@article{MTMT:33841808, title = {Continuous non-invasive estimates of cerebral blood flow using electrocardiography signals: a feasibility study}, url = {https://m2.mtmt.hu/api/publication/33841808}, author = {van Bohemen, Samuel J. J. and Rogers, Jeffrey M. M. and Boughton, Philip C. C. and Clarke, Jillian L. L. and Valderrama, Joaquin T. T. and Kyme, Andre Z. Z.}, doi = {10.1007/s13534-023-00265-z}, journal-iso = {BIOMED ENG LETT}, journal = {BIOMEDICAL ENGINEERING LETTERS}, volume = {13}, unique-id = {33841808}, issn = {2093-9868}, abstract = {This paper describes a potential method to detect changes in cerebral blood flow (CBF) using electrocardiography (ECG) signals, measured across scalp electrodes with reference to the same signal across the chest-a metric we term the Electrocardiography Brain Perfusion index (EBPi). We investigated the feasibility of EBPi to monitor CBF changes in response to specific tasks. Twenty healthy volunteers wore a head-mounted device to monitor EBPi and electroencephalography (EEG) during tasks known to alter CBF. Transcranial Doppler (TCD) ultrasound measurements provided ground-truth estimates of CBF. Statistical analyses were applied to EBPi, TCD right middle cerebral artery blood flow velocity (rMCAv) and EEG relative Alpha (rAlpha) data to detect significant task-induced changes and correlations. Breath-holding and aerobic exercise induced highly significant increases in EBPi and TCD rMCAv (p < 0.01). Verbal fluency also increased both measures, however the increase was only significant for EBPi (p < 0.05). Hyperventilation induced a highly significant decrease in TCD rMCAv (p < 0.01) but EBPi was unchanged. Combining all tasks, EBPi exhibited a highly significant, weak positive correlation with TCD rMCAv (r = 0.27, p < 0.01) and the Pearson coefficient between EBPi and rAlpha was r = - 0.09 (p = 0.05). EBPi appears to be responsive to dynamic changes in CBF and, can enable practical, continuous monitoring. CBF is a key parameter of brain health and function but is not easily measured in a practical, continuous, non-invasive fashion. EBPi may have important clinical implications in this context for stroke monitoring and management. Additional studies are required to support this claim.}, keywords = {Electrocardiography; Electroencephalography; stroke; cerebral blood flow; Continuous monitoring; quantitative electroencephalography}, year = {2023}, eissn = {2093-985X}, pages = {185-195} } @article{MTMT:34583611, title = {Enhancing diffuse correlation spectroscopy pulsatile cerebral blood flow signal with near-infrared spectroscopy photoplethysmography}, url = {https://m2.mtmt.hu/api/publication/34583611}, author = {Wu, Kuan Cheng and Martin, Alyssa and Renna, Marco and Robinson, Mitchell and Ozana, Nisan and Carp, Stefan A. and Franceschini, Maria Angela}, doi = {10.1117/1.NPh.10.3.035008}, journal-iso = {NEUROPHOTONICS}, journal = {NEUROPHOTONICS}, volume = {10}, unique-id = {34583611}, issn = {2329-423X}, abstract = {Significance: Combining near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS) allows for quantifying cerebral blood volume, flow, and oxygenation changes continuously and non-invasively. As recently shown, the DCS pulsatile cerebral blood flow index (pCBFi) can be used to quantify critical closing pressure (CrCP) and cerebrovascular resistance (CVRi).Aim: Although current DCS technology allows for reliable monitoring of the slow hemodynamic changes, resolving pulsatile blood flow at large source-detector separations, which is needed to ensure cerebral sensitivity, is challenging because of its low signal-to-noise ratio (SNR). Cardiac-gated averaging of several arterial pulse cycles is required to obtain a meaningful waveform.Approach: Taking advantage of the high SNR of NIRS, we demonstrate a method that uses the NIRS photoplethysmography (NIRS-PPG) pulsatile signal to model DCS pCBFi, reducing the coefficient of variation of the recovered pulsatile waveform (pCBF(i-fit)) and allowing for an unprecedented temporal resolution (266 Hz) at a large source-detector separation (>3 cm).Results: In 10 healthy subjects, we verified the quality of the NIRS-PPG pCBF(i-fit) during common tasks, showing high fidelity against pCBF(i) (R-2 0.98 +/- 0.01). We recovered CrCP and CVRi at 0.25 Hz, >10 times faster than previously achieved with DCS.Conclusions: NIRS-PPG improves DCS pCBF(i) SNR, reducing the number of gate-averaged heartbeats required to recover CrCP and CVRi.}, keywords = {near-infrared spectroscopy; cerebral blood flow; Diffuse correlation spectroscopy; cerebrovascular resistance; Critical closing pressure}, year = {2023}, eissn = {2329-4248}, orcid-numbers = {Martin, Alyssa/0000-0003-3007-250X; Robinson, Mitchell/0000-0001-5810-0459} } @article{MTMT:32935670, title = {Cerebral Hemodynamic Reserve Abnormalities Detected Via Transcranial Doppler Ultrasound in Recovered COVID-19 Patients}, url = {https://m2.mtmt.hu/api/publication/32935670}, author = {Antonio Abdo-Cuza, Anselmo and Hall-Smith, Charles and Suarez-Lopez, Juliette and Castellanos-Gutierrez, Roberto and Angel Blanco-Gonzalez, Miguel and Machado-Martinez, Rafael and Pi-Avila, Jonathan and Gomez-Peire, Francisco and Espinosa-Nodarse, Namibia and Lopez-Gonzalez, Juan C.}, doi = {10.37757/MR2022.V24.N1.3}, journal-iso = {MEDICC REV}, journal = {MEDICC REVIEW}, volume = {24}, unique-id = {32935670}, issn = {1555-7960}, abstract = {INTRODUCTION SARS-CoV-2 infection can produce endothelial injury and microvascular damage, one cause of the multiorgan failure associated with COVID-19. Cerebrovascular endothelial damage increases the risk of stroke in COVID-19 patients, which makes prompt diagnosis important. Endothelial dysfunction can be evaluated by using transcranial Doppler ultrasound to study cerebral hemodynamic reserve, but there are few of these studies in patients with COVID-19, and the technique is not included in COVID-19 action and follow-up guidelines nationally or internationally. OBJECTIVE Estimate baseline cerebral hemodynamic patterns, cerebral hemodynamic reserve, and breath-holding index in recovered COVID-19 patients. METHOD We conducted an exploratory study in 51 people; 27 men and 24 women 20-78 years of age, divided into two groups. One group comprised 25 recovered COVID-19 patients, following clinical and epidemiological discharge, who suffered differing degrees of disease severity, and who had no neurological symptoms or disease at the time they were incorporated into the study. The second group comprised 26 people who had not been diagnosed with COVID-19 and who tested negative by RT-PCR at the time of study enrollment. Recovered patients were further divided into two groups: those who had been asymptomatic or had mild disease, and those who had severe or critical disease. We performed transcranial Doppler ultrasounds to obtain baseline and post-apnea tests of cerebral hemodynamic patterns to evaluate cerebral hemodynamic reserve and breath-holding indices. We characterized the recovered patient group and the control group through simple descriptive statistics (means and standard deviations). RESULTS There were no measurable differences in baseline cerebral hemodynamics between the groups. However, cerebral hemodynamic reserve and breath-holding index were lower in those who had COVID-19 than among control participants (19.9% vs. 36.8% and 0.7 vs. 1.2 respectively). These variables were similar for patients who had asymptomatic or mild disease (19.9% vs.19.8%) and for those who had severe or critical disease (0.7 vs. 0.7). CONCLUSIONS Patients recovered from SARS-CoV-2 infection showed decreased cerebral hemodynamic reserve and breath-holding index regardless of the disease's clinical severity or presence of neurological symptoms. These abnormalities may be associated with endothelial damage caused by COVID-19. It would be useful to include transcranial Doppler ultrasound in evaluation and follow-up protocols for patients with COVID-19.}, keywords = {ENDOTHELIUM; CUBA; vascular; Cerebrovascular Circulation; Ultrasonography; Doppler; breath holding; transcranial; COVID-19; SARS-CoV-2}, year = {2022}, eissn = {1527-3172}, pages = {28-31} } @article{MTMT:32935669, title = {Cerebral Blood Flow Autoregulation Measurement via Bioimpedance Technology}, url = {https://m2.mtmt.hu/api/publication/32935669}, author = {Chen, Jia and Ke, Li and Du, Qiang and Zheng, Yawen and Liu, Yanan}, doi = {10.1109/TIM.2022.3169544}, journal-iso = {IEEE T INSTRUM MEAS}, journal = {IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT}, volume = {71}, unique-id = {32935669}, issn = {0018-9456}, abstract = {Background: Cerebral blood flow (CBF) auto-regulation function is essential for evaluating CBF status. This article provides an evaluation method of CBF using bioimpedance. Method: A mathematical model of cerebral vascular compliance is established to analyze the effect of autoregulation ability changes on the impedance of CBF. The synchronization signals of impedance and blood pressure are measured, and the peak phase shift is extracted to evaluate the cerebral blood autoregulation function. Results: The experiment results show that the peak phase shift can express the cerebral autoregulation change process. The frontal and occipital region's peak phase shift changes are 10.32%-37.6% and 11.18%-36.86%, respectively. Significant: The proposed approach could build the relationship between CBF autoregulation and impedance, and this method is noninvasive, continuous, and easy to execute. This study provides a basis for the health assessment of the CBF system using bioimpedance.}, keywords = {BLOOD; Mathematical models; IMPEDANCE; CONDUCTIVITY; blood flow; BIOIMPEDANCE; Automobiles; Impedance measurement; cerebrovascular compliance; blood flow wave analysis; cerebral blood flow (CBF) autoregulation; peak phase shift}, year = {2022}, eissn = {1557-9662}, orcid-numbers = {Chen, Jia/0000-0003-2958-7696} } @article{MTMT:33164779, title = {Cerebral hemodynamic changes to transcranial Doppler sonography in celiac disease: A pilot study}, url = {https://m2.mtmt.hu/api/publication/33164779}, author = {Fisicaro, Francesco and Lanza, Giuseppe and D'Agate, Carmela Cinzia and Pennisi, Manuela and Cantone, Mariagiovanna and Pennisi, Giovanni and Hadjivassiliou, Marios and Bella, Rita}, doi = {10.3389/fnhum.2022.931727}, journal-iso = {FRONT HUM NEUROSCI}, journal = {FRONTIERS IN HUMAN NEUROSCIENCE}, volume = {16}, unique-id = {33164779}, issn = {1662-5161}, abstract = {BackgroundSonographic mesenteric pattern in celiac disease (CD) suggests a hyperdynamic circulation. Despite the well-known CD-related neurological involvement, no study has systematically explored the cerebral hemodynamics to transcranial Doppler sonography. Materials and methodsMontreal Cognitive Assessment (MoCA) and 17-item Hamilton Depression Rating Scale (HDRS) were assessed in 15 newly diagnosed subjects with CD and 15 age-, sex-, and education-matched healthy controls. Cerebral blood flow (CBF) velocities and indices of resistivity (RI) and pulsatility (PI) from the middle cerebral artery (MCA), bilaterally, and the basilar artery (BA) were recorded. We also assessed cerebral vasomotor reactivity (CVR) through the breath-holding test (BHT). ResultsWorse scores of MoCA and HDRS were found in patients compared to controls. Although patients showed higher values of CBF velocity from MCA bilaterally compared to controls, both at rest and after BHT, no comparison reached a statistical significance, whereas after BHT both RI and PI from BA were significantly higher in patients. A significant negative correlation between both indices from BA and MoCA score were also noted. ConclusionThese treatment-naive CD patients may show some subtle CVR changes in posterior circulation, thus possibly expanding the spectrum of pathomechanisms underlying neuroceliac disease and in particular gluten ataxia. Subclinical identification of cerebrovascular pathology in CD may help adequate prevention and early management of neurological involvement.