@article{MTMT:33577682, title = {Predictors and long-term outcome of intracranial hemorrhage after thrombolytic therapy for acute ischemic stroke : A prospective single center study}, url = {https://m2.mtmt.hu/api/publication/33577682}, author = {Fekete, Klára and Héja, Máté and Márton, Sándor József and Tóth, Judit and Horváth, László and Harman, Aletta Andrea and Fekete, István}, doi = {10.3389/fneur.2023.1080046}, journal-iso = {FRONT NEUR}, journal = {FRONTIERS IN NEUROLOGY}, volume = {14}, unique-id = {33577682}, issn = {1664-2295}, abstract = {Introduction: Acute ischemic stroke (AIS) is a potentially devastating disease with high disability and mortality. Recombinant tissue plasminogen activator (rt-PA) is an effective treatment with a 2–8% possible risk for symptomatic intracranial hemorrhage (sICH). Our aim was to investigate the risk factors and long-term clinical outcomes of ICH in patients after rt-PA treatment. Methods: Consecutive patients with AIS, thrombolysed at the Department of Neurology, University of Debrecen, between 1 January 2004 and 31 August 2016 were enrolled prospectively. Risk factors, stroke severity based on the National Institute of Health Stroke Scale (NIHSS), functional outcome using the modified Rankin scale, and mortality at 1 year were compared in patients with and without ICH following rt-PA treatment. We evaluated clinical characteristics and prognosis by hemorrhage type based on the Heidelberg Bleeding Classification. Descriptive statistics, the chi-square test, the Mann–Whitney U-test, ANOVA, the Kruskal–Wallis test, a survival analysis, and logistic regression were performed as appropriate. Results: Out of 1,252 patients with thrombolysis, ICH developed in 138 patients, with 37 (2.95%) being symptomatic. Mean ages in the ICH and non-ICH groups differed significantly (p = 0.041). On admission, the 24-h NIHSS after thrombolysis was higher in patients with ICH (p < 0.0001). Large vessel occlusion was more prevalent in patients with ICH (p = 0.0095). The ICH risk was lower after intravenous thrombolysis than intra-arterial or combined thrombolysis (p < 0.0001). Both at 3 months and 1 year, the outcome was worse in patients with ICH compared to patients without ICH group (p < 0.0001). Mortality and poor outcome were more prevalent in all hemorrhage types with a tendency for massive bleeding associated with unfavorable prognosis. At 3 months with the logistic regression model, the worse outcome was detected in patients with ICH after thrombolysis, at 1 year in patients with ICH after thrombolysis and smoking. Discussion: Older age, higher NIHSS, large vessel occlusion, and intra-arterial thrombolysis may correlate with ICH. The unfavorable outcome is more common in patients with ICH. Precise scoring of post-thrombolysis bleeding might be a useful tool in the evaluation of the patient's prognosis. Our findings may help to identify predictors and estimate the prognosis of ICH in patients with AIS treated with rt-PA. Copyright © 2023}, year = {2023}, eissn = {1664-2295}, orcid-numbers = {Horváth, László/0000-0003-1466-7052} } @article{MTMT:32150787, title = {Impact of COVID-19 on ischemic stroke care in Hungary.