@article{MTMT:32651421, title = {2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA)}, url = {https://m2.mtmt.hu/api/publication/32651421}, author = {Glikson, Michael and Nielsen, Jens Cosedis and Kronborg, Mads Brix and Michowitz, Yoav and Auricchio, Angelo and Barbash, Israel Moshe and Barrabes, Jose A. and Boriani, Giuseppe and Braunschweig, Frieder and Brignole, Michele and Burri, Haran and Coats, Andrew J. S. and Deharo, Jean-Claude and Delgado, Victoria and Diller, Gerhard-Paul and Israel, Carsten W. and Keren, Andre and Knops, Reinoud E. and Kotecha, Dipak and Leclercq, Christophe and Merkely, Béla Péter and Starck, Christoph and Thylen, Ingela and Tolosana, Maria}, doi = {10.1093/europace/euab232}, journal-iso = {EUROPACE}, journal = {EUROPACE}, volume = {24}, unique-id = {32651421}, issn = {1099-5129}, keywords = {COMPLICATIONS; heart failure; bradycardia; TERM-FOLLOW-UP; GUIDELINES; syncope; QUALITY-OF-LIFE; Pacemaker; Bundle-Branch Block; Atrial Fibrillation; Cardiac pacing; cardiac resynchronization therapy; AORTIC-VALVE IMPLANTATION; SICK SINUS SYNDROME; EXPERT CONSENSUS STATEMENT; PERMANENT PACEMAKER IMPLANTATION; COMPLETE ATRIOVENTRICULAR-BLOCK; LEFT-VENTRICULAR LEAD; conduction system pacing; pacing indications; alternate site pacing; pacing in TAVI}, year = {2022}, eissn = {1532-2092}, pages = {71-164}, orcid-numbers = {Nielsen, Jens Cosedis/0000-0001-9414-1653; Merkely, Béla Péter/0000-0001-6514-0723; Nagy, Klaudia Vivien/0000-0001-6878-1892; Gellér, László Alajos/0000-0001-6802-6360} } @article{MTMT:32925440, title = {Baseline clinical characteristics of heart failure patients with reduced ejection fraction enrolled in the BUDAPEST-CRT Upgrade trial}, url = {https://m2.mtmt.hu/api/publication/32925440}, author = {Merkely, Béla Péter and Gellér, László Alajos and Zima, Endre István and Osztheimer, István and Molnár, Levente Domonkos and Földesi, Csaba László and Duray, Gábor Zoltán and Wranicz, Jerzy K and Németh, Marianna and Goscinska-Bis, Kinga and Hatala, Robert and Sághy, László and Veres, Boglárka and Schwertner, Walter Richard and Fábián, Alexandra and Fodor, Eszter and Goldenberg, Ilan and Kutyifa, Valentina and Kovács, Attila and Kosztin, Annamária}, doi = {10.1002/ejhf.2609}, journal-iso = {EUR J HEART FAIL}, journal = {EUROPEAN JOURNAL OF HEART FAILURE}, volume = {24}, unique-id = {32925440}, issn = {1388-9842}, abstract = {The BUDAPEST-CRT Upgrade study is the first prospective, randomized, multicentre clinical trial investigating the outcomes after cardiac resynchronization therapy (CRT) upgrade in heart failure (HF) patients with intermittent or permanent right ventricular pacing (RVP) with wide paced QRS. This report describes the baseline clinical characteristics of the enrolled patients and compares them to cohorts from previous milestone CRT studies.This international multicentre randomized controlled trial investigates 360 patients having a pacemaker (PM) or implantable cardioverter defibrillator (ICD) device for at least six months prior to enrollment, reduced left ventricular ejection fraction (LVEF≤35%), HF symptoms (New York Heart Association functional class II-IVa), wide paced QRS (>150 ms), and ≥20% of RVP burden without having a native left bundle branch block. At enrollment, the mean age of the patients was 73±8 years; 89% were male, 97% of the patients were in NYHA II/III functional class, and 56% had atrial fibrillation. Enrolled patients predominantly had conventional PM devices, with a mean RVP burden of 86%. Thus, this is a patient cohort with advanced HF, low baseline LVEF (25%±7%), high N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels [2231 pg/mL (25th - 75th percentile 1254/4309 pg/mL)], and frequent HF hospitalizations during the preceding 12 months (50%).When compared with prior CRT trial cohorts, the BUDAPEST-CRT Upgrade study includes older patients with a strong male predominance and a high burden of atrial fibrillation and other comorbidities. Moreover, this cohort represents an advanced HF population with low LVEFs, high NT-proBNPs, and frequent previous HF events.