TY - JOUR AU - Sipido, Karin R. AU - Eisner, David A. TI - Edward Carmeliet: his contributions and scientific legacy JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 599 PY - 2021 IS - 21 SP - 4727 EP - 4729 PG - 3 SN - 0022-3751 DO - 10.1113/JP282357 UR - https://m2.mtmt.hu/api/publication/32463867 ID - 32463867 LA - English DB - MTMT ER - TY - JOUR AU - Varró, András AU - Tomek, Jakub AU - Nagy, Norbert AU - Virág, László AU - Passini, Elisa AU - Rodriguez, Blanca AU - Baczkó, István TI - Cardiac Transmembrane Ion Channels and Action Potentials: Cellular Physiology and Arrhythmogenic Behavior JF - PHYSIOLOGICAL REVIEWS J2 - PHYSIOL REV VL - 101 PY - 2021 IS - 3 SP - 1083 EP - 1176 PG - 94 SN - 0031-9333 DO - 10.1152/physrev.00024.2019 UR - https://m2.mtmt.hu/api/publication/32106256 ID - 32106256 N1 - Funding Agency and Grant Number: National Research, Development and Innovation OfficeNational Research, Development & Innovation Office (NRDIO) - Hungary [NKFIH-K-119992, GINOP-2.3.2-15-2016-00006, NKFIH-K-128851, PD-125402, FK-129117]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences; Hungarian Academy of SciencesHungarian Academy of Sciences; Wellcome Trust Fellowship in Basic Biomedical SciencesWellcome Trust [214290/Z/18/Z]; NC3Rs Infrastructure for Impact Award [NC/P001076/1] Funding text: This work was supported by the National Research, Development and Innovation Office [NKFIH-K-119992, and GINOP-2.3.2-15-2016-00006 (MOLMEDEX) to A.V., NKFIH-K-128851 to I.B., PD-125402, FK-129117 to N.N.], the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences to N.N., and the Hungarian Academy of Sciences, as well as a Wellcome Trust Fellowship in Basic Biomedical Sciences (214290/Z/18/Z) and an NC3Rs Infrastructure for Impact Award (NC/P001076/1) to B.R. Funding Agency and Grant Number: National Research, Development and Innovation OfficeNational Research, Development & Innovation Office (NRDIO) - Hungary [NKFIH-K-119992, GINOP-2.3.2-15-2016-00006, NKFIH-K-128851, PD-125402, FK-129117]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences; Hungarian Academy of SciencesHungarian Academy of Sciences; Wellcome Trust Fellowship in Basic Biomedical SciencesWellcome Trust [214290/Z/18/Z]; NC3Rs Infrastructure for Impact AwardUK Research & Innovation (UKRI)National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs) [NC/P001076/1] Funding text: This work was supported by the National Research, Development and Innovation Office [NKFIH-K-119992, and GINOP-2.3.2-15-2016-00006 (MOLMEDEX) to A.V., NKFIH-K-128851 to I.B., PD-125402, FK-129117 to N.N.], the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences to N.N., and the Hungarian Academy of Sciences, as well as a Wellcome Trust Fellowship in Basic Biomedical Sciences (214290/Z/18/Z) and an NC3Rs Infrastructure for Impact Award (NC/P001076/1) to B.R. AB - Cardiac arrhythmias are among the leading causes of mortality. They often arise from alterations in the electro-physiological properties of cardiac cells and their underlying ionic mechanisms. It is therefore critical to further unravel the pathophysiology of the ionic basis of human cardiac electrophysiology in health and disease. In the first part of this review, current knowledge on the differences in ion channel expression and properties of the ionic processes that determine the morphology and properties of cardiac action potentials and calcium dynamics from cardiomyocytes in different regions of the heart are described. Then the cellular mechanisms promoting arrhythmias in congenital or acquired conditions of ion channel function (electrical remodeling) are discussed. The focus is on human-relevant findings obtained with clinical, experimental, and computational studies, given that interspecies differences make the extrapolation from animal experiments to human clinical settings difficult. Deepening the understanding of the diverse pathophysiology of human cellular electrophysiology will help in developing novel and effective antiarrhythmic strategies for specific subpopulations and