seoud, Omar and Malek, Naved I.}, doi = {10.1021/acsaenm.2c00095}, journal-iso = {ACS APPL ENERGY MATERIALS}, journal = {ACS APPLIED ENERGY MATERIALS}, volume = {1}, unique-id = {33863372}, issn = {2574-0962}, abstract = {The intriguing properties such as high environmental compatibility of supramolecular gels made solely through reversible noncovalent interactions are of recent interest. To offer proof of concept for the new-age sustainable materials, herein we have designed the self-healable, injectable, and ionic conductive supramolecular eutectogel in natural deep eutectic solvent (NADES). The studied eutectogels were prepared by dissolving the pharmaceutically active cetylpyridinium chloride (C16PyCl) and cetylpyridinium bromide (C16PyBr) in the NADES. The NADES was formed by interacting choline chloride (ChCl) with mono-, di-, and trimeric acids, i.e., formic acid (FA), oxalic acid (OA), and citric acid (CA) through hydrogen bonding. The gelation kinetics of the eutectogel was assessed using turbidity measurement as a function of time, whereas the morphology and mechanical properties were assessed using scanning electron microscopy (SEM) and rheology. To further verify the shape and size of the aggregate within the eutectogel, small angle neutron scattering (SANS) was performed. The eutectogel offers excellent self-healing, injectable, and ionic conductive properties as well as excellent antimicrobial properties, and offers high encapsulation efficiency for curcumin. The sustained release characteristics and release kinetics of curcumin was also investigated. Gel phases, in particular, show high colloidal forces, which, along with their environmentally benign nature, make them a great candidate not only for biomedical applications but also for the industries that require high performance with minimal environmental impact.}, keywords = {CURCUMIN; ionic liquids; Cetylpyridinium bromide; cetylpyridinium chloride; Natural deep eutectic solvent; Self-healing gel; eutectogel}, year = {2023}, pages = {380-393} } @article{MTMT:34593187, title = {A sustainable and smart fungicide release platform through cocrystal nanocapsules for improved utilization rate and environmental safety}, url = {https://m2.mtmt.hu/api/publication/34593187}, author = {Qu, Haibin and Wu, Songgu and Gong, Junbo}, doi = {10.1016/j.cej.2023.145284}, journal-iso = {CHEM ENG J}, journal = {CHEMICAL ENGINEERING JOURNAL}, volume = {473}, unique-id = {34593187}, issn = {1385-8947}, abstract = {Pesticides have always been restricted by environmental factors and utilization rate. Smart delivery systems are important to modify pesticides and improve utilization rate, but the economic and environmental risks of the carriers limit their practical applications. Here, responsive release nanocapsules were constructed with metalphenolic networks and pyraclostrobin - thiophanate-methyl (PYR-TM) cocrystal core to modify the poor physicochemical properties and safety of pesticides. PYR-TM was prepared by sustainable mechanochemical method and deposited by metal-phenolic networks in water, producing the PYR-TM@TA-Cu nanocapsules. The crystal structure and DFT calculations proved that TM improved the photostability of PYR by 75.7-fold through competitive energy absorption of photon and molecular conformation modulation. With a loading capacity up to 91.2%, PYR-TM@TA-Cu exhibited pH-responsive release behavior triggered by acidic conditions, which showed that 43.6%, 51.4%, 62.4% and 81.6% of encapsulated PYR were released at pH 7.9, 6.2, 5.3, and 4.0, respectively. Additionally, PYR-TM@TA-Cu exhibited favorable fungicidal activity (EC50 = 0.123 mg/L) in controlling Botrytis cinerea. The greenhouse control efficiency of fungal infection was enhanced from12.0% to 70.7% by PYRTM@TA-Cu after 7 days spraying. The coating of metal-phenolic network improved the washing persistence of the pesticides from 51.26% to 79.88%, the security for zebrafish by 42-fold, and decreased the leaching potential of the pesticides. Meanwhile, PYR-TM@TA-Cu showed no phytotoxicity on the growth of corn and cucumber plants. Overall, this study provides insight into efficient and sustainable agricultural production with the construction of an eco-friendly nanocapsules platform by cocrystal engineering strategy.}, keywords = {TOXICITY; Photostability; pH-responsive release; cocrystal engineering; green preparation}, year = {2023}, eissn = {1873-3212} } @article{MTMT:33863371, title = {Enzyme-Responsive Lignin Nanocarriers for Triggered Delivery of Abamectin to Control Plant Root-Knot Nematodes (Meloidogyne incognita)}, url = {https://m2.mtmt.hu/api/publication/33863371}, author = {Zhao, Ning and Zhu, Li and Liu, Meichen and He, Liangheng and Xu, Hanhong and Jia, Jinliang}, doi = {10.1021/acs.jafc.2c07466}, journal-iso = {J AGR FOOD CHEM}, journal = {JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY}, volume = {71}, unique-id = {33863371}, issn = {0021-8561}, abstract = {Intelligently responsive nanoparticles can improve insecticidal activity against target organisms and reduce the use of pesticides in agriculture. In this study, enzymatic hydrolysis lignin (EHL) nanocarriers with enzyme responsiveness were successfully prepared by electrostatic interaction, and abamectin (Abm)-loaded EHL-based nanoparticles (Abm@L-CL) were investigated. The release behavior of Abm@L-CL nanoparticles showed that Abm was released rapidly in the presence of cellulase and pectinase but slowly under natural conditions. The insecticidal activity of Abm@L-CL treatment (LC50 = 0.68 mu g/mL) against nematodes (Meloidogyne incognita) was significantly more effective than that of original Abm treatment (LC50 = 1.32 mu g/mL). The mortality rate of Abm@L-CL was more than 90% by applying the same dose of Abm after 12 h. The bioactivity of Abm@L-CL against root-knot nematodes was 1.7-fold greater than that of Abm. The result of fluorescence indicated that nanoparticles could enter the intestinal tract through the oral cavity of nematodes and achieve obvious gastric toxicity. Furthermore, the enzyme-controlled lignin-based Abm nanocarriers could penetrate the tomato root near the elongation zone. This study provided intelligent enzyme-responsive nanocarriers for efficient management of soil-borne diseases and pests in green agricultural inputs.}, keywords = {Meloidogyne incognita; Enzymatic hydrolysis lignin; abamectin; enzyme stimulus-responsive}, year = {2023}, eissn = {1520-5118}, pages = {3790-3799} } @article{MTMT:32959458, title = {Dual Delivery of Fluticasone Propionate and Levocetirizine Dihydrochloride for the Management of Atopic Dermatitis Using a Microemulsion-Based Topical Gel}, url = {https://m2.mtmt.hu/api/publication/32959458}, author = {Almawash, Saud and Quadir, Sheikh Shahnawaz and Al Saqr, Ahmed and Sharma, Gajanand and Raza, Kaisar}, doi = {10.1021/acsomega.1c06393}, journal-iso = {ACS OMEGA}, journal = {ACS OMEGA}, volume = {7}, unique-id = {32959458}, issn = {2470-1343}, abstract = {The current study investigates the potential for topical delivery of a fluticasone propionate (FP) and levocetirizine dihydrochloride (CTZ)-loaded microemulsion (ME) for the management of atopic dermatitis. Various microemulsion components were chosen based on their solubility and emulsification capabilities, and the ternary phase diagram was constructed. A total of 12 microemulsion formulations were screened for various attributes like vesicle size, polydispersity index, zeta-potential, percent transmittance, density, and pH. The average globule size and zeta-potential of FP and levocetirizine-containing ME were 52.12 nm and -2.98 zeta-potential, respectively. Transmission electron microscopy confirmed the spherical nature of the globules. The developed system not only controlled the release of both drugs but also enhanced the efficacy of the drugs on a rodent model. Histopathological studies confirmed the safety of the developed system. The present findings provide evidence for a scalable and simpler approach for the management of atopic dermatitis.}, year = {2022}, eissn = {2470-1343}, pages = {7696-7705}, orcid-numbers = {Raza, Kaisar/0000-0001-8159-8005} } @article{MTMT:32959459, title = {In vitro and in vivo evaluation of a novel lidocaine-loaded cubosomal gel for prolonged local anesthesia}, url = {https://m2.mtmt.hu/api/publication/32959459}, author = {Jiang, Junwen and Wu, Huihua and Zou, Zhenmin}, doi = {10.1177/08853282221087346}, journal-iso = {J BIOMATER APPL}, journal = {JOURNAL OF BIOMATERIALS APPLICATIONS}, volume = {37}, unique-id = {32959459}, issn = {0885-3282}, abstract = {Marketed lidocaine dosage forms (such as ointment, gels, and injections) used to manage acute and chronic pain showed a short duration of action (<2 h). In this study, a lidocaine-loaded cubosomal gel was prepared to sustain the release of lidocaine to prolong the local anesthetic effect (high drug retention in the skin). Lidocaine-loaded cubosomal gels were prepared by melt emulsification and sonication using Pluronic F I 27 and DL-alpha-nnonoolein (at different levels). The cubosomal gels were characterized by morphology, size, zeta potential, entrapment efficacy, assay, viscosity, pH, and texture profiles. Ex vivo lidocaine permeation and retention studies were performed using Sprague-Dawley rat skin. Transmission electron microscopy images confirmed the bi-continuous liquid crystalline phase with a honeycomb cubosome structure. The cubosomal particle size (103-227 nm), viscosity (13,524-1 5,627cp), and entrapment efficacy (78.4-94.7%) increase with the level of monoolein. The ex-vivo permeation study showed a biphasic release pattern, with lidocaine cleared from ointment within 4 h (97.9% cumulative release), while cubosomal gels showed sustained release up to 24 h (53.33-98.86% cumulative release). A skin retention study demonstrated that cubosomes can increase (up to 28-fold) the lidocaine content in the skin (4.56 mg) compared to ointment (0.19 mg). A rabbit skin irritation study showed no sign of irritation after the application of cubosomal gel. In the radiant heat tail-flick study, the local anesthetic effect of lidocaine from the cubosomal gel was sustained for up to 16 h with I.43-fold higher efficacy than marketed ointment. In conclusion, the study demonstrated the potential of cubosomal nanoparticle-laden gel to sustain the release of lidocaine for prolonging local anesthetic effects for pain management.