https://m2.mtmt.hu/ hun 2026-06-15 00:12 true true 1 1 1 1 100 1 1 DESC publishedYear false ASC firstAuthor true ASC title true JournalArticle 34889417 APPROVED true Online kiadás 2024 0 false 2026-06-05T06:38:33.137+0000 2026-02-19T13:58:43.948+0000 2024-05-29T16:16:33.705+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 2026-04-19T18:07:26.210+0000 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-02-03T20:57:33.368+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Chen, Yu Hua Treatment options for immune-related adverse events associated with immune checkpoint inhibitors true true /api/journal/825 REVIEWED true false 825 false 825 true 0007-1188 1476-5381 Journal FOREIGN 183 6 1271 1287 1271 17 2026 The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies. While ICIs have shown high anti‐cancer efficacy, they also have characteristic side effects, termed immune‐related adverse events (irAEs). These side effects hinder the therapeutic potential of ICIs and, therefore, finding ways to prevent and treat them is of paramount importance. The current protocols to manage irAEs follow an empirical route of steroid administration and, in more severe cases, ICI withdrawal. However, this approach is not optimal in many cases, as there are often steroid‐refractory irAEs, and there is a potential for corticosteroid use to promote tumour progression. This review surveys the current alternative approaches to the treatments for irAEs, with the goal of summarizing and highlighting the best attempts to treat irAEs, without compromising anti‐tumour immunity and allowing for rechallenge with ICIs after resolution of the irAEs. Funding 2040702 /api/funding/2040702 false true Funding 2041076 /api/funding/2041076 false true true 2024 true true true false true false NONE 2026-06-05 false 8 0 8 7 1 8 8 8 6 8 8 7 7 7 1 0 8 7 8 7 0 4 4 D1 false 10028393 false false false 2024-06-26T09:13:25.034+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); HCEMM-SE Kardiometabolikus Immunológia Kutatócs... (SE / AOK / I / FFI); MTA-SE Momentum Kardio-Onkológia és Kardioimmun... (SE / AOK / I / FFI); MTA-SE Rendszerfarmakológiai Kutatócsoport (SE / AOK / I / FFI) 4 22 4 4 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 116853450 /api/authorship/116853450 1 0.25 true false false Author 10095585 /api/author/10095585 Chen Yu Hua true true Chen Yu Hua true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116853451 /api/authorship/116853451 2 0.25 true false false Author 10060030 /api/author/10060030 Kovács Tamás true 10060030 true Kovács Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116853452 /api/authorship/116853452 3 0.25 false false false Author 10010125 /api/author/10010125 Ferdinandy Péter true 10010125 true Ferdinandy Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 116853453 /api/authorship/116853453 4 0.25 false true true Author 10028393 /api/author/10028393 Varga Zoltán true 10028393 true Varga Zoltán V. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 26277238 /api/publicationidentifier/26277238 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1111/bph.16405 https://doi.org/10.1111/bph.16405 false true PublicationIdentifier 26416979 /api/publicationidentifier/26416979 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001232023400001 https://www.webofscience.com/wos/woscc/full-record/001232023400001 true true PublicationIdentifier 26546432 /api/publicationidentifier/26546432 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85194824208 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85194824208 true true PublicationIdentifier 26277239 /api/publicationidentifier/26277239 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38803135 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38803135&dopt=Abstract false true PublicationIdentifier 31512319 /api/publicationidentifier/31512319 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16405 https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16405 false true PublicationIdentifier 31856846 /api/publicationidentifier/31856846 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true NONE IDENTICAL https://www.scopus.com/pages/publications/85194824208?origin=resultslist https://www.scopus.com/pages/publications/85194824208?origin=resultslist false true SjrRating 11716307 /api/sjrrating/11716307 17 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3004 /api/classificationexternal/3004 true 3004 true D1 FROM_LAST_YEAR true true /api/publication/34889417 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10095585"><a href="/gui2/?type=authors&mode=browse&sel=10095585" target="_blank">Chen Yu Hua (<span class="authorship-author-name">Chen Yu Hua</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060030"><a href="/gui2/?type=authors&mode=browse&sel=10060030" target="_blank">Kovács Tamás<sup>*</sup> (<span class="authorship-author-name">Kovács Tamás</span> <span class="authorAux-mtmt"> Molekuláris orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM-SE Kardiometabolikus Immunológia Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Momentum Kardio-Onkológia és Kardioimmunológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028393"><a href="/gui2/?type=authors&mode=browse&sel=10028393" target="_blank">Varga Zoltán V. ✉ (<span class="authorship-author-name">Varga Zoltán</span> <span class="authorAux-mtmt"> kardiovaszkuláris kutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Rendszerfarmakológiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM-SE Kardiometabolikus Immunológia Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Momentum Kardio-Onkológia és Kardioimmunológia Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34889417" target="_blank">Treatment options for immune-related adverse events associated with immune checkpoint inhibitors</a></div> <div> <span class="journal-title">BRITISH JOURNAL OF PHARMACOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0007-1188">0007-1188</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1476-5381">1476-5381</a>)</span>: <span class="journal-volume">183</span> <span class="journal-issue">6</span> <span class="page"> pp 1271-1287 </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/bph.16405" target="_blank" href="https://doi.org/10.1111/bph.16405"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001232023400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001232023400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85194824208" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85194824208"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38803135" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38803135&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16405" target="_blank" href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16405"> Egyéb URL </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/85194824208?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/85194824208?origin=resultslist"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 8</span> | Független: 7 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt:&nbsp;6 | WoS/Scopus jelölt:&nbsp;8 | DOI jelölt:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34889417&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34889417</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (LP-2021-14), (RRF-2.3.1-21-2022-0000) </div> <div class="lastModified">Utolsó módosítás: 2026.02.19. 14:58 Pécsi Éva (MTMT Közp 2,3, admin) </div> <div class="lockedBy">Központi kezelésű 2025.02.03. 21:57 Vándor Andrea (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Online kiadás 2024</pre> </div></div>