@article{MTMT:34585988, title = {Controlling the Synthesis of Polyurea Microcapsules and the Encapsulation of Active Diisocyanate Compounds}, url = {https://m2.mtmt.hu/api/publication/34585988}, author = {Avdeliodi, Efterpi and Tsioli, Anastasia and Bokias, Georgios and Kallitsis, Joannis K.}, doi = {10.3390/polym16020270}, journal-iso = {POLYMERS-BASEL}, journal = {POLYMERS}, volume = {16}, unique-id = {34585988}, abstract = {The encapsulation of active components is currently used as common methodology for the insertion of additional functions like self-healing properties on a polymeric matrix. Among the different approaches, polyurea microcapsules are used in different applications. The design of polyurea microcapsules (MCs) containing active diisocyanate compounds, namely isophorone diisocyanate (IPDI) or hexamethylene diisocyanate (HDI), is explored in the present work. The polyurea shell of MCs is formed through the interfacial polymerization of oil-in-water emulsions between the highly active methylene diphenyl diisocyanate (MDI) and diethylenetriamine (DETA), while the cores of MCs contain, apart from IPDI or HDI, a liquid Novolac resin. The hydroxyl functionalities of the resin were either unprotected (Novolac resin), partially protected (Benzyl Novolac resin) or fully protected (Acetyl Novolac resin). It has been found that the formation of MCs is controlled by the MDI/DETA ratio, while the shape and size of MCs depends on the homogenization rate applied for emulsification. The encapsulated active compound, as determined through the titration of isocyanate (NCO) groups, was found to decrease with the hydroxyl functionality content of the Novolac resin used, indicating a reaction between NCO and the hydroxyl groups. Through the thorough investigation of the organic phase, the rapid reaction (within a few minutes) of MDI with the unprotected Novolac resin was revealed, while a gradual decrease in the NCO groups (within two months) has been observed through the evolution of the Attenuated Total Reflectance-Fourier-Transform Infrared (ATR-FTIR) spectroscopy and titration, due to the reaction of these groups with the hydroxyl functionalities of unprotected and partially protected Novolac resin. Over longer times (above two months), the reaction of the remaining NCO groups with humidity was evidenced, especially when the fully protected Acetyl Novolac resin was used. HDI was found to be more susceptible to reactions, as compared with IPDI.}, keywords = {Microcapsules; Hexamethylene diisocyanate; Isophorone diisocyanate; Novolac resin; NCO-compounds}, year = {2024}, eissn = {2073-4360}, orcid-numbers = {Bokias, Georgios/0000-0003-0893-4716} } @article{MTMT:34242731, title = {Pomegranate nanoparticle mitigates cisplatin-induced testicular toxicity and improves cisplatin anti-cancer efficacy in Ehrlich carcinoma model}, url = {https://m2.mtmt.hu/api/publication/34242731}, author = {Qari, Mohammed and Harakeh, Steve and Akefe, Isaac O. and Saber, Saber H. and Al-Raddadi, Rajaa and Abd Elmageed, Zakaria Y. and Alamri, Turki and El-Shitany, Nagla and Ali, Soad S. and Almuhayawi, Mohammed S. and Mousa, Shaker}, doi = {10.1016/j.jksus.2023.102631}, journal-iso = {J KING SAUD UNIV SCI}, journal = {JOURNAL OF KING SAUD UNIVERSITY - SCIENCE}, volume = {35}, unique-id = {34242731}, issn = {1018-3647}, abstract = {Cisplatin (CISP) ranks among the most used chemo-therapeutic agents with exceptional efficacy against testicular cancer among other diverse types of cancers. However, it has been associated with nephrotox-icity among other side effects. Pomegranate (PE) is an effective anti-inflammatory and antioxidant com-pound, protecting against several chemotherapy-linked toxicities. The use of PE are limited due to its low bioavailability and poor solubility. We investigated the potential of a novel nanoparticle (NP) encapsulat-ing PE formulation to surmount its poor solubility, improve its bioavailability, and augment its protective efficacy against CISP-induced testicular toxicity in an Ehrlich solid carcinoma (ESC) mice model. All ani-mals were randomly grouped into four treatment groups: 1) control, 2) tumor, 3) CISP, and 4) CISP + PE -NPs. The results obtained demonstrated that PE-NPs efficiently prevented testicular toxicity induced by CISP in ESC mice and enhanced its functions. PE-NPs effectively improved CISP-induced oxidative stress in testicular tissues by elevating the levels of antioxidants (GSH, SOD and CAT). Importantly, PE-NPs, also, substantially decreased testicular inflammation induced by CISP, via reducing the levels of IL-1b, TNF-a, and NF-kB. PE-NPs did not impede the CISP's antitumor activity as shown by histological examination data and tumor weight. It is, therefore, conceivable that PE-NPs may serve as an adjuvant therapy to CISP in the treatment of cancer, to ameliorate the associated testicular toxicity and other unwanted effects without compromising the antitumor efficacy of CISP.& COPY; 2023 Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).}, keywords = {cisplatin; anti-inflammatory; pomegranate; Testicular toxicity; Ehrlich; Nano formulation}, year = {2023}, eissn = {2213-686X}, orcid-numbers = {El-Shitany, Nagla/0000-0003-2593-6879} } @article{MTMT:32942871, title = {Effect of Solvents, Stabilizers and the Concentration of Stabilizers on the Physical Properties of Poly(d,l-lactide-co-glycolide) Nanoparticles: Encapsulation, In Vitro Release of Indomethacin and Cytotoxicity against HepG2-Cell}, url = {https://m2.mtmt.hu/api/publication/32942871}, author = {Alkholief, Musaed and Abul Kalam, Mohd and Anwer, Md Khalid and Alshamsan, Aws}, doi = {10.3390/pharmaceutics14040870}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {14}, unique-id = {32942871}, issn = {1999-4923}, abstract = {A biocompatible, biodegradable and FDA-approved polymer [Poly lactic-co-glycolic acid (PLGA)] was used to prepare the nanoparticles (NPs) to observe the effect of solvents, stabilizers and their concentrations on the physical properties of the PLGA-NPs, following the encapsulation and in vitro release of Indomethacin (IND). PLGA-NPs were prepared by the single-emulsion solvent evaporation technique using dichloromethane (DCM)/chloroform as the organic phase with Polyvinyl-alcohol (PVA)/Polyvinylpyrrolidone (PVP) as stabilizers to encapsulate IND. The effects of different proportions of PVA/PVP with DCM/chloroform on the physiochemical properties (particle size, the polydispersity index, the zeta potential by Malvern Zetasizer and morphology by SEM) of the NPs were investigated. DSC was used to check the physical state, the possible complexation of PLGA with stabilizer(s) and the crystallinity of the encapsulated drug. Stabilizers at all concentrations produced spherical, regular-shaped, smooth-surfaced discrete NPs. Average size of 273.2-563.9 nm was obtained when PVA (stabilizer) with DCM, whereas it ranged from 317.6 to 588.1 nm with chloroform. The particle size was 273.2-563.9 nm when PVP was the stabilizer with DCM, while it was 381.4-466.6 nm with chloroform. The zeta potentials of PVA-stabilized NPs were low and negative (-0.62 mV) while they were comparatively higher and positive for PVP-stabilized NPs (+17.73 mV). Finally, drug-loaded optimal NPs were composed of PLGA (40 mg) and IND (4 mg) in 1 mL DCM/chloroform with PVA/PVP (1-3%), which resulted in sufficient encapsulation (54.94-74.86%) and drug loading (4.99-6.81%). No endothermic peak of PVA/PVP appeared in the optimized formulation, which indicated the amorphous state of IND in the core of the PLGA-NPs. The in vitro release study indicated a sustained release of IND (32.83-52.16%) from the PLGA-NPs till 72 h and primarily followed the Higuchi matrix release kinetics followed by Korsmeyer-Peppas models. The cell proliferation assay clearly established that the organic solvents used to prepare PLGA-NPs had evaporated. The PLGA-NPs did not show any particular toxicity in the HepG2 cells within the dose range of IND (250-500 mu g/mL) and at an equivalent concentration of PLGA-NPs (3571.4-7142.7 mu g/mL). The cytotoxicity of the hepatotoxic drug (IND) was reduced by its encapsulation into PLGA-NPs. The outcomes of this investigation could be implemented to prepare PLGA-NPs of acceptable properties for the encapsulation of low/high molecular weight drugs. It would be useful for further in vitro and in vivo applications to use this delivery system.}, keywords = {CYTOTOXICITY; MORPHOLOGY; NANOPARTICLES; Indomethacin; encapsulation; Solvents; PLGA; Drug release; PARTICLE-SIZE; STABILIZERS}, year = {2022}, eissn = {1999-4923}, orcid-numbers = {Alshamsan, Aws/0000-0002-8950-6571} } @article{MTMT:32942872, title = {Synthesis of polyurethane/polyurea microcapsules carrying diisocyanate in self-healing epoxy coating}, url = {https://m2.mtmt.hu/api/publication/32942872}, author = {Chau Ngoc Mai and La Thi Thai Ha and Nguyen Kieu Oanh}, doi = {10.1002/vjch.202100114}, journal-iso = {VIET J CHEM}, journal = {VIETNAM JOURNAL OF CHEMISTRY}, volume = {60}, unique-id = {32942872}, issn = {0866-7144}, abstract = {Recently, self-healing coating has been emerged and become one of the most crucial and critical materials with an excellent potential to repair physical damage and prevent cracks from expansion as an anticorrosion element to lengthen the coating lifespan. The determining factor in self-healing coating is that the microcapsules containing a self-curing liquid, which quickly fills up the cracks when the coatings are cut. Microcapsule embracing isophorone diisocyanate (IPDI) as a strong self-healing agent requiring no catalyst has been continuously innovated to be utilized in reality; however, its core content is still low (50-70 %) and the effects on it were not systematically investigated. Therefore, this study aimed to synthesize polyurethane/polyurea microcapsules carrying a higher content of IPDI to be potentially applied in self-healing epoxy coating. As a result, the newly developed spherical microcapsules were obtained with a core content of nearly 80 %, which is far higher than previous research. Moreover, the self-healing ability of epoxy coating containing 10 wt.% of these microcapsules was apparently demonstrated as illustrated in SEM images, along with its excellent anticorrosion, preventing 92.5 % of cracks from corrosion after immersed in 3.5 % NaCl solution for 72 hours.}, keywords = {Self-healing; Microcapsules; epoxy coating; Isophorone diisocyanate; pre-polyurethane}, year = {2022}, eissn = {2572-8288}, pages = {257-265} } @article{MTMT:33849050, title = {Novolac-based microcapsules containing isocyanate reagents for self-healing applications}, url = {https://m2.mtmt.hu/api/publication/33849050}, author = {Efterpi, Avdeliodi and Amaia, Soto Beobide and George, A. Voyiatzis and Georgios, Bokias and Kallitsi, Joannis K.}, doi = {10.1016/j.porgcoat.2022.107204}, journal-iso = {PROG ORG COAT}, journal = {PROGRESS IN ORGANIC COATINGS}, volume = {173}, unique-id = {33849050}, issn = {0300-9440}, abstract = {Microcapsules (MCs) containing isocyanate compounds for use as self-healing materials in waterborne polyurethane coatings have been synthesized, in the presence of modified Novolac resins. With modification of Novolac resin, it is succeeded partial or total protection (Benzylation and Acetylation) of its hydroxyl groups. The idea here is to use a protected Novolac resin as the organic substrate for the encapsulation of the less reactive Isophorone isocyanate (IPDI) while the more reactive one, Methylene diphenyl diisocyanate (MDI), is used for the shell formation. Based on that strategy microcapsules of different morphologies and sizes were obtained, depending on the agitation conditions, as revealed using SEM and optical microscopy. Selective extraction was performed to determine the amount of the less reactive isocyanate (IPDI) stored inside the capsules through FTIR-ATR spectroscopy and isocyanate titration as well as the stability of IPDI inside the capsules over time. As determined, microcapsules based on Acetyl-modified Novolac resin encapsulated 96 wt% of IPDI monomer; this amount is about five and ten times higher than that encapsulated in MCs based on by Benzyl-modified Novolac resin or unprotected Novolac resin, respectively. At the same time, MCs based on Acetyl-modified Novolac resin were stable, maintaining approximately 80 % of the initial isocyanate content after two months of storage under inert conditions. Finally, the self-healing ability of the microcapsules was tested by adding selected IPDI-loaded microcapsules in waterborne polyurethane dispersions. It was proven that the Acetyl-modified Novolac-based MCs showed efficient healing behavior, in the absence of any catalyst, on the polyurethanes' surfaces when scratched artificially.