TY - JOUR AU - Burch, Joseph S AU - Marcero, Jason R AU - Maschek, John Alan AU - Cox, James E AU - Jackson, Laurie K AU - Medlock, Amy E AU - Phillips, John D AU - Dailey, Harry A TI - Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis JF - BLOOD J2 - BLOOD VL - 132 PY - 2018 IS - 10 SP - 987 EP - 998 PG - 12 SN - 0006-4971 DO - 10.1182/blood-2018-01-829036 UR - https://m2.mtmt.hu/api/publication/27563081 ID - 27563081 LA - English DB - MTMT ER - TY - JOUR AU - Fernie, A.R. AU - Zhang, Y. AU - Sweetlove, L.J. TI - Passing the baton: Substrate channelling in respiratory metabolism JF - RESEARCH (LAMBERTVILLE, N.J.) J2 - RESEARCH VL - 2018 PY - 2018 SN - 2334-1009 DO - 10.1155/2018/1539325 UR - https://m2.mtmt.hu/api/publication/31340550 ID - 31340550 N1 - Cited By :4 Export Date: 10 June 2020 Correspondence Address: Sweetlove, L.J.; Department of Plant Sciences, University of Oxford, South Parks Road, United Kingdom; email: lee.sweetlove@plants.ox.ac.uk Funding details: 664620 Funding details: Horizon 2020 Framework Programme, H2020, 739582 Funding text 1: Alisdair R. Fernie and Youjun Zhang would like to thank the European Union’s Horizon 2020 Research and Innovation Programme, project PlantaSYST (SGA-CSA no. 739582 under FPA no. 664620) for supporting their research on the metabolon. Cited By :12 Export Date: 30 March 2021 Correspondence Address: Sweetlove, L.J.; Department of Plant Sciences, South Parks Road, United Kingdom; email: lee.sweetlove@plants.ox.ac.uk Funding details: Horizon 2020 Framework Programme, H2020, 739582 Funding details: Forecast Public Art, FPA, 664620 Funding text 1: Alisdair R. Fernie and Youjun Zhang would like to thank the European Union’s Horizon 2020 Research and Innovation Programme, project PlantaSYST (SGA-CSA no. 739582 under FPA no. 664620) for supporting their research on the metabolon. Funding text 2: Alisdair R. Fernie and Youjun Zhang would like to thank the European Union's Horizon 2020 Research and Innovation Programme, project PlantaSYST (SGA-CSA no. 739582 under FPA no. 664620) for supporting their research on the metabolon. AB - Despite species-specific differences in the pathways of respiratory metabolism are remarkably conserved across the kingdoms of life with glycolysis, the tricarboxylic acid cycle, and mitochondrial electron transport chain representing the major components of the process in the vast majority of organisms. In addition to being of critical importance in fueling life itself these pathways serve as interesting case studies for substrate channelling with research on this theme having been carried out for over 40 years. Here we provide a cross-kingdom review of the ample evidence for protein-protein interaction and enzyme assemblies within the three component pathways as well as describing the scarcer available evidence for substrate channelling itself. Copyright © 2018 Alisdair R. Fernie et al. LA - English DB - MTMT ER - TY - CHAP AU - Lonsdale, Derrick AU - Marrs, Chandler TI - Mitochondria, Thiamine, and Autonomic Dysfunction T2 - Thiamine deficiency disease, dysautonomia, and high calorie malnutrition PB - Elsevier Inc. CY - Amsterdam SN - 9780128103876 PY - 2017 SP - 59 EP - 103 PG - 45 DO - 10.1016/B978-0-12-810387-6.00003-4 UR - https://m2.mtmt.hu/api/publication/33616850 ID - 33616850 LA - English DB - MTMT ER - TY - JOUR AU - Zhang, Youjun AU - Beard, Katherine F M AU - Swart, Corne AU - Bergmann, Susan AU - Krahnert, Ina AU - Nikoloski, Zoran AU - Graf, Alexander AU - Ratcliffe, R George AU - Sweetlove, Lee J AU - Fernie, Alisdair R AU - Obata, Toshihiro TI - Protein-protein interactions and metabolite channelling in the plant tricarboxylic acid cycle JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 8 PY - 2017 PG - 11 SN - 2041-1723 DO - 10.1038/ncomms15212 UR - https://m2.mtmt.hu/api/publication/26764931 ID - 26764931 N1 - Funding Agency and Grant Number: EU FP7 Project ERA-NET Plant Genomics; STRESSNET; German Research Foundation (DFG); Max-Planck Society; German Academic Exchange Service (DAAD); International Max Planck Research Schools PhD programme (IMPRS); BBSRC CASE studentship with Advanced Technologies, Cambridge, UK Funding text: This work was supported by funding from EU FP7 Project ERA-NET Plant Genomics, STRESSNET (L.J.S., A.R.F., T.O.), German Research Foundation (DFG; T.O.), the Max-Planck Society (Z.N., A.G., A.R.F., T.O.), German Academic Exchange Service (DAAD; Y.Z.), International