}, keywords = {lidocaine; local anesthesia; animal studies; sustained release; Cubosomes; Ex vivo studies}, year = {2022}, eissn = {1530-8022}, pages = {315-323} } @article{MTMT:33109113, title = {Lignin-based non-crosslinked nanocarriers: A promising delivery system of pesticide for development of sustainable agriculture}, url = {https://m2.mtmt.hu/api/publication/33109113}, author = {Liang, W. and Zhang, J. and Wurm, F.R. and Wang, R. and Cheng, J. and Xie, Z. and Li, X. and Zhao, J.}, doi = {10.1016/j.ijbiomac.2022.08.103}, journal-iso = {INT J BIOL MACROMOL}, journal = {INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES}, volume = {220}, unique-id = {33109113}, issn = {0141-8130}, year = {2022}, eissn = {1879-0003}, pages = {472-481} } @article{MTMT:32959457, title = {Preparation and evaluation of bilayer-core osmotic pump tablets contained topiramate}, url = {https://m2.mtmt.hu/api/publication/32959457}, author = {Lin, Wen and Li, Yinke and Shi, Qiongzhi and Liao, Xiangru and Zeng, Yuan and Tian, Wei and Xie, Xiangyang and Liu, Hui}, doi = {10.1371/journal.pone.0264457}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {17}, unique-id = {32959457}, issn = {1932-6203}, abstract = {Topiramate (TPM) was an antiepileptic agent commonly used in clinical. Studies showed that an oral preparation of TPM with extended-release manner could bring some benefits for epileptics. In this paper, controlled release push-pull osmotic pump (PPOP) tablets of sparingly water-soluble TPM were successfully prepared. This bi-layer tablet core mainly consisted of sodium chloride as osmotic promoting agent and polyethylene oxide as suspending and pushing agents. The influences of osmotic agents, pushing agents and the compositions of coating membrane on TPM release profiles were evaluated. An optimal formulation of TPM-PPOP was obtained through single-factor experiments. In vitro release tests showed that the optimum formulation could release TPM at an approximate zero-order rate up to 8 h. Pharmacokinetic behaviors of TPM-PPOP tablets were evaluated and compared with the immediate release capsules after an oral single dose in beagle dogs. Pharmacokinetics results demonstrated that the TPM-PPOP tablet was able to provide a prolonged release of TPM with longer t(max) and mean residence time. Lower fluctuations of drug plasma levels could also be achieved with TPM-PPOP tablets. These results suggested that sparely water-soluble drugs as TPM can be designed to PPOP for efficacy and safety use.}, year = {2022}, eissn = {1932-6203}, orcid-numbers = {Xie, Xiangyang/0000-0001-8260-3988} } @article{MTMT:32959456, title = {MOF-801 as a Nanoporous Water-Based Carrier System for In SituEncapsulation and Sustained Release of 5-FU for Effective Cancer Therapy}, url = {https://m2.mtmt.hu/api/publication/32959456}, author = {Parsaei, Mozhgan and Akhbari, Kamran}, doi = {10.1021/acs.inorgchem.2c00380}, journal-iso = {INORG CHEM}, journal = {INORGANIC CHEMISTRY}, volume = {61}, unique-id = {32959456}, issn = {0020-1669}, abstract = {Nanoporous metal-organic frameworks (MOFs)have been gaining a reputation for their drug delivery applications.In the current work, MOF-801 was successfully prepared by afacile, cost-efficient, and environmentally friendly approachthrough the reaction of ZrCl4and fumaric acid as organic linkersto deliver 5-fluorouracil (5-FU). The prepared nanostructure wasfully characterized by a series of analytical techniques includingFourier transform infrared spectroscopy, powder X-ray diffraction,field-emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, UV-vis spectroscopy,1H NMR spectroscopy,thermogravimetric analysis, high-performance liquid chromatog-raphy, and Brunauer-Emmett-Teller analysis. MOF-801 could beused for the delivery of the anticancer drug 5-FU due to its highsurface area, suitable pore size, and biocompatible ingredients. Based on in vitro loading and release studies, a high 5-FU loadingcapacity and pH-dependent drug release behavior were observed. Moreover, the interactions between the structure of MOFs and 5-FU were investigated through Monte Carlo simulation calculations. An in vitro cytotoxicity test was done, and the results indicatedthat 5-FU@MOF-801 was more potent than 5-FU on SW480 cancerous cells, indicating the highlighted role of this drug deliverysystem. Finally, the kinetics of drug release was investigated.}, year = {2022}, eissn = {1520-510X}, pages = {5912-5925}, orcid-numbers = {Akhbari, Kamran/0000-0002-4574-683X} } @article{MTMT:34083978, title = {Formulation and In Vivo Evaluation of Pharmacokinetics Parameters of Extended Release Matrix Tablet Containing Drug Benidipine Hydrochloride by Using PK Solver Software}, url = {https://m2.mtmt.hu/api/publication/34083978}, author = {Prusty, A. and Gupta, B.K. and Mishra, A.}, doi = {10.52711/0974-360X.2022.00827}, journal-iso = {RES J PHAR TECH}, journal = {RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY}, volume = {15}, unique-id = {34083978}, issn = {0974-3618}, year = {2022}, eissn = {0974-360X}, pages = {4924-4930} } @article{MTMT:32959455, title = {Acetalated dextran microparticles for the smart delivery of pyraclostrobin to control Sclerotinia diseases}, url = {https://m2.mtmt.hu/api/publication/32959455}, author = {Xie, Zhengang and Liang, Wenlong and Xiong, Qiuyu and Zhao, Yanyan and Cheng, Jingli and Li, Xianbin and Zhao, Jinhao}, doi = {10.1016/j.carbpol.2022.119576}, journal-iso = {CARBOHYD POLYM}, journal = {CARBOHYDRATE POLYMERS}, volume = {291}, unique-id = {32959455}, issn = {0144-8617}, abstract = {Dextran has emerged as a promising biopolymer carrier for controlled release formulations of pesticides. In this study, pH-sensitive acetalated dextran microparticles (Pyr@Ac-Dex) are prepared to encapsulate and control the release of pyraclostrobin (Pyr). In vitro fungicidal activity experiments showed that the prepared Pyr@Ac-Dex particles show comparable fungicidal ability against S. sclerotiorum compared to that of Pyr technical. In a 10 -day pot experiment, the control efficacy of the Pyr@Ac-Dex treatment against S. sclerotiorum (77.1%) is signif-icantly higher than that of Pyr emulsifiable concentrate (Pyr EC) treatment (42.4%). Photodegradation experi-ments show that compared to Pyr technical, Pyr@Ac-Dex doubles the half-life of Pyr in water. Acute toxicity experiments show that Pyr@Ac-Dex significantly reduced the acute exposure toxicity of Pyr to zebrafish. This study provides an environmentally friendly, feasible, and sustainable strategy for plant disease management.}, keywords = {controlled release; Sclerotinia sclerotiorum; pH-responsive; pyraclostrobin; acetalated dextran}, year = {2022}, eissn = {1879-1344} } @article{MTMT:32394319, title = {Enhanced Analytic Approach for Describing pH Triggered Fast Drug Release Systems}, url = {https://m2.mtmt.hu/api/publication/32394319}, author = {Elmas, Aykut and Akyuz, Guliz and Bergal, Ayhan and Andac, Muberra and Andac, Omer}, doi = {10.2174/1567201818999210112181853}, journal-iso = {CURR DRUG DELIV}, journal = {CURRENT DRUG DELIVERY}, volume = {18}, unique-id = {32394319}, issn = {1567-2018}, abstract = {Background: pH sensitive dendrimers attached to nanocarriers, as one of the drug release systems, have become quite popular due to their ease of manufacture in experimental conditions and the ability to generate fast drug release in the targeted area. This kind of fast release behavior cannot be represented properly in most of the existing kinetic mathematical models. Besides, these models have either no pH dependence or pH dependence added separately. Therefore, they remained one dimensional. Objective: The aim of this study was to establish the proper analytic equation to describe the fast release of drugs from pH sensitive nanocarrier systems, and to combine it with the pH dependent equation for to establish a two-dimensional model for whole system. Methods: We used four common kinetic models for the comparison and we fitted them to the release data. As a result, only Higuchi and Korsmeyer-Peppas models show acceptable suitable results. None of these models have pH dependence. To get a better description for pH triggered fast release, we observed the behavior of the slope angle of the release curve. Then we proposed a new analytic equation by using relation between the slope angle and time. Result: By adding a pH dependent equation, we assumed the drug release is "on" or "off" above/below specific pH value and we modified a step function to get a desired behavior. Conclusion: Our new analytic model shows good fitting, not only one-dimensional time dependent release, but also two-dimensional pH dependent release, that provides a useful analytic model to represent release profiles of pH sensitive fast drug release systems.