}, keywords = {POLYURETHANE; Self-healing; Microcapsules; Isophorone diisocyanate; Novolac resin}, year = {2022}, eissn = {1873-331X} } @article{MTMT:32942873, title = {Novel Pomegranate-Nanoparticles Ameliorate Cisplatin-Induced Nephrotoxicity and Improves Cisplatin Anti-Cancer Efficacy in Ehrlich Carcinoma Mice Model}, url = {https://m2.mtmt.hu/api/publication/32942873}, author = {Harakeh, Steve and Almuhayawi, Mohammed S. and Akefe, Isaac O. and Saber, Saber H. and Al Jaouni, Soad K. and Alzughaibi, Torki and Almehmadi, Yousef and Ali, Soad Shaker and Bharali, Dhruba J. and Mousa, Shaker}, doi = {10.3390/molecules27051605}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {27}, unique-id = {32942873}, issn = {1420-3049}, abstract = {Cisplatin (CISP) is one of the most widely used anti-cancer chemotherapeutic agents with remarkable efficacy against various types of cancers. However, it has been associated with nephrotoxicity amongst other undesirable side effects. Pomegranate (PE) is a potent antioxidant and anti-inflammatory agent effective against cancer, with a superior benefit of not being associated with the common toxicities related to the use of conventional chemotherapeutic agents. However, the application of PE is limited by its reduced solubility and decreased bioavailability. We investigated the potential of a novel nanoparticle (NP) enclosing PE to enhance its solubility and improve its bioavailability, and efficacy to prevent CISP-associated nephrotoxicity in a mice model of Ehrlich solid carcinoma (ESC). All mice were grouped into four cohorts: (I) control, (II) tumor, (III) CISP, and (IV) CISP + PE-NPs. The data obtained demonstrated that PE-NPs was beneficial in potently ameliorating CISP-induced nephrotoxicity in ESC mice. PE-NPs significantly attenuated CISP-induced oxidative stress and lipid peroxidation in the kidney via improving activities of antioxidants (SOD, GSH, and CAT). Additionally, PE-NPs considerably decreased CISP-induced inflammation in the kidney by decreasing the levels of NF-kB, IL-1 beta, and TNF-alpha. Notably, PE-NPs did not assuage the antitumor efficacy of CISP as revealed by histological assessment and tumor weight data. In summary, PE-NPs may be a potent alternative anticancer therapy devoid of nephrotoxicity.}, keywords = {ANTIOXIDANT; cisplatin; nephrotoxicity; pomegranate; nano-formulation}, year = {2022}, eissn = {1420-3049}, orcid-numbers = {Mousa, Shaker/0000-0002-9294-015X} } @article{MTMT:32694085, title = {Thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy}, url = {https://m2.mtmt.hu/api/publication/32694085}, author = {Harkaeh, S. and Qari, Y. and Tashkandi, H. and Almuhayawi, M. and Saber, S.H. and aljahdali, E. and El-Shitany, N. and Shaker, S. and Lucas, F. and Alamri, T. and Al-Jaouni, S. and Mousa, S.}, doi = {10.1016/j.jksus.2021.101675}, journal-iso = {J KING SAUD UNIV SCI}, journal = {JOURNAL OF KING SAUD UNIVERSITY - SCIENCE}, volume = {34}, unique-id = {32694085}, issn = {1018-3647}, abstract = {Objectives: Cisplatin (CISP) is an effective chemotherapy used in the treatment of various types of cancer, but it causes nephrotoxicity and other adverse effects. Thymoquinone (THY) is an effective anti-inflammatory and antioxidant compound, which might protects against many chemotherapies associated toxicities. However, THY applications are hindered by its poor solubility and low bioavailability. This study evaluated the efficacy of a novel nanoparticle (NP) encapsulting THY to overcome its poor solubility, enhance its bioavilability, efficacy for the protection against CISP-induced nephrotoxicity in an Ehrlich solid carcinoma (ESC) mice model. Methods: Four treatment groups were included: 1) control, 2) tumour, 3) CISP, and 4) CISP + NP THY. Results: The results showed that NP THY was effective in preventing CISP-induced kidney toxicity in ESC mice and improved its function and pathology. NP THY effectively ameliorated CISP-induced oxidative stress conditions in the kidney tissue via increasing the levels of antioxidants both non-enzymatic (GSH) and enzymatic (SOD and CAT). NP THY, also, significantly reduced CISP-induced kidney inflammation by reducing TNF-α, IL-1β, and NF-kB levels. NP THY didn't hinder the antitumor activity of CISP as shown by tumour weight and histological examination data. Conclusions: In conclusion, NP THY could be an adjuvant therapy to CISP cancer treatment to prevent associated nephrotoxicity and other adverse effects without compromising CISP antitumor efficacy. © 2021 The Author(s)}, keywords = {ANTIOXIDANT; cisplatin; nephrotoxicity; anti-inflammatory; nanoformulation; thymoquinone; Ehrlich}, year = {2022}, eissn = {2213-686X} } @article{MTMT:32694088, title = {Chitosan-coated plga nanoparticles encapsulating triamcinolone acetonide as a potential candidate for sustained ocular drug delivery}, url = {https://m2.mtmt.hu/api/publication/32694088}, author = {Dandamudi, M. and McLoughlin, P. and Behl, G. and Rani, S. and Coffey, L. and Chauhan, A. and Kent, D. and Fitzhenry, L.}, doi = {10.3390/pharmaceutics13101590}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {13}, unique-id = {32694088}, issn = {1999-4923}, abstract = {The current treatment for the acquired retinal vasculopathies involves lifelong repeated intravitreal injections of either anti-vascular endothelial growth factor (VEGF) therapy or modulation of inflammation with steroids. Consequently, any treatment modification that decreases this treatment burden for patients and doctors alike would be a welcome intervention. To that end, this research aims to develop a topically applied nanoparticulate system encapsulating a corticosteroid for extended drug release. Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) supports the controlled release of the encapsulated drug, while surface modification of these NPs with chitosan might prolong the mucoadhesion ability leading to improved bioavailability of the drug. Triamcinolone acetonide (TA)-loaded chitosan-coated PLGA NPs were fabricated using the oil-in-water emulsion technique. The optimized surface-modified NPs obtained using Box-Behnken response surface statistical design were reproducible with a particle diameter of 334 ± 67.95 to 386 ± 15.14 nm and PDI between 0.09 and 0.15. These NPs encapsulated 55–57% of TA and displayed a controlled release of the drug reaching a plateau in 27 h. Fourier-transform infrared spectroscopic (FTIR) analysis demonstrated characteristic peaks for chitosan (C-H, CONH2 and C-O at 2935, 1631 and 1087 cm−1, respectively) in chitosan-coated PLGA NPs. This result data, coupled with positive zeta potential values (ranged between +26 and +33 mV), suggests the successful coating of chitosan onto PLGA NPs. Upon coating of the NPs, the thermal stability of the drug, polymer, surfactant and PLGA NPs have been enhanced. The characteristics of the surface-modified NPs supports their use as potential candidates for topical ocular drug delivery for acquired retinal vasculopathies. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.}, keywords = {ARTICLE; controlled study; NANOPARTICLES; corticosteroid; reproducibility; drug stability; particle size; drug bioavailability; drug coating; nanoparticle; PLGA; surface property; triamcinolone acetonide; triamcinolone acetonide; thermostability; sustained drug release; surfactant; controlled drug release; polyglactin; Chitosan; Chitosan; mucoadhesion; Nanoencapsulation; nanoemulsion; ocular drug delivery; intraocular drug administration; retinal vascular disease; posterior segment eye diseases; Chitosan-coated nanoparticles}, year = {2021}, eissn = {1999-4923} } @article{MTMT:32303384, title = {Scaffold-based osteogenic dual delivery system with melatonin and BMP-2 releasing PLGA microparticles}, url = {https://m2.mtmt.hu/api/publication/32303384}, author = {Jarrar, Hala and Altindal, Damla Cetin and Gumusderelioglu, Menemse}, doi = {10.1016/j.ijpharm.2021.120489}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {600}, unique-id = {32303384}, issn = {0378-5173}, abstract = {The growing safety problems about the use of bone morphogenetic protein 2 (BMP-2) is one of the recent issues that was improved by using low doses of BMP-2 with the support of other osteoinductive agents and/or using appropriate carriers. The aim of the present study is to investigate the effect of scaffold-based dual release system including melatonin (MEL) and BMP-2 loaded polylactic-co-glycolic acid (PLGA) microparticles on the osteogenic activity of pre-osteoblastic MC3T3-E1 cells. MEL and BMP-2 loaded microparticles were prepared by double emulsion solvent evaporation method in the average diameters of similar to 2 mu m and similar to 11 mu m, respectively and loaded into chitosan/hydroxyapatite (HAp) scaffolds. In vitro MC3T3-E1 culture studies were carried out comparatively with blank scaffolds, single (BMP-2 or MEL) releasing groups and dual (BMP-2 and MEL) releasing group. Microscopic observations and hematoxylin/eosin staining showed enhanced number of cells and dense ECM in dual release group. The expressions of differentiation markers, Runt-related transcription factor 2 (RUNX2) and alkaline phosphatase (ALP) and also mineralization were higher in dual release group than that of the other groups. Our findings showed that BMP-2 at low doses (similar to 20 ng per scaffold) was sufficient in terms of osteogenic activity with controlled release systems where it was used in combination with MEL (similar to 10 mu g per scaffold).}, keywords = {SCAFFOLD; melatonin; controlled release; BMP-2; bone tissue engineering; PLGA microparticles}, year = {2021}, eissn = {1873-3476} } @article{MTMT:32303385, title = {Engineering microenvironment of biodegradable polyester systems for drug stability and release control}, url = {https://m2.mtmt.hu/api/publication/32303385}, author = {Khaliq, Nisar Ul and Chobisa, Dhawal and Richard, Coralie A. and Swinney, Monica R. and Yeo, Yoon}, doi = {10.4155/tde-2020-0113}, journal-iso = {THER DELIV}, journal = {THERAPEUTIC DELIVERY}, volume = {12}, unique-id = {32303385}, issn = {2041-5990}, abstract = {Polymeric systems made of poly(lactic acid) or poly(lactic-co-glycolic acid) are widely used for long-term delivery of small and large molecules. The advantages of poly(lactic acid)/poly(lactic-co-glycolic acid) systems include biodegradability, safety and a long history of use in US FDA-approved products. However, as drugs delivered by the polymeric systems and their applications become more diverse, the significance of microenvironment change of degrading systems on long-term drug stability and release kinetics has gained renewed attention. In this review, we discuss various issues experienced with acidifying microenvironment of biodegradable polymer systems and approaches to overcome the detrimental effects of polymer degradation on drug stability and release control.