Max Planck Research Schools PhD programme (IMPRS; Y.Z.) and BBSRC CASE studentship with Advanced Technologies, Cambridge, UK (K.F.M.B.). We thank Dr Geert de Jaeger and Dr Jelle Van Leene (VIB, Belgium) for providing the PSB-D cell culture, Dr Naohiro Kato (Louisiana State University, LA) for providing the split- LUC vectors, Dr Peter Uetz (Karlsruhe Institute of Technology, Germany) for providing yeast-two-hybrid vectors, Juliane Neupert (MPIMP) and Dr Hardy Chan (Charite-Universitatsmedizin, Berlin, Germany) for their help in luminescence detector and Eugenia Maximova (MPIMP) for her help with the confocal microscopy. LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Gergely AU - Konrád, Csaba AU - Dóczi, Judit AU - Starkov, AA AU - Kawamata, H AU - Manfredi, G AU - Zhang, SF AU - Gibson, GE AU - Beal, MF AU - Ádám, Veronika AU - Chinopoulos, Christos TI - The negative impact of alpha-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation JF - FASEB JOURNAL J2 - FASEB J VL - 27 PY - 2013 IS - 6 SP - 2392 EP - 2406 PG - 15 SN - 0892-6638 DO - 10.1096/fj.12-220202 UR - https://m2.mtmt.hu/api/publication/2228167 ID - 2228167 AB - A decline in alpha-ketoglutarate dehydrogenase complex (KGDHC) activity has been associated with neurodegeneration. Provision of succinyl-CoA by KGDHC is essential for generation of matrix ATP (or GTP) by substrate-level phosphorylation catalyzed by succinyl-CoA ligase. Here, we demonstrate ATP consumption in respiration-impaired isolated and in situ neuronal somal mitochondria from transgenic mice with a deficiency of either dihydrolipoyl succinyltransferase (DLST) or dihydrolipoyl dehydrogenase (DLD) that exhibit a 20-48% decrease in KGDHC activity. Import of ATP into the mitochondrial matrix of transgenic mice was attributed to a shift in the reversal potential of the adenine nucleotide translocase toward more negative values due to diminished matrix substrate-level phosphorylation, which causes the translocase to reverse prematurely. Immunoreactivity of all three subunits of succinyl-CoA ligase and maximal enzymatic activity were unaffected in transgenic mice as compared to wild-type littermates. Therefore, decreased matrix substrate-level phosphorylation was due to diminished provision of succinyl-CoA. These results were corroborated further by the finding that mitochondria from wild-type mice respiring on substrates supporting substrate-level phosphorylation exhibited approximately 30% higher ADP-ATP exchange rates compared to those obtained from DLST+/- or DLD+/- littermates. We propose that KGDHC-associated pathologies are a consequence of the inability of respiration-impaired mitochondria to rely on "in-house" mitochondrial ATP reserves.-Kiss, G., Konrad, C., Doczi, J., Starkov, A. A., Kawamata, H., Manfredi, G., Zhang, S. F., Gibson, G. E., Beal, M. F., Adam-Vizi, V., Chinopoulos, C. The negative impact of alpha-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation. LA - English DB - MTMT ER - TY - JOUR AU - Michael, Gaster AU - Jan, O Nehlin AU - Ariane, D Minet TI - Impaired TCA cycle flux in mitochondria in skeletal muscle from type 2 diabetic subjects: Marker or maker of the diabetic phenotype? JF - ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY J2 - ARCH PHYSIOL BIOCHEM VL - 118 PY - 2012 IS - 3 SP - 156 EP - 189 PG - 34 SN - 1381-3455 DO - 10.3109/13813455.2012.656653 UR - https://m2.mtmt.hu/api/publication/22836618 ID - 22836618 N1 - Export Date: 20 April 2021 CODEN: APBIF Export Date: 22 April 2021 CODEN: APBIF LA - English DB - MTMT ER - TY - JOUR AU - Loro, E AU - Gianazza, E AU - Cazzola, S AU - Malena, A AU - Wait, R AU - Begum, S AU - Brizio, C AU - Dabbeni-Sala, F AU - Vergani, L TI - Development and characterization of polyspecific anti-mitochondrion antibodies for proteomics studies on in toto tissue homogenates JF - ELECTROPHORESIS J2 - ELECTROPHORESIS VL - 30 PY - 2009 IS - 8 SP - 1329 EP - 1341 PG - 13 SN - 0173-0835 DO - 10.1002/elps.200800576 UR - https://m2.mtmt.hu/api/publication/23450895 ID - 23450895 N1 - Megjegyzés-22218408 Z9: 2 DI: 10.1002/elps.200800576 LA - English DB - MTMT ER - TY - JOUR AU - Patil, AG AU - Ojha, MD AU - Bhandari, PA AU - Kulkarni, S TI - Protein folding dinamics study for protein-protein interactions VL - 1 PY - 2009 IS - 2 SP - 18 EP - 23 PG - 6 UR - https://m2.mtmt.hu/api/publication/22836933 ID - 22836933 LA - English DB - MTMT ER - TY - THES AU - Vajda, Szilvia TI - The role of Cyclophilin D and the adenine-nucleotide translocator in the impairment of mitochondrial functions PY - 2009 SP - 96 UR - https://m2.mtmt.hu/api/publication/22836898 ID - 22836898 LA - English DB - MTMT ER - TY - JOUR AU - Nakayama, S AU - Morita, T AU - Negishi, H AU - Ikegami, T AU - Sakaki, K AU - Kitamoto, D TI - Candida krusei produces ethanol without production of succinic acid; a potential advantage for ethanol recovery by pervaporation membrane separation. JF - FEMS YEAST RESEARCH J2 - FEMS YEAST RES VL - 8 PY - 2008 IS - 5 SP - 706 EP - 714 PG - 9 SN - 1567-1356 DO - 10.1111/j.1567-1364.2008.00384.x UR - https://m2.mtmt.hu/api/publication/21210496 ID - 21210496 LA - English DB - MTMT ER - TY - PAT AU - Francis, Joseph Carr AU - Graham, Carter AU - Anita, Anne Hamilton AU - Fiona, Suzanne Adair AU - Stephen, Williams TI - Methods for Protein Screening CY - Country:10017(13) PY - 2005 UR - https://m2.mtmt.hu/api/publication/22836833 ID - 22836833 LA - English DB - MTMT ER - TY - JOUR AU - DZIEWULSKA, SZWAJKOWSKA D AU - ZMOJDZIAN, M AU - DOBRYSZYCKI, P AU - KOCHMAN, M AU - DZUGAJ, A TI - The interaction of FBPase with aldolase: a kinetic and fluorescence investigation on chicken muscle enzymes JF - COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY J2 - COMP BIOCHEM PHYS B VL - 137 PY - 2004 IS - 1 SP - 115 EP - 129 PG - 15 SN - 1096-4959 DO - 10.1016/j.cbpc.2003.10.010 UR - https://m2.mtmt.hu/api/publication/10242169 ID - 10242169 N1 - Department of Animal Physiology, Zoological Institute, Wroclaw University, Cybulskiego 30, 50-205 Wroclaw, Poland Division of Biochemistry, Inst. Organ. Chem., Biochem. B., Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland Cited By :10 Export Date: 6 May 2021 CODEN: CBPBB Correspondence Address: Dzugaj, A.; Department of Animal Physiology, Cybulskiego 30, 50-205 Wroclaw, Poland; email: dzugajan@biol.uni.wroc.pl Chemicals/CAS: adenosine phosphate, 61-19-8, 8063-98-7; fructose 1,6 bisphosphate, 488-69-7; fructose bisphosphatase, 9001-52-9; fructose bisphosphate aldolase, 9024-52-6; magnesium ion, 22537-22-0 Funding text 1: This study was supported partially by the Wroclaw University of Technology and Wroclaw University. LA - English DB - MTMT ER - TY - THES AU - ROBERT, JASON QUINLAN TI - AN INVESTIGATION INTO THE ROLE OF PROTEIN-LIGAND INTERACTIONS ON OBLIGATE AND TRANSIENT PROTEIN-PROTEIN INTERACTIONS PY - 2004 SP - 240 UR - https://m2.mtmt.hu/api/publication/22836880 ID - 22836880 LA - English DB - MTMT ER - TY - JOUR AU - Ovádi, Judit AU - Srere, P.A. TI - Macromolecular Compartmentation and Channeling JF - INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY J2 - INT REV CYTOL VL - 192 PY - 1999 SP - 255 EP - 280 PG - 26 SN - 0074-7696 DO - 10.1016/s0074-7696(08)60529-x UR - https://m2.mtmt.hu/api/publication/32006096 ID - 32006096 N1 - Cited By :159 Export Date: 10 May 2021 CODEN: IRCYA Correspondence Address: Ovádi, J.; Institute of Enzymology, , Budapest, Hungary AB - One of the accepted characterizations of the living state is that it is complex to an extraordinary degree. Since our current understanding of the living condition is minimal and fragmentary, it is not surprising that our first descriptions are simplistic. However, in certain areas of metabolism, especially those that have been amenable to experimentation for the longest period of time, the simplistic explanations have been the most difficult to revise. For example, current texts of general biochemistry still view metabolism as occurring by a series of independent enzymes dispersed in a uniform aqueous environment. This notion has been shown to be deeply flawed by both experimental and theoretical considerations. Thus, there is ample evidence that, in many metabolic pathways, specific interactions between sequential enzymes occur as static and/or dynamic complexes. In addition, reversible interactions of enzymes with structural proteins and membranes is a common occurrence. The interactions of enzymes give rise to a higher level of complexity that must be accounted for when one wishes to understand the regulation of metabolism. One of the phenomena that occurs because of sequential enzyme interactions is the process of channeling. This article discusses enzyme interactions and channeling and summarizes experimental and theoretical results from a few well-studied examples. Copyright © 2000 by Academic Press. All