disease conditions. LA - English DB - MTMT ER - TY - JOUR AU - Matchkov, Vladimir V. AU - Boedtkjer, Donna M. AU - Aalkjaer, Christian TI - The role of Ca2+ activated Cl- channels in blood pressure control JF - CURRENT OPINION IN PHARMACOLOGY J2 - CURR OPIN PHARMACOL VL - 21 PY - 2015 SP - 127 EP - 137 PG - 11 SN - 1471-4892 DO - 10.1016/j.coph.2015.02.003 UR - https://m2.mtmt.hu/api/publication/32076870 ID - 32076870 N1 - Funding Agency and Grant Number: Danish Research CouncilDet Frie Forskningsrad (DFF); Lundbeck FoundationLundbeckfonden; Danish Heart Foundation; Novo Nordisk FoundationNovo Nordisk Foundation Funding text: The work was supported by the Danish Research Council, the Lundbeck Foundation, the Danish Heart Foundation and the Novo Nordisk Foundation. AB - Ca2+-activated Cl- channels (CaCCs) have numerous functions in the body and are potential players in the control of blood pressure. The CaCCs represent a heterologous group including at least two protein families; TMEM16 and bestrophins. CaCCs expression has been shown in the kidney, the heart and blood vessels. Agonist-stimulated Ca2+-activated Cl- current is important for secretion in kidney epithelia, generation of a repolarizing current in the heart and amplification of excitation-contraction coupling in vascular smooth muscle cells. Changes in CaCC expression are shown in association with hypertension, kidney cysts, sudden cardiac death and arrhythmias. This review discusses recent advances in studies concerning the role of CaCC for blood pressure control with focus on the kidney, the heart and blood vessels. LA - English DB - MTMT ER - TY - JOUR AU - Lin, Yung-Kuo AU - Chen, Yao-Chang AU - Kao, Yu-Hsun AU - Tsai, Chin-Feng AU - Yeh, Yung-Hsin AU - Huang, Jin-Long AU - Cheng, Chen-Chuan AU - Chen, Shih-Ann AU - Chen, Yi-Jen TI - A monounsaturated fatty acid (oleic acid) modulates electrical activity in atrial myocytes with calcium and sodium dysregulation JF - INTERNATIONAL JOURNAL OF CARDIOLOGY J2 - INT J CARDIOL VL - 176 PY - 2014 IS - 1 SP - 191 EP - 198 PG - 8 SN - 0167-5273 UR - https://m2.mtmt.hu/api/publication/24522881 ID - 24522881 LA - English DB - MTMT ER - TY - JOUR AU - Boyden, PA AU - Hirose, M AU - Dun, W TI - Cardiac Purkinje cells JF - HEART RHYTHM J2 - HEART RHYTHM VL - 7 PY - 2010 IS - 1 SP - 127 EP - 135 PG - 9 SN - 1547-5271 DO - 10.1016/j.hrthm.2009.09.017 UR - https://m2.mtmt.hu/api/publication/20969441 ID - 20969441 N1 - Megjegyzés-20906367 Chemicals/CAS: calsequestrin, 110735-04-1; protein, 67254-75-5 UR: http://www.scopus.com/inward/record.url?eid=2-s2.0-72449124113&partnerID=40&md5=39d155ee8f84dae29925b163e31c8d66 LA - English DB - MTMT ER - TY - JOUR AU - Dumaine, R AU - Cordeiro, JM TI - Comparison of K+ currents in cardiac Purkinje cells isolated from rabbit and dog JF - JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY J2 - J MOL CELL CARDIOL VL - 42 PY - 2007 IS - 2 SP - 378 EP - 389 PG - 12 SN - 0022-2828 DO - 10.1016/j.yjmcc.2006.10.019 UR - https://m2.mtmt.hu/api/publication/20294196 ID - 20294196 LA - English DB - MTMT ER - TY - BOOK AU - O'Driscoll, Kate E TI - Molecular and functional expression of the murine Bestrophin family from cardiovascular tissues PB - ProQuest PY - 2007 UR - https://m2.mtmt.hu/api/publication/24522882 ID - 24522882 LA - English DB - MTMT ER - TY - JOUR AU - Ter, Keurs Henk E D J AU - Boyden, Penelope A TI - Calcium and arrhythmogenesis JF - PHYSIOLOGICAL REVIEWS J2 - PHYSIOL REV VL - 87 PY - 2007 IS - 2 SP - 457 EP - 506 PG - 50 SN - 0031-9333 DO - 10.1152/physrev.00011.2006 UR - https://m2.mtmt.hu/api/publication/25685316 ID - 25685316 LA - English DB - MTMT ER - TY - JOUR AU - Boyden, PA AU - ter Keurs, H TI - Would modulation of intracellular Ca(2+) be antiarrhythmic? JF - PHARMACOLOGY & THERAPEUTICS J2 - PHARMACOL THERAPEUT VL - 108 PY - 2005 IS - 2 SP - 149 EP - 179 PG - 31 SN - 0163-7258 DO - 10.1016/j.pharmthera.2005.03.011 UR - https://m2.mtmt.hu/api/publication/25685325 ID - 25685325 LA - English DB - MTMT ER - TY - JOUR AU - Hartzell, C AU - Putzier, I AU - Arreola, J TI - Calcium-activated chloride channels JF - ANNUAL REVIEW OF PHYSIOLOGY J2 - ANNU REV PHYSIOL VL - 67 PY - 2005 SP - 719 EP - 758 PG - 40 SN - 0066-4278 DO - 10.1146/annurev.physiol.67.032003.154341 UR - https://m2.mtmt.hu/api/publication/20952421 ID - 20952421 N1 - Megjegyzés-21130551 Calcium-activated chloride channels AN: ISI:000228406800030 PM: PMCID ID: 22 LA - English DB - MTMT ER - TY - JOUR AU - Édes, I TI - Pozitív inotropia farmakológiai Ca2+-érzékenyítés árán: preklinikai és klinikai tapasztalatok Ca2+-érzékenyítőkkel JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 34 PY - 2004 SP - E52 EP - E56 SN - 0133-5596 UR - https://m2.mtmt.hu/api/publication/20011868 ID - 20011868 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Shannon, TR AU - Bers, DM TI - Integrated Ca2+ management in cardiac myocytes VL - 1015 PY - 2004 SP - 28 EP - 38 PG - 11 UR - https://m2.mtmt.hu/api/publication/20432896 ID - 20432896 LA - English DB - MTMT ER - TY - JOUR AU - Marban, Eduardo TI - Cardiac Channelopathies JF - HEART VIEWS J2 - HEART VIEW VL - 4 PY - 2003 IS - 3 SP - 4 SN - 1995-705X UR - https://m2.mtmt.hu/api/publication/24522884 ID - 24522884 LA - English DB - MTMT ER - TY - JOUR AU - Stankovicova, T AU - Bito, V AU - Heinzel, F AU - Mubagwa, K AU - Sipido, K R TI - Isolation and morphology of single Purkinje cells from the porcine heart JF - GENERAL PHYSIOLOGY AND BIOPHYSICS J2 - GEN PHYSIOL BIOPHYS VL - 22 PY - 2003 SP - 329 EP - 340 PG - 12 SN - 0231-5882 UR - https://m2.mtmt.hu/api/publication/20011515 ID - 20011515 LA - English DB - MTMT ER - TY - JOUR AU - Machaca, K AU - Qu, Z Q AU - Kuruma, A AU - Hartzell, H C AU - McCarty, N TI - The endogenous calcium-activated Cl channel in Xenopus oocytes: A physiologically and biophysically rich model system JF - CURRENT TOPICS IN MEMBRANES J2 - CURR TOP MEMBR VL - 53 PY - 2002 SP - 3 EP - 39 PG - 37 SN - 1063-5823 UR - https://m2.mtmt.hu/api/publication/21130563 ID - 21130563 N1 - The endogenous calcium-activated Cl channel in Xenopus oocytes: A physiologically and biophysically rich model system AN: ISI:000178445000001 ID: 33 LA - English DB - MTMT ER - TY - JOUR AU - Marban, E TI - Cardiac channelopathies JF - NATURE J2 - NATURE VL - 415 PY - 2002 IS - 6868 SP - 213 EP - 218 PG - 6 SN - 0028-0836 DO - 10.1038/415213a UR - https://m2.mtmt.hu/api/publication/24274799 ID - 24274799 LA - English DB - MTMT ER - TY - JOUR AU - Nakajima, I AU - Watanabe, H AU - Iino, K AU - Saito, T AU - Miura, M TI - Ca2+ overload evokes a transient outward current in guinea-pig ventricular myocytes JF - CIRCULATION JOURNAL: OFFICIAL JOURNAL OF THE JAPANESE CIRCULATION SOCIETY J2 - CIRC J VL - 66 PY - 2002 IS - 1 SP - 87 EP - 92 PG - 6 SN - 1346-9843 DO - 10.1253/circj.66.87 UR - https://m2.mtmt.hu/api/publication/20434199 ID - 20434199 N1 - Cited By :11 Export Date: 4 October 2019 CODEN: CJIOB Correspondence Address: Saito, T.; Second Dept. of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondoh, Akita 010-8543, Japan Chemicals/CAS: 4-Aminopyridine, 504-24-5; Potassium Channels LA - English DB - MTMT ER - TY - CHAP AU - Trafford, A. W. AU - Eisner, D. A. ED - Solaro, Ross John ED - Moss, Richard Lee TI - Excitation-Contraction Coupling in Cardiac Muscle T2 - Molecular Control Mechanisms in Striated Muscle Contraction PB - Kluwer Academic Publishers CY - Dordrecht CY - Boston (MA), Massachusetts CY - London SN - 9789048160693 T3 - Advances in Muscle Research, ISSN 1571-5663 ; 1.. PY - 2002 SP - 49 EP - 89 PG - 41 DO - 10.1007/978-94-015-9926-9_2 UR - https://m2.mtmt.hu/api/publication/31379400 ID - 31379400 AB - Excitation-contraction coupling concerns the processes linking electrical excitation of the surface membrane to contraction. As shown in Fig. 1 A, the action potential produces a systolic increase of calcium that then activates contraction. This chapter will focus on the control of calcium and will largely ignore the contractile protein mechanisms that follow the increase of Ca. These events are described in detail in other chapters. Equally, on