}, url = {https://m2.mtmt.hu/api/publication/32150787}, author = {Böjti, Péter Pál and Szilágyi, Géza and Dobi, Balázs and Stang, Rita and Szikora, István and Kis, Balázs and Kornfeld, Ákos and Óváry, Csaba and Erőss, Loránd and Banczerowski, Péter and Kuczyński, Wojciech and Bereczki, Dániel}, doi = {10.1007/s11357-021-00424-z}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {43}, unique-id = {32150787}, issn = {2509-2715}, abstract = {Data about the coronavirus disease 2019 (COVID-19) pandemic's collateral damage on ischemic stroke (IS) care during the second epidemic wave in Central Europe are limited. We sought to evaluate the impact of the COVID-19 outbreak on Hungarian IS care during the two epidemic waves. This retrospective observational study was based on a nationwide reimbursement database that encompasses all IS admissions and all reperfusion interventions, i.e., intravenous thrombolysis (IVT) and endovascular therapy (EVT) from 2 January 2017 to 31 December 2020 in Hungary. COVID-19 pandemic's effect on the number of IS admissions and reperfusion interventions were analyzed using different statistics: means, medians, trends, relative rates, and linear relationships. The mean and median values of IS admissions and reperfusion interventions decreased only in some measure during the COVID-periods. However, trend analysis demonstrated a significant decline from the trends. The decline's dynamic and amplitude have differed for each variable. In contrast to IVT, the number of IS admissions and EVTs negatively correlated with the epidemic waves' amplitude. Besides, the decrease in the number of IS admissions was more pronounced than the decrease in the number of reperfusion interventions. Our study demonstrated a significant disruption in IS care during the COVID-19 epidemic in Hungary, in which multiple different factors might play a role. The disproportionate reduction of IS admission numbers could partially be explained by the effect of health emergency operative measures and changes in patients' social behavior. Further studies are needed to evaluate the causes of our observations.}, keywords = {Hungary; EPIDEMIOLOGY; thrombolysis; stroke; Thrombectomy; COVID-19}, year = {2021}, eissn = {2509-2723}, pages = {2231-2248}, orcid-numbers = {Böjti, Péter Pál/0000-0002-3065-5775; Stang, Rita/0000-0003-3093-9484; Szikora, István/0000-0003-3730-3278; Erőss, Loránd/0000-0002-5796-5546; Banczerowski, Péter/0000-0003-2144-5298; Bereczki, Dániel/0000-0002-8374-0500} } @article{MTMT:32196282, title = {Experiences With Intravenous Thrombolysis in Acute Ischemic Stroke by Elderly Patients–A “Real World Scenario”}, url = {https://m2.mtmt.hu/api/publication/32196282}, author = {Héja, Máté and Fekete, István and Horváth, László and Márton, Sándor József and Fekete, Klára}, doi = {10.3389/fneur.2021.721337}, journal-iso = {FRONT NEUR}, journal = {FRONTIERS IN NEUROLOGY}, volume = {12}, unique-id = {32196282}, issn = {1664-2295}, abstract = {Objectives: This retrospective single-center study aimed to investigate the risk factors, outcomes and complication rates in patients older vs. younger than 80 years treated with intravenous alteplase. Methods: Data of 1,253 thrombolysed patients were analyzed between January 1, 2004 and August 31, 2016. Vascular risk factors, stroke severity based on the NIHSS score, functional outcome using modified Rankin Scale (mRS), mortality and symptomatic intracerebral hemorrhage (SICH) were compared between two subgroups (<80 and >= 80 years). Results: 1,125 patients were included, 199 (17.6%) among them were aged over 80 years, majority (63.3%) were female (p < 0.00001). Mean age was 68.2 +/- 12.4 years, i.e., 64.7 +/- 10.8 years and 84.3 +/- 3.4 years in the younger and the older groups, respectively (p < 0.001). Atrial fibrillation and pre-stroke anticoagulation among patients over 80 years was more likely (p < 0.0005 and p = 0.02, respectively). NIHSS scores on admission and at 24 h were higher in elderly patients (p < 0.0001). ASPECT score at 24 h was less favorable in elderly patients (p = 0.007) and was associated with worse outcome. At 3 months, 59.8% of the patients from the older group had an unfavorable