TY - JOUR AU - Avdeliodi, Efterpi AU - Tsioli, Anastasia AU - Bokias, Georgios AU - Kallitsis, Joannis K. TI - Controlling the Synthesis of Polyurea Microcapsules and the Encapsulation of Active Diisocyanate Compounds JF - POLYMERS J2 - POLYMERS-BASEL VL - 16 PY - 2024 IS - 2 PG - 17 SN - 2073-4360 DO - 10.3390/polym16020270 UR - https://m2.mtmt.hu/api/publication/34585988 ID - 34585988 AB - The encapsulation of active components is currently used as common methodology for the insertion of additional functions like self-healing properties on a polymeric matrix. Among the different approaches, polyurea microcapsules are used in different applications. The design of polyurea microcapsules (MCs) containing active diisocyanate compounds, namely isophorone diisocyanate (IPDI) or hexamethylene diisocyanate (HDI), is explored in the present work. The polyurea shell of MCs is formed through the interfacial polymerization of oil-in-water emulsions between the highly active methylene diphenyl diisocyanate (MDI) and diethylenetriamine (DETA), while the cores of MCs contain, apart from IPDI or HDI, a liquid Novolac resin. The hydroxyl functionalities of the resin were either unprotected (Novolac resin), partially protected (Benzyl Novolac resin) or fully protected (Acetyl Novolac resin). It has been found that the formation of MCs is controlled by the MDI/DETA ratio, while the shape and size of MCs depends on the homogenization rate applied for emulsification. The encapsulated active compound, as determined through the titration of isocyanate (NCO) groups, was found to decrease with the hydroxyl functionality content of the Novolac resin used, indicating a reaction between NCO and the hydroxyl groups. Through the thorough investigation of the organic phase, the rapid reaction (within a few minutes) of MDI with the unprotected Novolac resin was revealed, while a gradual decrease in the NCO groups (within two months) has been observed through the evolution of the Attenuated Total Reflectance-Fourier-Transform Infrared (ATR-FTIR) spectroscopy and titration, due to the reaction of these groups with the hydroxyl functionalities of unprotected and partially protected Novolac resin. Over longer times (above two months), the reaction of the remaining NCO groups with humidity was evidenced, especially when the fully protected Acetyl Novolac resin was used. HDI was found to be more susceptible to reactions, as compared with IPDI. LA - English DB - MTMT ER - TY - JOUR AU - Qari, Mohammed AU - Harakeh, Steve AU - Akefe, Isaac O. AU - Saber, Saber H. AU - Al-Raddadi, Rajaa AU - Abd Elmageed, Zakaria Y. AU - Alamri, Turki AU - El-Shitany, Nagla AU - Ali, Soad S. AU - Almuhayawi, Mohammed S. AU - Mousa, Shaker TI - Pomegranate nanoparticle mitigates cisplatin-induced testicular toxicity and improves cisplatin anti-cancer efficacy in Ehrlich carcinoma model JF - JOURNAL OF KING SAUD UNIVERSITY - SCIENCE J2 - J KING SAUD UNIV SCI VL - 35 PY - 2023 IS - 4 PG - 8 SN - 1018-3647 DO - 10.1016/j.jksus.2023.102631 UR - https://m2.mtmt.hu/api/publication/34242731 ID - 34242731 AB - Cisplatin (CISP) ranks among the most used chemo-therapeutic agents with exceptional efficacy against testicular cancer among other diverse types of cancers. However, it has been associated with nephrotox-icity among other side effects. Pomegranate (PE) is an effective anti-inflammatory and antioxidant com-pound, protecting against several chemotherapy-linked toxicities. The use of PE are limited due to its low bioavailability and poor solubility. We investigated the potential of a novel nanoparticle (NP) encapsulat-ing PE formulation to surmount its poor solubility, improve its bioavailability, and augment its protective efficacy against CISP-induced testicular toxicity in an Ehrlich solid carcinoma (ESC) mice model. All ani-mals were randomly grouped into four treatment groups: 1) control, 2) tumor, 3) CISP, and 4) CISP + PE -NPs. The results obtained demonstrated that PE-NPs efficiently prevented testicular toxicity induced by CISP in ESC mice and enhanced its functions. PE-NPs effectively improved CISP-induced oxidative stress in testicular tissues by elevating the levels of antioxidants (GSH, SOD and CAT). Importantly, PE-NPs, also, substantially decreased testicular inflammation induced by CISP, via reducing the levels of IL-1b, TNF-a, and NF-kB. PE-NPs did not impede the CISP's antitumor activity as shown by histological examination data and tumor weight. It is, therefore, conceivable that PE-NPs may serve as an adjuvant therapy to CISP in the treatment of cancer, to ameliorate the associated testicular toxicity and other unwanted effects without compromising the antitumor efficacy of CISP.& COPY; 2023 Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). LA - English DB - MTMT ER - TY - JOUR AU - Alkholief, Musaed AU - Abul Kalam, Mohd AU - Anwer, Md Khalid AU - Alshamsan, Aws TI - Effect of Solvents, Stabilizers and the Concentration of Stabilizers on the Physical Properties of Poly(d,l-lactide-co-glycolide) Nanoparticles: Encapsulation, In Vitro Release of Indomethacin and Cytotoxicity against HepG2-Cell JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 4 PG - 29 SN - 1999-4923 DO - 10.3390/pharmaceutics14040870 UR - https://m2.mtmt.hu/api/publication/32942871 ID - 32942871 AB - A biocompatible, biodegradable and FDA-approved polymer [Poly lactic-co-glycolic acid (PLGA)] was used to prepare the nanoparticles (NPs) to observe the effect of solvents, stabilizers and their concentrations on the physical properties of the PLGA-NPs, following the encapsulation and in vitro release of Indomethacin (IND). PLGA-NPs were prepared by the single-emulsion solvent evaporation technique using dichloromethane (DCM)/chloroform as the organic phase with Polyvinyl-alcohol (PVA)/Polyvinylpyrrolidone (PVP) as stabilizers to encapsulate IND. The effects of different proportions of PVA/PVP with DCM/chloroform on the physiochemical properties (particle size, the polydispersity index, the zeta potential by Malvern Zetasizer and morphology by SEM) of the NPs were investigated. DSC was used to check the physical state, the possible complexation of PLGA with stabilizer(s) and the crystallinity of the encapsulated drug. Stabilizers at all concentrations produced spherical, regular-shaped, smooth-surfaced discrete NPs. Average size of 273.2-563.9 nm was obtained when PVA (stabilizer) with DCM, whereas it ranged from 317.6 to 588.1 nm with chloroform. The particle size was 273.2-563.9 nm when PVP was the stabilizer with DCM, while it was 381.4-466.6 nm with chloroform. The zeta potentials of PVA-stabilized NPs were low and negative (-0.62 mV) while they were comparatively higher and positive for PVP-stabilized NPs (+17.73 mV). Finally, drug-loaded optimal NPs were composed of PLGA (40 mg) and IND (4 mg) in 1 mL DCM/chloroform with PVA/PVP (1-3%), which resulted in sufficient encapsulation (54.94-74.86%) and drug loading (4.99-6.81%). No endothermic peak of PVA/PVP appeared in the optimized formulation, which indicated the amorphous state of IND in the core of the PLGA-NPs. The in vitro release study indicated a sustained release of IND (32.83-52.16%) from the PLGA-NPs till 72 h and primarily followed the Higuchi matrix release kinetics followed by Korsmeyer-Peppas models. The cell proliferation assay clearly established that the organic solvents used to prepare PLGA-NPs had evaporated. The PLGA-NPs did not show any particular toxicity in the HepG2 cells within the dose range of IND (250-500 mu g/mL) and at an equivalent concentration of PLGA-NPs (3571.4-7142.7 mu g/mL). The cytotoxicity of the hepatotoxic drug (IND) was reduced by its encapsulation into PLGA-NPs. The outcomes of this investigation could be implemented to prepare PLGA-NPs of acceptable properties for the encapsulation of low/high molecular weight drugs. It would be useful for further in vitro and in vivo applications to use this delivery system. LA - English DB - MTMT ER - TY - JOUR AU - Chau Ngoc Mai, null AU - La Thi Thai Ha, null AU - Nguyen Kieu Oanh, null TI - Synthesis of polyurethane/polyurea microcapsules carrying diisocyanate in self-healing epoxy coating JF - VIETNAM JOURNAL OF CHEMISTRY J2 - VIET J CHEM VL - 60 PY - 2022 IS - 2 SP - 257 EP - 265 PG - 9 SN - 0866-7144 DO - 10.1002/vjch.202100114 UR - https://m2.mtmt.hu/api/publication/32942872 ID - 32942872 AB - Recently, self-healing coating has been emerged and become one of the most crucial and critical materials with an excellent potential to repair physical damage and prevent cracks from expansion as an anticorrosion element to lengthen the coating lifespan. The determining factor in self-healing coating is that the microcapsules containing a self-curing liquid, which quickly fills up the cracks when the coatings are cut. Microcapsule embracing isophorone diisocyanate (IPDI) as a strong self-healing agent requiring no catalyst has been continuously innovated to be utilized in reality; however, its core content is still low (50-70 %) and the effects on it were not systematically investigated. Therefore, this study aimed to synthesize polyurethane/polyurea microcapsules carrying a higher content of IPDI to be potentially applied in self-healing epoxy coating. As a result, the newly developed spherical microcapsules were obtained with a core content of nearly 80 %, which is far higher than previous research. Moreover, the self-healing ability of epoxy coating containing 10 wt.% of these microcapsules was apparently demonstrated as illustrated in SEM images, along with its excellent anticorrosion, preventing 92.5 % of cracks from corrosion after immersed in 3.5 % NaCl solution for 72 hours. LA - English DB - MTMT ER - TY - JOUR AU - Efterpi, Avdeliodi AU - Amaia, Soto Beobide AU - George, A. Voyiatzis AU - Georgios, Bokias AU - Kallitsi, Joannis K. TI - Novolac-based microcapsules containing isocyanate reagents for self-healing applications JF - PROGRESS IN ORGANIC COATINGS J2 - PROG ORG COAT VL - 173 PY - 2022 PG - 13 SN - 0300-9440 DO - 10.1016/j.porgcoat.2022.107204 UR - https://m2.mtmt.hu/api/publication/33849050 ID - 33849050 AB - Microcapsules (MCs) containing isocyanate compounds for use as self-healing materials in waterborne polyurethane coatings have been synthesized, in the presence of modified Novolac resins. With modification of Novolac resin, it is succeeded partial or total protection (Benzylation and Acetylation) of its hydroxyl groups. The idea here is to use a protected Novolac resin as the organic substrate for the encapsulation of the less reactive Isophorone isocyanate (IPDI) while the more reactive one, Methylene diphenyl diisocyanate (MDI), is used for the shell formation. Based on that strategy microcapsules of different morphologies and sizes were obtained, depending on the agitation conditions, as revealed using SEM and optical microscopy. Selective extraction was performed to determine the amount of the less reactive isocyanate (IPDI) stored inside the capsules through FTIR-ATR spectroscopy and isocyanate titration as well as the stability of IPDI inside the capsules over time. As determined, microcapsules based on Acetyl-modified Novolac resin encapsulated 96 wt% of IPDI monomer; this amount is about five and ten times higher than that encapsulated in MCs based on by Benzyl-modified Novolac resin or unprotected Novolac resin, respectively. At the same time, MCs based on Acetyl-modified Novolac resin were stable, maintaining approximately 80 % of the initial isocyanate content after two months of storage under inert conditions. Finally, the self-healing ability of the microcapsules was tested by adding selected IPDI-loaded microcapsules in waterborne polyurethane dispersions. It was proven that the Acetyl-modified Novolac-based MCs showed efficient healing behavior, in the absence of any catalyst, on the polyurethanes' surfaces when scratched artificially. LA - English DB - MTMT ER - TY - JOUR AU - Harakeh, Steve AU - Almuhayawi, Mohammed S. AU - Akefe, Isaac O. AU - Saber, Saber H. AU - Al Jaouni, Soad K. AU - Alzughaibi, Torki AU - Almehmadi, Yousef AU - Ali, Soad Shaker AU - Bharali, Dhruba J. AU - Mousa, Shaker TI - Novel Pomegranate-Nanoparticles Ameliorate Cisplatin-Induced Nephrotoxicity and Improves Cisplatin Anti-Cancer Efficacy in Ehrlich Carcinoma Mice Model JF - MOLECULES J2 - MOLECULES VL - 27 PY - 2022 IS - 5 PG - 14 SN - 1420-3049 DO - 10.3390/molecules27051605 UR - https://m2.mtmt.hu/api/publication/32942873 ID - 32942873 AB - Cisplatin (CISP) is one of the most widely used anti-cancer chemotherapeutic agents with remarkable efficacy against various types of cancers. However, it has been associated with nephrotoxicity amongst other undesirable side effects. Pomegranate (PE) is a potent antioxidant and anti-inflammatory agent effective against cancer, with a superior benefit of not being associated with the common toxicities related to the use of conventional chemotherapeutic agents. However, the application of PE is limited by its reduced solubility and decreased bioavailability. We investigated the potential of a novel nanoparticle (NP) enclosing PE to enhance its solubility and improve its bioavailability, and efficacy to prevent CISP-associated nephrotoxicity in a mice model of Ehrlich solid carcinoma (ESC). All mice were grouped into four cohorts: (I) control, (II) tumor, (III) CISP, and (IV) CISP + PE-NPs. The data obtained demonstrated that PE-NPs was beneficial in potently ameliorating CISP-induced nephrotoxicity in ESC mice. PE-NPs significantly attenuated CISP-induced oxidative stress and lipid peroxidation in the kidney via improving activities of antioxidants (SOD, GSH, and CAT). Additionally, PE-NPs considerably decreased CISP-induced inflammation in the kidney by decreasing the levels of NF-kB, IL-1 beta, and TNF-alpha. Notably, PE-NPs did not assuage the antitumor efficacy of CISP as revealed by histological assessment and tumor weight data. In summary, PE-NPs may be a potent alternative anticancer therapy devoid of nephrotoxicity. LA - English DB - MTMT ER - TY - JOUR AU - Harkaeh, S. AU - Qari, Y. AU - Tashkandi, H. AU - Almuhayawi, M. AU - Saber, S.H. AU - aljahdali, E. AU - El-Shitany, N. AU - Shaker, S. AU - Lucas, F. AU - Alamri, T. AU - Al-Jaouni, S. AU - Mousa, S. TI - Thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy JF - JOURNAL OF KING SAUD UNIVERSITY - SCIENCE J2 - J KING SAUD UNIV SCI VL - 34 PY - 2022 IS - 1 SN - 1018-3647 DO - 10.1016/j.jksus.2021.101675 UR - https://m2.mtmt.hu/api/publication/32694085 ID - 32694085 N1 - Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia Yousef Abdul Latif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia Department of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia Department of Surgery, School of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia Department of Medical Microbiology/Parasitology and Molecular Microbiology Laboratory, King Abdulaziz University Hospital, King Abdulaziz University, Saudi Arabia Laboratory of Molecular Cell Biology, Department of Zoology, Faculty of Science, Assiut University, Assiut, 71515, Egypt Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, 31511, Egypt Anatomy Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia Unidade Local de Saude de Castelo Branco, Castelo Branco, Portugal Family and Community Medicine Department, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia Department of Hematology/Pediatric Oncology, King Abdulaziz University Hospital, Faculty of Medicine, King Abdulaziz University, Saudi Arabia Albany Nutraceuticals, Rensselaer, NY 12144, United States Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, United States Export Date: 21 February 2022 Correspondence Address: Harkaeh, S.; Special Infectious Agents Unit, Saudi Arabia; email: sharakeh@gmail.com Funding details: King Abdulaziz University, KAU, 750-140-1441 Funding details: Deanship of Scientific Research, King Saud University Funding text 1: This project was funded by the Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah , under grant no. G: 750-140-1441 . The authors, therefore, acknowledge with thanks The DSR for their technical and financial support. AB - Objectives: Cisplatin (CISP) is an effective chemotherapy used in the treatment of various types of cancer, but it causes nephrotoxicity and other adverse effects. Thymoquinone (THY) is an effective anti-inflammatory and antioxidant compound, which might protects against many chemotherapies associated toxicities. However, THY applications are hindered by its poor solubility and low bioavailability. This study evaluated the efficacy of a novel nanoparticle (NP) encapsulting THY to overcome its poor solubility, enhance its bioavilability, efficacy for the protection against CISP-induced nephrotoxicity in an Ehrlich solid carcinoma (ESC) mice model. Methods: Four treatment groups were included: 1) control, 2) tumour, 3) CISP, and 4) CISP + NP THY. Results: The results showed that NP THY was effective in preventing CISP-induced kidney toxicity in ESC mice and improved its function and pathology. NP THY effectively ameliorated CISP-induced oxidative stress conditions in the kidney tissue via increasing the levels of antioxidants both non-enzymatic (GSH) and enzymatic (SOD and CAT). NP THY, also, significantly reduced CISP-induced kidney inflammation by reducing TNF-α, IL-1β, and NF-kB levels. NP THY didn't hinder the antitumor activity of CISP as shown by tumour weight and histological examination data. Conclusions: In conclusion, NP THY could be an adjuvant therapy to CISP cancer treatment to prevent associated nephrotoxicity and other adverse effects without compromising CISP antitumor efficacy. © 2021 The Author(s) LA - English DB - MTMT ER - TY - JOUR AU - Dandamudi, M. AU - McLoughlin, P. AU - Behl, G. AU - Rani, S. AU - Coffey, L. AU - Chauhan, A. AU - Kent, D. AU - Fitzhenry, L. TI - Chitosan-coated plga nanoparticles encapsulating triamcinolone acetonide as a potential candidate for sustained ocular drug delivery JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 13 PY - 2021 IS - 10 SN - 1999-4923 DO - 10.3390/pharmaceutics13101590 UR - https://m2.mtmt.hu/api/publication/32694088 ID - 32694088 N1 - Ocular Therapeutics Research Group, Pharmaceutical and Molecular Biotechnology Research Centre, Waterford Institute of Technology, Waterford, X91 K0EK, Ireland Department of Chemical and Biological Engineering, Colorado School of Mines, Colorado, CO 80401, United States The Vision Clinic, Kilkenny, R95 XC98, Ireland Cited By :2 Export Date: 21 February 2022 Correspondence Address: Dandamudi, M.; Ocular Therapeutics Research Group, Ireland; email: madhuri.dandamudi@postgrad.wit.ie Chemicals/CAS: chitosan, 9012-76-4; polyglactin, 26780-50-7, 34346-01-5; triamcinolone acetonide, 76-25-5 Manufacturers: Carbosynth, United Kingdom Funding details: Wentworth Institute of Technology, WIT, WD2017_PhD_023 Funding text 1: Funding: This research was funded by the WIT PhD scholarship (project code: WD2017_PhD_023). The APC was funded by Research Connexions, WIT. AB - The current treatment for the acquired retinal vasculopathies involves lifelong repeated intravitreal injections of either anti-vascular endothelial growth factor (VEGF) therapy or modulation of inflammation with steroids. Consequently, any treatment modification that decreases this treatment burden for patients and doctors alike would be a welcome intervention. To that end, this research aims to develop a topically applied nanoparticulate system encapsulating a corticosteroid for extended drug release. Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) supports the controlled release of the encapsulated drug, while surface modification of these NPs with chitosan might prolong the mucoadhesion ability leading to improved bioavailability of the drug. Triamcinolone acetonide (TA)-loaded chitosan-coated PLGA NPs were fabricated using the oil-in-water emulsion technique. The optimized surface-modified NPs obtained using Box-Behnken response surface statistical design were reproducible with a particle diameter of 334 ± 67.95 to 386 ± 15.14 nm and PDI between 0.09 and 0.15. These NPs encapsulated 55–57% of TA and displayed a controlled release of the drug reaching a plateau in 27 h. Fourier-transform infrared spectroscopic (FTIR) analysis demonstrated characteristic peaks for chitosan (C-H, CONH2 and C-O at 2935, 1631 and 1087 cm−1, respectively) in chitosan-coated PLGA NPs. This result data, coupled with positive zeta potential values (ranged between +26 and +33 mV), suggests the successful coating of chitosan onto PLGA NPs. Upon coating of the NPs, the thermal stability of the drug, polymer, surfactant and PLGA NPs have been enhanced. The characteristics of the surface-modified NPs supports their use as potential candidates for topical ocular drug delivery for acquired retinal vasculopathies. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. LA - English DB - MTMT ER - TY - JOUR AU - Jarrar, Hala AU - Altindal, Damla Cetin AU - Gumusderelioglu, Menemse TI - Scaffold-based osteogenic dual delivery system with melatonin and BMP-2 releasing PLGA microparticles JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 600 PY - 2021 PG - 10 SN - 0378-5173 DO - 10.1016/j.ijpharm.2021.120489 UR - https://m2.mtmt.hu/api/publication/32303384 ID - 32303384 N1 - Cited By :3 Export Date: 21 February 2022 CODEN: IJPHD Correspondence Address: Gümüşderelioğlu, M.; Hacettepe University, Bioengineering Department, Turkey; email: menemse@hacettepe.edu.tr Chemicals/CAS: chitosan, 9012-76-4; eosin, 17372-87-1, 51395-88-1, 548-26-5; hematoxylin, 517-28-2; hydroxyapatite, 1306-06-5, 51198-94-8; melatonin, 73-31-4; polyglactin, 26780-50-7, 34346-01-5; Bone Morphogenetic Protein 2; Glycols; Melatonin Funding details: Hacettepe Üniversitesi, FYL-2018-17242 Funding text 1: This study was supported by Hacettepe University Research Fund project no. FYL-2018-17242. AB - The growing safety problems about the use of bone morphogenetic protein 2 (BMP-2) is one of the recent issues that was improved by using low doses of BMP-2 with the support of other osteoinductive agents and/or using appropriate carriers. The aim of the present study is to investigate the effect of scaffold-based dual release system including melatonin (MEL) and BMP-2 loaded polylactic-co-glycolic acid (PLGA) microparticles on the osteogenic activity of pre-osteoblastic MC3T3-E1 cells. MEL and BMP-2 loaded microparticles were prepared by double emulsion solvent evaporation method in the average diameters of similar to 2 mu m and similar to 11 mu m, respectively and loaded into chitosan/hydroxyapatite (HAp) scaffolds. In vitro MC3T3-E1 culture studies were carried out comparatively with blank scaffolds, single (BMP-2 or MEL) releasing groups and dual (BMP-2 and MEL) releasing group. Microscopic observations and hematoxylin/eosin staining showed enhanced number of cells and dense ECM in dual release group. The expressions of differentiation markers, Runt-related transcription factor 2 (RUNX2) and alkaline phosphatase (ALP) and also mineralization were higher in dual release group than that of the other groups. Our findings showed that BMP-2 at low doses (similar to 20 ng per scaffold) was sufficient in terms of osteogenic activity with controlled release systems where it was used in combination with MEL (similar to 10 mu g per scaffold). LA - English DB - MTMT ER - TY - JOUR AU - Khaliq, Nisar Ul AU - Chobisa, Dhawal AU - Richard, Coralie A. AU - Swinney, Monica R. AU - Yeo, Yoon TI - Engineering microenvironment of biodegradable polyester systems for drug stability and release control JF - THERAPEUTIC DELIVERY J2 - THER DELIV VL - 12 PY - 2021 IS - 1 SP - 37 EP - 54 PG - 18 SN - 2041-5990 DO - 10.4155/tde-2020-0113 UR - https://m2.mtmt.hu/api/publication/32303385 ID - 32303385 N1 - Cited By :1 Export Date: 21 February 2022 Correspondence Address: Yeo, Y.; Department of Industrial and Physical Pharmacy, 575 Stadium Mall Drive, United States; email: yyeo@purdue.edu Chemicals/CAS: angiopeptin, 113294-82-9; bupivacaine, 18010-40-7, 2180-92-9, 55750-21-5, 38396-39-3, 73360-54-0, 27262-45-9; buprenorphine, 52485-79-7, 53152-21-9; chitosan, 9012-76-4; ciprofloxacin, 85721-33-1, 86393-32-0, 128074-72-6, 128074-76-0, 192934-52-4, 93107-08-5, 86483-48-9, 96186-80-0; cyclodextrin, 12619-70-4; dexamethasone, 50-02-2; dextran, 87915-38-6, 9014-78-2; doxycycline, 10592-13-9, 17086-28-1, 564-25-0, 94088-85-4; doxycycline hyclate, 24390-14-5; everolimus, 159351-69-6; exendin 4, 141732-76-5, 141758-74-9; goserelin, 65807-02-5; human growth hormone, 12629-01-5; insulin, 9004-10-8; latanoprost, 130209-82-4; leuprorelin, 53714-56-0, 74381-53-6; lysozyme, 9001-63-2; macrogol, 25322-68-3; minocycline, 10118-90-8, 11006-27-2, 13614-98-7; mometasone furoate, 83919-23-7, 105102-22-5; naltrexone, 16590-41-3, 16676-29-2; octreotide, 83150-76-9, 1607842-55-6, 135467-16-2, 79517-01-4; pasireotide, 396091-73-9; poloxamer, 9003-11-6; polycaprolactone, 24980-41-4, 25248-42-4; polydioxanone, 31621-87-1; polyglactin, 26780-50-7, 34346-01-5; polylactic acid, 26100-51-6; polylactide, 26680-10-4; polyvinyl alcohol, 37380-95-3, 9002-89-5; povidone, 9003-39-8; progesterone, 57-83-0; rapamycin, 53123-88-9; recombinant bone morphogenetic protein 2, 246539-15-1; risperidone, 106266-06-2; shellac, 9000-59-3; sucrose, 122880-25-5, 57-50-1; tetanus toxoid, 57425-69-1, 93384-51-1; tetracycline, 23843-90-5, 60-54-8, 64-75-5, 8021-86-1; trehalose, 99-20-7, 6138-23-4; triamcinolone, 124-94-7; triamcinolone acetonide, 76-25-5; triptorelin, 57773-63-4, 140194-24-7; lactic acid, 113-21-3, 50-21-5; polyglycolic acid, 26009-03-0, 26124-68-5, 26202-08-4; Lactic Acid; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer Tradenames: arestin, OraPharma; atridox, Collagenex; atridox, Atrix; bydureon, Astra Zeneca; bydureon bcise, Astra Zeneca; eligard, Tolmar; lupaneta pack, AbbVie; lupron depot, AbbVie; nutropin depot, Genentech; ozurdex, Allergan; perseris, Indivior; propel, Intersect ENT; risperdal consta, Janssen; sandostatin lar, Novartis; signifor, Novartis; somatuline depot, Ipsen; sublocade, Indivior; trelstar, Allergen; triptodur kit, Arbor; vivitrol, Alkermes; zilretta, Flexion; zoladex, Astra Zeneca Manufacturers: AbbVie; Alkermes; Allergan; Allergen; Arbor; Astra Zeneca; Atrix; Collagenex; Flexion; Genentech; Indivior; Intersect ENT; Ipsen; Janssen; Novartis; OraPharma; Tolmar Funding details: Eli Lilly and Company Funding text 1: This research was supported by Eli Lilly and Company. The authors also acknowledge support for Dhawal Chobisa under the Dr Reddy’s Lab – Purdue Doctoral Fellowship Program. The authors have no other financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. AB - Polymeric systems made of poly(lactic acid) or poly(lactic-co-glycolic acid) are widely used for long-term delivery of small and large molecules. The advantages of poly(lactic acid)/poly(lactic-co-glycolic acid) systems include biodegradability, safety and a long history of use in US FDA-approved products. However, as drugs delivered by the polymeric systems and their applications become more diverse, the significance of microenvironment change of degrading systems on long-term drug stability and release kinetics has gained renewed attention. In this review, we discuss various issues experienced with acidifying microenvironment of biodegradable polymer systems and approaches to overcome the detrimental effects of polymer degradation on drug stability and release control. LA - English DB - MTMT ER - TY - JOUR AU - Motawea, Amira AU - Ahmed, Dalia Alsaied Moustafa AU - El-Mansy, Ahmed A. AU - Saleh, Noha Mohamed TI - Crucial Role of PLGA Nanoparticles in Mitigating the Amiodarone-Induced Pulmonary Toxicity JF - INTERNATIONAL JOURNAL OF NANOMEDICINE J2 - INT J NANOMED VL - 16 PY - 2021 SP - 4713 EP - 4737 PG - 25 SN - 1176-9114 DO - 10.2147/IJN.S314074 UR - https://m2.mtmt.hu/api/publication/32303383 ID - 32303383 N1 - Export Date: 21 February 2022 Correspondence Address: Saleh, N.M.; Pharmaceutics Department, Egypt; email: nunu_ramy@mans.edu.eg Chemicals/CAS: amiodarone, 1951-25-3, 19774-82-4, 62067-87-2; polyglactin, 26780-50-7, 34346-01-5; Amiodarone; Drug Carriers; Polylactic Acid-Polyglycolic Acid Copolymer Manufacturers: Global Napi, Egypt AB - Background: Amiodarone (AMD) is a widely used anti-arrhythmic drug, but its administration could be associated with varying degrees of pulmonary toxicity. In attempting to circumvent this issue, AMD-loaded polymeric nanoparticles (AMD-loaded NPs) had been designed.Materials and Methods: AMD was loaded in NPs by the nanoprecipitation method using two stabilizers: bovine serum albumin and Kolliphor (R) P 188. The physicochemical properties of the AMD-loaded NPs were determined. Among the prepared NPs, two ones were selected for further investigation of spectral and thermal analysis as well as morphological properties. Additionally, in vitro release patterns were studied and kinetically analyzed at different pH values. In vitro cytotoxicity of an optimized formula (NP4) was quantified using A549 and Hep-2 cell lines. In vivo assessment of the pulmonary toxicity on Sprague Dawley rats via histopathological and immunohistochemical evaluations was applied.Results: The developed NPs achieved a size not more than 190 nm with an encapsulation efficiency of more than 88%. Satisfactory values of loading capacity and yield were also attained. The spectral and thermal analysis demonstrated homogeneous entrapment of AMD inside the polymeric matrix of NPs. Morphology revealed uniform, core-shell structured, and sphere-shaped particles with a smooth surface. Furthermore, the AMD-loaded NPs exhibited a pH-dependent and diffusion-controlled release over a significant period without an initial burst effect. NP4 demonstrated a superior cytoprotective efficiency by diminishing cell death and significantly increasing the IC50 by more than threefold above the pure AMD. Also, NP4 ameliorated AMD-induced pulmonary damage in rats. Significant downregulation of inflammatory mediators and free radicle production were noticed in the NP4-treated rats.Conclusion: The AMD-loaded NPs could ameliorate the pulmonary injury induced by the pure drug moieties. Cytoprotective, anti-fibrotic, anti-inflammatory, and antioxidant properties were presented by the optimized NPs (NP4). Future studies may be built on these findings for diminishing AMD-induced off-target toxicities. LA - English DB - MTMT ER - TY - JOUR AU - Yuan, C. AU - Long, X. AU - Li, J. AU - Cai, Q. TI - Coaxially electrospun 5-fluorouracil-loaded PLGA/PVP fibrous membrane for skin tumor treatment JF - BIOMEDICAL MATERIALS J2 - BIOMED MATER VL - 16 PY - 2021 IS - 6 SN - 1748-6041 DO - 10.1088/1748-605X/ac2887 UR - https://m2.mtmt.hu/api/publication/32694086 ID - 32694086 N1 - State Key Laboratory of Organic-Inorganic Composites, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China Department of Oncology, Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, 100029, China Export Date: 21 February 2022 Correspondence Address: Li, J.; Department of Oncology, China; email: lijinghua1014@sina.com Chemicals/CAS: fluorouracil, 51-21-8; polyglactin, 26780-50-7, 34346-01-5; povidone, 9003-39-8 AB - As a biocompatible and biodegradable polymer, poly(lactide-co-glycolide) (PLGA) has been widely used as a carrier to achieve controlled drug delivery in various forms. Focusing on skin tumor treatment, herein 5-fluorouracil (5-FU) was embedded into the core of coaxially electrospun PLGA fibers to get a drug-loaded core-shell fibrous membrane. In the coaxial electrospinning, poly(vinylpyrrolidone) was applied in the inner flow to facilitate the formation of the core-shell structured fibers. The morphology and micro-structure of the fibers were characterized by scanning electron microscope and transmission electron microscope. The influences of the molecular weights and chemical compositions of PLGA copolymers on the release behaviors were studied. The cytotoxicity of the fibers was characterized by cell proliferation and living-dead cell staining experiments. The results showed that faster release rates would be obtained if the copolymers were of lower molecular weights and higher fraction of glycidyl unit. All the prepared 5-FU loaded fibrous membranes were non-cytotoxic, suggesting their potential applications in skin tumor treatment. © 2021 IOP Publishing Ltd. LA - English DB - MTMT ER - TY - JOUR AU - Arisoy, Sema AU - Sayiner, Ozgun AU - Comoglu, Tansel AU - Onal, Deniz AU - Atalay, Ozbeyen AU - Pehlivanoglu, Bilge TI - In vitro and in vivo evaluation of levodopa-loaded nanoparticles for nose to brain delivery JF - PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY J2 - PHARM DEV TECHNOL VL - 25 PY - 2020 IS - 6 SP - 735 EP - 747 PG - 13 SN - 1083-7450 DO - 10.1080/10837450.2020.1740257 UR - https://m2.mtmt.hu/api/publication/31419834 ID - 31419834 N1 - Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara University, Ankara, Turkey Faculty of Pharmacy, Department of Pharmaceutical Biotechnology, Inonu University, Malatya, Turkey Faculty of Medicine, Department of Physiology, Hacettepe University, Ankara, Turkey Cited By :16 Export Date: 21 February 2022 CODEN: PDTEF Correspondence Address: Comoglu, T.; Faculty of Pharmacy, Turkey; email: comoglu@pharmacy.ankara.edu.tr Chemicals/CAS: cyanamide, 151-51-9, 420-04-2; levodopa, 59-92-7; polyglactin, 26780-50-7, 34346-01-5; Antiparkinson Agents; Levodopa Funding details: 116S639 Funding details: Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK Funding text 1: This study is granted by The Scientific and Technological Research Council of Turkey (TUBITAK) with the project no: 116S639. AB - Parkinson's disease (PD) is a neurodegenerative disease which is characterized by the loss of dopaminergic neurons in the brain. Levodopa is the drug of choice in the treatment of PD but it exhibits low oral bioavailability (30%) and very low brain uptake due to its extensive metabolism by aromatic amino acid decarboxylase in the peripheral circulation. Moreover, levodopa has psychic, gastrointestinal, and cardiovascular side effects, and most importantly, short and frequent stimulation of dopamine receptors lead to undesirable conditions such as dyskinesia over time. The challenges are to increase the therapeutic efficiency, the bioavailability and decreasing the unfavourable