@article{MTMT:30651282,
	author = {Ghaderi, Amir and Bussu, Anna and Tsang, Catherine and Jafarnejad, Sadegh},
	doi = {10.1007/s00228-018-2595-1},
	title = {Effect of N-acetyl cysteine (NAC) supplementation on positive and negative syndrome scale in schizophrenia: a systematic review and meta-analysis of randomised controlled trials},
	journal-iso = {EUR J CLIN PHARMACOL},
	journal = {EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY},
	volume = {75},
	unique-id = {30651282},
	issn = {0031-6970},
	abstract = {ObjectiveTo conduct a systematic review and meta-analysis of published randomised controlled trials on the efficacy of NAC supplementation on positive and negative syndrome scale in schizophrenia.MethodsA meta-analysis was conducted, and studies were identified by a search of electronic databases from inception to May 2018. Combined and stratified analyses were used.ResultsSeven trials were identified, and data from n=447 participants were included. Pooled analysis showed improvement of positive and negative syndrome scale following NAC treatment compared with placebo, for total (SMB=-0.96) [95% CI -1.69, -0.24; P=0.009], general (SMB=-1.04) [95% CI -1.80, -0.27; P=0.008] and negative (SMB=-0.73) [95% CI -1.29, -0.17; P=0.01] scores, respectively. Significant heterogeneity was found, and subgroup analysis showed significant reductions in studies with a treatment duration of 24weeks, with a considerable effect size on total, general, and negative scores (Total SMD=-0.83; General SMD=-0.67; Negative SMD=-1.09) following NAC.ConclusionsNAC improved all aspects of positive and negative syndrome scale in schizophrenic populations and may be more efficacious with treatment durations up to 24weeks.},
	keywords = {SCHIZOPHRENIA; Meta-analysis; PANSS; N-acetyl cysteine},
	year = {2019},
	eissn = {1432-1041},
	pages = {289-301}
}

@article{MTMT:30762602,
	author = {Moghadas, M. and Essa, M.M. and Ba-Omar, T. and Al-Shehi, A. and Qoronfeh, M.W. and Eltayeb, E.A. and Guillemin, G.J. and Manivasagam, T. and Justin-Thenmozhi, A. and Al-Bulushi, B.S. and Al-Adawi, S. and Edalatmanesh, M.A.},
	doi = {10.2741/4720},
	title = {Antioxidant therapies in attention deficit hyperactivity disorder},
	journal-iso = {FRONT BIOSCI-LANDMRK},
	journal = {FRONTIERS IN BIOSCIENCE-LANDMARK},
	volume = {24},
	unique-id = {30762602},
	issn = {1093-9946},
	abstract = {Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder among children and adults. Impulsivity, inattention, and hyperactivity are hallmark of ADHD. While ADHD is not on the autism spectrum, they are related in several ways as they have some overlapping symptoms. The pathogenesis of ADHD has so far remained enigmatic, however, there is some evidence suggesting critical association among ADHD and the level of oxidative stress which trigger cell membrane damage, changes in inner structure and function of proteins, as well as structural damage to DNA which eventually culminate into development of ADHD. Although stimulants as well as some classes of non-stimulants are used to ameliorate symptom of ADHD, various adverse effects have been associated with such compounds. To date, treatment of ADHD is done with a combination of medications, behavior modifications, psycho-education, family therapy and life-style changes. The American Academy of Pediatrics officially promote stimulant medications and/or behavior therapy as 'first line of therapy'. In addition to the presently therapeutic armamentarium, evidences are emerging on relevancy of natural products. There has been an interest on the therapeutic role of antioxidants in the treatment of ADHD. The present review aims to highlight the beneficiary role played by different antioxidants in mitigating the symptoms of ADHD. © 2019 Frontiers in Bioscience. All Rights Reserved.},
	keywords = {Adult; Adult; Humans; PATHOPHYSIOLOGY; ANTIOXIDANTS; ANTIOXIDANTS; review; human; OXIDATION; Child; Child; Risk Factors; physiology; risk factor; GLUTATHIONE; GLUTATHIONE; ANTIOXIDANT; ascorbic acid; ascorbic acid; Attention Deficit Disorder with Hyperactivity; attention deficit disorder; attention deficit hyperactivity disorder; ADHD; Antioxidant therapy; Biological Products; biological product; Oxidative stress; Oxidative stress; Oxidative stress},
	year = {2019},
	eissn = {1093-4715},
	pages = {313-333}
}