}, keywords = {PH; Drug delivery; controlled release; Drug release; Blood Circulation; mathematical modeling}, year = {2021}, eissn = {1875-5704}, pages = {1118-1124}, orcid-numbers = {Elmas, Aykut/0000-0002-7721-4088} } @article{MTMT:32394323, title = {New Formulation and Evaluation of Camptothecin Encapsulated and/or Dispersed Suppository}, url = {https://m2.mtmt.hu/api/publication/32394323}, author = {Fatmi, Sofiane and Taouzinet, Lamia and Lahiani-Skiba, Malika and Skiba, Mohamed and Iguer-Ouada, Mokrane}, doi = {10.2174/1871520620666200903150635}, journal-iso = {ANTI-CANCER AGENT ME}, journal = {ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY}, volume = {21}, unique-id = {32394323}, issn = {1871-5206}, abstract = {Background: Camptothecin is known for its potent anticancer activity. However, its optimal activity is reduced due to its low solubility and stability in biological media.Objective: The aim of the present study is to design and characterize a Camptothecin (CPT) suppository formulation.Methods: Rectal suppositories of camptothecin alone, encapsulated with Cyclodextrin (CD) and in the ternary system (CPT encapsulated with cyclodextrin and dispersed in Polyethylene Glycol (PEG) 6000) were prepared using various hydrophobic and hydrophilic polymeric bases as semi-synthetic glyceride (Suppocire (R) AM Pellets) and Polyethylene Glycols (PEGs) mixtures. Formulations were evaluated by various parameters like weight variation, drug content, hardness and liquefaction time. In vitro release study was performed in USP type I apparatus using phosphate buffer pH 7.2 as dissolution media.Results: Suppositories were within the permissible range of all physical parameters. In vitro drug released from water soluble base (PEG) was greater than that from oil soluble base with ninety percent (90%) of drug dissolution. It was also established that drug release from various formulations was by diffusion mechanism, according to the Higuchi's equation.Conclusion: This new formulation offers a new approach to colorectal cancer treatment by offering an alternative and simple drug administration route.}, keywords = {colorectal cancer; cyclodextrin; kinetic model; suppository; camptothecin; Polyethylene Glycol}, year = {2021}, eissn = {1875-5992}, pages = {1183-1190} } @article{MTMT:32394322, title = {Supramolecular gel formation regulated by water content in organic solvents: self-assembly mechanism and biomedical applications}, url = {https://m2.mtmt.hu/api/publication/32394322}, author = {Liao, Lieqiang and Jia, Xinjian and Lou, Haoxiang and Zhong, Jinlian and Liu, Huijin and Ding, Shunming and Chen, Chao and Hong, Sanguo and Luo, Xuzhong}, doi = {10.1039/d1ra00647a}, journal-iso = {RSC ADV}, journal = {RSC ADVANCES}, volume = {11}, unique-id = {32394322}, issn = {2046-2069}, abstract = {As one of the most important and fruitful methods, supramolecular self-assembly has a significant advantage in designing and fabricating functional soft materials with various nanostructures. In this research, a low-molecular-weight gelator, N,N '-di(pyridin-4-yl)-pyridine-3,5-dicarboxamide (PDA-N4), was synthesized and used to construct self-assembled gels via a solvent-mediated strategy. It was found that PDA-N4 could form supramolecular gels in mixed solvents of water and DMSO (or DMF) at high water fraction (greater than or equal to 50%). By decreasing the water fraction from 50% to 30%, the gel, suspension and solution phases appeared successively, indicating that self-assembled aggregates could be efficiently modulated via water content in organic solvents. Moreover, the as-prepared PDA-N4 supramolecular gels not only displayed solid-like behavior, and pH- and thermo-reversible characteristics, but also showed a solution-gel-crystal transition with the extension of aging time. Further analyses suggested that both the crystal and gel had similar assembled structures. The intermolecular hydrogen bonding between amide groups and the pi-pi stacking interactions between pyridine groups played key roles in gel formation. Additionally, the release behavior of vitamin B12 (VB12) from PDA-N4 gel (H2O/DMSO, v/v = 90/10) was evaluated, and the drug controlled release process was consistent with a first-order release mechanism. The human umbilical venous endothelial cell culture results showed that the PDA-N4 xerogel has good cytocompatibility, which implied that the gels have potential biological application in tissue engineering and controlled drug release.}, year = {2021}, eissn = {2046-2069}, pages = {11519-11528}, orcid-numbers = {Luo, Xuzhong/0000-0002-5719-9407} } @article{MTMT:31883498, title = {QbD-steered development of Biotin-Conjugated Nanostructured Lipid Carriers for Oral Delivery of Chrysin: Role of Surface Modification for Improving Biopharmaceutical Performance}, url = {https://m2.mtmt.hu/api/publication/31883498}, author = {Sharma, T. and Katare, O.P. and Jain, A. and Jain, S. and Chaudhari, D. and Borges, B. and Singh, B.}, doi = {10.1016/j.colsurfb.2020.111429}, journal-iso = {COLLOID SURFACE B}, journal = {COLLOIDS AND SURFACES B: BIOINTERFACES}, volume = {197}, unique-id = {31883498}, issn = {0927-7765}, year = {2021}, eissn = {1873-4367} } @article{MTMT:32394320, title = {Metal-phenolic coated and prochloraz-loaded calcium carbonate carriers with pH responsiveness for environmentally-safe fungicide delivery}, url = {https://m2.mtmt.hu/api/publication/32394320}, author = {Xiao, Douxin and Cheng, Jingli and Liang, Wenlong and Sun, Lianli and Zhao, Jinhao}, doi = {10.1016/j.cej.2021.129274}, journal-iso = {CHEM ENG J}, journal = {CHEMICAL ENGINEERING JOURNAL}, volume = {418}, unique-id = {32394320}, issn = {1385-8947}, abstract = {The study of release mechanisms of pesticides with respect to environmental and biological factors facilitates improvement in pesticide use efficiencies and reduction in environmental risk. In this study, prochloraz (Pro), a highly effective fungicide, was loaded into starch-doped porous calcium carbonate (CaCO3), which was subsequently coated with a metal-phenolic film to prepare a pH-responsive delivery system (PC@TA/Cu). Results demonstrated that CaCO3 had a mean diameter of 1.55 mu m and its loading capacity for Pro was similar to 15.2%. PC@TA/Cu microparticles show good adhesion to rapeseed oil leaves and resisted washout with simulated rainwater. The cumulative release rate of PC@TA/Cu particles at pH = 3 was 1.63 times higher than that in nearneutral pH environment for 48 h. This pH-responsive release characteristic could be associated with the oxalic acid secreted by Sclerotinia sclerotiorum. The control effect against Sclerotinia disease with 100 mu g/mL of Pro content of PC@TA/Cu was 56.8% after 7 d, while that of Pro EW (emulsion in water) was 45.8%. Finally, biosafety tests showed a 4-fold reduction in the acute toxicity of PC@TA/Cu to zebrafish, compared to the that of Pro technical. The carrier (CaCO3@TA/Cu) had no significant effect on the growth of rapeseed oil seedlings. The results showed that the prepared PC@TA/Cu has long-lasting disease control capability and significantly reduced toxicity to non-target organisms, making it valuable for potential applications.}, keywords = {calcium carbonate; Sclerotinia sclerotiorum; prochloraz; pH responsiveness; Metal-phenolic film}, year = {2021}, eissn = {1873-3212} } @article{MTMT:31440104, title = {Chitosan-Ellagic Acid Nanohybrid for Mitigating Rotenone-induced Oxidative Stress}, url = {https://m2.mtmt.hu/api/publication/31440104}, author = {Ahlawat, Jyoti and Neupane, Rabin and Deemer, Eva and Sreenivasan, Sreeprasad T. and Narayan, Mahesh}, doi = {10.1021/acsami.9b21215}, journal-iso = {ACS APPL MATER INTER}, journal = {ACS APPLIED MATERIALS & INTERFACES}, volume = {12}, unique-id = {31440104}, issn = {1944-8244}, abstract = {Antioxidants derived from nature, such as ellagic acid (EA), demonstrated high potency to mitigate neuronal oxidative stress and related pathologies, including Parkinson's disease. However, the application of EA is limited due to its toxicity at moderate doses and poor solubility, cellular permeability, and bioavailability. Here, we introduce a sustainably resourced, green nanoencasement strategy to overcome the limitations of EA and derive synergistic effects to prevent oxidative stress in neuronal cells. Chitosan, with its high biocompatibility, potential antioxidant properties, and flexible surface chemistry, was chosen as the primary component of the nanoencasement in which EA is immobilized. Using a rotenone model to mimic intracellular oxidative stress, we examined the effectiveness of EA and chitosan to limit cell death. Our studies indicate a synergistic effect between EA and chitosan in mitigating rotenone-induced reactive oxygen species death. Our analysis suggests that chitosan encapsulation of EA reduces the inherent cytotoxicity of the polyphenol (a known anticancer molecule). Furthermore, its encapsulation permits its delivery via a rapid burst phase and a relatively slow phase making the nanohybrid suitable for drug release over extended time periods.}, keywords = {rotenone; ellagic acid; Chitosan; nanohybrid; Oxidative stress; Parkinson’ disease; prophylactic effect}, year = {2020}, eissn = {1944-8252}, pages = {18964-18977}, orcid-numbers = {Deemer, Eva/0000-0001-9112-8971} } @article{MTMT:31694856, title = {A novel kinetic model to describe the ultra-fast triggered release of thermosensitive liposomal drug delivery systems}, url = {https://m2.mtmt.hu/api/publication/31694856}, author = {Lu, Tao and ten Hagen, Timo L. M.