rights of reproduction in any form reserved. LA - English DB - MTMT ER - TY - JOUR AU - Jayashree, Krishna SAINIS TI - Supramolecular Organization in Living Cells JF - PROCEEDINGS OF THE INDIAN NATIONAL SCIENCE ACADEMY J2 - PROC INDIAN NAT SCI ACAD PART A VL - B64 PY - 1998 IS - 3&4 SP - 197 EP - 212 PG - 16 SN - 0370-0046 UR - https://m2.mtmt.hu/api/publication/22882644 ID - 22882644 LA - English DB - MTMT ER - TY - JOUR AU - Johnson, J D AU - Mehus, J G AU - Tews, K AU - Milavetz, B I AU - Lambeth, D O TI - Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM VL - 273 PY - 1998 SP - 27580 EP - 27586 PG - 7 SN - 0021-9258 DO - 10.1074/jbc.273.42.27580 UR - https://m2.mtmt.hu/api/publication/20172627 ID - 20172627 LA - English DB - MTMT ER - TY - JOUR AU - Morgunov, I AU - Srere, PA TI - Interaction between citrate synthase and malate dehydrogenase - Substrate channeling of oxaloacetate JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM VL - 273 PY - 1998 IS - 45 SP - 29540 EP - 29544 PG - 5 SN - 0021-9258 DO - 10.1074/jbc.273.45.29540 UR - https://m2.mtmt.hu/api/publication/22803059 ID - 22803059 LA - English DB - MTMT ER - TY - JOUR AU - Sonawat, I AU - Sonawat, H M TI - Channeling of TCA cycle intermediates in Saccharomyces cerevisiae JF - INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS J2 - INDIAN J BIOCHEM BIOPHYS VL - 35 PY - 1998 SP - 260 EP - 265 PG - 6 SN - 0301-1208 UR - https://m2.mtmt.hu/api/publication/20174278 ID - 20174278 LA - English DB - MTMT ER - TY - JOUR AU - Gadde, DM AU - McCammon, MT TI - Mutations in the IDH2 gene encoding the catalytic subunit of the yeast NAD(+)-dependent isocitrate dehydrogenase can be suppressed by mutations in the CIT1 gene encoding citrate synthase and other genes of oxidative metabolism JF - ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS J2 - ARCH BIOCHEM BIOPHYS VL - 344 PY - 1997 IS - 1 SP - 139 EP - 149 PG - 11 SN - 0003-9861 DO - 10.1006/abbi.1997.0191 UR - https://m2.mtmt.hu/api/publication/23314257 ID - 23314257 LA - English DB - MTMT ER - TY - JOUR AU - Maehashi, K AU - Yamamoto, Y AU - Higashi, K AU - Yoshii, H TI - Effects of acetic acid on respiration of Debaryomyces hansenii: (Studies on the mechanism of the antifungal action of acetic acid, part III) JF - NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI / JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY J2 - J JPN SOC FOOD SCI VL - 43 PY - 1996 IS - 3 SP - 225 EP - 230 PG - 6 SN - 1341-027X UR - https://m2.mtmt.hu/api/publication/23233028 ID - 23233028 LA - Japanese DB - MTMT ER - TY - JOUR AU - Mitchell, CG TI - Identification of a multienzyme complex of the tricarboxylic acid cycle enzymes containing citrate synthase isoenzymes from Pseudomonas aeruginosa JF - BIOCHEMICAL JOURNAL J2 - BIOCHEM J VL - 313 PY - 1996 SP - 769 EP - 774 PG - 6 SN - 0264-6021 DO - 10.1042/bj3130769 UR - https://m2.mtmt.hu/api/publication/23314184 ID - 23314184 N1 - PN 3 LA - English DB - MTMT ER - TY - JOUR AU - PHIZICKY, EM AU - FIELDS, S TI - PROTEIN-PROTEIN INTERACTIONS - METHODS FOR DETECTION AND ANALYSIS JF - MICROBIOLOGICAL REVIEWS J2 - MICROBIOL REV VL - 59 PY - 1995 IS - 1 SP - 94 EP - 123 PG - 30 SN - 0146-0749 DO - 10.1128/MMBR.59.1.94-123.1995 UR - https://m2.mtmt.hu/api/publication/21207460 ID - 21207460 N1 - Funding Agency and Grant Number: NCI NIH HHS [CA 28146] Funding Source: Medline; NIGMS NIH HHS [GM 49065] Funding Source: Medline; NATIONAL CANCER INSTITUTE [P01CA028146] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM049065] Funding Source: NIH RePORTER LA - English DB - MTMT ER - TY - JOUR AU - Small, W C AU - Brodeur, R D AU - Sandor, A AU - Fedorova, N AU - LI, G Y AU - Butow, R A AU - Srere, P A TI - ENZYMATIC AND METABOLIC STUDIES ON RETROGRADE REGULATION MUTANTS OF YEAST JF - BIOCHEMISTRY J2 - BIOCHEMISTRY-US VL - 34 PY - 1995 SP - 5569 EP - 5576 PG - 8 SN - 0006-2960 DO - 10.1021/bi00016a031 UR - https://m2.mtmt.hu/api/publication/20172764 ID - 20172764 N1 - Funding Agency and Grant Number: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R37GM022525, R01GM022525] Funding Source: NIH RePORTER; NIGMS NIH HHS [GM22525] Funding Source: Medline LA - English DB - MTMT ER - TY - JOUR AU - SRERE, PA TI - 17TH LIPMANN,FRITZ LECTURE - WANDERINGS (WONDERINGS) IN METABOLISM JF - BIOLOGICAL CHEMISTRY HOPPE-SEYLER J2 - BIOL CHEM H-S VL - 374 PY - 1993 IS - 9 SP - 833 EP - 842 PG - 10 SN - 0177-3593 DO - 10.1515/bchm3.1993.374.7-12.833 