}, keywords = {Drug Delivery Systems; drug stability; Poly(lactic acid); Poly(lactic-co-glycolic acid); RELEASE KINETICS; Acidic microenvironment}, year = {2021}, eissn = {2041-6008}, pages = {37-54}, orcid-numbers = {Chobisa, Dhawal/0000-0001-5856-1386; Yeo, Yoon/0000-0001-9505-7701} } @article{MTMT:32303383, title = {Crucial Role of PLGA Nanoparticles in Mitigating the Amiodarone-Induced Pulmonary Toxicity}, url = {https://m2.mtmt.hu/api/publication/32303383}, author = {Motawea, Amira and Ahmed, Dalia Alsaied Moustafa and El-Mansy, Ahmed A. and Saleh, Noha Mohamed}, doi = {10.2147/IJN.S314074}, journal-iso = {INT J NANOMED}, journal = {INTERNATIONAL JOURNAL OF NANOMEDICINE}, volume = {16}, unique-id = {32303383}, issn = {1176-9114}, abstract = {Background: Amiodarone (AMD) is a widely used anti-arrhythmic drug, but its administration could be associated with varying degrees of pulmonary toxicity. In attempting to circumvent this issue, AMD-loaded polymeric nanoparticles (AMD-loaded NPs) had been designed.Materials and Methods: AMD was loaded in NPs by the nanoprecipitation method using two stabilizers: bovine serum albumin and Kolliphor (R) P 188. The physicochemical properties of the AMD-loaded NPs were determined. Among the prepared NPs, two ones were selected for further investigation of spectral and thermal analysis as well as morphological properties. Additionally, in vitro release patterns were studied and kinetically analyzed at different pH values. In vitro cytotoxicity of an optimized formula (NP4) was quantified using A549 and Hep-2 cell lines. In vivo assessment of the pulmonary toxicity on Sprague Dawley rats via histopathological and immunohistochemical evaluations was applied.Results: The developed NPs achieved a size not more than 190 nm with an encapsulation efficiency of more than 88%. Satisfactory values of loading capacity and yield were also attained. The spectral and thermal analysis demonstrated homogeneous entrapment of AMD inside the polymeric matrix of NPs. Morphology revealed uniform, core-shell structured, and sphere-shaped particles with a smooth surface. Furthermore, the AMD-loaded NPs exhibited a pH-dependent and diffusion-controlled release over a significant period without an initial burst effect. NP4 demonstrated a superior cytoprotective efficiency by diminishing cell death and significantly increasing the IC50 by more than threefold above the pure AMD. Also, NP4 ameliorated AMD-induced pulmonary damage in rats. Significant downregulation of inflammatory mediators and free radicle production were noticed in the NP4-treated rats.Conclusion: The AMD-loaded NPs could ameliorate the pulmonary injury induced by the pure drug moieties. Cytoprotective, anti-fibrotic, anti-inflammatory, and antioxidant properties were presented by the optimized NPs (NP4). Future studies may be built on these findings for diminishing AMD-induced off-target toxicities.}, keywords = {CYTOTOXICITY; NANOPARTICLES; PLGA; amiodarone; BSA; pulmonary toxicity}, year = {2021}, eissn = {1178-2013}, pages = {4713-4737} } @article{MTMT:32694086, title = {Coaxially electrospun 5-fluorouracil-loaded PLGA/PVP fibrous membrane for skin tumor treatment}, url = {https://m2.mtmt.hu/api/publication/32694086}, author = {Yuan, C. and Long, X. and Li, J. and Cai, Q.}, doi = {10.1088/1748-605X/ac2887}, journal-iso = {BIOMED MATER}, journal = {BIOMEDICAL MATERIALS}, volume = {16}, unique-id = {32694086}, issn = {1748-6041}, abstract = {As a biocompatible and biodegradable polymer, poly(lactide-co-glycolide) (PLGA) has been widely used as a carrier to achieve controlled drug delivery in various forms. Focusing on skin tumor treatment, herein 5-fluorouracil (5-FU) was embedded into the core of coaxially electrospun PLGA fibers to get a drug-loaded core-shell fibrous membrane. In the coaxial electrospinning, poly(vinylpyrrolidone) was applied in the inner flow to facilitate the formation of the core-shell structured fibers. The morphology and micro-structure of the fibers were characterized by scanning electron microscope and transmission electron microscope. The influences of the molecular weights and chemical compositions of PLGA copolymers on the release behaviors were studied. The cytotoxicity of the fibers was characterized by cell proliferation and living-dead cell staining experiments. The results showed that faster release rates would be obtained if the copolymers were of lower molecular weights and higher fraction of glycidyl unit. All the prepared 5-FU loaded fibrous membranes were non-cytotoxic, suggesting their potential applications in skin tumor treatment. © 2021 IOP Publishing Ltd.}, keywords = {FIBERS; ARTICLE; MOUSE; TUMORS; CYTOTOXICITY; human; chemical composition; Molecular weight; Molecular weight; controlled study; nonhuman; animal experiment; animal cell; transmission electron microscopy; transmission electron microscopy; cell proliferation; cell proliferation; scanning electron microscopy; scanning electron microscopy; drug delivery system; Drug Delivery Systems; chemical structure; FLUOROURACIL; cancer therapy; structure analysis; biocompatibility; biocompatibility; staining; Drug release; DRUG-DELIVERY SYSTEMS; polyglactin; skin tumor; Povidone; copolymer; Biodegradable polymers; Shells (structures); Core shell structure; Core-shell structure; 5-FLUOROURACIL; 5-FLUOROURACIL; Electrospinning; Electrospinning; Fibrous membranes; Targeted drug delivery; Controlled drug delivery; Skin tumour; Coaxial electrospinning; Coaxial electrospinning; B16 cell line; poly(lactide-co-glycolide); poly(lactide-co-glycolide); tumor treatment; poly-lactide-co-glycolide; core shell nanoparticle; Polylactide-co-glycolide; Poly lactide-co-glycolide}, year = {2021}, eissn = {1748-605X} } @article{MTMT:31419834, title = {In vitro and in vivo evaluation of levodopa-loaded nanoparticles for nose to brain delivery}, url = {https://m2.mtmt.hu/api/publication/31419834}, author = {Arisoy, Sema and Sayiner, Ozgun and Comoglu, Tansel and Onal, Deniz and Atalay, Ozbeyen and Pehlivanoglu, Bilge}, doi = {10.1080/10837450.2020.1740257}, journal-iso = {PHARM DEV TECHNOL}, journal = {PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY}, volume = {25}, unique-id = {31419834}, issn = {1083-7450}, abstract = {Parkinson's disease (PD) is a neurodegenerative disease which is characterized by the loss of dopaminergic neurons in the brain. Levodopa is the drug of choice in the treatment of PD but it exhibits low oral bioavailability (30%) and very low brain uptake due to its extensive metabolism by aromatic amino acid decarboxylase in the peripheral circulation. Moreover, levodopa has psychic, gastrointestinal, and cardiovascular side effects, and most importantly, short and frequent stimulation of dopamine receptors lead to undesirable conditions such as dyskinesia over time. The challenges are to increase the therapeutic efficiency, the bioavailability and decreasing the unfavourable side effects of levodopa. Biocompatible nano-sized drug carriers could address these challenges at molecular level. For this purpose, levodopa-loaded Poly (lactide-co-glycolide) acid nanoparticles were prepared by double emulsion-solvent evaporation method for nose to brain drug delivery. Parameters such as homogenization speed, and external and internal phase content were modified to reach the highest loading efficiency. F1-1 coded formulation showed prolonged release up to 9 h. Carbodiimide method was used for surface modification studies of nanoparticles. The efficacy of the selected nanoparticle formulation has been demonstrated by in vivo experiments in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced PD model in mice.}, keywords = {Parkinson disease; PLGA; Nasal drug delivery; levodopa nanoparticles; wheat germ aglutinine conjugation; in vivo Parkinson disease model}, year = {2020}, eissn = {1097-9867}, pages = {735-747}, orcid-numbers = {Onal, Deniz/0000-0002-9604-4539} } @article{MTMT:32694091, title = {Influence of emulsifiers on the formation and in vitro anticancer activity of epirubicin loaded PLGA nanoparticles}, url = {https://m2.mtmt.hu/api/publication/32694091}, author = {Esim, O. and Bakirhan, N.K. and Sarper, M. and Savaser, A. and Ozkan, S.A. and Ozkan, Y.}, doi = {10.1016/j.jddst.2020.102027}, journal-iso = {J DRUG DELIV SCI TEC}, journal = {JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY}, volume = {60}, unique-id = {32694091}, issn = {1773-2247}, abstract = {Surfactants play an important role in preparation of nanoparticles. In this study, it was aimed to investigate the effect of surfactant type and concentration on development of epirubicin loaded Poly (D,L-lactide-coglycolide acid) (PLGA) nanoparticles. In this regard PVA, TPGS, sodium cholate and Poloxamer 188 were used as surfactants to prepare epirubicin loaded PLGA nanoparticles in three concentrations. It was found that the particle size of nanoparticles was varied in the range 109.6 ± 5.19 nm and 511.5 ± 23.99 nm. The size of nanoparticles was smaller when sodium cholate was used (p < 0.05). It was observed that encapsulation efficiency of nanoparticles was higher for those emulsified by sodium cholate at low concentrations (0.3%) (p < 0.05). Lower IC50 doses were found lower at 24 h when nanoparticles fabricated by sodium cholate (4.71 ± 0.67 μg/mL, 17.96 ± 1.25 μg/mL and 27.78 ± 1.44 μg/mL for 0.3%, 1% and 2%) compared with drug solution (218.00 ± 20.33 μg/mL) in human lung squamous cell carcinoma (SK-MES-1) cells (p < 0.05). Both qualitative fluorescent images and quantitative results showed that nanoparticles prepared with sodium cholate demonstrated greater cellular uptake of nanoparticles. Thus, sodium cholate could be useful in developing epirubicin loaded PLGA nanoparticles for non-small cell lung cancer treatment. © 2020 Elsevier B.V.}, keywords = {APOPTOSIS; ARTICLE; FLUORESCENCE; human; in vitro study; human cell; particle size; nanoparticle; nanoparticle; epirubicin; epirubicin; qualitative analysis; ANTINEOPLASTIC ACTIVITY; Cholic Acid; emulsifying agent; surfactant; polyglactin; drug solution; Nanoencapsulation; cytotoxicity assay; Sodium cholate; lung squamous carcinoma cell line}, year = {2020}, eissn = {2588-8943} } @article{MTMT:31692924, title = {Process parameters of microsphere preparation based on propylene carbonate emulsion-precursors}, url = {https://m2.mtmt.hu/api/publication/31692924}, author = {Grizic, Daris and Lamprecht, Alf}, doi = {10.1080/02652048.2020.1823501}, journal-iso = {J MICROENCAPSUL}, journal = {JOURNAL OF MICROENCAPSULATION}, unique-id = {31692924}, issn = {0265-2048}, abstract = {AimThis study aimed for a detailed understanding of the impact of different process parameters involved during celecoxib-loaded microsphere preparation based on propylene carbonate emulsion-precursors.MethodsMicrospheres were prepared by a modified emulsification-solvent extraction method. Performed investigations included polymer solubility and viscosity, microsphere size, morphology and stability, propylene carbonate content as well as celecoxib solid state, content and release.ResultsRough-walled round microspheres with sizes between 21 mu m and 122 mu m and an internal sponge-like structure filled with residual propylene carbonate (content between 1.9 +/- 0.1% and 6.7 +/- 0.5% w/w) were obtained. Encapsulation efficiencies varied between 28.3 +/- 0.1% and 66.8 +/- 1.0%. The release rates were affected by the polymer concentration, the emulsion phase ratio and the residual propylene carbonate content (t(50%) varied between 2.2 hours and 23.4 hours).ConclusionsThis study identified the most relevant process parameters for this new preparation method for the model drug celecoxib.