https://m2.mtmt.hu/ hun 2026-03-09 16:33 true true 1 3 3 1 100 1 3 DESC publishedYear false ASC firstAuthor true ASC title true JournalArticle 32613311 VALIDATED true Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, 4012, Hungary Doctoral School of Molecular Medicine, University of Debrecen, Debrecen, 4012, Hungary Carlsbad Research Organization Ltd, Újrónafő, 9244, Hungary Department of Biochemistry, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, 6720, Hungary Department of Dental Physiology and Pharmacology, Faculty of Dentistry, University of Debrecen, Debrecen, 4012, Hungary Department of Basic Medical Sciences, Faculty of Dentistry, University of Debrecen, Debrecen, 4012, Hungary Export Date: 2 March 2023 Correspondence Address: Pál, B.; Department of Physiology, Hungary; email: pal.balazs@med.unideb.hu Chemicals/CAS: acyl coenzyme A desaturase, 9014-34-0; astaxanthin, 472-61-7; carbon dioxide, 124-38-9, 58561-67-4; fatty acid synthase, 9045-77-6; ketamine, 1867-66-9, 6740-88-1, 81771-21-3; xanthine dehydrogenase, 9054-84-6; xylazine, 23076-35-9, 7361-61-7; xanthophyll, 127-40-2, 52842-48-5; Anabolic Agents; astaxanthine; Xanthophylls Tradenames: calypsol, Richter, Hungary; sedaxylan, Eurovet, Netherlands Manufacturers: Richter, Hungary; Eurovet, Netherlands Funding details: AstaReal A1010 Funding details: TKP-2020-NKA-04 Funding details: 2020-4.1.1-TKP2020 Funding details: Magyar Tudományos Akadémia, MTA, EFOP-3.6.2-16-2017-00006, EFOP-3.6.3-VEKOP-16-2017-00009, TKP2020-IKA-04 Funding details: Debreceni Egyetem, DE Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, FK 134684, GINOP-2.3.2-15-2016-00040, GINOP-2.3.3.15-2016-00020, NKFIH-K115397, NKFIH-K138090, PD-128370 Funding text 1: Funding: This research was supported by the National Research, Development and Innovation Office of Hungary (grant numbers: GINOP-2.3.2-15-2016-00040 (MYOTeam), GINOP-2.3.3.15-2016-00020, NKFI FK 134684 (A.K.-P), NKFIH PD-128370 (M.S.), NKFIH-K115397 (P.N.), NKFIH-K138090 (N.S.)) and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (to A.K.-P.). This work was also supported by the project EFOP-3.6.3-VEKOP-16-2017-00009 (M.S.) and EFOP-3.6.2-16-2017-00006 (P.N.). Project no. TKP2020-IKA-04 was implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the 2020-4.1.1-TKP2020 funding scheme. Support was also obtained from the Thematic Excellence Program of the Ministry for Innovation and Technology in Hungary (TKP-2020-NKA-04), within the framework of the Space Sciences thematic program of the University of Debrecen. Funding text 2: This research was supported by the National Research, Development and Innovation Office of Hungary (grant numbers: GINOP-2.3.2-15-2016-00040 (MYOTeam), GINOP-2.3.3.15-2016-00020, NKFI FK 134684 (A.K.-P), NKFIH PD-128370 (M.S.), NKFIH-K115397 (P.N.), NKFIH-K138090 (N.S.)) and the J?nos Bolyai Research Scholarship of the Hungarian Academy of Sciences (to A.K.-P.). This work was also supported by the project EFOP-3.6.3-VEKOP-16-2017-00009 (M.S.) and EFOP-3.6.2-16-2017-00006 (P.N.). Project no. TKP2020-IKA-04 was implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the 2020-4.1.1-TKP2020 funding scheme. Support was also obtained from the Thematic Excellence Program of the Ministry for Innovation and Technology in Hungary (TKP-2020-NKA-04), within the framework of the Space Sciences thematic program of the University of Debrecen.Acknowledgments: The authors are indebted to ?va S?gi and Tamara L?vei for their excellent technical assistance. We are grateful to AstaReal Co., Ltd., (Nacka, Sweden) for providing astaxanthin (AstaReal A1010) for research purposes. 