@article{MTMT:32417393,
	title = {Vitamin C Deficiency in the Young Brain-Findings from Experimental Animal Models},
	url = {https://m2.mtmt.hu/api/publication/32417393},
	author = {Tveden-Nyborg, Pernille},
	doi = {10.3390/nu13051685},
	journal-iso = {NUTRIENTS},
	journal = {NUTRIENTS},
	volume = {13},
	unique-id = {32417393},
	abstract = {Severe and long-term vitamin C deficiency can lead to fatal scurvy, which is fortunately considered rare today. However, a moderate state of vitamin C (vitC) deficiency (hypovitaminosis C)-defined as a plasma concentration below 23 mu M-is estimated to affect up to 10% of the population in the Western world, albeit clinical hallmarks in addition to scurvy have not been linked to vitC deficiency. The brain maintains a high vitC content and uniquely high levels during deficiency, supporting vitC's importance in the brain. Actions include both antioxidant and co-factor functions, rendering vitamin C deficiency likely to affect several targets in the brain, and it could be particularly significant during development where a high cellular metabolism and an immature antioxidant system might increase sensitivity. However, investigations of a non-scorbutic state of vitC deficiency and effects on the developing young brain are scarce. This narrative review provides a comprehensive overview of the complex mechanisms that regulate vitC homeostasis in vivo and in the brain in particular. Functions of vitC in the brain and the potential consequences of deficiency during brain development are highlighted, based primarily on findings from experimental animal models. Perspectives for future investigations of vitC are outlined.},
	keywords = {Brain; DEFICIENCY; Development; vitamin C},
	year = {2021},
	eissn = {2072-6643},
	orcid-numbers = {Tveden-Nyborg, Pernille/0000-0002-5574-5742}
}

@article{MTMT:24658271,
	title = {Vitamin C is not essential for carnitine biosynthesis in vivo: Verification in vitamin C-depleted senescence marker protein-30/gluconolactonase knockout mice},
	url = {https://m2.mtmt.hu/api/publication/24658271},
	author = {Furusawa, Hajime and Sato, Yasunori and Tanaka, Yasukazu and Inai, Yoko and Amano, Akiko and Iwama, Mizuki and Kondo, Yoshitaka and Handa, Setsuko and Murata, Akira and Nishikimi, Morimitsu and Goto, Sataro and Maruyama, Naoki and Takahashi, Ryoya and Ishigami, Akihito},
	doi = {10.1248/bpb.31.1673},
	journal-iso = {BIOL PHARM BULL},
	journal = {BIOLOGICAL & PHARMACEUTICAL BULLETIN},
	volume = {31},
	unique-id = {24658271},
	issn = {0918-6158},
	year = {2008},
	eissn = {1347-5215},
	pages = {1673-1679}
}

@article{MTMT:1426924,
	title = {Effect of aromatic ring-containing drugs on carnitine biosynthesis in rats with special regard to p-aminomethylbenzoic acid.},
	url = {https://m2.mtmt.hu/api/publication/1426924},
	author = {Debreceni, Balázs and Farkas, Viktória and Fischer, GM and Sándor, Attila},
	doi = {10.1016/j.metabol.2005.06.004},
	journal-iso = {METABOLISM},
	journal = {METABOLISM-CLINICAL AND EXPERIMENTAL},
	volume = {54},
	unique-id = {1426924},
	issn = {0026-0495},
	abstract = {Secondary carnitine deficiencies are associated with metabolic disorders or may be the consequence of the side effects of some drugs. The mechanisms may be either a facilitated urinary excretion or an inhibited biosynthesis. Based on our earlier findings with drugs and benzoic acid analogue metabolites, in the present study, we studied the possible inhibitory effect of some benzoic acid analogue drugs. In the pathway of carnitine biosynthesis, we tested the last step, the hydroxylation of gamma-butyrobetaine (Bu) to carnitine in the liver. (Liver is the only organ in rats where this step takes place.) Of the 5 tested compounds, the p-aminomethylbenzoic acid (PAMBA) was found to be inhibitory. In tracer experiments with radioactive Bu, PAMBA (a single injection of 1.2 mmol/kg) reduced the conversion of [Me-(3)H]Bu to [Me-(3)H]carnitine from 62.6% +/- 5.11% to 46.8% +/- 5.02% (means +/- SEM, P < .02). This single dose also markedly reduced the conversion of loading amount of exogenous unlabeled Bu, as measured by enzymatic analysis of carnitine. The conversion of endogenous Bu was also hampered by long-term administration of PAMBA, as indicated by increased Bu and decreased carnitine levels. Furthermore, single injection of PAMBA markedly reduced the Glu level in the liver from 2.87 +/- 0.17 to 1.42 +/- 0.11 mumol/g (P < .001). Trying to get closer to a mechanism by which the flux through the Bu hydroxylase was depressed, we supposed that alfa-ketoglutarate (alpha-KG), an obligatory cofactor of the enzyme, was also be depressed. It was expected because alpha-KG is a reversible copartner of l-glutamate through the Glu-dehydrogenase reaction. We found that PAMBA reduced the alpha-KG level from 207 +/- 17.5 to 180 +/- 19.1 nmol/g (means +/- SEM, P < .02). Considering the conditions of the enzyme in vitro and in vivo, this decrease may contribute to the decreased in vivo flux through the butyrobetaine hydroxylase enzyme.},
	keywords = {Animals; Male; RATS; Rats, Wistar; Hydroxylation; Ketoglutaric Acids/metabolism; Carnitine/*biosynthesis/metabolism; Betaine/analogs & derivatives/metabolism; 4-Aminobenzoic Acid/*analogs & derivatives/pharmacology},
	year = {2005},
	eissn = {1532-8600},
	pages = {1582-1586}
}

