https://m2.mtmt.hu/ hun 2026-07-16 06:59 true true 1 3 3 1 100 1 3 DESC publishedYear false ASC firstAuthor true ASC title true JournalArticle 32666145 VALIDATED true Tamás Radovits and János Szebeni contributed equally to the article. 0 false 2026-05-21T14:52:18.987+0000 2024-01-04T07:36:44.175+0000 2022-02-11T08:56:52.791+0000 true 10069606 Pintér Ibolya Katalin /api/admin/10069606 Admin true 2025-03-06T13:03:29.537+0000 2024-01-04T07:36:45.050+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Dézsi, László A naturally hypersensitive porcine model may help understand the mechanism of COVID-19 mRNA vaccine-induced rare (pseudo) allergic reactions: complement activation as a possible contributing factor true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 44 2 597 618 597 22 2022 A tiny fraction of people immunized with lipid nanoparticle (LNP)-enclosed mRNA (LNP-mRNA) vaccines develop allergic symptoms following their first or subsequent vaccinations, including anaphylaxis. These reactions resemble complement (C) activation-related pseudoallergy (CARPA) to i.v. administered liposomes, for which pigs provide a naturally oversensitive model. Using this model, we injected i.v. the human vaccination dose (HVD) of BNT162b2 (Comirnaty, CMT) or its 2-fold (2x) or 5-fold (5x) amounts and measured the hemodynamic changes and other parameters of CARPA. We observed in 6 of 14 pigs transient pulmonary hypertension along with thromboxane A2 release into the blood and other hemodynamic and blood cell changes, including hypertension, granulocytosis, lymphopenia, and thrombocytopenia. One pig injected with 5x CMT developed an anaphylactic shock requiring resuscitation, while a repeat dose failed to induce the reaction, implying tachyphylaxis. These typical CARPA symptoms could not be linked to animal age, sex, prior immune stimulation with zymosan, immunization of animals with Comirnaty i.v., or i.m. 2 weeks before the vaccine challenge, and anti-PEG IgM levels in Comirnaty-immunized pigs. Nevertheless, IgM binding to the whole vaccine, used as antigen in an ELISA, was significantly higher in reactive animals compared to non-reactive ones. Incubation of Comirnaty with pig serum in vitro showed significant elevations of C3a anaphylatoxin and sC5b-9, the C-terminal complex. These data raise the possibility that C activation plays a causal or contributing role in the rare HSRs to Comirnaty and other vaccines with similar side effects. Further studies are needed to uncover the factors controlling these vaccine reactions in pigs and to understand their translational value to humans. Funding 2010441 /api/funding/2010441 false true Funding 2010442 /api/funding/2010442 false true Funding 2010443 /api/funding/2010443 false true Funding 2010444 /api/funding/2010444 false true true true 2022 true true true false true false GREEN 2026-05-21 true https://doi.org/10.1007/s11357-021-00495-y 48 0 44 32 13 44 44 41 37 44 44 32 32 34 14 0 48 34 44 32 0 20 20 D1 false 10005165,10075617 false false false 2022-02-20T14:12:01.078+0000 Elméleti Egészségtudományok Intézete (ME / ETK); Nanomedicina Kutató és Oktató Központ (SE / AOK / I / KKI); Sportorvostan Tanszék (SE / AOK / K); Transzlációs Medicina Intézet (SE / AOK / I); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 11 65 5 14 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 100555569 /api/authorship/100555569 1 0.071 true false false Author 10005165 /api/author/10005165 Dézsi László true 10005165 true Dézsi László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100555570 /api/authorship/100555570 2 0.071 false false false Author 10064003 /api/author/10064003 Mészáros Tamás true 10064003 true Mészáros Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100555571 /api/authorship/100555571 3 0.071 false false false Author 10024742 /api/author/10024742 Kozma Gergely Tibor true 10024742 true Kozma Gergely Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100555572 /api/authorship/100555572 4 0.071428575 false false false H-Velkei Mária true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100555573 /api/authorship/100555573 5 0.071428575 false false false Author 10075617 /api/author/10075617 Oláh Csaba Zsolt true true Oláh Csaba Zs. