@article{MTMT:3421457,
	title = {Diabetes mellitus: endotheldiszfunkció és haemostasiselváltozások [Diabetes mellitus: endothelial dysfunction and changes in hemostasis]},
	url = {https://m2.mtmt.hu/api/publication/3421457},
	author = {Babik, Barna and Peták, Ferenc and Agócs, Szilvia and Blaskovics, I and Alacs, E and Bodo, K and Südy, Roberta},
	doi = {10.1556/650.2018.31130},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {159},
	unique-id = {3421457},
	issn = {0030-6002},
	abstract = {Diabetes mellitus involves a group of chronic metabolic 
		disorders with elevated blood glucose concentrations. Since 
		this disease needs lifelong treatment and care, the medical 
		and social aspects present major public health concerns and 
		pose a global challenge for health care providers. The number 
		of aged patients with degenerative diseases undergoing 
		surgical procedures is continuously increasing, resulting in 
		an overwhelming dominance of diabetes in the perioperative 
		care. There is a particular need for an increased awareness of 
		diabetic patients in cardiovascular units, where the incidence 
		of this disease reaches as high as 30-40%. The main hallmarks 
		of the pathologic metabolic milieu of diabetes are 
		hyperglycaemia, insulin resistance and pathologic lipid 
		metabolism. The biochemical, cellular and organ-level 
		pathophysiological changes lead to endothelial dysfunction 
		including a low-grade prothrombotic balance, inflammatory 
		state and, as a consequence, impaired micro- and 
		macrocirculation. Diabetes is also followed by platelet 
		dysfunction resulting from intracellular hyperglycaemia, 
		because thrombocytes have insulin-independent glucose 
		transporters in their cell membrane. The levels of the 
		coagulation factors of the plasma are increased, and these 
		factors are also modified by oxidation and glycation. Diabetes 
		mellitus is a prothrombotic condition resulting from direct 
		and indirect tendencies of the endothelial platelet and the 
		plasma coagulation factors. The basic "bench to clinical 
		basics" knowledge of the endothelial dysfunction and 
		prothrombotic balance in diabetes may contribute to the better 
		understanding of the clinical focuses in the perioperative 
		care of patients with diabetes mellitus. Orv Hetil. 2018; 
		159(33): 1335-1345.},
	year = {2018},
	eissn = {1788-6120},
	pages = {1335-1345},
	orcid-numbers = {Babik, Barna/0000-0003-3739-8879; Peták, Ferenc/0000-0001-6249-9327}
}

@article{MTMT:23137513,
	title = {Endothelial dysfunction in development of cerebrovascular disorders in patients with diabetes mellitus},
	url = {https://m2.mtmt.hu/api/publication/23137513},
	author = {Kosobyan, EP and Yarek-Martynova, IR and Yasamanova, AN and Kolesnikova, TI and Martynov, MJ},
	doi = {10.14341/2072-0351-5978},
	journal-iso = {DIAB MELLIT},
	journal = {DIABETES MELLITUS},
	volume = {15},
	unique-id = {23137513},
	issn = {2072-0351},
	abstract = {В возникновении цереброваскулярного поражения у пациентов с сахарным диабетом важнейшую роль играют эндо- телиальная дисфункция и нарушение гемостаза в сосудах головного мозга. На развитие и прогрессирование нарушения микроциркуляции, ишемизации ткани головного мозга оказывают влияние такие факторы, как гипер- и гипогликемия, гиперинсулинемия, инсулинорезистентность, избыточный вес. Для неинвазивной оценки гемодинамических изменений успешно используется транскраниальная допплерография.Endothelial dysfunction and aberrations of haemostasis play an important part in development of cerebrovascular disorders in patients with diabetes mellitus. Such factors as hyper- and hypoglycemia, hyperinsulinism, insulin resistance and excessive weight affect progression of microcirculation deficiency and cerebral ischemia. Transcranial Doppler ultrasound examination is useful as a noninvasive method of hemodynamic assessment.},
	keywords = {diabetes mellitus; endothelial dysfunction; сахарный диабет; эндотелиальная дисфункция; церебральная ангиопатия; Cerebral angiopathy},
	year = {2012},
	eissn = {2072-0378},
	pages = {42-48}
}

@article{MTMT:20775065,
	title = {Dynamic cerebral autoregulatory capacity is affected early in Type 2 diabetes},
	url = {https://m2.mtmt.hu/api/publication/20775065},
	author = {Kim, Y -S and Immink, R V and Stok, W J and Karemaker, J M and Secher, N H and Van, Lieshourt J J},
	doi = {10.1042/CS20070458},
	journal-iso = {CLIN SCI},
	journal = {CLINICAL SCIENCE},
	volume = {115},
	unique-id = {20775065},
	issn = {0143-5221},
	year = {2008},
	eissn = {1470-8736},
	pages = {255-262}
}