outcome (p < 0.0001), however 34.7% had independent outcome. The one-year- survival was significantly worse in the older group (p < 0.0001). The incidence of SICH was lower among older patients. In a logistic regression model, atrial fibrillation, heart failure, diabetes mellitus and smoking were proven as a significant independent risk factors for worse outcome. Conclusion: Although, the outcomes were less favorable in patients over 80 years of age, our results support the feasibility of using intravenous thrombolysis among patients over 80 years of age.}, keywords = {thrombolysis; ischemic stroke; outcome; elderly; Symptomatic intracerebral hemorrhage}, year = {2021}, eissn = {1664-2295}, orcid-numbers = {Horváth, László/0000-0003-1466-7052} } @article{MTMT:31936770, title = {Global Impact of COVID-19 on Stroke Care and IV Thrombolysis}, url = {https://m2.mtmt.hu/api/publication/31936770}, author = {Nogueira, Raul G and Qureshi, Muhammed M and Abdalkader, Mohamad and Martins, Sheila Ouriques and Yamagami, Hiroshi and Qiu, Zhongming and Mansour, Ossama Yassin and Sathya, Anvitha and Czlonkowska, Anna and Tsivgoulis, Georgios and Aguiar de Sousa, Diana and Demeestere, Jelle and Mikulik, Robert and Vanacker, Peter and Siegler, James E and Kõrv, Janika and Biller, Jose and Liang, Conrad W and Sangha, Navdeep S and Zha, Alicia M and Czap, Alexandra L and Holmstedt, Christine Anne and Turan, Tanya N and Ntaios, George and Malhotra, Konark and Tayal, Ashis and Loochtan, Aaron and Ranta, Annamarei and Mistry, Eva A and Alexandrov, Anne W and Huang, David Y and Yaghi, Shadi and Raz, Eytan and Sheth, Sunil A and Mohammaden, Mahmoud H and Frankel, Michael and Bila Lamou, Eric Guemekane and Aref, Hany M and Elbassiouny, Ahmed and Hassan, Farouk and Menecie, Tarek and Mustafa, Wessam and Shokri, Hossam M and Roushdy, Tamer and Sarfo, Fred S and Alabi, Tolulope Oyetunde and Arabambi, Babawale and Nwazor, Ernest O and Sunmonu, Taofiki Ajao and Wahab, Kolawole and Yaria, Joseph and Mohammed, Haytham Hussein and Adebayo, Philip B and Riahi, Anis D and Ben Sassi, Samia and Gwaunza, Lenon and Ngwende, Gift Wilson and Sahakyan, David and Rahman, Aminur and Ai, Zhibing and Bai, Fanghui and Duan, Zhenhui and Hao, Yonggang and Huang, Wenguo and Li, Guangwen and Li, Wei and Liu, Ganzhe and Luo, Jun and Shang, Xianjin and Sui, Yi and Tian, Ling and Wen, Hongbin and Wu, Bo and Yan, Yuying and Yuan, Zhengzhou and Zhang, Hao and Zhang, Jun and Zhao, Wenlong and Zi, Wenjie and Leung, Thomas W and Chugh, Chandril and Huded, Vikram and Menon, Bindu and Pandian, Jeyaraj Durai and Sylaja, P N and Usman, Fritz Sumantri and Farhoudi, Mehdi and Hokmabadi, Elyar Sadeghi and Horev, Anat and Reznik, Anna and Hoffmann, Rotem Sivan and Ohara, Nobuyuki and Sakai, Nobuyuki and Watanabe, Daisuke and Yamamoto, Ryoo and Doijiri, Ryosuke and Tokuda, Naoki and Yamada, Takehiro and Terasaki, Tadashi and Yazawa, Yukako and Uwatoko, Takeshi and Dembo, Tomohisa and Shimizu, Hisao and Sugiura, Yuri and Miyashita, Fumio and Fukuda, Hiroki and Miyake, Kosuke and Shimbo, Junsuke and Sugimura, Yusuke and Yagita, Yoshiki and Takenobu, Yohei and Matsumaru, Yuji and Yamada, Satoshi and Kono, Ryuhei and Kanamaru, Takuya and Yamazaki, Hidekazu and Sakaguchi, Manabu and Todo, Kenichi and Yamamoto, Nobuaki and Sonoda, Kazutaka and Yoshida, Tomoko and Hashimoto, Hiroyuki and Nakahara, Ichiro and Kondybayeva, Aida and Faizullina, Kamila and Kamenova, Saltanat and Zhanuzakov, Murat and Baek, Jang-Hyun and Hwang, Yangha and Lee, Jin Soo and Lee, Si Baek and Moon, Jusun and Park, Hyungjong and Seo, Jung Hwa and Seo, Kwon-Duk and Sohn, Sung Il and Young, Chang Jun and Ahdab, Rechdi and Wan Zaidi, Wan Asyraf