}, keywords = {DEPRESSION; cognition; celiac disease; cerebral blood flow; Cerebral hemodynamics; VASOMOTOR REACTIVITY; transcranial doppler sonography}, year = {2022}, eissn = {1662-5161}, orcid-numbers = {Cantone, Mariagiovanna/0000-0002-9072-4971} } @article{MTMT:32788817, title = {The scalability of common paradigms for assessment of cognitive function: A functional transcranial Doppler study}, url = {https://m2.mtmt.hu/api/publication/32788817}, author = {Intharakham, K. and Panerai, R.B. and Robinson, T.G.}, doi = {10.1371/journal.pone.0266048}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {17}, unique-id = {32788817}, issn = {1932-6203}, abstract = {Cognitive paradigms induce changes in cerebral blood flow (CBF) associated with increased metabolic demand, namely neurovascular coupling (NVC). We tested the hypothesis that the effect of complexity and duration of cognitive paradigms will either enhance or inhibit the NVC response. Bilateral CBF velocity (CBFV) in the middle cerebral arteries (MCAs) via transcranial Doppler ultrasound (TCD), blood pressure (BP), electrocardiogram (ECG) and end-tidal CO2 (EtCO2) of 16 healthy participants (aged 21–71 years) were simultaneously recorded at rest and during randomized paradigms of different complexities (naming words beginning with P-,R-,V- words and serial subtractions of 100–2,100–7,1000–17), and durations (5s, 30s and 60s). CBFV responses were population mean normalized from a 30-s baseline period prior to task initiation. A significant increase in bilateral CBFV response was observed at the start of all paradigms and provided a similar pattern in most responses, irrespective of complexity or duration. Although significant inter-hemispherical differences were found during performance of R-word and all serial subtraction paradigms, no lateralisation was observed in more complex naming word tasks. Also, the effect of duration was manifested at late stages of 100–7, but not for other paradigms. CBFV responses could not distinguish different levels of complexity or duration with a single presentation of the cognitive paradigm. Further studies of the ordinal scalability of the NVC response are needed with more advanced modelling techniques, or different types of neural stimulation. © 2022 Intharakham et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.}, year = {2022}, eissn = {1932-6203} } @article{MTMT:33618502, title = {Cerebral blood flow regulation is not acutely altered after a typical number of headers in women footballers}, url = {https://m2.mtmt.hu/api/publication/33618502}, author = {Jack, Jacob and Woodgates, Alex and Smail, Oliver and Brown, Felix and Lynam, Katie and Lester, Alice and Williams, Genevieve and Bond, Bert}, doi = {10.3389/fneur.2022.1021536}, journal-iso = {FRONT NEUR}, journal = {FRONTIERS IN NEUROLOGY}, volume = {13}, unique-id = {33618502}, issn = {1664-2295}, abstract = {Background: The repeated act of heading has been implicated in the link between football participation and risk of neurodegenerative disease, and acutely alters cerebrovascular outcomes in men. This study assessed whether exposure to a realistic number of headers acutely influences indices of cerebral blood flow regulation in female footballers. Methods: Nineteen female players completed a heading trial and seated control trial on two separate days. The heading trial involved six headers in 1 h (one every 10 min), with the ball traveling at 40 +/- 5 km/h. Cerebrovascular reactivity to hypercapnia and hypocapnia was determined using serial breath holding and hyperventilation attempts. Dynamic cerebral autoregulation (dCA) was assessed by scrutinizing the relationship between cerebral blood flow and mean arterial blood pressure during 5 min of squat stand maneuvers at 0.05 Hz. Neurovascular coupling (NVC) was quantified as the posterior cerebral artery blood velocity response to a visual search task. These outcomes were assessed before and 1 h after the heading or control trial. Results: No significant time by trial interaction was present for the hypercapnic (P = 0.48, eta p2 = 0.05) and hypocapnic (P = 0.47, eta p2 = 0.06) challenge. Similarly, no significant interaction effect was present for any metric of dCA (P > 0.12, eta p2 < 0.16 for all) or NVC (P > 0.14, eta p2 < 0.15 for all). Conclusion: The cerebral blood flow response to changes in carbon dioxide, blood pressure and a visual search task were not altered following six headers in female footballers. Further study is needed to observe whether changes are apparent after more prolonged exposure.}, keywords = {DYSFUNCTION; IMPAIRMENT; CARBON-DIOXIDE; Carbon Dioxide; Cerebrovascular reactivity; Cerebrovascular reactivity; SEX-DIFFERENCES; AUTOREGULATION; AUTOREGULATION; Soccer; SOCCER PLAYERS; Transcranial Doppler ultrasound; Clinical Neurology; CO2 REACTIVITY}, year = {2022}, eissn = {1664-2295} } @article{MTMT:33164778, title = {The acute effect of exercise intensity on peripheral and cerebral vascular function in healthy adults}, url = {https://m2.mtmt.hu/api/publication/33164778}, author = {Weston, Max E. and Koep, Jodie L. and Lester, Alice B. and Barker, Alan R. and Bond, Bert}, doi = {10.1152/japplphysiol.00772.2021}, journal-iso = {J APPL PHYSIOL}, journal = {JOURNAL OF APPLIED PHYSIOLOGY}, volume = {133}, unique-id = {33164778}, issn = {8750-7587}, abstract = {The acute effect of exercise intensity on cerebrovascular reactivity and whether this mirrors changes in peripheral vascular function have not been investigated. The aim of this study was to explore the acute effect of exercise intensity on cerebrovascular reactivity (CVR) and peripheral vascular function in healthy young adults (n = 10, 6 females, 22.7 +/- 3.5 yr). Participants completed four experimental conditions on separate days: high-intensity interval exercise (HIIE) with intervals performed at 75% maximal oxygen uptake (<(V) over dot>O-2max; HIIE1), HIIE with intervals performed at 90% <(V) over dot>O-2max (HIIE2), continuous moderate-intensity exercise (MIE) at 60% <(V) over dot>O-2max and a sedentary control condition (CON). All exercise conditions were completed on a cycle ergometer and matched for time (30 min) and average intensity (60% <(V) over dot>O-2max). Brachial artery flow-mediated dilation (FMD) and CVR of the middle cerebral artery were measured before exercise, and 1- and 3-h after exercise. CVR was assessed using transcranial Doppler ultrasonography to both hypercapnia (6% carbon dioxide breathing) and hypocapnia (hyperventilation). FMD was significantly elevated above baseline 1 and 3 h following both HIIE conditions (P < 0.05), but FMD was unchanged following the MIE and CON trials (P > 0.33). CVR to both hypercapnia and hypocapnia, and when expressed across the end-tidal CO2 range, was unchanged in all conditions, at all time points (all P > 0.14). In conclusion, these novel findings show that the acute increases in peripheral vascular function following HIIE, compared with MIE, were not mirrored by changes in cerebrovascular reactivity, which was unaltered following all exercise conditions in healthy young adults.NEW & NOTEWORTHY This is the first study to identify that acute improvements in peripheral vascular function following highintensity interval exercise are not mirrored by improvements in cerebrovascular reactivity in healthy young adults. High-intensity interval exercise completed at both 75% and 90% <(V) over dot>O-2max increased brachial artery flow-mediated dilation 1 and 3 h following exercise, compared with continuous moderate-intensity exercise and a sedentary control condition. By contrast, cerebrovascular reactivity was unchanged following all four conditions.}, keywords = {Cerebrovascular reactivity; flow-mediated dilation; endothelial function; HIIE}, year = {2022}, eissn = {1522-1601}, pages = {461-470}, orcid-numbers = {Bond, Bert/0000-0003-3597-8562} } @article{MTMT:33164781, title = {Open-source FlexNIRS: A low-cost, wireless and wearable cerebral health tracker}, url = {https://m2.mtmt.hu/api/publication/33164781}, author = {Wu, Kuan-Cheng and Tamborini, Davide and Renna, Marco and Peruch, Adriano and Huang, Yujing and Martin, Alyssa and Kaya, Kutlu and Starkweather, Zachary and Zavriyev, Alexander I and Carp, Stefan A. and Salat, David H. and Franceschini, Maria Angela}, doi = {10.1016/j.neuroimage.2022.119216}, journal-iso = {NEUROIMAGE}, journal = {NEUROIMAGE}, volume = {256}, unique-id = {33164781}, issn = {1053-8119}, abstract = {Currently, there is great interest in making neuroimaging widely accessible and thus expanding the sampling population for better understanding and preventing diseases. The use of wearable health devices has skyrocketed in recent years, allowing continuous assessment of physiological parameters in patients and research cohorts. While most health wearables monitor the heart, lungs and skeletal muscles, devices targeting the brain are currently lacking. To promote brain health in the general population, we developed a novel, low-cost wireless cerebral oximeter called FlexNIRS. The device has 4 LEDs and 3 photodiode detectors arranged in a symmetric geometry, which allows for a self-calibrated multi-distance method to recover cerebral hemoglobin oxygenation (SO2) at a rate of 100 Hz. The device is powered by a rechargeable battery and uses Bluetooth Low Energy (BLE) for wireless communication. We developed an Android application for portable data collection and real-time analysis and display. Characterization tests in phantoms and human participants show very low noise (noise-equivalent power <70 fW/root Hz) and robustness of SO2 quantification in vivo. The estimated cost is on the order of $50/unit for 1000 units, and our goal is to share the device with the research community following an open-source model. The low cost, ease-of-use, smart-phone readiness, accurate SO2 quantification, real time data quality feedback, and long battery life make prolonged monitoring feasible in low resource settings, including typically medically underserved communities, and enable new community and telehealth applications.}, keywords = {NIRS; Bluetooth Low Energy; wearable device; Community health; CEREBRAL OXIMETRY}, year = {2022}, eissn = {1095-9572}, orcid-numbers = {Kaya, Kutlu/0000-0002-1826-4659; Zavriyev, Alexander I/0000-0003-3383-0724} } @article{MTMT:32236942, title = {Blood markers of endothelial dysfunction and their correlation to cerebrovascular reactivity in patients with chronic hepatitis C infection}, url = {https://m2.mtmt.hu/api/publication/32236942}, author = {Ivelja, Mirela Pavicic and Dolic, Kresimir and Tandara, Leida and Perkovic, Nikola and Mestrovic, Antonio and Ivic, Ivo}, doi = {10.7717/peerj.10723}, journal-iso = {PEERJ}, journal = {PEERJ}, volume = {9}, unique-id = {32236942}, issn = {2167-8359}, abstract = {Although liver cirrhosis and hepatocellular carcinoma are major consequences of hepatitis C (HCV), there has been an increasing number of studies examining extrahepatic manifestations, especially those caused by systemic chronic inflammation and metabolic complications that might predispose HCV patients to atherosclerosis and ischemic cerebrovascular disease (CVD). The aim of our study was to assess E-selectin, VCAM-1, ICAM-1 and VEGF-A serum levels in patients with chronic HCV infection and to correlate them with cerebrovascular reactivity. A blood sample was taken from eighteen patients with chronic hepatitis C infection and from the same number of healthy blood donors in the control group. The aim was to analyse markers of endothelial dysfunction and to correlate them with cerebrovascular reactivity expressed as breath-holding index (BHI) determined using transcranial color Doppler. The obtained results revealed significant differences between the groups in all endothelial markers except for the E selectin. While the ICAM-1 and sVCAM-1 were significantly increased in the hepatitis group, VEGF-A was significantly decreased. A significant reduction of 0.5 (95% CI 0.2, 0.8) in the mean BHI was found in the hepatitis group (mean BHI 0.64) compared to controls (mean BHI 1.10). No significant association between the BHI and any of the endothelial markers was found in the control group, while in the hepatitis group, the scatter plot of ICAM-1 vs BHI suggested that the association might be present. In conclusion, the results of this study confirm an association between a chronic HCV infection and altered cerebrovascular reactivity as well as higher levels of markers of endothelial activation (ICAM-1, VCAM-1) as possible indicators of an increased CVD risk.