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100555574 /api/authorship/100555574 6 0.071428575 false false false Author 10092665 /api/author/10092665 Szabó Miklós true true Szabó Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100555575 /api/authorship/100555575 7 0.071428575 false false false Author 10032791 /api/author/10032791 Patkó Zsófia Panna DUPLUM true 10032791 true Patkó Zsófia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100555576 /api/authorship/100555576 8 0.071 false false false Author 10053120 /api/author/10053120 Fülöp Tamás true 10053120 true Fülöp Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100555577 /api/authorship/100555577 9 0.071428575 false false false Hennies Mark true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100555578 /api/authorship/100555578 10 0.071428575 false false false Szebeni Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100555579 /api/authorship/100555579 11 0.071 false false false Author 10072454 /api/author/10072454 Barta Bálint András true true Barta Bálint András true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100555580 /api/authorship/100555580 12 0.071 false false false Author 10002691 /api/author/10002691 Merkely Béla Péter true 10002691 true Merkely Béla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100555581 /api/authorship/100555581 13 0.071 false true false Author 10013969 /api/author/10013969 Radovits Tamás true 10013969 true Radovits Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100555582 /api/authorship/100555582 14 0.071 false true true Author 10003266 /api/author/10003266 Szebeni János true 10003266 true Szebeni János true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 20669930 /api/publicationidentifier/20669930 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GREEN true IDENTICAL 10.1007/s11357-021-00495-y https://doi.org/10.1007/s11357-021-00495-y false true PublicationIdentifier 20757377 /api/publicationidentifier/20757377 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000753709600001 https://www.webofscience.com/wos/woscc/full-record/000753709600001 true true PublicationIdentifier 20702173 /api/publicationidentifier/20702173 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85124573206 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85124573206 false true PublicationIdentifier 20664648 /api/publicationidentifier/20664648 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35146583 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35146583&dopt=Abstract false true SjrRating 11312161 /api/sjrrating/11312161 1 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2707 /api/classificationexternal/2707 true 2707 true D1 DIRECT true true /api/publication/32666145 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10005165"><a href="/gui2/?type=authors&mode=browse&sel=10005165" target="_blank">Dézsi László (<span class="authorship-author-name">Dézsi László</span> <span class="authorAux-mtmt"> Elméleti orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064003"><a href="/gui2/?type=authors&mode=browse&sel=10064003" target="_blank">Mészáros Tamás (<span class="authorship-author-name">Mészáros Tamás</span> <span class="authorAux-mtmt"> nanomedicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024742"><a href="/gui2/?type=authors&mode=browse&sel=10024742" target="_blank">Kozma Gergely Tibor (<span class="authorship-author-name">Kozma Gergely Tibor</span> <span class="authorAux-mtmt"> Immunológia, Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >H-Velkei Mária </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075617"><a href="/gui2/?type=authors&mode=browse&sel=10075617" target="_blank">Oláh Csaba Zs. (<span class="authorship-author-name">Oláh Csaba Zsolt</span> <span class="authorAux-mtmt"> idegsebészet</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10092665"><a href="/gui2/?type=authors&mode=browse&sel=10092665" target="_blank">Szabó Miklós (<span class="authorship-author-name">Szabó Miklós</span> <span class="authorAux-mtmt"> tüdőgyógyászat, klinikai onkológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032791"><a href="/gui2/?type=authors&mode=browse&sel=10032791" target="_blank">Patkó Zsófia (<span class="authorship-author-name">Patkó Zsófia Panna</span> <span class="authorAux-mtmt"> farmakokinetika, nukleáris medicina, radiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053120"><a href="/gui2/?type=authors&mode=browse&sel=10053120" target="_blank">Fülöp Tamás (<span class="authorship-author-name">Fülöp Tamás</span> <span class="authorAux-mtmt"> Liposzomális nanomedicina vizsgálatok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hennies Mark </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szebeni Miklós </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072454"><a href="/gui2/?type=authors&mode=browse&sel=10072454" target="_blank">Barta Bálint András (<span class="authorship-author-name">Barta Bálint András</span> <span class="authorAux-mtmt"> Experimentális kardiológia, Proteomika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Béla (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Sportorvostan Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013969"><a href="/gui2/?type=authors&mode=browse&sel=10013969" target="_blank">Radovits Tamás<sup>**</sup> (<span class="authorship-author-name">Radovits Tamás</span> <span class="authorAux-mtmt"> kardiológia, érgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003266"><a href="/gui2/?type=authors&mode=browse&sel=10003266" target="_blank">Szebeni János ✉ (<span class="authorship-author-name">Szebeni