side effects of levodopa. Biocompatible nano-sized drug carriers could address these challenges at molecular level. For this purpose, levodopa-loaded Poly (lactide-co-glycolide) acid nanoparticles were prepared by double emulsion-solvent evaporation method for nose to brain drug delivery. Parameters such as homogenization speed, and external and internal phase content were modified to reach the highest loading efficiency. F1-1 coded formulation showed prolonged release up to 9 h. Carbodiimide method was used for surface modification studies of nanoparticles. The efficacy of the selected nanoparticle formulation has been demonstrated by in vivo experiments in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced PD model in mice. LA - English DB - MTMT ER - TY - JOUR AU - Esim, O. AU - Bakirhan, N.K. AU - Sarper, M. AU - Savaser, A. AU - Ozkan, S.A. AU - Ozkan, Y. TI - Influence of emulsifiers on the formation and in vitro anticancer activity of epirubicin loaded PLGA nanoparticles JF - JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY J2 - J DRUG DELIV SCI TEC VL - 60 PY - 2020 SN - 1773-2247 DO - 10.1016/j.jddst.2020.102027 UR - https://m2.mtmt.hu/api/publication/32694091 ID - 32694091 N1 - University of Health Sciences, Gulhane Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Turkey University of Health Sciences, Gulhane Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, Turkey University of Health Sciences, Gulhane Institute of Health Sciences, Stem Cell Research Center, Ankara, Turkey University of Ankara, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, 06100, Turkey Cited By :4 Export Date: 21 February 2022 CODEN: JDDSA Correspondence Address: Esim, O.; University of Health Sciences, Turkey; email: ozgur.esim@sbu.edu.tr Chemicals/CAS: cholic acid, 32500-01-9, 361-09-1, 81-25-4; epirubicin, 56390-09-1, 56420-45-2; polyglactin, 26780-50-7, 34346-01-5 AB - Surfactants play an important role in preparation of nanoparticles. In this study, it was aimed to investigate the effect of surfactant type and concentration on development of epirubicin loaded Poly (D,L-lactide-coglycolide acid) (PLGA) nanoparticles. In this regard PVA, TPGS, sodium cholate and Poloxamer 188 were used as surfactants to prepare epirubicin loaded PLGA nanoparticles in three concentrations. It was found that the particle size of nanoparticles was varied in the range 109.6 ± 5.19 nm and 511.5 ± 23.99 nm. The size of nanoparticles was smaller when sodium cholate was used (p < 0.05). It was observed that encapsulation efficiency of nanoparticles was higher for those emulsified by sodium cholate at low concentrations (0.3%) (p < 0.05). Lower IC50 doses were found lower at 24 h when nanoparticles fabricated by sodium cholate (4.71 ± 0.67 μg/mL, 17.96 ± 1.25 μg/mL and 27.78 ± 1.44 μg/mL for 0.3%, 1% and 2%) compared with drug solution (218.00 ± 20.33 μg/mL) in human lung squamous cell carcinoma (SK-MES-1) cells (p < 0.05). Both qualitative fluorescent images and quantitative results showed that nanoparticles prepared with sodium cholate demonstrated greater cellular uptake of nanoparticles. Thus, sodium cholate could be useful in developing epirubicin loaded PLGA nanoparticles for non-small cell lung cancer treatment. © 2020 Elsevier B.V. LA - English DB - MTMT ER - TY - JOUR AU - Grizic, Daris AU - Lamprecht, Alf TI - Process parameters of microsphere preparation based on propylene carbonate emulsion-precursors JF - JOURNAL OF MICROENCAPSULATION J2 - J MICROENCAPSUL PY - 2020 PG - 10 SN - 0265-2048 DO - 10.1080/02652048.2020.1823501 UR - https://m2.mtmt.hu/api/publication/31692924 ID - 31692924 N1 - Cited By :1 Export Date: 21 February 2022 CODEN: JOMIE Correspondence Address: Lamprecht, A.; Department of Pharmaceutics, Gerhard-Domagk-Str. 3, Germany Chemicals/CAS: celecoxib, 169590-42-5; polyglactin, 26780-50-7, 34346-01-5; propylene carbonate, 108-32-7; lactic acid, 113-21-3, 50-21-5; polyglycolic acid, 26009-03-0, 26124-68-5, 26202-08-4; polypropylene, 25085-53-4, 9003-07-0; Celecoxib; Drug Carriers; Emulsions; Lactic Acid; Polyglycolic Acid; Polymers; polypropylene carbonate; Polypropylenes; Solvents Tradenames: DSC2, Mettler Toledo, Afghanistan; Helos; LiChrospher 100 RP-18; PANalytical X'Pert HighScore Plus version 2.2.c; Roto Visco 1, Thermo, Germany; STAReSW 13.0; X'Pert Manufacturers: Sigma Aldrich, Germany; TCI, GermanyMettler Toledo, Afghanistan; Thermo, Germany Funding details: Deutscher Akademischer Austauschdienst, DAAD, 91540177, A/13/91141 Funding details: Agence Nationale de la Recherche, ANR, ANR-11-LABX-0021 Funding text 1: Daris Grizic would like to acknowledge the German Academic Exchange Service (DAAD) for the financial support (91540177; A/13/91141). Funding text 2: This work was partially supported by a French Government grant managed by the French National Research Agency under the program ?Investissements d?Avenir? with reference ANR-11-LABX-0021. Daris Grizic would like to acknowledge the German Academic Exchange Service (DAAD) for the financial support (91540177; A/13/91141). AB - AimThis study aimed for a detailed understanding of the impact of different process parameters involved during celecoxib-loaded microsphere preparation based on propylene carbonate emulsion-precursors.MethodsMicrospheres were prepared by a modified emulsification-solvent extraction method. Performed investigations included polymer solubility and viscosity, microsphere size, morphology and stability, propylene carbonate content as well as celecoxib solid state, content and release.ResultsRough-walled round microspheres with sizes between 21 mu m and 122 mu m and an internal sponge-like structure filled with residual propylene carbonate (content between 1.9 +/- 0.1% and 6.7 +/- 0.5% w/w) were obtained. Encapsulation efficiencies varied between 28.3 +/- 0.1% and 66.8 +/- 1.0%. The release rates were affected by the polymer concentration, the emulsion phase ratio and the residual propylene carbonate content (t(50%) varied between 2.2 hours and 23.4 hours).ConclusionsThis study identified the most relevant process parameters for this new preparation method for the model drug celecoxib. LA - English DB - MTMT ER - TY - JOUR AU - Hajba-Horváth, Eszter AU - Biró, Emese AU - Mirankó, Mirella AU - Fodorné Kardos, Andrea AU - Trif, László AU - Feczkó, Tivadar TI - Preparation and in vitro characterization of valsartan-loaded ethyl cellulose and poly(methyl methacrylate) nanoparticles JF - RSC ADVANCES J2 - RSC ADV VL - 10 PY - 2020 IS - 72 SP - 43915 EP - 43926 PG - 12 SN - 2046-2069 DO - 10.1039/D0RA07218D UR - https://m2.mtmt.hu/api/publication/31744086 ID - 31744086 N1 - Research Institute of Biomolecular and Chemical Engineering, Faculty of Engineering, University of Pannonia, Egyetem u. 10, Veszprém, H-8200, Hungary Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences Magyar, Tudósok Körútja 2, Budapest, H-1117, Hungary Cited By :3 Export Date: 21 February 2022 CODEN: RSCAC Funding details: GINOP-2.3.3-15-2016-0009 Funding details: Magyarország Kormánya Funding text 1: Authors would like to acknowledge the National Competitiveness and Excellence Program, Hungary for providing funding in frame of GINOP-2.2.1-15-2016-00023 and the TKP2020-IKA-07 project nanced under the 2020-4.1.1-TKP2020 Thematic Excellence Programme by the National Research, Development and Innovation Fund of Hungary. S/TEM studies were performed at the electron microscopy laboratory of the University of Pannonia, established using grant no. GINOP-2.3.3-15-2016-0009 from the European Structural and Investments Funds and the Hungarian Government. The authors are especially grateful to the EGIS Pharmaceuticals PLC for their partnership and they thank Péter Pekker and Miklós Jakab for the TEM/SEM imaging of the nanoparticles and Éva Kristóf-Makó for the X-ray powder diffraction analysis. LA - English DB - MTMT ER - TY - JOUR AU - Hashemi, Fatemeh Sadat AU - Farzadnia, Farin AU - Aghajani, Abdoreza AU - NobariAzar, Farnaz Ahmadzadeh AU - Pezeshki, Akram TI - Conjugated linoleic acid loaded nanostructured lipid carrier as a potential antioxidant nanocarrier for food applications JF - FOOD SCIENCE AND NUTRITON J2 - FOOD SCI NUTR PY - 2020 PG - 11 SN - 2048-7177 DO - 10.1002/fsn3.1712 UR - https://m2.mtmt.hu/api/publication/31419836 ID - 31419836 N1 - Department of Food Science and Technology, Elmi-karbordi University of Samin Nan Sahar, Tehran, Iran Department of Food Science and Technology, Faculty of Agriculture, Mamaghan Branch, Islamic Azad University of Mamaghan, Mamaghan, Iran Department of Food Science and Technology, Faculty of Industrial and Mechanical Engineering, Qazvin Branch, Islamic Azad University, Qazvin, Iran Department of Food Science and Technology, Faculty of Agriculture, University of Tabriz, Tabriz, Iran Cited By :13 Export Date: 21 February 2022 Correspondence Address: Pezeshki, A.; Department of Food Science and Technology, Iran; email: Akram.pezeshki@tabrizu.ac.ir AB - The encapsulation of fatty acids in nanocarrier systems is a very effective technique in improving their biological efficiency and controlled delivery. Nanostructured lipid carrier (NLC) is a major type of lipid-based nanoparticle. This study is focused on producing nanolipid carrier containing conjugated linoleic acid and fortifying low-fat milk using this nanoparticle. Nanostructured lipid carriers were produced by hot high-shear homogenization containing 1.5% Poloxamer 407, cocoa butter as solid lipid, and conjugated linoleic acid as liquid oil in ratio of 10:1. Results showed that the nanoparticles sized 81 nm with monomodular dispersity and the system was stable at 4 and 22 degrees C for 40 days. Zeta potential and encapsulation efficiency (%EE) were -15.8 mV and 98.2%, respectively. Scanning electron microscopy (SEM) showed that the particles are in spiral form and small size and no significant aggregation was observed because of few changes in the system turbidity after storage time. The result of oxidative stability showed that using Nanostructured lipid carriers system resulted in lower malone dialdehyde production. Conjugated linoleic acid was protected at level of 3.9% of milk fatty acids in Nanostructured lipid carrier formulation during storage time. Based on these findings, Nanostructured lipid carriers system is an appropriate and stable nanocarrier system for delivery of nutraceuticals in foods and can be used in protecting them against oxidation, heating, and other processes in order to fortify foods and beverages. LA - English DB - MTMT ER - TY - JOUR AU - Otte, A. AU - Sharifi, F. AU - Park, K. TI - Interfacial tension effects on the properties of PLGA microparticles JF - COLLOIDS AND SURFACES B: BIOINTERFACES J2 - COLLOID SURFACE B VL - 196 PY - 2020 SN - 0927-7765 DO - 10.1016/j.colsurfb.2020.111300 UR - https://m2.mtmt.hu/api/publication/32694089 ID - 32694089 N1 - Purdue University, Weldon School of Biomedical Engineering, West Lafayette, IN 47907, United States Purdue University, Department of Pharmaceutics, West Lafayette, IN 47907, United States Cited By :4 Export Date: 21 February 2022 CODEN: CSBBE Correspondence Address: Otte, A.; Purdue University, United States; email: aotte@purdue.edu Chemicals/CAS: polyglactin, 26780-50-7, 34346-01-5; lactic acid, 113-21-3, 50-21-5; polyglycolic acid, 26009-03-0, 26124-68-5, 26202-08-4; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer Funding details: National Institute on Drug Abuse, NIDA, UG3DA048774 Funding details: Ralph W. and Grace M. Showalter Research Trust Fund Funding text 1: This study was supported by Grant UG3 DA048774 from the National Institute of Drug Abuse and the Showalter Research Trust Fund. Funding text 2: This study was supported by Grant UG3 DA048774 from the National Institute of Drug Abuse and the Showalter Research Trust Fund . AB - Many types of long-acting injectables, including in situ forming implants, preformed implants, and polymeric microparticles, have been developed and ultimately benefited numerous patients. The advantages of using long-acting injectables include greater patient compliance and more steady state drug plasma levels for weeks and months. However, the development of long-acting polymeric microparticles has been hampered by the lack of understanding of the microparticle formation process, and thus, control of the process. Of the many parameters critical to the reproducible preparation of microparticles, the interfacial tension (IFT) effect is an important factor throughout the process. It may influence the droplet formation, solvent extraction, and drug distribution in the polymer matrix, and ultimately drug release kinetics from the microparticles. This mini-review is focused on the IFT effects on drug-loaded poly(lactic-co-glycolic acid) (PLGA) microparticles. © 2020 Elsevier B.V. LA - English DB - MTMT ER - TY - JOUR AU - Shahbaz, Sanaz Keshavarz AU - Varasteh, Abdol-Reza AU - Koushki, Khadijeh AU - Ayati, Seyed Hasan AU - Mashayekhi, Kazem AU - Sadeghi, Mahvash AU - Moghadam, Malihe AU - Sankian, Mojtaba TI - Sublingual dendritic cells targeting by aptamer: Possible approach for improvement of sublingual immunotherapy efficacy JF - INTERNATIONAL IMMUNOPHARMACOLOGY J2 - INT IMMUNOPHARMACOL VL - 85 PY - 2020 PG - 14 SN - 1567-5769 DO - 10.1016/j.intimp.2020.106603 UR - https://m2.mtmt.hu/api/publication/31419832 ID - 31419832 N1 - Immunology Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran Allergy Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran Cited By :5 Export Date: 21 February 2022 CODEN: IINMB Correspondence Address: Sankian, M.; Immunology Research Center, Iran; email: Sankianm@mums.ac.ir Chemicals/CAS: gamma interferon, 82115-62-6; ovalbumin, 77466-29-6; polyglactin, 26780-50-7, 34346-01-5; Allergens; Aptamers, Nucleotide; Ovalbumin; Polylactic Acid-Polyglycolic Acid Copolymer Manufacturers: mebep bioscience, China Funding details: Mashhad University of Medical Sciences, MUMS, 941467 Funding text 1: This work was supported by the deputy of research at Mashhad University of medical sciences, Mashhad, Iran, under Grant No (941467). AB - The efficacy improvement of current sublingual immunotherapy (SLIT) for preventing and treating respiratory airway allergic diseases is the main purpose of many investigations. In this study, we aimed to assess whether ovalbumin (Ova) encapsulated poly (lactic-co-glycolic) acid nanoparticles (PLGA NPs) decorated with dendritic cells (DCs)-specific aptamer could be applied for this purpose. The nanoparticles containing Ova were synthesized by emulsion/solvent evaporation method and attached to DCs-specific aptamer. Ova-sensitized BALB/c mice have been treated in five ways: subcutaneously with free Ova (SCIT), sublingually either with free Ova, Ova-PLGA NPs (two doses), Apt-Ova-PLGA NPs (two doses) and placebo/control Apt-Ova-PLGA NPs. For assessment of immunologic responses, IL-4, IFN-gamma, IL-17, IL10, and TGF-beta and IgE antibody levels were measured by ELISA and T cell proliferation were evaluated by MTT. In addition, lung and nasal histological examinations, NALF cells counting were carried out. Results declared that the lowest IgE and IL-4 levels were observed in Apt-Ova-PLGA NPs (both doses). In the other hands, Apt-Ova-PLGA NPs (high dose) showed the highest increase of IFN-gamma and TGF-beta, decrease of IL-17 levels, total cell count and T-cell proliferation. IL-10 levels showed more decrease in SCIT, Apt-Ova-PLGA NPs (high dose) and Ova-PLGA NPs (high dose) than other groups. Histopathological examinations also confirmed in vitro results. Our findings suggest SLIT with this functionalized delivery system could be a promising approach for promoting the SLIT efficiency by decreasing the required allergen doses through specific delivery of allergen to sublingual DCs and enhancing the suppression of allergic responses. LA - English DB - MTMT ER - TY - JOUR AU - Chen Xiao-ting, null AU - Wang, Tongxin TI - Preparation and characterization of atrazine-loaded biodegradable PLGA nanospheres JF - JOURNAL OF INTEGRATIVE AGRICULTURE J2 - J INTEGR AGRIC VL - 18 PY - 2019 IS - 5 SP - 1035 EP - 1041 PG - 7 SN - 2095-3119 DO - 10.1016/S2095-3119(19)62613-4 UR - https://m2.mtmt.hu/api/publication/30963270 ID - 30963270 N1 - College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops/Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fuzhou, 350002, China CREST Center for Nanomaterials, College of Engineering, Howard University, Washington, DC 20059, United States College of Dentistry, Howard University, Washington, DC 20059, United States Cited By :10 Export Date: 21 February 2022 Correspondence Address: CHEN, X.