}, keywords = {Inflammation; ATHEROSCLEROSIS; HEPATITIS; Biomarkers; Diagnostic Imaging; Cerebrovascular Disorders}, year = {2021}, eissn = {2167-8359} } @article{MTMT:31991553, title = {The effect of propofol-sufentanil intravenous anesthesia on systemic and cerebral circulation, cerebral autoregulation and CO2 reactivity – a case-series}, url = {https://m2.mtmt.hu/api/publication/31991553}, author = {Véghné Juhász, Marianna Beáta and Páll, Dénes and Fülesdi, Béla and Molnár, Levente and Végh, Tamás and Molnár, Csilla}, doi = {10.1016/j.bjane.2021.04.002}, journal-iso = {BRAZ J ANESTH}, journal = {BRAZILIAN JOURNAL OF ANESTHESIOLOGY}, volume = {71}, unique-id = {31991553}, issn = {0104-0014}, abstract = {Background and objectives The aim of our study was to assess systemic and cerebral hemodynamic changes as well as cerebral CO2-reactivity during propofol anesthesia. Methods 27 patients undergoing general anesthesia were enrolled. Anesthesia was maintained using the Target-Controlled Infusion (TCI) method according to the Schnider model, effect site propofol concentration of 4 μg.mL-1. Ventilatory settings (respiratory rate and tidal volume) were adjusted to reach and maintain 40, 35 and 30 mmHg EtCO2 for 5-minutes, respectively. At the end of each period, transcranial Doppler and hemodynamic parameters using applanation tonometry were recorded. Results Systemic mean arterial pressure significantly decreased during anesthetic induction and remained unchanged during the entire study period. Central aortic and peripherial pulse pressure did not change significantly during anesthetic induction and maintenance, whereas augmentation index as marker of arterial stiffness significantly decreased during the anesthetic induction and remained stable at the time points when target CO2 levels were reached. Both cerebral autoregulation and cerebral CO2-reactivity was maintained during propofol anesthesia. Conclusions Propofol at clinically administered doses using the Total Intravenous Anesthesia (TIVA/TCI) technique decreases systemic blood pressure, but does not affect static cerebral autoregulation, flow-metabolism coupling and cerebrovascular CO2 reactivity. According to our measurements, propofol may exert its systemic hemodynamic effect through venodilation. Trial registration The study was registered at http://www.clinicaltrials.gov, identifier: NCT02203097, registration date: July 29, 2014.}, keywords = {Propofol, Cerebral blood flow; Cerebral autoregulation; CO2-reactivity; Applanation tonometry; Transcranial Doppler}, year = {2021}, pages = {558-564}, orcid-numbers = {Fülesdi, Béla/0000-0003-2541-9740} } @article{MTMT:32236941, title = {Cerebral Vasoreactivity Evaluated by Transcranial Color Doppler and Breath-Holding Test in Patients after SARS-CoV-2 Infection}, url = {https://m2.mtmt.hu/api/publication/32236941}, author = {Marcic, Marino and Marcic, Ljiljana and Marcic, Barbara and Capkun, Vesna and Vukojevic, Katarina}, doi = {10.3390/jpm11050379}, journal-iso = {J PERS MED}, journal = {JOURNAL OF PERSONALIZED MEDICINE}, volume = {11}, unique-id = {32236941}, abstract = {From the beginning of the SARS-CoV-2 virus pandemic, it was clear that the virus is highly neurotrophic. Neurological manifestations can range from nonspecific symptoms such as dizziness, headaches and olfactory disturbances to severe forms of neurological dysfunction. Some neurological complication can occur even after mild forms of respiratory disease. This study's aims were to assess cerebrovascular reactivity in patients with nonspecific neurological symptoms after SARS-CoV-2 infection. A total of 25 patients, aged 33-62 years, who had nonspecific neurological symptoms after SARS-CoV-2 infection, as well as 25 healthy participants in the control group, were assessed for cerebrovascular reactivity according to transcranial color Doppler (TCCD) which we combined with a breath-holding test (BHT). In subjects after SARS-CoV-2 infection, there were statistically significantly lower flow velocities through the middle cerebral artery at rest period, lower maximum velocities at the end of the breath-holding period and lower breath holding index (BHI) in relation to the control group. Changes in cerebral artery flow rate velocities indicate poor cerebral vasoreactivity in the group after SARS-CoV-2 infection in regard to the control group and suggest vascular endothelial damage by the SARS-CoV-2 virus.}, keywords = {vasoreactivity; Transcranial color Doppler; SARS-CoV-2; nonspecific neurological symptoms}, year = {2021}, eissn = {2075-4426}, orcid-numbers = {Vukojevic, Katarina/0000-0003-2182-2890} } @article{MTMT:32591656, title = {Cerebral Vasoreactivity Changes Over Time in Patients With Different Clinical Manifestations of Cerebral Small Vessel Disease}, url = {https://m2.mtmt.hu/api/publication/32591656}, author = {Staszewski, J. and Dȩbiec, A. and Skrobowska, E. and Stȩpień, A.}, doi = {10.3389/fnagi.2021.727832}, journal-iso = {FRONT AGING NEUROSCI}, journal = {FRONTIERS IN AGING NEUROSCIENCE}, volume = {13}, unique-id = {32591656}, issn = {1663-4365}, abstract = {Objectives: Endothelial dysfunction (ED) has been linked to the pathogenesis of cerebral small vessel disease (SVD). We aimed to assess ED and cerebrovascular reactivity (CVR) in the patients with a diverse manifestation of SVD, with similar and extensive white matter lesions (WMLs, modified Fazekas scale grade ≥2), compared with a control group (CG) without the MRI markers of SVD, matched for age, gender, hypertension, diabetes, and to evaluate the change of CVR following 24 months. Methods: We repeatedly measured the vasomotor reactivity reserve (VMRr) and breath-holding index (BHI) of the middle cerebral artery (MCA) by the transcranial Doppler ultrasound (TCD) techniques in 60 subjects above 60 years with a history of lacunar stroke (LS), vascular dementia (VaD), or parkinsonism (VaP) (20 in each group), and in 20 individuals from a CG. Results: The mean age, frequency of the main vascular risk factors, and sex distribution were similar in the patients with the SVD groups and a CG. The VMRr and the BHI were more severely impaired at baseline (respectively, 56.7 ± 18% and 0.82 ± 0.39) and at follow-up (respectively, 52.3 ± 16.7% and 0.71 ± 0.38) in the patients with SVD regardless of the clinical manifestations (ANOVA, p > 0.1) than in the CG (respectively, baseline VMRr 77.2 ± 15.6%, BHI 1.15 ± 0.47, p < 0.001; follow-up VMRr 74.3 ± 17.6%, BHI 1.11 ± 0.4, p < 0.001). All the assessed CVR measures (VMRr and BHI) significantly decreased over time in the subjects with SVD (Wilcoxon's signed-rank test p = 0.01), but this was not observed in the CG (p > 0.1) and the decrease of CVR measures was not related to the SVD radiological progression (p > 0.1). Conclusions: This study provided evidence that the change in CVR measures is detectable over a 24-month period in patients with different clinical manifestations of SVD. Compared with the patients in CG with similar atherothrombotic risk factors, all the CVR measures (BMRr and BHI) significantly declined over time in the subjects with SVD. The reduction in CVR was not related to the SVD radiological progression. © Copyright © 2021 Staszewski, Dȩbiec, Skrobowska and Stȩpień.}, keywords = {endothelial dysfunction; Neurovascular coupling; cerebral small vessel disease; neurovascular unit (NVU); cerebrovascular reactivity (CVR)}, year = {2021}, eissn = {1663-4365} } @article{MTMT:31692182, title = {A Breath-Holding Index Applied to the Internal Carotid Artery Siphon in Transcranial Doppler Studies}, url = {https://m2.mtmt.hu/api/publication/31692182}, author = {Jung, Kyu-On and Lee, Seung-Jae and Lee, Tae-Kyeong}, doi = {10.1111/jon.12752}, journal-iso = {J NEUROIMAGING}, journal = {JOURNAL OF NEUROIMAGING}, volume = {30}, unique-id = {31692182}, issn = {1051-2284}, abstract = {BACKGROUND AND PURPOSE The breath-holding index (BHI) is a useful method to assess cerebrovascular reactivity. It is calculated based on the mean flow velocities of the middle cerebral artery (MCA) using transcranial Doppler (BHIMCA). Therefore, it is not feasible in patients with poor temporal windows. This study tested the feasibility of a BHI using the internal carotid artery (ICA) siphon flow velocity (BHIICA). METHODS Twenty-four patients (aged 38-79 years) with unilateral or bilateral stenosis of the cervical ICAs were prospectively recruited. The 48 examined bilateral ICAs were divided into three groups according to the stenosis degree: <50%, 50-99%, and occlusion. We investigated the reproducibility of both BHI methods (BHI(MCA)and BHIICA), the correlation between the two BHI methods, and the tendency for the BHIs to decrease with increasing degree of cervical ICA stenosis. RESULTS For the BHIMCA, we found a good reproducibility (intraclass correlation coefficient,r(I)( )> .9())and a significantly decreased BHI with increasing stenosis of the ICA (P= .001). For the BHIICA, good reproducibility was demonstrated (r(I) > or approximately equal to or the image of .9), but there was no significant decrease in the BHI related to the increasing degree of ICA stenosis (P= .952). Furthermore, the correlation between the two BHI methods was not robust (kappa coefficient, right .259; left .619). CONCLUSIONS Our study suggests that the BHI(ICA)is not a feasible alternative method to the BHIMCA.}, keywords = {Cerebrovascular reactivity; TRANSCRANIAL DOPPLER; internal carotid artery; breath-holding index}, year = {2020}, eissn = {1552-6569}, pages = {862-866}, orcid-numbers = {Lee, Seung-Jae/0000-0003-2299-4870} } @article{MTMT:31425520, title = {The reliability of a breath-hold protocol to determine cerebrovascular reactivity in adolescents}, url = {https://m2.mtmt.hu/api/publication/31425520}, author = {Koep, Jodie L. and Barker, Alan R. and Banks, Rhys and Banger, Rohit R. and Sansum, Kate M. and Weston, Max E. and Bond, Bert}, doi = {10.1002/jcu.22891}, journal-iso = {J CLIN ULTRASOUND}, journal = {JOURNAL OF CLINICAL ULTRASOUND}, volume = {48}, unique-id = {31425520}, issn = {0091-2751}, abstract = {Purpose Cerebrovascular reactivity (CVR) is impaired in adolescents with cardiovascular disease risk factors. A breath-hold test is a noninvasive method of assessing CVR, yet there are no reliability data of this outcome in youth. This study aimed to assess the reliability of a breath-hold protocol to measure CVR in adolescents. Methods Twenty-one 13 to 15 year old adolescents visited the laboratory on two separate occasions, to assess the within-test, within-day and between-day reliability of a breath-hold protocol, consisting of three breath-hold attempts. CVR was defined as the relative increase from baseline in middle cerebral artery mean blood velocity following a maximal breath-hold of up to 30 seconds, quantified via transcranial Doppler ultrasonography. Results Mean breath-hold duration and CVR were never significantly correlated (r< .31,P> .08). The within-test coefficient of variation for CVR was 15.2%, with no significant differences across breath-holds (P= .88), so the three breath-hold attempts were averaged for subsequent analyses. The within- and between-day coefficients of variation for CVR were 10.8% and 15.3%, respectively. Conclusions CVR assessed via a three breath-hold protocol can be reliably measured in adolescents, yielding similar within- and between-day reliability. Analyses revealed that breath-hold length and CVR were unrelated, indicating the commonly reported normalization of CVR to breath-hold duration (breath-hold index) may be unnecessary in youth.