János</span> <span class="authorAux-mtmt"> Klinikai orvostudomány, immunológia, nanomedicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ; <span title="Miskolci Egyetem">ME</span>/<span title="Egészségtudományi Kar ">ETK</span>/Elméleti Egészségtudományok Intézete; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32666145" target="_blank">A naturally hypersensitive porcine model may help understand the mechanism of COVID-19 mRNA vaccine-induced rare (pseudo) allergic reactions: complement activation as a possible contributing factor</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">44</span> <span class="journal-issue">2</span> <span class="page"> pp 597-618 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="10.1007/s11357-021-00495-y" target="_blank" href="https://doi.org/10.1007/s11357-021-00495-y"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000753709600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000753709600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85124573206" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85124573206"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35146583" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35146583&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 48</span> | Független: 34 | Függő: 14 | Nem jelölt: 0 | WoS jelölt: 41 | Scopus jelölt:&nbsp;37 | WoS/Scopus jelölt:&nbsp;44 | DOI jelölt:&nbsp;44 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32666145&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 20 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32666145</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (Open access funding of Semmelweis University), European Union Horizon 2020 projects(825828), European Union Horizon 2020 projects(952520), (2020-1.1.6-JOVO-2021-00013) </div> <div class="lastModified">Utolsó módosítás: 2024.01.04. 08:36 Molnár-Taga Márta (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Tamás Radovits and János Szebeni contributed equally to the article.</pre> </div></div> JournalArticle 31997628 VALIDATED true Nanomedicine Research and Education Center, Institute of Translational Medicine, Semmelweis University, Budapest, Hungary SeroScience LCC, Budapest, Hungary TECOdevelopment GmbH, Rheinbach, Germany MTA-ELTE Complement Research Group, Eötvös Loránd Research Network (ELKH), Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary Second Department of Bioinformatics and Pediatrics, Semmelweis University, Budapest, Hungary Lendület Cancer Biomarker Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary Nanotechnology Characterization Lab, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary Department of Nanobiotechnology and Regenerative Medicine, Faculty of Health, Miskolc University, Miskolc, Hungary Export Date: 25 April 2025; Cited By: 15; Correspondence Address: J. Szebeni; Nanomedicine Research and Education Center, Institute of Translational Medicine, Semmelweis University, Budapest, Hungary; email: szebeni.janos@med.semmelweis-univ.hu 0 false 2026-05-20T19:19:15.841+0000 2026-01-29T15:09:01.389+0000 2021-05-04T08:12:05.536+0000 true 10069606 Pintér Ibolya Katalin /api/admin/10069606 Admin true 2026-01-29T16:07:43.412+0000 2024-12-06T17:58:09.879+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kozma, Gergely Tibor Mini-Factor H Modulates Complement-Dependent IL-6 and IL-10 Release in an Immune Cell Culture (PBMC) Model: Potential Benefits Against Cytokine Storm true true /api/journal/10023324 REVIEWED true false 10023324 false 10023324 true 1664-3224 1664-3224 Journal FOREIGN 12 642860 642860 13 2021 Funding 2009274 /api/funding/2009274 false true Funding 2009275 /api/funding/2009275 false true Funding 2009276 /api/funding/2009276 false true Funding 2009277 /api/funding/2009277 false true Funding 2009278 /api/funding/2009278 false true Funding 2009279 /api/funding/2009279 false true true true 2021 true true true false true false GOLD 2026-05-20 true https://doi.org/10.3389/fimmu.2021.642860 16 0 16 10 5 16 16 13 15 16 16 10 10 10 6 0 16 10 16 10 0 9 9 Q1 false 10024742,10035041 false false false 2021-05-24T07:55:49.278+0000 Elméleti Egészségtudományok Intézete (ME / ETK); II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Immunológiai Tanszék (ELTE / TTK / Bio_I); MTA-ELTE Komplement Kutatócsoport (ELTE / TTK / Bio_I / Imm_Tsz); Nanomedicina Kutató és Oktató Központ (SE / AOK / I / KKI); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI); Transzlációs Medicina Intézet (SE / AOK / I) 8 59 7 11 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 96179915 /api/authorship/96179915 1 0.091 true false false Author 10024742 /api/author/10024742 Kozma Gergely Tibor true 10024742 true Kozma Gergely Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96179916 /api/authorship/96179916 2 0.091 false false false Author 10064003 /api/author/10064003 Mészáros Tamás true 10064003 