UR - https://m2.mtmt.hu/api/publication/23314266 ID - 23314266 N1 - Funding Agency and Grant Number: NIDDK NIH HHS [DK 11313] Funding Source: Medline; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK011313] Funding Source: NIH RePORTER LA - English DB - MTMT ER - TY - JOUR AU - Sümegi, Balázs AU - Sherry, A D AU - Malloy, C R AU - Srere, P A TI - EVIDENCE FOR ORIENTATION-CONSERVED TRANSFER IN THE TCA CYCLE IN SACCHAROMYCES-CEREVISIAE - C-13 NMR-STUDIES JF - BIOCHEMISTRY J2 - BIOCHEMISTRY-US VL - 32 PY - 1993 SP - 12725 EP - 12729 PG - 5 SN - 0006-2960 DO - 10.1021/bi00210a022 UR - https://m2.mtmt.hu/api/publication/1060962 ID - 1060962 N1 - Export Date: 27 January 2024 LA - English DB - MTMT ER - TY - JOUR AU - FAHIEN, LA AU - TELLER, JK TI - GLUTAMATE-MALATE METABOLISM IN LIVER-MITOCHONDRIA - A MODEL CONSTRUCTED ON THE BASIS OF MITOCHONDRIAL LEVELS OF ENZYMES, SPECIFICITY, DISSOCIATION-CONSTANTS, AND STOICHIOMETRY OF HETERO-ENZYME COMPLEXES JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM VL - 267 PY - 1992 IS - 15 SP - 10411 EP - 10422 PG - 12 SN - 0021-9258 UR - https://m2.mtmt.hu/api/publication/23307238 ID - 23307238 N1 - Funding Agency and Grant Number: NATIONAL CANCER INSTITUTE [R01CA040445] Funding Source: NIH RePORTER; NCI NIH HHS [CA 40445] Funding Source: Medline LA - English DB - MTMT ER - TY - JOUR AU - Salvucci, M E TI - SUBUNIT INTERACTIONS OF RUBISCO ACTIVASE - POLYETHYLENE-GLYCOL PROMOTES SELF-ASSOCIATION, STIMULATES ATPASE AND ACTIVATION ACTIVITIES, AND ENHANCES INTERACTIONS WITH RUBISCO JF - ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS J2 - ARCH BIOCHEM BIOPHYS VL - 298 PY - 1992 SP - 688 EP - 696 PG - 9 SN - 0003-9861 DO - 10.1016/0003-9861(92)90467-B UR - https://m2.mtmt.hu/api/publication/20172636 ID - 20172636 LA - English DB - MTMT ER - TY - JOUR AU - Sümegi, Balázs AU - Porpáczy, Zoltán AU - Mc, Cammon M T AU - Sherry, A D AU - Malloy, C R AU - Srere, PA TI - Regulatory Consequences of Organization of Citric Acid Cycle Enzymes JF - CURRENT TOPICS IN CELLULAR REGULATION J2 - CURR TOP CELL REGUL VL - 33 PY - 1992 SP - 249 EP - 260 PG - 12 SN - 0070-2137 DO - 10.1016/B978-0-12-152833-1.50019-8 UR - https://m2.mtmt.hu/api/publication/1061520 ID - 1061520 LA - English DB - MTMT ER - TY - JOUR AU - Aragon, J J AU - Sols, A TI - REGULATION OF ENZYME-ACTIVITY IN THE CELL - EFFECT OF ENZYME CONCENTRATION JF - FASEB JOURNAL J2 - FASEB J VL - 5 PY - 1991 SP - 2945 EP - 2950 PG - 6 SN - 0892-6638 DO - 10.1096/fasebj.5.14.1752361 UR - https://m2.mtmt.hu/api/publication/20172709 ID - 20172709 LA - English DB - MTMT ER - TY - JOUR AU - Sümegi, Balázs AU - Porpáczy, Zoltán AU - Alkonyi, István TI - Kinetic advantage of the interaction between the fatty acid β-oxidation enzymes and the complexes of the respiratory chain JF - BIOCHIMICA ET BIOPHYSICA ACTA J2 - BIOCHIM BIOPHYS ACTA VL - 1081 PY - 1991 IS - 2 SP - 121 EP - 128 PG - 8 SN - 0006-3002 DO - 10.1016/0005-2760(91)90016-B UR - https://m2.mtmt.hu/api/publication/1060971 ID - 1060971 N1 - Export Date: 27 January 2024; CODEN: BBLLA LA - English DB - MTMT ER - TY - JOUR AU - Albe, K R AU - Butler, M H AU - Wright, B E TI - CELLULAR CONCENTRATIONS OF ENZYMES AND THEIR SUBSTRATES JF - JOURNAL OF THEORETICAL BIOLOGY J2 - J THEOR BIOL VL - 143 PY - 1990 SP - 163 EP - 195 PG - 33 SN - 0022-5193 DO - 10.1016/S0022-5193(05)80266-8 UR - https://m2.mtmt.hu/api/publication/20173123 ID - 20173123 N1 - Funding Agency and Grant Number: NATIONAL INSTITUTE ON AGING [R01AG003884] Funding Source: NIH RePORTER; NIA NIH HHS [AG03884] Funding Source: Medline LA - English DB - MTMT ER - TY - JOUR AU - Sümegi, Balázs AU - Sherry, A D AU - Malloy, C R TI - CHANNELING OF TCA CYCLE INTERMEDIATES IN CULTURED SACCHAROMYCES-CEREVISIAE JF - BIOCHEMISTRY J2 - BIOCHEMISTRY-US VL - 29 PY - 1990 SP - 9106 EP - 9110 PG - 5 SN - 0006-2960 DO - 10.1021/bi00491a002 UR - https://m2.mtmt.hu/api/publication/1060973 ID - 1060973 N1 - Export Date: 27 January 2024 LA - English DB - MTMT ER - TY - JOUR AU - BEECKMANS, S AU - VANDRIESSCHE, E AU - KANAREK, L TI - THE VISUALIZATION BY AFFINITY ELECTROPHORESIS OF A SPECIFIC ASSOCIATION BETWEEN THE CONSECUTIVE CITRIC-ACID CYCLE ENZYMES FUMARASE AND MALATE-DEHYDROGENASE JF - EUROPEAN JOURNAL OF BIOCHEMISTRY J2 - EUR J BIOCHEM VL - 183 PY - 1989 IS - 2 SP - 449 EP - 454 PG - 6 SN - 0014-2956 DO - 10.1111/j.1432-1033.1989.tb14948.x UR - https://m2.mtmt.hu/api/publication/21502145 