}, keywords = {reproducibility; endothelial function; Youth; cerebral blood flow; Transcranial Doppler ultrasound; hypercapnic stimulus}, year = {2020}, eissn = {1097-0096}, pages = {544-552}, orcid-numbers = {Bond, Bert/0000-0003-3597-8562} } @article{MTMT:31425571, title = {Cerebrovascular Reactivity in Special Operations Forces Combat Soldiers}, url = {https://m2.mtmt.hu/api/publication/31425571}, author = {Roby, Patricia R. and Chandran, Avinash and Barczak-Scarboro, Nikki E. and DeLellis, Stephen M. and Ford, Cassie B. and Healy, Marshall L. and Means, Gary E. and Kane, Shawn F. and Lynch, James H. and Mihalik, Jason P.}, doi = {10.1007/s10439-020-02514-z}, journal-iso = {ANN BIOMED ENG}, journal = {ANNALS OF BIOMEDICAL ENGINEERING}, volume = {48}, unique-id = {31425571}, issn = {0090-6964}, abstract = {The purpose of this study was to investigate how concussion history affects cerebrovascular reactivity (CVR) in Special Operations Forces (SOF) combat soldiers. We studied 104 SOF soldiers [age = 33.5 +/- 4.3 years; height = 179.7 +/- 6.3 cm; 59 (56.7%) with self-reported concussion history]. We employed transcranial Doppler (TCD) ultrasound to measure middle cerebral artery (MCA) velocity. Baseline TCD data were collected for 2 min. Changes in MCA velocity were measured in response to five breath-holding trials and five hyperventilation trials. Cerebrovascular reactivity was quantified by the breath-holding index (BHI), vasomotor reactivity reserve (VMRr), and percent change in overall response curves. Independent t tests were employed to assess group differences in BHI, and VMRr values. We employed mixed effects models with quadratic mean structures to assess group differences in percent change MCA velocity response curves. There were no significant group differences in BHI (t(102) = 0.04, p = 0.97) or VMRr (t(102) = -0.33, p = 0.75). There were no group differences in relative MCA velocity response curves during the breath-holding task (F-1,F-5092 = 0.19, p = 0.66) or during the hyperventilation task (F-1,F-5092 = 0.41, p = 0.52) between SOF soldiers with and without a self-reported concussion history. If CVR deficits exist immediately post-concussion, our study suggests that these deficits recover over time in this population. While long-term neurophysiological effects of blast-related injury are currently unknown, assessing CVR response may provide further insight into cerebrovascular function and overall physiological health following blast exposure.}, keywords = {neurophysiology; Mild traumatic brain injury; CEREBROVASCULAR FUNCTION; blast injury; military}, year = {2020}, eissn = {1573-9686}, pages = {1651-1660} } @article{MTMT:31659363, title = {Cerebral hemodynamic changes to transcranial doppler in asymptomatic patients with fabry’s disease}, url = {https://m2.mtmt.hu/api/publication/31659363}, author = {Vagli, C. and Fisicaro, F. and Vinciguerra, L. and Puglisi, V. and Rodolico, M.S. and Giordano, A. and Ferri, R. and Lanza, G. and Bella, R.}, doi = {10.3390/brainsci10080546}, journal-iso = {BRAIN SCI}, journal = {BRAIN SCIENCES}, volume = {10}, unique-id = {31659363}, abstract = {Background: Patients with Fabry’s disease (FD) may be asymptomatic or show a spectrum of clinical manifestations, including cerebrovascular disease, mainly affecting posterior circulation. Few and conflicting studies on cerebral blood flow (CBF) velocity by transcranial Doppler sonography (TCD) in asymptomatic FD (aFD) subjects have been published. Our study aims to assess TCD in aFD subjects to identify any preclinical CBF change. Methods: A total of 30 aFD subjects were consecutively recruited and compared to 28 healthy controls. Brain magnetic resonance imaging was normal in all participants. TCD was used to study blood flow velocity and indices of resistance of intracranial arteries from the middle cerebral artery (MCA), bilaterally, and from the basilar artery (BA). Cerebral vasomotor reactivity (CVR) was also evaluated from MCA. Results: No difference was found between groups for MCA parameters of CBF velocity and CVR. Compared to controls, a higher mean blood flow velocity and a lower resistance index from BA were observed in FD subjects. No correlation was found between any BA‐derived TCD parameter and the level of lyso‐globotriaosylceramide. Conclusions: aFD subjects show evidence of altered CBF velocity in posterior circulation. Preclinical detection of neurovascular involvement in FD might allow appropriate management and prevention of future cerebrovascular complications and disability. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.}, keywords = {cerebrovascular disease; TRANSCRANIAL DOPPLER; White matter lesions; cerebral blood flow; Cerebral hemodynamics; Fabry's disease}, year = {2020}, eissn = {2076-3425} } @article{MTMT:30879787, title = {Evaluation of cerebrovascular reactivity in chronic hepatitis C patients using transcranial color Doppler}, url = {https://m2.mtmt.hu/api/publication/30879787}, author = {Ivelja, Mirela Pavicic and Ivic, Ivo and Dolic, Kresimir and Mestrovic, Antonio and Perkovic, Nikola and Jankovic, Stipan}, doi = {10.1371/journal.pone.0218206}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {14}, unique-id = {30879787}, issn = {1932-6203}, abstract = {Hepatitis C viral (HCV) infection is associated with systemic inflammation and metabolic complications that might predispose patients to atherosclerosis, including cerebrovascular atherosclerosis. The aim of this study was to assess cerebrovascular reactivity in patients with chronic hepatitis C. Seventeen patients with chronic hepatitis C infection, as well as 11 healthy blood donors in the control group, were assessed for cerebrovascular reactivity according to the well-established breath-holding test that uses the transcranial color Doppler for measurement of blood flow velocity. Results obtained during the breath-holding revealed significantly lower average peak systolic (AvPS start, P = 0.018), end-diastolic (AvED start, P = 0.031) and mean velocity values at the very beginning of the breath-holding procedure (AvmeanV start, P = 0.02), as well as a lower mean peak systolic velocity at the end of the breath-holding test (AvPS max, P = 0.02) in the hepatitis C group. Vascular reactivity values, calculated as the breath-holding index, were also significantly lower (P = 0.045) in the hepatitis C group. In conclusion, the results of this study suggest an association between chronic HCV infection and altered cerebrovascular reactivity which may ultimately have an unfavorable effect on cerebrovascular hemodynamics and lead to increased risk of cerebrovascular diseases.}, year = {2019}, eissn = {1932-6203} } @article{MTMT:30716379, title = {Effect of sevoflurane on systemic and cerebral circulation, cerebral autoregulation and CO2 reactivity}, url = {https://m2.mtmt.hu/api/publication/30716379}, author = {Véghné Juhász, Marianna Beáta and Molnár, Levente and Fülesdi, Béla and Végh, Tamás and Páll, Dénes and Molnár, Csilla}, doi = {10.1186/s12871-019-0784-9}, journal-iso = {BMC ANESTHESIOL}, journal = {BMC ANESTHESIOLOGY}, volume = {19}, unique-id = {30716379}, issn = {1471-2253}, keywords = {CO2-reactivity;applanation tonometry; Cerebral blood flow; cerebral autoregulation; Sevoflurane; Transcranial Doppler}, year = {2019}, eissn = {1471-2253} } @article{MTMT:30879789, title = {Hyperventilation and breath-holding test with indocyanine green kinetics predicts cerebral hyperperfusion after carotid artery stenting}, url = {https://m2.mtmt.hu/api/publication/30879789}, author = {Nakagawa, Ichiro and Yokoyama, Shohei and Wajima, Daisuke and Nishimura, Fumihiko and Yamada, Shuichi and Yokota, Hiroshi and Motoyama, Yasushi and Park, Young Su and Wada, Takeshi and Kichikawa, Kimihiko and Nakase, Hiroyuki}, doi = {10.1177/0271678X17743878}, journal-iso = {J CEREBR BLOOD F MET}, journal = {JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM}, volume = {39}, unique-id = {30879789}, issn = {0271-678X}, abstract = {Cerebral hyperperfusion syndrome (CHS) is a serious complication following carotid artery stenting (CAS), but definitive early prediction of CHS has not been established. Here, we evaluated whether indocyanine green kinetics and near-infrared spectroscopy (ICG-NIRS) with hyperventilation (HV) and the breath-holding (BH) test can predict hyperperfusion phenomenon after CAS. The blood flow index (BFI) ratio during HV and BH was prospectively monitored using ICG-NIRS in 66 patients scheduled to undergo CAS. Preoperative cerebrovascular reactivity (CVR) and the postoperative asymmetry index (AI) were also assessed with single-photon emission computed tomography before and after CAS and the correlation with the BFI HV/rest ratio, BFI BH/rest ratio was evaluated. Twelve cases (18%) showed hyperperfusion phenomenon, and one (1.5%) showed CHS after CAS. A significant linear correlation was observed between the BFI HV/rest ratio, BFI BH/rest ratio, and preoperative CVR. A significant linear correlation was observed between the BFI HV/rest ratio and postoperative AI (r = 0.674, P < 0.0001). A BFI HV/rest ratio of 0.88 or more was the optimal cut-off point to predict hyperperfusion phenomenon according to receiver operating characteristic curve analyses. HV and BH test under ICG-NIRS is a useful tool for detection of hyperperfusion phenomenon in patients who underwent CAS.}, keywords = {Carotid artery stenting; near-infrared spectroscopy; indocyanine green; Hyperperfusion syndrome; hyperventilation test}, year = {2019}, eissn = {1559-7016}, pages = {901-912} } @article{MTMT:30879783, title = {Is There a Role for Transcranial Doppler Ultrasound for Patients after Traumatic Brain Injury?}, url = {https://m2.mtmt.hu/api/publication/30879783}, author = {Razumovsky, A.}, doi = {10.4103/ajns.AJNS_42_19}, journal-iso = {NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS}, journal = {NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS}, volume = {15}, unique-id = {30879783}, issn = {1312-6431}, abstract = {Neurologists, neurosurgeons, and neurointensivists have a large armamentarium of diagnostic and monitoring devices available to detect primary and secondary brain injury and guide therapy in patients with acute traumatic brain injury (TBI) to avoid cerebral ischemia due to the posttraumatic vasospasm (PTV) and intracranial hypertension (ICH). This review summarizes the advantages and the specific roles of transcranial Doppler (TCD) ultrasonography for patients with acute and long-term effects of TBI. In critical care setting abundant number of publications showed that TCD is predictive of angiographic PTV and onset of ICH. The post TBI status of cerebrovascular reactivity and cerebral hemodynamics also has important implications with regard to the treatment of long-term effects of mild TBI (mTBI). Today there is abundant evidence that TCD is an important tool for monitoring the natural course of acute, moderate and severe TBI, for evaluating the effect of medical treatment or intervention, for forecasting, and for identifying high-risk patients for onset of cerebral ischemia after TBI.There is a potential for much broader utilization of TCD for patients after mild, moderate and severe TBI. TCD makes good clinical and economic sense, as it is a reliable, quantitative and non-expensive "biomarker" to the acute clinical manifestations of moderate and severe TBI and long-term effects of concussion or mTBI. TCD clinical utilization holds promise for better detection, characterization, and monitoring of objective cerebral hemodynamics changes in symptomatic patients with TBI not readily apparent by standard CT or conventional MRI techniques. TCD utilization will improve the sensitivity of neuroimaging to subtle brain perturbations and combining these objective measures with careful clinical characterization of patients may facilitate better understanding of the neural bases and treatment of the signs and symptoms of TBI (mild, moderate and severe). TCD is a fast and reliable efficient ultrasound technology and has a greater value to improve the management of patients with acute and non-acute TBI.