true Mészáros Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96179917 /api/authorship/96179917 3 0.091 false false false Author 10070223 /api/author/10070223 Bakos Tamás true true Bakos Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96179918 /api/authorship/96179918 4 0.09090909 false false false Hennies Mark true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96179919 /api/authorship/96179919 5 0.09090909 false false false Author 10075321 /api/author/10075321 Bencze Dániel true true Bencze Dániel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96179920 /api/authorship/96179920 6 0.091 false false false Author 10035041 /api/author/10035041 Uzonyi Barbara true 10035041 true Uzonyi Barbara true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96179921 /api/authorship/96179921 7 0.091 false false false Author 10000109 /api/author/10000109 Győrffy Balázs true 10000109 true Győrffy Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96179922 /api/authorship/96179922 8 0.09090909 false false false Cedrone Edward true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96179923 /api/authorship/96179923 9 0.09090909 false false false Dobrovolskaia Marina A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96179924 /api/authorship/96179924 10 0.09090909 false false false Author 10019323 /api/author/10019323 Józsi Mihály true 10019323 true Józsi Mihály true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96179925 /api/authorship/96179925 11 0.091 false true true Author 10003266 /api/author/10003266 Szebeni János true 10003266 true Szebeni János true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 18739325 /api/publicationidentifier/18739325 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fimmu.2021.642860 https://doi.org/10.3389/fimmu.2021.642860 false true PublicationIdentifier 18832089 /api/publicationidentifier/18832089 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000649285000001 https://www.webofscience.com/wos/woscc/full-record/000649285000001 false true PublicationIdentifier 26897034 /api/publicationidentifier/26897034 SwordSource 92 /api/publicationsource/92 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true EDIT EDIT https://edit.elte.hu/xmlui/handle/10831/@@@ true true 92 true GREEN true 110763 https://edit.elte.hu/xmlui/handle/10831/110763 false true PublicationIdentifier 18872894 /api/publicationidentifier/18872894 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85105941183 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85105941183 false true PublicationIdentifier 18872895 /api/publicationidentifier/18872895 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33995361 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33995361&dopt=Abstract false true SjrRating 11219532 /api/sjrrating/11219532 31 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2403 /api/classificationexternal/2403 true 2403 true Q1 DIRECT true true /api/publication/31997628 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10024742"><a href="/gui2/?type=authors&mode=browse&sel=10024742" target="_blank">Kozma Gergely Tibor (<span class="authorship-author-name">Kozma Gergely Tibor</span> <span class="authorAux-mtmt"> Immunológia, Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064003"><a href="/gui2/?type=authors&mode=browse&sel=10064003" target="_blank">Mészáros Tamás (<span class="authorship-author-name">Mészáros Tamás</span> <span class="authorAux-mtmt"> nanomedicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070223"><a href="/gui2/?type=authors&mode=browse&sel=10070223" target="_blank">Bakos Tamás (<span class="authorship-author-name">Bakos Tamás</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hennies Mark </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075321"><a href="/gui2/?type=authors&mode=browse&sel=10075321" target="_blank">Bencze Dániel (<span class="authorship-author-name">Bencze Dániel</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Immunológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035041"><a href="/gui2/?type=authors&mode=browse&sel=10035041" target="_blank">Uzonyi Barbara (<span class="authorship-author-name">Uzonyi Barbara</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/<span title="Immunológiai Tanszék">Imm_Tsz</span>/MTA-ELTE Komplement Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika; <span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Enzimológiai Intézet">EI</span>/Onkológiai Biomarker Kutatócsoport (Lendület)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cedrone Edward </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dobrovolskaia Marina A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019323"><a href="/gui2/?type=authors&mode=browse&sel=10019323" target="_blank">Józsi Mihály (<span class="authorship-author-name">Józsi Mihály</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Immunológiai