@article{MTMT:32463867, title = {Edward Carmeliet: his contributions and scientific legacy}, url = {https://m2.mtmt.hu/api/publication/32463867}, author = {Sipido, Karin R. and Eisner, David A.}, doi = {10.1113/JP282357}, journal-iso = {J PHYSIOL-LONDON}, journal = {JOURNAL OF PHYSIOLOGY-LONDON}, volume = {599}, unique-id = {32463867}, issn = {0022-3751}, keywords = {PURKINJE-CELLS; SARCOPLASMIC-RETICULUM; CARDIAC MYOCYTES; membrane currents; CA2+ RELEASE; Neurosciences; EUROPEAN-SOCIETY; K+ CURRENT; CHLORIDE-IONS; CL-CURRENT}, year = {2021}, eissn = {1469-7793}, pages = {4727-4729} } @article{MTMT:32106256, title = {Cardiac Transmembrane Ion Channels and Action Potentials: Cellular Physiology and Arrhythmogenic Behavior}, url = {https://m2.mtmt.hu/api/publication/32106256}, author = {Varró, András and Tomek, Jakub and Nagy, Norbert and Virág, László and Passini, Elisa and Rodriguez, Blanca and Baczkó, István}, doi = {10.1152/physrev.00024.2019}, journal-iso = {PHYSIOL REV}, journal = {PHYSIOLOGICAL REVIEWS}, volume = {101}, unique-id = {32106256}, issn = {0031-9333}, abstract = {Cardiac arrhythmias are among the leading causes of mortality. They often arise from alterations in the electro-physiological properties of cardiac cells and their underlying ionic mechanisms. It is therefore critical to further unravel the pathophysiology of the ionic basis of human cardiac electrophysiology in health and disease. In the first part of this review, current knowledge on the differences in ion channel expression and properties of the ionic processes that determine the morphology and properties of cardiac action potentials and calcium dynamics from cardiomyocytes in different regions of the heart are described. Then the cellular mechanisms promoting arrhythmias in congenital or acquired conditions of ion channel function (electrical remodeling) are discussed. The focus is on human-relevant findings obtained with clinical, experimental, and computational studies, given that interspecies differences make the extrapolation from animal experiments to human clinical settings difficult. Deepening the understanding of the diverse pathophysiology of human cellular electrophysiology will help in developing novel and effective antiarrhythmic strategies for specific subpopulations and disease conditions.}, keywords = {ION CHANNELS; HEART; action potential; Arrhythmia; TRANSIENT OUTWARD CURRENT; LATE SODIUM CURRENT; EPICARDIAL BORDER ZONE; loss-of-function; SICK SINUS SYNDROME; SHORT-QT SYNDROME; HUMAN VENTRICULAR MYOCYTES; RECTIFIER K+-CURRENT; ACTIVATED CHLORIDE CURRENT}, year = {2021}, eissn = {1522-1210}, pages = {1083-1176}, orcid-numbers = {Varró, András/0000-0003-0745-3603; Baczkó, István/0000-0002-9588-0797} } @article{MTMT:32076870, title = {The role of Ca2+ activated Cl- channels in blood pressure control}, url = {https://m2.mtmt.hu/api/publication/32076870}, author = {Matchkov, Vladimir V. and Boedtkjer, Donna M. and Aalkjaer, Christian}, doi = {10.1016/j.coph.2015.02.003}, journal-iso = {CURR OPIN PHARMACOL}, journal = {CURRENT OPINION IN PHARMACOLOGY}, volume = {21}, unique-id = {32076870}, issn = {1471-4892}, abstract = {Ca2+-activated Cl- channels (CaCCs) have numerous functions in the body and are potential players in the control of blood pressure. The CaCCs represent a heterologous group including at least two protein families; TMEM16 and bestrophins. CaCCs expression has been shown in the kidney, the heart and blood vessels. Agonist-stimulated Ca2+-activated Cl- current is important for secretion in kidney epithelia, generation of a repolarizing current in the heart and amplification of excitation-contraction coupling in vascular smooth muscle cells. Changes in CaCC expression are shown in association with hypertension, kidney cysts, sudden cardiac death and arrhythmias. This review discusses recent advances in studies concerning the role of CaCC for blood pressure control with focus on the kidney, the heart and blood vessels.