0 false 2026-01-16T07:13:05.364+0000 2023-12-05T14:56:31.465+0000 2022-01-24T13:18:03.054+0000 true 10066331 Vida Zsuzsa Ágnes /api/admin/10066331 Admin true 2023-12-05T14:56:32.082+0000 2023-12-05T14:56:32.082+0000 2023-04-05T08:32:08.859+0000 true 10003141 Aggod Zsuzsa /api/admin/10003141 Admin true 10003141 2023-08-22T10:38:23.238+0000 true 10014568 Vándor Andrea /api/admin/10014568 Admin true 10014568 Admin 10003141 /api/admin/10003141 Aggod Zsuzsa true 10003141 true 2023-04-05T14:14:47.709+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Gönczi, Mónika Astaxanthin Exerts Anabolic Effects via Pleiotropic Modulation of the Excitable Tissue true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 23 2 917 917 19 2022 Astaxanthin is a lipid-soluble carotenoid influencing lipid metabolism, body weight, and insulin sensitivity. We provide a systematic analysis of acute and chronic effects of astaxanthin on different organs. Changes by chronic astaxanthin feeding were analyzed on general metabolism, expression of regulatory proteins in the skeletal muscle, as well as changes of excitation and synaptic activity in the hypothalamic arcuate nucleus of mice. Acute responses were also tested on canine cardiac muscle and different neuronal populations of the hypothalamic arcuate nucleus in mice. Dietary astaxanthin significantly increased food intake. It also increased protein levels affecting glucose metabolism and fatty acid biosynthesis in skeletal muscle. Inhibitory inputs innervating neurons of the arcuate nucleus regulating metabolism and food intake were strengthened by both acute and chronic astaxanthin treatment. Astaxanthin moderately shortened cardiac action potentials, depressed their plateau potential, and reduced the maximal rate of depolarization. Based on its complex actions on metabolism and food intake, our data support the previous findings that astaxanthin is suitable for supplementing the diet of patients with disturbances in energy homeostasis. 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Keyword 7975 /api/keyword/7975 true 7975 true Keyword 15202 /api/keyword/15202 true 15202 true Keyword 1010981 /api/keyword/1010981 true 1010981 true Keyword 1029644 /api/keyword/1029644 true 1029644 true Keyword 1378316 /api/keyword/1378316 true 1378316 true Keyword 2229594 /api/keyword/2229594 true true Keyword 2373924 /api/keyword/2373924 true true SjrRating 11289558 /api/sjrrating/11289558 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 true 1604 true D1 DIRECT true true /api/publication/32613311 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10017512"><a href="/gui2/?type=authors&mode=browse&sel=10017512" target="_blank">Gönczi Mónika (<span class="authorship-author-name">Gönczi Mónika</span> <span class="authorAux-mtmt"> Sejtélettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071339"><a href="/gui2/?type=authors&mode=browse&sel=10071339" target="_blank">Csemer Andrea<sup>*</sup> (<span class="authorship-author-name">Csemer Andrea</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet; <span title="Debreceni Egyetem">DE</span>/<span title="Orvostudományi Doktori Tanács">ODT</span>/Molekuláris Orvostudomány Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071480"><a href="/gui2/?type=authors&mode=browse&sel=10071480" target="_blank">Szabó László (<span class="authorship-author-name">Szabó László</span> <span class="authorAux-mtmt"> élettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet; <span title="Debreceni Egyetem">DE</span>/<span title="Orvostudományi Doktori Tanács">ODT</span>/Molekuláris Orvostudomány Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027648"><a href="/gui2/?type=authors&mode=browse&sel=10027648" target="_blank">Sztretye Mónika (<span class="authorship-author-name">Sztretye Mónika</span> <span class="authorAux-mtmt"> Sejtélettan, biofizika</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037316"><a href="/gui2/?type=authors&mode=browse&sel=10037316" target="_blank">Fodor János (<span class="authorship-author-name">Fodor János</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049069"><a href="/gui2/?type=authors&mode=browse&sel=10049069" target="_blank">Pocsai Krisztina (<span class="authorship-author-name">Deák-Pocsai Krisztina</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029058"><a href="/gui2/?type=authors&mode=browse&sel=10029058" target="_blank">Szenthe Kálmán (<span class="authorship-author-name">Szenthe Kálmán</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028522"><a href="/gui2/?type=authors&mode=browse&sel=10028522" target="_blank">Keller-Pintér Anikó (<span class="authorship-author-name">Keller-Pintér