}, keywords = {traumatic brain injury; TRANSCRANIAL DOPPLER; Cerebral vasospasm}, year = {2019}, pages = {82-89} } @article{MTMT:30879794, title = {Non-invasive methods for measuring vascular changes in neurovascular headaches}, url = {https://m2.mtmt.hu/api/publication/30879794}, author = {Schytz, Henrik W. and Amin, Faisal M. and Selb, Juliette and Boas, David A.}, doi = {10.1177/0271678X17724138}, journal-iso = {J CEREBR BLOOD F MET}, journal = {JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM}, volume = {39}, unique-id = {30879794}, issn = {0271-678X}, abstract = {Vascular changes during spontaneous headache attacks have been studied over the last 30 years. The interest in cerebral vessels in headache research was initially due to the hypothesis of cerebral vessels as the pain source. Here, we review the knowledge gained by measuring the cerebral vasculature during spontaneous primary headache attacks with the use of single photon emission tomography (SPECT), positron emission tomography (PET), magnetic resonance imaging (MRA) and transcranial Doppler (TCD). Furthermore, the use of near-infrared spectroscopy in headache research is reviewed. Existing TCD studies of migraine and other headache disorders do not provide solid evidence for cerebral blood flow velocity changes during spontaneous attacks of migraine headache. SPECT studies have clearly shown cortical vascular changes following migraine aura and the differences between migraine with aura compared to migraine without aura. PET studies have shown focal activation in brain structures related to headache, but whether the changes are specific to different primary headaches have yet to be demonstrated. MR angiography has shown precise changes in large cerebral vessels during spontaneous migraine without aura attacks. Future development in more precise imaging methods may further elucidate the pathophysiological mechanisms in primary headaches.}, keywords = {MIGRAINE; Cortical spreading depression; neuroimaging; vascular changes and headache}, year = {2019}, eissn = {1559-7016}, pages = {633-649} } @article{MTMT:30879689, title = {Cerebral and Extracerebral Vasoreactivity in Patients With Different Clinical Manifestations of Cerebral Small-Vessel Disease: Data From the Significance of Hemodynamic and Hemostatic Factors in the Course of Different Manifestations of Cerebral Small-Vessel Disease Study}, url = {https://m2.mtmt.hu/api/publication/30879689}, author = {Staszewski, Jacek and Skrobowska, Ewa and Piusinska-Macoch, Renata and Brodacki, Bogdan and Stepien, Adam}, doi = {10.1002/jum.14782}, journal-iso = {J ULTRAS MED}, journal = {JOURNAL OF ULTRASOUND IN MEDICINE}, volume = {38}, unique-id = {30879689}, issn = {0278-4297}, abstract = {Objectives Endothelial dysfunction has been implicated in the pathogenesis of cerebral small-vessel disease (SVD). Little is known about the relationship between SVD and measures of endothelium-dependent vasodilatation and cerebral vasomotor reactivity. The aim of this study was to evaluate cerebral and extracerebral endothelial dysfunction in patients with different manifestations of SVD and to assess the relationship between endothelial dysfunction and radiologic markers of SVD. Methods The vasomotor reactivity reserve (VMRr), breath-holding index (BHI) of the middle cerebral arteries, and brachial artery flow-mediated dilatation (FMD) were measured with ultrasound techniques in 90 patients (30 in each group) older than 60 years with extensive white matter lesions (Fazekas grade >= 2) with a history of lacunar stroke, vascular dementia, or parkinsonism and 30 individuals with normal magnetic resonance imaging findings (control group). All groups were matched for age, sex, hypertension, and diabetes. Results The mean age +/- SD (71.8 +/- 3.4 versus 71.7 +/- 3.4 years), sex distribution, and prevalence of the main vascular risk factors were similar in the SVD and control groups. The VMRr (56.6% +/- 18.3% versus 77.1% +/- 16.9%), BHI (0.8 +/- 0.3 versus 1.1 +/- 0.4), and FMD (5.8% +/- 4 versus 12.1% +/- 5.2%) were severely impaired in the SVD groups compared to the control group (P < .01). The vascular responses to all tests was similar in the SVD groups, but they were significantly decreased in patients with severe white matter lesions, marked brain atrophy, and enlarged perivascular spaces. Conclusions This study was the first that simultaneously evaluated cerebral and extracerebral vasodilator responses in a well-phenotyped cohort of patients with lacunar stroke, vascular dementia, or parkinsonism. The VMRr, BHI, and FMD were more severely impaired in patients with SVD, regardless of its clinical manifestation, than in control participants. All measures were significantly lower in patients with severe white-matter lesions, brain atrophy, or enlarged perivascular spaces.}, keywords = {endothelial dysfunction; Cerebrovascular reactivity; cerebral small vessel disease; Vascular ultrasound; brachial artery flow-mediated dilatation; vasomotor reactivity reserve}, year = {2019}, eissn = {1550-9613}, pages = {975-987} } @article{MTMT:30879803, title = {The Breath-Hold Acceleration Index: A New Method to Evaluate Cerebrovascular Reactivity using Transcranial Doppler}, url = {https://m2.mtmt.hu/api/publication/30879803}, author = {Alwatban, Mohammed and Truemper, Edward J. and Al-rethaia, Abdullah and Murman, Daniel L. and Bashford, Gregory R.}, doi = {10.1111/jon.12508}, journal-iso = {J NEUROIMAGING}, journal = {JOURNAL OF NEUROIMAGING}, volume = {28}, unique-id = {30879803}, issn = {1051-2284}, abstract = {BACKGROUND AND PURPOSECerebrovascular reactivity (CR) is an ideal biomarker to detect cerebrovascular damage. CR can be quantified by measuring changes in cerebral blood flow velocity (CBFV) resulting from a CO(2)vasodilatory stimulus, often using the breath-holding index (BHI). In this method, transcranial Doppler (TCD) ultrasound is used to measure CBFV changes in the middle cerebral artery (MCA) during a breath-hold maneuver. Despite its convenience, BHI has high variability. Changing body position may contribute to potential variability. It is important to determine if CR differs with body position. The aims of this study were, first, to propose an alternative, more robust index to evaluate CR using a breath-hold maneuver; second, investigate the effect of body position on CR measured with conventional (BHI) and a new proposed index.METHODSTen healthy young volunteers held their breath for 30 seconds on a tilt table. CR was calculated at five different angles using two indices: the conventional BHI, and the breath-hold acceleration index (BHAI), a new index obtained by linear regression of the most linear portion of the mean velocity change during the breath-hold maneuver. The regression represents acceleration (change in blood flow velocity per unit of time) sampled at each cardiac cycle.RESULTSThe mean coefficient of variation was 43.7% lower in BHAI in comparison with BHI. Neither index was statistically significant between body positions (P > .05).CONCLUSIONSBHAI has less variability in comparison with the conventional standard BHI. Additionally, neither index showed statistical significance in CR based on change in body position.}, keywords = {Cerebrovascular reactivity; Transcranial Doppler ultrasound; breath-holding index}, year = {2018}, eissn = {1552-6569}, pages = {429-435} } @article{MTMT:30466846, title = {Transcranial Doppler in Management of Asymptomatic Carotid Stenosis}, url = {https://m2.mtmt.hu/api/publication/30466846}, author = {Arokszallasi, T. and Olah, L.}, journal-iso = {NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS}, journal = {NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS}, volume = {14}, unique-id = {30466846}, issn = {1312-6431}, abstract = {There have been contradictions regarding the optimal treatment of patients with asymptomatic severe internal carotid artery stenosis (ACAS). From the one hand previous studies proved benefit from carotid intervention in ACAS patients, from the other hand due to the development of modern medical therapy there has been a significant reduction in stroke incidence in patients with only medical treatment. Recent calculations have suggested that the stroke risk with intensive medical therapy is lower or similar compared with that of carotid endarterectomy or carotid artery stenting in ACAS patients. Therefore, carotid reconstruction for the most patients with asymptomatic severe internal carotid artery stenosis has not been suggested recently. However, some special subgroups with high stroke risk were shown to benefit from carotid surgery. High-risk patients are characterised by poor collateral circulation with exhausted cerebrovascular reserve capacity, or by unstable plaque with cerebral microembolisation. The present article summarizes the use of transcranial Doppler in selection of high-risk ACAS patients who may benefit from carotid intervention.}, keywords = {stroke; TRANSCRANIAL DOPPLER; Cerebral vasoreactivity; Asymptomatic carotid stenosis; cerebrovascular reserve capacity; microembolus signal}, year = {2018}, pages = {88-95} } @article{MTMT:30879804, title = {A Cross-Sectional Study on Cerebral Hemodynamics After Mild Traumatic Brain Injury in a Pediatric Population}, url = {https://m2.mtmt.hu/api/publication/30879804}, author = {Thibeault, Corey M. and Thorpe, Samuel and O'Brien, Michael J. and Canac, Nicolas and Ranjbaran, Mina and Patanam, Ilyas and Sarraf, Artin and LeVangie, James and Scalzo, Fabien and Wilk, Seth J. and Diaz-Arrastia, Ramon and Hamilton, Robert B.}, doi = {10.3389/fneur.2018.00200}, journal-iso = {FRONT NEUR}, journal = {FRONTIERS IN NEUROLOGY}, volume = {9}, unique-id = {30879804}, issn = {1664-2295}, abstract = {The microvasculature is prominently affected by traumatic brain injury (TBI), including mild TBI (concussion). Assessment of cerebral hemodynamics shows promise as biomarkers of TBI, and may help inform development of therapies aimed at promoting neurologic recovery. The objective of this study was to assess the evolution in cerebral hemodynamics observable with transcranial Doppler (TCD) ultrasound in subjects suffering from a concussion at different intervals during recovery. Pediatric subjects between the ages of 14 and 19 years clinically diagnosed with a concussion were observed at different points post-injury. Blood flow velocity in the middle cerebral artery was measured with TCD. After a baseline period, subjects participated in four breath holding challenges. Pulsatility index (PI), resistivity index (RI), the ratio of the first two pulse peaks (P2R), and the mean velocity (MV) were computed from the baseline section. The breath hold index (BHI) was computed from the challenge sections. TCD detected two phases of hemodynamic changes after concussion. Within the first 48 h, PI, RI, and P2R show a significant difference from the controls (U = -3.10; P < 0.01, U = -2.86; P < 0.01, and U = 2.62; P < 0.01, respectively). In addition, PI and P2R were not correlated (rp = -0.36; P = 0.23). After 48 h, differences in pulsatile features were no longer observable. However, BHI was significantly increased when grouped as 2-3, 4-5, and 6-7 days post-injury (U = 2.72; P < 0.01, U = 2.46; P = 0.014, and U = 2.38; P = 0.018, respectively). To our knowledge, this is the first longitudinal study of concussions using TCD. In addition, these results are the first to suggest the multiple hemodynamic changes after a concussion are observable with TCD and could ultimately lead to a better understanding of the underlying pathophysiology. In addition, the different hemodynamic responses to a concussion as compared to severe traumatic brain injuries highlight the need for specific diagnostic and therapeutic treatments of mild head injuries in adolescents.