https://m2.mtmt.hu/ hun 2026-06-13 08:45 true true 1 1 1 1 100 1 1 DESC publishedYear false ASC firstAuthor true ASC title true JournalArticle 30731425 VALIDATED true 0 false 2026-06-01T16:29:01.874+0000 2022-05-11T08:11:23.616+0000 2019-07-05T13:49:32.974+0000 true 10014641 Kökény Gábor /api/author/10014641 Author true 10014641 2022-07-20T11:08:48.753+0000 2020-01-20T08:58:32.125+0000 true 10069606 Pintér Ibolya Katalin /api/admin/10069606 Admin true 2022-05-11T08:11:23.818+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Németh, Ágnes The PPAR gamma agonist pioglitazone prevents TGF-beta induced renal fibrosis by repressing EGR-1 and STAT3 true true /api/journal/10015510 REVIEWED true false 10015510 false 10015510 true 1471-2369 1471-2369 Journal FOREIGN 20 1 245 245 9 2019 BackgroundIt has been proposed that peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists might reduce renal fibrosis, however, several studies had contradictory results. Moreover, the possible interaction of TGF-beta(1), PPAR gamma, and transcription factors in renal fibrosis have not been investigated. We hypothesized that oral pioglitazone treatment would inhibit TGF-beta-driven renal fibrosis and its progression, by modulating profibrotic transcription factors in TGF-beta(1) transgenic mice.MethodsMale C57Bl/6J mice (control, CTL, n=14) and TGF-beta overexpressing transgenic mice (TGF beta, n=14, having elevated plasma TGF-beta(1) level) were divided in two sets at 10weeks of age. Mice in the first set were fed with regular rodent chow (CTL and TGF beta, n=7/group). Mice in the second set were fed with chow containing pioglitazone (at a dose of 20mg/kg/day, CTL+Pio and TGF beta+Pio, n=7/group). After 5weeks of treatment, blood pressure was assessed and urine samples were collected, and the kidneys were analyzed for histology, mRNA and protein expression.ResultsTGF-beta(1) induced glomerulosclerosis and tubulointerstitial damage were significantly reduced by pioglitazone. Pioglitazone inhibited renal mRNA expression of all the profibrotic effectors: type-III collagen, TGF-beta(1), CTGF and TIMP-1, and alike transcription factors cFos/cJun and protein expression of EGR-1, and STAT3 protein phosphorylation.ConclusionsOral administration of PPAR gamma agonist pioglitazone significantly reduces TGF-beta(1)-driven renal fibrosis, via the attenuation of EGR-1, STAT3 and AP-1. This implies that PPAR gamma agonists might be effective in the treatment of chronic kidney disease patients. true true 2019 true true true false true false GOLD 2026-06-01 true https://doi.org/10.1186/s12882-019-1431-x 69 0 69 59 9 69 68 64 61 68 68 58 58 59 10 0 69 59 69 59 0 5 5 Q2 true 10015693,10014641 false false false 2019-10-14T10:18:24.838+0000 Kórélettani Intézet (SE / AOK / I) 3 9 1 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 87511315 /api/authorship/87511315 1 0.2 true false Author 10051754 /api/author/10051754 Németh Ágnes true 10051754 true Németh Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87511316 /api/authorship/87511316 2 0.2 false false Author 10015693 /api/author/10015693 Mózes Miklós true 10015693 true Mózes Miklós M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87511317 /api/authorship/87511317 3 0.2 false false Calvier Laurent true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87511318 /api/authorship/87511318 4 0.2 false false Hansmann Georg true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87511319 /api/authorship/87511319 5 0.2 false true true Author 10014641 /api/author/10014641 Kökény Gábor true 10014641 true Kökény Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 16053616 /api/publicationidentifier/16053616 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1186/s12882-019-1431-x https://doi.org/10.1186/s12882-019-1431-x false true PublicationIdentifier 16053615 /api/publicationidentifier/16053615 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000474559900001 https://www.webofscience.com/wos/woscc/full-record/000474559900001 false true PublicationIdentifier 16517777 /api/publicationidentifier/16517777 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85069269365 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85069269365 false true PublicationIdentifier 15807355 /api/publicationidentifier/15807355 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 31277592 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31277592&dopt=Abstract false true SjrRating 10860690 /api/sjrrating/10860690 22 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2727 /api/classificationexternal/2727 true 2727 true Q2 DIRECT true true /api/publication/30731425 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10051754"><a href="/gui2/?type=authors&mode=browse&sel=10051754" target="_blank">Németh Ágnes (<span class="authorship-author-name">Németh Ágnes</span> <span class="authorAux-mtmt"> Nephrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Kórélettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015693"><a href="/gui2/?type=authors&mode=browse&sel=10015693" target="_blank">Mózes Miklós M. (<span class="authorship-author-name">Mózes Miklós</span> <span class="authorAux-mtmt"> Nephrologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Kórélettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Calvier Laurent </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hansmann Georg </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014641"><a href="/gui2/?type=authors&mode=browse&sel=10014641" target="_blank">Kökény Gábor ✉ (<span class="authorship-author-name">Kökény Gábor</span> <span class="authorAux-mtmt"> Nefrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Kórélettani Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30731425" target="_blank">The PPAR gamma agonist pioglitazone prevents TGF-beta induced renal fibrosis by repressing EGR-1 and STAT3</a></div> <div> <span class="journal-title">BMC NEPHROLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1471-2369">1471-2369</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1471-2369">1471-2369</a>)</span>: <span class="journal-volume">20</span> <span class="journal-issue">1</span> <span class="page"> Paper 245. 9 p. </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/s12882-019-1431-x" target="_blank" href="https://doi.org/10.1186/s12882-019-1431-x"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000474559900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000474559900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85069269365" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85069269365"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31277592" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31277592&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Nephrology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 69</span> | Független: 59 | Függő: 10 | Nem jelölt: 0 | WoS jelölt: 64 | Scopus jelölt:&nbsp;61 | WoS/Scopus jelölt:&nbsp;68 | DOI jelölt:&nbsp;68 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30731425&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30731425</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2022.05.11. 10:11 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> </div></div>