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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31907087&dopt=Abstract false true SjrRating 10871478 /api/sjrrating/10871478 128 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2735 /api/classificationexternal/2735 true 2735 true Q2 DIRECT true true /api/publication/31122140 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10023716"><a href="/gui2/?type=authors&mode=browse&sel=10023716" target="_blank">Tarnoki Adam D. ✉ (<span class="authorship-author-name">Tárnoki Ádám Domonkos</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023718"><a href="/gui2/?type=authors&mode=browse&sel=10023718" target="_blank">Tarnoki David L. (<span class="authorship-author-name">Tárnoki Dávid László</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064574"><a href="/gui2/?type=authors&mode=browse&sel=10064574" target="_blank">Forgo Bianka (<span class="authorship-author-name">Forgó Bianka</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072148"><a href="/gui2/?type=authors&mode=browse&sel=10072148" target="_blank">Szabo Helga (<span class="authorship-author-name">Szabó Helga</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10046203"><a href="/gui2/?type=authors&mode=browse&sel=10046203" target="_blank">Melicher Dora (<span class="authorship-author-name">Melicher Dóra</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Genetikai, Sejt- és Immunbiológiai Intézet">GSII</span>/MTA-SE Immun-proteogenomikai Extracelluláris Vezikula Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Metneki Julia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10085171"><a href="/gui2/?type=authors&mode=browse&sel=10085171" target="_blank">Littvay Levente (<span class="authorship-author-name">Littvay Levente</span> <span class="authorAux-mtmt"> </span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31122140" target="_blank">The Hungarian Twin Registry Update: Turning From a Voluntary to a Population-Based Registry</a></div> <div> <span class="journal-title">TWIN RESEARCH AND HUMAN GENETICS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1832-4274">1832-4274</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1839-2628">1839-2628</a>)</span>: <span class="journal-volume">22</span> <span class="journal-issue">6</span> <span class="page"> pp 561-566 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1017/thg.2019.100" target="_blank" href="https://doi.org/10.1017/thg.2019.100"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="8190" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/8190"> SE Repozitórium </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="106145" target="_blank" href="http://real.mtak.hu/106145"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000517442200019" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000517442200019"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85077742661" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85077742661"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31907087" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31907087&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pediatrics, Perinatology and Child Health&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Obstetrics and Gynecology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Genetics (clinical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q4</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 24</span> | Független: 6 | Függő: 18 | Nem jelölt: 0 | WoS jelölt: 22 | Scopus jelölt:&nbsp;24 | WoS/Scopus jelölt:&nbsp;24 | DOI jelölt:&nbsp;23 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31122140&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31122140</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.02.05. 08:55 Pirmann Tamás (OOI addmin5, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Medical Imaging, Semmelweis University, Budapest, Hungary Hungarian Twin Registry Foundation, Budapest, Hungary Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary MTA-SE Immune-Proteogenomics Extracellular Vesicle Research Group, Budapest, Hungary ...</pre> </div></div> JournalArticle 35461286 VALIDATED true 0 false 2026-06-16T10:14:37.149+0000 2024-10-31T09:04:08.867+0000 2024-10-16T05:28:44.518+0000 true 10097449 Bodnár Barbara /api/admin/10097449 Admin true 2024-11-12T09:38:05.738+0000 2024-11-08T11:36:23.558+0000 true 569 Balázs András /api/admin/569 Admin true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2025-01-02T12:00:28.482+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Ling, H. Characteristics of progressive supranuclear palsy presenting with corticobasal syndrome a cortical variant true true /api/journal/3358 REVIEWED true false 3358 false 3358 true 0305-1846 1365-2990 Journal FOREIGN 40 2 149 163 149 15 2014 AimsSince the first description of the classical presentation of progressive supranuclear palsy (PSP) in 1963, now known as Richardson's syndrome (PSP-RS), several distinct clinical syndromes have been associated with PSP-tau pathology. Like other neurodegenerative disorders, the severity and distribution of phosphorylated tau pathology are closely associated with the clinical heterogeneity of PSP variants. PSP with corticobasal syndrome presentation (PSP-CBS) was reported to have more tau load in the mid-frontal and inferior-parietal cortices than in PSP-RS. However, it is uncertain if differences exist in the distribution of tau pathology in other brain regions or if the overall tau load is increased in the brains of PSP-CBS. MethodsWe sought to compare the clinical and pathological features of PSP-CBS and PSP-RS including quantitative assessment of tau load in 15 cortical, basal ganglia and cerebellar regions. ResultsIn addition to the similar age of onset and disease duration, we demonstrated that the overall severity of tau pathology was the same between PSP-CBS and PSP-RS. We identified that there was a shift of tau burden towards the cortical regions away from the basal ganglia; supporting the notion that PSP-CBS is a cortical' PSP variant. PSP-CBS also had less severe neuronal loss in the dorsolateral and ventrolateral subregions of the substantia nigra and more severe microglial response in the corticospinal tract than in PSP-RS; however, neuronal loss in subthalamic nucleus was equally severe in both groups. ConclusionsA better understanding of the factors that influence the selective pathological vulnerability in different PSP variants will provide further insights into the neurodegenerative process underlying tauopathies. 