}, keywords = {traumatic brain injury; blood flow; vascular reactivity; cerebral blood flow autoregulation; cerebral blood flow velocity}, year = {2018}, eissn = {1664-2295} } @article{MTMT:26567280, title = {Cerebral endothelial dysfunction in reversible cerebral vasoconstriction syndrome: a case-control study}, url = {https://m2.mtmt.hu/api/publication/26567280}, author = {Choi, Hyun Ah and Lee, Mi Ji and Chung, Chin-Sang}, doi = {10.1186/s10194-017-0738-x}, journal-iso = {J HEADACHE PAIN}, journal = {JOURNAL OF HEADACHE AND PAIN}, volume = {18}, unique-id = {26567280}, issn = {1129-2369}, year = {2017}, eissn = {1129-2377} } @article{MTMT:26974387, title = {Cerebral vasoreactivity: Concordance of breath holding test and acetazolamide injection in current practice: 20 cases of asymptomatic carotid artery stenosis}, url = {https://m2.mtmt.hu/api/publication/26974387}, author = {De Bortoli, M. and Maillet, A. and Skopinski, S. and Sassoust, G. and Constans, J. and Boulon, C.}, doi = {10.1016/j.jdmv.2017.06.002}, journal-iso = {JMV}, journal = {JMV-JOURNAL DE MEDECINE VASCULAIRE}, volume = {42}, unique-id = {26974387}, issn = {2542-4513}, year = {2017}, pages = {272-281} } @article{MTMT:26751465, title = {Cerebral vasomotor reactivity in reversible cerebral vasoconstriction syndrome}, url = {https://m2.mtmt.hu/api/publication/26751465}, author = {Topcuoglu, Mehmet Akif and Chan, Suk-tak and Silva, Gisele Sampaio and Smith, Eric Edward and Kwong, Kenneth K and Singhal, Aneesh Bhim}, doi = {10.1177/0333102416650706}, journal-iso = {CEPHALALGIA}, journal = {CEPHALALGIA}, volume = {37}, unique-id = {26751465}, issn = {0333-1024}, year = {2017}, eissn = {1468-2982}, pages = {541-547} } @article{MTMT:26227518, title = {Assessment of cerebral embolism and vascular reserve parameters in patients with carotid artery stenosis}, url = {https://m2.mtmt.hu/api/publication/26227518}, author = {Puz, Przemyslaw and Lasek-Bal, Anetta and Urbanek, Tomasz and Kazibutowska, Zofia}, doi = {10.1016/j.pjnns.2016.06.004}, journal-iso = {NEUROL NEUROCHIR POL}, journal = {NEUROLOGIA I NEUROCHIRURGIA POLSKA}, volume = {50}, unique-id = {26227518}, issn = {0028-3843}, year = {2016}, eissn = {1897-4260}, pages = {356-362} } @article{MTMT:25478260, title = {Near infrared spectroscopy - investigations in neurovascular diseases}, url = {https://m2.mtmt.hu/api/publication/25478260}, author = {Schytz, Henrik Winther}, journal-iso = {DAN MED J}, journal = {DANISH MEDICAL JOURNAL}, volume = {62}, unique-id = {25478260}, year = {2015}, eissn = {2245-1919} } @inproceedings{MTMT:30879811, title = {Risk factors of unfavorable course of cerebral small vessel disease - preliminary data from SHEF-CSVD Study}, url = {https://m2.mtmt.hu/api/publication/30879811}, author = {Staszewski, J. and Skrobowska, E. and Piusinska-Macoch, R. and Brodacki, B. and Stepien, A.}, booktitle = {9TH INTERNATIONAL CONGRESS ON VASCULAR DEMENTIA (ICVD 2015)}, unique-id = {30879811}, abstract = {Natural clinical course of cerebral small vessel disease (CSVD) has not yet been thoroughly described. The aim of the single center, prospective study being a part of SHEF-CSVD Study was to establish risk factors of unfavorable course of CSVD in 24 months follow-up. 137 functionally independent patients with marked MRI features of CSVD and with recent lacunar stroke (n=47, LS), 28 with vascular Parkinsonism (VaP), 42 with vascular dementia (VaD), 20 with deep hemorrhagic stroke and 44 controls (CG) matched for age, sex and vascular risk factors were prospectively recruited. Brain MRI was performed at the study entry and after 24 month of follow-up. Unfavorable course was defined as occurrence of death, any vascular events or progression of MRI white matter lesions (WMLs) during observation. Blood markers of endothelial dysfunction and inflammation and cerebral vasomotor reactivity (VMRr) in response to hypercapnia using TCD examination were determined. Unfavorable outcome was more frequent in CSVD group vs CG (32% vs 9%, p<0.01). Independent of age risk factors associated with poor outcome were: baseline MMSE <23 p, VMRr <53%, hsCRP >0,69 mg/L, serum albumin level <3,45 g/dL, tissue factor >61, 75 ng/ml, severe WMLs (modified Fazekas score >= 2p), lack of statin and aspirin use, no physical activity and nocturnal blood pressure fall.}, keywords = {Prognosis; SMALL VESSEL DISEASE; hemodynamic and hemostatic risk factors}, year = {2015}, pages = {19-22} } @article{MTMT:24694988, title = {Diabetic symmetric polyneuropathy is associated with increased aortal stiffening but not cerebral angiopathy in type 1 diabetes}, url = {https://m2.mtmt.hu/api/publication/24694988}, author = {Szczyrba, S and Kozera, GM and Neubauer-Geryk, J and Wolnik, B and Nyka, WM and Bieniaszewski, L}, doi = {10.1016/j.jdiacomp.2014.10.002}, journal-iso = {J DIABETES COMPLICAT}, journal = {JOURNAL OF DIABETES AND ITS COMPLICATIONS}, volume = {29}, unique-id = {24694988}, issn = {1056-8727}, year = {2015}, eissn = {1873-460X}, pages = {73-76} } @article{MTMT:2466072, title = {Blood flow velocity changes in anterior cerebral arteries during cognitive tasks performance}, url = {https://m2.mtmt.hu/api/publication/2466072}, author = {Boban, Marina and Črnac, Petra and Junaković, Anamari and Garami, Zsolt and Malojčić, Branko}, doi = {10.1016/j.bandc.2013.10.006}, journal-iso = {BRAIN COGNITION}, journal = {BRAIN AND COGNITION}, volume = {84}, unique-id = {2466072}, issn = {0278-2626}, abstract = {AbstractObjective Transcranial Doppler sonography (TCD) enables monitoring of blood flow velocities (BFVs) in basal cerebral arteries during different cognitive tasks performance with great temporal resolution. So far, BFVs changes during mental activity were monitored primarily in middle cerebral arteries (MCAs) and little is known about these changes in anterior cerebral arteries (ACAs). Aim To determine the effect of different cognitive tasks performance on BFV changes and hemispheric dominance in ACAs and to assess the most suitable activation test for monitoring of BFV changes in ACAs. Methods Fourteen right-handed, healthy subjects aged 20–26 were included in the study. BFVs in both ACAs were recorded simultaneously during performance of cognitive tasks designed to activate frontal lobes: phonemic verbal fluency test (pVFT), Stroop tests and Trail Making Tests (TMTs). Results A statistically significant BFV increase was recorded in both ACAs during performance of all cognitive tasks. Statistically significant right ACA dominance was found during performance of pVFT and TMTB. The most significant BFV increase was obtained during performance of TMTB. Conclusion Our result addressed cognitive tests with great activation potential for monitoring of ACAs that might be used in distinguishing of healthy individuals and patients with neurovascular or neurodegenerative diseases.}, keywords = {cognition; TRANSCRANIAL DOPPLER; verbal fluency; anterior cerebral artery; Trail Making; Stroop}, year = {2014}, eissn = {1090-2147}, pages = {26-33} } @article{MTMT:24862856, title = {Hemodynamic monitoring of middle cerebral arteries during cognitive tasks performance}, url = {https://m2.mtmt.hu/api/publication/24862856}, author = {Boban, Marina and Crnac, Petra and Junakovic, Anamari and Malojcic, Branko}, doi = {10.1111/pcn.12191}, journal-iso = {PSYCHIAT CLIN NEUROS}, journal = {PSYCHIATRY AND CLINICAL NEUROSCIENCES}, volume = {68}, unique-id = {24862856}, issn = {1323-1316}, year = {2014}, eissn = {1440-1819}, pages = {795-803} } @article{MTMT:23718365, title = {Relationship of obesity and insulin resistance with the cerebrovascular reactivity: A case control study}, url = {https://m2.mtmt.hu/api/publication/23718365}, author = {Rodríguez-Flores, M and García-García, E and Cano-Nigenda, CV and Cantú-Brito, C}, doi = {10.1186/1475-2840-13-2}, journal-iso = {CARDIOVASC DIABETOL}, journal = {CARDIOVASCULAR DIABETOLOGY}, volume = {13}, unique-id = {23718365}, issn = {1475-2840}, year = {2014}, eissn = {1475-2840} } @article{MTMT:23718367, title = {Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: Extra-cerebral contributions}, url = {https://m2.mtmt.hu/api/publication/23718367}, author = {Mesquita, RC and Schenkel, SS and Minkoff, DL and Lu, X and Favilla, CG and Vora, PM and Busch, DR and Chandra, M and Greenberg, JH and Detre, JA and Yodh, AG}, doi = {10.1364/BOE.4.000978}, journal-iso = {BIOMED OPT EXPRESS}, journal = {BIOMEDICAL OPTICS EXPRESS}, volume = {4}, unique-id = {23718367}, issn = {2156-7085}, year = {2013}, pages = {978-994} } @article{MTMT:23138456, title = {Effect of clustering of metabolic syndrome factors on capillary and cerebrovascular impairment}, url = {https://m2.mtmt.hu/api/publication/23138456}, author = {Nazzaro, P and Schirosi, G and Mezzapesa, D and Petruzzellis, M and Pascazio, L and Serio, G and De Benedittis, L and Federico, F}, doi = {10.1016/j.ejim.2012.08.017}, journal-iso = {EUR J INTERNAL MED}, journal = {EUROPEAN JOURNAL OF INTERNAL MEDICINE}, volume = {24}, unique-id = {23138456}, issn = {0953-6205}, year = {2013}, eissn = {1879-0828}, pages = {183-188} } @article{MTMT:2501419, title = {Effects of GSM 900 MHz on Middle Cerebral Artery Blood Flow Assessed by Transcranial Doppler Sonography}, url = {https://m2.mtmt.hu/api/publication/2501419}, author = {Ghosn, R and Thuróczy, György and Loos, N and Brenet-Dufour, V and Liabeuf, S and de Seze, R and Selmaoui, B}, doi = {10.1667/RR3007.1}, journal-iso = {RADIAT RES}, journal = {RADIATION RESEARCH}, volume = {178}, unique-id = {2501419}, issn = {0033-7587}, year = {2012}, eissn = {1938-5404}, pages = {543-550} } @article{MTMT:2239290, title = {Cerebral vasoreactivity in white coat hypertension - response}, url = {https://m2.mtmt.hu/api/publication/2239290}, author = {Fülesdi, Béla and Páll, Dénes}, doi = {10.1111/j.1468-1331.2011.03483.x}, journal-iso = {EUR J NEUROL}, journal = {EUROPEAN JOURNAL OF NEUROLOGY}, volume = {18}, unique-id = {2239290}, issn = {1351-5101}, year = {2011}, eissn = {1468-1331}, pages = {E135-E135} } @article{MTMT:22457084, title = {Cerebrovascular reactivity impairment after sport-induced concussion}, url = {https://m2.mtmt.hu/api/publication/22457084}, author = {Len, T K and Neary, J P and Asmundson, G J G and Goodman, D G and Bjornson, B and Bhambhani, Y N}, doi = {10.1249/MSS.0b013e3182249539}, journal-iso = {MED SCI SPORT EXER}, journal = {MEDICINE AND SCIENCE IN SPORTS AND EXERCISE}, volume = {43}, unique-id = {22457084}, issn = {0195-9131}, year = {2011}, eissn = {1530-0315}, pages = {2241-2248} } @{MTMT:25440146, title = {Indications and Contraindications for Carotid Artery Stenting in Asymptomatic Patients: The case for risk stratification}, url = {https://m2.mtmt.hu/api/publication/25440146}, author = {Moussa, ID}, booktitle = {The Carotid and Supra-Aortic Trunks: Diagnosis, Angioplasty and Stenting: 2nd Edition}, doi = {10.1002/9781444329803.ch18}, publisher = {Wiley-Blackwell Publishing Ltd.}, unique-id = {25440146}, year = {2011}, pages = {152-158} } @article{MTMT:1894308, title = {Impaired cerebral vasoreactivity in white coat hypertensive adolescents}, url = {https://m2.mtmt.hu/api/publication/1894308}, author = {Páll, Dénes and Lengyel, S and Komonyi, E and Molnár, Csilla and Paragh, György and Fülesdi, Béla and Katona, Éva Melitta}, doi = {10.1111/j.1468-1331.2010.03209.x}, journal-iso = {EUR J NEUROL}, journal = {EUROPEAN JOURNAL OF NEUROLOGY}, volume = {18}, unique-id = {1894308}, issn = {1351-5101}, abstract = {BACKGROUND AND PURPOSE: Although its incidence is not high, adolescent hypertension may predict hypertension and increased cardiovascular risk in adulthood. Therefore, the aim of the present study was to assess whether cerebrovascular reactivity is altered in adolescent white coat and sustained hypertensive patients compared to healthy teenagers. METHODS: Fifty-nine normotensive, 47 white coat hypertensive (WCH), and 73 sustained hypertensive (SH) adolescents were studied. WCH and SH were differentiated by ambulatory blood pressure monitoring. Cerebrovascular reactivity was assessed by transcranial Doppler breath-holding test and was expressed in percent (%) change to the resting cerebral blood flow velocity value. RESULTS: The percent increase in middle cerebral artery mean blood flow velocity after 30 s of breath holding was lower in both WCH (5.3 +/- 3.1%) and SH (9.5 +/- 2.6%) groups indicating lower vasodilatory reactivity compared to healthy adolescents (12.1 +/- 2.2%). Additionally, serum nitric oxide (NOx) concentrations were lower in both WCH (30.6 +/- 11 muM) and SH (30.7 +/- 22.4 muM) groups compared to controls (38.8 +/- 7.6 muM). Conclusions: Both white coat and sustained hypertension result in decreased vasodilatory reaction to CO(2) in adolescents, suggesting involvement of the cerebral arterioles. The present study underlines the importance of early recognition and proper treatment of adolescent hypertension in order to prevent long-term cardiovascular complications.