Anikó</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058325"><a href="/gui2/?type=authors&mode=browse&sel=10058325" target="_blank">Köhler Zoltán Márton (<span class="authorship-author-name">Köhler Zoltán Márton</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10005920"><a href="/gui2/?type=authors&mode=browse&sel=10005920" target="_blank">Nánási Péter (<span class="authorship-author-name">Nánási Péter Pál</span> <span class="authorAux-mtmt"> Élettan és kórélettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/Fogorvostudományi Kar; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019012"><a href="/gui2/?type=authors&mode=browse&sel=10019012" target="_blank">Szentandrássy Norbert (<span class="authorship-author-name">Szentandrássy Norbert</span> <span class="authorAux-mtmt"> élettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/Fogorvostudományi Kar; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017555"><a href="/gui2/?type=authors&mode=browse&sel=10017555" target="_blank">Pál Balázs ✉ (<span class="authorship-author-name">Pál Balázs Zoltán</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10007388"><a href="/gui2/?type=authors&mode=browse&sel=10007388" target="_blank">Csernoch László (<span class="authorship-author-name">Csernoch László</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32613311" target="_blank">Astaxanthin Exerts Anabolic Effects via Pleiotropic Modulation of the Excitable Tissue</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">23</span> <span class="journal-issue">2</span> <span class="page"> Paper 917. 19 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms23020917" target="_blank" href="https://doi.org/10.3390/ijms23020917"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000757677800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000757677800001"> WoS </a> </span> <span 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</span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 2 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32613311&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32613311</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Bibtex</span> </div> <div class="funder"> Szív és vázizom kutatások az alkalmazkodás , regeneráció és teljesítőképesség javítása érdekében ...(GINOP-2.3.2-15-2016-00040) Támogató: GINOP, Bioanalitikai műszerpark fehérjeszintű gyógyszerjelöltek molekuláris és sejtszintű vizsgálataihoz(GINOP-2.3.3-15-2016-00020) Támogató: GINOP, Nanoléptékű változások, nanoméretű vezikulák és nanotechnológiai megközelítések a vázizom regener...(FK 134684) Támogató: NKFIH, Karotinoidok, mint a biológiai mediátorok, amelyek a fokozott vázizomfunkcióért felelősek(PD 128370) Támogató: NKFIH, Adaptív és maladaptív jelátviteli mechanizmusok vizsgálata humán és emlôs szívben és agyszövetben(K 138090) Támogató: NKFIH, Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP, EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Támogató: NKFIH, Big Data, Biotechnológia, Energetika, Terápiás célú fejlesztés, Vízzel kapcsolatos kutatások és a...(TKP2020-IKA-04) Támogató: ITM, Thematic Excellence Program (Semmelweis University)(2020-4.1.1.-TKP2020) Támogató: Innovációs és Technológiai Minisztérium, DE-SPACE(TKP2020-NKA-04) Támogató: ITM, EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2023.12.05. 15:56 Wolf György (MTMT Központi admin) </div> <div class="lockedBy">Központi kezelésű 2023.04.05. 16:14 Aggod Zsuzsa (MTMT 2-3, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, 4012, Hungary Doctoral School of Molecular Medicine, University of Debrecen, Debrecen, 4012, Hungary Carlsbad Research Organization Ltd, Újrónafő, 9244, Hungary Department of Biochemistry, Albert Szent-Györgyi Medical School, University of Szeg...