}, keywords = {microencapsulation; PROPYLENE CARBONATE; PLGA; celecoxib; Process parameters}, year = {2020}, eissn = {1464-5246} } @article{MTMT:31744086, title = {Preparation and in vitro characterization of valsartan-loaded ethyl cellulose and poly(methyl methacrylate) nanoparticles}, url = {https://m2.mtmt.hu/api/publication/31744086}, author = {Hajba-Horváth, Eszter and Biró, Emese and Mirankó, Mirella and Fodorné Kardos, Andrea and Trif, László and Feczkó, Tivadar}, doi = {10.1039/D0RA07218D}, journal-iso = {RSC ADV}, journal = {RSC ADVANCES}, volume = {10}, unique-id = {31744086}, issn = {2046-2069}, year = {2020}, eissn = {2046-2069}, pages = {43915-43926}, orcid-numbers = {Hajba-Horváth, Eszter/0000-0003-4662-5594; Trif, László/0000-0002-3960-1829} } @article{MTMT:31419836, title = {Conjugated linoleic acid loaded nanostructured lipid carrier as a potential antioxidant nanocarrier for food applications}, url = {https://m2.mtmt.hu/api/publication/31419836}, author = {Hashemi, Fatemeh Sadat and Farzadnia, Farin and Aghajani, Abdoreza and NobariAzar, Farnaz Ahmadzadeh and Pezeshki, Akram}, doi = {10.1002/fsn3.1712}, journal-iso = {FOOD SCI NUTR}, journal = {FOOD SCIENCE AND NUTRITON}, unique-id = {31419836}, issn = {2048-7177}, abstract = {The encapsulation of fatty acids in nanocarrier systems is a very effective technique in improving their biological efficiency and controlled delivery. Nanostructured lipid carrier (NLC) is a major type of lipid-based nanoparticle. This study is focused on producing nanolipid carrier containing conjugated linoleic acid and fortifying low-fat milk using this nanoparticle. Nanostructured lipid carriers were produced by hot high-shear homogenization containing 1.5% Poloxamer 407, cocoa butter as solid lipid, and conjugated linoleic acid as liquid oil in ratio of 10:1. Results showed that the nanoparticles sized 81 nm with monomodular dispersity and the system was stable at 4 and 22 degrees C for 40 days. Zeta potential and encapsulation efficiency (%EE) were -15.8 mV and 98.2%, respectively. Scanning electron microscopy (SEM) showed that the particles are in spiral form and small size and no significant aggregation was observed because of few changes in the system turbidity after storage time. The result of oxidative stability showed that using Nanostructured lipid carriers system resulted in lower malone dialdehyde production. Conjugated linoleic acid was protected at level of 3.9% of milk fatty acids in Nanostructured lipid carrier formulation during storage time. Based on these findings, Nanostructured lipid carriers system is an appropriate and stable nanocarrier system for delivery of nutraceuticals in foods and can be used in protecting them against oxidation, heating, and other processes in order to fortify foods and beverages.}, keywords = {particle size; Gas chromatography; Conjugated linoleic acid; low-fat milk; nano lipid carrier}, year = {2020}, eissn = {2048-7177} } @article{MTMT:32694089, title = {Interfacial tension effects on the properties of PLGA microparticles}, url = {https://m2.mtmt.hu/api/publication/32694089}, author = {Otte, A. and Sharifi, F. and Park, K.}, doi = {10.1016/j.colsurfb.2020.111300}, journal-iso = {COLLOID SURFACE B}, journal = {COLLOIDS AND SURFACES B: BIOINTERFACES}, volume = {196}, unique-id = {32694089}, issn = {0927-7765}, abstract = {Many types of long-acting injectables, including in situ forming implants, preformed implants, and polymeric microparticles, have been developed and ultimately benefited numerous patients. The advantages of using long-acting injectables include greater patient compliance and more steady state drug plasma levels for weeks and months. However, the development of long-acting polymeric microparticles has been hampered by the lack of understanding of the microparticle formation process, and thus, control of the process. Of the many parameters critical to the reproducible preparation of microparticles, the interfacial tension (IFT) effect is an important factor throughout the process. It may influence the droplet formation, solvent extraction, and drug distribution in the polymer matrix, and ultimately drug release kinetics from the microparticles. This mini-review is focused on the IFT effects on drug-loaded poly(lactic-co-glycolic acid) (PLGA) microparticles. © 2020 Elsevier B.V.}, keywords = {Humans; ARTICLE; human; drug distribution; drug distribution; priority journal; drug blood level; drug delivery system; reproducibility; particle size; particle size; lactic acid; lactic acid; surface tension; surface tension; nanoparticle; Patient Compliance; Solvent extraction; Solvent extraction; Solvent extraction; Activation analysis; emulsifying agent; Drug release; solvent effect; INTERFACIAL TENSION; polyglactin; steady state; droplet formation; Polyglycolic Acid; Polyglycolic Acid; Processing parameters; Drug Liberation; Poly(lactic-co-glycolic acid); Controlled drug delivery; biofilm matrix; nanoemulsion; Polymeric implants; Polylactic Acid-Polyglycolic Acid Copolymer; drug release kinetics; Tensiometry; Polymeric microparticles; PLGA microparticles; PLGA microparticles; Microparticle formation; profile analysis tensiometry}, year = {2020}, eissn = {1873-4367} } @article{MTMT:31419832, title = {Sublingual dendritic cells targeting by aptamer: Possible approach for improvement of sublingual immunotherapy efficacy}, url = {https://m2.mtmt.hu/api/publication/31419832}, author = {Shahbaz, Sanaz Keshavarz and Varasteh, Abdol-Reza and Koushki, Khadijeh and Ayati, Seyed Hasan and Mashayekhi, Kazem and Sadeghi, Mahvash and Moghadam, Malihe and Sankian, Mojtaba}, doi = {10.1016/j.intimp.2020.106603}, journal-iso = {INT IMMUNOPHARMACOL}, journal = {INTERNATIONAL IMMUNOPHARMACOLOGY}, volume = {85}, unique-id = {31419832}, issn = {1567-5769}, abstract = {The efficacy improvement of current sublingual immunotherapy (SLIT) for preventing and treating respiratory airway allergic diseases is the main purpose of many investigations. In this study, we aimed to assess whether ovalbumin (Ova) encapsulated poly (lactic-co-glycolic) acid nanoparticles (PLGA NPs) decorated with dendritic cells (DCs)-specific aptamer could be applied for this purpose. The nanoparticles containing Ova were synthesized by emulsion/solvent evaporation method and attached to DCs-specific aptamer. Ova-sensitized BALB/c mice have been treated in five ways: subcutaneously with free Ova (SCIT), sublingually either with free Ova, Ova-PLGA NPs (two doses), Apt-Ova-PLGA NPs (two doses) and placebo/control Apt-Ova-PLGA NPs. For assessment of immunologic responses, IL-4, IFN-gamma, IL-17, IL10, and TGF-beta and IgE antibody levels were measured by ELISA and T cell proliferation were evaluated by MTT. In addition, lung and nasal histological examinations, NALF cells counting were carried out. Results declared that the lowest IgE and IL-4 levels were observed in Apt-Ova-PLGA NPs (both doses). In the other hands, Apt-Ova-PLGA NPs (high dose) showed the highest increase of IFN-gamma and TGF-beta, decrease of IL-17 levels, total cell count and T-cell proliferation. IL-10 levels showed more decrease in SCIT, Apt-Ova-PLGA NPs (high dose) and Ova-PLGA NPs (high dose) than other groups. Histopathological examinations also confirmed in vitro results. Our findings suggest SLIT with this functionalized delivery system could be a promising approach for promoting the SLIT efficiency by decreasing the required allergen doses through specific delivery of allergen to sublingual DCs and enhancing the suppression of allergic responses.}, keywords = {aptamer; SLIT; PLGA NPs; Rhinitis allergic diseases}, year = {2020}, eissn = {1878-1705} } @article{MTMT:30963270, title = {Preparation and characterization of atrazine-loaded biodegradable PLGA nanospheres}, url = {https://m2.mtmt.hu/api/publication/30963270}, author = {Chen Xiao-ting and Wang, Tongxin}, doi = {10.1016/S2095-3119(19)62613-4}, journal-iso = {J INTEGR AGRIC}, journal = {JOURNAL OF INTEGRATIVE AGRICULTURE}, volume = {18}, unique-id = {30963270}, issn = {2095-3119}, abstract = {Atrazine is the second mostly used herbicide in USA, but low utilization ratio causes severe environmental problem, so controlled release system is highly needed in order to minimize the negative impact on environment. In this paper, a herbicide delivery system, atrazine-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were prepared by forming an oil-in-water emulsion using the emulsion-solvent evaporation method. By varying the preparation conditions of PLGA-NPs, such as sonication time, surfactant content, solvent fraction, and polymer content, the particle sizes of the PLGA-NPs were well controlled from 204 to 520 nm. The morphology and size distribution of PLGA-NPs were evaluated using dynamic light scattering (DLS) and scanning electron microscopy (SEM). Both the encapsulation efficiency and release profile of the herbicide from the PLGA-NPs were typically evaluated by using 2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine (atrazine, ATZ) as the model. ATZ encapsulation efficiency within the PLGA-NPs was ranged from 31.6 to 50.5%. The release profiles of ATZ-loaded PLGA-NPs exhibited a much slower release rate in comparison with that of pure herbicide. The results demonstrated that the prepared PLGA-NPs had a high encapsulation efficiency and slow release rate, which could be used as a promising herbicide release system in agriculture to diminish the impact on the environment and minimize the potential harm to the farmers.}, keywords = {nanoparticle; Drug delivery; controlled release; PLGA; ATRAZINE}, year = {2019}, eissn = {2352-3425}, pages = {1035-1041} } @article{MTMT:31019666, title = {Evaluation of size and dose effects of rChe a 3 allergen loaded PLGA nanoparticles on modulation of Th2 immune responses by sublingual immunotherapy in mouse model of rhinitis allergic}, url = {https://m2.mtmt.hu/api/publication/31019666}, author = {Hajavi, Jafar and Hashemi, Maryam and Sankian, Mojtaba}, doi = {10.1016/j.ijpharm.2019.03.040}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {563}, unique-id = {31019666}, issn = {0378-5173}, year = {2019}, eissn = {1873-3476}, pages = {282-292} } @article{MTMT:30448497, title = {PLGA nano- and microparticles for the controlled release of florfenicol: Experimental and theoretical study}, url = {https://m2.mtmt.hu/api/publication/30448497}, author = {Karp, F. and Busatto, C. and Turino, L. and Luna, J. and Estenoz, D.}, doi = {10.1002/app.47248}, journal-iso = {J APPL POLYM SCI}, journal = {JOURNAL OF APPLIED POLYMER SCIENCE}, volume = {136}, unique-id = {30448497}, issn = {0021-8995}, abstract = {In this study, PLGA particle systems were studied for the controlled release of florfenicol, a broad spectrum antibiotic used in veterinary treatments. The emulsion-solvent evaporation technique was used for particle preparation. To evaluate the particle size, entrapment efficiency, and drug release behavior, factors such as solvent type, emulsification time and methods, and drug to polymer ratio were investigated. The results showed that the use of ethyl acetate and 2.5 min of ultrasonication or 30 min of homogenization can lead to sub-micron and micron-sized particles, respectively. Sizes between 200-300 nm and 2-3 mu m were obtained for ultrasonication and homogenization procedures, respectively. Entrapment efficiencies were around 20% for all systems and release profiles were size dependent. In addition, a mathematical model was implemented to simulate the florfenicol transport. The model predicts the florfenicol release and takes into account the particle size, polymer molecular weight, and autocatalytic polymer degradation. Simulation results are in good agreement with experimental results. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47248.