}, keywords = {Adolescent; Female; Male; Humans; Ultrasonography, Doppler, Transcranial; Cerebrovascular Circulation/*physiology; Brain/*blood supply; Blood Flow Velocity; Blood Pressure Monitoring, Ambulatory; Hypertension/*physiopathology}, year = {2011}, eissn = {1468-1331}, pages = {584-589} } @article{MTMT:25602091, title = {Feeling Lightheaded: The Role of Cerebral Blood Flow}, url = {https://m2.mtmt.hu/api/publication/25602091}, author = {Bresseleers, Johan and Van, Diest Ilse and De Peuter, Steven and Verhamme, Peter and Van, den Bergh Omer}, doi = {10.1097/PSY.0b013e3181e68e94}, journal-iso = {PSYCHOSOM MED}, journal = {PSYCHOSOMATIC MEDICINE}, volume = {72}, unique-id = {25602091}, issn = {0033-3174}, year = {2010}, eissn = {1534-7796}, pages = {672-680} } @article{MTMT:21038236, title = {The Long-Term Effect of Four Hours of Hyperventilation on Neurocognitive Performance and Lesion Size After Controlled Cortical Impact in Rats}, url = {https://m2.mtmt.hu/api/publication/21038236}, author = {Eberspacher, E and Blobner, M and Werner, C and Ruf, S and Eckel, B and Engelhard, K and Schmahl, W and Gelb, AW}, doi = {10.1213/ANE.0b013e3181c2203b}, journal-iso = {ANESTH ANALG}, journal = {ANESTHESIA AND ANALGESIA}, volume = {110}, unique-id = {21038236}, issn = {0003-2999}, year = {2010}, eissn = {1526-7598}, pages = {181-187} } @article{MTMT:22457236, title = {Cerebral vasomotor reactivity and extent of white matter lesions in middle-aged men with arterial hypertension: A pilot study}, url = {https://m2.mtmt.hu/api/publication/22457236}, author = {Kozera, G M and Dubaniewicz, M and Zdrojewski, T and Madej-Dmochowska, A and Mielczarek, M and Wojczal, J and Chwojnicki, K and Swierblewska, E and Schminke, U and Wyrzykowski, B and Nyka, W M}, doi = {10.1038/ajh.2010.152}, journal-iso = {AM J HYPERTENS}, journal = {AMERICAN JOURNAL OF HYPERTENSION}, volume = {23}, unique-id = {22457236}, issn = {0895-7061}, year = {2010}, eissn = {1941-7225}, pages = {1198-1203} } @article{MTMT:22457090, title = {Assessment of breath holding index during orthostasis}, url = {https://m2.mtmt.hu/api/publication/22457090}, author = {Bago-Rožanković, P and Lovrenčić-Huzjan, A and Strineka, M and Basic, S and Demarin, V}, journal-iso = {ACTA CLIN CROAT}, journal = {ACTA CLINICA CROATICA}, volume = {48}, unique-id = {22457090}, issn = {0353-9466}, year = {2009}, eissn = {1333-9451}, pages = {299-304} } @article{MTMT:20768604, title = {Transcranial Doppler study of cerebrovascular reactivity: Are migraineurs more sensitive to breath-hold challenge?}, url = {https://m2.mtmt.hu/api/publication/20768604}, author = {Chan, S -t and Tam, Y and Lai, C -y and Wu, H -y and Lam, Y -k and Wong, P -n and Kwong, K K}, doi = {10.1016/j.brainres.2009.07.057}, journal-iso = {BRAIN RES}, journal = {BRAIN RESEARCH}, volume = {1291}, unique-id = {20768604}, issn = {0006-8993}, year = {2009}, eissn = {1872-6240}, pages = {53-59} } @article{MTMT:20774709, title = {Cerebrovascular reactivity, intima-media thickness, and nephropathy presence in patients with type 1 diabetes}, url = {https://m2.mtmt.hu/api/publication/20774709}, author = {Kozera, G M and Wolnik, B and Kunicka, K B and Szczyrba, S and Wojczal, J and Schminke, U and Nyka, W M and Bieniaszewski, L}, doi = {10.2337/dc08-1805}, journal-iso = {DIABETES CARE}, journal = {DIABETES CARE}, volume = {32}, unique-id = {20774709}, issn = {0149-5992}, year = {2009}, eissn = {1935-5548}, pages = {878-882} } @article{MTMT:2405933, title = {Carotid intima-media thickness and cerebrovascular reactivity in long-term type 1 diabetes mellitus}, url = {https://m2.mtmt.hu/api/publication/2405933}, author = {Siró, Péter and Molnár, Csilla and Katona, E and Antek, C and Kollár, J and Settakis, G and Fülesdi, Béla}, doi = {10.1002/jcu.20617}, journal-iso = {J CLIN ULTRASOUND}, journal = {JOURNAL OF CLINICAL ULTRASOUND}, volume = {37}, unique-id = {2405933}, issn = {0091-2751}, year = {2009}, eissn = {1097-0096}, pages = {451-456} } @article{MTMT:30879827, title = {The changes of - cerebrovascular responsiveness in patients with transitory ischemic attacks in the carotid region}, url = {https://m2.mtmt.hu/api/publication/30879827}, author = {Белявский, Н.Н. and Лихачев, С.А. and Belyavsky, N.N. and Likhachev, S. A}, journal-iso = {NEVROL ZH}, journal = {NEVROLOGICHESKII ZHURNAL}, volume = {13}, unique-id = {30879827}, issn = {1560-9545}, abstract = {С целью объективизации изменений цереброваскулярной реактивности (ЦБР) проведено комплексное обследование 40 больных в возрасте 43-67 лет с транзиторными ишемическими атаками (ТИА) в каротидном бассейне (КБ). Контрольная группа включала 25 практически здоровых добровольцев сопоставимого возраста. Для исследования ЦБР использованы проба с произвольной задержкой дыхания и вычислением индекса задержки дыхания и тест с гипервентиляцией и задержкой дыхания. У больных с ТИА в КБ выявлены различные по степени выраженности и продолжительности изменения ЦБР, находящиеся в определенной зависимости от ведущего патогенетического механизма заболевания. У больных с ТИА в КБ на фоне изолированной артериальной гипертензии выявлены два основных варианта динамики изменений ЦБР. У 58,3% пациентов более выраженным изменениям ЦБР соответствовало более тяжелое течение заболевания, характеризующееся большей длительностью приступов дисгемии и степенью выраженности явлений церебральной микроангиопатии. У больных с ТИА на фоне гемодинамически значимого поражения церебральных артерий наиболее выраженное снижение резервов регуляции сосудистого тонуса при отсутствии достоверной положительной динамики в процессе лечения наблюдалось на стороне пораженного артериального бассейна. У 37,5% больных с кардиоэмболическим генозом ТИА в особенности на 2-4-й день после перенесенной атаки выявлены выраженные нарушения ЦБР, ассоциировавшиеся с более тяжелым течением, а иногда с неблагоприятным исходом заболевания.The article reviews the results of a complex investigation aimed at the objectivization of the changes of cerebrovascular responsiveness (CVR). Forty (40) patients aged 43 - 67years old with transitory ischemic attacks \(TIA) in the carotid region (CR) were enrolled in the study. The control group comprised 25 age-matched healthy volunteers. For the assessment of CVR the test with voluntary breath-holding and calculation of breath-holding index was carried out. Bеsides, the test with hyperventilation and breath-holding was performed. In patients with TIA in CR the changes of CVR characterized by different degrees and duration were detected. Such changes depended on the principal patho-genetic mechanism. In subjects with TIA in CR associated with isolated arterial hypertension two main types of the time-course changes of CVR were detected. In 58.3% of the patients more prominent changes correlated with more severe course of the disease characterized by more prolonged attacks ofdyshemia and more intense neuroimaging signs of cerebral microangiopathy. In subjects with TIA associated with hemodynamically significant cerebral arterial lesions the most prominent decrease of CVR was detected on the side of the affected arterial region that was associated with the lack of significant positive therapeutic effect. In 37.5% patients with TIA of cardioembolic origin especially on the 2 - 4th day since the attack marked pathological changes of CVR were revealed. Such changes were associated with more severe course of the disease and in some cases with unfavorable outcome.}, keywords = {Cerebrovascular responsiveness; цереброваскулярная реактивность; транзиторные ишемические атаки; каротидный бассейн; transitory ischemic attack; carotid region}, year = {2008}, eissn = {2413-0699}, pages = {21-25} } @{MTMT:32591696, title = {Risk stratification of patients with asymptomatic carotid artery stenosis: Evaluation of cerebrovascular reserve}, url = {https://m2.mtmt.hu/api/publication/32591696}, author = {Frontera, J.A. and Marshall, R.}, booktitle = {Asymptomatic Carotid Artery Stenosis: A Primer on Risk Stratification and Management}, unique-id = {32591696}, abstract = {CVR refers to the capacity of the brain to increase cerebral blood volume (CBV) to maintain a constant CBF in the face of low cerebral perfusion pressure (CPP). Regional cerebral blood flow is determined by the ratio of CPP to cerebrovascular resistance by the formula:CBF CPP/vascular resistanceCerebral perfusion pressure is related to systemic MAP and intracranial pressure (ICP) by the equation:CPP MAP - ICPIn healthy individuals, a constant CBF is maintained over a wide range of CPP, with mean CBF values approximately 50 ml/100 g/min (Figure 10.1). When CBF values fall below 20 ml/100 g/min, ischemia ensues. Infarction occurs at CBF levels 10-15 ml/100 g/min. © 2007 by Taylor & Francis Group, LLC.}, year = {2007}, pages = {129-139} } @article{MTMT:20314391, title = {Application of hyperventilation index for assessing cerebrovascular reactivity}, url = {https://m2.mtmt.hu/api/publication/20314391}, author = {Ma, X and Hua, Y and Ling, C}, journal-iso = {ZHONGGUO NAO XUE GUAN BING ZA ZH}, journal = {ZHONGGUO NAO XUE GUAN BING ZA ZHI / CHINESE JOURNAL OF CEREBROVASCULAR DISEASE}, volume = {4}, unique-id = {20314391}, issn = {1672-5921}, year = {2007}, pages = {505-508} } @article{MTMT:20314390, title = {Holotropic breathwork: The potential role of a prolonged, voluntary hyperventilation procedure as an adjunct to psychotherapy}, url = {https://m2.mtmt.hu/api/publication/20314390}, author = {Rhinewine, J P and Williams, O J}, doi = {10.1089/acm.2006.6203}, journal-iso = {J ALTERN COMPLEM MED}, journal = {JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE}, volume = {13}, unique-id = {20314390}, issn = {1075-5535}, year = {2007}, eissn = {1557-7708}, pages = {771-776} } @article{MTMT:20145769, title = {Cerebrovascular dynamics in patients with migraine: Near-infrared spectroscopy study}, url = {https://m2.mtmt.hu/api/publication/20145769}, author = {Akin, A and Bilensoy, D and Emir, U E and Gulsoy, M and Candansayar, S and Bolay, H}, doi = {10.1016/j.neulet.2006.02.016}, journal-iso = {NEUROSCI LETT}, journal = {NEUROSCIENCE LETTERS}, volume = {400}, unique-id = {20145769}, issn = {0304-3940}, year = {2006}, eissn = {1872-7972}, pages = {86-91} } @article{MTMT:1100507, title = {Both Nitric Oxide And Endothelin-1 Influence Cerebral Blood Flow Velocity at Rest And After Hyper- And Hypocapnic Stimuli in Hypertensive And Healthy Adolescents}, url = {https://m2.mtmt.hu/api/publication/1100507}, author = {Katona, E and Settakis, G and Varga, Z and Juhasz, M and Paragh, György and Bereczki, Dániel and Fülesdi, Béla and Páll, Dénes}, doi = {10.1156/000095348}, journal-iso = {KIDNEY BLOOD PRESS R}, journal = {KIDNEY AND BLOOD PRESSURE RESEARCH}, volume = {29}, unique-id = {1100507}, issn = {1420-4096}, abstract = {Background and Purpose: Nitric oxide (NO)/endothelin imbalance may play a role in the regulation of cerebral blood flow. The aim of the present study was to assess whether these endothelial factors influence middle cerebral artery blood flow velocities (MCAV) and cerebrovascular reactivity (CVR) in healthy and hypertensive adolescents. Subjects and Methods: 106 adolescents (61 hypertensive and 45 normotensive) underwent transcranial Doppler measurements of the middle cerebral artery at rest and after 30 s of breath-holding (BH) and 60 s of hyperventilation (HV). Additionally, NO and endothelin-1 (ET-1) concentrations of the serum were assessed. The correlation between NO and ET-1 levels as well as MCAV and CVR values was analyzed. Results: Resting MCAVs were higher among hypertensive teenagers (76.5 +/- 24 vs. 62.8 +/- 15.6 cm/s, respectively, p < 0.001). CVR values did not differ between hypertensive and healthy adolescents after the BH and HV procedure. A significant negative correlation was found between absolute MCAV values and NO concentrations. ET-1 was positively related to MCAV. Conclusions: Cerebral blood flow velocities, but not CVR values, are associated with serum NO and ET-1 concentrations in adolescents. Copyright (c) 2006 S. Karger AG, Basel.