}, keywords = {INTRACELLULAR CALCIUM; SMOOTH-MUSCLE-CELLS; TRANSIENT OUTWARD CURRENT; VASCULAR ENDOTHELIAL-CELLS; DELAYED AFTERDEPOLARIZATIONS; SENSITIVE HYPERTENSION; CHLORIDE-CURRENT; ANTIARRHYTHMIC APPROACH; INDUCED DEPOLARIZATION}, year = {2015}, eissn = {1471-4973}, pages = {127-137}, orcid-numbers = {Matchkov, Vladimir V./0000-0002-3303-1095; Boedtkjer, Donna M./0000-0003-1736-3484; Aalkjaer, Christian/0000-0003-2618-4015} } @article{MTMT:24522881, title = {A monounsaturated fatty acid (oleic acid) modulates electrical activity in atrial myocytes with calcium and sodium dysregulation}, url = {https://m2.mtmt.hu/api/publication/24522881}, author = {Lin, Yung-Kuo and Chen, Yao-Chang and Kao, Yu-Hsun and Tsai, Chin-Feng and Yeh, Yung-Hsin and Huang, Jin-Long and Cheng, Chen-Chuan and Chen, Shih-Ann and Chen, Yi-Jen}, journal-iso = {INT J CARDIOL}, journal = {INTERNATIONAL JOURNAL OF CARDIOLOGY}, volume = {176}, unique-id = {24522881}, issn = {0167-5273}, year = {2014}, eissn = {1874-1754}, pages = {191-198} } @article{MTMT:20969441, title = {Cardiac Purkinje cells}, url = {https://m2.mtmt.hu/api/publication/20969441}, author = {Boyden, PA and Hirose, M and Dun, W}, doi = {10.1016/j.hrthm.2009.09.017}, journal-iso = {HEART RHYTHM}, journal = {HEART RHYTHM}, volume = {7}, unique-id = {20969441}, issn = {1547-5271}, year = {2010}, eissn = {1556-3871}, pages = {127-135} } @article{MTMT:20294196, title = {Comparison of K+ currents in cardiac Purkinje cells isolated from rabbit and dog}, url = {https://m2.mtmt.hu/api/publication/20294196}, author = {Dumaine, R and Cordeiro, JM}, doi = {10.1016/j.yjmcc.2006.10.019}, journal-iso = {J MOL CELL CARDIOL}, journal = {JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY}, volume = {42}, unique-id = {20294196}, issn = {0022-2828}, year = {2007}, eissn = {1095-8584}, pages = {378-389} } @book{MTMT:24522882, title = {Molecular and functional expression of the murine Bestrophin family from cardiovascular tissues}, url = {https://m2.mtmt.hu/api/publication/24522882}, author = {O'Driscoll, Kate E}, publisher = {ProQuest}, unique-id = {24522882}, year = {2007} } @article{MTMT:25685316, title = {Calcium and arrhythmogenesis}, url = {https://m2.mtmt.hu/api/publication/25685316}, author = {Ter, Keurs Henk E D J and Boyden, Penelope A}, doi = {10.1152/physrev.00011.2006}, journal-iso = {PHYSIOL REV}, journal = {PHYSIOLOGICAL REVIEWS}, volume = {87}, unique-id = {25685316}, issn = {0031-9333}, year = {2007}, eissn = {1522-1210}, pages = {457-506} } @article{MTMT:25685325, title = {Would modulation of intracellular Ca(2+) be antiarrhythmic?}, url = {https://m2.mtmt.hu/api/publication/25685325}, author = {Boyden, PA and ter Keurs, H}, doi = {10.1016/j.pharmthera.2005.03.011}, journal-iso = {PHARMACOL THERAPEUT}, journal = {PHARMACOLOGY & THERAPEUTICS}, volume = {108}, unique-id = {25685325}, issn = {0163-7258}, year = {2005}, eissn = {1879-016X}, pages = {149-179} } @article{MTMT:20952421, title = {Calcium-activated chloride channels}, url = {https://m2.mtmt.hu/api/publication/20952421}, author = {Hartzell, C and Putzier, I and Arreola, J}, doi = {10.1146/annurev.physiol.67.032003.154341}, journal-iso = {ANNU REV PHYSIOL}, journal = {ANNUAL REVIEW OF PHYSIOLOGY}, volume = {67}, unique-id = {20952421}, issn = {0066-4278}, year = {2005}, eissn = {1545-1585}, pages = {719-758} } @article{MTMT:20011868, title = {Pozitív inotropia farmakológiai Ca2+-érzékenyítés árán: preklinikai és klinikai tapasztalatok Ca2+-érzékenyítőkkel}, url = {https://m2.mtmt.hu/api/publication/20011868}, author = {Édes, I}, journal-iso = {CARDIOL HUNG}, journal = {CARDIOLOGIA HUNGARICA}, volume = {34}, unique-id = {20011868}, issn = {0133-5596}, year = {2004}, eissn = {1588-0230}, pages = {E52-E56} } @article{MTMT:20432896, title = {Integrated