}, doi = {10.1016/j.jconrel.2020.05.047}, journal-iso = {J CONTROL RELEASE}, journal = {JOURNAL OF CONTROLLED RELEASE}, volume = {324}, unique-id = {31694856}, issn = {0168-3659}, abstract = {Thermosensitive liposomes, as one of the stimuli-responsive drug delivery systems, receive growing attention, due to their ability to generate rapid and massive drug release in the heated area, and marginal release of contents in non-heated parts of the body. This typical triggered release behavior cannot be fitted adequately by most of the current mathematical kinetic models. The aim of this study was to establish the proper kinetic equation to describe the rapid release of drugs from trigger-sensitive drug delivery systems. We summarized all commonly used kinetic models mentioned in the literature and fitted the release data with these models, finding that only the Korsmeyer-Peppas and the Weibull models show acceptable fitting results. To better describe the release from thermosensitive liposomes with a size below 100 nm, we took Laplace pressure as a release-driving force and proposed a new equation that demonstrates improved fitting in liposomes ranging down to a size of 70 nm. Our new kinetic model shows desirable fitting, not only at the optimal temperature but also of releases within the whole release-temperature range, providing a useful kinetic model to describe release profiles of smaller nano-sized stimuli-responsive drug delivery systems.}, keywords = {RELEASE KINETICS; Thermosensitive liposomes; Rapid triggered release; Pressure-driven release}, year = {2020}, eissn = {1873-4995}, pages = {669-678} } @article{MTMT:31440106, title = {Pharmaceutical Formulation and Characterization of Dipeptide Nanotubes for Drug Delivery Applications}, url = {https://m2.mtmt.hu/api/publication/31440106}, author = {Porter, Simon L. and Coulter, Sophie M. and Pentlavalli, Sreekanth and Laverty, Garry}, doi = {10.1002/mabi.202000115}, journal-iso = {MACROMOL BIOSCI}, journal = {MACROMOLECULAR BIOSCIENCE}, volume = {20}, unique-id = {31440106}, issn = {1616-5187}, abstract = {Peptide nanotubes are promising materials for a variety of biomedical applications with ultrashort (<= 7 amino acids) forms providing particular promise for clinical translation. The manufacture of peptide nanotubes has, however, been associated with toxic organic solvents restricting clinical use. The purpose of this work is to formulate dipeptide nanotubes using mild techniques easily translated to industrial upscale and to characterize their physiochemical and biological properties. Phenylalanine-phenylalanine variants can be successfully formulated using distilled water as demonstrated here. Formulations are homogenous in shape (tubular), with apparent size (50-260 nm) and a zeta potential of up to +30 mV. L-(H2N-FF-COOH), and D-enantiomers (H2N-ff-COOH) demonstrate no toxicity against glioblastoma cells and are explored for ability to deliver a model hydrophilic molecule, sodium fluorescein, at pH 5.5 (tumor) and 7.4 (physiological). Peptide nanotubes loaded with >85% sodium fluorescein, demonstrate burst release characteristics, fitting the Weibull model of drug release. This research provides important data contributing to the pharmaceutical formulation of peptide nanotubes as drug delivery platforms for hydrophilic drugs.}, keywords = {PEPTIDE; Nanotubes; Formulation; Drug delivery; nanomaterials}, year = {2020}, eissn = {1616-5195}, orcid-numbers = {Laverty, Garry/0000-0002-1435-2942} } @article{MTMT:30791312, title = {Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery}, url = {https://m2.mtmt.hu/api/publication/30791312}, author = {Lengyel, Miléna and Kállai-Szabó, Nikolett and Antal, Vince and Laki, András József and Antal, István}, doi = {10.3390/scipharm87030020}, journal-iso = {SCI PHARM}, journal = {SCIENTIA PHARMACEUTICA}, volume = {87}, unique-id = {30791312}, issn = {0036-8709}, year = {2019}, eissn = {2218-0532}, orcid-numbers = {Lengyel, Miléna/0000-0001-8865-054X; Kállai-Szabó, Nikolett/0000-0002-8164-3993; Antal, István/0000-0002-5434-201X} } @article{MTMT:31048312, title = {Preparation, in vitro and in vivo evaluation of isoliquiritigenin-loaded TPGS modified proliposomes}, url = {https://m2.mtmt.hu/api/publication/31048312}, author = {Liu, Jian and Wang, Qilong and Adu-Frimpong, Michael and Wei, Qiuyu and Xie, Yujiao and Zhang, Kangyi and Wei, Chunmei and Weng, Wen and Ji, Hao and Toreniyazov, Elmurat and Xu, Ximing and Yu, Jiangnan}, doi = {10.1016/j.ijpharm.2019.03.034}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {563}, unique-id = {31048312}, issn = {0378-5173}, abstract = {Isoliquiritigenin (ISL) has a great variety of pharmacological effects especially liver cancer therapy, but its poor solubility, bioavailability and liver targeting have limited its clinical use. In order to solve the aforementioned shortcomings, the TPGS-modified proliposomes loaded with ISL (ISL-TPGS-PLP) was prepared in this study. ISL-TPGS- PLP was fabricated via thin-film dispersion method and was characterized by the appearance, particle size, zeta potential and morphology. HPLC was used to evaluate entrapment efficiency (EE), in vitro release and stability of ISL-TPGS-PLP single or combined while appropriate physicochemical parameters were measured with DLS. Meanwhile, the pharmacokinetics and tissue distribution were also studied after oral administration. The results demonstrated that ISL-TPGS-PLP had a mean size of 23.8 +/- 0.9 nm, high EE of 97.33 +/- 0.40%. More importantly, nearly 90% ISL was released from ISL-TPGS-PLP within 24 h while only 50% was released from ISL suspension. In the pharmacokinetics study, the area under the curve (AUC(0-24h)) of ISL-TPGS-PLP was 1.53 times higher than that of ISL suspension. The Tissue distribution study showed that the ISL released from ISL-TPGS-PLP was higher in the liver than the free ISL suspension. Altogether, ISL-TPGS-PLP could ameliorate the ISL solubility, bioavailability and liver targeting ability, suggesting that ISL-TPGS-PLP could serve as a promising nanocarrier for liver cancer therapy.}, keywords = {isoliquiritigenin; TPGS; Proliposomes; Targeted drug delivery system; In vitro and in vivo evaluation}, year = {2019}, eissn = {1873-3476}, pages = {53-62}, orcid-numbers = {Wang, Qilong/0000-0003-2186-4249} } @article{MTMT:31048314, title = {Preparation and in vitro release kinetics of nitrendipine-loaded PLLA-PEG-PLLA microparticles by supercritical solution impregnation process}, url = {https://m2.mtmt.hu/api/publication/31048314}, author = {Zhan, Shiping and Wang, Jingchang and Wang, Weijing and Cui, Liyun and Zhao, Qicheng}, doi = {10.1039/c9ra01068h}, journal-iso = {RSC ADV}, journal = {RSC ADVANCES}, volume = {9}, unique-id = {31048314}, issn = {2046-2069}, abstract = {In this work, drug-loaded polymer microparticles were prepared by a supercritical solution impregnation (SSI) process with nitrendipine as the model drug and PLLA-PEG-PLLA as the drug carrier. The morphology, size, distribution and functional groups of the drug-loaded microparticles were characterized by scanning electron microscopy (SEM), laser particle size analyzer and fourier transform infrared analysis (FTIR). The effects of pressure, temperature and cosolvent concentration on the drug loading and release property of the microparticles prepared with and without cosolvent were investigated. The in vitro drug release kinetics of drug-loaded microparticles was studied with five models. The results indicated that the morphology of the drug-loaded polymer microparticles was not influenced by the SSI process. And the addition of ethanol cosolvent could significantly improve the drug loading of the microparticles. The most satisfied drug loading and the release properties of the microparticles were achieved under 55 degrees C, 13 MPa and cosolvent ethanol concentration of 3%. The drug could be released for more than 140 h. The analysis of the drug release kinetics showed that the experimental data fitted with Ritger-Peppas model were optimal. According to the release exponent value, the in vitro release process of the nitrendipine-loaded microparticles was controlled by Fickian diffusion, which can provides a theoretical basis for drug release of this type of experiment.}, year = {2019}, eissn = {2046-2069}, pages = {16167-16175} } @article{MTMT:31883499, title = {Amino-Modified Polylactic Acid Nanofibre Microspheres as Drug Sustained Release Carriers for Alendronate}, url = {https://m2.mtmt.hu/api/publication/31883499}, author = {Chen, S. and Luo, Z. and Wu, L. and Xie, C. and Xiao, X.}, doi = {10.1080/03602559.2018.1447122}, journal-iso = {POLYM-PLAST TECHNOL}, journal = {POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING}, volume = {57}, unique-id = {31883499}, issn = {0360-2559}, year = {2018}, eissn = {1525-6111}, pages = {1873-1881} } @article{MTMT:31883500, title = {Thermogel Loaded with Low-Dose Paclitaxel as a Facile Coating to Alleviate Periprosthetic Fibrous Capsule Formation}, url = {https://m2.mtmt.hu/api/publication/31883500}, author = {Luan, J. and Zhang, Z. and Shen, W. and Chen, Y. and Yang, X. and Chen, X. and Yu, L. and Sun, J. and Ding, J.}, doi = {10.1021/acsami.8b13548}, journal-iso = {ACS APPL MATER INTER}, journal = {ACS APPLIED MATERIALS & INTERFACES}, volume = {10}, unique-id = {31883500}, issn = {1944-8244}, year = {2018}, eissn = {1944-8252}, pages = {30235-30246} } @article{MTMT:31883501, title = {Polyamidoamine Dendrimer Microgels: Hierarchical Arrangement of Dendrimers into Micrometer Domains with Expanded Structural Features for Programmable Drug Delivery and Release}, url = {https://m2.mtmt.hu/api/publication/31883501}, author = {Wang, J. and Cooper, R.C. and He, H. and Li, B. and Yang, H.}, doi = {10.1021/acs.macromol.8b01006}, journal-iso = {MACROMOLECULES}, journal = {MACROMOLECULES}, volume = {51}, unique-id = {31883501}, issn = {0024-9297}, year = {2018}, eissn = {1520-5835}, pages = {6111-6118} } @article{MTMT:31883502, title = {Preparation and Characterization of Poly(L-glutamic acid)/Chitosan Nanogels}, url = {https://m2.mtmt.hu/api/publication/31883502}, author = {Yan, S. and Li, X. and Jian, Y. and Wu, N. and Teng, C. and Zhu, Y. and Yin, J.