grounds of space, we will largely ignore the whole field of pharmacological modulation of e-c coupling. The reader is directed to the following books for recent summaries of the broad field of cardiac electrophysiology and contraction (Bers, 2001;Zipes & Jalife, 2000;Sperelakis et al., 2001). An overview of cellular Ca handling is shown in Fig. 1A. LA - English DB - MTMT ER - TY - BOOK AU - Bers, DM TI - Excitation-contraction coupling and cardiac contractile force PB - Kluwer Academic Publishers CY - London CY - Dordrecht CY - Boston (MA), Massachusetts PY - 2001 SP - 427 UR - https://m2.mtmt.hu/api/publication/20011753 ID - 20011753 LA - English DB - MTMT ER - TY - JOUR AU - Cordeiro, J M AU - Bridge, J H B AU - Spitzer, K W TI - Early and delayed afterdepolarizations in rabbit heart Purkinje cells viewed by confocal microscopy JF - CELL CALCIUM J2 - CELL CALCIUM VL - 29 PY - 2001 SP - 289 EP - 297 PG - 9 SN - 0143-4160 UR - https://m2.mtmt.hu/api/publication/20011522 ID - 20011522 LA - English DB - MTMT ER - TY - JOUR AU - Cordeiro, J M AU - Spitzer, K W AU - Giles, W R AU - Ershler, P E AU - Cannell, M B AU - Bridge, J H B TI - Location of the initiation site of calcium transients and sparks in rabbit heart Purkinje cells JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 531 PY - 2001 SP - 301 EP - 314 PG - 14 SN - 0022-3751 UR - https://m2.mtmt.hu/api/publication/20011523 ID - 20011523 LA - English DB - MTMT ER - TY - JOUR AU - Diaz, M E AU - Trafford, A W AU - Eisner, D A TI - The role of intracellular Ca buffers in determining the shape of the systolic Ca transient in cardiac ventricular myocytes JF - PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY J2 - PFLUG ARCH EUR J PHY VL - 442 PY - 2001 SP - 96 EP - 100 PG - 5 SN - 0031-6768 UR - https://m2.mtmt.hu/api/publication/20011521 ID - 20011521 LA - English DB - MTMT ER - TY - JOUR AU - Qu, Z Q AU - Hartzell, H C TI - Functional geometry of the permeation pathway of Ca2+-activated Cl- channels inferred from analysis of voltage-dependent block JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM VL - 276 PY - 2001 SP - 18423 EP - 18429 PG - 7 SN - 0021-9258 UR - https://m2.mtmt.hu/api/publication/20011520 ID - 20011520 LA - English DB - MTMT ER - TY - JOUR AU - Verkerk, AO AU - Veldkamp, MW AU - Baartscheer, A AU - Schumacher, CA AU - Klopping, C AU - van Ginneken, ACG AU - Ravesloot, JH TI - Ionic mechanism of delayed afterdepolarizations in ventricular cells isolated from human end-stage failing hearts JF - CIRCULATION J2 - CIRCULATION VL - 104 PY - 2001 IS - 22 SP - 2728 EP - 2733 PG - 6 SN - 0009-7322 DO - 10.1161/hc4701.099577 UR - https://m2.mtmt.hu/api/publication/24274802 ID - 24274802 LA - English DB - MTMT ER - TY - JOUR AU - Boyden, P A AU - Pu, J L AU - Pinto, J AU - Ter, Keurs H E D J TI - Ca2+ transients and Ca2+ waves in Purkinje cells - Role in action potential initiation JF - CIRCULATION RESEARCH J2 - CIRC RES VL - 86 PY - 2000 SP - 448 EP - 455 PG - 8 SN - 0009-7330 UR - https://m2.mtmt.hu/api/publication/20011526 ID - 20011526 LA - English DB - MTMT ER - TY - JOUR AU - Hume, J R AU - Duan, D AU - Collier, M L AU - Yamazaki, J AU - Horowitz, B TI - Anion transport in heart JF - PHYSIOLOGICAL REVIEWS J2 - PHYSIOL REV VL - 80 PY - 2000 SP - 31 EP - 81 PG - 51 SN - 0031-9333 UR - https://m2.mtmt.hu/api/publication/20011527 ID - 20011527 LA - English DB - MTMT ER - TY - JOUR AU - Kuruma, A AU - Hartzell, H C TI - Bimodal control of a Ca2+-activated Cl- channel by different Ca2+ signals JF - JOURNAL OF GENERAL PHYSIOLOGY J2 - J GEN PHYSIOL VL - 115 PY - 2000 IS - 1 SP - 59 EP - 80 PG - 22 SN - 0022-1295 UR - https://m2.mtmt.hu/api/publication/21130587 ID - 21130587 N1 - Jan Bimodal control of a Ca2+-activated Cl- channel by different Ca2+ signals AN: ISI:000084698500007 PM: PMCID ID: 57 LA - English DB - MTMT ER - TY - CHAP AU - Papp, Zoltán AU - Édes, István ED - Édes, I TI - A szív- és simaizomsejtek ingerületi folyamatai és celluláris Ca2+ anyagcseréje T2 - A szív- és simaizom Ca2+-anyagcseréje: elmélet, klinikum PB - Golden