}, keywords = {cardiac resynchronization therapy; UPGRADE; pacing-induced cardiomyopathy; CRT upgrade; RV pacing}, year = {2022}, eissn = {1879-0844}, pages = {1652-1661}, orcid-numbers = {Merkely, Béla Péter/0000-0001-6514-0723; Gellér, László Alajos/0000-0001-6802-6360; Zima, Endre István/0000-0001-5132-6009; Osztheimer, István/0000-0002-8209-990X; Duray, Gábor Zoltán/0000-0003-1286-6576; Németh, Marianna/0009-0004-3920-1392; Veres, Boglárka/0000-0002-3889-3794; Schwertner, Walter Richard/0000-0002-6206-243X; Fábián, Alexandra/0000-0002-8449-0638; Kutyifa, Valentina/0000-0002-0016-289X; Kovács, Attila/0000-0003-2320-6434; Kosztin, Annamária/0000-0001-6647-2623} } @article{MTMT:32551589, title = {2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA)}, url = {https://m2.mtmt.hu/api/publication/32551589}, author = {Glikson, Michael and Nielsen, Jens Cosedis and Kronborg, Mads Brix and Michowitz, Yoav and Auricchio, Angelo and Barbash, Israel Moshe and Barrabes, Jose A. and Boriani, Giuseppe and Braunschweig, Frieder and Brignole, Michele and Burri, Haran and Coats, Andrew J. S. and Deharo, Jean-Claude and Delgado, Victoria and Diller, Gerhard-Paul and Israel, Carsten W. and Keren, Andre and Knops, Reinoud E. and Kotecha, Dipak and Leclercq, Christophe and Merkely, Béla Péter and Starck, Christoph and Thylen, Ingela and Maria, Tolosana Jose}, doi = {10.1093/eurheartj/ehab364}, journal-iso = {EUR HEART J}, journal = {EUROPEAN HEART JOURNAL}, volume = {42}, unique-id = {32551589}, issn = {0195-668X}, keywords = {COMPLICATIONS; heart failure; bradycardia; TERM-FOLLOW-UP; GUIDELINES; syncope; QUALITY-OF-LIFE; Pacemaker; Bundle-Branch Block; Atrial Fibrillation; Cardiac pacing; cardiac resynchronization therapy; AORTIC-VALVE IMPLANTATION; SICK SINUS SYNDROME; EXPERT CONSENSUS STATEMENT; PERMANENT PACEMAKER IMPLANTATION; COMPLETE ATRIOVENTRICULAR-BLOCK; LEFT-VENTRICULAR LEAD; conduction system pacing; pacing indications; alternate site pacing; pacing in TAVI}, year = {2021}, eissn = {1522-9645}, pages = {3427-3520}, orcid-numbers = {Nielsen, Jens Cosedis/0000-0001-9414-1653; Merkely, Béla Péter/0000-0001-6514-0723; Nagy, Klaudia Vivien/0000-0001-6878-1892; Gellér, László Alajos/0000-0001-6802-6360} } @article{MTMT:3287466, title = {De novo implantation vs. upgrade cardiac resynchronization therapy: a systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/3287466}, author = {Kosztin, Annamária and Vámos, Máté and Aradi, Dániel and Schwertner, Walter Richard and Kovács, Attila and Nagy, Klaudia Vivien and Zima, Endre István and Gellér, László Alajos and Duray, Gábor Zoltán and Kutyifa, Valentina and Merkely, Béla Péter}, doi = {10.1007/s10741-017-9652-1}, journal-iso = {HEART FAIL REV}, journal = {HEART FAILURE REVIEWS}, volume = {23}, unique-id = {3287466}, issn = {1382-4147}, abstract = {Patients with conventional pacemakers or implanted defibrillators are often considered for cardiac resynchronization therapy (CRT). Our aim was to summarize the available evidences regarding the clinical benefits of upgrade procedures. A systematic literature search was performed from studies published between 2006 and 2017 in order to compare the outcome of CRT upgrade vs. de novo implantations. Outcome data on all-cause mortality, heart failure events, New York Heart Association (NYHA) Class, QRS narrowing and echocardiographic parameters were analysed. A total of 16 reports were analysed comprising 489,568 CRT recipients, of whom 468,205 patients underwent de novo and 21,363 upgrade procedures. All-cause mortality was similar after CRT upgrade compared to de novo implantations (RR 1.19, 95% CI 0.88-1.60, p = 0.27). The risk of heart failure was also similar in both groups (RR 0.96, 95% CI 0.70-1.32, p = 0.81). There was no significant difference in clinical response after CRT upgrade compared to de novo implantations in terms of improvement in left ventricular ejection fraction (DeltaEF de novo - 6.85% vs. upgrade - 9.35%; p = 0.235), NYHA class (DeltaNYHA de novo - 0.74 vs. upgrade - 0.70; p = 0.737) and QRS narrowing (DeltaQRS de novo - 9.6 ms vs. upgrade - 29.5 ms; p = 0.485). Our systematic review and meta-analysis of currently available studies reports that CRT upgrade is associated with similar risk for all-cause mortality compared to de novo resynchronization therapy. Benefits on reverse remodelling and functional capacity improved similarly in both groups suggesting that CRT upgrade may be safely and effectively offered in routine practice. CLINICAL TRIAL REGISTRATION: Prospero Database-CRD42016043747.}, year = {2018}, eissn = {1573-7322}, pages = {15-26}, orcid-numbers = {Kosztin, Annamária/0000-0001-6647-2623; Schwertner, Walter Richard/0000-0002-6206-243X; Kovács, Attila/0000-0003-2320-6434; Nagy, Klaudia Vivien/0000-0001-6878-1892; Zima, Endre István/0000-0001-5132-6009; Gellér, László Alajos/0000-0001-6802-6360; Duray, Gábor Zoltán/0000-0003-1286-6576; Kutyifa, Valentina/0000-0002-0016-289X; Merkely, Béla Péter/0000-0001-6514-0723} } @article{MTMT:3184094, title = {Rationale and design of the BUDAPEST-CRT Upgrade Study. a prospective, randomized, multicentre clinical trial}, url = {https://m2.mtmt.hu/api/publication/3184094}, author = {Merkely, Béla Péter and Kosztin, Annamária and Róka, Attila and Gellér, László Alajos and Zima, Endre István and Kovács, Attila and Boros, András Mihály and Klein, H and Wranicz, JK and Hindricks, G and Clemens, Marcell and Duray, Gábor Zoltán and Moss, AJ and Goldenberg, I and Kutyifa, Valentina}, doi = {10.1093/europace/euw193}, journal-iso = {EUROPACE}, journal = {EUROPACE}, volume = {19}, unique-id = {3184094}, issn = {1099-5129}, year = {2017}, eissn = {1532-2092}, pages = {1549-1555}, orcid-numbers = {Merkely, Béla Péter/0000-0001-6514-0723; Kosztin, Annamária/0000-0001-6647-2623; Gellér, László Alajos/0000-0001-6802-6360; Zima, Endre István/0000-0001-5132-6009; Kovács, Attila/0000-0003-2320-6434; Duray, Gábor Zoltán/0000-0003-1286-6576; Kutyifa, Valentina/0000-0002-0016-289X} } @article{MTMT:3176362, title = {2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.}, url = {https://m2.mtmt.hu/api/publication/3176362}, author = {Ponikowski, P and Voors, AA and Anker, SD and Bueno, H and Cleland, JG and Coats, AJ and Falk, V and Gonzalez-Juanatey, JR and Harjola, VP and Jankowska, EA and Jessup, M and Linde, C and Nihoyannopoulos, P and Parissis, JT and Pieske, B and Riley, JP and Rosano, GM and Ruilope, LM and Ruschitzka, F and Rutten, FH and van der Meer, P}, doi = {10.1093/eurheartj/ehw128}, journal-iso = {EUR HEART J}, journal = {EUROPEAN HEART JOURNAL}, volume = {37}, unique-id = {3176362}, issn = {0195-668X}, year = {2016}, eissn = {1522-9645}, pages = {2129-2200}, orcid-numbers = {Nyolczas, Noémi/0000-0001-9466-0939} } @article{MTMT:30416268, title = {Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure.}, url = {https://m2.mtmt.hu/api/publication/30416268}, author = {Tang, Anthony S. L. and Wells, George A. and Talajic, Mario and Arnold, Malcolm O. and Sheldon, Robert and Connolly, Stuart and Hohnloser, Stefan H. and Nichol, Graham and Birnie, David H. and Sapp, John L. and Yee, Raymond and Healey, Jeffrey S. and Rouleau, Jean L.}, doi = {10.1056/NEJMoa1009540}, journal-iso = {NEW ENGL J MED}, journal = {NEW ENGLAND JOURNAL OF MEDICINE}, volume = {363}, unique-id = {30416268}, issn = {0028-4793}, year = {2010}, eissn = {1533-4406}, pages = {2385-2395}, orcid-numbers = {Wells, George A./0000-0002-2289-9139; Duray, Gábor Zoltán/0000-0003-1286-6576} }