and Aziz, Zariah Abdul and Basri, Hamidon Bin and Chung, Law Wan and Ibrahim, Aznita Binti and Ibrahim, Khairul Azmi and Looi, Irene and Tan, Wee Yong and Yahya, Nafisah Wan and Groppa, Stanislav and Leahu, Pavel and Al Hashmi, Amal M and Imam, Yahia Zakaria and Akhtar, Naveed and Pineda-Franks, Maria Carissa and Co, Christian Oliver and Kandyba, Dmitriy and Alhazzani, Adel and Al-Jehani, Hosam and Tham, Carol Huilian and Mamauag, Marlie Jane and Venketasubramanian, Narayanaswamy and Chen, Chih-Hao and Tang, Sung-Chun and Churojana, Anchalee and Akil, Esref and Aykaç, Ozlem and Ozdemir, Atilla Ozcan and Giray, Semih and Hussain, Syed Irteza and John, Seby and Le Vu, Huynh and Tran, Anh Duc and Nguyen, Huy Hoang and Pham, Thong Nhu and Nguyen, Thang Huy and Nguyen, Trung Quoc and Gattringer, Thomas and Enzinger, Christian and Killer-Oberpfalzer, Monika and Bellante, Flavio and De Blauwe, Sofie and Vanhooren, Geert and De Raedt, Sylvie and Dusart, Anne and Lemmens, Robin and Ligot, Noemie and Rutgers, Matthieu Pierre and Yperzeele, Laetitia and Alexiev, Filip and Sakelarova, Teodora and Bedeković, Marina Roje and Budincevic, Hrvoje and Cindrić, Igor and Hucika, Zlatko and Ozretic, David and Saric, Majda Seferovic and Pfeifer, Frantiek and Karpowic, Igor and Cernik, David and Sramek, Martin and Skoda, Miroslav and Hlavacova, Helena and Klecka, Lukas and Koutny, Martin and Vaclavik, Daniel and Skoda, Ondrej and Fiksa, Jan and Hanelova, Katerina and Nevsimalova, Miroslava and Rezek, Robert and Prochazka, Petr and Krejstova, Gabriela and Neumann, Jiri and Vachova, Marta and Brzezanski, Henryk and Hlinovsky, David and Tenora, Dusan and Jura, Rene and Jurák, Lubomír and Novak, Jan and Novak, Ales and Topinka, Zdenek and Fibrich, Petr and Sobolova, Helena and Volny, Ondrej and Christensen, Hanne Krarup and Drenck, Nicolas and Iversen, Helle Klingenberg and Simonsen, Claus Z and Truelsen, Thomas Clement and Wienecke, Troels and Vibo, Riina and Gross-Paju, Katrin and Toomsoo, Toomas and Antsov, Katrin and Caparros, Francois and Cordonnier, Charlotte and Dan, Maria and Faucheux, Jean-Marc and Mechtouff, Laura and Eker, Omer and Lesaine, Emilie and Ondze, Basile and Peres, Roxane and Pico, Fernando and Piotin, Michel and Pop, Raoul and Rouanet, Francois and Gubeladze, Tatuli and Khinikadze, Mirza and Lobjanidze, Nino and Tsikaridze, Alexander and Nagel, Simon and Ringleb, Peter Arthur and Rosenkranz, Michael and Schmidt, Holger and Sedghi, Annahita and Siepmann, Timo and Szabo, Kristina and Thomalla, Götz and Palaiodimou, Lina and Sagris, Dimitrios and Kargiotis, Odysseas and Klivényi, Péter and Szapáry, László and Tárkányi, Gábor and Adami, Alessandro and Bandini, Fabio and Calabresi, Paolo and Frisullo, Giovanni and Renieri, Leonardo and Sangalli, Davide and Pirson, Anne V and Uyttenboogaart, Maarten and van den Wijngaard, Ido and Kristoffersen, Espen Saxhaug and Brola, Waldemar and Fudala, Małgorzata and Horoch-Lyszczarek, Ewa and Karlinski, Michal and Kazmierski, Radoslaw and Kram, Pawel and Rogoziewicz, Marcin and Kaczorowski, Rafal and Luchowski, Piotr and Sienkiewicz-Jarosz, Halina and Sobolewski, Piotr and Fryze, Waldemar and Wisniewska, Anna and Wiszniewska, Malgorzata and Ferreira, Patricia and Ferreira, Paulo and Fonseca, Luisa and Marto, João Pedro and Pinho E Melo, Teresa and Nunes, Ana Paiva and Rodrigues, Miguel and Cruz, Vítor Tedim and Falup-Pecurariu, Cristian and Krastev, Georgi and Mako, Miroslav and Alonso de Leciñana, María and Arenillas, Juan F and Ayo-Martin, Oscar and Culebras, Antonio Cruz and Tejedor, Exuperio Diez and Montaner, Joan and Pérez-Sánchez, Soledad and Tola Arribas, Miguel Angel and Vasquez, Alejandro Rodriguez and