}, keywords = {Drug Delivery Systems; Polyesters; biodegradable; theory and modeling}, year = {2019}, eissn = {1097-4628} } @article{MTMT:31019665, title = {Facile and efficient isocyanate microencapsulation via SDBS/PVP synergetic emulsion}, url = {https://m2.mtmt.hu/api/publication/31019665}, author = {Lu, Wei and Meng, Qingwei and Qin, Chuanrui and Li, Jinliang and Qi, Guansheng and Kong, Biao and He, Zhenglong}, doi = {10.1002/app.48045}, journal-iso = {J APPL POLYM SCI}, journal = {JOURNAL OF APPLIED POLYMER SCIENCE}, volume = {136}, unique-id = {31019665}, issn = {0021-8995}, abstract = {A binary emulsion system via combination of sodium dodecylbenzenesulfonate (SDBS) and polyvinyl pyrrolidone (PVP) was employed to prepare microcapsules containing isophorone diisocyanate. The effect of different concentrations of SDBS and PVP on the size and distribution of capsules was investigated. The results showed that uniform and size-controllable capsules were synthesized by synergistic function of SDBS and PVP. Characteristics of capsule were studied by optical microscopy, Fourier transform infrared spectrometry, scanning electron microscopy, thermal gravimetric analysis, and H-1 NMR. The results revealed that the core content and yield of the spherical capsules were approximately 65.7 and 79 wt %, respectively, at the capsule diameter of similar to 115 mu m. The residue core content of microcapsules was approximately 44.7 wt % after immersion in water for 10 days. And its self-healing epoxy coatings showed excellent corrosion resistance performance after accelerated corrosion tests. These results exhibited the feasibility and great application prospect of the multiemulsifiers system in the microcapsule synthesis process. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48045.}, keywords = {encapsulation; Self-healing; Microcapsules; ISOCYANATE; binary emulsion system}, year = {2019}, eissn = {1097-4628}, orcid-numbers = {He, Zhenglong/0000-0002-8088-8593} } @article{MTMT:31019664, title = {Influence of Solvent Evaporation Technique Parameters on Diameter of Submicron Lamivudine-Poly-epsilon-Caprolactone Conjugate Particles}, url = {https://m2.mtmt.hu/api/publication/31019664}, author = {Urbaniak, Tomasz and Musial, Witold}, doi = {10.3390/nano9091240}, journal-iso = {NANOMATERIALS-BASEL}, journal = {NANOMATERIALS}, volume = {9}, unique-id = {31019664}, abstract = {The size of active pharmaceutical ingredient carrier is one of the key properties considered during design of submicron drug delivery systems. Particle diameter may determine drug biodistribution, cellular uptake, and elimination path. Solvent evaporation technique is a flexible method of particle preparation, in which various macromolecules and drugs may be employed. Parameters of emulsion obtained as first step of particle preparation are crucial in terms of particle size, drug loading, and morphology. The aim of the study was to investigate the influence of emulsion preparation parameters on diameter of resulting particles. Impact of surfactant type and concentration, homogenization time, homogenization rate, phase ratio, and conjugate concentration were evaluated. Model drug lamivudine was covalently bound to polymer and applied in solvent evaporation method in order to overcome issues related to drug loading and provide method-independent incorporation. Synthesized drug-polymer conjugate and obtained particles were evaluated via dynamic light scattering, chromatography, scanning electron microscopy, and spectroscopic methods. Covalent bonding between drug and polymeric chain was confirmed, estimated drug content per milligram of conjugate was 19 mu g. Among employed colloid stabilizer, poly(vinyl alcohol) was proven to be most effective. Homogenization rate and surfactant concentration were identified as crucial parameters in terms of particle diameter control.}, keywords = {Drug delivery; Biodegradable polymers; drug-polymer conjugates; submicron particle preparation; solvent evaporation technique}, year = {2019}, eissn = {2079-4991} } @article{MTMT:27555397, title = {Effect of process variables on formulation, in-vitro characterisation and subcutaneous delivery of insulin PLGA nanoparticles: An optimisation study}, url = {https://m2.mtmt.hu/api/publication/27555397}, author = {Abdelkader, Dalia H and El-Gizawy, Sanaa A and Faheem, Ahmed M and McCarron, Paul A and Osman, Mohamed A}, doi = {10.1016/j.jddst.2017.10.004}, journal-iso = {J DRUG DELIV SCI TEC}, journal = {JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY}, volume = {43}, unique-id = {27555397}, issn = {1773-2247}, abstract = {This study was initiated to investigate the effect of PLGA concentration, PVA concentration, internal to external phase ratio (IEPR), PEG molecular weight and concentration on mean particle size, zeta potential, polydispersity index (PDI), percentage drug entrapment and in vitro release profile. Using PLGA (50: 50) as the carrier, insulin nanoparticles (NP) were prepared using double emulsion solvent evaporation technique. The particle size was analysed by dynamic light scattering (DLS) and the geometrical shape was examined using scanning electron microscopy (SEM). Mean particle size was highly dependent on the combined effect of PLGA and PVA concentrations. Drug entrapment would be greatly controlled by PLGA concentration and internal to external phase ratio. Addition of PEG could modulate in vitro release behavior of insulin with initial burst at the first 12 h and sustain the drug release for 6 days. Insulin integrity was assessed in vitro using MALDI-TOF mass spectroscopy. The optimised NP formulation, had particle size of 202.60 nm and percent entrapment efficiency (EE) equal to 67.72%, was tested in vivo to examine its hypoglycemic effect after subcutaneous injection. Insulin NP had a significant hypoglycemic effect comparing to free insulin (p < 0.01) and insulin zinc suspension (p < 0.05).}, keywords = {NANOPARTICLES; PLGA; human insulin; sustained delivery; Acute diabetes; Poly (ethylene glycol)}, year = {2018}, eissn = {2588-8943}, pages = {160-171} } @article{MTMT:30448506, title = {Enhanced cutaneous wound healing in rats following topical delivery of insulin-loaded nanoparticles embedded in poly(vinyl alcohol)-borate hydrogels}, url = {https://m2.mtmt.hu/api/publication/30448506}, author = {Abdelkader, Dalia H. and Tambuwala, Murtaza M. and Mitchell, Christopher A. and Osman, Mohamed A. and El-Gizawy, Sanaa A. and Faheem, Ahmed M. and El-Tanani, Mohamed and McCarron, Paul A.}, doi = {10.1007/s13346-018-0554-0}, journal-iso = {DRUG DELIV TRANSLAT RES}, journal = {DRUG DELIVERY AND TRANSLATIONAL RESEARCH}, volume = {8}, unique-id = {30448506}, issn = {2190-393X}, abstract = {Insulin plays an important role in the wound healing process. but its method of delivery to the wound bed and subsequent effect on rate of healing is less well investigated. In this study, we evaluated the therapeutic effectiveness of topical human insulin delivery using a nanoparticulate delivery system suspended in a structured hydrogel vehicle. Poly(lactide-co-glycolide) (PLGA) nanoparticles (NP) of 202.6 nm diameter and loaded with 33.86 mu g insulin per milligram of polymer were formulated using a modified double-emulsion solvent evaporation technique and dispersed in a dilatant hydrogel (poly(vinyl alcohol)-borate). Importantly, this hydrogel formulation was used to achieve ultimate contact with the wound bed. A comparison of wound healing rates following local administration of insulin in the free and nanoencapsulated forms was performed in diabetic and healthy rats. In non-diabetic rats, there was no significant difference between healing observed in control and wounds treated with free insulin (p > 0.05), whereas treatment with insulin encapsulated within PLGA NP showed a significant difference (p < 0.001). In diabetic cohorts, both free insulin and nanoencapsulated insulin induced significant improvement in wound healing when compared to controls, with better percentage wound injury indices observed with the colloidal formulation. At day 10 of the experiment, the difference between percentage wound injury indices of insulin-PLGA NP and free insulin comparing to their controls were 29.15 and 12.16%, respectively. These results support strongly the potential of insulin-loaded colloidal carriers for improved wound healing when delivered using dilatant hydrogel formulations.}, keywords = {Wound healing; PLGA nanoparticles; recombinant human insulin; Acute diabetes; Topical delivery}, year = {2018}, eissn = {2190-3948}, pages = {1053-1065} } @article{MTMT:27555398, title = {Protein delivery nanosystem of six-arm copolymer poly(epsilon-caprolactone)-poly(ethylene glycol) for long-term sustained release}, url = {https://m2.mtmt.hu/api/publication/27555398}, author = {Duan, Jianwei and Liu, Chao and Liang, Xiaoyu and Li, Xuanling and Chen, Youlu and Chen, Zuoguan and Wang, Xiaoli and Kong, Deling and Li, Yongjun and Yang, Jing}, doi = {10.2147/IJN.S161006}, journal-iso = {INT J NANOMED}, journal = {INTERNATIONAL JOURNAL OF NANOMEDICINE}, volume = {13}, unique-id = {27555398}, issn = {1176-9114}, year = {2018}, eissn = {1178-2013}, pages = {2743-2754} } @article{MTMT:30448505, title = {Optimization of PLGA formulation containing protein or peptide-based antigen: Recent advances}, url = {https://m2.mtmt.hu/api/publication/30448505}, author = {Hajavi, Jafar and Ebrahimian, Mahboubeh and Sankian, Mojtaba and Khakzad, Mohammad Reza and Hashemi, Maryam}, doi = {10.1002/jbm.a.36423}, journal-iso = {J BIOMED MATER RES A}, journal = {JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A}, volume = {106}, unique-id = {30448505}, issn = {1549-3296}, abstract = {Protein or peptide-based antigens are the most promising forms to generate custom protective immune responses for clinical applications. Over the last decades, poly(lactic-co-glycolic acid) (PLGA) as a biodegradable polymer has gained more attention for delivery of protein and peptide. Besides many appropriate characteristics, to improve its properties to overcome some obstacles such as release profile and it is important instability of antigen during both encapsulation and storage. Therefore, optimized procedures conditions require to be used to maintain the integrity of protein structure under several stress factors in formulation process. In this review article, the properties of PLGA particles, their preparation techniques and strategies for improvement of protein stability during encapsulation into PLGA, release from particle and storage as well as stabilization approaches were summarized. (c) 2018 Wiley Periodicals, Inc. J. Biomed. Mater. Res. Part A: 106A: 2540-2551, 2018}, keywords = {PROTEIN; Optimization; Formulation; PLGA; peptide antigens}, year = {2018}, eissn = {1552-4965}, pages = {2540-2551}, orcid-numbers = {Hashemi, Maryam/0000-0003-1549-4886} } @article{MTMT:30448504, title = {Preparation and application of flavor and fragrance capsules}, url = {https://m2.mtmt.hu/api/publication/30448504}, author = {He, Lei and Hu, Jing and Deng, Weijun}, doi = {10.1039/c8py00863a}, journal-iso = {POLYM CHEM-UK}, journal = {POLYMER CHEMISTRY}, volume = {9}, unique-id = {30448504}, issn = {1759-9962}, abstract = {Flavors and fragrances in special active materials are applied widely in daily life, which can bring pleasant olfactory and gustatory sensations. However, their many ingredients are chemically unstable and susceptible to deterioration and loss when the flavor and fragrance are exposed to oxygen, light and heat. Nano and micrometer size capsules with a hollow core domain and a shell can effectively protect the stability of the flavor and fragrance and control their release. The structures and properties of flavor and fragrance capsules can be interestingly tailored by choosing a variety of shell materials. In this review, we give a brief overview with regard to the different preparation methods of flavor and fragrance capsules based on the type of wall material, including polymeric, inorganic and polymeric-inorganic materials. Besides, the application of flavor and fragrance capsules in food, tobacco, care products, textiles, leather and paper is briefly summarized. Moreover, the development trends of flavor and fragrance capsules are prospected.