Ca2+ management in cardiac myocytes}, url = {https://m2.mtmt.hu/api/publication/20432896}, author = {Shannon, TR and Bers, DM}, volume = {1015}, unique-id = {20432896}, year = {2004}, pages = {28-38} } @article{MTMT:24522884, title = {Cardiac Channelopathies}, url = {https://m2.mtmt.hu/api/publication/24522884}, author = {Marban, Eduardo}, journal-iso = {HEART VIEW}, journal = {HEART VIEWS}, volume = {4}, unique-id = {24522884}, issn = {1995-705X}, year = {2003}, eissn = {0976-5123}, pages = {4} } @article{MTMT:20011515, title = {Isolation and morphology of single Purkinje cells from the porcine heart}, url = {https://m2.mtmt.hu/api/publication/20011515}, author = {Stankovicova, T and Bito, V and Heinzel, F and Mubagwa, K and Sipido, K R}, journal-iso = {GEN PHYSIOL BIOPHYS}, journal = {GENERAL PHYSIOLOGY AND BIOPHYSICS}, volume = {22}, unique-id = {20011515}, issn = {0231-5882}, year = {2003}, eissn = {1338-4325}, pages = {329-340} } @article{MTMT:21130563, title = {The endogenous calcium-activated Cl channel in Xenopus oocytes: A physiologically and biophysically rich model system}, url = {https://m2.mtmt.hu/api/publication/21130563}, author = {Machaca, K and Qu, Z Q and Kuruma, A and Hartzell, H C and McCarty, N}, journal-iso = {CURR TOP MEMBR}, journal = {CURRENT TOPICS IN MEMBRANES}, volume = {53}, unique-id = {21130563}, issn = {1063-5823}, year = {2002}, pages = {3-39} } @article{MTMT:24274799, title = {Cardiac channelopathies}, url = {https://m2.mtmt.hu/api/publication/24274799}, author = {Marban, E}, doi = {10.1038/415213a}, journal-iso = {NATURE}, journal = {NATURE}, volume = {415}, unique-id = {24274799}, issn = {0028-0836}, year = {2002}, eissn = {1476-4687}, pages = {213-218} } @article{MTMT:20434199, title = {Ca2+ overload evokes a transient outward current in guinea-pig ventricular myocytes}, url = {https://m2.mtmt.hu/api/publication/20434199}, author = {Nakajima, I and Watanabe, H and Iino, K and Saito, T and Miura, M}, doi = {10.1253/circj.66.87}, journal-iso = {CIRC J}, journal = {CIRCULATION JOURNAL: OFFICIAL JOURNAL OF THE JAPANESE CIRCULATION SOCIETY}, volume = {66}, unique-id = {20434199}, issn = {1346-9843}, year = {2002}, eissn = {1347-4820}, pages = {87-92} } @{MTMT:31379400, title = {Excitation-Contraction Coupling in Cardiac Muscle}, url = {https://m2.mtmt.hu/api/publication/31379400}, author = {Trafford, A. W. and Eisner, D. A.}, booktitle = {Molecular Control Mechanisms in Striated Muscle Contraction}, doi = {10.1007/978-94-015-9926-9_2}, unique-id = {31379400}, abstract = {Excitation-contraction coupling concerns the processes linking electrical excitation of the surface membrane to contraction. As shown in Fig. 1 A, the action potential produces a systolic increase of calcium that then activates contraction. This chapter will focus on the control of calcium and will largely ignore the contractile protein mechanisms that follow the increase of Ca. These events are described in detail in other chapters. Equally, on grounds of space, we will largely ignore the whole field of pharmacological modulation of e-c coupling. The reader is directed to the following books for recent summaries of the broad field of cardiac electrophysiology and contraction (Bers, 2001;Zipes & Jalife, 2000;Sperelakis et al., 2001). An overview of cellular Ca handling is shown in Fig. 1A.