Tanszék; <span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/<span title="Immunológiai Tanszék">Imm_Tsz</span>/MTA-ELTE Komplement Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003266"><a href="/gui2/?type=authors&mode=browse&sel=10003266" target="_blank">Szebeni János ✉ (<span class="authorship-author-name">Szebeni János</span> <span class="authorAux-mtmt"> Klinikai orvostudomány, immunológia, nanomedicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ; <span title="Miskolci Egyetem">ME</span>/<span title="Egészségtudományi Kar ">ETK</span>/Elméleti Egészségtudományok Intézete</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31997628" target="_blank">Mini-Factor H Modulates Complement-Dependent IL-6 and IL-10 Release in an Immune Cell Culture (PBMC) Model: Potential Benefits Against Cytokine Storm</a></div> <div> <span class="journal-title">FRONTIERS IN IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a>)</span>: <span class="journal-volume">12</span> <span class="page"> Paper 642860. 13 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fimmu.2021.642860" target="_blank" href="https://doi.org/10.3389/fimmu.2021.642860"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000649285000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000649285000001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="110763" target="_blank" href="https://edit.elte.hu/xmlui/handle/10831/110763"> EDIT </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85105941183" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85105941183"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33995361" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33995361&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 16</span> | Független: 10 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 13 | Scopus jelölt:&nbsp;15 | WoS/Scopus jelölt:&nbsp;16 | DOI jelölt:&nbsp;16 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31997628&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31997628</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (825825), European Union Horizon 2020 projects(952520), (2nd Department of Pediatry, Semmelweis University), (0106307) Támogató: MTA, (D11206), (NKFIH-1157/8/2019) </div> <div class="lastModified">Utolsó módosítás: 2026.01.29. 16:09 Szabó Regina (ELTE TTK admin 5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Nanomedicine Research and Education Center, Institute of Translational Medicine, Semmelweis University, Budapest, Hungary SeroScience LCC, Budapest, Hungary TECOdevelopment GmbH, Rheinbach, Germany MTA-ELTE Complement Research Group, Eötvös Loránd Research Network (ELKH), Department of Immunology, ELTE Eötvös Loránd Univers...</pre> </div></div> JournalArticle 30731425 VALIDATED true 0 false 2026-06-01T16:29:01.874+0000 2022-05-11T08:11:23.616+0000 2019-07-05T13:49:32.974+0000 true 10014641 Kökény Gábor /api/author/10014641 Author true 10014641 2022-07-20T11:08:48.753+0000 2020-01-20T08:58:32.125+0000 true 10069606 Pintér Ibolya Katalin /api/admin/10069606 Admin true 2022-05-11T08:11:23.818+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Németh, Ágnes The PPAR gamma agonist pioglitazone prevents TGF-beta induced renal fibrosis by repressing EGR-1 and STAT3 true true /api/journal/10015510 REVIEWED true false 10015510 false 10015510 true 1471-2369 1471-2369 Journal FOREIGN 20 1 245 245 9 2019 BackgroundIt has been proposed that peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists might reduce renal fibrosis, however, several studies had contradictory results. Moreover, the possible interaction of TGF-beta(1), PPAR gamma, and transcription factors in renal fibrosis have not been investigated. We hypothesized that oral pioglitazone treatment would inhibit TGF-beta-driven renal fibrosis and its progression, by modulating profibrotic transcription factors in TGF-beta(1) transgenic mice.MethodsMale C57Bl/6J mice (control, CTL, n=14) and TGF-beta overexpressing transgenic mice (TGF beta, n=14, having elevated plasma TGF-beta(1) level) were divided in two sets at 10weeks of age. Mice in the first set were fed with regular rodent chow (CTL and TGF beta, n=7/group). Mice in the second set were fed with chow containing pioglitazone (at a dose of 20mg/kg/day, CTL+Pio and TGF beta+Pio, n=7/group). After 5weeks of treatment, blood pressure was assessed and urine samples were collected, and the kidneys were analyzed for histology, mRNA and protein expression.ResultsTGF-beta(1) induced glomerulosclerosis and tubulointerstitial damage were significantly reduced by pioglitazone. Pioglitazone inhibited renal mRNA expression of all the profibrotic effectors: type-III collagen, TGF-beta(1), CTGF and TIMP-1, and alike transcription factors cFos/cJun and protein expression of EGR-1, and STAT3 protein phosphorylation.ConclusionsOral administration of PPAR gamma agonist pioglitazone significantly reduces TGF-beta(1)-driven