TY - JOUR AU - Glikson, Michael AU - Nielsen, Jens Cosedis AU - Kronborg, Mads Brix AU - Michowitz, Yoav AU - Auricchio, Angelo AU - Barbash, Israel Moshe AU - Barrabes, Jose A. AU - Boriani, Giuseppe AU - Braunschweig, Frieder AU - Brignole, Michele AU - Burri, Haran AU - Coats, Andrew J. S. AU - Deharo, Jean-Claude AU - Delgado, Victoria AU - Diller, Gerhard-Paul AU - Israel, Carsten W. AU - Keren, Andre AU - Knops, Reinoud E. AU - Kotecha, Dipak AU - Leclercq, Christophe AU - Merkely, Béla Péter AU - Starck, Christoph AU - Thylen, Ingela AU - Tolosana, Maria ED - Nagy, Klaudia Vivien / Collaborator ED - Gellér, László Alajos / Collaborator TI - 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA) JF - EUROPACE J2 - EUROPACE VL - 24 PY - 2022 IS - 1 SP - 71 EP - 164 PG - 94 SN - 1099-5129 DO - 10.1093/europace/euab232 UR - https://m2.mtmt.hu/api/publication/32651421 ID - 32651421 N1 - Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark Jesselson Integrated Heart Center, Faculty of Medicine, Hebrew University, Shaare Zedek Medical Center, Jerusalem, Israel Department of Cardiology, Istituto Cardiocentro Ticino, Lugano, Switzerland Leviev Heart Center, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Ramat Gan, Israel Department of Cardiology, Vall d'Hebron Hospital Universitari, Universitat Autonoma de Barcelona, CIBERCV, Barcelona, Spain Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden Department of Cardiology, IRCCS Istituto Auxologico Italiano, Milan, Italy Department of Cardiology, University Hospital of Geneva, Geneva, Switzerland Faculty of Medicine, University of Warwick, Coventry, United Kingdom Cardiology La Timone, Aix Marseille Universite, Marseille, France Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands Department of Cardiology III, Adult Congenital and Valvular Heart Disease, University Hospital Muenster, Muenster, Germany Department of Medicine-Cardiology, Diabetology and Nephrology, Bethel-Clinic, Bielefeld, Germany Department of Cardiology, Hadassah-Hebrew University Hospital, Jerusalem, Israel Cardiology and Electrophysiology, Amsterdam University Medical Center, Amsterdam, Netherlands Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom Department of Cadiology, Rennes University Hospital, Rennes, France Heart and Vascular Center, Semmelweis University, Budapest, Hungary Department of Cardiothoracic & Vascular Surgery, German Heart Center Berlin, Berlin, Germany Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden Arrhythmia Section, Cardiovascular Institute, Hospital Clinic, University of Barcelona, Catalonia, Barcelona, Spain Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark Cited By :129 Export Date: 9 May 2024 CODEN: EUROC Correspondence Address: Nielsen, J.C.; Department of Cardiology, Denmark; email: jenniels@rm.dk Correspondence Address: Glikson, M.; Jesselson Integrated Heart Center, Israel; email: mglikson@szmc.org.il LA - English DB - MTMT ER - TY - JOUR AU - Merkely, Béla Péter AU - Gellér, László Alajos AU - Zima, Endre István AU - Osztheimer, István AU - Molnár, Levente Domonkos AU - Földesi, Csaba László AU - Duray, Gábor Zoltán AU - Wranicz, Jerzy K AU - Németh, Marianna AU - Goscinska-Bis, Kinga AU - Hatala, Robert AU - Sághy, László AU - Veres, Boglárka AU - Schwertner, Walter Richard AU - Fábián, Alexandra AU - Fodor, Eszter AU - Goldenberg, Ilan AU - Kutyifa, Valentina AU - Kovács, Attila AU - Kosztin, Annamária TI - Baseline clinical characteristics of heart failure patients with reduced ejection fraction enrolled in the BUDAPEST-CRT Upgrade trial JF - EUROPEAN JOURNAL OF HEART FAILURE J2 - EUR J HEART FAIL VL - 24 PY - 2022 IS - 9 SP - 1652 EP - 1661 PG - 10 SN - 1388-9842 DO - 10.1002/ejhf.2609 UR - https://m2.mtmt.hu/api/publication/32925440 ID - 32925440 N1 - Funding Agency and Grant Number: Boston Scientific (St. Paul, MN, USA); National Research Development and Innovation Fund of Hungary, financed under the NVKP_16 funding scheme [NVKP_16-1-2016-0017]; Ministry for Innovation and Technology in Hungary [2020-4.1.1.