TY - CONF AU - Afolalu, Sunday A. AU - Yusuf, Olabisi Omolola AU - Abioye, Abiodun A. AU - Emetere, Moses E. AU - Ongbali, Samson O. AU - Olamilekan, R. Oloyede TI - Overview of nanotechnology and their toxicities T2 - TECHNOLOGIES AND MATERIALS FOR RENEWABLE ENERGY, ENVIRONMENT AND SUSTAINABILITY: TMREES21Gr PB - AIP Publishing T3 - AIP Conference Proceedings, ISSN 0094-243X ; 2437. PY - 2022 DO - 10.1063/5.0092674 UR - https://m2.mtmt.hu/api/publication/33057787 ID - 33057787 LA - English DB - MTMT ER - TY - CHAP AU - Gaharwar, Usha Singh AU - Pardhiya, Sonali AU - Rajamani, Paulraj ED - Kesari, Kavindra Kumar ED - Roychoudhury, Shubhadeep TI - A Perspective on Reproductive Toxicity of Metallic Nanomaterials T2 - Oxidative Stress and Toxicity in Reproductive Biology and Medicine: a Comprehensive Update on Male Infertility, Volume II PB - Springer International Publishing CY - Cham SN - 9783031129667 T3 - Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 1391. PY - 2022 SP - 97 EP - 117 PG - 21 DO - 10.1007/978-3-031-12966-7_7 UR - https://m2.mtmt.hu/api/publication/33295550 ID - 33295550 LA - English DB - MTMT ER - TY - JOUR AU - Cai, Jingzeng AU - Guan, Haoyue AU - Jiao, Xing AU - Yang, Jie AU - Chen, Xiaoming AU - Zhang, Haoran AU - Zheng, Yingying AU - Zhu, Yue AU - Liu, Qi AU - Zhang, Ziwei TI - NLRP3 inflammasome mediated pyroptosis is involved in cadmium exposure-induced neuroinflammation through the IL-1 beta/IkB-alpha-NF-kappa B-NLRP3 feedback loop in swine JF - TOXICOLOGY J2 - TOXICOLOGY VL - 453 PY - 2021 PG - 10 SN - 0300-483X DO - 10.1016/j.tox.2021.152720 UR - https://m2.mtmt.hu/api/publication/32243857 ID - 32243857 AB - Cadmium (Cd) chloride, as widely distributed toxic environmental pollutants by using in industry, severely imperils animal and human health. Pyroptosis is a Cas1-dependent pro-inflammatory programmed cell death and involves in various types of diseases. Nevertheless, the mechanism of pyroptosis and Cd-induced neurotoxicity remains obscure. To investigate the specific molecular mechanisms of Cd-induced neurotoxicity, 10 weaned piglets were randomly divided into 2 groups treated with 0 and 20 mg/kg CdCl2 in the diet for 40 days. The levels of pyroptosis, mitochondrial and inflammation-related genes were validated by qRT-PCR and WB in vivo. Our results revealed that Cd caused cerebral histopathology lesions, inducing cerebral pyroptosis and the mass generation of inflammatory cytokines, as indicated by the increased NLRP3 inflammasome activation (NLRP3, Cas1 and ASC) and the upregulation of inflammation factors IL-2, IL-6, IL-7 and inhibition of IL-10. Subsequently, further research indicated that Cd triggered pyroptosis via activating the TRAF6-IkB-alpha-NF-kappa B pathway, which interfered with the phosphorylation and ubiquitination of IkB-alpha. Furthermore, Cd caused mitochondrial dysfunction and fragmentation by inhibiting the AMPK-PGC-1 alpha-NRF1/2 signaling pathway and reduced the expression of mitochondrial-related regulatory factors OPA1, TFAM and mtDNA, resulting in the increase of NLRP3 inflammasome. Besides, we found eight hub genes (IKK, IKB-alpha, NLRP3, TRAF6, NF-kappa B, AMPK, TNF alpha and PGC-1 alpha), mainly related to the interaction between the NF-kappa B pathway and NLRP3 inflammasome. Overall, these results demonstrated that Cd could promote the IL-1 beta/IkB-alpha-NF-kappa B-NLRP3 inflammasome activation positive feedback loop to result in neuroinflammation in swine, which provided new insights in understanding Cd-induced toxicity. LA - English DB - MTMT ER - TY - JOUR AU - Cui, Xuejing AU - Bao, Lin AU - Wang, Xiaoyu AU - Chen, Chunying TI - The Nano-Intestine Interaction: Understanding the Location-Oriented Effects of Engineered Nanomaterials in the Intestine JF - SMALL J2 - SMALL VL - 16 PY - 2020 IS - 21 PG - 21 SN - 1613-6810 DO - 10.1002/smll.201907665 UR - https://m2.mtmt.hu/api/publication/31455026 ID - 31455026 AB - Engineered nanomaterials (ENMs) are used in food additives, food packages, and therapeutic purposes owing to their useful properties, Therefore, human beings are orally exposed to exogenous