Book Kiadó CY - Budapest SN - 9639275069 PY - 2000 SP - 17 EP - 89 PG - 73 UR - https://m2.mtmt.hu/api/publication/1009038 ID - 1009038 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Schlotthauer, K AU - Bers, D M TI - Sarcoplasmic reticulum Ca2+ release causes myocyte depolarization - Underlying mechanism and threshold for triggered action potentials JF - CIRCULATION RESEARCH J2 - CIRC RES VL - 87 PY - 2000 SP - 774 EP - 780 PG - 7 SN - 0009-7330 DO - 10.1161/01.RES.87.9.774 UR - https://m2.mtmt.hu/api/publication/20011565 ID - 20011565 N1 - Cited By :260 Export Date: 7 October 2021 CODEN: CIRUA Correspondence Address: Bers, D.M.; Department of Physiology, 2160 South First Ave, Maywood, IL 60153, United States; email: dbers@luc.edu LA - English DB - MTMT ER - TY - JOUR AU - Zygmunt, A C AU - Goodrow, R J AU - Antzelevitch, C TI - I-NaCa contributes to electrical heterogeneity within the canine ventricle JF - AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY J2 - AM J PHYSIOL HEART C VL - 278 PY - 2000 SP - H1671 EP - H1678 SN - 0363-6135 UR - https://m2.mtmt.hu/api/publication/20011525 ID - 20011525 LA - English DB - MTMT ER - TY - JOUR AU - Carmeliet, E TI - Cardiac ionic currents and acute ischemia: From channels to arrhythmias JF - PHYSIOLOGICAL REVIEWS J2 - PHYSIOL REV VL - 79 PY - 1999 IS - 3 SP - 917 EP - 1017 PG - 101 SN - 0031-9333 UR - https://m2.mtmt.hu/api/publication/26320836 ID - 26320836 LA - English DB - MTMT ER - TY - JOUR AU - Dumotier, BM AU - Adamantidis, MM AU - Puisieux, FL AU - Bastide, MM AU - Dupuis, BA TI - Repercussions of pharmacologic reduction in ionic currents on action potential configuration in rabbit Purkinje fibers: Are they indicative of proarrhythmic potential? JF - DRUG DEVELOPMENT RESEARCH J2 - DRUG DEVELOP RES VL - 47 PY - 1999 IS - 2 SP - 63 EP - 76 PG - 14 SN - 0272-4391 DO - 10.1002/(SICI)1098-2299(199906)47:2<63::AID-DDR2>3.0.CO;2-5 UR - https://m2.mtmt.hu/api/publication/24610709 ID - 24610709 N1 - Laboratoire de Pharmacologie, Faculte de Medecine Henri Warembourg, Pôle Recherche, Lille, France Laboratoire de Pharmacologie, Faculte de Medecine Henri Warembourg, Pôle Recherche, 1 place de Verdun, F59045 Lille Cedex, France Cited By :21 Export Date: 4 October 2019 CODEN: DDRED Correspondence Address: Adamantidis, M.M.; Laboratoire de Pharmacologie, Faculte de Medecine Henri Warembourg, Pole Recherche, 1 place de Verdun, F59045 Lille Cedex, France Chemicals/CAS: 4,4' diisothiocyanatostilbene 2,2' disulfonic acid, 53005-05-3; cadmium, 22537-48-0, 7440-43-9; dofetilide, 115256-11-6; indapamide, 26807-65-8; nifedipine, 21829-25-4; terikalant, 121277-96-1, 121277-97-2, 132338-79-5; verapamil, 152-11-4, 52-53-9 LA - English DB - MTMT ER - TY - JOUR AU - Koster, O F AU - Szigeti, Gyula Péter AU - Beuckelmann, D J TI - Characterization of a [Ca2+]-dependent current in human atrial and ventricular cardiomyocytes in the absence of Na+ and K+ JF - CARDIOVASCULAR RESEARCH J2 - CARDIOVASC RES VL - 41 PY - 1999 IS - 1 SP - 175 EP - 187 PG - 13 SN - 0008-6363 DO - 10.1016/S0008-6363(98)00202-8 UR - https://m2.mtmt.hu/api/publication/1117232 ID - 1117232 N1 - Cited By :50 Export Date: 7 October 2021 CODEN: CVREA Correspondence Address: Koster, O.F.; Department of Internal Medicine III, Joseph-Stelzmann-Strasse 9, 50924 Cologne, Germany AB - Objectives: In situations of [Ca2+](i) overload, arrhythmias are believed to be triggered by delayed after depolarizations, which are generated by a transient inward current I(TI). This study was designed to examine [Ca2+](i)-dependent membrane currents in the absence of the Na+/Ca2+-exchanger as possible contributors to I(TI) in human cardiac cells. Methods: The whole cell voltage clamp technique was used for electrophysiological measurements in human atrial and ventricular cardiomyocytes. [Ca2+](i)-measurements were performed using the fluorescent Ca2+-indicator fura-2. All solutions were Na+-free. Voltage-independent [Ca2+](i)-measurements were performed using applications. Results: In atrial myocytes, caffeine induced a