TY  - JOUR
AU  - Kovács, Levente
AU  - Ferenci, Tamás
AU  - Gombos, Balázs
AU  - Füredi, András
AU  - Rudas, Imre
AU  - Szakács, Gergely
AU  - Drexler, Dániel András
TI  - Positive Impulsive Control of Tumor Therapy—A Cyber-Medical Approach
JF  - IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS: SYSTEMS
J2  - IIEEE TRANS SYST MAN CYBERN SYST
VL  - 54
PY  - 2024
IS  - 1
SP  - 597
EP  - 608
PG  - 12
SN  - 2168-2216
DO  - 10.1109/TSMC.2023.3315637
UR  - https://m2.mtmt.hu/api/publication/34168948
ID  - 34168948
AB  - Chemotherapy optimization based on mathematical models is a promising direction of personalized medicine. Personalizing, thus optimizing treatments, may have multiple advantages, from fewer side effects to lower costs. However, personalization is a complicated process in practice. We discuss a mathematical model of tumor growth and therapy optimization algorithms that can be used to personalize therapies. The therapy generation is based on the concept of keeping the drug level over a specified value. A mixed-effect model is used for parametric identification, and the doses are calculated using a two-compartment model for drug pharmacokinetics, and a nonlinear pharmacodynamics and tumor dynamics model. We propose personalized therapy generation algorithms for having a maximal effect and minimal effective doses. We handle inter- and intra-patient variability for the minimal effective dose therapy. Results from mouse experiments for the personalized therapy are discussed and the algorithms are compared to a generic protocol based on overall survival. The experimental results show that the introduced algorithms significantly increased the overall survival of the mice, demonstrating that by control engineering methods an efficient modality of cancer therapy may be possible.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Lipták, György
AU  - Hangos, Katalin
AU  - Szederkényi, Gábor
TI  - Stabilizing feedback design for time delayed polynomial systems using kinetic realizations
JF  - EUROPEAN JOURNAL OF CONTROL
J2  - EUR J CONTROL
VL  - 57
PY  - 2021
SP  - 163
EP  - 171
PG  - 8
SN  - 0947-3580
DO  - 10.1016/j.ejcon.2020.06.007
UR  - https://m2.mtmt.hu/api/publication/31381185
ID  - 31381185
N1  - Export Date: 18 November 2022            
            CODEN: EJCOF            
            Correspondence Address: Lipták, G.; Faculty of Information Technology and Bionics, Práter u. 50/a, Hungary; email: lipgyorgy@scl.sztaki.hu
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Drexler, Dániel András
AU  - Ferenci, Tamás
AU  - Lovrics, Anna
AU  - Kovács, Levente
TI  - Tumor dynamics modeling based on formal reaction kinetics
JF  - ACTA POLYTECHNICA HUNGARICA
J2  - ACTA POLYTECH HUNG
VL  - 16
PY  - 2019
IS  - 10
SP  - 31
EP  - 44
PG  - 14
SN  - 1785-8860
DO  - 10.12700/APH.16.10.2019.10.3
UR  - https://m2.mtmt.hu/api/publication/30864958
ID  - 30864958
LA  - English
DB  - MTMT
ER  -