-TKP2020]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences Funding text: The study is supported by an unrestricted research grant from the Boston Scientific (St. Paul, MN, USA) Investigator Sponsored Research Fund to the Semmelweis University, Budapest, Hungary. This work was supported by the "National Heart Program" (Project no. NVKP_16-1-2016-0017) with the support provided by the National Research Development and Innovation Fund of Hungary, financed under the NVKP_16 funding scheme. The research was financed by the Thematic Excellence Program (2020-4.1.1.-TKP2020) of the Ministry for Innovation and Technology in Hungary, within the framework of the Therapeutic Development and Bioimaging thematic programs of the Semmelweis University. A. Kosztin was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences Declaration of interest. RRF-2.3.1-21-2022-00003 has been implemented with the support provided by the European Union. AB - The BUDAPEST-CRT Upgrade study is the first prospective, randomized, multicentre clinical trial investigating the outcomes after cardiac resynchronization therapy (CRT) upgrade in heart failure (HF) patients with intermittent or permanent right ventricular pacing (RVP) with wide paced QRS. This report describes the baseline clinical characteristics of the enrolled patients and compares them to cohorts from previous milestone CRT studies.This international multicentre randomized controlled trial investigates 360 patients having a pacemaker (PM) or implantable cardioverter defibrillator (ICD) device for at least six months prior to enrollment, reduced left ventricular ejection fraction (LVEF≤35%), HF symptoms (New York Heart Association functional class II-IVa), wide paced QRS (>150 ms), and ≥20% of RVP burden without having a native left bundle branch block. At enrollment, the mean age of the patients was 73±8 years; 89% were male, 97% of the patients were in NYHA II/III functional class, and 56% had atrial fibrillation. Enrolled patients predominantly had conventional PM devices, with a mean RVP burden of 86%. Thus, this is a patient cohort with advanced HF, low baseline LVEF (25%±7%), high N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels [2231 pg/mL (25th - 75th percentile 1254/4309 pg/mL)], and frequent HF hospitalizations during the preceding 12 months (50%).When compared with prior CRT trial cohorts, the BUDAPEST-CRT Upgrade study includes older patients with a strong male predominance and a high burden of atrial fibrillation and other comorbidities. Moreover, this cohort represents an advanced HF population with low LVEFs, high NT-proBNPs, and frequent previous HF events. LA - English DB - MTMT ER - TY - JOUR AU - Glikson, Michael AU - Nielsen, Jens Cosedis AU - Kronborg, Mads Brix AU - Michowitz, Yoav AU - Auricchio, Angelo AU - Barbash, Israel Moshe AU - Barrabes, Jose A. AU - Boriani, Giuseppe AU - Braunschweig, Frieder AU - Brignole, Michele AU - Burri, Haran AU - Coats, Andrew J. S. AU - Deharo, Jean-Claude AU - Delgado, Victoria AU - Diller, Gerhard-Paul AU - Israel, Carsten W. AU - Keren, Andre AU - Knops, Reinoud E. AU - Kotecha, Dipak AU - Leclercq, Christophe AU - Merkely, Béla Péter AU - Starck, Christoph AU - Thylen, Ingela AU - Maria, Tolosana Jose ED - Nagy, Klaudia Vivien / Collaborator ED - Gellér, László Alajos / Collaborator TI - 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA) JF - EUROPEAN HEART JOURNAL J2 - EUR HEART J VL - 42 PY - 2021 IS - 35 SP - 3427 EP - 3520 PG - 94 SN - 0195-668X DO - 10.1093/eurheartj/ehab364 UR - https://m2.mtmt.hu/api/publication/32551589 ID - 32551589 LA - English DB - MTMT ER - TY - JOUR AU - Kosztin, Annamária AU - Vámos, Máté AU - Aradi, Dániel AU - Schwertner, Walter Richard AU - Kovács, Attila AU - Nagy, Klaudia Vivien AU - Zima, Endre István AU - Gellér, László Alajos AU - Duray, Gábor Zoltán AU - Kutyifa, Valentina AU - Merkely, Béla Péter TI - De novo implantation vs. upgrade cardiac resynchronization therapy: a systematic review and meta-analysis JF - HEART FAILURE REVIEWS J2 - HEART FAIL REV VL - 23 PY - 2018 IS - 1 SP - 15 EP - 26 PG - 12 SN - 1382-4147 DO - 10.1007/s10741-017-9652-1 UR - https://m2.mtmt.hu/api/publication/3287466 ID - 3287466 N1 - Heart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary University Hospital