@article{MTMT:30895641,
	author = {Adil, Mohammad and Amin, Syed Suhail and Mohtashim, Mohd},
	doi = {10.4103/ijdvl.IJDVL_33_18},
	title = {N-acetylcysteine in dermatology},
	journal-iso = {INDIAN J DERMATOL VE},
	journal = {INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY},
	volume = {84},
	unique-id = {30895641},
	issn = {0378-6323},
	abstract = {N-acetylcysteine is a mucolytic drug which is commonly used as an antidote for acetaminophen toxicity. It is a thiol compound, which acts as a donor of cysteine, leading to replenishment of glutathione and thus acts as an antioxidant. It also has anti-inflammatory effects, alters the levels of neurotransmitters, inhibits proliferation of fibroblasts and keratinocytes and causes vasodilatation. Due to these actions, n-acetylcysteine has found use in several dermatologic conditions in systemic and topical form. The drug has been used as an adjuvant in the management of conditions such as toxic epidermal necrolysis, drug hypersensitivity syndrome, trichotillomania, skin picking disorders and onychotillomania, ichthyoses, contact dermatitis, atopic dermatitis, melasma, pseudoporphyria, connective tissue diseases, wound healing and alopecia. It also has a role in protection from radiation-induced skin damage including photo-ageing, photocarcinogenesis and radiation dermatitis. Most indications in dermatology are supported by case reports, small case series and small trials. Higher quality of evidence is needed for its wider use. The drug is cheap and is generally safe with few adverse effects. Thus a greater role is possible for use of n-acetylcysteine in various skin conditions. This review explores the various uses of n-acetylcysteine in the field of dermatology, the evidence supporting the same, the possible mechanisms of action and the adverse effects of the drug.},
	keywords = {ANTIOXIDANT; N-acetylcysteine; Drug Reaction; trichotillomania},
	year = {2018},
	eissn = {0973-3922},
	pages = {652-659},
	orcid-numbers = {Adil, Mohammad/0000-0002-8697-1451}
}

@article{MTMT:27553146,
	author = {Bernhardt, Liegelin Kavitha and Bairy, K Lakshminarayana and Madhyastha, Sampath},
	doi = {10.3390/brainsci8070120},
	title = {Neuroprotective Role of N-acetylcysteine against Learning Deficits and Altered Brain Neurotransmitters in Rat Pups Subjected to Prenatal Stress},
	journal-iso = {BRAIN SCI},
	journal = {BRAIN SCIENCES},
	volume = {8},
	unique-id = {27553146},
	issn = {2076-3425},
	year = {2018},
	eissn = {2976-3425}
}

@article{MTMT:27341383,
	author = {Sepehrmanesh, Zahra and Heidary, Mahsa and Akasheh, Negar and Akbari, Hossein and Heidary, Mahshid},
	doi = {10.1016/j.pnpbp.2017.11.001},
	title = {Therapeutic effect of adjunctive N-acetyl cysteine (NAC) on symptoms of chronic schizophrenia: A double-blind, randomized clinical trial},
	journal-iso = {PROG NEURO-PSYCHOPHARMACOL BIOL PSYCHIATR},
	journal = {PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY},
	volume = {82},
	unique-id = {27341383},
	issn = {0278-5846},
	year = {2018},
	eissn = {1878-4216},
	pages = {289-296}
}

@article{MTMT:27071387,
	author = {Aguiar, Gean Pablo S and Marcon, Matheus and Mocelin, Ricieri and Herrmann, Ana P and Chaves, Lorenzo M P C and Piato, Angelo L and Lanza, Marcelo and Vladimir, Oliveira J},
	doi = {10.1016/j.supflu.2017.06.010},
	title = {Micronization of N-acetylcysteine by supercritical fluid: Evaluation of in vitro and in vivo biological activity},
	journal-iso = {J SUPERCRIT FLUID},
	journal = {JOURNAL OF SUPERCRITICAL FLUIDS},
	volume = {130},
	unique-id = {27071387},
	issn = {0896-8446},
	year = {2017},
	pages = {282-291},
	orcid-numbers = {Marcon, Matheus/0000-0002-1486-688X}
}

@article{MTMT:26554750,
	author = {Arturo, Martinez-Banaclocha Marcos},
	doi = {10.2174/0929867323666161129124549},
	title = {Cysteinet Dysregulation in Muscular Dystrophies: A Pathogenic Network Susceptible to Therapy},
	journal-iso = {CURR MED CHEM},
	journal = {CURRENT MEDICINAL CHEMISTRY},
	volume = {24},
	unique-id = {26554750},
	issn = {0929-8673},
	year = {2017},
	eissn = {1875-533X},
	pages = {312-330}
}