@article{MTMT:20145683,
	title = {Impairment of cerebral autoregulation in diabetic patients with cardiovascular autonomic neuropathy and orthostatic hypotension},
	url = {https://m2.mtmt.hu/api/publication/20145683},
	author = {Mankovsky, B N and Piolot, R and Mankovsky, O L and Ziegler, D},
	doi = {10.1046/j.1464-5491.2003.00885.x},
	journal-iso = {DIABETIC MED},
	journal = {DIABETIC MEDICINE},
	volume = {20},
	unique-id = {20145683},
	issn = {0742-3071},
	year = {2003},
	eissn = {1464-5491},
	pages = {119-126}
}

@article{MTMT:1052888,
	title = {Acetazolamide as a vasodilatory stimulus in cerebrovascular diseases and in conditions affecting the cerebral vasculature},
	url = {https://m2.mtmt.hu/api/publication/1052888},
	author = {Settakis, G and Molnár, Csilla and Kerenyi, L and Kollár, József and Legemate, D and Csiba, László and Fülesdi, Béla},
	doi = {10.1046/j.1468-1331.2003.00675.x},
	journal-iso = {EUR J NEUROL},
	journal = {EUROPEAN JOURNAL OF NEUROLOGY},
	volume = {10},
	unique-id = {1052888},
	issn = {1351-5101},
	abstract = {Pathologic processes affecting the brain vessels may damage cerebral vasodilatory capacity. Early detection of cerebral dysfunction plays an important role in the prevention of cerebrovascular diseases. In recent decades acetazolamide (AZ) has frequently been used for this purpose. In the present work the mechanism of action and the previous studies are reviewed. The authors conclude that AZ tests are useful in cerebrovascular research. Further investigations are recommended to prove how impaired reserve capacity and reactivity influence the stroke risk in patients and whether these tests may indicate therapeutic interventions.},
	year = {2003},
	eissn = {1468-1331},
	pages = {609-620}
}

@article{MTMT:1052899,
	title = {No correlation between impairment of cerebro-vascular reserve capacity and electrophysiologically assessed severity of neuropathy in noninsulin-dependent diabetes mellitus},
	url = {https://m2.mtmt.hu/api/publication/1052899},
	author = {Hidasi, Eszter and Káplár, Miklós and Diószeghy, Péter and Bereczki, Dániel and Csiba, László and Limburg, M and Fülesdi, Béla},
	doi = {10.1016/S1056-8727(01)00181-7},
	journal-iso = {J DIABETES COMPLICAT},
	journal = {JOURNAL OF DIABETES AND ITS COMPLICATIONS},
	volume = {16},
	unique-id = {1052899},
	issn = {1056-8727},
	abstract = {INTRODUCTION: Microvascular abnormalities have an important role in the most frequent neurological complications of diabetes mellitus: neuropathy and cerebrovascular disorders. Severity of neuropathy as well as of cerebral microvascular damage can be quantitatively evaluated by instrumental methods like nerve conduction studies and transcranial Doppler. In the present study, we investigated whether a correlation exists between the severity of peripheral neuropathy and the impairment of cerebrovascular reserve capacity (CRC) in 20 patients with Type 2 diabetes mellitus. METHODS: CRC was measured by transcranial Doppler and defined as the maximal percentage increase in blood flow velocity in the middle cerebral artery within 20 min after an intravenous dose of 1000 mg of acetazolamide. Nerve conduction studies of the median, ulnar, peroneal, and sural nerves were performed. Severity of neuropathy was scored based on conduction velocities, amplitudes, and distal latencies. RESULTS: There was no correlation between the neuropathic score and CRC (R= .003, P= .99). Neither CRC nor the neuropathic score correlated significantly with age, duration of diabetes, and serum values of HbA(1c), glucose, insulin, von Willebrand factor, and alpha(2) - macroglobulin. Severity of neuropathy but not CRC correlated with microalbuminuria (R= .47, P= .038 and R= .14, P= .54). Improper treatment reflected by HbA(1c) >10% was associated with significantly more severe albuminuria, higher actual blood glucose level, higher von Willebrand factor activity, and marginally higher neuropathic score (21 vs. 13, P=.096), but was not associated with CRC (44% vs. 42%, P= .81). When duration of diabetes was dichotomized to 15 years and less or over 15 years, CRC was significantly smaller (35% vs. 50%, P= .036) and neuropathy was more severe in the subgroup with longer diabetes duration (19 vs. 11.5 points, P= .07). CONCLUSIONS: Although both CRC and peripheral nerve function are affected more severely in patients with long-lasting Type 2 diabetes mellitus, damage in the cerebrovascular system and in the long peripheral nerves occur independently. As in diabetes mellitus pathological changes in autonomic and large peripheral nerves develop simultaneously, decreased CRC in diabetic patients might be predominantly due to structural changes of resistance arteries or to metabolic than to neurogenic factors.},
	year = {2002},
	eissn = {1873-460X},
	pages = {228-234},
	orcid-numbers = {Bereczki, Dániel/0000-0002-8374-0500}
}