TY - JOUR AU - Ungár Tamás Lászlóné Polyák, Éva AU - Müller, Henriett AU - Figler, Mária AU - Sütő, Gábor AU - Herman, Veronika AU - Breitenbach, Zita TI - Étrendi tényezők és tápanyagok szerepe rheumatoid arthritisben JF - ORVOSI HETILAP J2 - ORV HETIL VL - 164 PY - 2023 IS - 27 SP - 1052 EP - 1061 PG - 10 SN - 0030-6002 DO - 10.1556/650.2023.32797 UR - https://m2.mtmt.hu/api/publication/33948430 ID - 33948430 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Zöld, Éva AU - Szodoray, P AU - Kappelmayer, János AU - Gaál, János AU - Csáthy, László AU - Baráth, Sándor AU - Gyimesi, Edit AU - Hajas, Ágota AU - Zeher, Margit AU - Szegedi, Gyula AU - Bodolay, Edit TI - Impaired regulatory T-cell homeostasis due to vitamin D deficiency in undifferentiated connective tissue disease JF - SCANDINAVIAN JOURNAL OF RHEUMATOLOGY J2 - SCAND J RHEUMATOL VL - 39 PY - 2010 IS - 6 SP - 490 EP - 497 PG - 8 SN - 0300-9742 DO - 10.3109/03009741003781951 UR - https://m2.mtmt.hu/api/publication/1472409 ID - 1472409 AB - Objective: The aim of this study was to perform a quantitative and functional analysis of natural CD4+CD25highFoxp3+ regulatory T cells (nTregs) and CD4+IL-17+ T cells, and to assess the serum levels of proinflammatory cytokines in patients with undifferentiated connective tissue disease (UCTD) before and after 5 weeks of 0.5 μg/day alfacalcidol supplementation. Methods: Twenty-five patients with UCTD were enrolled in an open-label trial of alfacalcidol. Plasma levels of 25-hydroxyvitamin D [25(OH)D] were assessed by a high-performance liquid chromatography (HPLC) method. Flow cytometry was used for the quantification of nTregs and the IL-17 expression of T-helper (Th)17 cells. The serum concentrations of cytokines interleukin (IL)-12, interferon (IFN)-γ, IL-23, IL-17, IL-6, and IL-10 were measured by an enzyme-linked immunosorbent assay (ELISA). Results: Treatment with alfacalcidol raised 25(OH)D levels from a mean of 23.5 ± 5.6 to 34.5 ± 7.4 ng/mL (p = 0.059; NS). Alfacalcidol treatment decreased both Th1- (IL-12 and IFN-γ) and Th17-related (IL-23, IL-17, IL-6) cytokine levels in UCTD patients, while the soluble IL-10 level increased (IL-12: 156.7 ± 75.2 vs. 87.5 ± 42.1 pg/mL, p < 0.001; IFN-γ: 41.5 ± 12.0 vs. 21.7 ± 9.9 pg/mL, p < 0.001; IL-23: 385.2 ± 82.2 vs. 210.0 ± 69.3 pg/mL, p < 0.001; IL-17: 37.8 ± 9.6 vs. 17.8 ± 4.5 pg/mL, p 0.009; IL-6: 39.4 ± 11.3 vs. 23.5 ± 6.3 pg/mL, p < 0.001, IL-10: 8.4 ± 3.0 vs. 21.4 ± 9.7 pg/mL, p < 0.001). Alfacalcidol improved the Th17nTreg imbalance, as it inhibited the IL-17 expression of Th17 cells, and increased the number of nTregs. The alfacalcidol might increase the capacity of nTreg cells to suppress the proliferation of autologous CD4+CD25- cells. Conclusion: Our findings support the idea that vitamin D influences the Th17nTreg imbalance in vitamin D-insufficient patients with UCTD and could be beneficial in the management of the disease. © 2010 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation. LA - English DB - MTMT ER - TY - JOUR AU - Márton, Krisztina AU - Madléna, Melinda AU - Bánóczy, Jolán AU - Varga, Gábor AU - Fejérdy, Pál AU - Sreebny, LM AU - Nagy, Gábor TI - Unstimulated whole saliva flow rate in relation to sicca symptoms in Hungary JF - ORAL DISEASES J2 - ORAL DIS VL - 14 PY - 2008 IS - 5 SP - 472 EP - 477 PG - 6 SN - 1354-523X DO - 10.1111/j.1601-0825.2007.01404.x UR - https://m2.mtmt.hu/api/publication/1414109 ID - 1414109 N1 - Megjegyzés-21262498 PubMed ID: 18938274 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Emese AU - Dankó, Katalin AU - Sütő, Gábor AU - Zeher, Margit TI - A szisztémás autoimmun betegségek közös és eltérő sajátosságai JF - ORVOSI HETILAP J2 - ORV HETIL VL - 148 PY - 2007 IS - Suppl. 1 SP - 44 EP - 51 PG - 8 SN - 0030-6002 DO - 10.1556/OH.2007.28035 UR - https://m2.mtmt.hu/api/publication/1415131 ID - 1415131 AB - Systemic autoimmune disorders constitute a well-characterized and separate group of diseases in the field of clinical immunology and rheumatology. Despite their shared characteristics, these diseases have several distinctive features. The similarity and the difference are manifested both in etiology (i.e. the importance and ratio of genetic and environmental factors), in pathomechanism (i.e. the dominance of cellular or humoral immune response), in the disease outcome (fluctuating or chronic progressive) and in the diversity of clinical manifestations (i.e. multiple organ involvements or some dominant target organs/tissues). In the present work the authors describe the features of four prototypic autoimmune disorders - systemic lupus erythematosus, Sjogren's disease, dermato-polymyositis and systemic sclerosis - and characterise in general the common and particular specific points of systemic autoimmune disorders focusing on the variability and subgroups which can be observed even within certain diseases. LA - Hungarian DB - MTMT ER -