@article{MTMT:25773845,
	author = {Al-Samhari, Marwa M and Al-Rasheed, Nouf M and Al-Rejaie, Salim and Al-Rasheed, Nawal M and Hasan, Iman H and Mahmoud, Ayman M and Dzimiri, Nduna},
	doi = {10.1177/1535370215619707},
	title = {Possible involvement of the JAK/STAT signaling pathway in N-acetylcysteine-mediated antidepressant-like effects},
	journal-iso = {EXP BIOL MED},
	journal = {EXPERIMENTAL BIOLOGY AND MEDICINE},
	volume = {241},
	unique-id = {25773845},
	issn = {1535-3702},
	year = {2016},
	eissn = {1535-3699},
	pages = {509-518}
}

@article{MTMT:26206036,
	author = {Beard, Emma and Shahab, Lion and Cummings, Damian M and Michie, Susan and West, Robert},
	doi = {10.1007/s40263-016-0362-3},
	title = {New Pharmacological Agents to Aid Smoking Cessation and Tobacco Harm Reduction: What Has Been Investigated, and What Is in the Pipeline?},
	journal-iso = {CNS DRUGS},
	journal = {CNS DRUGS},
	volume = {30},
	unique-id = {26206036},
	issn = {1172-7047},
	year = {2016},
	pages = {951-983}
}

@article{MTMT:25773846,
	author = {Salum, Cristiane and Schmidt, Fanny and Michel, Patrick P and Del-Bel, Elaine and Raisman-Vozari, Rita},
	doi = {10.1007/s12640-015-9562-8},
	title = {Signaling Mechanisms in the Nitric Oxide Donor- and Amphetamine-Induced Dopamine Release in Mesencephalic Primary Cultured Neurons},
	journal-iso = {NEUROTOX RES},
	journal = {NEUROTOXICITY RESEARCH},
	volume = {29},
	unique-id = {25773846},
	issn = {1029-8428},
	year = {2016},
	eissn = {1476-3524},
	pages = {92-104},
	orcid-numbers = {Salum, Cristiane/0000-0003-0191-371X}
}

@article{MTMT:24453694,
	author = {Jahanshahi, B and Raoof, JB and Amiri-Aref, M and Ojani, R},
	doi = {10.1166/jnn.2015.10212},
	title = {A voltammetric sensor based on modified multi-walled carbon nanotubes for N-acetyl-L-cysteine determination in the presence of tryptophan using 4-chlorocatechol as a homogenous electrochemical catalyst},
	journal-iso = {J NANOSCI NANOTECHNO},
	journal = {JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY},
	volume = {15},
	unique-id = {24453694},
	issn = {1533-4880},
	year = {2015},
	eissn = {1533-4899},
	pages = {3429-3436}
}

@article{MTMT:24409033,
	author = {Taracha, E and Kaniuga, E and Chrapusta, S J and Boguszewski, P M and Lehner, M and Krzaścik, P and Płaźnik, A},
	doi = {10.1016/j.bbr.2014.12.005},
	title = {N-acetyl cysteine does not modify the sensitization of the rewarding effect of amphetamine as assessed with frequency-modulated 50-kHz vocalization in the rat},
	journal-iso = {BEHAV BRAIN RES},
	journal = {BEHAVIOURAL BRAIN RESEARCH},
	volume = {280},
	unique-id = {24409033},
	issn = {0166-4328},
	year = {2015},
	eissn = {1872-7549},
	pages = {141-148}
}

@article{MTMT:24409031,
	author = {Bavarsad, Shahripour R and Harrigan, M R and Alexandrov, A V},
	doi = {10.1002/brb3.208},
	title = {N-acetylcysteine (NAC) in neurological disorders: Mechanisms of action and therapeutic opportunities},
	journal-iso = {Brain and Behavior},
	journal = {Brain and Behavior},
	volume = {4},
	unique-id = {24409031},
	year = {2014},
	pages = {108-122}
}