ID - 21502145 LA - English DB - MTMT ER - TY - JOUR AU - Fahien, L A AU - Macdonald, M J AU - Teller, J K AU - Fibich, B AU - Fahien, C M TI - KINETIC ADVANTAGES OF HETERO-ENZYME COMPLEXES WITH GLUTAMATE-DEHYDROGENASE AND THE ALPHA-KETOGLUTARATE DEHYDROGENASE COMPLEX JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM VL - 264 PY - 1989 SP - 12303 EP - 12312 PG - 10 SN - 0021-9258 UR - https://m2.mtmt.hu/api/publication/20173082 ID - 20173082 LA - English DB - MTMT ER - TY - JOUR AU - KELETI, T AU - Ovádi, Judit AU - BATKE, J TI - Kinetic and physico-chemical analysis of enzyme complexes and their possible role in the control of metabolism. JF - PROGRESS IN BIOPHYSICS AND MOLECULAR BIOLOGY J2 - PROG BIOPHYS MOL BIO VL - 53 PY - 1989 SP - 105 EP - 152 PG - 48 SN - 0079-6107 DO - 10.1016/0079-6107(89)90016-3 UR - https://m2.mtmt.hu/api/publication/1012907 ID - 1012907 LA - English DB - MTMT ER - TY - JOUR AU - Lyubarev, A E AU - Kurganov, B I TI - SUPRAMOLECULAR ORGANIZATION OF TRICARBOXYLIC-ACID CYCLE ENZYMES JF - BIOSYSTEMS J2 - BIOSYSTEMS VL - 22 PY - 1989 SP - 91 EP - 102 PG - 12 SN - 0303-2647 DO - 10.1016/0303-2647(89)90038-5 UR - https://m2.mtmt.hu/api/publication/20172717 ID - 20172717 LA - English DB - MTMT ER - TY - JOUR AU - Boquist, L AU - Boquist, S AU - Ericsson, I TI - STRUCTURAL BETA-CELL CHANGES AND TRANSIENT HYPERGLYCEMIA IN MICE TREATED WITH COMPOUNDS INDUCING INHIBITED CITRIC-ACID CYCLE ENZYME-ACTIVITY JF - DIABETES J2 - DIABETES VL - 37 PY - 1988 SP - 89 EP - 98 PG - 10 SN - 0012-1797 DO - 10.2337/diabetes.37.1.89 UR - https://m2.mtmt.hu/api/publication/20172653 ID - 20172653 LA - English DB - MTMT ER - TY - JOUR AU - Fahien, LA AU - Kmiotek, EH AU - Macdonald, MJ AU - Fibich, B AU - Mandic, M TI - Regulation of Malate-dehydrogenase Activity by Glutamate, Citrate, Alpha-ketoglutarate, And Multienzyme Interaction JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM VL - 263 PY - 1988 IS - 22 SP - 10687 EP - 10697 PG - 11 SN - 0021-9258 UR - https://m2.mtmt.hu/api/publication/22803064 ID - 22803064 N1 - Funding Agency and Grant Number: NCI NIH HHS [CA40445] Funding Source: Medline; NIADDK NIH HHS [AM28348] Funding Source: Medline; NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE &KIDNEY DISEASES [R01AM028348] Funding Source: NIH RePORTER; NATIONAL CANCER INSTITUTE [R01CA040445] Funding Source: NIH RePORTER LA - English DB - MTMT ER - TY - JOUR AU - Forster, M E C TI - CITRIC-ACID CYCLE AS A ONE-STEP REACTION JF - JOURNAL OF THEORETICAL BIOLOGY J2 - J THEOR BIOL VL - 133 PY - 1988 SP - 1 EP - 11 PG - 11 SN - 0022-5193 DO - 10.1016/S0022-5193(88)80020-1 UR - https://m2.mtmt.hu/api/publication/20172723 ID - 20172723 LA - English DB - MTMT ER - TY - JOUR AU - Keleti, T. AU - Ovádi, Judit TI - Control of Metabolism by Dynamic Macromolecular Interactions JF - CURRENT TOPICS IN CELLULAR REGULATION J2 - CURR TOP CELL REGUL VL - 29 PY - 1988 IS - C SP - 1 EP - 33 PG - 33 SN - 0070-2137 DO - 10.1016/B978-0-12-152829-4.50003-3 UR - https://m2.mtmt.hu/api/publication/32006019 ID - 32006019 N1 - Cited By :41 Export Date: 10 May 2021 Chemicals/CAS: Macromolecular Substances; Multienzyme Complexes AB - This chapter discusses the control of metabolism by dynamic macromolecular interactions. Metabolic pathways are controlled and directed by pacemaker, bottleneck, and key enzymes. In general, no single enzyme is responsible for the control of a whole metabolic pathway. In pursuing the pacemaker theory, attempts are made to quantify metabolic regulation, and one studies each enzyme in a sequence separately in situ, determines its kinetic properties in the greatest possible detail and accuracy, and then seeks to determine how it works when it is in the intact cell. In prokaryotes and in eukaryotes the largest macrocompartment is the cytoplasm, containing quantities of soluble enzymes and is full of membranes associated with a great variety of organelles. A theoretical analysis of glycolysis in human erythrocytes has been provided, implicitly assuming that it proceeds in a homogeneous bulk solution without any interaction among the participating enzymes. © 1988 ACADEMIC PRESS, INC. LA - English DB - MTMT ER - TY - JOUR AU - Walsh, J L AU - Knull, H R TI - HETEROMEROUS INTERACTIONS AMONG GLYCOLYTIC-ENZYMES AND OF GLYCOLYTIC-ENZYMES WITH F-ACTIN - EFFECTS OF POLY(ETHYLENE GLYCOL) JF - BIOCHIMICA ET BIOPHYSICA ACTA J2 - BIOCHIM BIOPHYS ACTA VL - 952 PY - 1988 SP - 83 EP - 91 PG - 9 SN - 0006-3002 DO - 10.1016/0167-4838(88)90104-5 UR - https://m2.mtmt.hu/api/publication/20172724 ID - 20172724 N1 - Funding Agency and Grant Number: NINDS NIH HHS [NS-17711] Funding Source: Medline; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS017711] Funding Source: NIH RePORTER LA - English DB - MTMT ER - TY - JOUR AU - BEECKMANS, S AU - KANAREK, L TI - ENZYME ENZYME INTERACTIONS AS MODULATORS OF THE METABOLIC FLUX THROUGH THE CITRIC-ACID CYCLE JF - BIOCHEMICAL SOCIETY SYMPOSIUM J2 - BIOCHEM SOC SYMP VL - 1987 PY - 1987 IS - 54 SP - 163 EP - 172 PG - 10 SN - 0067-8694 UR - https://m2.mtmt.hu/api/publication/23233025 ID - 23233025 LA - English DB - MTMT ER - TY - JOUR AU - BRIDGER, WA AU - WOLODKO, WT AU - HENNING, W AU - UPTON, C AU - MAJUMDAR, R AU - WILLIAMS, SP TI - THE SUBUNITS OF SUCCINYL-COENZYME-A SYNTHETASE - FUNCTION AND ASSEMBLY JF - BIOCHEMICAL SOCIETY SYMPOSIUM J2 - BIOCHEM SOC SYMP VL - 1987 PY - 1987 IS - 54 SP - 103 EP - 111 PG - 9 SN - 0067-8694 UR - https://m2.mtmt.hu/api/publication/23233023 ID - 23233023 LA - English DB - MTMT ER - TY - JOUR AU - Lyubarev, A E AU - Kurganov, B I TI - SUPRAMOLECULAR ORGANIZATION OF ENZYMES OF THE TRICARBOXYLIC-ACID CYCLE JF - MOLECULAR BIOLOGY J2 - MOL BIOL VL - 21 PY - 1987 SP - 1062 EP - 1072 PG - 11 SN - 0026-8933 UR - https://m2.mtmt.hu/api/publication/20172721 ID - 20172721 N1 - Part number: 1 LA - English DB - MTMT ER - TY - JOUR AU - Porpáczy, Zoltán AU - Sümegi, Balázs AU - Alkonyi, István TI - Interaction between NAD-dependent isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase complex, and NADH:ubiquinone oxidoreductase JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM VL - 262 PY - 1987 IS - 20 SP - 9509 EP - 9514 PG - 6 SN - 0021-9258 UR - https://m2.mtmt.hu/api/publication/1060978 ID - 1060978 N1 - Export Date: 27 January 2024 LA - English DB - MTMT ER - TY - JOUR AU - Srere, P A AU - Sümegi, Balázs AU - Sherry, A D TI - ORGANIZATIONAL ASPECTS OF THE CITRIC-ACID CYCLE JF - BIOCHEMICAL SOCIETY SYMPOSIUM J2 - BIOCHEM SOC SYMP VL - 1987 PY - 1987 IS - 54 SP - 173 EP - 181 PG - 9 SN - 0067-8694 UR - https://m2.mtmt.hu/api/publication/1060975 ID - 1060975 N1 - Export Date: 27 January 2024 LA - English DB - MTMT ER - TY - JOUR AU - SRERE, PA TI - COMPLEXES OF SEQUENTIAL METABOLIC ENZYMES JF - ANNUAL REVIEW OF BIOCHEMISTRY J2 - ANNU REV BIOCHEM VL - 56 PY - 1987 SP - 89 EP - 124 PG - 36 SN - 0066-4154 DO - 10.1146/annurev.bi.56.070187.000513 UR - https://m2.mtmt.hu/api/publication/30795153 ID - 30795153 N1 - Export Date: 12 October 2021 LA - English DB - MTMT ER - TY - JOUR AU - Srivastava, D K AU - Bernhard, S A TI - BIOPHYSICAL CHEMISTRY OF METABOLIC REACTION SEQUENCES IN CONCENTRATED ENZYME SOLUTION AND IN THE CELL JF - ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING J2 - ANNU REV BIOPHYS BIOENG VL - 16 PY - 1987 SP - 175 EP - 204 PG - 30 SN - 0084-6589 DO - 10.1146/annurev.biophys.16.1.175 UR - https://m2.mtmt.hu/api/publication/20172728 ID - 20172728 LA - English DB - MTMT ER - TY - JOUR AU - Sümegi, Balázs AU - Liposits, Zsolt AU - Inman, L AU - Paull, W K AU - Srere, P A TI - Electronmicroscopic study on the size of pyruvate dehydrogenase complex in situ JF - EUROPEAN JOURNAL OF BIOCHEMISTRY J2 - EUR J BIOCHEM VL - 169 PY - 1987 SP - 223 EP - 230 PG - 8 SN - 0014-2956 DO - 10.1111/j.1432-1033.1987.tb13601.x UR - https://m2.mtmt.hu/api/publication/1060977 ID - 1060977 N1 - Export Date: 27 January 2024 LA - English DB - MTMT ER - TY - JOUR AU - Barnes, S J AU - Weitzman, P D J TI - ORGANIZATION OF CITRIC-ACID CYCLE ENZYMES INTO A MULTIENZYME CLUSTER JF - FEBS LETTERS J2 - FEBS LETT VL - 201 PY - 1986 SP - 267 EP - 270 PG - 4 SN - 0014-5793 DO - 10.1016/0014-5793(86)80621-4 UR - https://m2.mtmt.hu/api/publication/20172730 ID - 20172730 LA - English DB - MTMT ER - TY - JOUR AU - Kispál, Gyula AU - Sümegi, Balázs AU - Alkonyi, István TI - ISOLATION AND CHARACTERIZATION OF 3-HYDROXYACYL COENZYME-A DEHYDROGENASE-BINDING PROTEIN FROM PIG-HEART INNER MITOCHONDRIAL-MEMBRANE JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM VL - 261 PY - 1986 IS - 30 SP - 14209 EP - 14213 PG - 5 SN - 0021-9258 UR - https://m2.mtmt.hu/api/publication/1060980 ID - 1060980 N1 - Export Date: 27 January 2024; CODEN: JBCHA LA - English DB - MTMT ER - TY - JOUR AU - Nishimura, J S TI - SUCCINYL-COA SYNTHETASE STRUCTURE-FUNCTION-RELATIONSHIPS AND OTHER CONSIDERATIONS JF - ADVANCES