transient membrane current in the absence of Na+ and K+. This current could be suppressed by internal EGTA (10 mM). Cl- did not contribute to this current. Experiments with different cations suggested non-selectivity for Cs+ and Li+, whereas N-methyl-D-glucamine appeared to be impermeable. Voltage ramps indicated a linear current-voltage relation in the range of +80 to -80 mV. Fluorescence measurements revealed a dissociation between the time courses of current and bulk [Ca2+](i)- signal. In ventricular cardiomyocytes, caffeine failed to induce transient currents in 54 cells from 22 different patients with or without terminal heart failure. Conclusions: In human atrial cardiomyocytes, a [Ca2+](i)- dependent nonspecific cation channel is expressed and may contribute to triggered arrhythmias in situations of [Ca2+](i)-overload. No evidence could be found for the existence of a [Ca2+](i)-dependent chloride current in atrial cells. In ventricular cells, neither a [Ca2+](i)-dependent nonspecific cation channel nor a [Ca-2+](i)-dependent chloride channel seems to be expressed. Possible delayed after depolarizations in human ventricular myocardium might therefore be carried by the Na+/Ca2+- exchanger alone. LA - English DB - MTMT ER - TY - JOUR AU - Papp, Zoltán AU - Peineau, N AU - Szigeti, Gyula Péter AU - Argibay, J AU - Kovács, László TI - Calcium-dependent modulation of the plateau phase of action potential in isolated ventricular cells of rabbit heart JF - ACTA PHYSIOLOGICA SCANDINAVICA J2 - ACTA PHYSIOL SCAND VL - 167 PY - 1999 IS - 2 SP - 119 EP - 129 PG - 11 SN - 0001-6772 DO - 10.1046/j.1365-201x.1999.00599.x UR - https://m2.mtmt.hu/api/publication/1005461 ID - 1005461 N1 - Department of Physiology, University Medical, School of Debrecen, Debrecen, Hungary Laboratoire Tie Physiologie Des Cellules Cardiaques et Vasctilaires, Faculté Des Sciences, CNRS UAIR 6542, Parc de Grandmont, Tours, France Laboratorium Voor Fysiologie, Vrije Universitat, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands Cited By :5 Export Date: 7 October 2021 CODEN: APSCA Correspondence Address: Papp, Z.; Laboratorium Voor Fysiologie, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands AB - [Ca2+](i)-dependent modulation of the action potential has been studied in Fura-2 dialysed ventricular myocytes of the rabbit using the whole-cell current-clamp method. Fifteen consecutive action potentials (AP(1)-AP(15)) and [Ca2+](i) transients were elicited at a frequency of 0.2 Hz. A single, brief application of caffeine (during AP(9)) first enhanced and thereafter attenuated the [Ca2+](i) transients accompanying AP(9) and AP(10)-AP(12), respectively. This approach provided direct comparison between time courses of action potentials: during the initial steady state (e.g. AP(8)) and when Ca2+ release from the sarcoplasmic reticulum was increased by caffeine (AP(9)) or decreased by depletion (AP(10)). The increase in [Ca2+](i) facilitated repolarization and decreased action potential duration. However, action potentials at reduced Ca2+ release (AP(10)) had longer duration than during steady state. The caffeine-induced changes in L-type Ca2+ current (I-Ca,I-L), during voltage-clamp conditions partially explained the effects of caffeine on action potentials. When I-Ca,I-L was blocked by 500 mu mol L-1 Cd2+ enhanced [Ca2+](i) transients revealed an extra current component which was outward at +10 mV and inward at the resting membrane potential (most probably the transient inward current). in the presence of Cd2+, however, AP(8) and AP(10) had identical time courses, suggesting that I-Ca,I-L alone was responsible for the lengthening of AP(10). Alterations in the transmembrane Na+ gradient resulted in changes of the steady stale action potential durations (AP(8)) consistently with the expected modulation of the Na+-Ca2+ exchange current. However, the contribution of this current to the [Ca2+](i)-dependent behaviour of action potential plateau could not be demonstrated. LA - English DB - MTMT ER - TY - BOOK AU - Postma, Alex Vincent TI - Genetic Aspects of Cardiac Arrhythmia Syndromes PY - 1999 UR - https://m2.mtmt.hu/api/publication/24522887 ID - 24522887 LA - English DB - MTMT ER - TY - JOUR AU - Sorota, S TI - Insights into the structure, distribution and function of the cardiac chloride channels JF - CARDIOVASCULAR RESEARCH J2 - CARDIOVASC RES VL - 42 PY - 1999 SP - 361 EP - 376 PG - 16 SN - 0008-6363 UR - https://m2.mtmt.hu/api/publication/20011533 ID - 20011533 LA - English DB - MTMT ER - TY - JOUR AU - Verkerk, A O AU - Veldkamp, M W AU - Abbate, F AU - Antoons, G AU - Bouman, L N AU - Ravesloot, J H AU - van Ginneken, A C G TI - Two types of action potential configuration in single cardiac Purkinje cells of sheep JF - AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY J2 - AM J PHYSIOL HEART C VL - 277 PY - 1999 SP - H1299 EP - H1310 SN - 0363-6135 UR - https://m2.mtmt.hu/api/publication/20011529 ID - 20011529 LA - English DB - MTMT ER - TY - JOUR AU - Cordeiro, J M AU - Spitzer, K W AU - Giles, W R TI - Repolarizing K+ currents in rabbit heart Purkinje cells JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 508 PY - 1998 SP - 811 EP - 823 PG - 13 SN - 0022-3751 UR - https://m2.mtmt.hu/api/publication/20011537 ID - 20011537 LA - English DB - MTMT ER - TY - JOUR AU - Hiraoka, M AU - Kawano, S AU - Hirano, Y AU - Furukawa, T TI - Role of cardiac chloride currents in changes in action potential characteristics and arrhythmias JF - CARDIOVASCULAR RESEARCH J2 - CARDIOVASC RES VL - 40 PY - 1998 SP - 23 EP - 33 PG - 11 SN - 0008-6363 UR - https://m2.mtmt.hu/api/publication/20011536 ID - 20011536 LA - English DB - MTMT ER - TY - JOUR AU - Szigeti, Gyula Péter AU - Rusznak, Z AU - Kovacs, L AU - Papp, Zoltán TI - Calcium-activated transient membrane currents are carried mainly by chloride ions in isolated atrial, ventricular and Purkinje cells of rabbit heart JF - EXPERIMENTAL PHYSIOLOGY J2 - EXP PHYSIOL VL - 83 PY - 1998 IS - 2 SP - 137 EP - 153 PG - 17 SN - 0958-0670 DO - 10.1113/expphysiol.1998.sp004097 UR - https://m2.mtmt.hu/api/publication/1005465 ID - 1005465 AB - Under physiological conditions, calcium-dependent ([Ca2+](i)-dependent) Cl- currents (I-Cl(Ca)) have been suggested to participate in the repolarizing processes. In this paper, the possible contribution of I-Cl(Ca) to transient inward currents and, hence to arrhythmias, has been studied in myocytes from the working myocardium and from the conductive system. Single atrial, ventricular and Purkinje cells, isolated enzymatically from rabbit heart, have been studied under whole-cell voltage-clamp and were internally perfused with the fluorescent Ca2+ indicator, fura-2 (100 mu M). Ca2+ release from the sarcoplasmic reticulum was either induced by external application of caffeine or occurred spontaneously in Ca2+-overloaded cells. Membrane currents accompanying Ca2+ transients showed linear current-voltage characteristics between -60 and +80 mV as evidenced from fast voltage ramps. When intra- and extracellular Cl- concentrations were kept symmetrical in the absence of the Na+-Ca2+ exchange mechanism, transient currents had a reversal potential close to 0 mV. Reduction of external Cl- concentration shifted this reversal potential towards the new Cl- equilibrium potential. Neither the time course of the transient currents nor the shift in their reversal potentials was significantly affected by the presence of Na+. Approximately 90 % of this current was blocked by the application of the Cl- channel blocker, anthracene-9-carboxylic acid (0.5 mM) at +80 mV. It is concluded, that [Ca2+](i)-activated transient membrane currents in atrial, ventricular and Purkinje cells of rabbit heart are mainly due to the activation of a [Ca2+](i)- dependent Cl- current. LA - English DB - MTMT ER - TY - JOUR AU - Zygmunt, A C AU - Goodrow, R J AU - Weigel, C M TI - I-NaCa and I-Cl(Ca) contribute to isoproterenol-induced delayed afterdepolarizations in midmyocardial cells JF - AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY J2 - AM J PHYSIOL HEART C VL - 44 PY - 1998 SP - H1979 EP - H1992 