2024 true true true false false NONE 2026-06-16 false 78 0 78 67 1 78 78 78 67 78 78 67 67 67 11 0 78 67 78 67 0 10 10 D1 false false false false 2025-01-14T07:17:41.926+0000 1 1 0 10 0 true 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 120944545 /api/authorship/120944545 1 0.1 true false false Ling H. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944546 /api/authorship/120944546 2 0.1 false false false de Silva R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944547 /api/authorship/120944547 3 0.1 false false false Massey L. 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A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Courtney R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hondhamuni G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bajaj N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lowe J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Holton J. L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lees A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10097351"><a href="/gui2/?type=authors&mode=browse&sel=10097351" target="_blank">Revesz T. ✉ (<span class="authorship-author-name">Révész Tamás</span> <span class="authorAux-mtmt"> Neuropathológia - klinikai idegtudomány</span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35461286" target="_blank">Characteristics of progressive supranuclear palsy presenting with corticobasal syndrome : a cortical variant.</a></div> <div> <span class="journal-title">NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0305-1846">0305-1846</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1365-2990">1365-2990</a>)</span>: <span class="journal-volume">40</span> <span class="journal-issue">2</span> <span class="page"> pp 149-163 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/nan.12037" target="_blank" href="https://doi.org/10.1111/nan.12037"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000331059100006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000331059100006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84892667945" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84892667945"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="23432126" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23432126&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Histology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pathology and Forensic Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neurology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 78</span> | Független: 67 | Függő: 11 | Nem jelölt: 0 | WoS jelölt: 78 | Scopus jelölt:&nbsp;67 | WoS/Scopus jelölt:&nbsp;78 | DOI jelölt:&nbsp;78 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35461286&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35461286</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2024.10.31. 10:04 Bodnár Barbara (MTMT ellenőrzés admin5) </div> <div class="lockedBy">Központi kezelésű 2025.01.02. 13:00 Ladányi Gusztáv (MTMT API user, admin) </div> </div></div> JournalArticle 35461306 VALIDATED true 0 false 2026-06-14T23:06:43.343+0000 2024-10-31T06:19:25.263+0000 2024-10-16T05:29:27.036+0000 true 10097449 Bodnár Barbara /api/admin/10097449 Admin true 2024-11-12T09:21:05.927+0000 2024-11-11T13:04:34.379+0000 true 569 Balázs András /api/admin/569 Admin true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2025-01-02T12:00:28.482+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Massey, Luke A. Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy true true /api/journal/3283 REVIEWED true false 3283 false 3283 true 0885-3185 1531-8257 Journal FOREIGN 27 14 1755 1762 1755 8 2012 Conventional magnetic resonance imaging (cMRI) is often used to aid the diagnosis of progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), but its ability to predict the histopathological diagnosis has not been systematically studied. cMRI from 48 neuropathologically confirmed cases, including PSP (n = 22), MSA (n = 13), Parkinson's disease (PD) (n = 7), and corticobasal degeneration (n = 6), and controls (n = 9) were assessed blinded to clinical details and systematically rated for reported abnormalities. Clinical diagnosis and macroscopic postmortem findings were retrospectively assessed. Radiological assessment of MRI was correct in 16 of 22 (72.7%) PSP cases and 10 of 13 (76.9%) MSA cases with substantial interrater agreement (Cohen's kappa 0.708; P < .001); no PSP case was misclassified as MSA or vice versa. MRI was less sensitive but more specific than clinical diagnosis in PSP and both more sensitive and specific than clinical diagnosis in MSA. The "hummingbird" and "morning glory" signs were highly specific for PSP, and "the middle cerebellar peduncle sign" and "hot cross bun" for MSA, but sensitivity was lower (up to 68.4%) and characteristic findings may not be present even at autopsy. cMRI, clinical diagnosis, and macroscopic examination at postmortem have similar sensitivity and specificity in predicting a neuropathological diagnosis. We have validated specific radiological signs in pathologically confirmed PSP and MSA. However, the low sensitivity of these and macroscopic findings at autopsy suggest a need for imaging techniques sensitive to microstructural abnormalities without regional atrophy. 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/api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944819 /api/authorship/120944819 5 0.071428575 false false false Ling Helen true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944820 /api/authorship/120944820 6 0.071428575 false false false Williams David R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944821 /api/authorship/120944821 7 0.071428575 false false false Kallis Constantinos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944822 /api/authorship/120944822 8 0.071428575 false false false Holton Janice L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 120944823 /api/authorship/120944823 9 0.071428575 false false false Author 10097351 /api/author/10097351 Révész Tamás true true Revesz Tamas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 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