@article{MTMT:33948430, title = {Étrendi tényezők és tápanyagok szerepe rheumatoid arthritisben}, url = {https://m2.mtmt.hu/api/publication/33948430}, author = {Ungár Tamás Lászlóné Polyák, Éva and Müller, Henriett and Figler, Mária and Sütő, Gábor and Herman, Veronika and Breitenbach, Zita}, doi = {10.1556/650.2023.32797}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {164}, unique-id = {33948430}, issn = {0030-6002}, year = {2023}, eissn = {1788-6120}, pages = {1052-1061}, orcid-numbers = {Ungár Tamás Lászlóné Polyák, Éva/0000-0002-3648-1614; Breitenbach, Zita/0000-0002-9744-4665} } @article{MTMT:1472409, title = {Impaired regulatory T-cell homeostasis due to vitamin D deficiency in undifferentiated connective tissue disease}, url = {https://m2.mtmt.hu/api/publication/1472409}, author = {Zöld, Éva and Szodoray, P and Kappelmayer, János and Gaál, János and Csáthy, László and Baráth, Sándor and Gyimesi, Edit and Hajas, Ágota and Zeher, Margit and Szegedi, Gyula and Bodolay, Edit}, doi = {10.3109/03009741003781951}, journal-iso = {SCAND J RHEUMATOL}, journal = {SCANDINAVIAN JOURNAL OF RHEUMATOLOGY}, volume = {39}, unique-id = {1472409}, issn = {0300-9742}, abstract = {Objective: The aim of this study was to perform a quantitative and functional analysis of natural CD4+CD25highFoxp3+ regulatory T cells (nTregs) and CD4+IL-17+ T cells, and to assess the serum levels of proinflammatory cytokines in patients with undifferentiated connective tissue disease (UCTD) before and after 5 weeks of 0.5 μg/day alfacalcidol supplementation. Methods: Twenty-five patients with UCTD were enrolled in an open-label trial of alfacalcidol. Plasma levels of 25-hydroxyvitamin D [25(OH)D] were assessed by a high-performance liquid chromatography (HPLC) method. Flow cytometry was used for the quantification of nTregs and the IL-17 expression of T-helper (Th)17 cells. The serum concentrations of cytokines interleukin (IL)-12, interferon (IFN)-γ, IL-23, IL-17, IL-6, and IL-10 were measured by an enzyme-linked immunosorbent assay (ELISA). Results: Treatment with alfacalcidol raised 25(OH)D levels from a mean of 23.5 ± 5.6 to 34.5 ± 7.4 ng/mL (p = 0.059; NS). Alfacalcidol treatment decreased both Th1- (IL-12 and IFN-γ) and Th17-related (IL-23, IL-17, IL-6) cytokine levels in UCTD patients, while the soluble IL-10 level increased (IL-12: 156.7 ± 75.2 vs. 87.5 ± 42.1 pg/mL, p < 0.001; IFN-γ: 41.5 ± 12.0 vs. 21.7 ± 9.9 pg/mL, p < 0.001; IL-23: 385.2 ± 82.2 vs. 210.0 ± 69.3 pg/mL, p < 0.001; IL-17: 37.8 ± 9.6 vs. 17.8 ± 4.5 pg/mL, p 0.009; IL-6: 39.4 ± 11.3 vs. 23.5 ± 6.3 pg/mL, p < 0.001, IL-10: 8.4 ± 3.0 vs. 21.4 ± 9.7 pg/mL, p < 0.001). Alfacalcidol improved the Th17nTreg imbalance, as it inhibited the IL-17 expression of Th17 cells, and increased the number of nTregs. The alfacalcidol might increase the capacity of nTreg cells to suppress the proliferation of autologous CD4+CD25- cells. Conclusion: Our findings support the idea that vitamin D influences the Th17nTreg imbalance in vitamin D-insufficient patients with UCTD and could be beneficial in the management of the disease. © 2010 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation.}, keywords = {Adult; Adolescent; Female; Male; ARTICLE; CYTOKINE PRODUCTION; cytokine; human; high performance liquid chromatography; priority journal; controlled study; enzyme linked immunosorbent assay; clinical article; clinical trial; Flow Cytometry; Homeostasis; protein blood level; antigen expression; interleukin 6; interleukin 10; gamma interferon; connective tissue disease; Th1 cell; regulatory T lymphocyte; interleukin 12; interleukin 23; 25 hydroxyvitamin D; vitamin D deficiency; Th17 cell; interleukin 17; alfacalcidol}, year = {2010}, eissn = {1502-7732}, pages = {490-497}, orcid-numbers = {Gaál, János/0000-0003-0462-1392} } @article{MTMT:1414109, title = {Unstimulated whole saliva flow rate in relation to sicca symptoms in Hungary}, url = {https://m2.mtmt.hu/api/publication/1414109}, author = {Márton, Krisztina and Madléna, Melinda and Bánóczy, Jolán and Varga, Gábor and Fejérdy, Pál and Sreebny, LM and Nagy, Gábor}, doi = {10.1111/j.1601-0825.2007.01404.x}, journal-iso = {ORAL DIS}, journal = {ORAL DISEASES}, volume = {14}, unique-id = {1414109}, issn = {1354-523X}, year = {2008}, eissn = {1601-0825}, pages = {472-477}, orcid-numbers = {Márton, Krisztina/0000-0002-6525-2511; Madléna, Melinda/0000-0002-2154-3069; Varga, Gábor/0000-0002-5506-8198; Fejérdy, Pál/0000-0002-1412-7462; Nagy, Gábor/0000-0001-5510-7903} } @article{MTMT:1415131, title = {A szisztémás autoimmun betegségek közös és eltérő sajátosságai}, url = {https://m2.mtmt.hu/api/publication/1415131}, author = {Kiss, Emese and Dankó, Katalin and Sütő, Gábor and Zeher, Margit}, doi = {10.1556/OH.2007.28035}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {148}, unique-id = {1415131}, issn = {0030-6002}, abstract = {Systemic autoimmune disorders constitute a well-characterized and separate group of diseases in the field of clinical immunology and rheumatology. Despite their shared characteristics, these diseases have several distinctive features. The similarity and the difference are manifested both in etiology (i.e. the importance and ratio of genetic and environmental factors), in pathomechanism (i.e. the dominance of cellular or humoral immune response), in the disease outcome (fluctuating or chronic progressive) and in the diversity of clinical manifestations (i.e. multiple organ involvements or some dominant target organs/tissues). In the present work the authors describe the features of four prototypic autoimmune disorders - systemic lupus erythematosus, Sjogren's disease, dermato-polymyositis and systemic sclerosis - and characterise in general the common and particular specific points of systemic autoimmune disorders focusing on the variability and subgroups which can be observed even within certain diseases.}, keywords = {Humans; Lupus Erythematosus, Systemic/*immunology; Scleroderma, Systemic/*immunology; Sjogren's Syndrome/*immunology; Dermatomyositis/*immunology}, year = {2007}, eissn = {1788-6120}, pages = {44-51}, orcid-numbers = {Kiss, Emese/0000-0002-5399-2379} }