}, doi = {10.16865/j.cnki.1000-7555.2018.02.028}, journal-iso = {POLYMER MATER SCIE ENG (CHINA)}, journal = {GAOFENZI CAILIAO KEXUE YU GONGCHENG/POLYMERIC MATERIALS SCIENCE AND ENGINEERING}, volume = {34}, unique-id = {31883502}, issn = {1000-7555}, year = {2018}, pages = {168-172 and 179} } @article{MTMT:26939272, title = {Controlled release properties of zein powder filled into hard gelatin capsules}, url = {https://m2.mtmt.hu/api/publication/26939272}, author = {Berardi, Alberto and Bisharat, Lorina and Cespi, Marco and Basheti, Iman A and Bonacucina, Giulia and Pavoni, Lucia and AlKhatib, Hatim S}, doi = {10.1016/j.powtec.2017.07.093}, journal-iso = {POWDER TECHNOL}, journal = {POWDER TECHNOLOGY}, volume = {320}, unique-id = {26939272}, issn = {0032-5910}, year = {2017}, eissn = {1873-328X}, pages = {703-713} } @article{MTMT:26939274, title = {Hypoxia-induced tumor cell resistance is overcome by synergistic GAPDH-siRNA and chemotherapy co-delivered by long-circulating and cationic-interior liposomes}, url = {https://m2.mtmt.hu/api/publication/26939274}, author = {Guan, Jibin and Sun, Jin and Sun, Feilong and Lou, Bo and Zhang, Dong and Mashayekhi, Vida and Sadeghi, Negar and Storm, Gert and Mastrobattista, Enrico and He, Zhonggui}, doi = {10.1039/c7nr02663c}, journal-iso = {NANOSCALE}, journal = {NANOSCALE}, volume = {9}, unique-id = {26939274}, issn = {2040-3364}, year = {2017}, eissn = {2040-3372}, pages = {9190-9201} } @article{MTMT:26939273, title = {The In vitro/vivo Evaluation of Prepared Gastric Floating Tablets of Berberine Hydrochloride}, url = {https://m2.mtmt.hu/api/publication/26939273}, author = {Ji, Jun and He, Xin and Yang, Xiao-Lin and Du, Wen-Juan and Cui, Cheng-Long and Wang, Ling and Wang, Xue and Zhang, Chun-Feng and Guo, Chang-Run}, doi = {10.1208/s12249-016-0696-7}, journal-iso = {AAPS PHARMSCITECH}, journal = {AAPS PHARMSCITECH}, volume = {18}, unique-id = {26939273}, issn = {1530-9932}, year = {2017}, eissn = {1530-9932}, pages = {2149-2156} } @article{MTMT:26406554, title = {A new complex of copper-phosphole. Synthesis, characterization and evaluation of biological activity}, url = {https://m2.mtmt.hu/api/publication/26406554}, author = {Alfonso, Samuel and Gonzalez, Sorenlis and Higuera-Padilla, Angel R and Vidal, Alba and Fernandez, Mercedes and Taylor, Peter and Urdanibia, Izaskun and Reiber, Andreas and Otero, Yomaira and Castro, William}, doi = {10.1016/j.ica.2016.09.012}, journal-iso = {INORG CHIM ACTA}, journal = {INORGANICA CHIMICA ACTA}, volume = {453}, unique-id = {26406554}, issn = {0020-1693}, year = {2016}, eissn = {1873-3255}, pages = {538-546}, orcid-numbers = {Reiber, Andreas/0000-0001-9403-9907} } @article{MTMT:26344962, title = {Reduced Burst Release and Enhanced Oral Bioavailability in Shikimic Acid-Loaded Polylactic Acid Submicron Particles by Coaxial Electrospray}, url = {https://m2.mtmt.hu/api/publication/26344962}, author = {Wang, Miaomiao and Wang, Yuanwen and Omari-Siaw, Emmanuel and Wang, Shengli and Zhu, Yuan and Xu, Ximing}, doi = {10.1016/j.xphs.2016.05.032}, journal-iso = {J PHARM SCI}, journal = {JOURNAL OF PHARMACEUTICAL SCIENCES}, volume = {105}, unique-id = {26344962}, issn = {0022-3549}, year = {2016}, eissn = {1520-6017}, pages = {2427-2436} } @article{MTMT:25716657, title = {Preparation and In Vitro-In Vivo Evaluation of Sustained-Release Matrix Pellets of Capsaicin to Enhance the Oral Bioavailability}, url = {https://m2.mtmt.hu/api/publication/25716657}, author = {Zhang, Ya and Huang, Zhimin and Omari-Siaw, E and Lu, Shuang and Zhu, Yuan and Jiang, Dongmei and Wang, Miaomiao and Yu, Jiangnan and Xu, Ximing and Zhang, Weiming}, doi = {10.1208/s12249-015-0352-7}, journal-iso = {AAPS PHARMSCITECH}, journal = {AAPS PHARMSCITECH}, volume = {17}, unique-id = {25716657}, issn = {1530-9932}, year = {2016}, eissn = {1530-9932}, pages = {339-349} } @article{MTMT:25716658, title = {AMORPHOUS SOLID DISPERSION STUDIES OF CAMPTOTHECIN-CYCLODEXTRIN INCLUSION COMPLEXES IN PEG 6000}, url = {https://m2.mtmt.hu/api/publication/25716658}, author = {Fatmi, Sofiane and Bournine, Lamine and Iguer-Ouada, Mokrane and Lahiani-Skiba, Malika and Bouchal, Fatiha and Skiba, Mohamed}, journal-iso = {ACTA POL PHARM}, journal = {ACTA POLONIAE PHARMACEUTICA: DRUG RESEARCH}, volume = {72}, unique-id = {25716658}, issn = {0001-6837}, year = {2015}, eissn = {2353-5288}, pages = {179-192} } @article{MTMT:25716660, title = {two-step strategy to design high bioavailable controlled-release nimodipine tablets: The push-pull osmotic pump in combination with the micronization/solid dispersion techniques}, url = {https://m2.mtmt.hu/api/publication/25716660}, author = {Liu, Xiaohong and Wang, Shang and Chai, Liqing and Zhang, Dong and Sun, Yinghua and Xu, Lu and Sun, Jin}, doi = {10.1016/j.ijpharm.2013.12.023}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {461}, unique-id = {25716660}, issn = {0378-5173}, year = {2014}, eissn = {1873-3476}, pages = {529-539} } @article{MTMT:26513063, title = {Preparation and evaluation of sustained-release azithromycin tablets invitro and invivo}, url = {https://m2.mtmt.hu/api/publication/26513063}, author = {Sun, L and Zhang, W and Liu, X and Sun, J}, doi = {10.1016/j.ajps.2014.03.003}, journal-iso = {A J PHARM SCI}, journal = {ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES}, volume = {9}, unique-id = {26513063}, issn = {1818-0876}, year = {2014}, eissn = {1818-0876}, pages = {155-161} } @article{MTMT:25716659, title = {Effects of polyvinylpyrrolidone both as a binder and pore-former on the release of sparingly water-soluble topiramate from ethylcellulose coated pellets}, url = {https://m2.mtmt.hu/api/publication/25716659}, author = {Yang, Meiyan and Xie, Si and Li, Qiu and Wang, Yuli and Chang, Xinyi and Shan, Li and Sun, Lei and Huang, Xiaoli and Gao, Chunsheng}, doi = {10.1016/i.ijpharm.2014.02.021}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {465}, unique-id = {25716659}, issn = {0378-5173}, year = {2014}, eissn = {1873-3476}, pages = {187-196} } @article{MTMT:23218592, title = {An in vitro Comparison of Drug Release from Propranolol Hydrochloride Hydrophilic Matrix Tablets with SWELSTAR~(TM) MX-1 or HPMC as Matrix}, url = {https://m2.mtmt.hu/api/publication/23218592}, author = {Hu, Jin and Guo, Hong and Wang, Chenggang and Wang, Xinglin}, journal-iso = {Chinese Journal of Pharmaceuticals}, journal = {Chinese Journal of Pharmaceuticals}, volume = {44}, unique-id = {23218592}, issn = {1001-8255}, year = {2013}, pages = {249-253} } @article{MTMT:23219847, title = {Employing compritol in a mixed matrix for sustaining chlorpheniramine maleate release: Kinetic study}, url = {https://m2.mtmt.hu/api/publication/23219847}, author = {Ibrahim, MA and Fouad, EA and El-Badry, M}, journal-iso = {DIG J NANOMATER BIOS}, journal = {DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES}, volume = {8}, unique-id = {23219847}, issn = {1842-3582}, year = {2013}, eissn = {1842-3582}, pages = {737-746} } @article{MTMT:25886709, title = {Preparation of pramipexole dihydrochloride sustained-release pellets and its released behavior in vitro}, url = {https://m2.mtmt.hu/api/publication/25886709}, author = {Yuan, Z-W and Zhou, Y-B and Guan, S-X and Zhang, Y and Hu, B and He, F-M}, journal-iso = {CHINESE J NEW DRUGS}, journal = {ZHONGGUO XINYAO ZAZHI / CHINESE JOURNAL OF NEW DRUGS}, volume = {22}, unique-id = {25886709}, issn = {1003-3734}, year = {2013}, pages = {107-110} } @article{MTMT:22647778, title = {The in vitro degradation kinetics of polyurethane prodrug materials}, url = {https://m2.mtmt.hu/api/publication/22647778}, author = {Li, C and Hu, C and Wen, Z and Dong, S}, doi = {10.4028/www.scientific.net/AMR.399-401.1067}, journal-iso = {ADV MATER RES}, journal = {ADVANCED MATERIALS RESEARCH}, volume = {399-401}, unique-id = {22647778}, issn = {1022-6680}, year = {2012}, eissn = {1662-8985}, pages = {1067-1070} } @article{MTMT:22460588, title = {Preparation and in vitro/in vivo evaluation of sustained-release venlafaxine hydrochloride pellets}, url = {https://m2.mtmt.hu/api/publication/22460588}, author = {Liu, Y and Sun, Y and Sun, J and Zhao, N and Sun, M and He, Z}, doi = {10.1016/j.ijpharm.2011.12.053}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {426}, unique-id = {22460588}, issn = {0378-5173}, year = {2012}, eissn = {1873-3476}, pages = {21-28} } @article{MTMT:22647779, title = {Chitosan loaded microspheres as an ocular delivery system for acyclovir}, url = {https://m2.mtmt.hu/api/publication/22647779}, author = {Selvaraj, S and Karthikeyan, J and Saravanakumar, N}, journal-iso = {INT J PHARM PHARM SCI}, journal = {INTERNATIONAL JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES}, volume = {4}, unique-id = {22647779}, issn = {2656-0097}, year = {2012}, eissn = {0975-1491}, pages = {125-132} } @article{MTMT:23218585, title = {Preparation of gentian total glycosides intragastric floating pellets and their characteristics of in vitro release}, url = {https://m2.mtmt.hu/api/publication/23218585}, author = {Wang, Yan and Song, Xiaoling and Chen, Yinfang and Wang, Jinqian and Wang, Yuesheng and Zheng, Ying}, journal-iso = {CHINESE TRADITIONAL AND HERBAL DRUGS}, journal = {CHINESE TRADITIONAL AND HERBAL DRUGS}, volume = {43}, unique-id = {23218585}, issn = {0253-2670}, year = {2012}, pages = {1751-1755} } @article{MTMT:22460590, title = {Nanoporous multilayer poly(L-glutamic acid)/chitosan microcapsules for drug delivery}, url = {https://m2.mtmt.hu/api/publication/22460590}, author = {Yan, S and Rao, S and Zhu, J and Wang, Z and Zhang, Y and Duan, Y and Chen, X and Yin, J}, doi = {10.1016/j.ijpharm.2012.01.025}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {427}, unique-id = {22460590}, issn = {0378-5173}, year = {2012}, eissn = {1873-3476}, pages = {443-451} } @article{MTMT:1485433, title = {New formulation of in situ gelling Metolose-based liquid suppository}, url = {https://m2.mtmt.hu/api/publication/1485433}, author = {Pásztor, E and Makó, Á and Csóka, G and Fenyvesi, Z and Benkő, Rita and Prosszer, M and Marton, Sylvia and Antal, István and Klebovich, Imre}, doi = {10.3109/03639045.2010.489558}, journal-iso = {DRUG DEV IND PHARM}, journal = {DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY}, volume = {37}, unique-id = {1485433}, issn = {0363-9045}, abstract = {Context: An in situ gelling liquid suppository is liquid at room temperature but forms a gel at body temperature. In our work, Metolose® SM-4000 (methylcellulose) is studied that basically shows thermal gelation at 68°C (2, ww). Objective: The objective was to study the potency of different factors (concentration, pH, additives) to change the value of thermal gelation temperature (Tt) for Metolose® to form an in situ gelling liquid suppository. Materials and methods: We studied the effect of Metolose® concentration, pH, and salts (sodium chloride, potassium chloride, sodium hydrogen carbonate, and sodium monohydrogen phosphate) on Tt by viscosimetry. To choose the appropriate compound, in vitro drug release was examined. Rectal safety test was performed on rats in vivo after 12-hour application. Results: Increasing the Metolose® concentrations (0.54, ww), Tt can be decreased, but it also altered the consistency of gel. pH does not affect the Tt. The water-soluble salts allowed reducing the gelation temperature to 37°C. Sodium monohydrogen phosphate in 4.5 concentration was found to be the most appropriate. The impact of examined factors on in vitro drug release of piroxicam from the in situ-formed gel was characterized according to Fickian diffusion. Metolose® and the chosen salt did not cause any morphological damage on the rectal tissues. Discussion: According to our study, Metolose® has the physical and chemical potential to be used as base for liquid suppositories. © 2011 Informa UK, Ltd.}, keywords = {Animals; Male; PH; SAFETY; TEMPERATURE; RATS; ARTICLE; Models, Biological; controlled study; nonhuman; animal tissue; animal experiment; in vitro study; Rats, Wistar; Hydrogen-Ion Concentration; drug formulation; tissue injury; rectum; chemical analysis; BICARBONATE; piroxicam; Chemistry, Pharmaceutical/methods; concentration (parameters); sodium chloride; Drug release; potassium chloride; Methylcellulose/*chemistry; Gelation; Administration, Rectal; viscometry; drug diffusion; suppository base; pharmaceutical vehicles and additives; hydroxymethylcellulose; disodium hydrogen phosphate; Metolose®; In situ gelling suppository; Suppositories/*chemistry; Piroxicam/administration & dosage/*chemistry; Phosphates/*chemistry; Gels/*chemistry; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*chemistry; rat}, year = {2011}, eissn = {1520-5762}, pages = {1-7}, orcid-numbers = {Benkő, Rita/0000-0001-7740-9128; Marton, Sylvia/0000-0002-2419-3383; Antal, István/0000-0002-5434-201X; Klebovich, Imre/0000-0003-1672-5172} } @article{MTMT:21536415, title = {Development and in vitro evaluation of polar lipid based lipospheres for oral delivery of peptide drugs}, url = {https://m2.mtmt.hu/api/publication/21536415}, author = {Singh, M R and Singh, D and Swarnlata, S}, doi = {10.5138/ijdd.2009.0975.0215.01002}, journal-iso = {INT JOU DRUG DELIVERY}, journal = {INTERNATIONAL JOURNAL OF DRUG DELIVERY}, volume = {3}, unique-id = {21536415}, issn = {0975-0215}, year = {2011}, pages = {15-26} } @article{MTMT:21536414, title = {Formulation optimization of controlled delivery system for antihypertensive peptide using response surface methodology}, url = {https://m2.mtmt.hu/api/publication/21536414}, author = {Singh, M R and Singh, D and Saraf, S}, doi = {10.3923/ajdd.2011.174.187}, journal-iso = {AMERICAN JOURNAL OF DRUG DISCOVERY AND DEVELOPMENT}, journal = {AMERICAN JOURNAL OF DRUG DISCOVERY AND DEVELOPMENT}, volume = {1}, unique-id = {21536414}, issn = {2150-427X}, year = {2011}, eissn = {2150-4296}, pages = {174-187} } @article{MTMT:23708580, title = {Influence of selected formulation variables on the preparation of peptide loaded lipospheres}, url = {https://m2.mtmt.hu/api/publication/23708580}, author = {Singh, MR and Singh, D and Saraf, S}, doi = {10.3923/tmr.2011.101.115}, journal-iso = {TRENDS IN MEDICAL RESEARCH}, journal = {TRENDS IN MEDICAL RESEARCH}, volume = {6}, unique-id = {23708580}, issn = {1819-3587}, year = {2011}, eissn = {2151-6065}, pages = {101-115} } @article{MTMT:21322911, title = {Formulation optimization of metronidazole loaded chitosan microspheres for wound management by 3-factor, 3-level box-behnken design}, url = {https://m2.mtmt.hu/api/publication/21322911}, author = {Singh, D and Singh, M R and Saraf, S and Dixit, V K and Saraf, S}, doi = {10.2174/1876402911002020070}, journal-iso = {MICRO NANOSYSTEMS}, journal = {MICRO AND NANOSYSTEMS}, volume = {2}, unique-id = {21322911}, issn = {1876-4029}, year = {2010}, pages = {70-77} } @article{MTMT:21322910, title = {Optimization and characterization of gentamicin loaded chitosan microspheres for effective wound healing}, url = {https://m2.mtmt.hu/api/publication/21322910}, author = {Singh, D and Singh, M and Saraf, S and Dixit, V K and Saraf, S}, journal-iso = {INDIAN J PHARM EDUC}, journal = {INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH}, volume = {44}, unique-id = {21322910}, issn = {0019-5464}, year = {2010}, eissn = {0019-5464}, pages = {171-182} } @article{MTMT:21322913, title = {Application of new statistical approach to study drug release from OCP coating on titanium sheets}, url = {https://m2.mtmt.hu/api/publication/21322913}, author = {Fuentes, G and Peón, E and Campos, Y and López, N and Resende, C X and De Almeida, Soares G}, doi = {10.4028/0-87849-353-0.511}, journal-iso = {KEY ENG MATER}, journal = {KEY ENGINEERING MATERIALS}, volume = {396-398}, unique-id = {21322913}, issn = {1013-9826}, year = {2009}, eissn = {1662-9795}, pages = {511-514} } @article{MTMT:21322912, title = {Properties of antibiotic-loaded acrylic bone cements for use in cemented arthroplasties: A state-of-the-art review}, url = {https://m2.mtmt.hu/api/publication/21322912}, author = {Lewis, G}, doi = {10.1002/jbm.b.31220}, journal-iso = {J BIOMED MATER RES B}, journal = {JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS}, volume = {89}, unique-id = {21322912}, issn = {1552-4973}, year = {2009}, eissn = {1552-4981}, pages = {558-574} } @article{MTMT:21322914, title = {Preparation and in vitro evaluation of bovine serum albumin-loaded poly (L-lactic acid) fibers}, url = {https://m2.mtmt.hu/api/publication/21322914}, author = {Li, H and Gao, H and Gu, Y -Q}, journal-iso = {ZHONGGUO YAOKE DAXUE XUEBAO / JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY}, journal = {ZHONGGUO YAOKE DAXUE XUEBAO / JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY}, volume = {39}, unique-id = {21322914}, issn = {1000-5048}, year = {2008}, pages = {23-27} } @article{MTMT:21322915, title = {Influence of release enhancers on release of venlafaxine hydrochloride from glyceryl behenate matrix tablet}, url = {https://m2.mtmt.hu/api/publication/21322915}, author = {Patel, N M and Soniwala, M M}, journal-iso = {Indian Drugs}, journal = {Indian Drugs}, volume = {45}, unique-id = {21322915}, issn = {0019-462X}, year = {2008}, pages = {98-104} } @article{MTMT:21322917, title = {Development and in vitro evaluation of alginate gel-encapsulated, chitosan-coated ceramic nanocores for oral delivery of enzyme}, url = {https://m2.mtmt.hu/api/publication/21322917}, author = {Rawat, M and Singh, D and Saraf, S and Saraf, S}, doi = {10.1080/03639040701539479}, journal-iso = {DRUG DEV IND PHARM}, journal = {DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY}, volume = {34}, unique-id = {21322917}, issn = {0363-9045}, year = {2008}, eissn = {1520-5762}, pages = {181-188} } @article{MTMT:21322916, title = {Formulation optimization of gentamicin loaded Eudragit RS100 microspheres using factorial design study}, url = {https://m2.mtmt.hu/api/publication/21322916}, author = {Singh, D and Saraf, S and Dixit, V K and Saraf, S}, doi = {10.1248/bpb.31.662}, journal-iso = {BIOL PHARM BULL}, journal = {BIOLOGICAL & PHARMACEUTICAL BULLETIN}, volume = {31}, unique-id = {21322916}, issn = {0918-6158}, year = {2008}, eissn = {1347-5215}, pages = {662-667} } @article{MTMT:2187212, title = {Characterization and drug delivery behaviour of starch-based hydrogels prepared via isostatic ultrahigh pressure}, url = {https://m2.mtmt.hu/api/publication/2187212}, author = {Szepes, A and Makai, Z and Blumer, C and Mader, K and Kasa, P and Révész, Piroska}, doi = {10.1016/j.carbpol.2007.09.028}, journal-iso = {CARBOHYD POLYM}, journal = {CARBOHYDRATE POLYMERS}, volume = {72}, unique-id = {2187212}, issn = {0144-8617}, abstract = {The purpose of our study was to investigate the applicability of isostatic ultra high pressure (IUHP) for the aim of drug formulation. Aqueous suspensions of potato and maize starches containing theophylline as a model drug were subjected to IUHP. The changes in the structure and morphology of potato and maize starches were investigated. The release profile of theophylline from the pressurized samples was also studied. The aqueous suspensions subjected to WHIP turned into highly viscous gels. The crystalline structure of maize starch was changed, while PS pressurized in aqueous medium retained its original X-ray pattern. The sample containing potato starch as a gel-forming polymer exhibited faster drug dissolution compared to an aqueous theophylline suspension used as a reference, while the pressurization of maize starch resulted in a get exhibiting sustained drug release. The results of the dissolution study can be explained with the changes in structure and morphology of the starches caused by IUHP processing and with the different pressure sensitivities of PS and MS. (c) 2007 Elsevier Ltd. All rights reserved.