@inbook{MTMT:24409133,
	author = {Giselli, Scaini and Gabriela, C Jeremias and Camila, B Furlanetto and Diogo, Dominguini and Clarissa, M Comim and João, Quevedo and Patrícia, F Schuck and Gustavo, C Ferreira and Emilio, L Streck},
	booktitle = {JIMD Reports - Case and Research Reports, Volume 13},
	doi = {10.1007/8904_2013_274},
	title = {Behavioral Responses in Rats Submitted to Chronic Administration of Branched-Chain Amino Acids},
	unique-id = {24409133},
	year = {2014},
	pages = {159-167}
}

@article{MTMT:23606782,
	author = {Berk, M and Malhi, GS and Gray, LJ and Dean, OM},
	doi = {10.1016/j.tips.2013.01.001},
	title = {The promise of N-acetylcysteine in neuropsychiatry},
	journal-iso = {TRENDS PHARMACOL SCI},
	journal = {TRENDS IN PHARMACOLOGICAL SCIENCES},
	volume = {34},
	unique-id = {23606782},
	issn = {0165-6147},
	year = {2013},
	pages = {167-177}
}

@article{MTMT:2285675,
	author = {Pásztiné Gere, Erzsébet and Jakus, Judit},
	doi = {10.1007/s12013-013-9608-6},
	title = {Protein phosphatases but not reactive oxygen species play functional role in acute amphetamine-mediated dopamine release},
	journal-iso = {CELL BIOCHEM BIOPHYS},
	journal = {CELL BIOCHEMISTRY AND BIOPHYSICS},
	volume = {66},
	unique-id = {2285675},
	issn = {1085-9195},
	year = {2013},
	eissn = {1559-0283},
	pages = {831-841}
}

@article{MTMT:23754943,
	author = {Farokhnia, M and Azarkolah, A and Adinehfar, F and Khodaie-Ardakani, MR and Hosseini, SMR and Yekehtaz, H and Tabrizi, M and Rezaei, F and Salehi, B and Sadeghi, SMH and Moghadam, M and Gharibi, F and Mirshafiee, O and Akhondzadeh, S},
	doi = {10.1097/WNF.0000000000000001},
	title = {N-Acetylcysteine as an Adjunct to Risperidone for Treatment of Negative Symptoms in Patients With Chronic Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study},
	journal-iso = {CLIN NEUROPHARMACOL},
	journal = {CLINICAL NEUROPHARMACOLOGY},
	volume = {36},
	unique-id = {23754943},
	issn = {0362-5664},
	year = {2013},
	pages = {185-192}
}

@article{MTMT:24489451,
	author = {Samuni, Y and Goldstein, S and Dean, OM and Berk, M},
	doi = {10.1016/j.bbagen.2013.04.016},
	title = {The chemistry and biological activities of N-acetylcysteine},
	journal-iso = {BBA-GEN SUBJECTS},
	journal = {BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS},
	volume = {1830},
	unique-id = {24489451},
	issn = {0304-4165},
	year = {2013},
	eissn = {1872-8006},
	pages = {4117-4129}
}

@article{MTMT:23689059,
	author = {Maes, M and Fišar, Z and Medina, M and Scapagnini, G and Nowak, G and Berk, M},
	doi = {10.1007/s10787-011-0111-7},
	title = {New drug targets in depression: Inflammatory, cell-mediate immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. and new drug candidates-Nrf2 activators and GSK-3 inhibitors},
	journal-iso = {INFLAMMOPHARMACOLOGY},
	journal = {INFLAMMOPHARMACOLOGY},
	volume = {20},
	unique-id = {23689059},
	issn = {0925-4692},
	year = {2012},
	eissn = {1568-5608},
	pages = {127-150}
}

@article{MTMT:22847161,
	author = {Smaga, I and Pomierny, B and Krzyzanowska, W and Pomierny-Chamiolo, L and Miszkiel, J and Niedzielska, E and Ogorka, A and Filip, M},
	doi = {10.1016/j.pnpbp.2012.06.018},
	title = {N-acetylcysteine possesses antidepressant-like activity through reduction of oxidative stress: Behavioral and biochemical analyses in rats},
	journal-iso = {PROG NEURO-PSYCHOPHARMACOL BIOL PSYCHIATR},
	journal = {PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY},
	volume = {39},
	unique-id = {22847161},
	issn = {0278-5846},
	year = {2012},
	eissn = {1878-4216},
	pages = {280-287}
}

@article{MTMT:21689441,
	author = {Olivia, Dean and Frank, Giorlando and Michael, Berk},
	doi = {10.1503/jpn.100057},
	title = {N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action},
	volume = {36},
	unique-id = {21689441},
	year = {2011},
	pages = {78-86}
}