-T.; College of Life Sciences, China; email: xiaotingchen@fafu.edu.cn Funding details: 2012J01079 Funding details: National Natural Science Foundation of China, NSFC, 30671347 Funding text 1: The authors thank the financial supports of the National AB - Atrazine is the second mostly used herbicide in USA, but low utilization ratio causes severe environmental problem, so controlled release system is highly needed in order to minimize the negative impact on environment. In this paper, a herbicide delivery system, atrazine-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were prepared by forming an oil-in-water emulsion using the emulsion-solvent evaporation method. By varying the preparation conditions of PLGA-NPs, such as sonication time, surfactant content, solvent fraction, and polymer content, the particle sizes of the PLGA-NPs were well controlled from 204 to 520 nm. The morphology and size distribution of PLGA-NPs were evaluated using dynamic light scattering (DLS) and scanning electron microscopy (SEM). Both the encapsulation efficiency and release profile of the herbicide from the PLGA-NPs were typically evaluated by using 2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine (atrazine, ATZ) as the model. ATZ encapsulation efficiency within the PLGA-NPs was ranged from 31.6 to 50.5%. The release profiles of ATZ-loaded PLGA-NPs exhibited a much slower release rate in comparison with that of pure herbicide. The results demonstrated that the prepared PLGA-NPs had a high encapsulation efficiency and slow release rate, which could be used as a promising herbicide release system in agriculture to diminish the impact on the environment and minimize the potential harm to the farmers. LA - English DB - MTMT ER - TY - JOUR AU - Hajavi, Jafar AU - Hashemi, Maryam AU - Sankian, Mojtaba TI - Evaluation of size and dose effects of rChe a 3 allergen loaded PLGA nanoparticles on modulation of Th2 immune responses by sublingual immunotherapy in mouse model of rhinitis allergic JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 563 PY - 2019 SP - 282 EP - 292 PG - 11 SN - 0378-5173 DO - 10.1016/j.ijpharm.2019.03.040 UR - https://m2.mtmt.hu/api/publication/31019666 ID - 31019666 N1 - Cited By :10 Export Date: 21 February 2022 CODEN: IJPHD Correspondence Address: Sankian, M.; Immunology Research Center, Iran; email: sankianm@mums.ac.ir Chemicals/CAS: gamma interferon, 82115-62-6; interleukin 2, 85898-30-2; Allergens; Drug Carriers; Polylactic Acid-Polyglycolic Acid Copolymer Funding details: Mashhad University of Medical Sciences, MUMS, 930731 Funding text 1: This work was supported by the deputy of research at Mashhad University of medical sciences, Mashhad, Iran, under Grant No. 930731 . LA - English DB - MTMT ER - TY - JOUR AU - Karp, F. AU - Busatto, C. AU - Turino, L. AU - Luna, J. AU - Estenoz, D. TI - PLGA nano- and microparticles for the controlled release of florfenicol: Experimental and theoretical study JF - JOURNAL OF APPLIED POLYMER SCIENCE J2 - J APPL POLYM SCI VL - 136 PY - 2019 IS - 12 PG - 10 SN - 0021-8995 DO - 10.1002/app.47248 UR - https://m2.mtmt.hu/api/publication/30448497 ID - 30448497 N1 - Cited By :5 Export Date: 21 February 2022 CODEN: JAPNA Correspondence Address: Estenoz, D.; Instituto de Desarrollo Tecnológico para la Industria Química, Güemes 3450, Argentina; email: destenoz@santafe-conicet.gov.ar Funding details: Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET Funding details: Agencia Nacional de Promoción Científica y Tecnológica, ANPCyT Funding details: Universidad Nacional del Litoral, UNL Funding text 1: The authors wish to express their gratitude to Agencia Nacional de Promoción Científica y Tecnológica (ANPCYT), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), and Universidad Nacional del Litoral (UNL) of Argentina, for the financial support granted to this contribution. Funding text 2: The authors wish to express their gratitude to Agencia Nacional de Promoci?n Cient?fica y Tecnol?gica (ANPCYT), Consejo Nacional de Investigaciones Cient?ficas y T?cnicas (CONICET), and Universidad Nacional del Litoral (UNL) of Argentina, for the financial support granted to this contribution. AB - In this study, PLGA particle systems were studied for the controlled release of florfenicol, a broad spectrum antibiotic used in veterinary treatments. The emulsion-solvent evaporation technique was used for particle preparation. To evaluate the particle size, entrapment efficiency, and drug release behavior, factors such as solvent type, emulsification time and methods, and drug to polymer ratio were investigated. The results showed that the use of ethyl acetate and 2.5 min of ultrasonication or 30 min of homogenization can lead to sub-micron and micron-sized particles, respectively. Sizes between 200-300 nm and 2-3 mu m were obtained for ultrasonication and homogenization procedures, respectively. Entrapment efficiencies were around 20% for all systems and release profiles were size dependent. In addition, a mathematical model was implemented to simulate the florfenicol transport. The model predicts the florfenicol release and takes into account the particle size, polymer molecular weight, and autocatalytic polymer degradation. Simulation results are in good agreement with experimental results. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47248. LA - English DB - MTMT ER - TY - JOUR AU - Lu, Wei AU - Meng, Qingwei AU - Qin, Chuanrui AU - Li, Jinliang AU - Qi, Guansheng AU - Kong, Biao AU - He, Zhenglong TI - Facile and efficient isocyanate microencapsulation via SDBS/PVP synergetic emulsion JF - JOURNAL OF APPLIED POLYMER SCIENCE J2 - J APPL POLYM SCI VL - 136 PY - 2019 IS - 41 PG - 8 SN - 0021-8995 DO - 10.1002/app.48045 UR - https://m2.mtmt.hu/api/publication/31019665 ID - 31019665 N1 - State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao, 266590, China College of Mining and Safety Engineering, Shandong University of Science and Technology, Qingdao, 266590, China National Demonstration Center for Experimental Mining Engineering Education, Shandong University of Science and Technology, Qingdao, 266590, China State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China Cited By :4 Export Date: 21 February 2022 CODEN: JAPNA Correspondence Address: He, Z.; State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and Ministry of Science and Technology, China; email: hzl_safety@sdust.edu.cn Funding details: 2018YFC0807900, 2018YFC0807906 Funding details: SKLCRSM18KF013 Funding details: Department of Science and Technology of Shandong Province Funding details: National Natural Science Foundation of China, NSFC, 51574279, 51804185 Funding details: Chinese Academy of Sciences, CAS Funding details: Dalian Institute of Chemical Physics, DICP Funding details: Shandong University of Science and Technology, SDUST Funding details: China University of Mining and Technology, CUMT, KJZH2017K07 Funding details: Natural Science Foundation of Shandong Province, ZR2018BEE003 Funding details: State Key Laboratory of Coal Resources and Safe Mining Funding text 1: 1State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao 266590, China 2College of Mining and Safety Engineering, Shandong University of Science and Technology, Qingdao 266590, China 3National Demonstration Center for Experimental Mining Engineering Education, Shandong University of Science and Technology, Qingdao 266590, China 4State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China Correspondence to: Z. He (E-mail: hzl_safety@sdust.edu.cn) Funding text 2: The authors gratefully acknowledge financial support from the National Key R&D Program of China (No. 2018YFC0807900, 2018YFC0807906), the National Natural Science Foundation of China (No. 51574279, 51804185), the Natural Science Foundation of Shandong Province (ZR2018BEE003), the Open Project Funding (SKLCRSM18KF013) of the State Key Laboratory of Coal Resources and Safe Mining (China University of Mining & Technology), and the Open Project Funding (KJZH2017K07) of Key Laboratory of Mine Disaster Prevention, North China Institute of Science and Technology. AB - A binary emulsion system via combination of sodium dodecylbenzenesulfonate (SDBS) and polyvinyl pyrrolidone (PVP) was employed to prepare microcapsules containing isophorone diisocyanate. The effect of different concentrations of SDBS and PVP on the size and distribution of capsules was investigated. The results showed that uniform and size-controllable capsules were synthesized by synergistic function of SDBS and PVP. Characteristics of capsule were studied by optical microscopy, Fourier transform infrared spectrometry, scanning electron microscopy, thermal gravimetric analysis, and H-1 NMR. The results revealed that the core content and yield of the spherical capsules were approximately 65.7 and 79 wt %, respectively, at the capsule diameter of similar to 115 mu m. The residue core content of microcapsules was approximately 44.7 wt % after immersion in water for 10 days. And its self-healing epoxy coatings showed excellent corrosion resistance performance after accelerated corrosion tests. These results exhibited the feasibility and great application prospect of the multiemulsifiers system in the microcapsule synthesis process. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48045. LA - English DB - MTMT ER - TY - JOUR AU - Urbaniak, Tomasz AU - Musial, Witold TI - Influence of Solvent Evaporation Technique Parameters on Diameter of Submicron Lamivudine-Poly-epsilon-Caprolactone Conjugate Particles JF - NANOMATERIALS J2 - NANOMATERIALS-BASEL VL - 9 PY - 2019 IS - 9 PG - 18 SN - 2079-4991 DO - 10.3390/nano9091240 UR - https://m2.mtmt.hu/api/publication/31019664 ID - 31019664 N1 - Cited By :11 Export Date: 21 February 2022 Correspondence Address: Musiał, W.; Department of Physical Chemistry and Biophysics, Borowska 211, Poland; email: witold.musial@umed.wroc.pl Funding details: Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu, STM.D060.16.032 Funding text 1: This research was funded by Wroclaw Medical University Young Scientist Project grant number STM.D060.16.032. Funding text 2: Funding: This research was funded by Wroclaw Medical University Young Scientist Project grant number STM.D060.16.032. AB - The size of active pharmaceutical ingredient carrier is one of the key properties considered during design of submicron drug delivery systems. Particle diameter may determine drug biodistribution, cellular uptake, and elimination path. Solvent evaporation technique is a flexible method of particle preparation, in which various macromolecules and drugs may be employed. Parameters of emulsion obtained as first step of particle preparation are crucial in terms of particle size, drug loading, and morphology. The aim of the study was to investigate the influence of emulsion preparation parameters on diameter of resulting particles. Impact of surfactant type and concentration, homogenization time, homogenization rate, phase ratio, and conjugate concentration were evaluated. Model drug lamivudine was covalently bound to polymer and applied in solvent evaporation method in order to overcome issues related to drug loading and provide method-independent incorporation. Synthesized drug-polymer conjugate and obtained particles were evaluated via dynamic light scattering, chromatography, scanning electron microscopy, and spectroscopic methods. Covalent bonding between drug and polymeric chain was confirmed, estimated drug content per milligram of conjugate was 19 mu g. Among employed colloid stabilizer, poly(vinyl alcohol) was proven to be most effective. Homogenization rate and surfactant concentration were identified as crucial parameters in terms of particle diameter control. LA - English DB - MTMT ER - TY - JOUR AU - Abdelkader, Dalia H AU - El-Gizawy, Sanaa A AU - Faheem, Ahmed M AU - McCarron, Paul A AU - Osman, Mohamed A TI - Effect of process variables on formulation, in-vitro characterisation and subcutaneous delivery of insulin PLGA nanoparticles: An optimisation study JF - JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY J2 - J DRUG DELIV SCI TEC VL - 43 PY - 2018 SP - 160 EP - 171 PG - 12 SN - 1773-2247 DO - 10.1016/j.jddst.2017.10.004 UR - https://m2.mtmt.hu/api/publication/27555397 ID - 27555397 N1 - School of Pharmacy and Pharmaceutical Sciences, Saad Centre for Pharmacy and Diabetes, Ulster University, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, United Kingdom Faculty of Pharmacy, Pharmaceutical Technology Department, Tanta University, Tanta, 31111, Egypt Sunderland Pharmacy School, University of Sunderland, Sunderland, SR1 3SD, United Kingdom Cited By :10 Export Date: 21 February 2022 CODEN: JDDSA Correspondence Address: Abdelkader, D.H.; Pharmaceutical Technology Department, Egypt; email: mhdalia86@gmail.com Chemicals/CAS: insulin, 9004-10-8; insulin zinc suspension, 8049-62-5; macrogol, 25322-68-3 AB - This study was initiated to investigate the effect of PLGA concentration, PVA concentration, internal to external phase ratio (IEPR), PEG molecular weight and concentration on mean particle size, zeta potential, polydispersity index (PDI), percentage drug entrapment and in vitro release profile. Using PLGA (50: 50) as the carrier, insulin nanoparticles (NP) were prepared using double emulsion solvent evaporation technique. The particle size was analysed by dynamic light scattering (DLS) and the geometrical shape was examined using scanning electron microscopy (SEM). Mean particle size was highly dependent on the combined effect of PLGA and PVA concentrations. Drug entrapment would be greatly controlled by PLGA concentration and internal to external phase ratio. Addition of PEG could modulate in vitro release behavior of insulin with initial burst at the first 12 h and sustain the drug release for 6 days. Insulin integrity was assessed in vitro using MALDI-TOF mass spectroscopy. The optimised NP formulation, had particle size of 202.60 nm and percent entrapment efficiency (EE) equal to 67.72%, was tested in vivo to examine its hypoglycemic effect after subcutaneous injection. Insulin NP had a significant hypoglycemic effect comparing to free insulin (p < 0.01) and insulin zinc suspension (p < 0.05). LA - English DB - MTMT ER - TY - JOUR AU - Abdelkader, Dalia H. AU - Tambuwala, Murtaza M. AU - Mitchell, Christopher A. AU - Osman, Mohamed A. AU - El-Gizawy, Sanaa A. AU - Faheem, Ahmed M. AU - El-Tanani, Mohamed AU - McCarron, Paul A. TI - Enhanced cutaneous wound healing in rats following topical delivery of insulin-loaded nanoparticles embedded in poly(vinyl alcohol)-borate hydrogels JF - DRUG DELIVERY AND TRANSLATIONAL RESEARCH J2 - DRUG DELIV TRANSLAT RES VL - 8 PY - 2018 IS - 5 SP - 1053 EP - 1065 PG - 13 SN - 2190-393X DO - 10.1007/s13346-018-0554-0 UR - https://m2.mtmt.hu/api/publication/30448506 ID - 30448506 N1 - School of Pharmacy and Pharmaceutical Sciences, Saad Centre for Pharmacy and Diabetes, Ulster University, Cromore Road, Coleraine, Co., Londonderry, BT52 1SA, United Kingdom Faculty of Pharmacy, Pharmaceutical Technology Department, Tanta University, Tanta, 31111, Egypt School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine Co., Londonderry, BT52 1SA, United Kingdom Sunderland Pharmacy School, University of Sunderland, Sunderland, SR1 3SD, United Kingdom Institute of Cancer Therapeutics, University of Bradford, Bradford, West Yorkshire BD7 1DP, United Kingdom Cited By :23 Export Date: 21 February 2022 Correspondence Address: McCarron, P.A.; School of Pharmacy and Pharmaceutical Sciences, Cromore Road, Coleraine, Co., United Kingdom; email: p.mccarron@ulster.ac.uk Chemicals/CAS: boric acid, 10043-35-3, 11113-50-1, 11129-12-7, 14213-97-9; polyglactin, 26780-50-7, 34346-01-5; polyvinyl alcohol, 37380-95-3, 9002-89-5; insulin, 9004-10-8; streptozocin, 18883-66-4; Borates; Insulin; Polyvinyl Alcohol; polyvinyl alcohol hydrogel; Streptozocin Funding details: Ministry of Higher Education, MOHE AB - Insulin plays an important role in the wound healing process. but its method of delivery to the wound bed and subsequent effect on rate of healing is less well investigated. In this study, we evaluated the therapeutic effectiveness of topical human insulin delivery using a nanoparticulate delivery system suspended in a structured hydrogel vehicle. Poly(lactide-co-glycolide) (PLGA) nanoparticles (NP) of 202.6 nm diameter and loaded with 33.86 mu g insulin per milligram of polymer were formulated using a modified double-emulsion solvent evaporation technique and dispersed in a dilatant hydrogel (poly(vinyl alcohol)-borate). Importantly, this hydrogel formulation was used to achieve ultimate contact with the wound bed. A comparison of wound healing rates following local administration of insulin in the free and nanoencapsulated forms was performed in diabetic and healthy rats. In non-diabetic rats, there was no significant difference between healing observed in control and wounds treated with free insulin (p > 0.05), whereas treatment with insulin encapsulated within PLGA NP showed a significant difference (p < 0.001). In diabetic cohorts, both free insulin and nanoencapsulated insulin induced significant improvement in wound healing when compared to controls, with better percentage wound injury indices observed with the colloidal formulation. At day 10 of the experiment, the difference between percentage wound injury indices of insulin-PLGA NP and free insulin comparing to their controls were 29.15 and 12.16%, respectively. These results support strongly the potential of insulin-loaded colloidal carriers for improved wound healing when delivered using dilatant hydrogel formulations. LA - English DB - MTMT ER - TY - JOUR AU - Duan, Jianwei AU - Liu, Chao AU - Liang, Xiaoyu AU - Li, Xuanling AU - Chen, Youlu AU - Chen, Zuoguan