SN - 0363-6135 UR - https://m2.mtmt.hu/api/publication/20011535 ID - 20011535 LA - English DB - MTMT ER - TY - JOUR AU - Aggarwal, R AU - Pu, J L AU - Boyden, P A TI - Ca2+-dependent outward currents in myocytes from epicardial border zone of 5-day infarcted canine heart JF - AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY J2 - AM J PHYSIOL HEART C VL - 42 PY - 1997 SP - H1386 EP - H1394 SN - 0363-6135 UR - https://m2.mtmt.hu/api/publication/20011540 ID - 20011540 LA - English DB - MTMT ER - TY - JOUR AU - Diaz, M E AU - Trafford, A W AU - Eisner, D A TI - Different time courses of Na+-Ca2+ exchange and Ca2+-activated chloride current in isolated ferret ventricular myocytes. JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 504P PY - 1997 SP - P91 EP - P92 SN - 0022-3751 UR - https://m2.mtmt.hu/api/publication/20011539 ID - 20011539 LA - English DB - MTMT ER - TY - JOUR AU - Patterson, E AU - Scherlag, B J AU - Lazzara, R TI - Early afterdepolarizations produced by d,l-sotalol and clofilium JF - JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY J2 - J CARDIOVASC ELECTR VL - 8 PY - 1997 SP - 667 EP - 678 PG - 12 SN - 1045-3873 UR - https://m2.mtmt.hu/api/publication/20011542 ID - 20011542 LA - English DB - MTMT ER - TY - JOUR AU - Patterson, E AU - Scherlag, BJ AU - Szabo, B AU - Lazzara, R TI - Facilitation of epinephrine-induced afterdepolarizations by class III antiarrhythmic drugs JF - JOURNAL OF ELECTROCARDIOLOGY J2 - J ELECTROCARDIOL VL - 30 PY - 1997 IS - 3 SP - 217 EP - 224 PG - 8 SN - 0022-0736 DO - 10.1016/S0022-0736(97)80007-6 UR - https://m2.mtmt.hu/api/publication/24610876 ID - 24610876 LA - English DB - MTMT ER - TY - JOUR AU - Collier, M L AU - Levesque, P C AU - Kenyon, J L AU - Hume, J R TI - Unitary Cl- channels activated by cytoplasmic Ca2+ in canine ventricular myocytes JF - CIRCULATION RESEARCH J2 - CIRC RES VL - 78 PY - 1996 SP - 936 EP - 944 PG - 9 SN - 0009-7330 UR - https://m2.mtmt.hu/api/publication/20011544 ID - 20011544 LA - English DB - MTMT ER - TY - JOUR AU - Xie, WW AU - Kaetzel, MA AU - Bruzik, KS AU - Dedman, JR AU - Shears, SB AU - Nelson, DJ TI - Inositol 3,4,5,6-tetrakisphosphate inhibits the calmodulin-dependent protein kinase II-activated chloride conductance in T84 colonic epithelial cells JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM VL - 271 PY - 1996 IS - 24 SP - 14092 EP - 14097 PG - 6 SN - 0021-9258 DO - 10.1074/jbc.271.24.14092 UR - https://m2.mtmt.hu/api/publication/20952530 ID - 20952530 LA - English DB - MTMT ER - TY - CHAP AU - Callewaert, G AU - Sipido, K ED - J., Vereecke ED - PP., van Bogaert ED - F., Verdonck TI - Calcium diffusion in cardiac cells T2 - Potassium channels in normal and pathological conditions PB - Leuven University Press PB - Leuven University Press PY - 1995 SP - 440 EP - 443 PG - 4 UR - https://m2.mtmt.hu/api/publication/20011746 ID - 20011746 LA - English DB - MTMT ER - TY - JOUR AU - Callewaert, Geert AU - Sipido, Karin R TI - Calcium diffusion in cardiac cells PY - 1995 UR - https://m2.mtmt.hu/api/publication/24522889 ID - 24522889 LA - English DB - MTMT ER - TY - JOUR AU - Sipido, Karin R AU - Callewaert, Geert TI - [Ca2+]i-dependent membrane currents in guinea-pig ventricular cells in the absence of Na/Ca exchange JF - PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY J2 - PFLUG ARCH EUR J PHY VL - 430 PY - 1995 SP - 871 EP - 878 PG - 8 SN - 0031-6768 DO - 10.1007/BF00386189 UR - https://m2.mtmt.hu/api/publication/24522888 ID - 24522888 LA - English DB - MTMT ER - TY - CHAP AU - Vereecke, J ED - J., Vereecke ED - PP., van Bogaert ED - F., Verdonck TI - From K fluxes to single K channel analysis T2 - Potassium channels in normal and pathological conditions PB - Leuven University Press PB - Leuven University Press PY - 1995 SP - 15 EP - 32 PG - 18 UR - https://m2.mtmt.hu/api/publication/20011743 ID - 20011743 LA - English DB - MTMT ER - TY - JOUR AU - van Stipdonk, A M W TI - Reperfusion arrhythmias PY - 0 UR - https://m2.mtmt.hu/api/publication/24522891 ID - 24522891 LA - English DB - MTMT ER -