Frankfurt—Goethe University, Frankfurt am Main, Germany Medical Centre—Hungarian Defence Forces, Budapest, Hungary Heart Center, Balatonfüred, Hungary University of Rochester, Medical Center, Rochester, NY, United States Cited By :32 Export Date: 4 January 2024 CODEN: HFREF Correspondence Address: Merkely, B.; Heart and Vascular Center, 68 Városmajor Street, Hungary; email: merkely.bela@kardio.sote.hu Funding text 1: Funding information This study was supported by the National Research, Development and Innovation Office (NKFIH) of Hungary (NVKP_16-1-2016-0017 to B. M.). Funding text 2: Mate Vamos reports lecture fees from Bayer, Pfizer and Spectranetics and support attending scientific meetings from Bayer, Boston Scientific, Pfizer and SJM, outside the submitted work. Endre Zima reports consulting fees and honoraria from Bayer, Biotronik, Boston Scientific, Innomed, Medtronic and St. Jude Medical for lectures, training and participation in clinical trials. Laszlo Geller reports consulting fees/honoraria from Biotronik, Medtronic, St. Jude Medical and Johnson & Johnson. Gabor Z. Duray served as a member of the steering committee of the Micra Study and reports research grants from Boston Scientific, Biotronik and Medtronic and speakers bureau/consulting fees from Biotronik, Medtronic, St. Jude Medical, Bayer and Boehringer Ingelheim. Bela Merkely reports consulting/lecture fees from Biotronik, Boston Scientific, Medtronic, St. Jude Medical and Terumo. Annamaria Kosztin, Daniel Aradi, Attila Kovacs, Richard Schwertner, Valentina Kutyifa and Klaudia Vivien Nagy have nothing to disclose. AB - Patients with conventional pacemakers or implanted defibrillators are often considered for cardiac resynchronization therapy (CRT). Our aim was to summarize the available evidences regarding the clinical benefits of upgrade procedures. A systematic literature search was performed from studies published between 2006 and 2017 in order to compare the outcome of CRT upgrade vs. de novo implantations. Outcome data on all-cause mortality, heart failure events, New York Heart Association (NYHA) Class, QRS narrowing and echocardiographic parameters were analysed. A total of 16 reports were analysed comprising 489,568 CRT recipients, of whom 468,205 patients underwent de novo and 21,363 upgrade procedures. All-cause mortality was similar after CRT upgrade compared to de novo implantations (RR 1.19, 95% CI 0.88-1.60, p = 0.27). The risk of heart failure was also similar in both groups (RR 0.96, 95% CI 0.70-1.32, p = 0.81). There was no significant difference in clinical response after CRT upgrade compared to de novo implantations in terms of improvement in left ventricular ejection fraction (DeltaEF de novo - 6.85% vs. upgrade - 9.35%; p = 0.235), NYHA class (DeltaNYHA de novo - 0.74 vs. upgrade - 0.70; p = 0.737) and QRS narrowing (DeltaQRS de novo - 9.6 ms vs. upgrade - 29.5 ms; p = 0.485). Our systematic review and meta-analysis of currently available studies reports that CRT upgrade is associated with similar risk for all-cause mortality compared to de novo resynchronization therapy. Benefits on reverse remodelling and functional capacity improved similarly in both groups suggesting that CRT upgrade may be safely and effectively offered in routine practice. CLINICAL TRIAL REGISTRATION: Prospero Database-CRD42016043747. LA - English DB - MTMT ER - TY - JOUR AU - Merkely, Béla Péter AU - Kosztin, Annamária AU - Róka, Attila AU - Gellér, László Alajos AU - Zima, Endre István AU - Kovács, Attila AU - Boros, András Mihály AU - Klein, H AU - Wranicz, JK AU - Hindricks, G AU - Clemens, Marcell AU - Duray, Gábor Zoltán AU - Moss, AJ AU - Goldenberg, I AU - Kutyifa, Valentina TI - Rationale and design of the BUDAPEST-CRT Upgrade Study. a prospective, randomized, multicentre clinical trial TS - a prospective, randomized, multicentre clinical trial JF - EUROPACE J2 - EUROPACE VL - 19 PY - 2017 IS - 9 SP - 1549 EP - 1555 PG - 7 SN - 1099-5129 DO - 10.1093/europace/euw193 UR - https://m2.mtmt.hu/api/publication/3184094 ID - 3184094 N1 - Goldenberg I and Kutyifa V authors contributed equally to this article. 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