Mazya, Michael and Bernava, Gianmarco and Brehm, Alex and Machi, Paolo and Fischer, Urs and Gralla, Jan and Michel, Patrik L and Psychogios, Marios-Nikos and Strambo, Davide and Banerjee, Soma and Krishnan, Kailash and Kwan, Joseph and Butt, Asif and Catanese, Luciana and Demchuk, Andrew and Field, Thalia and Haynes, Jennifer and Hill, Michael D and Khosravani, Houman and Mackey, Ariane and Pikula, Aleksandra and Saposnik, Gustavo and Scott, Courtney Anne and Shoamanesh, Ashkan and Shuaib, Ashfaq and Yip, Samuel and Barboza, Miguel A and Barrientos, Jose Domingo and Portillo Rivera, Ligia Ibeth and Gongora-Rivera, Fernando and Novarro-Escudero, Nelson and Blanco, Anmylene and Abraham, Michael and Alsbrook, Diana and Altschul, Dorothea and Alvarado-Ortiz, Anthony J and Bach, Ivo and Badruddin, Aamir and Barazangi, Nobl and Brereton, Charmaine and Castonguay, Alicia and Chaturvedi, Seemant and Chaudhry, Saqib A and Choe, Hana and Choi, Jae H and Dharmadhikari, Sushrut and Desai, Kinjal and Devlin, Thomas G and Doss, Vinodh T and Edgell, Randall and Etherton, Mark and Farooqui, Mudassir and Frei, Don and Gandhi, Dheeraj and Grigoryan, Mikayel and Gupta, Rishi and Hassan, Ameer E and Helenius, Johanna and Kaliaev, Artem and Kaushal, Ritesh and Khandelwal, Priyank and Khawaja, Ayaz M and Khoury, Naim N and Kim, Benny S and Kleindorfer, Dawn O and Koyfman, Feliks and Lee, Vivien H and Leung, Lester Y and Linares, Guillermo and Linfante, Italo and Lutsep, Helmi L and Macdougall, Lisa and Male, Shailesh and Malik, Amer and Masoud, Hesham and McDermott, Molly and Mehta, Brijesh P and Min, Jiangyong and Mittal, Manoj and Morris, Jane G and Multani, Sumeet S and Nahab, Fadi and Nalleballe, Krishna and Nguyen, Claude B and Novakovic-White, Roberta and Ortega-Gutierrez, Santiago and Rahangdale, Rahul H and Ramakrishnan, Pankajavalli and Romero, Jose Rafael and Rost, Natalia and Rothstein, Aaron and Ruland, Sean and Shah, Ruchir and Sharma, Malveeka and Silver, Brian and Simmons, Marc and Singh, Abhishek and Starosciak, Amy K and Strasser, Sheryl L and Szeder, Viktor and Teleb, Mohamed and Tsai, Jenny P and Voetsch, Barbara and Balaguera, Oscar and Pujol Lereis, Virginia A and Luraschi, Adriana and Almeida, Marcele Schettini and Cardoso, Fabricio Buchdid and Conforto, Adriana and De Deus Silva, Leonardo and Giacomini, Luidia Varrone and Lima, Fabricio Oliveira and Longo, Alexandre L and Magalhães, Pedro Sc and Martins, Rodrigo Targa and Mont'alverne, Francisco and Mora Cuervo, Daissy Liliana and Rebello, Leticia Costa and Valler, Lenise and Zetola, Viviane Flumignan and Lavados, Pablo M and Navia, Victor and Olavarría, Verónica V and Almeida Toro, Juan Manuel and Ricardo Amaya, Pablo Felipe and Bayona, Hernan and Corredor-Quintero, Angel Basilio and Rivera Ordonez, Carlos Eduardo and Mantilla Barbosa, Diana Katherine and Lara, Osvaldo and Patiño, Mauricio R and Diaz Escobar, Luis Fernando and Dejesus Melgarejo Farina, Donoband Edson and Villamayor, Analia Cardozo and Zelaya Zarza, Adolfo Javier and Barrientos Iman, Danny Moises and Kadota, Liliana Rodriguez and Campbell, Bruce and Hankey, Graeme J and Hair, Casey and Kleinig, Timothy and Ma, Alice and Martins, Rodrigo Tomazini and Sahathevan, Ramesh and Thijs, Vincent and Salazar, Daniel and Yuan-Hao Wu, Teddy and Haussen, Diogo C and Liebeskind, David and Yavagal, Dileep and Jovin, Tudor G and Zaidat, Osama O and Nguyen, Thanh N}, doi = {10.1212/WNL.0000000000011885}, journal-iso = {NEUROLOGY}, journal = {NEUROLOGY}, volume = {96}, unique-id = {31936770}, issn = {0028-3878}, abstract = {The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods.We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases.There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95%CI, -11.7 