IN ENZYMOLOGY AND RELATED AREAS OF MOLECULAR BIOLOGY J2 - ADV ENZYMOL RAMB VL - 58 PY - 1986 SP - 141 EP - 172 PG - 32 SN - 0065-258X UR - https://m2.mtmt.hu/api/publication/20173009 ID - 20173009 LA - English DB - MTMT ER - TY - CHAP AU - Srere, P A AU - Sümegi, Balázs ED - Srere, P A TI - Organization of the Mitochondrial Matrix T2 - Miocardial and Skeletar Muscle Bio-energetics PB - Plenum Press CY - New York, New York T3 - Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 194. PY - 1986 SP - 13 EP - 25 PG - 13 UR - https://m2.mtmt.hu/api/publication/1061506 ID - 1061506 LA - English DB - MTMT ER - TY - JOUR AU - Srivastava, DK AU - Bernhard, SA TI - Enzyme Enzyme Interactions and the Regulation of Metabolic Reaction Pathways. JF - CURRENT TOPICS IN CELLULAR REGULATION J2 - CURR TOP CELL REGUL VL - 28 PY - 1986 SP - 1 EP - 68 PG - 68 SN - 0070-2137 DO - 10.1016/B978-0-12-152828-7.50003-2 UR - https://m2.mtmt.hu/api/publication/22058588 ID - 22058588 LA - English DB - MTMT ER - TY - JOUR AU - Buck, D AU - Spencer, M E AU - Guest, J R TI - PRIMARY STRUCTURE OF THE SUCCINYL-COA SYNTHETASE OF ESCHERICHIA-COLI JF - BIOCHEMISTRY J2 - BIOCHEMISTRY-US VL - 24 PY - 1985 SP - 6245 EP - 6252 PG - 8 SN - 0006-2960 DO - 10.1021/bi00343a031 UR - https://m2.mtmt.hu/api/publication/20172663 ID - 20172663 LA - English DB - MTMT ER - TY - JOUR AU - Datta, A AU - Merz, J M AU - Spivey, H O TI - SUBSTRATE CHANNELING OF OXALACETATE IN SOLID-STATE COMPLEXES OF MALATE-DEHYDROGENASE AND CITRATE SYNTHASE JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM VL - 260 PY - 1985 SP - 5008 EP - 5012 PG - 5 SN - 0021-9258 UR - https://m2.mtmt.hu/api/publication/20172731 ID - 20172731 LA - English DB - MTMT ER - TY - JOUR AU - Pamela, J Camp AU - Douglas, D Randall TI - Purification and Characterization of the Pea Chloroplast Pyruvate Dehydrogenase Complex 1. A Source of Acetyl-CoA and NADH for Fatty Acid Biosynthesis TS - A Source of Acetyl-CoA and NADH for Fatty Acid Biosynthesis JF - PLANT PHYSIOLOGY J2 - PLANT PHYSIOL VL - 77 PY - 1985 SP - 571 EP - 577 PG - 7 SN - 0032-0889 DO - 10.1104/pp.77.3.571 UR - https://m2.mtmt.hu/api/publication/22836694 ID - 22836694 LA - English DB - MTMT ER - TY - JOUR AU - Robinson, J B AU - Srere, P A TI - ORGANIZATION OF KREBS TRICARBOXYLIC-ACID CYCLE ENZYMES IN MITOCHONDRIA JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM VL - 260 PY - 1985 SP - 800 EP - 805 PG - 6 SN - 0021-9258 UR - https://m2.mtmt.hu/api/publication/20172664 ID - 20172664 LA - English DB - MTMT ER - TY - JOUR AU - Sümegi, Balázs AU - Gilbert, H F AU - Srere, P A TI - INTERACTION BETWEEN CITRATE SYNTHASE AND THIOLASE JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM VL - 260 PY - 1985 SP - 188 EP - 190 PG - 3 SN - 0021-9258 UR - https://m2.mtmt.hu/api/publication/1060983 ID - 1060983 N1 - Export Date: 27 January 2024; CODEN: JBCHA LA - English DB - MTMT ER - TY - JOUR AU - Srere, P A TI - WHY ARE ENZYMES SO BIG JF - TRENDS IN BIOCHEMICAL SCIENCES J2 - TRENDS BIOCHEM SCI VL - 9 PY - 1984 SP - 387 EP - 390 PG - 4 SN - 0968-0004 DO - 10.1016/0968-0004(84)90221-4 UR - https://m2.mtmt.hu/api/publication/20172667 ID - 20172667 LA - English DB - MTMT ER - TY - JOUR AU - Sümegi, Balázs AU - Srere, P A TI - BINDING OF THE ENZYMES OF FATTY-ACID BETA-OXIDATION AND SOME RELATED ENZYMES TO PIG-HEART INNER MITOCHONDRIAL-MEMBRANE JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM VL - 259 PY - 1984 SP - 8748 EP - 8752 PG - 5 SN - 0021-9258 UR - https://m2.mtmt.hu/api/publication/1060986 ID - 1060986 N1 - Export Date: 27 January 2024; CODEN: JBCHA LA - English DB - MTMT ER - TY - JOUR AU - Sümegi, Balázs AU - Srere, P A TI - Complex I Binds Several Mitochondrial NAD-coupled Dehydrogenases JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM VL - 259 PY - 1984 IS - 24 SP - 15040 EP - 15045 PG - 6 SN - 0021-9258 UR - https://m2.mtmt.hu/api/publication/1060984 ID - 1060984 N1 - Export Date: 27 January 2024; CODEN: JBCHA LA - English DB - MTMT ER - TY - JOUR AU - Sümegi, Balázs AU - Alkonyi, István TI - A STUDY ON THE PHYSICAL INTERACTION BETWEEN THE PYRUVATE-DEHYDROGENASE COMPLEX AND CITRATE SYNTHASE JF - BIOCHIMICA ET BIOPHYSICA ACTA J2 - BIOCHIM BIOPHYS ACTA VL - 749 PY - 1983 SP - 163 EP - 171 PG - 9 SN - 0006-3002 DO - 10.1016/0167-4838(83)90248-0 UR - https://m2.mtmt.hu/api/publication/1060988 ID - 1060988 N1 - Export Date: 27 January 2024; CODEN: BBAED LA - English DB - MTMT ER -