</pre> </div></div> JournalArticle 31145381 VALIDATED true 0 false 2026-03-05T11:39:45.547+0000 2025-02-17T15:22:32.099+0000 2020-01-28T15:31:37.759+0000 true 10066331 Vida Zsuzsa Ágnes /api/admin/10066331 Admin true 2025-02-17T15:22:32.587+0000 2025-02-17T15:22:32.587+0000 2020-08-26T19:41:46.547+0000 true 565 WoS import /api/admin/565 Admin true Admin 10073918 /api/admin/10073918 Kovács Marcell true true 2025-02-11T09:14:17.303+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Sztretye, Mónika Improved Tetanic Force and Mitochondrial Calcium Homeostasis by Astaxanthin Treatment in Mouse Skeletal Muscle true true /api/journal/10052535 REVIEWED true false 10052535 false 10052535 true 2076-3921 Journal FOREIGN 9 2 98 98 17 2020 Background: Astaxanthin (AX) a marine carotenoid is a powerful natural antioxidant which protects against oxidative stress and improves muscle performance. Retinol and its derivatives were described to affect lipid and energy metabolism. Up to date, the effects of AX and retinol on excitation-contraction coupling (ECC) in skeletal muscle are poorly described. Methods: 18 C57Bl6 mice were divided into two groups: Control and AX supplemented in rodent chow for 4 weeks (AstaReal A1010). In vivo and in vitro force and intracellular calcium homeostasis was studied. In some experiments acute treatment with retinol was employed. Results: The voltage activation of calcium transients (V50) were investigated in single flexor digitorum brevis isolated fibers under patch clamp and no significant changes were found following AX supplementation. Retinol shifted V50 towards more positive values and decreased the peak F/F0 of the calcium transients. The amplitude of tetani in the extensor digitorum longus was significantly higher in AX than in control group. Lastly, the mitochondrial calcium uptake was found to be less prominent in AX. Conclusion: AX supplementation increases in vitro tetanic force without affecting ECC and exerts a protecting effect on the mitochondria. Retinol treatment has an inhibitory effect on ECC in skeletal muscle. 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Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10027648"><a href="/gui2/?type=authors&mode=browse&sel=10027648" target="_blank">Sztretye Mónika (<span class="authorship-author-name">Sztretye Mónika</span> <span class="authorAux-mtmt"> Sejtélettan, biofizika</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071494"><a href="/gui2/?type=authors&mode=browse&sel=10071494" target="_blank">Singlár Zoltán (<span class="authorship-author-name">Singlár Zoltán</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071480"><a href="/gui2/?type=authors&mode=browse&sel=10071480" target="_blank">Szabó László (<span class="authorship-author-name">Szabó László</span> <span class="authorAux-mtmt"> élettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053966"><a href="/gui2/?type=authors&mode=browse&sel=10053966" target="_blank">Angyal Ágnes (<span class="authorship-author-name">Angyal Ágnes</span> <span class="authorAux-mtmt"> Molekuláris biológia, élettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038228"><a href="/gui2/?type=authors&mode=browse&sel=10038228" target="_blank">Balogh Norbert (<span class="authorship-author-name">Balogh Norbert</span> <span class="authorAux-mtmt"> Elméleti orvostudományok, DE ÁOK Élettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vakilzadeh Faranak </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010458"><a href="/gui2/?type=authors&mode=browse&sel=10010458" target="_blank">Szentesi Péter (<span class="authorship-author-name">Szentesi Péter</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018612"><a href="/gui2/?type=authors&mode=browse&sel=10018612" target="_blank">Dienes Beatrix (<span class="authorship-author-name">Dienes Beatrix</span> <span class="authorAux-mtmt"> Részecskefizika, Élettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10007388"><a href="/gui2/?type=authors&mode=browse&sel=10007388" target="_blank">Csernoch László ✉ (<span class="authorship-author-name">Csernoch László</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31145381" target="_blank">Improved Tetanic Force and Mitochondrial Calcium Homeostasis by Astaxanthin Treatment in Mouse Skeletal Muscle</a></div> <div> <span class="journal-title">ANTIOXIDANTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2076-3921">2076-3921</a>)</span>: <span class="journal-volume">9</span> <span class="journal-issue">2</span> <span class="page"> Paper 98. 