renal fibrosis, via the attenuation of EGR-1, STAT3 and AP-1. This implies that PPAR gamma agonists might be effective in the treatment of chronic kidney disease patients. true true 2019 true true true false true false GOLD 2026-06-01 true https://doi.org/10.1186/s12882-019-1431-x 69 0 69 59 9 69 68 64 61 68 68 58 58 59 10 0 69 59 69 59 0 5 5 Q2 true 10015693,10014641 false false false 2019-10-14T10:18:24.838+0000 Kórélettani Intézet (SE / AOK / I) 3 9 1 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 87511315 /api/authorship/87511315 1 0.2 true false Author 10051754 /api/author/10051754 Németh Ágnes true 10051754 true Németh Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87511316 /api/authorship/87511316 2 0.2 false false Author 10015693 /api/author/10015693 Mózes Miklós true 10015693 true Mózes Miklós M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87511317 /api/authorship/87511317 3 0.2 false false Calvier Laurent true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87511318 /api/authorship/87511318 4 0.2 false false Hansmann Georg true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87511319 /api/authorship/87511319 5 0.2 false true true Author 10014641 /api/author/10014641 Kökény Gábor true 10014641 true Kökény Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 16053616 /api/publicationidentifier/16053616 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1186/s12882-019-1431-x https://doi.org/10.1186/s12882-019-1431-x false true PublicationIdentifier 16053615 /api/publicationidentifier/16053615 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000474559900001 https://www.webofscience.com/wos/woscc/full-record/000474559900001 false true PublicationIdentifier 16517777 /api/publicationidentifier/16517777 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85069269365 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85069269365 false true PublicationIdentifier 15807355 /api/publicationidentifier/15807355 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 31277592 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31277592&dopt=Abstract false true SjrRating 10860690 /api/sjrrating/10860690 22 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2727 /api/classificationexternal/2727 true 2727 true Q2 DIRECT true true /api/publication/30731425 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10051754"><a href="/gui2/?type=authors&mode=browse&sel=10051754" target="_blank">Németh Ágnes (<span class="authorship-author-name">Németh Ágnes</span> <span class="authorAux-mtmt"> Nephrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Kórélettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015693"><a href="/gui2/?type=authors&mode=browse&sel=10015693" target="_blank">Mózes Miklós M. (<span class="authorship-author-name">Mózes Miklós</span> <span class="authorAux-mtmt"> Nephrologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Kórélettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Calvier Laurent </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hansmann Georg </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014641"><a href="/gui2/?type=authors&mode=browse&sel=10014641" target="_blank">Kökény Gábor ✉ (<span class="authorship-author-name">Kökény Gábor</span> <span class="authorAux-mtmt"> Nefrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Kórélettani Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30731425" target="_blank">The PPAR gamma agonist pioglitazone prevents TGF-beta induced renal fibrosis by repressing EGR-1 and STAT3</a></div> <div> <span class="journal-title">BMC NEPHROLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1471-2369">1471-2369</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1471-2369">1471-2369</a>)</span>: <span class="journal-volume">20</span> <span class="journal-issue">1</span> <span class="page"> Paper 245. 9 p. </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/s12882-019-1431-x" target="_blank" href="https://doi.org/10.1186/s12882-019-1431-x"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000474559900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000474559900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85069269365" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85069269365"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31277592" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31277592&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Nephrology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 69</span> | Független: 59 | Függő: 10 | Nem jelölt: 0 | WoS jelölt: 64 | Scopus jelölt:&nbsp;61 | WoS/Scopus jelölt:&nbsp;68 | DOI jelölt:&nbsp;68 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30731425&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30731425</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2022.05.11. 10:11 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> </div></div>