}, year = {2008}, eissn = {1879-1344}, pages = {571-578}, orcid-numbers = {Révész, Piroska/0000-0002-5336-6052} } @article{MTMT:1485982, title = {A kioldódási profil jelentősége a stabilitási vizsgálatokban}, url = {https://m2.mtmt.hu/api/publication/1485982}, author = {Lengyel, Miléna and Dredán, Judit and Shafir, G and Klebovich, Imre and Antal, István}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {77}, unique-id = {1485982}, issn = {0001-6659}, abstract = {The aim of stability testing lies in its possibility of revealing all the effects that may influence the quality, efficacy and safety of a pharmaceutical preparation. The stability of a dosage form means that the release of the active ingredients remains unchanged or within specific limits. The manner of stability testing is regulated by guidelines, which consist of -- besides the regular tests of the active ingredient and the degradation products, the concerning impurities, the water content, the hardness -- the dissolution tests. Most physical changes influence the drug release in vivo, which can -- in vitro -- be followed by dissolution.}, keywords = {SAFETY; Solubility; drug stability; Water/*chemistry; Pharmaceutical Preparations/*standards}, year = {2007}, eissn = {1587-1495}, pages = {132-141}, orcid-numbers = {Lengyel, Miléna/0000-0001-8865-054X; Dredán, Judit/0000-0001-5278-8053; Klebovich, Imre/0000-0003-1672-5172; Antal, István/0000-0002-5434-201X} } @article{MTMT:2360386, title = {Appreciation of scientific researcher life of Prof. Dr. I. Rácz}, url = {https://m2.mtmt.hu/api/publication/2360386}, author = {Marton, Sylvia and Plachy, J}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {77}, unique-id = {2360386}, issn = {0001-6659}, year = {2007}, eissn = {1587-1495}, pages = {77-81}, orcid-numbers = {Marton, Sylvia/0000-0002-2419-3383} } @mastersthesis{MTMT:21325715, title = {Application of non-conventional methods in the physico-chemical processing of pharmaceutical biopolymers for the aim of drug formulation}, url = {https://m2.mtmt.hu/api/publication/21325715}, author = {Szepes, A}, unique-id = {21325715}, year = {2007} } @article{MTMT:1872173, title = {Freeze-casting technique in the development of solid drug delivery systems}, url = {https://m2.mtmt.hu/api/publication/1872173}, author = {Szepes, A and Ulrich, J and Farkas, Z and Kovács, József and Révész, Piroska}, doi = {10.1016/j.cep.2006.06.004}, journal-iso = {CHEM ENG PROCESS}, journal = {CHEMICAL ENGINEERING AND PROCESSING}, volume = {46}, unique-id = {1872173}, issn = {0255-2701}, abstract = {The aim of the present study was to develop a fast-dissolving solid dosage form containing theophylline as active ingredient using the freeze-casting technique. The structure, the physical properties and mechanism of drug release from the freeze-casted units were investigated. The examined properties of the samples were compared with those of tablets compressed by an eccentric tableting machine using three different compression pressures. The freeze-casting technique proved to be an appropriate alternative for the development of porous solid drug delivery systems. The mechanical strength of the matrices could be improved by using water-soluble additives, which stabilized the solid bodies during recrystallization upon drying. As compared with the tablets, the freeze-casted units revealed a highly porous nature and a remarkable difference in pore volume size distribution. The results demonstrated that the drug-solvent interaction, enhanced by the structural properties, resulted in a rapid delivery of the theophylline from the solid units into artificial gastric juice. © 2006 Elsevier B.V. All rights reserved.}, keywords = {Starch; CRYSTALLIZATION; scanning electron microscopy; Porosity; Crystallisation; SEM; Drug products; Drug release; Artificial gastric juice; Porous materials; Recrystallization (metallurgy); Freeze casting; Freeze-casting}, year = {2007}, eissn = {1873-3204}, pages = {230-238}, orcid-numbers = {Révész, Piroska/0000-0002-5336-6052} } @mastersthesis{MTMT:21322983, title = {Preparation and evolution of zinc sulphate matrices for individual clinical therapy of Wilson's disease}, url = {https://m2.mtmt.hu/api/publication/21322983}, author = {Nagy, Judit}, unique-id = {21322983}, year = {2005} } @article{MTMT:1466051, title = {Evaluation of dissolution profiles of polyethyleneglycol and hydroxy propyl methyl cellulose based matrix tablets}, url = {https://m2.mtmt.hu/api/publication/1466051}, author = {Pál, Szilárd and Mayer, Klára and Bodor, A and Nagy, Sándor and Dévay, Attila}, journal-iso = {EUR J PHARM SCI}, journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES}, volume = {25}, unique-id = {1466051}, issn = {0928-0987}, year = {2005}, eissn = {1879-0720}, pages = {S167-S168} } @article{MTMT:1487740, title = {Evaluation of drug liberation from "soft-patch" type gel systems by different mathematical models. Hatóanyagfelszabadulás értékelése különbözo matematikai módszerekkel új "soft-patch" típusú gélrendszerekbol}, url = {https://m2.mtmt.hu/api/publication/1487740}, author = {Csóka, G and Marton, Sylvia and Rácz, István}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {74}, unique-id = {1487740}, issn = {0001-6659}, abstract = {Authors investigate "soft-patch" type transdermal delivery gel systems with NSAID (diclofenac-Na). The matrix systems containing 1% pharmacon in dissolved (stearate gel) and in suspended form (PEG and lipophilic gel). The in vitro dissolution test was performed according to USP TTS directives. The acidic skin wrap was simulated by buffer solution of pH=5.5, the liberated and dissolved fraction of drug was determined spectrophotometrically. The rate constants were calculated using different mathematical models (first order kinetics, Fick's law, Higuchi equation, modified Nernst equation /Rácz et al./, Hixon relationship). The aim of investigations was to determine the fit of equations to measurement results, namely in which situation is the rate constant independent of time. The comparison was based on RSD and R2 values. The modified Nernst equation (Rácz's relationship) passed the best on data in the case of all three gel systems, the calculated values were constant at any time point. The shape parameter value (a) confirmed the alterations in liberation processes. The less correlation was observed in the case of Hixon-Crowel equation.}, keywords = {LIPOPHILICITY; PH; BUFFER; review; Spectrophotometry; suspension; drug delivery system; drug solubility; diclofenac; GEL; nonsteroid antiinflammatory agent; acidity; mathematical model; correlation coefficient; Drug release; stearic acid; transdermal patch; curve fitting; macrogol 4000; lard; adeps solidus 50}, year = {2004}, eissn = {1587-1495}, pages = {102-106}, orcid-numbers = {Marton, Sylvia/0000-0002-2419-3383} } @article{MTMT:1884375, title = {Iron(II) sulfate release from drop-formed lipophilic matrices developed by special hot-melt technology}, url = {https://m2.mtmt.hu/api/publication/1884375}, author = {Pallagi, Edina and Vass, K and Hódi, Klára and Kása, Péter and Falkay, G. and Erős, István and Révész, Piroska}, doi = {10.1016/j.ejpb.2003.10.017}, journal-iso = {EUR J PHARM BIOPHARM}, journal = {EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS}, volume = {57}, unique-id = {1884375}, issn = {0939-6411}, year = {2004}, eissn = {1873-3441}, pages = {287-294}, orcid-numbers = {Hódi, Klára/0000-0002-0794-1423; Kása, Péter/0000-0002-6134-0928; Révész, Piroska/0000-0002-5336-6052} } @mastersthesis{MTMT:21323029, title = {New possibilities for development of iron(II)sulfate containing solid products with sustained drug release}, url = {https://m2.mtmt.hu/api/publication/21323029}, author = {Pallagi, E}, unique-id = {21323029}, year = {2004} } @article{MTMT:21322926, title = {A novel pH-dependent gradient-release delivery system for nitrendipine: II. Investigations of the factors affecting the release behaviors of the system}, url = {https://m2.mtmt.hu/api/publication/21322926}, author = {Yang, M and Cui, F and You, B and Wang, L and Yue, P and Kawashima, Y}, doi = {10.1016/j.ijpharm.2004.08.007}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {286}, unique-id = {21322926}, issn = {0378-5173}, year = {2004}, eissn = {1873-3476}, pages = {99-109} } @article{MTMT:20970214, title = {Weibull eqation and dissolution kinetics (Wibullova rovnice a kinetika disoluce)}, url = {https://m2.mtmt.hu/api/publication/20970214}, author = {Zatloukat, Z}, journal-iso = {CESKA A SLOVENSKA FARMACIE}, journal = {CESKA A SLOVENSKA FARMACIE}, volume = {53}, unique-id = {20970214}, issn = {1210-7816}, year = {2004}, pages = {332-335} } @article{MTMT:21322923, title = {Quality evaluation of nimodipine nanoliposomes freeze-dried powder}, url = {https://m2.mtmt.hu/api/publication/21322923}, author = {Zheng, Y and Zhu, J -B}, journal-iso = {CHIN PHARMACEUT J - CHUNG YAO HSUEH TSA CHIH}, journal = {CHINESE PHARMACEUTICAL JOURNAL - CHUNG-KUO YAO HSUEH TSA CHIH}, volume = {39}, unique-id = {21322923}, issn = {1001-2494}, year = {2004}, pages = {528-531} } @article{MTMT:22647772, title = {灯盏花素骨架缓释微丸释药机制的研究}, url = {https://m2.mtmt.hu/api/publication/22647772}, author = {张彦青 and 解军波 and 陈大为}, journal-iso = {CHINESE TRADITIONAL AND HERBAL DRUGS}, journal = {CHINESE TRADITIONAL AND HERBAL DRUGS}, volume = {35}, unique-id = {22647772}, issn = {0253-2670}, year = {2004}, pages = {517-519} } @article{MTMT:1767237, title = {Effect of coating on the flow, wetting and dissolution for dimenhydrinate crystals}, url = {https://m2.mtmt.hu/api/publication/1767237}, author = {Bajdik, J and Hódi, Klára and Regdon, Géza (ifj.) and Haasner, T and Révész, Piroska and Ulrich, J and Erős, István}, journal-iso = {HUNG J IND CHEM}, journal = {HUNGARIAN JOURNAL OF INDUSTRY AND CHEMISTRY}, volume = {30}, unique-id = {1767237}, issn = {0133-0276}, abstract = {Crystals of dimenhydrinate were coated with a gastric-soluble polymer (hydroxypropyl-methylcellulose) in a fluidized bed apparatus in order to increase the poor flowabilty of crystals. The amount of coating polymer can influence the wetting, the dissolution rate of the active ingredient and the sensitivity to heat. There was an increase in particle size due to the coating, but the increase is less than that during conventional granulation. The flow properties was increased by the film coating. The different wetting behaviour of the crystals is explained in terms of the contact angle of distilled water on the surface of tablets. Here different quantities of film forming polymer were examined. The characteristic water uptake reflects the wetting of the crystals. The thermal sensitivity, determined by a differential scanning calorimetry, was improved by the coating. The quantity of the polymer in the film plays an important part in the thermal sensitivity.