to - 11.3, p<0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 11,570 procedures during the pandemic, representing a 13.2% (95%CI, -13.8 to -12.7, p<0.0001) drop. Interfacility IVT transfers decreased from 1,337 to 1,178, or an 11.9% decrease (95%CI, -13.7 to -10.3, p=0.001). Recovery of stroke hospitalization volume (9.5%, 95%CI 9.2-9.8, p<0.0001) was noted over the two later (May, June) versus the two earlier (March, April) pandemic months. There was a 1.48% stroke rate across 119,967 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.3% (1,722/52,026) of all stroke admissions.The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.}, year = {2021}, eissn = {1526-632X}, pages = {2824-2838}, orcid-numbers = {Klivényi, Péter/0000-0002-5389-3266} } @article{MTMT:32013029, title = {A hazai COVID–19-járványhullámok területi különbségei}, url = {https://m2.mtmt.hu/api/publication/32013029}, author = {Uzzoli, Annamária and Kovács, Sándor Zsolt and Páger, Balázs and Szabó, Tamás}, doi = {10.15196/TS610302}, journal-iso = {TERÜLETI STATISZTIKA}, journal = {TERÜLETI STATISZTIKA}, volume = {61}, unique-id = {32013029}, issn = {0018-7828}, year = {2021}, eissn = {2064-8251}, pages = {291-319}, orcid-numbers = {Uzzoli, Annamária/0000-0002-0484-1451; Kovács, Sándor Zsolt/0000-0001-6612-6296; Páger, Balázs/0000-0001-8061-1300; Szabó, Tamás/0009-0001-8576-0329} } @article{MTMT:31312965, title = {Az aneszteziológiai és intenzív ellátás kihívásai a COVID–19-fertőzéssel kapcsolatban. Gyakorlati ajánlás}, url = {https://m2.mtmt.hu/api/publication/31312965}, author = {Fülesdi, Béla and Sárkány, Péter and Szentkereszty, Zoltán and Gál, János}, doi = {10.1556/650.2020.31808}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {161}, unique-id = {31312965}, issn = {0030-6002}, abstract = {Due to the coronavirus epidemic, healthcare systems face growing challenges all around the world nowadays. These challenges are the most critical in the field of intensive treatment and anesthesiology. One of the most important prerequisites of effective critical care treatment is preserving the involved healthcare workers from the infection, by providing them with detailed practical advices on the preventive measures and treatment strategies. The aim of the present review is to summarize the most important related knowledge available from previous experiences. Orv Hetil. 2020; 161(17): 652–659.}, keywords = {intensive care; COVID-19; az egészségügyi dolgozók személyi védelme; coronavirus epidemy; intenzív terápia; koronavírus-járvány; personal protection of healthcare workers}, year = {2020}, eissn = {1788-6120}, pages = {652-659}, orcid-numbers = {Gál, János/0000-0001-9160-6478} } @article{MTMT:1239200, title = {Guidelines for management of ischaemic stroke and transient ischaemic attack 2008}, url = {https://m2.mtmt.hu/api/publication/1239200}, author = {ESO, Executive Committee and ESO, Writing Committee}, doi = {10.1159/000131083}, journal-iso = {CEREBROVASC DIS}, journal = {CEREBROVASCULAR DISEASES}, volume = {25}, unique-id = {1239200}, issn = {1015-9770}, abstract = {This article represents the update of the European Stroke Initiative Recommendations for Stroke Management. These guidelines cover both ischaemic stroke and transient ischaemic attacks, which are now considered to be a single entity. The article covers referral and emergency management, Stroke Unit service, diagnostics, primary and secondary prevention, general stroke treatment, specific treatment including acute management, management of complications, and rehabilitation.}, year = {2008}, eissn = {1421-9786}, pages = {457-507} }