}, year = {2002}, pages = {49-89} } @book{MTMT:20011753, title = {Excitation-contraction coupling and cardiac contractile force}, url = {https://m2.mtmt.hu/api/publication/20011753}, author = {Bers, DM}, publisher = {Kluwer; Kluwer Academic Press}, unique-id = {20011753}, year = {2001} } @article{MTMT:20011522, title = {Early and delayed afterdepolarizations in rabbit heart Purkinje cells viewed by confocal microscopy}, url = {https://m2.mtmt.hu/api/publication/20011522}, author = {Cordeiro, J M and Bridge, J H B and Spitzer, K W}, journal-iso = {CELL CALCIUM}, journal = {CELL CALCIUM}, volume = {29}, unique-id = {20011522}, issn = {0143-4160}, year = {2001}, eissn = {1532-1991}, pages = {289-297} } @article{MTMT:20011523, title = {Location of the initiation site of calcium transients and sparks in rabbit heart Purkinje cells}, url = {https://m2.mtmt.hu/api/publication/20011523}, author = {Cordeiro, J M and Spitzer, K W and Giles, W R and Ershler, P E and Cannell, M B and Bridge, J H B}, journal-iso = {J PHYSIOL-LONDON}, journal = {JOURNAL OF PHYSIOLOGY-LONDON}, volume = {531}, unique-id = {20011523}, issn = {0022-3751}, year = {2001}, eissn = {1469-7793}, pages = {301-314} } @article{MTMT:20011521, title = {The role of intracellular Ca buffers in determining the shape of the systolic Ca transient in cardiac ventricular myocytes}, url = {https://m2.mtmt.hu/api/publication/20011521}, author = {Diaz, M E and Trafford, A W and Eisner, D A}, journal-iso = {PFLUG ARCH EUR J PHY}, journal = {PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY}, volume = {442}, unique-id = {20011521}, issn = {0031-6768}, year = {2001}, eissn = {1432-2013}, pages = {96-100} } @article{MTMT:20011520, title = {Functional geometry of the permeation pathway of Ca2+-activated Cl- channels inferred from analysis of voltage-dependent block}, url = {https://m2.mtmt.hu/api/publication/20011520}, author = {Qu, Z Q and Hartzell, H C}, journal-iso = {J BIOL CHEM}, journal = {JOURNAL OF BIOLOGICAL CHEMISTRY}, volume = {276}, unique-id = {20011520}, issn = {0021-9258}, year = {2001}, eissn = {1083-351X}, pages = {18423-18429} } @article{MTMT:24274802, title = {Ionic mechanism of delayed afterdepolarizations in ventricular cells isolated from human end-stage failing hearts}, url = {https://m2.mtmt.hu/api/publication/24274802}, author = {Verkerk, AO and Veldkamp, MW and Baartscheer, A and Schumacher, CA and Klopping, C and van Ginneken, ACG and Ravesloot, JH}, doi = {10.1161/hc4701.099577}, journal-iso = {CIRCULATION}, journal = {CIRCULATION}, volume = {104}, unique-id = {24274802}, issn = {0009-7322}, year = {2001}, eissn = {1524-4539}, pages = {2728-2733} } @article{MTMT:20011526, title = {Ca2+ transients and Ca2+ waves in Purkinje cells - Role in action potential initiation}, url = {https://m2.mtmt.hu/api/publication/20011526}, author = {Boyden, P A and Pu, J L and Pinto, J and Ter, Keurs H E D J}, journal-iso = {CIRC RES}, journal = {CIRCULATION RESEARCH}, volume = {86}, unique-id = {20011526}, issn = {0009-7330}, year = {2000}, eissn = {1524-4571}, pages = {448-455} } @article{MTMT:20011527, title = {Anion transport in heart}, url = {https://m2.mtmt.hu/api/publication/20011527}, author = {Hume, J R and Duan, D and Collier, M L and Yamazaki, J and Horowitz, B}, journal-iso = {PHYSIOL REV}, journal = {PHYSIOLOGICAL REVIEWS}, volume = {80}, unique-id = {20011527}, issn = {0031-9333}, year = {2000}, eissn = {1522-1210}, pages = {31-81} } @article{MTMT:21130587, title = {Bimodal control of a Ca2+-activated Cl- channel by different Ca2+ signals}, url = {https://m2.mtmt.hu/api/publication/21130587}, author = {Kuruma, A and Hartzell, H C}, journal-iso = {J GEN PHYSIOL}, journal = {JOURNAL OF GENERAL PHYSIOLOGY}, volume = {115}, unique-id = {21130587}, issn = {0022-1295}, year = {2000}, eissn = {1540-7748}, pages = {59-80} } @inbook{MTMT:1009038, title = {A szív- és simaizomsejtek ingerületi folyamatai és celluláris Ca2+ anyagcseréje}, url = {https://m2.mtmt.hu/api/publication/1009038}, author = {Papp, Zoltán and Édes, István}, booktitle = {A szív- és simaizom Ca2+-anyagcseréje: elmélet, klinikum}, unique-id = {1009038}, year = {2000}, pages = {17-89} } @article{MTMT:20011565, title = {Sarcoplasmic reticulum Ca2+ release causes myocyte depolarization - Underlying mechanism and threshold for triggered action potentials}, url = {https://m2.mtmt.hu/api/publication/20011565}, author = {Schlotthauer, K and Bers, D M}, doi = {10.1161/01.RES.87.9.774}, journal-iso = {CIRC RES}, journal = {CIRCULATION RESEARCH}, volume = {87}, unique-id = {20011565}, issn = {0009-7330}, year = {2000}, eissn = {1524-4571}, pages = {774-780} } @article{MTMT:20011525, title = {I-NaCa contributes to electrical heterogeneity within the canine ventricle}, url = {https://m2.mtmt.hu/api/publication/20011525}, author = {Zygmunt, A C and Goodrow, R J and Antzelevitch, C}, journal-iso = {AM J PHYSIOL HEART C}, journal = {AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY}, volume = {278}, unique-id = {20011525}, issn = {0363-6135}, year = {2000}, eissn = {1522-1539}, pages = {H1671-H1678} } @article{MTMT:26320836, title = {Cardiac ionic currents and acute ischemia: From channels to arrhythmias}, url = {https://m2.mtmt.hu/api/publication/26320836}, author = {Carmeliet, E}, journal-iso = {PHYSIOL REV}, journal = {PHYSIOLOGICAL REVIEWS}, volume = {79}, unique-id = {26320836}, issn = {0031-9333}, year = {1999}, eissn = {1522-1210}, pages = {917-1017} } @article{MTMT:24610709, title = {Repercussions of pharmacologic reduction in ionic currents on action potential configuration in rabbit Purkinje fibers: Are they indicative of proarrhythmic potential?}, url = {https://m2.mtmt.hu/api/publication/24610709}, author = {Dumotier, BM and Adamantidis, MM and Puisieux, FL and Bastide, MM and Dupuis, BA}, doi = {10.1002/(SICI)1098-2299(199906)47:2<63::AID-DDR2>3.0.CO;2-5}, journal-iso = {DRUG DEVELOP RES}, journal = {DRUG DEVELOPMENT RESEARCH}, volume = {47}, unique-id = {24610709}, issn = {0272-4391}, year = {1999}, eissn = {1098-2299}, pages = {63-76} } @article{MTMT:1117232, title = {Characterization of a [Ca2+]-dependent current in human atrial and ventricular cardiomyocytes in the absence of Na+ and K+}, url = {https://m2.mtmt.hu/api/publication/1117232}, author = {Koster, O F and Szigeti, Gyula Péter and Beuckelmann, D J}, doi = {10.1016/S0008-6363(98)00202-8}, journal-iso = {CARDIOVASC RES}, journal = {CARDIOVASCULAR RESEARCH}, volume = {41}, unique-id = {1117232}, issn = {0008-6363}, abstract = {Objectives: In situations of [Ca2+](i) overload, arrhythmias are believed to be triggered by delayed after depolarizations, which are generated by a transient inward current I(TI). This study was designed to examine [Ca2+](i)-dependent membrane currents in the absence of the Na+/Ca2+-exchanger as possible contributors to I(TI) in human cardiac cells. Methods: The whole cell voltage clamp technique was used for electrophysiological measurements in human atrial and ventricular cardiomyocytes. [Ca2+](i)-measurements were performed using the fluorescent Ca2+-indicator fura-2. All solutions were Na+-free. Voltage-independent [Ca2+](i)-measurements were performed using applications. Results: In atrial myocytes, caffeine induced a transient membrane current in the absence of Na+ and K+. This current could be suppressed by internal EGTA (10 mM). Cl- did not contribute to this current. Experiments with different cations suggested non-selectivity for Cs+ and Li+, whereas N-methyl-D-glucamine appeared to be impermeable. Voltage ramps indicated a linear current-voltage relation in the range of +80 to -80 mV. Fluorescence measurements revealed a dissociation between the time courses of current and bulk [Ca2+](i)- signal. In ventricular cardiomyocytes, caffeine failed to induce transient currents in 54 cells from 22 different patients with or without terminal heart failure. Conclusions: In human atrial cardiomyocytes, a [Ca2+](i)- dependent nonspecific cation channel is expressed and may contribute to triggered arrhythmias in situations of [Ca2+](i)-overload. No evidence could be found for the existence of a [Ca2+](i)-dependent chloride current in atrial cells. In ventricular cells, neither a [Ca2+](i)-dependent nonspecific cation channel nor a [Ca-2+](i)-dependent chloride channel seems to be expressed. Possible delayed after depolarizations in human ventricular myocardium might therefore be carried by the Na+/Ca2+- exchanger alone.