}, year = {2018}, eissn = {1759-9954}, pages = {4926-4946} } @article{MTMT:30448503, title = {Preparation and characterization of bee venom-loaded PLGA particles for sustained release}, url = {https://m2.mtmt.hu/api/publication/30448503}, author = {Park, Min-Ho and Jun, Hye-Suk and Jeon, Jong-Woon and Park, Jin-Kyu and Lee, Bong-Joo and Suh, Guk-Hyun and Park, Jeong-Sook and Cho, Cheong-Weon}, doi = {10.1080/10837450.2016.1264415}, journal-iso = {PHARM DEV TECHNOL}, journal = {PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY}, volume = {23}, unique-id = {30448503}, issn = {1083-7450}, abstract = {Bee venom-loaded poly(lactic-co-glycolic acid) (PLGA) particles were prepared by double emulsion-solvent evaporation, and characterized for a sustained-release system. Factors such as the type of organic solvent, the amount of bee venom and PLGA, the type of PLGA, the type of polyvinyl alcohol, and the emulsification method were considered. Physicochemical properties, including the encapsulation efficiency, drug loading, particle size, zeta-potential and surface morphology were examined by Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction (XRD). The size of the bee venom-loaded PLGA particles was 500 nm (measured using sonication). Zeta-potentials of the bee venom-loaded PLGA particles were negative owing to the PLGA. FT-IR results demonstrated that the bee venom was completely encapsulated in the PLGA particles, indicated by the disappearance of the amine and amide peaks. In addition, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis indicated that the bee venom in the bee venom-loaded PLGA particles was intact. In vitro release of the bee venom from the bee venom-loaded PLGA particles showed a sustained-release profile over 1 month. Bee venom-loaded PLGA particles can help improve patients' quality of life by reducing the number of injections required.}, keywords = {PLGA; bee venom; Microparticle; sustained release}, year = {2018}, eissn = {1097-9867}, pages = {857-864}, orcid-numbers = {Park, Jeong-Sook/0000-0002-4081-213X; Cho, Cheong-Weon/0000-0001-8390-0132} } @article{MTMT:27555396, title = {A two-step synthesis for preparing metal microcapsules with a biodegradable polymer substrate}, url = {https://m2.mtmt.hu/api/publication/27555396}, author = {Tasker, Alison L and Puttick, Simon and Hitchcock, James and Cayre, Olivier J and Blakey, Idriss and Whittaker, Andrew K and Biggs, Simon}, doi = {10.1039/c8tb00348c}, journal-iso = {J MATER CHEM B}, journal = {JOURNAL OF MATERIALS CHEMISTRY B}, volume = {6}, unique-id = {27555396}, issn = {2050-750X}, year = {2018}, eissn = {2050-7518}, pages = {2151-2158}, orcid-numbers = {Biggs, Simon/0000-0002-8941-1222} } @article{MTMT:27331033, title = {Effect of formulation parameters on the size of PLGA nanoparticles encapsulating bovine serum albumin: a response surface methodology}, url = {https://m2.mtmt.hu/api/publication/27331033}, author = {Adebileje, Tajudeen and Valizadeh, Alireza and Amani, Amir}, doi = {10.22317/jcms.12201704}, journal-iso = {JOURNAL OF CONTEMPORARY MEDICAL SCIENCES}, journal = {JOURNAL OF CONTEMPORARY MEDICAL SCIENCES}, volume = {3}, unique-id = {27331033}, issn = {2413-0516}, year = {2017}, pages = {306-312} } @article{MTMT:26556331, title = {Calcium Stearate as an Effective Alternative to Poly(vinyl alcohol) in Poly-Lactic-co-Glycolic Acid Nanoparticles Synthesis}, url = {https://m2.mtmt.hu/api/publication/26556331}, author = {Cella, Claudia and Gerges, Irini and Milani, Paolo and Lenardi, Cristina and Argentiere, Simona}, doi = {10.1021/acs.biomac.6b01546}, journal-iso = {BIOMACROMOLECULES}, journal = {BIOMACROMOLECULES}, volume = {18}, unique-id = {26556331}, issn = {1525-7797}, year = {2017}, eissn = {1526-4602}, pages = {452-460}, orcid-numbers = {Cella, Claudia/0000-0002-9210-0775} } @article{MTMT:26380572, title = {Risk management and statistical multivariate analysis approach for design and optimization of satranidazole nanoparticles}, url = {https://m2.mtmt.hu/api/publication/26380572}, author = {Dhat, Shalaka and Pund, Swati and Kokare, Chandrakant and Sharma, Pankaj and Shrivastava, Birendra}, doi = {10.1016/j.ejps.2016.09.035}, journal-iso = {EUR J PHARM SCI}, journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES}, volume = {96}, unique-id = {26380572}, issn = {0928-0987}, year = {2017}, eissn = {1879-0720}, pages = {273-283} } @article{MTMT:26556332, title = {Facile and cost-effective synthesis of isocyanate microcapsules via polyvinyl alcohol-mediated interfacial polymerization and their application in self-healing materials}, url = {https://m2.mtmt.hu/api/publication/26556332}, author = {He, Zhenglong and Jiang, Shuai and Li, Qifeng and Wang, Junwei and Zhao, Yuhua and Kang, Maoqing}, doi = {10.1016/j.compscitech.2016.11.004}, journal-iso = {COMPOS SCI TECHNOL}, journal = {COMPOSITES SCIENCE AND TECHNOLOGY}, volume = {138}, unique-id = {26556332}, issn = {0266-3538}, year = {2017}, eissn = {1879-1050}, pages = {15-23} } @article{MTMT:26556330, title = {Enhanced effect of geldanamycin nanocomposite against breast cancer cells growing in vitro and as xenograft with vanquished normal cell toxicity}, url = {https://m2.mtmt.hu/api/publication/26556330}, author = {Prabhu, Suma and Ananthanarayanan, Preeta and Aziz, Sajida Kannangar and Rai, Sharada and Mutalik, Srinivas and Sadashiva, Satish Rao Bola}, doi = {10.1016/j.taap.2017.02.012}, journal-iso = {TOXICOL APPL PHARM}, journal = {TOXICOLOGY AND APPLIED PHARMACOLOGY}, volume = {320}, unique-id = {26556330}, issn = {0041-008X}, year = {2017}, eissn = {1096-0333}, pages = {60-72} } @article{MTMT:26022938, title = {Amine-modified poly(vinyl alcohol) as a novel surfactant to modulate size and surface charge of poly(lactide-co-glycolide) nanoparticles}, url = {https://m2.mtmt.hu/api/publication/26022938}, author = {Cella, Claudia and Martello, Federico and Ghisletti, Serena and Lenardi, Cristina and Milani, Paolo and Argentiere, Simona}, doi = {10.1002/pi.5122}, journal-iso = {POLYM INT}, journal = {POLYMER INTERNATIONAL}, volume = {65}, unique-id = {26022938}, issn = {0959-8103}, year = {2016}, eissn = {1097-0126}, pages = {792-797}, orcid-numbers = {Lenardi, Cristina/0000-0002-5522-6803} } @article{MTMT:25776105, title = {Tailoring sub-micron PLGA particle release profiles via centrifugal fractioning}, url = {https://m2.mtmt.hu/api/publication/25776105}, author = {Dutta, Dipankar and Salifu, Mariama and Sirianni, Rachael W and Stabenfeldt, Sarah E}, doi = {10.1002/jbm.a.35608}, journal-iso = {J BIOMED MATER RES A}, journal = {JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A}, volume = {104}, unique-id = {25776105}, issn = {1549-3296}, year = {2016}, eissn = {1552-4965}, pages = {688-696} } @article{MTMT:26238512, title = {In vitro IFN-alpha release from IFN-alpha- and pegylated IFN-alpha-loaded poly(lactic-co-glycolic acid) and pegylated poly(lactic-coglycolic acid) nanoparticles}, url = {https://m2.mtmt.hu/api/publication/26238512}, author = {Feczko, Tivadar and Fodor-Kardos, Andrea and Sivakumaran, Muttuswamy and Shubhra, Quazi Tanminul Haque}, doi = {10.2217/nnm-2016-0058}, journal-iso = {NANOMEDICINE-UK}, journal = {NANOMEDICINE}, volume = {11}, unique-id = {26238512}, issn = {1743-5889}, year = {2016}, eissn = {1748-6963}, pages = {2029-2034} } @article{MTMT:30448509, title = {Escherichia coli and Pseudomonas aeruginosa eradication by nano-penicillin G}, url = {https://m2.mtmt.hu/api/publication/30448509}, author = {Fernandes, Margarida M. and Ivanova, Kristina and Francesko, Antonio and Rivera, Diana and Torrent-Burgues, Juan and Gedanken, Aharon and Mendonza, Ernest and Tzanov, Tzanko}, doi = {10.1016/j.nano.2016.05.018}, journal-iso = {NANOMED: NANOTECHNOL}, journal = {NANOMEDICINE: NANOTECHNOLOGY BIOLOGY AND MEDICINE}, volume = {12}, unique-id = {30448509}, issn = {1549-9634}, abstract = {The transformation of penicillin G into nano/micro-sized spheres ( nanopenicillin) using sonochemical technology was explored as a novel tool for the eradication of Gram-negative bacteria and their biofilms. Known by its effectiveness only against Gram-positive microorganisms, the penicillin G spherization boosted the inhibition of the Gram-negative Pseudomonas aeruginosa 10-fold ( from 0.3 to 3.0 log-reduction) and additionally induced 1.2 log-reduction of Escherichia coli growth. The efficient penetration of the spheres within a Langmuir monolayer sustained the theory that nanopenicillin is able to cross the membrane and reach the periplasmic space in Gram-negative bacteria where they inhibit the beta-lactam targets: the transferases that build the bacteria cell wall. Moreover, it considerably suppressed the growth of both bacterial biofilms on a medically relevant polystyrene surface, leaving majority of the adhered cells dead compared to the treatment with the non-processed penicillin G. Importantly, nanopenicillin was found innocuous towards human fibroblasts at the antibacterial-effective concentrations. (C) 2016 Elsevier Inc. All rights reserved.}, keywords = {ANTIBACTERIAL; penicillin G; Sonochemistry; Antibiofilm; Nano/Microspheres; Nano-bio interactions}, year = {2016}, eissn = {1549-9642}, pages = {2061-2069}, orcid-numbers = {Ivanova, Kristina/0000-0001-9158-4088; Francesko, Antonio/0000-0002-7038-5087; Torrent-Burgues, Juan/0000-0002-4952-736X; Tzanov, Tzanko/0000-0002-8568-1110} } @article{MTMT:25795145, title = {Synthesis and Characterization of Inhalable Flavonoid Nanoparticle for Lung Cancer Cell Targeting}, url = {https://m2.mtmt.hu/api/publication/25795145}, author = {Lee, Wing-Hin and Loo, Ching-Yee and Ong, Hui-Xin and Traini, Daniela and Young, Paul M and Rohanizadeh, Ramin}, doi = {10.1166/jbn.2016.2162}, journal-iso = {J BIOMED NANOTECHNOL}, journal = {JOURNAL OF BIOMEDICAL NANOTECHNOLOGY}, volume = {12}, unique-id = {25795145}, issn = {1550-7033}, year = {2016}, eissn = {1550-7041}, pages = {371-386} } @article{MTMT:26380573, title = {The effect of surfactant chain length on the morphology of poly(methyl methacrylate) microcapsules for fragrance oil encapsulation}, url = {https://m2.mtmt.hu/api/publication/26380573}, author = {Tasker, Alison Louise and Hitchcock, James Paul and He, Ling and Baxter, Elaine Alice and Biggs, Simon and Cayre, Olivier Jean}, doi = {10.1016/j.jcis.2016.08.058}, journal-iso = {J COLLOID INTERF SCI}, journal = {JOURNAL OF COLLOID AND INTERFACE SCIENCE}, volume = {484}, unique-id = {26380573}, issn = {0021-9797}, year = {2016}, eissn = {1095-7103}, pages = {10-16} } @article{MTMT:26380574, title = {Hydrophilic nanoparticles packed in oral tablets can improve the plasma profile of short half-life hydrophobic drugs}, url = {https://m2.mtmt.hu/api/publication/26380574}, author = {Usman, Faisal and Javed, Ibrahim and Hussain, Syed Zajif and Ranjha, Nazar Muhammad and Hussain, Irshad}, doi = {10.1039/c6ra11799f}, journal-iso = {RSC ADV}, journal = {RSC ADVANCES}, volume = {6}, unique-id = {26380574}, issn = {2046-2069}, year = {2016}, eissn = {2046-2069}, pages = {94896-94904} } @article{MTMT:24789021, title = {A Multioptimization Approach to Assessment of Drug Delivery of PLGA Nanoparticles: Simultaneous Control of Particle Size and Release Behavior}, url = {https://m2.mtmt.hu/api/publication/24789021}, author = {Baghaei, Bahareh and Jafari, Seyed Hassan and Khonakdar, Hossein Ali and Saeb, Mohammad Reza and Wagenknecht, Udo and Heinrich, Gert}, doi = {10.1080/00914037.2014.996714}, journal-iso = {INT J