17 p. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/antiox9020098" target="_blank" href="https://doi.org/10.3390/antiox9020098"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000519877100052" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000519877100052"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="278749" target="_blank" href="http://hdl.handle.net/2437/278749"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85078738942" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85078738942"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31979219" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31979219&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Clinical Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 22</span> | Független: 13 | Függő: 9 | Nem jelölt: 0 | WoS jelölt: 16 | Scopus jelölt:&nbsp;16 | WoS/Scopus jelölt:&nbsp;17 | DOI jelölt:&nbsp;20 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31145381&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31145381</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> „Felsőoktatási Intézményi Kiválósági Program - 4. Vízzel kapcsolatos kutatások” tématerület(NKFIH-1150-6/2019) Támogató: NKFIH, Karotinoidok, mint a biológiai mediátorok, amelyek a fokozott vázizomfunkcióért felelősek(PD 128370) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2025.02.17. 16:22 Kovács Marcell (MTMT Közp., admin) </div> <div class="lockedBy">Központi kezelésű 2025.02.11. 10:14 Kovács Marcell (MTMT Közp., admin) </div> </div></div> JournalArticle 30814023 VALIDATED true A real.mtak-ról letölhető pdf neve (Astaxanthinreview_revised_2019.pdf) alapján az ott található egy revised változat, melynek bibliográfiai leírása eltér az újságban megjelent, hivatalos változat leírásától. A leírásban eltérések: A hivatalos megjelenés (a folyóirat) szerint a pontos cím: "Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging", míg az real.mtak leírása szerint a pontos cím: "Astaxanthin, a potential mitochondrial targeted antioxidant treatment in diseases and with aging". A real.mtak szerinti leírás, a revised változat szerint a 200.kötetben a 1-28. oldalon található, a hivatalos megjelenés (a folyóirat) szerint a 2019. évi kötetben a 14 oldalas terjedelemben található. Továbbá az absztraktban is található egy minimális eltérés ( pl.: a revised változatban prooxidant helyett pro-oxidant szerepel, vagy az and helyett as well as szerepel a mondatban, stb.). 0 false 2026-03-09T08:12:00.665+0000 2025-02-17T15:17:29.911+0000 2019-09-24T08:39:08.087+0000 true 10027648 Sztretye Mónika /api/author/10027648 Author true 10027648 2025-02-17T15:17:05.373+0000 2025-02-17T15:17:05.373+0000 2025-02-17T15:17:30.095+0000 true 10073918 Kovács Marcell /api/admin/10073918 Admin true Admin 10073918 /api/admin/10073918 Kovács Marcell true true 2025-02-11T09:14:17.303+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Sztretye, M Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging true true /api/journal/10011773 REVIEWED true false 10011773 false 10011773 true 1942-0900 1942-0994 Journal FOREIGN 2019 3849692 3849692 14 2019 Oxidative stress is characterized by an imbalance between prooxidant and antioxidant species, leading to macromolecular damage and disruption of redox signaling and cellular control. It is a hallmark of various diseases including metabolic syndrome, chronic fatigue syndrome, neurodegenerative, cardiovascular, inflammatory, and age-related diseases. Several mitochondrial defects have been considered to contribute to the development of oxidative stress and known as the major mediators of the aging process and subsequent age-associated diseases. Thus, mitochondrial-targeted antioxidants should prevent or slow down these processes and prolong longevity. This is the reason why antioxidant treatments are extensively studied and newer and newer compounds with such an effect appear. Astaxanthin, a xanthophyll carotenoid, is the most abundant carotenoid in marine organisms and is one of the most powerful natural compounds with remarkable antioxidant activity. Here, we summarize its antioxidant targets, effects, and benefits in diseases and with aging. 