}, year = {1999}, eissn = {1755-3245}, pages = {175-187}, orcid-numbers = {Szigeti, Gyula Péter/0000-0003-0411-9992} } @article{MTMT:1005461, title = {Calcium-dependent modulation of the plateau phase of action potential in isolated ventricular cells of rabbit heart}, url = {https://m2.mtmt.hu/api/publication/1005461}, author = {Papp, Zoltán and Peineau, N and Szigeti, Gyula Péter and Argibay, J and Kovács, László}, doi = {10.1046/j.1365-201x.1999.00599.x}, journal-iso = {ACTA PHYSIOL SCAND}, journal = {ACTA PHYSIOLOGICA SCANDINAVICA}, volume = {167}, unique-id = {1005461}, issn = {0001-6772}, abstract = {[Ca2+](i)-dependent modulation of the action potential has been studied in Fura-2 dialysed ventricular myocytes of the rabbit using the whole-cell current-clamp method. Fifteen consecutive action potentials (AP(1)-AP(15)) and [Ca2+](i) transients were elicited at a frequency of 0.2 Hz. A single, brief application of caffeine (during AP(9)) first enhanced and thereafter attenuated the [Ca2+](i) transients accompanying AP(9) and AP(10)-AP(12), respectively. This approach provided direct comparison between time courses of action potentials: during the initial steady state (e.g. AP(8)) and when Ca2+ release from the sarcoplasmic reticulum was increased by caffeine (AP(9)) or decreased by depletion (AP(10)). The increase in [Ca2+](i) facilitated repolarization and decreased action potential duration. However, action potentials at reduced Ca2+ release (AP(10)) had longer duration than during steady state. The caffeine-induced changes in L-type Ca2+ current (I-Ca,I-L), during voltage-clamp conditions partially explained the effects of caffeine on action potentials. When I-Ca,I-L was blocked by 500 mu mol L-1 Cd2+ enhanced [Ca2+](i) transients revealed an extra current component which was outward at +10 mV and inward at the resting membrane potential (most probably the transient inward current). in the presence of Cd2+, however, AP(8) and AP(10) had identical time courses, suggesting that I-Ca,I-L alone was responsible for the lengthening of AP(10). Alterations in the transmembrane Na+ gradient resulted in changes of the steady stale action potential durations (AP(8)) consistently with the expected modulation of the Na+-Ca2+ exchange current. However, the contribution of this current to the [Ca2+](i)-dependent behaviour of action potential plateau could not be demonstrated.}, year = {1999}, eissn = {1365-201X}, pages = {119-129}, orcid-numbers = {Szigeti, Gyula Péter/0000-0003-0411-9992} } @book{MTMT:24522887, title = {Genetic Aspects of Cardiac Arrhythmia Syndromes}, url = {https://m2.mtmt.hu/api/publication/24522887}, author = {Postma, Alex Vincent}, unique-id = {24522887}, year = {1999} } @article{MTMT:20011533, title = {Insights into the structure, distribution and function of the cardiac chloride channels}, url = {https://m2.mtmt.hu/api/publication/20011533}, author = {Sorota, S}, journal-iso = {CARDIOVASC RES}, journal = {CARDIOVASCULAR RESEARCH}, volume = {42}, unique-id = {20011533}, issn = {0008-6363}, year = {1999}, eissn = {1755-3245}, pages = {361-376} } @article{MTMT:20011529, title = {Two types of action potential configuration in single cardiac Purkinje cells of sheep}, url = {https://m2.mtmt.hu/api/publication/20011529}, author = {Verkerk, A O and Veldkamp, M W and Abbate, F and Antoons, G and Bouman, L N and Ravesloot, J H and van Ginneken, A C G}, journal-iso = {AM J PHYSIOL HEART C}, journal = {AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY}, volume = {277}, unique-id = {20011529}, issn = {0363-6135}, year = {1999}, eissn = {1522-1539}, pages = {H1299-H1310} } @article{MTMT:20011537, title = {Repolarizing K+ currents in rabbit heart Purkinje cells}, url = {https://m2.mtmt.hu/api/publication/20011537}, author = {Cordeiro, J M and Spitzer, K W and Giles, W R}, journal-iso = {J PHYSIOL-LONDON}, journal = {JOURNAL OF PHYSIOLOGY-LONDON}, volume = {508}, unique-id = {20011537}, issn = {0022-3751}, year = {1998}, eissn = {1469-7793}, pages = {811-823} } @article{MTMT:20011536, title = {Role of cardiac chloride currents in changes in action potential characteristics and arrhythmias}, url = {https://m2.mtmt.hu/api/publication/20011536}, author = {Hiraoka, M and Kawano, S and Hirano, Y and Furukawa, T}, journal-iso = {CARDIOVASC RES}, journal = {CARDIOVASCULAR RESEARCH}, volume = {40}, unique-id = {20011536}, issn = {0008-6363}, year = {1998}, eissn = {1755-3245}, pages = {23-33} } @article{MTMT:1005465, title = {Calcium-activated transient membrane currents are carried mainly by chloride ions in isolated atrial, ventricular and Purkinje cells of rabbit heart}, url = {https://m2.mtmt.hu/api/publication/1005465}, author = {Szigeti, Gyula Péter and Rusznak, Z and Kovacs, L and Papp, Zoltán}, doi = {10.1113/expphysiol.1998.sp004097}, journal-iso = {EXP PHYSIOL}, journal = {EXPERIMENTAL PHYSIOLOGY}, volume = {83}, unique-id = {1005465}, issn = {0958-0670}, abstract = {Under physiological conditions, calcium-dependent ([Ca2+](i)-dependent) Cl- currents (I-Cl(Ca)) have been suggested to participate in the repolarizing processes. In this paper, the possible contribution of I-Cl(Ca) to transient inward currents and, hence to arrhythmias, has been studied in myocytes from the working myocardium and from the conductive system. Single atrial, ventricular and Purkinje cells, isolated enzymatically from rabbit heart, have been studied under whole-cell voltage-clamp and were internally perfused with the fluorescent Ca2+ indicator, fura-2 (100 mu M). Ca2+ release from the sarcoplasmic reticulum was either induced by external application of caffeine or occurred spontaneously in Ca2+-overloaded cells. Membrane currents accompanying Ca2+ transients showed linear current-voltage characteristics between -60 and +80 mV as evidenced from fast voltage ramps. When intra- and extracellular Cl- concentrations were kept symmetrical in the absence of the Na+-Ca2+ exchange mechanism, transient currents had a reversal potential close to 0 mV. Reduction of external Cl- concentration shifted this reversal potential towards the new Cl- equilibrium potential. Neither the time course of the transient currents nor the shift in their reversal potentials was significantly affected by the presence of Na+. Approximately 90 % of this current was blocked by the application of the Cl- channel blocker, anthracene-9-carboxylic acid (0.5 mM) at +80 mV. It is concluded, that [Ca2+](i)-activated transient membrane currents in atrial, ventricular and Purkinje cells of rabbit heart are mainly due to the activation of a [Ca2+](i)- dependent Cl- current.}, year = {1998}, eissn = {1469-445X}, pages = {137-153}, orcid-numbers = {Szigeti, Gyula Péter/0000-0003-0411-9992} } @article{MTMT:20011535, title = {I-NaCa and I-Cl(Ca) contribute to isoproterenol-induced delayed afterdepolarizations in midmyocardial cells}, url = {https://m2.mtmt.hu/api/publication/20011535}, author = {Zygmunt, A C and Goodrow, R J and Weigel, C M}, journal-iso = {AM J PHYSIOL HEART C}, journal = {AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY}, volume = {44}, unique-id = {20011535}, issn = {0363-6135}, year = {1998}, eissn = {1522-1539}, pages = {H1979-H1992} } @article{MTMT:20011540, title = {Ca2+-dependent outward currents in myocytes from epicardial border zone of 5-day infarcted canine heart}, url = {https://m2.mtmt.hu/api/publication/20011540}, author = {Aggarwal, R and Pu, J L and Boyden, P A}, journal-iso = {AM J PHYSIOL HEART C}, journal = {AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY}, volume = {42}, unique-id = {20011540}, issn = {0363-6135}, year = {1997}, eissn = {1522-1539}, pages = {H1386-H1394} } @article{MTMT:20011539, title = {Different time courses of Na+-Ca2+ exchange and Ca2+-activated chloride current in isolated ferret ventricular myocytes.