@article{MTMT:35154279,
	title = {Hydrophobic binary mixtures containing amphotericin B as lipophilic solutions for the treatment of cutaneous leishmaniasis},
	url = {https://m2.mtmt.hu/api/publication/35154279},
	author = {Augis, Luc and Nguyễn, Cảnh Hưng and Ciseran, Cécile and Wacha, András Ferenc and Mercier-Nomé, Françoise and Domenichini, Séverine and Sizun, Christina and Fourmentin, Sophie and Legrand, François-Xavier},
	doi = {10.1016/j.ijpharm.2024.124486},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {662},
	unique-id = {35154279},
	issn = {0378-5173},
	abstract = {Cutaneous leishmaniasis, caused by Leishmania parasites, requires treatments with fewer side effects than those currently available. The development of a topical solution based on amphotericin B (AmB) was pursued. The considerable interest in deep eutectic solvents (DESs) and their remarkable advantages inspired the search for a suitable hydrophobic excipient. Various mixtures based on commonly used hydrogen bond donors (HBDs) and acceptors (HBAs) for DES preparations were explored. Initial physical and in-vitro screenings showed the potential of quaternary phosphonium salt-based mixtures. Through thermal analysis, it was determined that most of these mixtures did not exhibit eutectic behavior. X-ray scattering studies revealed a sponge-like nanoscale structure. The most promising formulation, based on a combination of trihexyl(tetradecyl)phosphonium chloride and 1-oleoyl-rac-glycerol, showed no deleterious effects through histological evaluation. AmB was fully solubilized at concentrations between 0.5 and 0.8 mg·mL−1, depending on the formulation. The monomeric state of AmB was observed by circular dichroism. In-vitro irritation tests demonstrated acceptable viability for AmB-based formulations up to 0.5 mg·mL−1. Additionally, an ex-vivo penetration study on pig ear skin revealed no transcutaneous passage, confirming AmB retention in healthy, unaffected skin.},
	year = {2024},
	eissn = {1873-3476},
	orcid-numbers = {Augis, Luc/0009-0006-9847-0140; Wacha, András Ferenc/0000-0002-9609-0893; Sizun, Christina/0000-0002-5760-2614; Fourmentin, Sophie/0000-0002-4334-0051; Legrand, François-Xavier/0000-0002-7271-7284}
}

@article{MTMT:34263680,
	title = {Evaluation of In Vitro Antimicrobial Activity of Bioactive Compounds and the Effect of Allyl-Isothiocyanate on Chicken Meat Quality under Refrigerated Conditions},
	url = {https://m2.mtmt.hu/api/publication/34263680},
	author = {Hussein, Khabat Noori and Friedrich, Laszlo and Dalmadi, István and Kiskó, Gabriella},
	doi = {10.3390/app131910953},
	journal-iso = {APPL SCI-BASEL},
	journal = {APPLIED SCIENCES-BASEL},
	volume = {13},
	unique-id = {34263680},
	abstract = {Natural antimicrobials are effective against both food-borne pathogens and spoilage bacteria. The current study aimed to evaluate the in vitro antimicrobial activity of eight natural bioactive compounds (BACs) and one synthetic compound, butylated hydroxytoluene (BHT), and to evaluate the effect of one selected BAC (AITC) on the safety and quality of minced chicken meat. Additionally, physicochemical (pH, color, water-holding capacity (WHC), chemical forms of myoglobin (deoxymyoglobin-DeoMb, oxymyoglobin-OxyMb, and metmyoglobin-MetMb), thiobarbituric-acid-reactive substances (TBARs)), and microbiological properties (in vitro antimicrobial activity and determination of minimum inhibitory concentration (MIC)) were also evaluated through electronic-nose odor detection. Allyl-isothiocyanate (AITC), thymol, eugenol, and geraniol showed the broadest spectrum of in vitro antibacterial activity against one major meat spoilage bacterium and five pathogenic bacteria that were tested. Subsequently, AITC was selected to be applied to fresh minced chicken meat at different concentrations (at concentrations of the MIC (MIC-1), two times the MIC (MIC-2), and four times the MIC (MIC-4)). The chicken meat was then vacuum-packaged and kept for up to 14 days at 4 degrees C, and its quality properties were checked during storage. In this study, the addition of low concentrations of AITC (MIC-1) maintained the lightness (L*) and increased the WHC of the meat. High concentrations (MIC-2 and MIC-4) caused a significant increase in lightness (L*) and folded yellowness (b*) value, and they significantly reduced the redness (a*) and TBARS values compared to the control meat. The amounts of MetMb and DeoMb were reduced and the quantity of OxyMb was increased as a result of the addition of AITC to the chicken breast. Throughout storage, particularly at MIC-4, AITC showed the lowest numbers of aerobic mesophilic cells, as well as a reduction in Listeria monocytogenes cell numbers and a decrease in Salmonella Typhimurium counts. In addition, the meat containing MIC-4 did not exhibit growth of Pseudomonas lundensis after 10 days. During the storage period, an electronic-nose assay demonstrated a distinction in the odor buildup of AITC across the various meat groups, and meat treated with MIC-4 showed a trend that was clearly opposite to that of untreated meat. These encouraging results demonstrate the potential of AITC to improve the safety and shelf life of meat and meat products.},
	keywords = {antioxidant activity; ANTIMICROBIAL ACTIVITY; Bioactive compounds; PHYSICOCHEMICAL CHARACTERISTICS; Refrigerated storage; Shelf-Life Extension; Poultry meat; ALLYL-ISOTHIOCYANATE},
	year = {2023},
	eissn = {2076-3417}
}

@article{MTMT:32102464,
	title = {Effects of Glucosinolate-Derived Isothiocyanates on Fungi: A Comprehensive Review on Direct Effects, Mechanisms, Structure-Activity Relationship Data and Possible Agricultural Applications},
	url = {https://m2.mtmt.hu/api/publication/32102464},
	author = {Plaszkó, Tamás and Szűcs, Zsolt and Vasas, Gábor and Gonda, Sándor},
	doi = {10.3390/jof7070539},
	journal-iso = {J FUNGI},
	journal = {JOURNAL OF FUNGI},
	volume = {7},
	unique-id = {32102464},
	year = {2021},
	eissn = {2309-608X},
	pages = {539},
	orcid-numbers = {Plaszkó, Tamás/0000-0003-4211-3823; Gonda, Sándor/0000-0001-9776-0249}
}