}, keywords = {differential scanning calorimetry; CRYSTALS; DISSOLUTION; melting; Organic compounds; Protective coatings; melting point; Wetting; Fluidized beds; dimenhydrinate; Thermal sensitivity; Gastric soluble polymer; Dimenhydrinate crystals; Coating polymer; Coating effects; Flow properties; HPMC}, year = {2002}, eissn = {2450-5102}, pages = {143-148}, orcid-numbers = {Hódi, Klára/0000-0002-0794-1423; Regdon, Géza (ifj.)/0000-0002-6921-3069; Révész, Piroska/0000-0002-5336-6052} } @article{MTMT:1767240, title = {Treatment of particles with low-flow properties}, url = {https://m2.mtmt.hu/api/publication/1767240}, author = {Bajdik, J and Hódi, Klára and Regdon, Géza (ifj.) and Erős, István}, journal-iso = {DRUGS MADE IN GERMANY}, journal = {DRUGS MADE IN GERMANY}, volume = {45}, unique-id = {1767240}, issn = {0012-6683}, abstract = {The main problems which occur during the preparation of solid dosage forms (especially tablets and capsules) are the insufficient flow of the particles, poor compactibility and inadequate stability of the materials. The aim of preformulation, therefore, is to eliminate such problems, if possible. The effects of granulation and coating were examined. Dimenhydrinate was chosen as a model drug with low-flow properties and decomposition at the melting point. The shape of the particles and the flow properties (angle of repose, mass by volume, flow time, the Hausner factor and Carr's index) were determined. Differential scanning calorimetry was used to check the features of the sample on exposure to heat and to measure the melting point. The effect of the coating film on the melting point was observed during melting.}, keywords = {FLOW; SAMPLE; review; differential scanning calorimetry; controlled study; drug stability; drug coating; drug determination; drug dosage form; Povidone; drug decomposition; drug capsule; hydroxypropylcellulose; tablet; film coating; tablet compression; drug granulation; solid; Solid dosage forms; dimenhydrinate; sepifilm lp 010; Particles, agglomeration, flow properties}, year = {2002}, pages = {25-29}, orcid-numbers = {Hódi, Klára/0000-0002-0794-1423; Regdon, Géza (ifj.)/0000-0002-6921-3069} } @article{MTMT:21322928, title = {In vitro biopharmaceutic evaluation of capsules containing fluconazole. Avaliação biofarmacêutica in vitro de cápsulas de fluconazol}, url = {https://m2.mtmt.hu/api/publication/21322928}, author = {Porta, V and Yamamichi, É and Storpirtis, S}, journal-iso = {REVISTA BRASILEIRA DE CIENCIAS FARMACEUTICAS}, journal = {REVISTA BRASILEIRA DE CIENCIAS FARMACEUTICAS}, volume = {38}, unique-id = {21322928}, issn = {1516-9332}, year = {2002}, pages = {333-343} } @article{MTMT:1488623, title = {A hatóanyag orális felszívódásának előrejelzésére alkalmazott kioldódás vizsgálatok biofarmáciai vonatkozásai}, url = {https://m2.mtmt.hu/api/publication/1488623}, author = {Antal, István}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {71}, unique-id = {1488623}, issn = {0001-6659}, abstract = {Drug dissolution is a prerequisite to drug absorption and in vivo effectiveness for almost all drugs given in oral solid dosage forms. Drug absorption depends on the dissolution and solubilization of the drug under physiological conditions, and the permeability across the gastrointestinal tract. Because of the critical nature of the first steps, in vitro dissolution may be relevant to the prediction of biological response. Dissolution tests are applied to choose between formulation factors, assess the lot-to-lot quality of a drug product according to the biobatch; and ensure continuing product quality and performance after certain changes (e.g. in the formulation and manufacturing process, site of manufacture, scale-up). The recently developed Biopharmaceutical Classification System (BCS) has several benefits for recognizing how dissolution tests can be designed and which physiological factors have to be taken into consideration for the in vitro evaluation of solid dosage forms. Choice of test conditions (composition, volume and hydrodynamics of dissolution medium) should be based on where the drug is best absorbed in the gastrointestinal tract, and on whether it is administered in fasted or fed state. Duration of test and physiologically representative media can be selected to simulate gastric and intestinal environments according to the permeability profile of the drug, but mimicking in vivo hydrodynamics remains problematic and further research is required. To provide a basis for predicting the likelihood of achieving a successful in vivo-in vitro correlation, this review summarizes the biopharmaceutical considerations of in vivo drug relase in accordance with the BCS.}, keywords = {Humans; CIMETIDINE; PARACETAMOL; review; Prognosis; metoprolol; carbamazepine; in vitro study; Administration, Oral; quality control; hydrodynamics; drug formulation; drug efficacy; gastrointestinal tract; Solutions; drug solubility; ranitidine; in vivo study; food intake; furosemide; drug absorption; Intestinal Absorption; Pharmaceutical Preparations; drug penetration; Griseofulvin; drug dosage form; Drug release; theophylline; Ketoconazole; drug manufacture; atenolol; hydrochlorothiazide}, year = {2001}, eissn = {1587-1495}, pages = {280-288}, orcid-numbers = {Antal, István/0000-0002-5434-201X} } @article{MTMT:1766912, title = {Treatment of particles with low-flow properties}, url = {https://m2.mtmt.hu/api/publication/1766912}, author = {Bajdik, J and Hódi, Klára and Regdon, Géza (ifj.) and Erős, István}, journal-iso = {PHARM IND}, journal = {PHARMAZEUTISCHE INDUSTRIE}, volume = {63}, unique-id = {1766912}, issn = {0031-711X}, year = {2001}, eissn = {1616-7074}, pages = {1197-1202}, orcid-numbers = {Hódi, Klára/0000-0002-0794-1423; Regdon, Géza (ifj.)/0000-0002-6921-3069} } @article{MTMT:21322931, title = {Gentamicin bone cements: Characterisation and release (in vitro and in vivo assays)}, url = {https://m2.mtmt.hu/api/publication/21322931}, author = {Torrado, S and Frutos, P and Frutos, G}, doi = {10.1016/S0378-5173(01)00587-7}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {217}, unique-id = {21322931}, issn = {0378-5173}, year = {2001}, eissn = {1873-3476}, pages = {57-69} } @article{MTMT:1487289, title = {Evaluation of different mathematical methods describing drug liberation from new, 'soft-patch' type matrix systems}, url = {https://m2.mtmt.hu/api/publication/1487289}, author = {Csóka, G and Dredán, Judit and Marton, Sylvia and Antal, István and Rácz, István}, doi = {10.1081/PDT-100101364}, journal-iso = {PHARM DEV TECHNOL}, journal = {PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY}, volume = {4}, unique-id = {1487289}, issn = {1083-7450}, keywords = {ARTICLE; priority journal; controlled study; in vitro study; THERMODYNAMICS; Solubility; Drug Delivery Systems; drug solubility; correlation function; Mathematics; macrogol; diclofenac; GEL; rheumatic disease; mathematical model; Anti-Inflammatory Agents, Non-Steroidal; controlled drug release; Gels; topical drug administration; stearic acid; Propylene Glycol; Stearates; witepsol w 35}, year = {1999}, eissn = {1097-9867}, pages = {291-294}, orcid-numbers = {Dredán, Judit/0000-0001-5278-8053; Marton, Sylvia/0000-0002-2419-3383; Antal, István/0000-0002-5434-201X} } @article{MTMT:1341083, title = {Effect of chemical properties on drug release from hydrophobic matrices}, url = {https://m2.mtmt.hu/api/publication/1341083}, author = {Dredán, Judit and Zelkó, Romána and Antal, István and Bihari, E and Rácz, István}, doi = {10.1016/S0378-5173(97)00354-2}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {160}, unique-id = {1341083}, issn = {0378-5173}, year = {1998}, eissn = {1873-3476}, pages = {257-260}, orcid-numbers = {Dredán, Judit/0000-0001-5278-8053; Zelkó, Romána/0000-0002-5419-9137; Antal, István/0000-0002-5434-201X} } @article{MTMT:1341088, title = {Effect of particle size and coating level on the diffuse reflectance of wax matrices}, url = {https://m2.mtmt.hu/api/publication/1341088}, author = {Dredán, Judit and Zelkó, Romána and Antal, István and Bihari, E and Rácz, István}, doi = {10.1111/j.2042-7158.1998.tb06168.x}, journal-iso = {J PHARM PHARMACOL}, journal = {JOURNAL OF PHARMACY AND PHARMACOLOGY}, volume = {50}, unique-id = {1341088}, issn = {0022-3573}, year = {1998}, eissn = {2042-7158}, pages = {139-142}, orcid-numbers = {Dredán, Judit/0000-0001-5278-8053; Zelkó, Romána/0000-0002-5419-9137; Antal, István/0000-0002-5434-201X} } @article{MTMT:1342848, title = {Poli(etilénglikol)-származékok fizikai-kémiai tulajdonságainak hatása viaszmátrixok hatóanyagleadására}, url = {https://m2.mtmt.hu/api/publication/1342848}, author = {Dredán, Judit and Zelkó, Romána and Bihari, E and Rácz, István}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {68}, unique-id = {1342848}, issn = {0001-6659}, year = {1998}, eissn = {1587-1495}, pages = {210-213}, orcid-numbers = {Dredán, Judit/0000-0001-5278-8053; Zelkó, Romána/0000-0002-5419-9137} }