nanomaterials frequently, which means the intestine is one of the primary targets of nanomaterials. Consequently, it is of great importance to understand the interaction between nanomaterials and the intestine. When nanomaterials enter into gut lumen, they inevitably interact with various components and thereby display different effects on the intestine based on their locations; these are known as location-oriented effects (LOE). The intestinal LOE confer a new biological-effect profile for nanomaterials, which is dependent on the involvement of the following biological processes: nano-mucus interaction, nano-intestinal epithelial cells (IECs) interaction, nano-immune interaction, and nano-microbiota interaction. A deep understanding of NM-induced LOE will facilitate the design of safer NMs and the development of more efficient nanomedicine for intestine-related diseases. Herein, recent progress in this field is reviewed in order to better understand the LOE of nanomaterials. The distant effects of nanomaterials coupling with microbiota are also highlighted. Investigation of the interaction of nanomaterials with the intestine will stimulate other new research areas beyond intestinal nanotoxicity. LA - English DB - MTMT ER - TY - JOUR AU - Sawicki, Krzysztof AU - Czajka, Magdalena AU - Matysiak-Kucharek, Magdalena AU - Fal, Berta AU - Drop, Bartłomiej AU - Męczyńska-Wielgosz, Sylwia AU - Sikorska, Katarzyna AU - Kruszewski, Marcin AU - Kapka-Skrzypczak, Lucyna TI - Toxicity of metallic nanoparticles in the central nervous system JF - NANOTECHNOLOGY REVIEWS J2 - NANOTECHNOL REV VL - 8 PY - 2019 IS - 1 SP - 175 EP - 200 PG - 26 SN - 2191-9089 DO - 10.1515/ntrev-2019-0017 UR - https://m2.mtmt.hu/api/publication/30914745 ID - 30914745 N1 - Institute of Rural Health, Department of Molecular Biology and Translational Research, Lublin, 20-090, Poland University of Information Technology and Management, Faculty of Medicine, Department of Medical Biology and Translational Research, Rzeszow, 35-225, Poland Department of Medical Informatics and Statistics, E-learning Lab, Medical University of Lublin, Lublin, 20-090, Poland Institute of Nuclear Chemistry and Technology, Centre for Radiobiology and Biological Dosimetry, Warsaw, 03-195, Poland Cited By :17 Export Date: 9 April 2021 Correspondence Address: Sawicki, K.; Institute of Rural Health, Poland; email: krzysztofsawicki555@gmail.com Funding details: DEC-2013/09/B/NZ7/03934, DEC-2014/15/B/NZ7/01036 Funding text 1: This study was financed by the National Science Centre Fund Projects No. DEC-2013/09/B/NZ7/03934 and No. DEC-2014/15/B/NZ7/01036. Funding text 2: This study was financed by the National Science Centre Fund Projects No. DEC-2013/09/B/NZ7/03934 and No. DEC-2014/15/B/NZ7/01036. LA - English DB - MTMT ER - TY - THES AU - Kozma, Gábor TI - Nanoszerkezetek mechanikémiai előállítása és módosítási lehetőségeinek vizsgálata PY - 2017 SP - 114 UR - https://m2.mtmt.hu/api/publication/27223573 ID - 27223573 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Yang, Y AU - Qin, Z AU - Zeng, W AU - Yang, T AU - Cao, Y AU - Mei, C AU - Kuang, Y TI - Toxicity assessment of nanoparticles in various systems and organs JF - NANOTECHNOLOGY REVIEWS J2 - NANOTECHNOL REV VL - 6 PY - 2017 IS - 3 SP - 279 EP - 289 PG - 11 SN - 2191-9089 DO - 10.1515/ntrev-2016-0047 UR - https://m2.mtmt.hu/api/publication/26790456 ID - 26790456 LA - English DB - MTMT ER - TY - JOUR AU - Sathya, T N AU - Deepa, V TI - Assessment of the in vitro Skin Irritation Potential of Nanoparticles Using the Reconstructed Human Epidermis (RHE) Model JF - Advances in life sciences J2 - Advances in life sciences VL - 1 PY - 2014 IS - 2 SP - 75 EP - 83 PG - 9 SN - 2278-3849 UR - https://m2.mtmt.hu/api/publication/27229817 ID - 27229817 LA - English DB - MTMT ER - TY - JOUR AU - Lukose, Reni Mullukattil TI - Toxic Effect of Nanoparticles of Metals (Pb, Cd, Ag, Mn, Fe and Zn) and Metal Oxides (ZnO, CuO, TiO2 and CeO2) in Human Body JF - ASIAN JOURNAL OF RESEARCH IN CHEMISTRY J2 - ASIAN J RES CHEM VL - 6 PY - 2013 IS - 12 SP - 1179 EP - 1182 PG - 4 SN - 0974-4169 UR - https://m2.mtmt.hu/api/publication/24199834 ID - 24199834 LA - English DB - MTMT ER - TY - CHAP AU - Carageorgiou, Haris AU - Katramadou, Myrto ED - Li, Yang V. ED - Zhang, John H. TI - Aspects of cadmium neurotoxicity T2 - Metal Ion in Stroke PB - Springer New York CY - New York, New York SN - 9781441996633 T3 - Springer Series in Translational Stroke Research ; 13. PB - Springer New York PY - 2012 SP - 703 EP - 749 PG - 47 DO - 10.1007/978-1-4419-9663-3_33 UR - https://m2.mtmt.hu/api/publication/26790160 ID - 26790160 LA - English DB - MTMT ER - TY - JOUR AU - Horváth, Edina AU - Máté, Zsuzsanna AU - Takács, Szabolcs Ferenc AU - Pusztai, Péter AU - Sápi, András AU - Kónya, Zoltán AU - Nagymajtényi, László AU - Papp, András TI - General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form JF - SCIENTIFIC WORLD JOURNAL J2 - SCI WORLD J VL - 2012 PY - 2012 PG - 7 SN - 1537-744X DO - 10.1100/2012/520632 UR - https://m2.mtmt.hu/api/publication/2112173 ID - 2112173 LA - English DB - MTMT ER - TY - THES AU - Máté, Zsuzsanna TI - General and nervous system effects of the neurotoxic and metal manganese under various circumstances of application PB - Szegedi Tudományegyetem (SZTE) PY - 2012 SP - 60 DO - 10.14232/phd.1489 UR - https://m2.mtmt.hu/api/publication/2785837 ID - 2785837 LA - English DB - MTMT ER - TY - JOUR AU - Szalay, Brigitta AU - Tatrai, E AU - Nyírő, Gábor AU - Vezér, Tünde AU - Dura, G TI - Potential toxic effects of iron oxide nanoparticles in in vivo and in vitro experiments JF - JOURNAL OF APPLIED TOXICOLOGY J2 - J APPL TOXICOL VL - 32 PY - 2012 IS - 6 SP - 446 EP - 453 PG - 8 SN - 0260-437X DO - 10.1002/jat.1779 UR - https://m2.mtmt.hu/api/publication/1847652 ID - 1847652 AB - The aim of this study was to determine the potential toxic effects of iron(II,III)oxide nanoparticles (IONPs). In in vivo experiments, the toxic effects of IONPs were monitored in adult male Wistar rats by morphological methods after a single intratracheal instillation. For the control group 1 ml of physiological saline per animal was given, and the treatment group received the same volume of a suspension containing 1 and 5 mg kg(-1) body weight IONPs. Lungs and internal organs underwent histopathological examination after 1, 3, 7, 14 and 30 days. The mutagenic effect of these nanoparticles was evaluated by the bacterial reverse mutation assay on Salmonella typhimurium TA98, TA100, TA1535 and TA1537 strains, and on Escherichia coli WP2uvrA strain, in the presence and absence of the mammalian metabolic activation system S9. The in vitro cytotoxic effect of IONPs was also examined in Vero cells after short-term (4 h) and long-term (24 h) exposure. There were no pathological changes in examined internal organs, except a very weak pulmonary fibrosis developing by the end of the first month in the treated rats. While in vitro MTT assay showed a moderate cytotoxic effect, IONPs proved to be devoid of mutagenic effect in the bacterial systems tested. The results may be a useful extension of our knowledge on the safety of magnetite nanoparticles in view of their possible medical applications, such as in hyperthermia and magnetic resonance imaging. Copyright (c) 2011 John Wiley & Sons, Ltd. LA - English DB - MTMT ER - TY - THES AU - Szalay, Brigitta TI - Iron oxide nanoparticles and their toxicological effects: in vivo and in vitro studies PB - Szegedi Tudományegyetem (SZTE) PY - 2012 SP - 44 DO - 10.14232/phd.1422 UR - https://m2.mtmt.hu/api/publication/2785868 ID - 2785868 LA - English DB - MTMT ER - TY - THES AU - Horváth, Edina TI - Neurotoxicity of a modelled complex environmental heavy metal exposure in rats PB - Szegedi Tudományegyetem (SZTE) PY - 2011 SP - 69 DO - 10.14232/phd.1299 UR - https://m2.mtmt.hu/api/publication/1937292 ID - 1937292 LA - English DB - MTMT ER - TY - JOUR AU - Shafran, L M AU - Pykhtieieva, E G TI - Role of Metallothionein in the nervous system JF - TRACE ELEMENTS IN MEDICINE (Moscow) J2 - TRACE ELEMENTS IN MEDICINE (Moscow) VL - 12 PY - 2011 IS - 3-4 SP - 22 EP - 26 PG - 5 SN - 1607-9957 UR - https://m2.mtmt.hu/api/publication/24199811 ID - 24199811 LA - English DB - MTMT ER -