AU - Wang, Xiaoli AU - Kong, Deling AU - Li, Yongjun AU - Yang, Jing TI - Protein delivery nanosystem of six-arm copolymer poly(epsilon-caprolactone)-poly(ethylene glycol) for long-term sustained release JF - INTERNATIONAL JOURNAL OF NANOMEDICINE J2 - INT J NANOMED VL - 13 PY - 2018 SP - 2743 EP - 2754 PG - 12 SN - 1176-9114 DO - 10.2147/IJN.S161006 UR - https://m2.mtmt.hu/api/publication/27555398 ID - 27555398 N1 - Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China Department of Vascular Surgery, Beijing Hospital, National Center of Gerontology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin, China Cited By :5 Export Date: 21 February 2022 Correspondence Address: Wang, X.; Institute of Biomedical Engineering, 236 Baidi Road, Nankai District, China; email: 506450568@qq.com Chemicals/CAS: macrogol, 25322-68-3; ovalbumin, 77466-29-6; polycaprolactone, 24980-41-4, 25248-42-4; tin, 14314-35-3, 7440-31-5; 2-ethylhexanoic acid tin(II) salt; Caproates; Delayed-Action Preparations; Drug Carriers; Ovalbumin; polycaprolactone; Polyesters; Polyethylene Glycols; Tin Manufacturers: Sigma Aldrich, United States Funding details: 2017-I2M-1-016 Funding details: National Natural Science Foundation of China, NSFC, 31600743, 31771097 Funding details: Tianjin Research Program of Application Foundation and Advanced Technology of China, 16JCQNJC13900, 17JCZDJC37400 Funding text 1: The authors are grateful for the financial support from the National Natural Science Funds of China (31771097, 31600743), Tianjin Research Program of Application Foundation and Advanced Technology (17JCZDJC37400, 16JCQNJC13900), CAMS Innovation Fund for Medical Sciences (2017-I2M-1-016), and Tianjin Innovation and Promotion Plan Key Innovation Team of Immunoreactive Biomaterials. LA - English DB - MTMT ER - TY - JOUR AU - Hajavi, Jafar AU - Ebrahimian, Mahboubeh AU - Sankian, Mojtaba AU - Khakzad, Mohammad Reza AU - Hashemi, Maryam TI - Optimization of PLGA formulation containing protein or peptide-based antigen: Recent advances JF - JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A J2 - J BIOMED MATER RES A VL - 106 PY - 2018 IS - 9 SP - 2540 EP - 2551 PG - 12 SN - 1549-3296 DO - 10.1002/jbm.a.36423 UR - https://m2.mtmt.hu/api/publication/30448505 ID - 30448505 N1 - Department of Basic Sciences, Faculty of Allied Medicine, Gonabad University of Medical Sciences, Gonabad, Iran Immunology Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran Division of Biotechnology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Innovated Medical Research Center & Department of Immunology, Mashhad Branch, Islamic Azad University, Mashhad, Iran Nanotechnology Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran Cited By :12 Export Date: 21 February 2022 CODEN: JBMRC Correspondence Address: Hashemi, M.; Nanotechnology Research Center, Iran; email: hashemim@mums.ac.ir Chemicals/CAS: protein, 67254-75-5; Antigens; Peptides; Polylactic Acid-Polyglycolic Acid Copolymer; Proteins AB - Protein or peptide-based antigens are the most promising forms to generate custom protective immune responses for clinical applications. Over the last decades, poly(lactic-co-glycolic acid) (PLGA) as a biodegradable polymer has gained more attention for delivery of protein and peptide. Besides many appropriate characteristics, to improve its properties to overcome some obstacles such as release profile and it is important instability of antigen during both encapsulation and storage. Therefore, optimized procedures conditions require to be used to maintain the integrity of protein structure under several stress factors in formulation process. In this review article, the properties of PLGA particles, their preparation techniques and strategies for improvement of protein stability during encapsulation into PLGA, release from particle and storage as well as stabilization approaches were summarized. (c) 2018 Wiley Periodicals, Inc. J. Biomed. Mater. Res. Part A: 106A: 2540-2551, 2018 LA - English DB - MTMT ER - TY - JOUR AU - He, Lei AU - Hu, Jing AU - Deng, Weijun TI - Preparation and application of flavor and fragrance capsules JF - POLYMER CHEMISTRY J2 - POLYM CHEM-UK VL - 9 PY - 2018 IS - 40 SP - 4926 EP - 4946 PG - 22 SN - 1759-9962 DO - 10.1039/c8py00863a UR - https://m2.mtmt.hu/api/publication/30448504 ID - 30448504 N1 - Cited By :40 Export Date: 21 February 2022 Correspondence Address: Hu, J.; School of Perfume and Aroma Technology, China; email: hujing616@126.com Funding details: 18090503500 Funding details: Natural Science Foundation of Shanghai, 17ZR1429800 Funding details: National Natural Science Foundation of China, NSFC, 51773116 Funding text 1: This research is supported by the National Natural Science Foundation of China (51773116), the Shanghai Natural Science Foundation (17ZR1429800) and the Shanghai Capacity-building Project (18090503500). AB - Flavors and fragrances in special active materials are applied widely in daily life, which can bring pleasant olfactory and gustatory sensations. However, their many ingredients are chemically unstable and susceptible to deterioration and loss when the flavor and fragrance are exposed to oxygen, light and heat. Nano and micrometer size capsules with a hollow core domain and a shell can effectively protect the stability of the flavor and fragrance and control their release. The structures and properties of flavor and fragrance capsules can be interestingly tailored by choosing a variety of shell materials. In this review, we give a brief overview with regard to the different preparation methods of flavor and fragrance capsules based on the type of wall material, including polymeric, inorganic and polymeric-inorganic materials. Besides, the application of flavor and fragrance capsules in food, tobacco, care products, textiles, leather and paper is briefly summarized. Moreover, the development trends of flavor and fragrance capsules are prospected. LA - English DB - MTMT ER - TY - JOUR AU - Park, Min-Ho AU - Jun, Hye-Suk AU - Jeon, Jong-Woon AU - Park, Jin-Kyu AU - Lee, Bong-Joo AU - Suh, Guk-Hyun AU - Park, Jeong-Sook AU - Cho, Cheong-Weon TI - Preparation and characterization of bee venom-loaded PLGA particles for sustained release JF - PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY J2 - PHARM DEV TECHNOL VL - 23 PY - 2018 IS - 9 SP - 857 EP - 864 PG - 8 SN - 1083-7450 DO - 10.1080/10837450.2016.1264415 UR - https://m2.mtmt.hu/api/publication/30448503 ID - 30448503 N1 - College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon, South Korea Wissen Co, Ltd, Daejeon, South Korea College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea Cited By :8 Export Date: 21 February 2022 CODEN: PDTEF Correspondence Address: Cho, C.-W.; College of Pharmacy and Institute of Drug Research and Development, 99 Daehak-ro, Yuseong-gu, South Korea; email: chocw@cnu.ac.kr Chemicals/CAS: polyglactin, 26780-50-7, 34346-01-5; Bee Venoms; Delayed-Action Preparations; Drug Carriers; Polylactic Acid-Polyglycolic Acid Copolymer AB - Bee venom-loaded poly(lactic-co-glycolic acid) (PLGA) particles were prepared by double emulsion-solvent evaporation, and characterized for a sustained-release system. Factors such as the type of organic solvent, the amount of bee venom and PLGA, the type of PLGA, the type of polyvinyl alcohol, and the emulsification method were considered. Physicochemical properties, including the encapsulation efficiency, drug loading, particle size, zeta-potential and surface morphology were examined by Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction (XRD). The size of the bee venom-loaded PLGA particles was 500 nm (measured using sonication). Zeta-potentials of the bee venom-loaded PLGA particles were negative owing to the PLGA. FT-IR results demonstrated that the bee venom was completely encapsulated in the PLGA particles, indicated by the disappearance of the amine and amide peaks. In addition, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis indicated that the bee venom in the bee venom-loaded PLGA particles was intact. In vitro release of the bee venom from the bee venom-loaded PLGA particles showed a sustained-release profile over 1 month. Bee venom-loaded PLGA particles can help improve patients' quality of life by reducing the number of injections required. LA - English DB - MTMT ER - TY - JOUR AU - Tasker, Alison L AU - Puttick, Simon AU - Hitchcock, James AU - Cayre, Olivier J AU - Blakey, Idriss AU - Whittaker, Andrew K AU - Biggs, Simon TI - A two-step synthesis for preparing metal microcapsules with a biodegradable polymer substrate JF - JOURNAL OF MATERIALS CHEMISTRY B J2 - J MATER CHEM B VL - 6 PY - 2018 IS - 14 SP - 2151 EP - 2158 PG - 8 SN - 2050-750X DO - 10.1039/c8tb00348c UR - https://m2.mtmt.hu/api/publication/27555396 ID - 27555396 N1 - Cited By :8 Export Date: 21 February 2022 CODEN: JMCBD Correspondence Address: Tasker, A.L.; School of Chemical Engineering, Australia; email: a.tasker@uq.edu.au Funding details: Australian National Fabrication Facility, ANFF Funding details: University of Queensland, UQ Funding text 1: The authors acknowledge the University of Queensland for the award of an Early Career Researcher Grant to ALT to enable this work to be conducted. We also acknowledge the facilities, and the scientific and technical assistance, of the Australian Microscopy & Microanalysis Research Facility at the Centre for Microscopy and Microanalysis, The University of Queensland, and we specifically thank Dr Robyn Webb for running the SEM 3View. This work was performed in part at the Queensland node of the Australian National Fabrication Facility (ANFF). LA - English DB - MTMT ER - TY - JOUR AU - Adebileje, Tajudeen AU - Valizadeh, Alireza AU - Amani, Amir TI - Effect of formulation parameters on the size of PLGA nanoparticles encapsulating bovine serum albumin: a response surface methodology JF - JOURNAL OF CONTEMPORARY MEDICAL SCIENCES J2 - JOURNAL OF CONTEMPORARY MEDICAL SCIENCES VL - 3 PY - 2017 IS - 12 SP - 306 EP - 312 PG - 7 SN - 2413-0516 DO - 10.22317/jcms.12201704 UR - https://m2.mtmt.hu/api/publication/27331033 ID - 27331033 LA - English DB - MTMT ER - TY - JOUR AU - Cella, Claudia AU - Gerges, Irini AU - Milani, Paolo AU - Lenardi, Cristina AU - Argentiere, Simona TI - Calcium Stearate as an Effective Alternative to Poly(vinyl alcohol) in Poly-Lactic-co-Glycolic Acid Nanoparticles Synthesis JF - BIOMACROMOLECULES J2 - BIOMACROMOLECULES VL - 18 PY - 2017 IS - 2 SP - 452 EP - 460 PG - 9 SN - 1525-7797 DO - 10.1021/acs.biomac.6b01546 UR - https://m2.mtmt.hu/api/publication/26556331 ID - 26556331 N1 - Filarete Foundation, viale Ortles 22/4, Milano, 20139, Italy Cimaina and Dipartimento di Fisica, Università degli Studi di Milano, via Celoria 16, Milano, 20133, Italy SEMM, European School of Molecular Medicine, Campus IFOM-IEO, via Adamello 16, Milano, 20139, Italy Tensive S.r.l., via Timavo 34, Milano, 20124, Italy Cited By :4 Export Date: 20 February 2021 CODEN: BOMAF Correspondence Address: Cella, C.; Filarete Foundation, viale Ortles 22/4, Italy; email: claudia.cella@unimi.it LA - English DB - MTMT ER - TY - JOUR AU - Dhat, Shalaka AU - Pund, Swati AU - Kokare, Chandrakant AU - Sharma, Pankaj AU - Shrivastava, Birendra TI - Risk management and statistical multivariate analysis approach for design and optimization of satranidazole nanoparticles JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - EUR J PHARM SCI VL - 96 PY - 2017 SP - 273 EP - 283 PG - 11 SN - 0928-0987 DO - 10.1016/j.ejps.2016.09.035 UR - https://m2.mtmt.hu/api/publication/26380572 ID - 26380572 N1 - School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan 302017, India Department of Biosciences and Bioengineering, Indian Institute of Technology, Powai, Mumbai 400076, India Department of Pharmaceutics, S.T.E.S's Sinhgad Institute of Pharmacy, Narhe, Pune, Maharashtra 411041, India Cited By :21 Export Date: 21 February 2022 CODEN: EPSCE Correspondence Address: Dhat, S.; Department of Pharmaceutics, India; email: shalakapd@gmail.com Chemicals/CAS: acetone, 67-64-1; mannitol, 69-65-8, 87-78-5; satranidazole, 56302-13-7; Nitroimidazoles; satranidazole LA - English DB - MTMT ER - TY - JOUR AU - He, Zhenglong AU - Jiang, Shuai AU - Li, Qifeng AU - Wang, Junwei AU - Zhao, Yuhua AU - Kang, Maoqing TI - Facile and cost-effective synthesis of isocyanate microcapsules via polyvinyl alcohol-mediated interfacial polymerization and their application in self-healing materials JF - COMPOSITES SCIENCE AND TECHNOLOGY J2 - COMPOS SCI TECHNOL VL - 138 PY - 2017 SP - 15 EP - 23 PG - 9 SN - 0266-3538 DO - 10.1016/j.compscitech.2016.11.004 UR - https://m2.mtmt.hu/api/publication/26556332 ID - 26556332 N1 - Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan, 030001, China University of Chinese Academy of Sciences, Beijing, 100049, China National Engineering Research Center for Coal-Based Synthesis, Taiyuan, 030001, China Cited By :40 Export Date: 21 February 2022 CODEN: CSTCE Correspondence Address: Li, Q.; Institute of Coal Chemistry, China; email: liqf@sxicc.ac.cn Funding details: 20111101058 Funding text 1: The authors gratefully acknowledge financial support from the Major Science and Technology Project in Shanxi Province ( No. 20111101058 ). LA - English DB - MTMT ER - TY - JOUR AU - Prabhu, Suma AU - Ananthanarayanan, Preeta AU - Aziz, Sajida Kannangar AU - Rai, Sharada AU - Mutalik, Srinivas AU - Sadashiva, Satish Rao Bola TI - Enhanced effect of geldanamycin nanocomposite against breast cancer cells growing in vitro and as xenograft with vanquished normal cell toxicity JF - TOXICOLOGY AND APPLIED PHARMACOLOGY J2 - TOXICOL APPL PHARM VL - 320 PY - 2017 SP - 60 EP - 72 PG - 13 SN - 0041-008X DO - 10.1016/j.taap.2017.02.012 UR - https://m2.mtmt.hu/api/publication/26556330 ID - 26556330 N1 - Department of Radiation Biology and Toxicology, School of Life Sciences, Manipal University, Manipal, Karnataka 576 104, India Department of Biotechnology, School of Life Sciences, Manipal University, Manipal, Karnataka 576 104, India Department of Pathology, Kasturba Medical College, Mangalore Campus, Manipal University, Mangalore, Karnataka 575 001, India Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576 104, India Cited By :7 Export Date: 21 February 2022 CODEN: TXAPA Correspondence Address: Sadashiva, S.R.B.; Department of Radiation Biology & Toxicology, India; email: rao.satish@manipal.edu Chemicals/CAS: mitogen activated protein kinase, 142243-02-5; protein kinase B, 148640-14-6; superparamagnetic iron oxide, 119683-68-0; geldanamycin, 30562-34-6; Antibiotics, Antineoplastic; Benzoquinones; geldanamycin; Lactams, Macrocyclic LA - English DB - MTMT ER - TY - JOUR AU - Cella, Claudia AU - Martello, Federico AU - Ghisletti, Serena AU - Lenardi, Cristina AU - Milani, Paolo AU - Argentiere, Simona TI - Amine-modified poly(vinyl alcohol) as a novel surfactant to modulate size and surface charge of poly(lactide-co-glycolide) nanoparticles JF - POLYMER INTERNATIONAL J2 - POLYM INT VL - 65 PY - 2016 IS - 7 SP - 792 EP - 797 PG - 6 SN - 0959-8103 DO - 10.1002/pi.5122 UR - https://m2.mtmt.hu/api/publication/26022938 ID - 26022938 N1 - Fondazione Filarete, Viale Ortles 22/4, Milan, 20139, Italy CIMAINA, Dipartimento di Fisica, Università degli Studi di Milano, Via Celoria 16, Milan, 20133, Italy SEMM, European School of Molecular Medicine, Campus IFOM-IEO, Via Adamello 16, Milan, 20139, Italy Tensive s.r.l., Via Timavo 34, Milan, 20124, Italy Department of Experimental Oncology, European Institute of Oncology (IEO), IFOM-IEO Campus, Via Adamello 16, Milan, 20139, Italy Cited By :3 Export Date: 21 February 2022 Correspondence Address: Argentiere, S.; Fondazione Filarete, Viale Ortles 22/4, Italy; email: simona.argentiere@fondazionefilarete.com LA - English DB - MTMT ER - TY - JOUR AU - Dutta, Dipankar AU - Salifu, Mariama AU - Sirianni, Rachael W AU - Stabenfeldt, Sarah E TI - Tailoring sub-micron PLGA particle release profiles via centrifugal fractioning JF - JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A J2 - J BIOMED MATER RES A VL - 104 PY - 2016 IS - 3 SP - 688 EP - 696 PG - 9 SN - 1549-3296 DO - 10.1002/jbm.a.35608 UR - https://m2.mtmt.hu/api/publication/25776105 ID - 25776105 N1 - School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States Barrow Brain Tumor Research Center, Barrow Neurological Institute, Phoenix, AZ, United States Cited By :9 Export Date: 21 February 2022 CODEN: JBMRC Correspondence Address: Sirianni, R.W.; Barrow Neurological Institute, 350 W Thomas Rd, United States; email: rachael.sirianni@dignityhealth.org Chemicals/CAS: protein, 67254-75-5; polyglycolic acid, 26009-03-0, 26124-68-5, 26202-08-4; Polyglycolic Acid; Serum Albumin, Bovine Funding details: National Science Foundation, NSF, 1454282 Funding details: Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD, DP2HD084067 LA - English DB - MTMT ER - TY - JOUR AU - Feczko, Tivadar AU - Fodor-Kardos, Andrea AU - Sivakumaran, Muttuswamy AU - Shubhra, Quazi Tanminul Haque TI - In vitro IFN-alpha release from IFN-alpha- and pegylated IFN-alpha-loaded poly(lactic-co-glycolic acid) and pegylated poly(lactic-coglycolic acid) nanoparticles JF - NANOMEDICINE J2 - NANOMEDICINE-UK VL - 11 PY - 2016 IS - 16 SP - 2029 EP - 2034 PG - 6 SN - 1743-5889 DO - 10.2217/nnm-2016-0058 UR - https://m2.mtmt.hu/api/publication/26238512 ID - 26238512 LA - English DB - MTMT ER - TY - JOUR AU - Fernandes, Margarida M. AU - Ivanova, Kristina AU - Francesko, Antonio AU - Rivera, Diana AU - Torrent-Burgues, Juan AU - Gedanken, Aharon AU - Mendonza, Ernest AU - Tzanov, Tzanko TI - Escherichia coli and Pseudomonas aeruginosa eradication by nano-penicillin G JF - NANOMEDICINE: NANOTECHNOLOGY BIOLOGY AND MEDICINE J2 - NANOMED: NANOTECHNOL VL - 12 PY - 2016 IS - 7 SP - 2061 EP - 2069 PG - 9 SN - 1549-9634 DO - 10.1016/j.nano.2016.05.018 UR - https://m2.mtmt.hu/api/publication/30448509 ID - 30448509 N1 - Grup de Biotecnologia Molecular i Industrial, Department d'Enginyeria Química, Universitat Politècnica de Catalunya, Rambla Sant Nebridi 22, Spain Department of Chemistry, Institute of Nanotechnology and Advanced Materials, BarIlan University, Israel Laboratory of Applied Nanomaterials, Center for Research in NanoEngineering, Universitat Politècnica de Catalunya, c/ Pascual I Vila 15, Barcelona, Spain Cited By :15 Export Date: 21 February 2022 Correspondence Address: Tzanov, T.; Grup de Biotecnologia Molecular i Industrial, Rambla Sant Nebridi 22, Spain; email: tzanko.tzanov@upc.edu Chemicals/CAS: hydrogen, 12385-13-6, 1333-74-0; penicillin G, 1406-05-9, 61-33-6; Anti-Bacterial Agents; beta-Lactams; Penicillin G Manufacturers: Sigma Aldrich, Spain Funding details: Instituto de Estudios Fiscales, IEF, 331416 Funding details: Marie Curie Funding text 1: The research leading to these results has received funding from the European Community's Seventh Framework Program FP7 under the Marie Curie Intra-European Fellowship (IEF) project NanoQuench (Grant agreement No. 331416). AB - The transformation of penicillin G into nano/micro-sized spheres ( nanopenicillin) using sonochemical technology was explored as a novel tool for the eradication of Gram-negative bacteria and their biofilms. Known by its effectiveness only against Gram-positive microorganisms, the penicillin G spherization boosted the inhibition of the Gram-negative Pseudomonas aeruginosa 10-fold ( from 0.3 to 3.0 log-reduction) and additionally induced 1.2 log-reduction of Escherichia coli growth. The efficient penetration of the spheres within a Langmuir monolayer sustained the theory that nanopenicillin is able to cross the membrane and reach the periplasmic space in Gram-negative bacteria where they inhibit the beta-lactam targets: the transferases that build the bacteria cell wall. Moreover, it considerably suppressed the growth of both bacterial biofilms on a medically relevant polystyrene surface, leaving majority of the adhered cells dead compared to the treatment with the non-processed penicillin G. Importantly, nanopenicillin was found innocuous towards human fibroblasts at the antibacterial-effective concentrations. (C) 2016 Elsevier Inc. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Lee, Wing-Hin AU - Loo, Ching-Yee AU - Ong, Hui-Xin AU - Traini, Daniela AU - Young, Paul M AU - Rohanizadeh, Ramin TI - Synthesis and Characterization of Inhalable Flavonoid Nanoparticle for Lung Cancer Cell Targeting JF - JOURNAL OF BIOMEDICAL NANOTECHNOLOGY J2 - J BIOMED NANOTECHNOL VL - 12 PY - 2016 IS - 2 SP - 371 EP - 386 PG - 16 SN - 1550-7033 DO - 10.1166/jbn.2016.2162 UR - https://m2.mtmt.hu/api/publication/25795145 ID - 25795145 N1 - Advanced Drug Delivery Group, Faculty of Pharmacy, University of SydneyNSW 2006, Australia Respiratory Technology, Woolcock Institute of Medical ResearchNSW 2006, Australia Discipline of Pharmacology, Sydney Medical SchoolNSW 2006, Australia Cited By :17 Export Date: 26 August 2021 Correspondence Address: Rohanizadeh, R.; Advanced Drug Delivery Group, Australia; email: ramin.rohanizadeh@sydney.edu.au LA - English DB - MTMT ER - TY - JOUR AU - Tasker, Alison Louise AU - Hitchcock, James Paul AU - He, Ling AU - Baxter, Elaine Alice AU - Biggs, Simon AU - Cayre, Olivier Jean TI - The effect of surfactant chain length on the morphology of poly(methyl methacrylate) microcapsules for fragrance oil encapsulation JF - JOURNAL OF COLLOID AND INTERFACE SCIENCE J2 - J COLLOID INTERF SCI VL - 484 PY - 2016 SP - 10 EP - 16 PG - 7 SN - 0021-9797 DO - 10.1016/j.jcis.2016.08.058 UR - https://m2.mtmt.hu/api/publication/26380573 ID - 26380573 N1 - Faculty of Engineering, Architecture and Information Technology, University of Queensland, St Lucia, Queensland 4072, Australia School of Chemical and Process Engineering, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom Procter & Gamble, London Innovation Centre, Rusham Park, Whitehall Ln, Egham, TW20 9NW, United Kingdom Cited By :26 Export Date: 21 February 2022 CODEN: JCISA Correspondence Address: Tasker, A.L.; Faculty of Engineering, Australia; email: a.tasker@uq.edu.au Chemicals/CAS: dichloromethane, 75-09-2; hexadecane, 544-76-3; poly(methyl methacrylate), 39320-98-4, 9008-29-1; dodecyltrimethylammonium, 10182-91-9; water, 7732-18-5; Alkanes; Capsules; dodecyltrimethylammonium; Methylene Chloride; n-hexadecane; Oils, Volatile; Polymethyl Methacrylate; Quaternary Ammonium Compounds; Surface-Active Agents; Water Funding details: Engineering and Physical Sciences Research Council, EPSRC, EP/J500458/1, EP/K503836/1 Funding text 1: The authors acknowledge the EPSRC for grant numbers EP/J500458/1 and EP/K503836/1 , providing us with the funding to complete this work. We also acknowledge the funding received from Procter and Gamble . The authors also acknowledge the facilities, and the scientific and technical assistance, of the Australian Microscopy & Microanalysis Research Facility at the Centre for Microscopy and Microanalysis, The University of Queensland, and the Leeds Electron Microscopy and Spectroscopy Centre. LA - English DB - MTMT ER - TY - JOUR AU - Usman, Faisal AU - Javed, Ibrahim AU - Hussain, Syed Zajif AU - Ranjha, Nazar Muhammad AU - Hussain, Irshad TI - Hydrophilic nanoparticles packed in oral tablets can improve the plasma profile of short half-life hydrophobic drugs JF - RSC ADVANCES J2 - RSC ADV VL - 6 PY - 2016 IS - 97 SP - 94896 EP - 94904 PG - 9 SN - 2046-2069 DO - 10.1039/c6ra11799f UR - https://m2.mtmt.hu/api/publication/26380574 ID - 26380574 N1 - Drug Delivery System Excellence Center, Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand Faculty of Pharmacy, Bahauddin Zakariya University, Bosan Road, Multan, 60000, Pakistan Department of Chemistry, SBA-School of Science and Engineering, Lahore University of Management Sciences, DHA, Lahore Cantt, 54792, Pakistan Cited By :4 Export Date: 21 February 2022 CODEN: RSCAC Correspondence Address: Javed, I.; Department of Chemistry, Pakistan; email: ibr_pharmacist@yahoo.com LA - English DB - MTMT ER - TY - JOUR AU - Baghaei, Bahareh AU - Jafari, Seyed Hassan AU - Khonakdar, Hossein Ali AU - Saeb, Mohammad Reza AU - Wagenknecht, Udo AU - Heinrich, Gert TI - A Multioptimization Approach to Assessment of Drug Delivery of PLGA Nanoparticles: Simultaneous Control of Particle Size and Release Behavior JF - INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS J2 - INT J POLYM MATER PO VL - 64 PY - 2015 IS - 12 SP - 641 EP - 652 PG - 12 SN - 0091-4037 DO - 10.1080/00914037.2014.996714 UR - https://m2.mtmt.hu/api/publication/24789021 ID - 24789021 N1 - School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, 11155-4563, Iran Nano-Biomedicine Center of Excellence, Nano-Science and Nano-Technology Research Center, University of Tehran, Tehran, Iran Iran Polymer and Petrochemical Institute, Tehran, Iran Leibniz Institute of Polymer Research Dresden, Dresden, Germany Department of Resin and Additives, Institute for Color Science and Technology, Tehran, Iran Cited By :13 Export Date: 21 February 2022 CODEN: IJPMC Correspondence Address: Jafari, S.H.; School of Chemical Engineering, Iran; email: shjafari@ut.ac.ir Funding text 1: This work was financially supported by the Iranian Nanotechnology Initiative. LA - English DB - MTMT ER - TY - JOUR AU - Khalid, Nauman AU - Kobayashi, Isao AU - Neves, Marcos A AU - Uemura, Kunihiko AU - Nakajima, Mitsutoshi AU - Nabetani, Hiroshi TI - Preparation of monodisperse aqueous microspheres containing high concentration of L-ascorbic acid by microchannel emulsification JF - JOURNAL OF MICROENCAPSULATION J2 - J MICROENCAPSUL VL - 32 PY - 2015 IS - 6 SP - 570 EP - 577 PG - 8 SN - 0265-2048 DO - 10.3109/02652048.2015.1065919 UR - https://m2.mtmt.hu/api/publication/25310311 ID - 25310311 N1 - Food Engineering Division, National Food Research Institute, NARO, 2-1-12 Kannondai, Ibaraki, 305-8642, Japan Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan Cited By :6 Export Date: 21 February 2022 CODEN: JOMIE Correspondence Address: Kobayashi, I.; Food Engineering Division, 2-1-12 Kannondai, Japan; email: isaok@affrc.go.jp Chemicals/CAS: alginic acid, 28961-37-7, 29894-36-8, 9005-32-7, 9005-38-3; ascorbic acid, 134-03-2, 15421-15-5, 50-81-7; barium ion, 22541-12-4; calcium ion, 14127-61-8; dodecyl sulfate sodium, 151-21-3; magnesium ion, 22537-22-0; magnesium sulfate, 7487-88-9; polyglactin, 26780-50-7, 34346-01-5; strontium, 7440-24-6; zinc ion, 23713-49-7; glucuronic acid, 36116-79-7, 576-37-4, 6556-12-3; sodium, 7440-23-5; water, 7732-18-5; Alginates; alginic acid; Ascorbic Acid; Emulsifying Agents; Emulsions; Glucuronic Acid; Hexuronic Acids; Ions; Magnesium Sulfate; Sodium; Water LA - English DB - MTMT ER - TY - JOUR AU - Ortega-Oller, Inmaculada AU - Padial-Molina, Miguel AU - Galindo-Moreno, Pablo AU - O'Valle, Francisco AU - Belen, Jodar-Reyes Ana AU - Manuel, Peula-Garcia Jose TI - Bone Regeneration from PLGA Micro-Nanoparticles JF - BIOMED RESEARCH INTERNATIONAL J2 - BIOMED RES INT VL - 2015 PY - 2015 PG - 18 SN - 2314-6133 DO - 10.1155/2015/415289 UR - https://m2.mtmt.hu/api/publication/26694752 ID - 26694752 N1 - Department of Oral Surgery and Implant Dentistry, University of Granada, Granada, 18011, Spain Department of Pathology, School of Medicine and IBIMER, University of Granada, Granada, 18012, Spain Biocolloid and Fluid Physics Group, Department of Applied Physics, University of Granada, Granada, 18071, Spain Department of Applied Physics II, University of Málaga, Malaga, 29071, Spain Cited By :44 Export Date: 21 February 2022 Correspondence Address: Peula-García, J.M.; Biocolloid and Fluid Physics Group, Department of Applied Physics, University of GranadaSpain Chemicals/CAS: polyglactin, 26780-50-7, 34346-01-5; lactic acid, 113-21-3, 50-21-5; polyglycolic acid, 26009-03-0, 26124-68-5, 26202-08-4; Biocompatible Materials; BMP2 protein, human; Bone Morphogenetic Protein 2; Colloids; Drug Carriers; Hydrogels; Lactic Acid; Polyglycolic Acid; polylactic acid-polyglycolic acid copolymer; Polymers; Solvents Funding details: Seventh Framework Programme, FP7, 291780 LA - English DB - MTMT ER - TY - JOUR AU - Ribeiro, Ana Ferreira AU - Garruth, Ferreira Carina Torres AU - dos, Santos Juliana Fernandes AU - Cabral, Lucio Mendes AU - de Sousa, Valeria Pereira TI - Design of experiments for the development of poly(D,L-lactide-co-glycolide) nanoparticles loaded with Uncaria tomentosa JF - JOURNAL OF NANOPARTICLE RESEARCH J2 - J NANOPART RES VL - 17 PY - 2015 IS - 2 PG - 16 SN - 1388-0764 DO - 10.1007/s11051-015-2883-y UR - https://m2.mtmt.hu/api/publication/24789020 ID - 24789020 N1 - Department of Drugs and Pharmaceutics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Faculty of Pharmacy, Federal Institute of Education, Science and Technology of Rio de Janeiro, R. Prof. Carlos Wenceslau 343, Realengo, Rio de Janeiro, RJ 25715-000, Brazil Cited By :12 Export Date: 21 February 2022 Correspondence Address: Ribeiro, A.F.; Faculty of Pharmacy, R. Prof. Carlos Wenceslau 343, Realengo, Brazil; email: ana.ribeiro@ifrj.edu.br Chemicals/CAS: acetic acid ethyl ester, 141-78-6; acetone, 67-64-1; poloxamer, 9003-11-6; polyglactin, 26780-50-7, 34346-01-5 Funding details: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES Funding details: Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, FAPERJ Funding text 1: This work was supported by FAPERJ and CAPES Edital CAPES Nanobiotecnologia 2008. The authors wish to thank the Herbarium Laboratório Botânico Ltda., IFRJ, LADEQ/UFRJ, and EngePol/COPPE/UFRJ. LA - English DB - MTMT ER - TY - JOUR AU - Salatin, Sara AU - Dizaj, Solmaz Maleki AU - Khosroushahi, Ahmad Yari TI - Effect of the surface modification, size, and shape on cellular uptake of nanoparticles JF - CELL BIOLOGY INTERNATIONAL J2 - CELL BIOL INT VL - 39 PY - 2015 IS - 8 SP - 881 EP - 890 PG - 10 SN - 1065-6995 DO - 10.1002/cbin.10459 UR - https://m2.mtmt.hu/api/publication/25081730 ID - 25081730 N1 - Biotechnology Research Center, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran Drug Applied Research Center, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran Cited By :246 Export Date: 21 February 2022 CODEN: CBIIE Correspondence Address: Yari Khosroushahi, A.; Drug Applied Research Center, Iran; email: Yarikhosroushahia@tbzmed.ac.ir Chemicals/CAS: chitosan, 9012-76-4; cyclodextrin, 12619-70-4; iron oxide, 1332-37-2; leucine enkephalin[2 dextro alanine 6 arginine], 81733-79-1; loperamide, 34552-83-5, 53179-11-6; macrogol, 25322-68-3; poloxamer, 9003-11-6; polyethyleneimine, 74913-72-7; polyglactin, 26780-50-7, 34346-01-5; polysorbate 80, 8050-83-7, 9005-65-6; polystyrene, 9003-53-6; polyvinyl alcohol, 37380-95-3, 9002-89-5; Drug Carriers LA - English DB - MTMT ER - TY - JOUR AU - Baghaei, B AU - Jafari, SH AU - Khonakdar, HA AU - Wagenknecht, U AU - Heinrich, G TI - Novel Thermosensitive Hydrogel Composites Based on Poly(D,L-lactide-co-glycolide) Nanoparticles Embedded in Poly(N-isopropyl acrylamide) with Sustained Drug-Release Behavior JF - JOURNAL OF APPLIED POLYMER SCIENCE J2 - J APPL POLYM SCI VL - 131 PY - 2014 IS - 16 PG - 7 SN - 0021-8995 DO - 10.1002/app.40625 UR - https://m2.mtmt.hu/api/publication/24535898 ID - 24535898 N1 - School of Chemical Engineering College of Engineering, University of Tehran, 11155-4563 Tehran, Iran Nano-Biomedicine Center of Excellence, Nano-Science and Nano-Technology Research Center, University of Tehran, Tehran, Iran Iran Polymer and Petrochemical Institute, Tehran 14965-115, Iran Leibniz Institute of Polymer Research Dresden, Hohe Strasse 6, D-01069 Dresden, Germany Cited By :8 Export Date: 21 February 2022 CODEN: JAPNA Correspondence Address: Jafari, S.H.; School of Chemical Engineering College of Engineering, University of Tehran, 11155-4563 Tehran, Iran; email: shjafari@ut.ac.ir LA - English DB - MTMT ER - TY - JOUR AU - Marquette, S AU - Peerboom, C AU - Yates, A AU - Denis, L AU - Goole, J AU - Amighi, K TI - Encapsulation of immunoglobulin G by solid-in-oil-in-water: Effect of process parameters on microsphere properties JF - EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS J2 - EUR J PHARM BIOPHARM VL - 86 PY - 2014 IS - 3 SP - 393 EP - 403 PG - 11 SN - 0939-6411 DO - 10.1016/j.ejpb.2013.10.013 UR - https://m2.mtmt.hu/api/publication/24535899 ID - 24535899 N1 - Laboratory of Pharmaceutics and Biopharmaceutics, Université Libre de Bruxelles (ULB), Brussels, Belgium UCB Pharma S.A., Chemin du Foriest, 1420 Braine-L'Alleud, Belgium Cited By :31 Export Date: 21 February 2022 CODEN: EJPBE Correspondence Address: Marquette, S.; UCB Pharma S.A., Chemin du Foriest, 1420 Braine-L'Alleud, Belgium; email: sarah.marquette@ucb.com Chemicals/CAS: acetic acid ethyl ester, 141-78-6; dichloromethane, 75-09-2; immunoglobulin G, 97794-27-9; polyglactin, 26780-50-7, 34346-01-5; lactic acid, 113-21-3, 50-21-5; polyglycolic acid, 26009-03-0, 26124-68-5, 26202-08-4; Immunoglobulin G; Lactic Acid; Polyglycolic Acid; polylactic acid-polyglycolic acid copolymer LA - English DB - MTMT ER - TY - JOUR AU - Sharma, D AU - Gabrani, R AU - Sharma, S K AU - Ali, J AU - Dang, S TI - Development of midazolam loaded poly(D, L-lactide-co-glycolic acid) nanoparticles for treatment of status epilepticus JF - RESEARCH IN PHARMACEUTICAL SCIENCES J2 - RES PHARM SCI VL - 9 PY - 2014 IS - 6 SP - 407 EP - 420 PG - 14 SN - 1735-5362 DO - 10.1166/as1.2014.5520 UR - https://m2.mtmt.hu/api/publication/24584069 ID - 24584069 N1 - Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran Deptartment of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Department of Pharmaceutics, Faculty of Pharmacy, Medical Biomaterials Research Centre (MBRC), Tehran, Iran Center for Nanotechnology in Drug Delivery, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran Cited By :22 Export Date: 21 February 2022 Correspondence Address: Samani, S.M.; Pharmaceutical Sciences Research Center, Iran Chemicals/CAS: 2 hydroxypropyl beta cyclodextrin, 94035-02-6, 128446-35-5; hyaluronic acid, 31799-91-4, 9004-61-9, 9067-32-7; polyglactin, 26780-50-7, 34346-01-5; polysorbate 80, 8050-83-7, 9005-65-6; sorbitan oleate, 1338-43-8 Funding details: 90-5700 LA - English DB - MTMT ER - TY - JOUR AU - Shubhra, Quazi Tanminul Haque AU - Fodorné Kardos, Andrea AU - Feczkó, Tivadar AU - Mackova, H AU - Horák, D AU - Tóth, Judit AU - Dósa, György AU - Gyenis, János TI - Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size. JF - JOURNAL OF MICROENCAPSULATION J2 - J MICROENCAPSUL VL - 31 PY - 2014 IS - 2 SP - 147 EP - 155 PG - 9 SN - 0265-2048 DO - 10.3109/02652048.2013.814729 UR - https://m2.mtmt.hu/api/publication/2568095 ID - 2568095 N1 - Doctoral School of Molecular and Nanotechnologies, Faculty of Information Technology, University of Pannonia, Egyetem u.10, H-8200 Veszprém, Hungary Research Institute of Chemical and Process Engineering, Faculty of Information Technology, University of Pannonia, Egyetem u.10, H-8200 Veszprém, Hungary Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences, Pusztaszeri u. 59-67, H-1025 Budapest, Hungary Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 16206 Prague 6, Czech Republic Department of Mathematics, Faculty of Information Technology, University of Pannonia, Egyetem u. 10, Veszprém, Hungary Cited By :13 Export Date: 21 February 2022 CODEN: JOMIE Correspondence Address: Shubhra, Q.T.H.; Doctoral School of Molecular and Nanotechnologies, Egyetem u.10, H-8200 Veszprém, Hungary; email: shubhro.du@gmail.com Funding details: TÁMOP-4.2.2/B-10/1-2010-0025 Funding details: Seventh Framework Programme, FP7, 264722 Funding details: European Commission, EC Funding details: Academy of Sciences Republic of Uzbekistan, KAN401220801 Funding text 1: The authors gratefully acknowledge the financial support of European Commission granted through the ‘‘PowTech’’ Marie Curie Initial Training Network (Grant Agreement No: 264722), and the support of Hungarian National Programme of Social Development TÁMOP-4.2.2/B-10/1-2010-0025. The authors are also thankful to the bilateral academic exchange program of Hungarian Academy of Sciences and Academy of Sciences of the Czech Republic (project KAN401220801). LA - English DB - MTMT ER - TY - JOUR AU - Shubhra, Quazi Tanminul Haque AU - Feczkó, Tivadar AU - Fodorné Kardos, Andrea AU - Mackova, H AU - Horák, D AU - Tóth, Judit AU - Dósa, György AU - Gyenis, János TI - Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part II. Effect of process variables on protein model drug encapsulation efficiency. JF - JOURNAL OF MICROENCAPSULATION J2 - J MICROENCAPSUL VL - 31 PY - 2014 IS - 2 SP - 156 EP - 165 PG - 10 SN - 0265-2048 DO - 10.3109/02652048.2013.814730 UR - https://m2.mtmt.hu/api/publication/2568125 ID - 2568125 N1 - Doctoral School of Molecular and Nanotechnologies, Faculty of Information Technology, University of Pannonia, Egyetem u.10, H-8200 Veszprém, Hungary Research Institute of Chemical and Process Engineering, Faculty of Information Technology, University of Pannonia, Egyetem u.10, H-8200 Veszprém, Hungary Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences, Pusztaszeri u. 59-67, H-1025 Budapest, Hungary Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 16206 Prague 6, Czech Republic Department of Mathematics, Faculty of Information Technology, University of Pannonia, Egyetem u. 10, Veszprém, Hungary Cited By :14 Export Date: 21 February 2022 CODEN: JOMIE Correspondence Address: Shubhra, Q.T.H.; Doctoral School of Molecular and Nanotechnologies, Egyetem u.10, H-8200 Veszprém, Hungary; email: shubhro.du@gmail.com Funding details: KAN401220801 Funding details: TÁMOP-4.2.2/B-10/1-2010-0025 Funding details: Seventh Framework Programme, FP7, 264722 Funding details: European Commission, EC Funding text 1: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.The authors gratefully acknowledge the financial support of European Commission granted through the ‘‘PowTech’’ Marie Curie Initial Training Network (Grant Agreement No: 264722), and the support of Hungarian National Programme of Social Development TÁMOP-4.2.2/B-10/1-2010-0025. The authors are also thankful to the bilateral academic exchange program of Hungarian Academy of Sciences and Academy of Sciences of the Czech Republic (project KAN401220801). LA - English DB - MTMT ER - TY - JOUR AU - Shubhra, QTH AU - Toth, J AU - Gyenis, J AU - Feczko, T TI - Poloxamers for Surface Modification of Hydrophobic Drug Carriers and Their Effects on Drug Delivery JF - POLYMER REVIEWS J2 - POLYM REV VL - 54 PY - 2014 IS - 1 SP - 112 EP - 138 PG - 27 SN - 1558-3724 DO - 10.1080/15583724.2013.862544 UR - https://m2.mtmt.hu/api/publication/24535897 ID - 24535897 LA - English DB - MTMT ER - TY - JOUR AU - Shubhra, Quazi Tanminul Haque AU - Tóth, Judit AU - Gyenis, János AU - Feczkó, Tivadar TI - Surface modification of HSA containing magnetic PLGA nanoparticles by poloxamer to decrease plasma protein adsorption JF - COLLOIDS AND SURFACES B: BIOINTERFACES J2 - COLLOID SURFACE B VL - 122 PY - 2014 SP - 529 EP - 536 PG - 8 SN - 0927-7765 DO - 10.1016/j.colsurfb.2014.07.025 UR - https://m2.mtmt.hu/api/publication/2822838 ID - 2822838 N1 - Doctoral School of Molecular and Nanotechnologies, Faculty of Information Technology, University of Pannonia, Egyetem u.10, Veszprém, H-8200, Hungary Research Institute of Chemical and Process Engineering, Faculty of Information Technology, University of Pannonia, Egyetem u.10, Veszprém, H-8200, Hungary Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Budapest, H-1117, Hungary Cited By :37 Export Date: 21 February 2022 CODEN: CSBBE Correspondence Address: Shubhra, Q.T.H.; Doctoral School of Molecular and Nanotechnologies, Faculty of Information Technology, University of Pannonia, Egyetem u.10, Hungary Chemicals/CAS: human serum albumin, 9048-49-1; poloxamer, 9003-11-6; polyglactin, 26780-50-7, 34346-01-5; lactic acid, 113-21-3, 50-21-5; polyglycolic acid, 26009-03-0, 26124-68-5, 26202-08-4; serum albumin, 9048-46-8; Lactic Acid; Polyglycolic Acid; polylactic acid-polyglycolic acid copolymer; Serum Albumin Funding details: European Commission, EC, 264722 Funding text 1: We thank Prof. Ferenc Vonderviszt for instrumental support in the ITC analysis. The authors acknowledge the financial support of the European Commission granted through the “PowTech” Marie Curie Initial Training Network (Grant Agreement No. 264722 ). LA - English DB - MTMT ER - TY - JOUR AU - Azizi, M AU - Farahmandghavi, F AU - Joghataei, M AU - Zandi, M AU - Imani, M AU - Bakhtiary, M AU - Dorkoosh, FA AU - Ghazizadeh, F TI - Fabrication of protein-loaded PLGA nanoparticles: effect of selected formulation variables on particle size and release profile JF - JOURNAL OF POLYMER RESEARCH J2 - J POLYM RES VL - 20 PY - 2013 IS - 4 SN - 1022-9760 DO - 10.1007/s10965-013-0110-z UR - https://m2.mtmt.hu/api/publication/23285780 ID - 23285780 LA - English DB - MTMT ER - TY - JOUR AU - Shubhra, Quazi Tanminul Haque AU - Mackova, H AU - Horak, D AU - Fodorné Kardos, Andrea AU - Tóth, Judit AU - Gyenis, János AU - Feczkó, Tivadar TI - Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery JF - E-POLYMERS J2 - E-POLYMERS VL - 13 PY - 2013 IS - 1 SP - 310 EP - 318 PG - 9 SN - 1618-7229 DO - 10.1515/epoly.2013.13.1.310 UR - https://m2.mtmt.hu/api/publication/2417666 ID - 2417666 LA - English DB - MTMT ER - TY - JOUR AU - Socol, G AU - Preda, N AU - Socol, M AU - Sima, L AU - Luculescu, CR AU - Sima, F AU - Miroiu, M AU - Axente, E AU - Visan, A AU - Stefan, N AU - Cristescu, R AU - Dorcioman, G AU - Stanculescu, A AU - Radulescu, L AU - Mihailescu, IN TI - MAPLE DEPOSITION OF PLGA MICRO- AND NANOPARTICLES EMBEDDED INTO POLYMERIC COATINGS JF - DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES J2 - DIG J NANOMATER BIOS VL - 8 PY - 2013 IS - 2 SP - 621 EP - 630 PG - 10 SN - 1842-3582 UR - https://m2.mtmt.hu/api/publication/23285779 ID - 23285779 N1 - National Institute for Lasers, Plasma and Radiation Physics, Magurele, Ilfov, Romania National Institute of Materials Physics, Magurele, Ilfov, Romania Institute of Biochemistry, Splaiul Independentei 296, Bucharest, Romania Institute of Cellular Biology and Pathology N. Simionescu, Bucharest, Romania Cited By :7 Export Date: 21 February 2022 Correspondence Address: Socol, G.; National Institute for Lasers, , Magurele, Ilfov, Romania; email: gabriel.socol@inflpr.ro LA - English DB - MTMT ER - TY - JOUR AU - Kapse, SV AU - Gaikwad, RV AU - Samad, A AU - Devarajan, PV TI - Self nanoprecipitating preconcentrate of tamoxifen citrate for enhanced bioavailability JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 429 PY - 2012 IS - 1-2 SP - 104 EP - 112 PG - 9 SN - 0378-5173 DO - 10.1016/j.ijpharm.2012.02.042 UR - https://m2.mtmt.hu/api/publication/22351193 ID - 22351193 N1 - Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai 400 019, India Veterinary Nuclear Medicine Center, Department of Medicine, Bombay Veterinary College, Parel, Mumbai 400 012, India Cited By :17 Export Date: 21 February 2022 CODEN: IJPHD Correspondence Address: Devarajan, P.V.; Department of Pharmaceutical Sciences and Technology, , Matunga, Mumbai 400 019, India; email: pvdevarajan@gmail.com Chemicals/CAS: polysorbate 80, 8050-83-7, 9005-65-6; povidone, 9003-39-8; tamoxifen citrate, 54965-24-1; technetium 99m, 14133-76-7; Antineoplastic Agents, Hormonal; Dioctyl Sulfosuccinic Acid, 10041-19-7; Polysorbates; Povidone, 9003-39-8; Surface-Active Agents; Tamoxifen, 10540-29-1 Manufacturers: ar ex, India; Uniqema, India Funding text 1: Sonali V. Kapse acknowledges University Grant Commission (UGC), Government of India for providing Senior Research Fellowship. Authors wish to acknowledge Tata Institute of Fundamental Research (TIFR) (Mumbai-India) for XRD study and Perkin Elmer Pvt. Ltd (Mumbai, India) for FTIR microscopy and Imaging. LA - English DB - MTMT ER - TY - JOUR AU - Kreidel, RN AU - Duque, MD AU - Serra, CHR AU - Velasco, MVR AU - Baby, AR AU - Kaneko, TM AU - Consiglieri, VO TI - Dissolution Enhancement and Characterization of Nimodipine Solid Dispersions with Poloxamer 407 or PEG 6000 JF - JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY J2 - J DISPER SCI TECHNOL VL - 33 PY - 2012 IS - 9 SP - 1354 EP - 1359 PG - 6 SN - 0193-2691 DO - 10.1080/01932691.2011.605663 UR - https://m2.mtmt.hu/api/publication/22781129 ID - 22781129 N1 - Cited By :13 Export Date: 21 February 2022 Correspondence Address: Kreidel, R. N.; Pharmacy Department, Av. Lineu Prestes, 580, Bloco 13, Cidade Universitaria, 05508-900, São Paulo, SP, Brazil; email: rogerio.kreidel@usp.br LA - English DB - MTMT ER - TY - JOUR AU - Liu, J AU - Xu, L AU - Liu, C AU - Zhang, D AU - Wang, S AU - Deng, Z AU - Lou, W AU - Xu, H AU - Bai, Q AU - Ma, J TI - Preparation and characterization of cationic curcumin nanoparticles for improvement of cellular uptake JF - CARBOHYDRATE POLYMERS J2 - CARBOHYD POLYM VL - 90 PY - 2012 IS - 1 SP - 16 EP - 22 PG - 7 SN - 0144-8617 DO - 10.1016/j.carbpol.2012.04.036 UR - https://m2.mtmt.hu/api/publication/22516696 ID - 22516696 N1 - Department of Prosthodontics, School and Hospital of Stomatology, Whenzhou Medical College, 113 Xueyuan Road, Whenzhou 325027, China Department of General Medicine, First Affiliated Hospital, Whenzhou Medical College, Whenzhou 325000, China Cited By :83 Export Date: 21 February 2022 CODEN: CAPOD Correspondence Address: Ma, J.; Department of Prosthodontics, 113 Xueyuan Road, Whenzhou 325027, China; email: dragonlve@163.com Chemicals/CAS: chitosan, 9012-76-4; curcumin, 458-37-7; polycaprolactone, 24980-41-4, 25248-42-4; Antineoplastic Agents; Cations; Chitosan; Curcumin; Delayed-Action Preparations; polycaprolactone; Polyesters Funding details: 2011R413003 Funding details: National Cancer Institute, NCI, P50CA083639 Funding details: Natural Science Foundation of Zhejiang Province, ZJNSF, Y12H140011 Funding text 1: This work was supported by Nature Science Foundation of Zhejiang Province (grant number Y12H140011 ) and Undergraduate Scientific and Technological Innovation Project of Zhengjiang Province (grant number 2011R413003 ). LA - English DB - MTMT ER - TY - JOUR AU - Locatelli, E AU - Franchini, MC TI - Biodegradable PLGA-b-PEG polymeric nanoparticles: Synthesis, properties, and nanomedical applications as drug delivery system JF - JOURNAL OF NANOPARTICLE RESEARCH J2 - J NANOPART RES VL - 14 PY - 2012 IS - 12 SN - 1388-0764 DO - 10.1007/s11051-012-1316-4 UR - https://m2.mtmt.hu/api/publication/22854857 ID - 22854857 N1 - Cited By :132 Export Date: 21 February 2022 Correspondence Address: Franchini, M.C.; Dipartimento di Chimica Industriale Toso Montanari, Viale Risorgimento 4, 40136 Bologna, Italy; email: mauro.comesfranchini@unibo.it Chemicals/CAS: macrogol, 25322-68-3; polyglactin, 26780-50-7, 34346-01-5 Funding details: Seventh Framework Programme, FP7, 263307 Funding text 1: Acknowledgments This work was supported by the funding of EU-FP7 European project Save Me (contract no. CP-IP 263307-2). LA - English DB - MTMT ER - TY - JOUR AU - Scala-Bertola, J AU - Javot, L AU - Camargo, JA AU - Bonneaux, F AU - Lecompte, T AU - Maincent, P AU - Sapin, A TI - Evaluation of subcutaneous forms in the improvement of pharmacokinetic profile of warfarin JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 431 PY - 2012 IS - 1-2 SP - 33 EP - 38 PG - 6 SN - 0378-5173 DO - 10.1016/j.ijpharm.2012.03.053 UR - https://m2.mtmt.hu/api/publication/22386236 ID - 22386236 N1 - Nancy-Université, Faculty of Pharmacy, Laboratory of Pharmaceutical Technology, 5 rue A.Lebrun, 54001 Nancy Cedex, France CHU de Nancy, Nancy-Université, Federation de Recherche Bioingenierie Moleculaire, Cellulaire et Therapeutique, Nancy, France Cited By :3 Export Date: 21 February 2022 CODEN: IJPHD Correspondence Address: Maincent, P.; Nancy-Université, 5 rue A.Lebrun, 54001 Nancy Cedex, France; email: philippe.maincent@pharma.uhp-nancy.fr Chemicals/CAS: polycaprolactone, 24980-41-4, 25248-42-4; prothrombin, 9001-26-7; warfarin, 129-06-6, 2610-86-8, 3324-63-8, 5543-58-8, 81-81-2; Anticoagulants; Delayed-Action Preparations; Polyesters; Povidone, 9003-39-8; Suspensions; Warfarin, 81-81-2; polycaprolactone, 24980-41-4 LA - English DB - MTMT ER - TY - JOUR AU - Shau, Min Da AU - Shih, Mei Fen AU - Lin, Chi Cheng AU - et, al TI - A one-step process in preparation of cationic nanoparticles with poly(lactide-co-glycolide)-containing polyethylenimine gives efficient gene delivery JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - EUR J PHARM SCI VL - 46 PY - 2012 IS - 5 SP - 522 EP - 529 PG - 8 SN - 0928-0987 DO - 10.1016/j.ejps.2012.04.006 UR - https://m2.mtmt.hu/api/publication/22516751 ID - 22516751 N1 - Department of Biotechnology, Chia-Nan University of Pharmacy and Science, 60 Erh-Jen Rd., Jen-Te, Taiwan Department of Pharmacy, Chia-Nan University of Pharmacy and Science, 60 Erh-Jen Rd., Jen-Te, Taiwan Department of Chemistry and Biochemistry, National Chung Cheng University, 168 University Rd., Chia-yi 621, Taiwan Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, Netherlands Cited By :27 Export Date: 21 February 2022 CODEN: EPSCE Correspondence Address: Cherng, J.Y.; Department of Chemistry and Biochemistry, 168 University Rd., Chia-yi 621, Taiwan; email: jycherng@yahoo.com Chemicals/CAS: acetic acid ethyl ester, 141-78-6; polyethyleneimine, 74913-72-7; polyglactin, 26780-50-7, 34346-01-5; Acetates; Cations; DNA, 9007-49-2; Green Fluorescent Proteins, 147336-22-9; Polyethyleneimine, 9002-98-6; Polyglactin 910, 34346-01-5; Polyvinyl Alcohol, 9002-89-5; beta-Galactosidase, 3.2.1.23; enhanced green fluorescent protein; ethyl acetate, 141-78-6 LA - English DB - MTMT ER - TY - JOUR AU - Silva, R AU - Ferreira, H AU - Carvalho, AC AU - Gomes, AC AU - Cavaco-Paulo, A TI - Protein microspheres as suitable devices for piroxicam release JF - COLLOIDS AND SURFACES B: BIOINTERFACES J2 - COLLOID SURFACE B VL - 92 PY - 2012 SP - 277 EP - 285 PG - 9 SN - 0927-7765 DO - 10.1016/j.colsurfb.2011.11.050 UR - https://m2.mtmt.hu/api/publication/22268607 ID - 22268607 N1 - University of Minho, Department of Textile Engineering, Campus de Azurém, 4800-058 Guimarães, Portugal CBMA (Centre of Molecular and Environmental Biology), Department of Biology, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal CICS, Health Sciences Research Sciences, Department of Pharmaceutical Sciences, Rua Central de Gandra, 1317, 4585-116 Gandra-PRD, Portugal Cited By :26 Export Date: 21 February 2022 CODEN: CSBBE Correspondence Address: Cavaco-Paulo, A.; University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal; email: artur@det.uminho.pt Chemicals/CAS: human serum albumin, 9048-49-1; piroxicam, 36322-90-4; polyvinyl alcohol, 37380-95-3, 9002-89-5; Piroxicam, 36322-90-4; Polyvinyl Alcohol, 9002-89-5; Serum Albumin; Serum Albumin, Bovine Manufacturers: Sigma, Spain Funding details: Fundação para a Ciência e a Tecnologia, FCT, SFRH/BPD/38939/2007 Funding text 1: We would like to acknowledge the financial support of European project Lidwine (contract no. NMP2-CT-2006-026741), and to POPH/FSE for co-financing and FCT for fellowship SFRH/BPD/38939/2007. LA - English DB - MTMT ER - TY - JOUR AU - Brunner, CT AU - Baran, ET AU - Pinho, ED AU - Reis, RL AU - Neves, NM TI - Performance of biodegradable microcapsules of poly(butylene succinate), poly(butylene succinate-co-adipate) and poly(butylene terephthalate-co-adipate) as drug encapsulation systems JF - COLLOIDS AND SURFACES B: BIOINTERFACES J2 - COLLOID SURFACE B VL - 84 PY - 2011 IS - 2 SP - 498 EP - 507 PG - 10 SN - 0927-7765 DO - 10.1016/j.colsurfb.2011.02.005 UR - https://m2.mtmt.hu/api/publication/21521719 ID - 21521719 N1 - 3B's Research Group - Biomaterials and Biodegradables and Biomimetics, University of Minho and Regenerative Medicine and S. Cláudio do Barco, Headquarters of the European Institute of Excellence on Tissue Engineering, AvePark, 4806-909 Taipas, Guimarães, Portugal IBB - Institute for Biotechnology and Bioengineering, PT Government Associated Laboratory, Guimarães, Portugal Department of Engineering Sciences, Martin-Luther University Halle-Wittenberg, D-06099 Halle/S, Germany Cited By :37 Export Date: 21 February 2022 CODEN: CSBBE Correspondence Address: Brunner, C.T.; 3B's Research Group - Biomaterials and Biodegradables and Biomimetics, AvePark, 4806-909 Taipas, Guimarães, Portugal; email: corneliabrunner@gmail.com Chemicals/CAS: polyvinyl alcohol, 37380-95-3, 9002-89-5; retinoic acid, 302-79-4; Adipic Acids; Butylene Glycols; Capsules; Delayed-Action Preparations; Polyesters; Polymers; Serum Albumin, Bovine; Succinates; Tretinoin, 302-79-4; bionole; poly(butylene adipate-co-butylene terephthalate); poly(butylene succinate-co-butylene adipate) Funding details: Interreg Funding text 1: This work was supported by INTERREG III A project PROTEUS – conversion of natural marine resources and residues into high added value products for industrial application. LA - English DB - MTMT ER - TY - JOUR AU - Feczkó, Tivadar AU - Tóth, Judit AU - Dósa, György AU - Gyenis, János TI - Influence of process conditions on the mean size of PLGA nanoparticles JF - CHEMICAL ENGINEERING AND PROCESSING J2 - CHEM ENG PROCESS VL - 50 PY - 2011 IS - 8 SP - 846 EP - 853 PG - 8 SN - 0255-2701 DO - 10.1016/j.cep.2011.05.006 UR - https://m2.mtmt.hu/api/publication/1671122 ID - 1671122 N1 - Research Institute of Chemical and Process Engineering, Faculty of Information Technology, University of Pannonia, Egyetem u. 2H-8200 Veszprem, Hungary Institute of Materials and Environmental Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri u. 59-67, H-1025 Budapest, Hungary Department of Mathematics, Faculty of Information Technology, University of Pannonia, Egyetem u. 2H-8200 Veszprem, Hungary Cited By :43 Export Date: 15 November 2019 CODEN: CENPE Correspondence Address: Gyenis, J.; Research Institute of Chemical and Process Engineering, Faculty of Information Technology, University of Pannonia, Egyetem u. 2H-8200 Veszprem, Hungary; email: gyenis@mukki.richem.hu Funding details: -2004-05-0031/3.0 Funding text 1: The authors gratefully acknowledge the financial support of the Hungarian National Office for Research and Technology (Grant No. GVOP-3.1.1.