POLYM MATER PO}, journal = {INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS}, volume = {64}, unique-id = {24789021}, issn = {0091-4037}, year = {2015}, eissn = {1563-535X}, pages = {641-652} } @article{MTMT:25310311, title = {Preparation of monodisperse aqueous microspheres containing high concentration of L-ascorbic acid by microchannel emulsification}, url = {https://m2.mtmt.hu/api/publication/25310311}, author = {Khalid, Nauman and Kobayashi, Isao and Neves, Marcos A and Uemura, Kunihiko and Nakajima, Mitsutoshi and Nabetani, Hiroshi}, doi = {10.3109/02652048.2015.1065919}, journal-iso = {J MICROENCAPSUL}, journal = {JOURNAL OF MICROENCAPSULATION}, volume = {32}, unique-id = {25310311}, issn = {0265-2048}, year = {2015}, eissn = {1464-5246}, pages = {570-577} } @article{MTMT:26694752, title = {Bone Regeneration from PLGA Micro-Nanoparticles}, url = {https://m2.mtmt.hu/api/publication/26694752}, author = {Ortega-Oller, Inmaculada and Padial-Molina, Miguel and Galindo-Moreno, Pablo and O'Valle, Francisco and Belen, Jodar-Reyes Ana and Manuel, Peula-Garcia Jose}, doi = {10.1155/2015/415289}, journal-iso = {BIOMED RES INT}, journal = {BIOMED RESEARCH INTERNATIONAL}, volume = {2015}, unique-id = {26694752}, issn = {2314-6133}, year = {2015}, eissn = {2314-6141}, orcid-numbers = {Padial-Molina, Miguel/0000-0001-6222-1341; Galindo-Moreno, Pablo/0000-0002-6614-6470} } @article{MTMT:24789020, title = {Design of experiments for the development of poly(D,L-lactide-co-glycolide) nanoparticles loaded with Uncaria tomentosa}, url = {https://m2.mtmt.hu/api/publication/24789020}, author = {Ribeiro, Ana Ferreira and Garruth, Ferreira Carina Torres and dos, Santos Juliana Fernandes and Cabral, Lucio Mendes and de Sousa, Valeria Pereira}, doi = {10.1007/s11051-015-2883-y}, journal-iso = {J NANOPART RES}, journal = {JOURNAL OF NANOPARTICLE RESEARCH}, volume = {17}, unique-id = {24789020}, issn = {1388-0764}, year = {2015}, eissn = {1572-896X} } @article{MTMT:25081730, title = {Effect of the surface modification, size, and shape on cellular uptake of nanoparticles}, url = {https://m2.mtmt.hu/api/publication/25081730}, author = {Salatin, Sara and Dizaj, Solmaz Maleki and Khosroushahi, Ahmad Yari}, doi = {10.1002/cbin.10459}, journal-iso = {CELL BIOL INT}, journal = {CELL BIOLOGY INTERNATIONAL}, volume = {39}, unique-id = {25081730}, issn = {1065-6995}, year = {2015}, eissn = {1095-8355}, pages = {881-890} } @article{MTMT:24535898, title = {Novel Thermosensitive Hydrogel Composites Based on Poly(D,L-lactide-co-glycolide) Nanoparticles Embedded in Poly(N-isopropyl acrylamide) with Sustained Drug-Release Behavior}, url = {https://m2.mtmt.hu/api/publication/24535898}, author = {Baghaei, B and Jafari, SH and Khonakdar, HA and Wagenknecht, U and Heinrich, G}, doi = {10.1002/app.40625}, journal-iso = {J APPL POLYM SCI}, journal = {JOURNAL OF APPLIED POLYMER SCIENCE}, volume = {131}, unique-id = {24535898}, issn = {0021-8995}, year = {2014}, eissn = {1097-4628} } @article{MTMT:24535899, title = {Encapsulation of immunoglobulin G by solid-in-oil-in-water: Effect of process parameters on microsphere properties}, url = {https://m2.mtmt.hu/api/publication/24535899}, author = {Marquette, S and Peerboom, C and Yates, A and Denis, L and Goole, J and Amighi, K}, doi = {10.1016/j.ejpb.2013.10.013}, journal-iso = {EUR J PHARM BIOPHARM}, journal = {EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS}, volume = {86}, unique-id = {24535899}, issn = {0939-6411}, year = {2014}, eissn = {1873-3441}, pages = {393-403} } @article{MTMT:24584069, title = {Development of midazolam loaded poly(D, L-lactide-co-glycolic acid) nanoparticles for treatment of status epilepticus}, url = {https://m2.mtmt.hu/api/publication/24584069}, author = {Sharma, D and Gabrani, R and Sharma, S K and Ali, J and Dang, S}, doi = {10.1166/as1.2014.5520}, journal-iso = {RES PHARM SCI}, journal = {RESEARCH IN PHARMACEUTICAL SCIENCES}, volume = {9}, unique-id = {24584069}, issn = {1735-5362}, year = {2014}, eissn = {1735-9414}, pages = {407-420} } @article{MTMT:2568095, title = {Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size.}, url = {https://m2.mtmt.hu/api/publication/2568095}, author = {Shubhra, Quazi Tanminul Haque and Fodorné Kardos, Andrea and Feczkó, Tivadar and Mackova, H and Horák, D and Tóth, Judit and Dósa, György and Gyenis, János}, doi = {10.3109/02652048.2013.814729}, journal-iso = {J MICROENCAPSUL}, journal = {JOURNAL OF MICROENCAPSULATION}, volume = {31}, unique-id = {2568095}, issn = {0265-2048}, year = {2014}, eissn = {1464-5246}, pages = {147-155}, orcid-numbers = {Dósa, György/0000-0002-4909-6694; Gyenis, János/0000-0001-5928-0535} } @article{MTMT:2568125, title = {Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part II. Effect of process variables on protein model drug encapsulation efficiency.}, url = {https://m2.mtmt.hu/api/publication/2568125}, author = {Shubhra, Quazi Tanminul Haque and Feczkó, Tivadar and Fodorné Kardos, Andrea and Mackova, H and Horák, D and Tóth, Judit and Dósa, György and Gyenis, János}, doi = {10.3109/02652048.2013.814730}, journal-iso = {J MICROENCAPSUL}, journal = {JOURNAL OF MICROENCAPSULATION}, volume = {31}, unique-id = {2568125}, issn = {0265-2048}, year = {2014}, eissn = {1464-5246}, pages = {156-165}, orcid-numbers = {Dósa, György/0000-0002-4909-6694; Gyenis, János/0000-0001-5928-0535} } @article{MTMT:24535897, title = {Poloxamers for Surface Modification of Hydrophobic Drug Carriers and Their Effects on Drug Delivery}, url = {https://m2.mtmt.hu/api/publication/24535897}, author = {Shubhra, QTH and Toth, J and Gyenis, J and Feczko, T}, doi = {10.1080/15583724.2013.862544}, journal-iso = {POLYM REV}, journal = {POLYMER REVIEWS}, volume = {54}, unique-id = {24535897}, issn = {1558-3724}, year = {2014}, eissn = {1558-3716}, pages = {112-138} } @article{MTMT:2822838, title = {Surface modification of HSA containing magnetic PLGA nanoparticles by poloxamer to decrease plasma protein adsorption}, url = {https://m2.mtmt.hu/api/publication/2822838}, author = {Shubhra, Quazi Tanminul Haque and Tóth, Judit and Gyenis, János and Feczkó, Tivadar}, doi = {10.1016/j.colsurfb.2014.07.025}, journal-iso = {COLLOID SURFACE B}, journal = {COLLOIDS AND SURFACES B: BIOINTERFACES}, volume = {122}, unique-id = {2822838}, issn = {0927-7765}, year = {2014}, eissn = {1873-4367}, pages = {529-536}, orcid-numbers = {Gyenis, János/0000-0001-5928-0535} } @article{MTMT:23285780, title = {Fabrication of protein-loaded PLGA nanoparticles: effect of selected formulation variables on particle size and release profile}, url = {https://m2.mtmt.hu/api/publication/23285780}, author = {Azizi, M and Farahmandghavi, F and Joghataei, M and Zandi, M and Imani, M and Bakhtiary, M and Dorkoosh, FA and Ghazizadeh, F}, doi = {10.1007/s10965-013-0110-z}, journal-iso = {J POLYM RES}, journal = {JOURNAL OF POLYMER RESEARCH}, volume = {20}, unique-id = {23285780}, issn = {1022-9760}, year = {2013}, eissn = {1572-8935} } @article{MTMT:2417666, title = {Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery}, url = {https://m2.mtmt.hu/api/publication/2417666}, author = {Shubhra, Quazi Tanminul Haque and Mackova, H and Horak, D and Fodorné Kardos, Andrea and Tóth, Judit and Gyenis, János and Feczkó, Tivadar}, doi = {10.1515/epoly.2013.13.1.310}, journal-iso = {E-POLYMERS}, journal = {E-POLYMERS}, volume = {13}, unique-id = {2417666}, issn = {1618-7229}, year = {2013}, eissn = {1618-7229}, pages = {310-318}, orcid-numbers = {Gyenis, János/0000-0001-5928-0535} } @article{MTMT:23285779, title = {MAPLE DEPOSITION OF PLGA MICRO- AND NANOPARTICLES EMBEDDED INTO POLYMERIC COATINGS}, url = {https://m2.mtmt.hu/api/publication/23285779}, author = {Socol, G and Preda, N and Socol, M and Sima, L and Luculescu, CR and Sima, F and Miroiu, M and Axente, E and Visan, A and Stefan, N and Cristescu, R and Dorcioman, G and Stanculescu, A and Radulescu, L and Mihailescu, IN}, journal-iso = {DIG J NANOMATER BIOS}, journal = {DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES}, volume = {8}, unique-id = {23285779}, issn = {1842-3582}, year = {2013}, eissn = {1842-3582}, pages = {621-630} } @article{MTMT:22351193, title = {Self nanoprecipitating preconcentrate of tamoxifen citrate for enhanced bioavailability}, url = {https://m2.mtmt.hu/api/publication/22351193}, author = {Kapse, SV and Gaikwad, RV and Samad, A and Devarajan, PV}, doi = {10.1016/j.ijpharm.2012.02.042}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {429}, unique-id = {22351193}, issn = {0378-5173}, year = {2012}, eissn = {1873-3476}, pages = {104-112} } @article{MTMT:22781129, title = {Dissolution Enhancement and Characterization of Nimodipine Solid Dispersions with Poloxamer 407 or PEG 6000}, url = {https://m2.mtmt.hu/api/publication/22781129}, author = {Kreidel, RN and Duque, MD and Serra, CHR and Velasco, MVR and Baby, AR and Kaneko, TM and Consiglieri, VO}, doi = {10.1080/01932691.2011.605663}, journal-iso = {J DISPER SCI TECHNOL}, journal = {JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY}, volume = {33}, unique-id = {22781129}, issn = {0193-2691}, year = {2012}, eissn = {1532-2351}, pages = {1354-1359} } @article{MTMT:22516696, title = {Preparation and characterization of cationic curcumin nanoparticles for improvement of cellular uptake}, url = {https://m2.mtmt.hu/api/publication/22516696}, author = {Liu, J and Xu, L and Liu, C and Zhang, D and Wang, S and Deng, Z and Lou, W and Xu, H and Bai, Q and Ma, J}, doi = {10.1016/j.carbpol.2012.04.036}, journal-iso = {CARBOHYD POLYM}, journal = {CARBOHYDRATE POLYMERS}, volume = {90}, unique-id = {22516696}, issn = {0144-8617}, year = {2012}, eissn = {1879-1344}, pages = {16-22} } @article{MTMT:22854857, title = {Biodegradable PLGA-b-PEG polymeric nanoparticles: Synthesis, properties, and nanomedical applications as drug delivery system}, url = {https://m2.mtmt.hu/api/publication/22854857}, author = {Locatelli, E and Franchini, MC}, doi = {10.1007/s11051-012-1316-4}, journal-iso = {J NANOPART RES}, journal = {JOURNAL OF NANOPARTICLE RESEARCH}, volume = {14}, unique-id = {22854857}, issn = {1388-0764}, year = {2012}, eissn = {1572-896X} } @article{MTMT:22386236, title = {Evaluation of subcutaneous forms in the improvement of pharmacokinetic profile of warfarin}, url = {https://m2.mtmt.hu/api/publication/22386236}, author = {Scala-Bertola, J and Javot, L and Camargo, JA and Bonneaux, F and Lecompte, T and Maincent, P and Sapin, A}, doi = {10.1016/j.ijpharm.2012.03.053}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {431}, unique-id = {22386236}, issn = {0378-5173}, year = {2012}, eissn = {1873-3476}, pages = {33-38} } @article{MTMT:22516751, title = {A one-step process in preparation of cationic nanoparticles with poly(lactide-co-glycolide)-containing polyethylenimine gives efficient gene delivery}, url = {https://m2.mtmt.hu/api/publication/22516751}, author = {Shau, Min Da and Shih, Mei Fen and Lin, Chi Cheng and et, al}, doi = {10.1016/j.ejps.2012.04.006}, journal-iso = {EUR J PHARM SCI}, journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES}, volume = {46}, unique-id = {22516751}, issn = {0928-0987}, year = {2012}, eissn = {1879-0720}, pages = {522-529} } @article{MTMT:22268607, title = {Protein microspheres as suitable devices for piroxicam release}, url = {https://m2.mtmt.hu/api/publication/22268607}, author = {Silva, R and Ferreira, H and Carvalho, AC and Gomes, AC and Cavaco-Paulo, A}, doi = {10.1016/j.colsurfb.2011.11.050}, journal-iso = {COLLOID SURFACE B}, journal = {COLLOIDS AND SURFACES B: BIOINTERFACES}, volume = {92}, unique-id = {22268607}, issn = {0927-7765}, year = {2012}, eissn = {1873-4367}, pages = {277-285} } @article{MTMT:21521719, title = {Performance of biodegradable microcapsules of poly(butylene succinate), poly(butylene succinate-co-adipate) and poly(butylene