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ClassificationExternal 1303 /api/classificationexternal/1303 true 1303 true Q1 DIRECT true true /api/publication/30814023 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10027648"><a href="/gui2/?type=authors&mode=browse&sel=10027648" target="_blank">Sztretye M (<span class="authorship-author-name">Sztretye Mónika</span> <span class="authorAux-mtmt"> Sejtélettan, biofizika</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018612"><a href="/gui2/?type=authors&mode=browse&sel=10018612" target="_blank">Dienes B (<span class="authorship-author-name">Dienes Beatrix</span> <span class="authorAux-mtmt"> Részecskefizika, Élettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017512"><a href="/gui2/?type=authors&mode=browse&sel=10017512" target="_blank">Gönczi M (<span class="authorship-author-name">Gönczi Mónika</span> <span class="authorAux-mtmt"> Sejtélettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054704"><a href="/gui2/?type=authors&mode=browse&sel=10054704" target="_blank">Czirják T (<span class="authorship-author-name">Czirják Tamás</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10007388"><a href="/gui2/?type=authors&mode=browse&sel=10007388" target="_blank">Csernoch L (<span class="authorship-author-name">Csernoch László</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002420"><a href="/gui2/?type=authors&mode=browse&sel=10002420" target="_blank">Dux L (<span class="authorship-author-name">Dux László</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010458"><a 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Aging</a></div> <div> <span class="journal-title">OXIDATIVE MEDICINE AND CELLULAR LONGEVITY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1942-0900">1942-0900</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1942-0994">1942-0994</a>)</span>: <span class="journal-volume">2019</span> <span class="page"> Paper 3849692. 14 p. </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1155/2019/3849692" target="_blank" href="https://doi.org/10.1155/2019/3849692"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="100883" target="_blank" href="http://real.mtak.hu/100883"> REAL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" 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jelölt:&nbsp;193 | DOI jelölt:&nbsp;211 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30814023&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30814023</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Támogató: NKFIH, Szív és vázizom kutatások az alkalmazkodás , regeneráció és teljesítőképesség javítása érdekében ...(GINOP-2.3.2-15-2016-00040) Támogató: GINOP, Intracelluláris raktárak által vezérelt kalciumbelépés módosulásának szerepe a vázizmok kalciumho...(K-115461) Támogató: NKFIH, Karotinoidok, mint a biológiai mediátorok, amelyek a fokozott vázizomfunkcióért felelősek(PD 128370) Támogató: NKFIH, A mitokondriumok és a raktár által vezérelt kalciumbelépés szerepének vizsgálata egészséges és kó...(ÚNKP-18-4-DE-157) Támogató: NKFIH, Felsőoktatási intézményi kiválósági program (FIKP)(20428-3/2018/FEKUTSTRAT) Támogató: Emberi Erőforrások Minisztériuma, Bolyai+ Felsőoktatási Fiatal Oktatói, Kutatói Ösztöndíj Keller-Pintér Anikó számára(ÚNKP-19-4-SZTE-23) Támogató: ÚNKP </div> <div class="notDuplums"><a target="_blank" href="/api/publication/30814023/notduplums">8 Nem duplumnak jelölés</a> </div> <div class="lastModified">Utolsó módosítás: 2025.02.17. 16:17 Kovács Marcell (MTMT Közp., admin) </div> <div class="lockedBy">Központi kezelésű 2025.02.11. 10:14 Kovács Marcell (MTMT Közp., admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: A real.mtak-ról letölhető pdf neve (Astaxanthinreview_revised_2019.pdf) alapján az ott található egy revised változat, melynek bibliográfiai leírása eltér az újságban megjelent, hivatalos változat leírásától. A leírásban eltérések: A hivatalos megjelenés (a folyóirat) szerint a pontos cím: "Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging", míg az...</pre> </div></div>