TY - JOUR AU - Rácz, Gergely AU - Takács, Hedvig AU - Kormányos, Árpád AU - Polestyuk, Bianka Petra AU - Borbás, János AU - Gyenes, Nándor AU - Schvartz, Noémi AU - Németh, Gergely AU - Kincses, Zsigmond Tamás AU - Sepp, Róbert AU - Nagy, Viktória TI - Screening for Myocardial Injury after Mild SARS-CoV-2 Infection with Advanced Transthoracic Echocardiography Modalities JF - DIAGNOSTICS J2 - DIAGNOSTICS VL - 12 PY - 2022 IS - 8 PG - 13 SN - 2075-4418 DO - 10.3390/diagnostics12081941 UR - https://m2.mtmt.hu/api/publication/33051869 ID - 33051869 N1 - Division of Non-Invasive Cardiology, Department of Internal Medicine, University of Szeged, Szeged, 6725, Hungary Department of Radiology, University of Szeged, Szeged, 6725, Hungary Cited By :4 Export Date: 20 June 2024 Correspondence Address: Sepp, R.; Division of Non-Invasive Cardiology, Hungary; email: sepprobert@gmail.com Chemicals/CAS: favipiravir, 259793-96-9; remdesivir, 1809249-37-3; troponin T, 60304-72-5 Tradenames: Vivid E95 R3, GE Healthcare Manufacturers: GE Healthcare Funding text 1: The research was funded by the “Hetényi Géza” grant of the Faculty of Medicine, University of Szeged provided to R.S. The publication of the manuscript was funded by the MED-EN TRADE KFT. (2400 Dunaújváros, Petőfi utca 63). AB - Although the clinical manifestations of SARS-CoV-2 viral infection affect mainly the respiratory system, cardiac complications are common and are associated with increased morbidity and mortality. While echocardiographic alterations indicating myocardial involvement are widely reported in patients hospitalized for acute COVID-19 infection, much fewer data available in non-hospitalized, mildly symptomatic COVID-19 patients. In our work, we aimed to investigate subclinical cardiac alterations characterized by parameters provided by advanced echocardiographic techniques following mild SARS-CoV-2 viral infection. A total of 86 patients (30 males, age: 39.5 ± 13.0 yrs) were assessed 59 ± 33 days after mild SARS-CoV-2 viral infection (requiring no hospital or <5 days in-hospital treatment) by advanced echocardiographic examination including 2-dimensional (2D) speckle tracking echocardiography and non-invasive myocardial work analysis, and were compared to an age-and sex-matched control group. Altogether, variables from eleven echocardiographic categories representing morphological or functional echocardiographic parameters showed statistical difference between the post-COVID patient group and the control group. The magnitude of change was subtle or mild in the case of these parameters, ranging from 1–11.7% of relative change. Among the parameters, global longitudinal strain [−20.3 (−21.1–−19.0) vs. −19.1 (−20.4–−17.6) %; p = 0.0007], global myocardial work index [1975 (1789–2105) vs. 1829 (1656–2057) Hgmm%; p = 0.007] and right ventricular free wall strain values (−26.6 ± 3.80 vs. −23.8 ± 4.0%; p = 0.0003) showed the most significant differences between the two groups. Subclinical cardiac alterations are present following even mild SARS-CoV-2 viral infection. These more subtle alterations are difficult to detect by routine echocardiography. Extended protocols, involving speckle-tracking echocardiography, non-invasive measurement of cardiac hemodynamics, and possibly myocardial work are necessary for detection and adequate follow-up. LA - English DB - MTMT ER - TY - JOUR AU - Sepp, Róbert AU - Hategan, Lídia AU - Csányi, Beáta AU - Borbás, János AU - Tringer, Annamária AU - Pálinkás, Eszter Dalma AU - Nagy, Viktória AU - Takács, Hedvig AU - Latinovics, Dóra AU - Nyolczas, Noémi AU - Pálinkás, Attila AU - Faludi, Réka AU - Rábai, Miklós AU - Szabó, Gábor Tamás AU - Czuriga, Dániel AU - Balogh, László AU - Halmosi, Róbert AU - Borbély, Attila AU - Habon, Tamás AU - Hegedűs, Zoltán AU - Nagy, István TI - The Genetic Architecture of Hypertrophic Cardiomyopathy in Hungary: Analysis of 242 Patients with a Panel of 98 Genes JF - DIAGNOSTICS J2 - DIAGNOSTICS VL - 12 PY - 2022 IS - 5 PG - 12 SN - 2075-4418 DO - 10.3390/diagnostics12051132 UR - https://m2.mtmt.hu/api/publication/32804523 ID - 32804523 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Csányi, Beáta AU - Hategan, Lídia AU - Nagy, Viktória AU - Obál, Izabella AU - Varga, Edina Tímea AU - Borbás, János AU - Tringer, Annamária AU - Sabrina, Eichler AU - Forster, Tamás AU - Arndt, Rolfs AU - Sepp, Róbert TI - Identification of a Novel GLA Gene Mutation, p.Ile239Met, in Fabry Disease with a Predominant Cardiac Phenotype. [case report] TS - [case report] JF - INTERNATIONAL HEART JOURNAL J2 - INT HEART J VL - 58 PY - 2017 IS - 3 SP - 454 EP - 458 PG - 5 SN - 1349-2365 DO - 10.1536/ihj.16-361 UR - https://m2.mtmt.hu/api/publication/3110752 ID - 3110752 N1 - Szövegében 3 oldalas esetismertetés, ezért besorolása rövid közlemény az MTA V. Osztályának ajánlása alapján. (BSzÁ, SZTE admin5, 2024-06-26) LA - English DB - MTMT ER - TY - JOUR AU - Csányi, Beáta AU - Popoiu, A AU - Hategan, Lídia AU - Hegedűs, Zoltán AU - Nagy, Viktória AU - Rácz, Katalin Róza AU - Hőgye, Márta AU - Sághy, László AU - Iványi, Béla AU - Csanády, Miklós AU - Forster, Tamás AU - Sepp, Róbert TI - Identification of two novel LAMP2 gene mutations in Danon disease JF - CANADIAN JOURNAL OF CARDIOLOGY J2 - CAN J CARDIOL VL - 32 PY - 2016 IS - 11 SP - 1355.e23 EP - 1355.e30 SN - 0828-282X DO - 10.1016/j.cjca.2016.02.071 UR - https://m2.mtmt.hu/api/publication/3026076 ID - 3026076 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Tímea AU - Nagy, Viktória AU - Faludi, Réka AU - Csanády, Miklós AU - Nemes, Attila AU - Simor, Tamás AU - Forster, Tamás AU - Sepp, Róbert TI - The Gln1233ter mutation of the myosin binding protein C gene: Causative mutation or innocent polymorphism in patients with hypertrophic cardiomyopathy? JF - INTERNATIONAL JOURNAL OF CARDIOLOGY J2 - INT J CARDIOL VL - 153 PY - 2011 IS - 2 SP - 216 EP - 219 PG - 4 SN - 0167-5273 DO - 10.1016/j.ijcard.2011.09.062 UR - https://m2.mtmt.hu/api/publication/1745328 ID - 1745328 N1 - Letter to the Editor LA - English DB - MTMT ER -