}, year = {2006}, eissn = {1423-0143}, pages = {152-158}, orcid-numbers = {Bereczki, Dániel/0000-0002-8374-0500} } @article{MTMT:22457287, title = {Cerebrovascular reactivity over time course in healthy subjects}, url = {https://m2.mtmt.hu/api/publication/22457287}, author = {Schwertfeger, N and Neu, P and Schlattmann, P and Lemke, H and Heuser, I and Bajbouj, M}, doi = {10.1016/j.jns.2006.06.009}, journal-iso = {J NEUROL SCI}, journal = {JOURNAL OF THE NEUROLOGICAL SCIENCES}, volume = {249}, unique-id = {22457287}, issn = {0022-510X}, year = {2006}, eissn = {1878-5883}, pages = {135-139} } @inproceedings{MTMT:23142272, title = {Inspection of separability of normal and migraine fNIRS data using LDA and PCA}, url = {https://m2.mtmt.hu/api/publication/23142272}, author = {Sen, I and Akin, A}, booktitle = {2006 IEEE 14th Signal Processing and Communications Applications, Vols 1 and 2}, doi = {10.1109/SIU.2006.1659789}, publisher = {IEEE}, unique-id = {23142272}, year = {2006}, pages = {643-646} } @article{MTMT:1100513, title = {Hyperventilation-induced Cerebrovascular Reactivity Among Hypertensive And Healthy Adolescents}, url = {https://m2.mtmt.hu/api/publication/1100513}, author = {Settakis, G and Páll, Dénes and Molnár, Csilla and Katona, E and Bereczki, Dániel and Fülesdi, Béla}, doi = {10.1159/000097018}, journal-iso = {KIDNEY BLOOD PRESS R}, journal = {KIDNEY AND BLOOD PRESSURE RESEARCH}, volume = {29}, unique-id = {1100513}, issn = {1420-4096}, abstract = {Background: It is known that cerebral vasoreactivity is altered in adult arterial hypertension but no information is available about cerebral arteriolar function in hypertensive adolescents. Therefore, the aim of the present work was to assess cerebral vasoreactivity responses in adolescent hypertension. Methods: 113 hypertensive and 58 normotensive adolescents were assessed with transcranial Doppler sonography by using voluntary hyperventilation (HV) as vasoconstrictory stimulus. Absolute blood flow velocities (systolic, mean and diastolic) and pulsatility indices (PIs) at rest and after HV, as well as percentage change of the blood flow velocities after HV were compared among the groups. Results: Blood flow velocities at rest were significantly higher in hypertensive individuals, while PIs were similar in the two groups. After HV, all blood flow velocity parameters were higher among hypertensive teenagers than in healthy controls, while PIs did not differ between the two groups. Taking the relative changes after HV into account, it was found that HV induced a more pronounced change of the systolic and mean blood flow velocities of the control subjects than in hypertensive adolescents. Conclusions: Cerebrovascular reactivity to hypocapnia is decreased in hypertensive adolescents as compared to healthy teenagers. Further studies are needed to clarify the clinical significance of altered cerebral microvascular function in adolescent hypertension. Copyright (c) 2006 S. Karger AG,}, year = {2006}, eissn = {1423-0143}, pages = {306-311}, orcid-numbers = {Bereczki, Dániel/0000-0002-8374-0500} } @article{MTMT:20314385, title = {The impact of carotid stenting on the hemodynamic parameters and cerebrovascular reactivity of the ipsilateral middle cerebral artery}, url = {https://m2.mtmt.hu/api/publication/20314385}, author = {Sfyroeras, G and Karkos, C D and Liasidis, C and Spyridis, C and Dimitriadis, A S and Kouskouras, K and Gerassimidis, T S}, doi = {10.1016/j.jvs.2006.07.025}, journal-iso = {J VASC SURG}, journal = {JOURNAL OF VASCULAR SURGERY}, volume = {44}, unique-id = {20314385}, issn = {0741-5214}, year = {2006}, eissn = {1097-6809}, pages = {1016-1022} } @article{MTMT:20314389, title = {Clinical assessment of three cerebrovascular reactivity methods}, url = {https://m2.mtmt.hu/api/publication/20314389}, author = {Wang, J -F and Wang, D -X and Gao, F -L and Xu, Z -B}, journal-iso = {CHIN J CONTEMP NEUROLNEUROSURG}, journal = {ZHONGGUO XIANDAI SHENJING JIBING ZAZHI / CHINESE JOURNAL OF CONTEMPORARY NEUROLOGY AND NEUROSURGERY}, volume = {6}, unique-id = {20314389}, issn = {1672-6731}, year = {2006}, pages = {459-462} } @inproceedings{MTMT:23138459, title = {fNIRS Measurements in migraine}, url = {https://m2.mtmt.hu/api/publication/23138459}, author = {Akin, A and Emir, UE and Bilensoy, D and Erdogan, G and Candansyar, S and Bolay, H}, booktitle = {Optical Tomography and Spectroscopy of Tissue VI}, doi = {10.1117/12.590594}, unique-id = {23138459}, year = {2005}, pages = {417-423} } @article{MTMT:1005547, title = {Correlation between blood flow velocity in the middle cerebral artery and EEG during cognitive effort}, url = {https://m2.mtmt.hu/api/publication/1005547}, author = {Szirmai, Imre and Amrein, I and Palvolgyi, L and Debreczeni, Róbert and Kamondi, Anita}, doi = {10.1016/j.cogbrainres.2004.12.011}, journal-iso = {COGNITIVE BRAIN RES}, journal = {COGNITIVE BRAIN RESEARCH}, volume = {24}, unique-id = {1005547}, issn = {0926-6410}, abstract = {Cognitive effort modifies blood flow velocity (BFV) in the middle cerebral artery (MCA) which can be recorded by transcranial Doppler sonography (TCD). EEG parameters can be used as indicators of cortical activation. To find temporal and spatial relation between circulatory and bioelectric phenomena, we used combined EEG and TCD measurements during cognitive experiments. Bilateral BFV in the MCAs and 16-channel scalp EEG were recorded during mental arithmetic (MA) and verbal fluency (VF) tests in 12 healthy volunteers. Temporal profile of BFV, heart rate (HR), EEG central frequency (CF), relative alpha power (ralphap), and laterality index (Li) for BFV and CF were statistically analysed. During mental effort, BFV changes showed a reproducible pattern, which was different in MA and VF tests. The Li(BFV) correlated with handedness in 9/12 subjects (75%) in the VF, and in 6/12 subjects (50%) in the MA test. Significant correlation was found between Li(BFV) and Li(CF) during VF (r(2) = 0.69). Li was more indicative for the hemispheric dominance in the VF than in the MA test. During VF test, correlation between HR and BFV was significant in 7/12 subjects. CF and ralphap provide real time assessment of the functional state of the brain tissue during cognition. The correlation between CF and BFV during mental activity suggests a short latency neurogenic and a long latency, supposedly chemical regulation of regional blood flow. Parallel analysis of EEG and flow parameters increases the confidence of determining hemispheric dominance and provides an alternative to study physiological consequences of cognitive processes.}, year = {2005}, pages = {33-40}, orcid-numbers = {Debreczeni, Róbert/0000-0001-5115-2125; Kamondi, Anita/0000-0001-9860-730X} } @article{MTMT:24167505, title = {Assessment: Transcranial Doppler ultrasonography - Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology}, url = {https://m2.mtmt.hu/api/publication/24167505}, author = {Sloan, MA and Alexandrov, AV and Tegeler, CH and Spencer, MP and Caplan, LR and Feldmann, E and Wechsler, LR and Newell, DW and Gomez, CR and Babikian, VL and Lefkowitz, D and Goldman, RS and Armon, C and Hsu, CY and Goodin, DS}, doi = {10.1212/WNL.62.9.1468}, journal-iso = {NEUROLOGY}, journal = {NEUROLOGY}, volume = {62}, unique-id = {24167505}, issn = {0028-3878}, abstract = {Objective: To review the use of transcranial Doppler ultrasonography (TCD) and transcranial color-coded sonography (TCCS) for diagnosis. Methods: The authors searched the literature for evidence of 1) if TCD provides useful information in specific clinical settings; 2) if using this information improves clinical decision making, as reflected by improved patient outcomes; and 3) if TCD is preferable to other diagnostic tests in these clinical situations. Results: TCD is of established value in the screening of children aged 2 to 16 years with sickle cell disease for stroke risk (Type A, Class I) and the detection and monitoring of angiographic vasospasm after spontaneous subarachnoid hemorrhage (Type A, Class I to II). TCD and TCCS provide important information and may have value for detection of intracranial steno-occlusive disease (Type B, Class II to III), vasomotor reactivity testing (Type B, Class II to III), detection of cerebral circulatory arrest/brain death (Type A, Class II), monitoring carotid endarterectomy (Type B, Class II to III), monitoring cerebral thrombolysis (Type B, Class II to III), and monitoring coronary artery bypass graft operations (Type B to C, Class II to III). Contrast-enhanced TCD/TCCS can also provide useful information in right-to-left cardiac/extracardiac shunts (Type A, Class II), intracranial occlusive disease (Type B, Class II to IV), and hemorrhagic cerebrovascular disease (Type B, Class II to IV), although other techniques may be preferable in these settings.}, year = {2004}, eissn = {1526-632X}, pages = {1468-1481} } @article{MTMT:1052888, title = {Acetazolamide as a vasodilatory stimulus in cerebrovascular diseases and in conditions affecting the cerebral vasculature}, url = {https://m2.mtmt.hu/api/publication/1052888}, author = {Settakis, G and Molnár, Csilla and Kerenyi, L and Kollár, József and Legemate, D and Csiba, László and Fülesdi, Béla}, doi = {10.1046/j.1468-1331.2003.00675.x}, journal-iso = {EUR J NEUROL}, journal = {EUROPEAN JOURNAL OF NEUROLOGY}, volume = {10}, unique-id = {1052888}, issn = {1351-5101}, abstract = {Pathologic processes affecting the brain vessels may damage cerebral vasodilatory capacity. Early detection of cerebral dysfunction plays an important role in the prevention of cerebrovascular diseases. In recent decades acetazolamide (AZ) has frequently been used for this purpose. In the present work the mechanism of action and the previous studies are reviewed. The authors conclude that AZ tests are useful in cerebrovascular research. Further investigations are recommended to prove how impaired reserve capacity and reactivity influence the stroke risk in patients and whether these tests may indicate therapeutic interventions.}, year = {2003}, eissn = {1468-1331}, pages = {609-620} } @article{MTMT:1052876, title = {Cerebrovascular reactivity in hypertensive and healthy adolescents: TCD with vasodilatory challenge}, url = {https://m2.mtmt.hu/api/publication/1052876}, author = {Settakis, G and Páll, Dénes and Molnár, Csilla and Bereczki, Dániel and Csiba, László and Fülesdi, Béla}, doi = {10.1177/1051228403251265}, journal-iso = {J NEUROIMAGING}, journal = {JOURNAL OF NEUROIMAGING}, volume = {13}, unique-id = {1052876}, issn = {1051-2284}, abstract = {BACKGROUND: Adolescent hypertension predicts hypertension and increased cardiovascular morbidity in adulthood. The aim of the present work was to test whether cerebrovascular reactivity to CO2 is altered among hypertensive adolescents. METHODS: From the population-based cohort of the Debrecen Hypertension Study, 113 hypertensive and 58 normotensive adolescents underwent transcranial Doppler measurements at rest and after 30 seconds of breath holding. RESULTS: Systolic, mean, and diastolic blood flow velocities were higher among hypertensive individuals at rest. Taking the absolute blood flow velocity parameters into account, after breath holding, only the pulsatility index was significantly higher in the hypertensive group. The percentage change of the different blood flow parameters showed less intensive change in hypertensive teenagers. CONCLUSION: Cerebral vasoreactivity is decreased among hypertensive individuals as compared to healthy controls.}, year = {2003}, eissn = {1552-6569}, pages = {106-112}, orcid-numbers = {Bereczki, Dániel/0000-0002-8374-0500} }