terephthalate-co-adipate) as drug encapsulation systems}, url = {https://m2.mtmt.hu/api/publication/21521719}, author = {Brunner, CT and Baran, ET and Pinho, ED and Reis, RL and Neves, NM}, doi = {10.1016/j.colsurfb.2011.02.005}, journal-iso = {COLLOID SURFACE B}, journal = {COLLOIDS AND SURFACES B: BIOINTERFACES}, volume = {84}, unique-id = {21521719}, issn = {0927-7765}, year = {2011}, eissn = {1873-4367}, pages = {498-507} } @article{MTMT:1671122, title = {Influence of process conditions on the mean size of PLGA nanoparticles}, url = {https://m2.mtmt.hu/api/publication/1671122}, author = {Feczkó, Tivadar and Tóth, Judit and Dósa, György and Gyenis, János}, doi = {10.1016/j.cep.2011.05.006}, journal-iso = {CHEM ENG PROCESS}, journal = {CHEMICAL ENGINEERING AND PROCESSING}, volume = {50}, unique-id = {1671122}, issn = {0255-2701}, year = {2011}, eissn = {1873-3204}, pages = {846-853}, orcid-numbers = {Dósa, György/0000-0002-4909-6694; Gyenis, János/0000-0001-5928-0535} } @article{MTMT:1671149, title = {Optimization of protein encapsulation in PLGA nanoparticles}, url = {https://m2.mtmt.hu/api/publication/1671149}, author = {Feczkó, Tivadar and Tóth, Judit and Dósa, György and Gyenis, János}, doi = {10.1016/j.cep.2011.06.008}, journal-iso = {CHEM ENG PROCESS}, journal = {CHEMICAL ENGINEERING AND PROCESSING}, volume = {50}, unique-id = {1671149}, issn = {0255-2701}, year = {2011}, eissn = {1873-3204}, pages = {757-765}, orcid-numbers = {Dósa, György/0000-0002-4909-6694; Gyenis, János/0000-0001-5928-0535} } @article{MTMT:21803162, title = {Effects of the total replacement of fish-based diet with plant-based diet on the hepatic transcriptome of two European sea bass (Dicentrarchus labrax) half-sibfamilies showing different growth rates with the plant-based diet}, url = {https://m2.mtmt.hu/api/publication/21803162}, author = {Geay, F and Ferraresso, S and Zambonino-Infante, JL and Bargelloni, L and Quentel, C and Vandeputte, M and Kaushik, S and Cahu, CL and Mazurais, D}, doi = {10.1186/1471-2164-12-522}, journal-iso = {BMC GENOMICS}, journal = {BMC GENOMICS}, volume = {12}, unique-id = {21803162}, issn = {1471-2164}, year = {2011}, eissn = {1471-2164} } @article{MTMT:21521688, title = {A "tool box" for rational design of degradable controlled release formulations}, url = {https://m2.mtmt.hu/api/publication/21521688}, author = {Rothstein, SN and Little, SR}, doi = {10.1039/c0jm01668c}, journal-iso = {J MATER CHEM}, journal = {JOURNAL OF MATERIALS CHEMISTRY}, volume = {21}, unique-id = {21521688}, issn = {0959-9428}, year = {2011}, eissn = {1364-5501}, pages = {29-39} } @article{MTMT:21713474, title = {Sonoproduction of Liposomes and Protein Particles as Templates for Delivery Purposes}, url = {https://m2.mtmt.hu/api/publication/21713474}, author = {Silva, R and Ferreira, H and Cavaco-Paulo, A}, doi = {10.1021/bm200658b}, journal-iso = {BIOMACROMOLECULES}, journal = {BIOMACROMOLECULES}, volume = {12}, unique-id = {21713474}, issn = {1525-7797}, year = {2011}, eissn = {1526-4602}, pages = {3353-3368} } @article{MTMT:22516670, title = {The influence of PVA on the size of oligoester anoparticles prepared by the emulsion solvent distribution method}, url = {https://m2.mtmt.hu/api/publication/22516670}, author = {Valentová, E and Snejdrová, E and Dittrich, M}, journal-iso = {CESKA A SLOVENSKA FARMACIE}, journal = {CESKA A SLOVENSKA FARMACIE}, volume = {60}, unique-id = {22516670}, issn = {1210-7816}, year = {2011}, pages = {193-199} } @article{MTMT:22516688, title = {Controlled release of methotrexate using alpha-lactalbumin microparticles}, url = {https://m2.mtmt.hu/api/publication/22516688}, author = {Vijayaragavan, S and Vino, S and Lokesh, K R and Ghosh, A R and Jayaraman, G}, volume = {381}, unique-id = {22516688}, year = {2011}, pages = {39-44} } @article{MTMT:32694101, title = {Controlled release of methotrexate using alpha-lactalbumin microparticles}, url = {https://m2.mtmt.hu/api/publication/32694101}, author = {Vijayaragavan, S. and Vino, S. and Lokesh, K.R. and Ghosh, A.R. and Jayaraman, G.}, journal-iso = {J INT PHARMACEUT RES}, journal = {JOURNAL OF INTERNATIONAL PHARMACEUTICAL RESEARCH}, volume = {3}, unique-id = {32694101}, issn = {1674-0440}, abstract = {Microparticles of α -lactalbumin, in the free and methotrexate encapsulated forms were prepared by emulsifying an aqueous solution of α -lactalbumin in 1% ethylcellulose in chloroform at 4°C. The particles were further stabilized by cross linking with glutaraldehyde. The size of the particles was found to be in the range of 0.5 to 2μm, with an average size of 1 μm. Both free and methotrexate encapsulated α -lactalbumin microparticles were analyzed by differential scanning calorimetry and X-ray diffraction studies. The rate of drug release was investigated by in vitro dissolution studies using UV spectroscopy. The results indicate that these α -lactalbumin microparticles are capable of controlled and sustained release of methotrexate up to a maximum time of 36 h in PBS at pH 7.4. The study introduces α -lactalbumin as a novel drug carrier and its potential to combat the failure of free methotrexate administration.}, keywords = {ARTICLE; WATER; differential scanning calorimetry; controlled study; in vitro study; drug delivery system; microencapsulation; drug stability; drug solubility; particle size; drug carrier; Steric stabilization; METHOTREXATE; METHOTREXATE; controlled release; drug dosage form comparison; sustained drug release; X ray diffraction; controlled drug release; phosphate buffered saline; CHLOROFORM; glutaraldehyde; ultraviolet spectroscopy; cross linking; pH measurement; milk protein; Microparticles; ethyl cellulose; SOLUBLE DRUGS; alpha lactalbumin; α-lactalbumin(ala)}, year = {2011}, eissn = {0975-2366}, pages = {39-44} } @article{MTMT:22516672, title = {Latest research progress of drug stability and release of PLGA microspheres}, url = {https://m2.mtmt.hu/api/publication/22516672}, author = {Wang, M -B and Feng, Q -L and She, Z -D and Tan, R -W}, journal-iso = {J OF FUNCTIONAL METERIALS}, journal = {JOURNAL OF FUNCTIONAL MATERIALS}, volume = {42}, unique-id = {22516672}, issn = {1001-9731}, year = {2011}, pages = {591-595} } @article{MTMT:21782011, title = {Characterisation and stability studies of a hydrophilic decapeptide in different adjuvant drug delivery systems: A comparative study of PLGA nanoparticles versus chitosan-dextran sulphate microparticles versus DOTAP-liposomes}, url = {https://m2.mtmt.hu/api/publication/21782011}, author = {Wieber, A and Selzer, T and Kreuter, J}, doi = {10.1016/j.ijpharm.2011.09.011}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {421}, unique-id = {21782011}, issn = {0378-5173}, year = {2011}, eissn = {1873-3476}, pages = {151-159} } @article{MTMT:21713473, title = {The Imprinting Induce-Fit Model of Specific Rebinding of Macromolecularly Imprinted Polymer Microspheres}, url = {https://m2.mtmt.hu/api/publication/21713473}, author = {Ying, XG and Cheng, GX and Li, X}, doi = {10.1002/app.34263}, journal-iso = {J APPL POLYM SCI}, journal = {JOURNAL OF APPLIED POLYMER SCIENCE}, volume = {122}, unique-id = {21713473}, issn = {0021-8995}, year = {2011}, eissn = {1097-4628}, pages = {1847-1856} } @inbook{MTMT:1400917, title = {Multiple emulsion - Solvent evaporation technique}, url = {https://m2.mtmt.hu/api/publication/1400917}, author = {Feczkó, Tivadar}, booktitle = {Colloids in Biotechnology}, doi = {10.1201/EBK1439830802}, unique-id = {1400917}, year = {2010}, pages = {349-380} } @article{MTMT:1377417, title = {Preparation and characterization of ethylcellulose-based microcapsules for sustaining release of a model fragrance}, url = {https://m2.mtmt.hu/api/publication/1377417}, author = {Feczkó, Tivadar and Kohol, V and Voncina, B}, doi = {10.1007/s13233-010-0701-z}, journal-iso = {MACROMOL RES}, journal = {MACROMOLECULAR RESEARCH}, volume = {18}, unique-id = {1377417}, issn = {1598-5032}, year = {2010}, eissn = {2092-7673}, pages = {636-640} } @article{MTMT:20914287, title = {Preparation and characterization of a polymeric (PLGA) nanoparticulate drug delivery system with simultaneous incorporation of chemotherapeutic and thermo-optical agents}, url = {https://m2.mtmt.hu/api/publication/20914287}, author = {Manchanda, R and Fernandez-Fernandez, A and Nagesetti, A and McGoron, A J}, journal-iso = {COLLOID SURFACE B}, journal = {COLLOIDS AND SURFACES B: BIOINTERFACES}, volume = {75}, unique-id = {20914287}, issn = {0927-7765}, year = {2010}, eissn = {1873-4367}, pages = {260-267} } @article{MTMT:20914283, title = {Surface Modification of PLGA Particles: The Interplay between Stabilizer, Ligand Size, and Hydrophobic Interactions}, url = {https://m2.mtmt.hu/api/publication/20914283}, author = {Ratzinger, G and Langer, U and Neutsch, L and et, al}, doi = {10.1021/la902602z}, journal-iso = {LANGMUIR}, journal = {LANGMUIR}, volume = {26}, unique-id = {20914283}, issn = {0743-7463}, year = {2010}, eissn = {1520-5827}, pages = {1855-1859} } @article{MTMT:21803163, title = {Modelling in systems biology, neurology and pharmacy}, url = {https://m2.mtmt.hu/api/publication/21803163}, author = {Belic, A}, doi = {10.1080/13873950903375304}, journal-iso = {MATH COMP MODEL DYN}, journal = {MATHEMATICAL AND COMPUTER MODELLING OF DYNAMICAL SYSTEMS}, volume = {15}, unique-id = {21803163}, issn = {1387-3954}, year = {2009}, eissn = {1744-5051}, pages = {479-491} } @article{MTMT:20507620, title = {Preparation of ultrafine fenofibrate powder by solidification process from emulsion}, url = {https://m2.mtmt.hu/api/publication/20507620}, author = {Huang, Q-P and Wang, J-X and Zhang, Z-B and Shen, Z-G and Chen, J-F and Yun, J}, doi = {10.1016/j.ijpharm.2008.10.015}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {368}, unique-id = {20507620}, issn = {0378-5173}, year = {2009}, eissn = {1873-3476}, pages = {160-164} } @mastersthesis{MTMT:22516555, title = {Encapsulation and Controlled Release of Pharmaceuticals with biodegradable Hyperbranched Polyesters}, url = {https://m2.mtmt.hu/api/publication/22516555}, author = {Mallepally, R R}, unique-id = {22516555}, year = {2009} } @misc{MTMT:22516643, title = {Evaluation of effective parameters on fabrication of BSA nanoparticles. Nature Precedings}, url = {https://m2.mtmt.hu/api/publication/22516643}, author = {Rahimnejad, M and Najafpour, G and Jahanshahi, M}, unique-id = {22516643}, year = {2009} } @article{MTMT:20914279, title = {Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins}, url = {https://m2.mtmt.hu/api/publication/20914279}, author = {Stevanovic, M and Uskokovic, D}, doi = {10.2174/157341309787314566}, journal-iso = {CURR NANOSCI}, journal = {CURRENT NANOSCIENCE}, volume = {5}, unique-id = {20914279}, issn = {1573-4137}, year = {2009}, eissn = {1875-6786}, pages = {1-14} } @article{MTMT:21803164, title = {Towards Identification of Gene Interaction Networks of Human Cholesterol Biosynthesis (vol 55, pg 396, 2008)}, url = {https://m2.mtmt.hu/api/publication/21803164}, author = {Juvan, P and Rezen, T and Rozman, D and Monostory, K and Pascussi, J and Belic, A}, journal-iso = {ACTA CHIM SLOV}, journal = {ACTA CHIMICA SLOVENICA}, volume = {55}, unique-id = {21803164}, issn = {1318-0207}, year = {2008}, eissn = {1580-3155}, pages = {688-688} } @article{MTMT:20913982, title = {Preparation and characterization of folate-mediated poly (lactic-co-glycolic) acid nanoparticles}, url = {https://m2.mtmt.hu/api/publication/20913982}, author = {Ling, Y and Huang, Y-S and Liang, C-Y and Li, X-M}, volume = {12}, unique-id = {20913982}, year = {2008}, pages = {7049-7052} } @article{MTMT:20913977, title = {Research progress in poly (lactic-co-glycolic acid) nanoparticles}, url = {https://m2.mtmt.hu/api/publication/20913977}, author = {Ling, Y and Huang, Y-S and Liang, C-Y}, volume = {12}, unique-id = {20913977}, year = {2008}, pages = {1899-1902} }