}, url = {https://m2.mtmt.hu/api/publication/20011539}, author = {Diaz, M E and Trafford, A W and Eisner, D A}, journal-iso = {J PHYSIOL-LONDON}, journal = {JOURNAL OF PHYSIOLOGY-LONDON}, volume = {504P}, unique-id = {20011539}, issn = {0022-3751}, year = {1997}, eissn = {1469-7793}, pages = {P91-P92} } @article{MTMT:20011542, title = {Early afterdepolarizations produced by d,l-sotalol and clofilium}, url = {https://m2.mtmt.hu/api/publication/20011542}, author = {Patterson, E and Scherlag, B J and Lazzara, R}, journal-iso = {J CARDIOVASC ELECTR}, journal = {JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY}, volume = {8}, unique-id = {20011542}, issn = {1045-3873}, year = {1997}, eissn = {1540-8167}, pages = {667-678} } @article{MTMT:24610876, title = {Facilitation of epinephrine-induced afterdepolarizations by class III antiarrhythmic drugs}, url = {https://m2.mtmt.hu/api/publication/24610876}, author = {Patterson, E and Scherlag, BJ and Szabo, B and Lazzara, R}, doi = {10.1016/S0022-0736(97)80007-6}, journal-iso = {J ELECTROCARDIOL}, journal = {JOURNAL OF ELECTROCARDIOLOGY}, volume = {30}, unique-id = {24610876}, issn = {0022-0736}, year = {1997}, eissn = {1532-8430}, pages = {217-224} } @article{MTMT:20011544, title = {Unitary Cl- channels activated by cytoplasmic Ca2+ in canine ventricular myocytes}, url = {https://m2.mtmt.hu/api/publication/20011544}, author = {Collier, M L and Levesque, P C and Kenyon, J L and Hume, J R}, journal-iso = {CIRC RES}, journal = {CIRCULATION RESEARCH}, volume = {78}, unique-id = {20011544}, issn = {0009-7330}, year = {1996}, eissn = {1524-4571}, pages = {936-944} } @article{MTMT:20952530, title = {Inositol 3,4,5,6-tetrakisphosphate inhibits the calmodulin-dependent protein kinase II-activated chloride conductance in T84 colonic epithelial cells}, url = {https://m2.mtmt.hu/api/publication/20952530}, author = {Xie, WW and Kaetzel, MA and Bruzik, KS and Dedman, JR and Shears, SB and Nelson, DJ}, doi = {10.1074/jbc.271.24.14092}, journal-iso = {J BIOL CHEM}, journal = {JOURNAL OF BIOLOGICAL CHEMISTRY}, volume = {271}, unique-id = {20952530}, issn = {0021-9258}, year = {1996}, eissn = {1083-351X}, pages = {14092-14097} } @{MTMT:20011746, title = {Calcium diffusion in cardiac cells}, url = {https://m2.mtmt.hu/api/publication/20011746}, author = {Callewaert, G and Sipido, K}, booktitle = {Potassium channels in normal and pathological conditions}, publisher = {Leuven University Press}, unique-id = {20011746}, year = {1995}, pages = {440-443} } @article{MTMT:24522889, title = {Calcium diffusion in cardiac cells}, url = {https://m2.mtmt.hu/api/publication/24522889}, author = {Callewaert, Geert and Sipido, Karin R}, unique-id = {24522889}, year = {1995} } @article{MTMT:24522888, title = {[Ca2+]i-dependent membrane currents in guinea-pig ventricular cells in the absence of Na/Ca exchange}, url = {https://m2.mtmt.hu/api/publication/24522888}, author = {Sipido, Karin R and Callewaert, Geert}, doi = {10.1007/BF00386189}, journal-iso = {PFLUG ARCH EUR J PHY}, journal = {PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY}, volume = {430}, unique-id = {24522888}, issn = {0031-6768}, year = {1995}, eissn = {1432-2013}, pages = {871-878} } @{MTMT:20011743, title = {From K fluxes to single K channel analysis}, url = {https://m2.mtmt.hu/api/publication/20011743}, author = {Vereecke, J}, booktitle = {Potassium channels in normal and pathological conditions}, publisher = {Leuven University Press}, unique-id = {20011743}, year = {1995}, pages = {15-32} } @article{MTMT:24522891, title = {Reperfusion arrhythmias}, url = {https://m2.mtmt.hu/api/publication/24522891}, author = {van Stipdonk, A M W}, unique-id = {24522891}, year = {0} }