-2004-05-0031/3.0 ), and the support of the Central Trans-Danubian Regional Development Agency provided to develop our particle analysis laboratory (Grant No. BAROSS-5-2007-0006 ). Appendix A WoS:hiba:000295504600016 2019-12-06 05:56 cím nem egyezik LA - English DB - MTMT ER - TY - JOUR AU - Feczkó, Tivadar AU - Tóth, Judit AU - Dósa, György AU - Gyenis, János TI - Optimization of protein encapsulation in PLGA nanoparticles JF - CHEMICAL ENGINEERING AND PROCESSING J2 - CHEM ENG PROCESS VL - 50 PY - 2011 IS - 8 SP - 757 EP - 765 PG - 9 SN - 0255-2701 DO - 10.1016/j.cep.2011.06.008 UR - https://m2.mtmt.hu/api/publication/1671149 ID - 1671149 N1 - Megjegyzés-21721495 : FN Thomson Reuters Web of Knowledge Megjegyzés-21699882 : FN Thomson Reuters Web of Knowledge LA - English DB - MTMT ER - TY - JOUR AU - Geay, F AU - Ferraresso, S AU - Zambonino-Infante, JL AU - Bargelloni, L AU - Quentel, C AU - Vandeputte, M AU - Kaushik, S AU - Cahu, CL AU - Mazurais, D TI - Effects of the total replacement of fish-based diet with plant-based diet on the hepatic transcriptome of two European sea bass (Dicentrarchus labrax) half-sibfamilies showing different growth rates with the plant-based diet JF - BMC GENOMICS J2 - BMC GENOMICS VL - 12 PY - 2011 SN - 1471-2164 DO - 10.1186/1471-2164-12-522 UR - https://m2.mtmt.hu/api/publication/21803162 ID - 21803162 N1 - : FN Thomson Reuters Web of Knowledge Megjegyzés-21782236 : FN Thomson Reuters Web of Knowledge WC: Biotechnology & Applied Microbiology; Genetics & Heredity LA - English DB - MTMT ER - TY - JOUR AU - Rothstein, SN AU - Little, SR TI - A "tool box" for rational design of degradable controlled release formulations JF - JOURNAL OF MATERIALS CHEMISTRY J2 - J MATER CHEM VL - 21 PY - 2011 IS - 1 SP - 29 EP - 39 PG - 11 SN - 0959-9428 DO - 10.1039/c0jm01668c UR - https://m2.mtmt.hu/api/publication/21521688 ID - 21521688 N1 - Department of Chemical Engineering, University of Pittsburgh, PA, United States McGowan Institute for Regenerative Medicine, University of Pittsburgh, PA, United States Department of Bioengineering, University of Pittsburgh, PA, United States Department of Immunology, University of Pittsburgh, PA, United States Benedum Hall Room 1249, 3700 O'Hara Street, Pittsburgh, PA 15261, United States Cited By :41 Export Date: 21 February 2022 CODEN: JMACE Correspondence Address: Little, S. R.; Department of Chemical Engineering, , PA, United States; email: srlittle@pitt.edu LA - English DB - MTMT ER - TY - JOUR AU - Silva, R AU - Ferreira, H AU - Cavaco-Paulo, A TI - Sonoproduction of Liposomes and Protein Particles as Templates for Delivery Purposes JF - BIOMACROMOLECULES J2 - BIOMACROMOLECULES VL - 12 PY - 2011 IS - 10 SP - 3353 EP - 3368 PG - 16 SN - 1525-7797 DO - 10.1021/bm200658b UR - https://m2.mtmt.hu/api/publication/21713474 ID - 21713474 N1 - Department of Textile Engineering, Campus de Azurém, University of Minho, 4800-058, Guimarães, Portugal Health Sciences Research Sciences, Department of Pharmaceutical Sciences, CICS, Rua Central de Gandra, 1317, 4585-116 Gandra-PRD, Portugal Cited By :35 Export Date: 21 February 2022 CODEN: BOMAF Correspondence Address: Cavaco-Paulo, A.; Department of Textile Engineering, , 4800-058, Guimarães, Portugal Chemicals/CAS: casein, 9000-71-9; collagen, 9007-34-5; cysteine, 4371-52-2, 52-89-1, 52-90-4; dimyristoylphosphatidylcholine, 13699-48-4, 18194-24-6; dipalmitoylphosphatidylcholine, 2644-64-6; gelatin, 9000-70-8; gemcitabine, 103882-84-4; human serum albumin, 9048-49-1; paclitaxel, 33069-62-4; phosphatidylcholine, 55128-59-1, 8002-43-5; piroxicam, 36322-90-4; protein, 67254-75-5; tetracycline, 23843-90-5, 60-54-8, 64-75-5, 8021-86-1; Biocompatible Materials; Delayed-Action Preparations; Dendrimers; Liposomes; Proteins Tradenames: gemzar; taxol LA - English DB - MTMT ER - TY - JOUR AU - Valentová, E AU - Snejdrová, E AU - Dittrich, M TI - The influence of PVA on the size of oligoester anoparticles prepared by the emulsion solvent distribution method JF - CESKA A SLOVENSKA FARMACIE J2 - CESKA A SLOVENSKA FARMACIE VL - 60 PY - 2011 IS - 4 SP - 193 EP - 199 PG - 7 SN - 1210-7816 UR - https://m2.mtmt.hu/api/publication/22516670 ID - 22516670 N1 - Export Date: 21 February 2022 CODEN: CSLFE Correspondence Address: Valentová, E.M. Majerové 283, 533 53 Pardubice, Czech Republic; email: valentova.eva@seznam.cz Chemicals/CAS: dichloromethane, 75-09-2; polyvinyl alcohol, 37380-95-3, 9002-89-5 LA - English DB - MTMT ER - TY - JOUR AU - Vijayaragavan, S AU - Vino, S AU - Lokesh, K R AU - Ghosh, A R AU - Jayaraman, G TI - Controlled release of methotrexate using alpha-lactalbumin microparticles VL - 381 PY - 2011 SP - 39 EP - 44 PG - 6 UR - https://m2.mtmt.hu/api/publication/22516688 ID - 22516688 LA - English DB - MTMT ER - TY - JOUR AU - Vijayaragavan, S. AU - Vino, S. AU - Lokesh, K.R. AU - Ghosh, A.R. AU - Jayaraman, G. TI - Controlled release of methotrexate using alpha-lactalbumin microparticles JF - JOURNAL OF INTERNATIONAL PHARMACEUTICAL RESEARCH J2 - J INT PHARMACEUT RES VL - 3 PY - 2011 IS - 1 SP - 39 EP - 44 PG - 6 SN - 1674-0440 UR - https://m2.mtmt.hu/api/publication/32694101 ID - 32694101 N1 - Cited By :1 Export Date: 21 February 2022 Correspondence Address: Jayaraman, G.; School of Bio Sciences and Technology, , Vellore, India; email: gjayaraman@vit.ac.in Chemicals/CAS: alpha lactalbumin, 9051-29-0; chloroform, 67-66-3; ethyl cellulose, 9004-57-3; glutaraldehyde, 111-30-8, 37245-61-7; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; water, 7732-18-5 Manufacturers: Cipla, India AB - Microparticles of α -lactalbumin, in the free and methotrexate encapsulated forms were prepared by emulsifying an aqueous solution of α -lactalbumin in 1% ethylcellulose in chloroform at 4°C. The particles were further stabilized by cross linking with glutaraldehyde. The size of the particles was found to be in the range of 0.5 to 2μm, with an average size of 1 μm. Both free and methotrexate encapsulated α -lactalbumin microparticles were analyzed by differential scanning calorimetry and X-ray diffraction studies. The rate of drug release was investigated by in vitro dissolution studies using UV spectroscopy. The results indicate that these α -lactalbumin microparticles are capable of controlled and sustained release of methotrexate up to a maximum time of 36 h in PBS at pH 7.4. The study introduces α -lactalbumin as a novel drug carrier and its potential to combat the failure of free methotrexate administration. LA - English DB - MTMT ER - TY - JOUR AU - Wang, M -B AU - Feng, Q -L AU - She, Z -D AU - Tan, R -W TI - Latest research progress of drug stability and release of PLGA microspheres JF - JOURNAL OF FUNCTIONAL MATERIALS J2 - J OF FUNCTIONAL METERIALS VL - 42 PY - 2011 IS - 4 SP - 591 EP - 595 PG - 5 SN - 1001-9731 UR - https://m2.mtmt.hu/api/publication/22516672 ID - 22516672 N1 - Department of Materials Science and Engineering, Laboratory of Advanced Materials, Tsinghua University, Beijing 100084, China Center for Advanced Materials and Biotechnology, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China Export Date: 21 February 2022 CODEN: GOCAE Correspondence Address: Feng, Q.-L.; Department of Materials Science and Engineering, , Beijing 100084, China LA - English DB - MTMT ER - TY - JOUR AU - Wieber, A AU - Selzer, T AU - Kreuter, J TI - Characterisation and stability studies of a hydrophilic decapeptide in different adjuvant drug delivery systems: A comparative study of PLGA nanoparticles versus chitosan-dextran sulphate microparticles versus DOTAP-liposomes JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 421 PY - 2011 IS - 1 SP - 151 EP - 159 PG - 9 SN - 0378-5173 DO - 10.1016/j.ijpharm.2011.09.011 UR - https://m2.mtmt.hu/api/publication/21782011 ID - 21782011 N1 - : FN Thomson Reuters Web of Knowledge WC: Pharmacology & Pharmacy LA - English DB - MTMT ER - TY - JOUR AU - Ying, XG AU - Cheng, GX AU - Li, X TI - The Imprinting Induce-Fit Model of Specific Rebinding of Macromolecularly Imprinted Polymer Microspheres JF - JOURNAL OF APPLIED POLYMER SCIENCE J2 - J APPL POLYM SCI VL - 122 PY - 2011 IS - 3 SP - 1847 EP - 1856 PG - 10 SN - 0021-8995 DO - 10.1002/app.34263 UR - https://m2.mtmt.hu/api/publication/21713473 ID - 21713473 N1 - : FN Thomson Reuters Web of Knowledge LA - English DB - MTMT ER - TY - CHAP AU - Feczkó, Tivadar ED - Fanun, M TI - Multiple emulsion - Solvent evaporation technique T2 - Colloids in Biotechnology PB - CRC Press - Taylor and Francis Group CY - Boca Raton, Florida SN - 9781439830802 PY - 2010 SP - 349 EP - 380 PG - 32 DO - 10.1201/EBK1439830802 UR - https://m2.mtmt.hu/api/publication/1400917 ID - 1400917 N1 - [4.1] LA - English DB - MTMT ER - TY - JOUR AU - Feczkó, Tivadar AU - Kohol, V AU - Voncina, B TI - Preparation and characterization of ethylcellulose-based microcapsules for sustaining release of a model fragrance JF - MACROMOLECULAR RESEARCH J2 - MACROMOL RES VL - 18 PY - 2010 IS - 7 SP - 636 EP - 640 PG - 5 SN - 1598-5032 DO - 10.1007/s13233-010-0701-z UR - https://m2.mtmt.hu/api/publication/1377417 ID - 1377417 N1 - [4.1] LA - English DB - MTMT ER - TY - JOUR AU - Manchanda, R AU - Fernandez-Fernandez, A AU - Nagesetti, A AU - McGoron, A J TI - Preparation and characterization of a polymeric (PLGA) nanoparticulate drug delivery system with simultaneous incorporation of chemotherapeutic and thermo-optical agents JF - COLLOIDS AND SURFACES B: BIOINTERFACES J2 - COLLOID SURFACE B VL - 75 PY - 2010 IS - 1 SP - 260 EP - 267 PG - 8 SN - 0927-7765 UR - https://m2.mtmt.hu/api/publication/20914287 ID - 20914287 LA - English DB - MTMT ER - TY - JOUR AU - Ratzinger, G AU - Langer, U AU - Neutsch, L AU - et, al TI - Surface Modification of PLGA Particles: The Interplay between Stabilizer, Ligand Size, and Hydrophobic Interactions JF - LANGMUIR J2 - LANGMUIR VL - 26 PY - 2010 IS - 3 SP - 1855 EP - 1859 PG - 5 SN - 0743-7463 DO - 10.1021/la902602z UR - https://m2.mtmt.hu/api/publication/20914283 ID - 20914283 N1 - Department of Pharmaceutical Technology and Biopliarmaceuties, Faculty of Life Sciences, University of Vienna, Vienna, Austria Department of Biochemistry, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria Cited By :16 Export Date: 21 February 2022 CODEN: LANGD Correspondence Address: Gabor, F.Althanstrasse 14, A-1090, Vienna, Austria; email: franz.gabor@univie.ac.at Chemicals/CAS: cadaverine, 1476-39-7, 462-94-2; fluorescein, 2321-07-5, 91316-42-6; immunoglobulin G, 97794-27-9; poloxamer, 9003-11-6; polyglactin, 26780-50-7, 34346-01-5; Cadaverine, 462-94-2; Fluorescein, 2321-07-5; Fluorescent Dyes; Immobilized Proteins; Immunoglobulin G; Ligands; Poloxamer, 106392-12-5; Polyglactin 910, 34346-01-5 LA - English DB - MTMT ER - TY - JOUR AU - Belic, A TI - Modelling in systems biology, neurology and pharmacy JF - MATHEMATICAL AND COMPUTER MODELLING OF DYNAMICAL SYSTEMS J2 - MATH COMP MODEL DYN VL - 15 PY - 2009 IS - 6 SP - 479 EP - 491 PG - 13 SN - 1387-3954 DO - 10.1080/13873950903375304 UR - https://m2.mtmt.hu/api/publication/21803163 ID - 21803163 LA - English DB - MTMT ER - TY - JOUR AU - Huang, Q-P AU - Wang, J-X AU - Zhang, Z-B AU - Shen, Z-G AU - Chen, J-F AU - Yun, J TI - Preparation of ultrafine fenofibrate powder by solidification process from emulsion JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 368 PY - 2009 IS - 1-2 SP - 160 EP - 164 PG - 5 SN - 0378-5173 DO - 10.1016/j.ijpharm.2008.10.015 UR - https://m2.mtmt.hu/api/publication/20507620 ID - 20507620 N1 - Sin-China Nano Technology Center, Key Lab for Nanomaterials, Ministry of Education, Beijing, 100029, China Nanomaterials Technology Pte. Ltd., 28 Ayer Rajah Crescent #03-03, Singapore, 139959, Singapore Cited By :21 Export Date: 21 February 2022 CODEN: IJPHD Correspondence Address: Chen, J.-F.; Sin-China Nano Technology Center, , Beijing, 100029, China; email: chenjf@mail.buct.edu.cn Chemicals/CAS: fenofibrate, 49562-28-9; water, 7732-18-5; Antilipemic Agents; Emulsifying Agents; Emulsions; Powders; Procetofen, 49562-28-9; Water, 7732-18-5 Manufacturers: Zhejiang Excel Pharmaceutical, China Funding details: 2006AA030202 Funding details: National Natural Science Foundation of China, NSFC, 20806004 Funding text 1: This work was financially supported by National Natural Science Foundation of China (No. 20806004) and National “863” Program of China (Grant No. 2006AA030202). LA - English DB - MTMT ER - TY - THES AU - Mallepally, R R TI - Encapsulation and Controlled Release of Pharmaceuticals with biodegradable Hyperbranched Polyesters PY - 2009 UR - https://m2.mtmt.hu/api/publication/22516555 ID - 22516555 LA - English DB - MTMT ER - TY - GEN AU - Rahimnejad, M AU - Najafpour, G AU - Jahanshahi, M TI - Evaluation of effective parameters on fabrication of BSA nanoparticles. Nature Precedings TS - Nature Precedings PY - 2009 UR - https://m2.mtmt.hu/api/publication/22516643 ID - 22516643 LA - English DB - MTMT ER - TY - JOUR AU - Stevanovic, M AU - Uskokovic, D TI - Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins JF - CURRENT NANOSCIENCE J2 - CURR NANOSCI VL - 5 PY - 2009 IS - 1 SP - 1 EP - 14 PG - 14 SN - 1573-4137 DO - 10.2174/157341309787314566 UR - https://m2.mtmt.hu/api/publication/20914279 ID - 20914279 N1 - Cited By :125 Export Date: 21 February 2022 Correspondence Address: Stevanović, M.; Institute of Technical Sciences, Knez Mihailova 35AV, 11000 Belgrade, Serbia; email: magdalena@itn.sanu.ac.yu Chemicals/CAS: alendronic acid, 66376-36-1; carbomer, 9007-20-9, 9062-04-8; etanidazole, 22668-01-5; folic acid, 59-30-3, 6484-89-5; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; paclitaxel, 33069-62-4; poloxamer, 9003-11-6; polyglactin, 26780-50-7, 34346-01-5; polyglycolide, 26009-03-0, 26202-08-4; polylactide, 26680-10-4; polyvinyl alcohol, 37380-95-3, 9002-89-5; povidone, 9003-39-8; protein, 67254-75-5 LA - English DB - MTMT ER - TY - JOUR AU - Juvan, P AU - Rezen, T AU - Rozman, D AU - Monostory, K AU - Pascussi, J AU - Belic, A TI - Towards Identification of Gene Interaction Networks of Human Cholesterol Biosynthesis (vol 55, pg 396, 2008) JF - ACTA CHIMICA SLOVENICA J2 - ACTA CHIM SLOV VL - 55 PY - 2008 IS - 3 SP - 688 EP - 688 PG - 1 SN - 1318-0207 UR - https://m2.mtmt.hu/api/publication/21803164 ID - 21803164 LA - English DB - MTMT ER - TY - JOUR AU - Ling, Y AU - Huang, Y-S AU - Liang, C-Y AU - Li, X-M TI - Preparation and characterization of folate-mediated poly (lactic-co-glycolic) acid nanoparticles VL - 12 PY - 2008 IS - 36 SP - 7049 EP - 7052 UR - https://m2.mtmt.hu/api/publication/20913982 ID - 20913982 LA - English DB - MTMT ER - TY - JOUR AU - Ling, Y AU - Huang, Y-S AU - Liang, C-Y TI - Research progress in poly (lactic-co-glycolic acid) nanoparticles VL - 12 PY - 2008 IS - 10 SP - 1899 EP - 1902 UR - https://m2.mtmt.hu/api/publication/20913977 ID - 20913977 LA - English DB - MTMT ER -