@article{MTMT:24658273,
	title = {Urinary carnitine excretion increases during experimental vitamin C depletion of healthy men},
	url = {https://m2.mtmt.hu/api/publication/24658273},
	author = {Jacob, RA and Pianalto, FS},
	doi = {10.1016/S0955-2863(97)89663-5},
	journal-iso = {J NUTR BIOCHEM},
	journal = {JOURNAL OF NUTRITIONAL BIOCHEMISTRY},
	volume = {8},
	unique-id = {24658273},
	issn = {0955-2863},
	year = {1997},
	eissn = {1873-4847},
	pages = {265-269}
}

@article{MTMT:24658274,
	title = {Vitamin C depletion is associated with alterations in blood histamine and plasma free carnitine in adults},
	url = {https://m2.mtmt.hu/api/publication/24658274},
	author = {Johnston, CS and Solomon, RE and Corte, C},
	journal-iso = {J AM COLL NUTR},
	journal = {JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION},
	volume = {15},
	unique-id = {24658274},
	issn = {0731-5724},
	year = {1996},
	eissn = {1541-1087},
	pages = {586-591}
}

@article{MTMT:24658277,
	title = {EFFECT OF VITAMIN-C ON LIPID AND CARNITINE METABOLISM IN RAINBOW-TROUT},
	url = {https://m2.mtmt.hu/api/publication/24658277},
	author = {MIYASAKI, T and SATO, M and YOSHINAKA, R and SAKAGUCHI, M},
	doi = {10.2331/fishsci.61.501},
	journal-iso = {FISHERIES SCI},
	journal = {FISHERIES SCIENCE},
	volume = {61},
	unique-id = {24658277},
	issn = {0919-9268},
	year = {1995},
	eissn = {1444-2906},
	pages = {501-506}
}

@article{MTMT:24658276,
	title = {Renal handling of carnitine in experimental vitamin C deficiency},
	url = {https://m2.mtmt.hu/api/publication/24658276},
	author = {Rebouche, CJ},
	doi = {10.1016/0026-0495(95)90087-X},
	journal-iso = {METABOLISM},
	journal = {METABOLISM-CLINICAL AND EXPERIMENTAL},
	volume = {44},
	unique-id = {24658276},
	issn = {0026-0495},
	year = {1995},
	eissn = {1532-8600},
	pages = {1639-1643}
}

@article{MTMT:24658275,
	title = {THE ABILITY OF GUINEA-PIGS TO SYNTHESIZE CARNITINE AT A NORMAL RATE FROM EPSILON-N-TRIMETHYLLYSINE OR GAMMA-BUTYROBETAINE IN-VIVO IS NOT COMPROMISED BY EXPERIMENTAL VITAMIN-C-DEFICIENCY},
	url = {https://m2.mtmt.hu/api/publication/24658275},
	author = {REBOUCHE, CJ},
	doi = {10.1016/0026-0495(95)90120-5},
	journal-iso = {METABOLISM},
	journal = {METABOLISM-CLINICAL AND EXPERIMENTAL},
	volume = {44},
	unique-id = {24658275},
	issn = {0026-0495},
	year = {1995},
	eissn = {1532-8600},
	pages = {624-629}
}

@article{MTMT:24658278,
	title = {ASCORBIC-ACID AND CARNITINE BIOSYNTHESIS},
	url = {https://m2.mtmt.hu/api/publication/24658278},
	author = {REBOUCHE, CJ},
	journal-iso = {AM J CLIN NUTR},
	journal = {AMERICAN JOURNAL OF CLINICAL NUTRITION},
	volume = {54},
	unique-id = {24658278},
	issn = {0002-9165},
	year = {1991},
	eissn = {1938-3207},
	pages = {S1147-S1152}
}

@article{MTMT:24658279,
	title = {CARNITINE - METABOLISM, FUNCTION AND CLINICAL-APPLICATION},
	url = {https://m2.mtmt.hu/api/publication/24658279},
	author = {HAECKEL, R and KAISER, E and OELLERICH, M and SILIPRANDI, N},
	journal-iso = {J CLIN CHEM CLIN BIOCHEM},
	journal = {JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY},
	volume = {28},
	unique-id = {24658279},
	issn = {0340-076X},
	year = {1990},
	pages = {291-295}
}